JP2017513818A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017513818A5 JP2017513818A5 JP2016557287A JP2016557287A JP2017513818A5 JP 2017513818 A5 JP2017513818 A5 JP 2017513818A5 JP 2016557287 A JP2016557287 A JP 2016557287A JP 2016557287 A JP2016557287 A JP 2016557287A JP 2017513818 A5 JP2017513818 A5 JP 2017513818A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- domain
- antigen
- cancer
- car
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 CS-1 Proteins 0.000 claims 57
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 53
- 239000000427 antigen Substances 0.000 claims 39
- 108091007433 antigens Proteins 0.000 claims 39
- 102000036639 antigens Human genes 0.000 claims 39
- 210000004027 cell Anatomy 0.000 claims 34
- 230000011664 signaling Effects 0.000 claims 28
- 206010028980 Neoplasm Diseases 0.000 claims 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 239000012642 immune effector Substances 0.000 claims 20
- 229940121354 immunomodulator Drugs 0.000 claims 20
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 102100024263 CD160 antigen Human genes 0.000 claims 15
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims 15
- 230000000139 costimulatory effect Effects 0.000 claims 15
- 230000004068 intracellular signaling Effects 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 239000013598 vector Substances 0.000 claims 15
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 14
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 13
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 13
- 102100026094 C-type lectin domain family 12 member A Human genes 0.000 claims 12
- 101710188619 C-type lectin domain family 12 member A Proteins 0.000 claims 12
- 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims 12
- 102100032816 Integrin alpha-6 Human genes 0.000 claims 12
- 102100029197 SLAM family member 6 Human genes 0.000 claims 12
- 102100038083 Endosialin Human genes 0.000 claims 11
- 101000884275 Homo sapiens Endosialin Proteins 0.000 claims 10
- 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 claims 10
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims 10
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 10
- 102100025323 Integrin alpha-1 Human genes 0.000 claims 10
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 10
- 102100025390 Integrin beta-2 Human genes 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 230000004048 modification Effects 0.000 claims 9
- 238000012986 modification Methods 0.000 claims 9
- 102100038078 CD276 antigen Human genes 0.000 claims 8
- 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 claims 8
- 101001035237 Homo sapiens Integrin alpha-D Proteins 0.000 claims 8
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 8
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims 8
- 101001138062 Homo sapiens Leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 claims 8
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 8
- 101000633780 Homo sapiens Signaling lymphocytic activation molecule Proteins 0.000 claims 8
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 8
- 102100039904 Integrin alpha-D Human genes 0.000 claims 8
- 102100022297 Integrin alpha-X Human genes 0.000 claims 8
- 102100025304 Integrin beta-1 Human genes 0.000 claims 8
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims 8
- 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 claims 8
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims 8
- 102100029198 SLAM family member 7 Human genes 0.000 claims 8
- 102100027744 Semaphorin-4D Human genes 0.000 claims 8
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims 8
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 8
- 102000001301 EGF receptor Human genes 0.000 claims 7
- 108060006698 EGF receptor Proteins 0.000 claims 7
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 7
- 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 claims 7
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 7
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 7
- 102000003911 Thyrotropin Receptors Human genes 0.000 claims 7
- 108090000253 Thyrotropin Receptors Proteins 0.000 claims 7
- 230000003834 intracellular effect Effects 0.000 claims 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 6
- 101710109924 A-kinase anchor protein 4 Proteins 0.000 claims 6
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 6
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 6
- 102100026402 Adhesion G protein-coupled receptor E2 Human genes 0.000 claims 6
- 108010051118 Bone Marrow Stromal Antigen 2 Proteins 0.000 claims 6
- 102100037086 Bone marrow stromal antigen 2 Human genes 0.000 claims 6
- 108700012439 CA9 Proteins 0.000 claims 6
- 102100027207 CD27 antigen Human genes 0.000 claims 6
- 102100029390 CMRF35-like molecule 1 Human genes 0.000 claims 6
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 6
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 6
- 102000012466 Cytochrome P450 1B1 Human genes 0.000 claims 6
- 108050002014 Cytochrome P450 1B1 Proteins 0.000 claims 6
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims 6
- 101710116743 Ephrin type-A receptor 2 Proteins 0.000 claims 6
- 108010007712 Hepatitis A Virus Cellular Receptor 1 Proteins 0.000 claims 6
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims 6
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 6
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims 6
- 101000990055 Homo sapiens CMRF35-like molecule 1 Proteins 0.000 claims 6
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 6
- 101001046687 Homo sapiens Integrin alpha-E Proteins 0.000 claims 6
- 101001136981 Homo sapiens Proteasome subunit beta type-9 Proteins 0.000 claims 6
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 6
- 101000894428 Homo sapiens Transcriptional repressor CTCFL Proteins 0.000 claims 6
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 6
- 101001047681 Homo sapiens Tyrosine-protein kinase Lck Proteins 0.000 claims 6
- 101000814512 Homo sapiens X antigen family member 1 Proteins 0.000 claims 6
- 102100029616 Immunoglobulin lambda-like polypeptide 1 Human genes 0.000 claims 6
- 101710107067 Immunoglobulin lambda-like polypeptide 1 Proteins 0.000 claims 6
- 102100022341 Integrin alpha-E Human genes 0.000 claims 6
- 102100022338 Integrin alpha-M Human genes 0.000 claims 6
- 102100025586 Leukocyte immunoglobulin-like receptor subfamily A member 2 Human genes 0.000 claims 6
- 101710196509 Leukocyte immunoglobulin-like receptor subfamily A member 2 Proteins 0.000 claims 6
- 102100021852 Neuronal cell adhesion molecule Human genes 0.000 claims 6
- 101710130688 Neuronal cell adhesion molecule Proteins 0.000 claims 6
- 102100025128 Olfactory receptor 51E2 Human genes 0.000 claims 6
- 101710187841 Olfactory receptor 51E2 Proteins 0.000 claims 6
- 102100032364 Pannexin-3 Human genes 0.000 claims 6
- 101710165197 Pannexin-3 Proteins 0.000 claims 6
- 102100026181 Placenta-specific protein 1 Human genes 0.000 claims 6
- 108050005093 Placenta-specific protein 1 Proteins 0.000 claims 6
- 101710164680 Platelet-derived growth factor receptor beta Proteins 0.000 claims 6
- 101710120463 Prostate stem cell antigen Proteins 0.000 claims 6
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 6
- 102100035764 Proteasome subunit beta type-9 Human genes 0.000 claims 6
- 101710149284 Protein SSX2 Proteins 0.000 claims 6
- 102100037686 Protein SSX2 Human genes 0.000 claims 6
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 6
- 102100027610 Rho-related GTP-binding protein RhoC Human genes 0.000 claims 6
- 206010039491 Sarcoma Diseases 0.000 claims 6
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 6
- 102100021393 Transcriptional repressor CTCFL Human genes 0.000 claims 6
- 102100031989 Transmembrane protease serine 2 Human genes 0.000 claims 6
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 6
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 6
- 102100024036 Tyrosine-protein kinase Lck Human genes 0.000 claims 6
- 102000013532 Uroplakin II Human genes 0.000 claims 6
- 108010065940 Uroplakin II Proteins 0.000 claims 6
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 6
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 6
- 102100039490 X antigen family member 1 Human genes 0.000 claims 6
- 108010003374 fms-Like Tyrosine Kinase 3 Proteins 0.000 claims 6
- 108010073531 rhoC GTP-Binding Protein Proteins 0.000 claims 6
- 108010088201 squamous cell carcinoma-related antigen Proteins 0.000 claims 6
- 230000005945 translocation Effects 0.000 claims 6
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 5
- 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 claims 5
- 102100032187 Androgen receptor Human genes 0.000 claims 5
- 102100023003 Ankyrin repeat domain-containing protein 30A Human genes 0.000 claims 5
- 102100025218 B-cell differentiation antigen CD72 Human genes 0.000 claims 5
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 5
- 108010058905 CD44v6 antigen Proteins 0.000 claims 5
- 101100518995 Caenorhabditis elegans pax-3 gene Proteins 0.000 claims 5
- 102100038449 Claudin-6 Human genes 0.000 claims 5
- 108010060385 Cyclin B1 Proteins 0.000 claims 5
- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 5
- 102000010449 Folate receptor beta Human genes 0.000 claims 5
- 108050001930 Folate receptor beta Proteins 0.000 claims 5
- 102000003817 Fos-related antigen 1 Human genes 0.000 claims 5
- 108090000123 Fos-related antigen 1 Proteins 0.000 claims 5
- 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 claims 5
- 102000010956 Glypican Human genes 0.000 claims 5
- 108050001154 Glypican Proteins 0.000 claims 5
- 108050007237 Glypican-3 Proteins 0.000 claims 5
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 5
- 101000718211 Homo sapiens Adhesion G protein-coupled receptor E2 Proteins 0.000 claims 5
- 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 claims 5
- 101000757191 Homo sapiens Ankyrin repeat domain-containing protein 30A Proteins 0.000 claims 5
- 101000934359 Homo sapiens B-cell differentiation antigen CD72 Proteins 0.000 claims 5
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 5
- 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 claims 5
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 5
- 101000971605 Homo sapiens Kita-kyushu lung cancer antigen 1 Proteins 0.000 claims 5
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 5
- 101001051490 Homo sapiens Neural cell adhesion molecule L1 Proteins 0.000 claims 5
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 5
- 101000824971 Homo sapiens Sperm surface protein Sp17 Proteins 0.000 claims 5
- 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 claims 5
- 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 claims 5
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 5
- 102100021533 Kita-kyushu lung cancer antigen 1 Human genes 0.000 claims 5
- 102100032129 Lymphocyte antigen 6K Human genes 0.000 claims 5
- 102100033486 Lymphocyte antigen 75 Human genes 0.000 claims 5
- 101710157884 Lymphocyte antigen 75 Proteins 0.000 claims 5
- 102100034256 Mucin-1 Human genes 0.000 claims 5
- 101100518997 Mus musculus Pax3 gene Proteins 0.000 claims 5
- 101100351020 Mus musculus Pax5 gene Proteins 0.000 claims 5
- 101100481410 Mus musculus Tek gene Proteins 0.000 claims 5
- 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims 5
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 5
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 5
- 102100022748 Wilms tumor protein Human genes 0.000 claims 5
- 101710127857 Wilms tumor protein Proteins 0.000 claims 5
- 101100351021 Xenopus laevis pax5 gene Proteins 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 108010080146 androgen receptors Proteins 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000002446 fucosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)[C@@H](O1)C)* 0.000 claims 5
- 230000004927 fusion Effects 0.000 claims 5
- PFJKOHUKELZMLE-VEUXDRLPSA-N ganglioside GM3 Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(=O)CCCCCCCCCCCCC\C=C/CCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 PFJKOHUKELZMLE-VEUXDRLPSA-N 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 201000001441 melanoma Diseases 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 108010056102 CD100 antigen Proteins 0.000 claims 4
- 102100038077 CD226 antigen Human genes 0.000 claims 4
- 101150013553 CD40 gene Proteins 0.000 claims 4
- 108010062802 CD66 antigens Proteins 0.000 claims 4
- 102100027217 CD82 antigen Human genes 0.000 claims 4
- 101710139831 CD82 antigen Proteins 0.000 claims 4
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims 4
- 102100035167 Coiled-coil domain-containing protein 54 Human genes 0.000 claims 4
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 claims 4
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims 4
- 101000882898 Homo sapiens Claudin-6 Proteins 0.000 claims 4
- 101000737052 Homo sapiens Coiled-coil domain-containing protein 54 Proteins 0.000 claims 4
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 claims 4
- 101001046683 Homo sapiens Integrin alpha-L Proteins 0.000 claims 4
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 4
- 101001046668 Homo sapiens Integrin alpha-X Proteins 0.000 claims 4
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 claims 4
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 4
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims 4
- 101000873418 Homo sapiens P-selectin glycoprotein ligand 1 Proteins 0.000 claims 4
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims 4
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 4
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 4
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 4
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 4
- 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 claims 4
- 102100022339 Integrin alpha-L Human genes 0.000 claims 4
- 108010041100 Integrin alpha6 Proteins 0.000 claims 4
- 108010030465 Integrin alpha6beta1 Proteins 0.000 claims 4
- 102100033016 Integrin beta-7 Human genes 0.000 claims 4
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 4
- 101100236305 Mus musculus Ly9 gene Proteins 0.000 claims 4
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 4
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 4
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims 4
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 4
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims 4
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims 4
- 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims 4
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 claims 4
- 102000014128 RANK Ligand Human genes 0.000 claims 4
- 108010025832 RANK Ligand Proteins 0.000 claims 4
- 102100029216 SLAM family member 5 Human genes 0.000 claims 4
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 4
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 4
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 4
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 4
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 4
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 4
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 4
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 4
- 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 claims 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 4
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 4
- 230000000735 allogeneic effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 210000000822 natural killer cell Anatomy 0.000 claims 4
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 3
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 3
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 3
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 3
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 3
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 3
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 3
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 3
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims 3
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 3
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 102000017578 LAG3 Human genes 0.000 claims 3
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 102000010292 Peptide Elongation Factor 1 Human genes 0.000 claims 3
- 108010077524 Peptide Elongation Factor 1 Proteins 0.000 claims 3
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 3
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 3
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 3
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 3
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 3
- 210000002865 immune cell Anatomy 0.000 claims 3
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 108010017009 CD11b Antigen Proteins 0.000 claims 2
- 101710185679 CD276 antigen Proteins 0.000 claims 2
- 102100035793 CD83 antigen Human genes 0.000 claims 2
- 102100037904 CD9 antigen Human genes 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 101100534087 Cowpox virus (strain Brighton Red) CRMA gene Proteins 0.000 claims 2
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims 2
- 208000017815 Dendritic cell tumor Diseases 0.000 claims 2
- 102000011107 Diacylglycerol Kinase Human genes 0.000 claims 2
- 108010062677 Diacylglycerol Kinase Proteins 0.000 claims 2
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 2
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 2
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 2
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 claims 2
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 2
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 2
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 2
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 2
- 101000608769 Homo sapiens Galectin-8 Proteins 0.000 claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 2
- 101000824104 Homo sapiens High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 claims 2
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 2
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 2
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 claims 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 2
- 101000980827 Homo sapiens T-cell surface glycoprotein CD1a Proteins 0.000 claims 2
- 101000716149 Homo sapiens T-cell surface glycoprotein CD1b Proteins 0.000 claims 2
- 101000716124 Homo sapiens T-cell surface glycoprotein CD1c Proteins 0.000 claims 2
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 2
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 2
- 102000004553 Interleukin-11 Receptors Human genes 0.000 claims 2
- 108010017521 Interleukin-11 Receptors Proteins 0.000 claims 2
- 101150030213 Lag3 gene Proteins 0.000 claims 2
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 2
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 2
- 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 claims 2
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 2
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 2
- 102000003735 Mesothelin Human genes 0.000 claims 2
- 108090000015 Mesothelin Proteins 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 102000011755 Phosphoglycerate Kinase Human genes 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 229940116193 Protein phosphatase inhibitor Drugs 0.000 claims 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 2
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 2
- 102100024219 T-cell surface glycoprotein CD1a Human genes 0.000 claims 2
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 2
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims 2
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000001506 immunosuppresive effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 229940043355 kinase inhibitor Drugs 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229940124302 mTOR inhibitor Drugs 0.000 claims 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000003934 phosphoprotein phosphatase inhibitor Substances 0.000 claims 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 210000003289 regulatory T cell Anatomy 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 1
- LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 claims 1
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 1
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 101710096292 Adhesion G protein-coupled receptor E2 Proteins 0.000 claims 1
- 108060003345 Adrenergic Receptor Proteins 0.000 claims 1
- 102000017910 Adrenergic receptor Human genes 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 102000009840 Angiopoietins Human genes 0.000 claims 1
- 108010009906 Angiopoietins Proteins 0.000 claims 1
- 101710145634 Antigen 1 Proteins 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 claims 1
- 102000030431 Asparaginyl endopeptidase Human genes 0.000 claims 1
- 241000271566 Aves Species 0.000 claims 1
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 208000032568 B-cell prolymphocytic leukaemia Diseases 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 108091007065 BIRCs Proteins 0.000 claims 1
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 206010006143 Brain stem glioma Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 claims 1
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 1
- 108010051152 Carboxylesterase Proteins 0.000 claims 1
- 102000013392 Carboxylesterase Human genes 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 1
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 206010007953 Central nervous system lymphoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 108090000229 Claudin-6 Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 229940083347 Cyclin-dependent kinase 4 inhibitor Drugs 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000012804 EPCAM Human genes 0.000 claims 1
- 101150084967 EPCAM gene Proteins 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 102100031780 Endonuclease Human genes 0.000 claims 1
- 108010042407 Endonucleases Proteins 0.000 claims 1
- 101710144543 Endosialin Proteins 0.000 claims 1
- 102100023721 Ephrin-B2 Human genes 0.000 claims 1
- 108010044090 Ephrin-B2 Proteins 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 206010061850 Extranodal marginal zone B-cell lymphoma (MALT type) Diseases 0.000 claims 1
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 1
- 102000010451 Folate receptor alpha Human genes 0.000 claims 1
- 108050001931 Folate receptor alpha Proteins 0.000 claims 1
- 108091006027 G proteins Proteins 0.000 claims 1
- 102000027583 GPCRs class C Human genes 0.000 claims 1
- 108091008882 GPCRs class C Proteins 0.000 claims 1
- 102000030782 GTP binding Human genes 0.000 claims 1
- 108091000058 GTP-Binding Proteins 0.000 claims 1
- 102000044445 Galectin-8 Human genes 0.000 claims 1
- 102100039554 Galectin-8 Human genes 0.000 claims 1
- 101710088083 Glomulin Proteins 0.000 claims 1
- 102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 1
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101000954709 Homo sapiens Doublecortin domain-containing protein 2 Proteins 0.000 claims 1
- 101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101000985516 Homo sapiens Hermansky-Pudlak syndrome 5 protein Proteins 0.000 claims 1
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 1
- 101000614481 Homo sapiens Kidney-associated antigen 1 Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 claims 1
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 1
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 1
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims 1
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101001094545 Homo sapiens Retrotransposon-like protein 1 Proteins 0.000 claims 1
- 101000665137 Homo sapiens Scm-like with four MBT domains protein 1 Proteins 0.000 claims 1
- 208000019758 Hypergammaglobulinemia Diseases 0.000 claims 1
- 101150102264 IE gene Proteins 0.000 claims 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 1
- 102000017182 Ikaros Transcription Factor Human genes 0.000 claims 1
- 108010013958 Ikaros Transcription Factor Proteins 0.000 claims 1
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 1
- 102000055031 Inhibitor of Apoptosis Proteins Human genes 0.000 claims 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 1
- 108010017511 Interleukin-13 Receptors Proteins 0.000 claims 1
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 1
- 102100039078 Interleukin-4 receptor subunit alpha Human genes 0.000 claims 1
- 102100034872 Kallikrein-4 Human genes 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102100031413 L-dopachrome tautomerase Human genes 0.000 claims 1
- 101710093778 L-dopachrome tautomerase Proteins 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 201000003791 MALT lymphoma Diseases 0.000 claims 1
- 102100031520 MAPK/MAK/MRK overlapping kinase Human genes 0.000 claims 1
- 108010010995 MART-1 Antigen Proteins 0.000 claims 1
- 102000016200 MART-1 Antigen Human genes 0.000 claims 1
- 208000032271 Malignant tumor of penis Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 1
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 101710151472 Neuroendocrine convertase 1 Proteins 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- KUIFHYPNNRVEKZ-VIJRYAKMSA-N O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine Chemical compound OC(=O)[C@@H](N)[C@@H](C)O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O KUIFHYPNNRVEKZ-VIJRYAKMSA-N 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 108700020796 Oncogene Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 102100040891 Paired box protein Pax-3 Human genes 0.000 claims 1
- 101710149060 Paired box protein Pax-3 Proteins 0.000 claims 1
- 102100037504 Paired box protein Pax-5 Human genes 0.000 claims 1
- 101710149067 Paired box protein Pax-5 Proteins 0.000 claims 1
- 108091081548 Palindromic sequence Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000000821 Parathyroid Neoplasms Diseases 0.000 claims 1
- 208000002471 Penile Neoplasms Diseases 0.000 claims 1
- 206010034299 Penile cancer Diseases 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 201000005746 Pituitary adenoma Diseases 0.000 claims 1
- 206010061538 Pituitary tumour benign Diseases 0.000 claims 1
- 102100037891 Plexin domain-containing protein 1 Human genes 0.000 claims 1
- 108050009432 Plexin domain-containing protein 1 Proteins 0.000 claims 1
- 108091036407 Polyadenylation Proteins 0.000 claims 1
- 102100037935 Polyubiquitin-C Human genes 0.000 claims 1
- 208000006994 Precancerous Conditions Diseases 0.000 claims 1
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 1
- 208000007541 Preleukemia Diseases 0.000 claims 1
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 1
- 208000035416 Prolymphocytic B-Cell Leukemia Diseases 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100026034 Protein BTG2 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 101710173694 Short transient receptor potential channel 2 Proteins 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 102100022441 Sperm surface protein Sp17 Human genes 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 101800001271 Surface protein Proteins 0.000 claims 1
- 108010002687 Survivin Proteins 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 101150057140 TACSTD1 gene Proteins 0.000 claims 1
- 108010017842 Telomerase Proteins 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 101710081844 Transmembrane protease serine 2 Proteins 0.000 claims 1
- 102100039094 Tyrosinase Human genes 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 claims 1
- 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 claims 1
- 102100021657 Tyrosine-protein phosphatase non-receptor type 6 Human genes 0.000 claims 1
- 101710128901 Tyrosine-protein phosphatase non-receptor type 6 Proteins 0.000 claims 1
- 108010056354 Ubiquitin C Proteins 0.000 claims 1
- 208000023915 Ureteral Neoplasms Diseases 0.000 claims 1
- 206010046392 Ureteric cancer Diseases 0.000 claims 1
- 206010046431 Urethral cancer Diseases 0.000 claims 1
- 206010046458 Urethral neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 101710101493 Viral myc transforming protein Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 230000005809 anti-tumor immunity Effects 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 238000002617 apheresis Methods 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 108010055066 asparaginylendopeptidase Proteins 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 150000002270 gangliosides Chemical class 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000003259 immunoinhibitory effect Effects 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 108010024383 kallikrein 4 Proteins 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 230000001589 lymphoproliferative effect Effects 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000029559 malignant endocrine neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000020984 malignant renal pelvis neoplasm Diseases 0.000 claims 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims 1
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 1
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 238000012737 microarray-based gene expression Methods 0.000 claims 1
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 101710135378 pH 6 antigen Proteins 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000021310 pituitary gland adenoma Diseases 0.000 claims 1
- 208000007525 plasmablastic lymphoma Diseases 0.000 claims 1
- 210000005134 plasmacytoid dendritic cell Anatomy 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 108040000983 polyphosphate:AMP phosphotransferase activity proteins Proteins 0.000 claims 1
- 208000016800 primary central nervous system lymphoma Diseases 0.000 claims 1
- 108010013873 proacrosin Proteins 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 201000007444 renal pelvis carcinoma Diseases 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 125000005630 sialyl group Chemical group 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000002314 small intestine cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 101150047061 tag-72 gene Proteins 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
- 230000005747 tumor angiogenesis Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046885 vaginal cancer Diseases 0.000 claims 1
- 208000013139 vaginal neoplasm Diseases 0.000 claims 1
- 201000005102 vulva cancer Diseases 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461953783P | 2014-03-15 | 2014-03-15 | |
| US61/953,783 | 2014-03-15 | ||
| US201461976375P | 2014-04-07 | 2014-04-07 | |
| US61/976,375 | 2014-04-07 | ||
| US201462027154P | 2014-07-21 | 2014-07-21 | |
| US62/027,154 | 2014-07-21 | ||
| US201462076146P | 2014-11-06 | 2014-11-06 | |
| US62/076,146 | 2014-11-06 | ||
| US201462097286P | 2014-12-29 | 2014-12-29 | |
| US62/097,286 | 2014-12-29 | ||
| PCT/US2015/020606 WO2015142675A2 (en) | 2014-03-15 | 2015-03-13 | Treatment of cancer using chimeric antigen receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019126002A Division JP6860623B2 (ja) | 2014-03-15 | 2019-07-05 | キメラ抗原受容体を使用する癌の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017513818A JP2017513818A (ja) | 2017-06-01 |
| JP2017513818A5 true JP2017513818A5 (enExample) | 2018-04-19 |
Family
ID=52780057
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016557287A Pending JP2017513818A (ja) | 2014-03-15 | 2015-03-13 | キメラ抗原受容体を使用する癌の処置 |
| JP2019126002A Active JP6860623B2 (ja) | 2014-03-15 | 2019-07-05 | キメラ抗原受容体を使用する癌の処置 |
| JP2021053240A Active JP7526121B2 (ja) | 2014-03-15 | 2021-03-26 | キメラ抗原受容体を使用する癌の処置 |
| JP2024115421A Pending JP2024164002A (ja) | 2014-03-15 | 2024-07-19 | キメラ抗原受容体を使用する癌の処置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019126002A Active JP6860623B2 (ja) | 2014-03-15 | 2019-07-05 | キメラ抗原受容体を使用する癌の処置 |
| JP2021053240A Active JP7526121B2 (ja) | 2014-03-15 | 2021-03-26 | キメラ抗原受容体を使用する癌の処置 |
| JP2024115421A Pending JP2024164002A (ja) | 2014-03-15 | 2024-07-19 | キメラ抗原受容体を使用する癌の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20170335281A1 (enExample) |
| EP (2) | EP3593812A3 (enExample) |
| JP (4) | JP2017513818A (enExample) |
| CN (1) | CN106163547A (enExample) |
| ES (1) | ES2939760T3 (enExample) |
| WO (1) | WO2015142675A2 (enExample) |
Families Citing this family (502)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2683352T3 (es) | 2009-04-13 | 2018-09-26 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Partículas de HPV y usos de las mismas |
| ES2949648T3 (es) | 2012-12-20 | 2023-10-02 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| US9573988B2 (en) | 2013-02-20 | 2017-02-21 | Novartis Ag | Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells |
| MX374929B (es) | 2013-02-20 | 2025-03-06 | Novartis Ag | RECEPTOR QUIMERICO DE ANTIGENO anti-EGFRvlll HUMANIZADO Y USOS DEL MISMO. |
| WO2014145252A2 (en) | 2013-03-15 | 2014-09-18 | Milone Michael C | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| KR102452767B1 (ko) | 2013-05-14 | 2022-10-12 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 가공된 키메라 항원 수용체 (ｃａｒ) ｔ-세포의 인간 적용 |
| ES2917573T3 (es) | 2013-09-18 | 2022-07-08 | Aura Biosciences Inc | Método de producción de moléculas fotosensibles |
| US10640569B2 (en) | 2013-12-19 | 2020-05-05 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
| EP3087101B1 (en) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| EP4303229A3 (en) | 2014-01-21 | 2024-04-17 | Novartis AG | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| EP3105335B1 (en) | 2014-02-14 | 2019-10-02 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors and methods of making |
| ES2939760T3 (es) | 2014-03-15 | 2023-04-26 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico para antígenos |
| HUE054588T2 (hu) | 2014-04-07 | 2021-09-28 | Novartis Ag | Rák kezelése CD19 elleni, kiméra antigénreceptor alkalmazásával |
| JP6788573B6 (ja) | 2014-04-10 | 2020-12-16 | シアトル チルドレンズ ホスピタル， ディービーエー シアトル チルドレンズ リサーチ インスティテュート | メトトレキサートによる選択と組み合わせたＳｌｅｅｐｉｎｇ Ｂｅａｕｔｙトランスポゾンによる遺伝子改変Ｔ細胞の製造 |
| US11041021B2 (en) | 2014-05-23 | 2021-06-22 | University Of Florida Research Foundation, Incorporated | Car based immunotherapy |
| GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| KR102612313B1 (ko) | 2014-07-21 | 2023-12-12 | 노파르티스 아게 | 인간화 항-bcma 키메라 항원 수용체를 사용한 암의 치료 |
| WO2016014530A1 (en) * | 2014-07-21 | 2016-01-28 | Novartis Ag | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| CN107109420A (zh) | 2014-07-21 | 2017-08-29 | 诺华股份有限公司 | 使用cll－1嵌合抗原受体的癌症治疗 |
| US9777061B2 (en) | 2014-07-21 | 2017-10-03 | Novartis Ag | Treatment of cancer using a CD33 chimeric antigen receptor |
| JP6588084B2 (ja) * | 2014-08-19 | 2019-10-09 | ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｓｅａ４抗原に特異的なキメラ抗原受容体 |
| PL3183268T3 (pl) | 2014-08-19 | 2020-09-07 | Novartis Ag | Chimeryczny receptor antygenowy (CAR) anty-CD123 do zastosowania w leczeniu nowotworu złośliwego |
| WO2016044605A1 (en) | 2014-09-17 | 2016-03-24 | Beatty, Gregory | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| WO2016057705A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
| CN107206025A (zh) | 2014-12-03 | 2017-09-26 | 朱诺治疗学股份有限公司 | 用于过继细胞治疗的方法和组合物 |
| US20180334490A1 (en) | 2014-12-03 | 2018-11-22 | Qilong H. Wu | Methods for b cell preconditioning in car therapy |
| ES2899779T3 (es) | 2014-12-05 | 2022-03-14 | Memorial Sloan Kettering Cancer Center | Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos |
| JP6753851B2 (ja) | 2014-12-05 | 2020-09-09 | メモリアル スローン ケタリング キャンサー センター | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| CN113603795A (zh) | 2014-12-05 | 2021-11-05 | 纪念斯隆-凯特琳癌症中心 | 靶向b-细胞成熟抗原的嵌合抗原受体及其用途 |
| SMT202100221T1 (it) | 2014-12-05 | 2021-07-12 | Memorial Sloan Kettering Cancer Center | Anticorpi bersaglianti l'antigene di maturazione delle cellule e metodi d'uso |
| CN109072199B (zh) | 2014-12-05 | 2022-10-28 | 纪念斯隆-凯特琳癌症中心 | 靶向Fc受体样5的嵌合抗原受体及其用途 |
| US20190054117A1 (en) * | 2014-12-19 | 2019-02-21 | Novartis Ag | Dimerization switches and uses thereof |
| CA2972597A1 (en) | 2014-12-29 | 2016-07-07 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
| JP2018504145A (ja) | 2015-01-26 | 2018-02-15 | セレクティスＣｅｌｌｅｃｔｉｓ | 再発性／難治性急性骨髄性リンパ腫または芽球性形質細胞様樹状細胞新生物を処置するための、ｃｄ１２３に結合するキメラ抗原受容体を賦与された、操作されたｔ細胞受容体ノックアウト免疫細胞 |
| US11161907B2 (en) * | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| US10647778B2 (en) | 2015-02-09 | 2020-05-12 | University Of Florida Research Foundation, Incorporated | Bi-specific chimeric antigen receptor and uses thereof |
| WO2016134284A1 (en) | 2015-02-19 | 2016-08-25 | University Of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
| EP3258967A4 (en) | 2015-02-20 | 2018-10-03 | Ohio State Innovation Foundation | Bivalent antibody directed against nkg2d and tumor associated antigens |
| JP6336684B2 (ja) | 2015-03-02 | 2018-06-06 | イノベイティブ セルラー セラピューティクス シーオー．，エルティディ．Ｉｎｎｏｖａｔｉｖｅ Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏ．，Ｌｔｄ． | Ｐｄ−ｌ１によって誘導される免疫寛容の低減 |
| EP3270936A4 (en) | 2015-03-17 | 2018-08-08 | Chimera Bioengineering Inc. | Smart car devices, de car polypeptides, side cars and uses thereof |
| CN106146666B (zh) * | 2015-03-26 | 2019-09-06 | 科济生物医药（上海）有限公司 | 靶向cldn6的免疫效应细胞及其制备方法和应用 |
| HK1250918A1 (zh) | 2015-04-06 | 2019-01-18 | Cytoimmune Therapeutics, Inc. | 用於胶质母细胞瘤的egfr导向的car疗法 |
| CN119925616A (zh) | 2015-04-08 | 2025-05-06 | 诺华股份有限公司 | Cd20疗法、cd22疗法和与cd19嵌合抗原受体（car）表达细胞的联合疗法 |
| ES2948133T3 (es) | 2015-04-17 | 2023-08-31 | Novartis Ag | Métodos para mejorar la eficacia y expansión de células que expresan un receptor de antígeno quimérico |
| US12128069B2 (en) | 2015-04-23 | 2024-10-29 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| JP2018515123A (ja) | 2015-05-18 | 2018-06-14 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 |
| WO2016187594A1 (en) | 2015-05-21 | 2016-11-24 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| TWI859112B (zh) | 2015-07-21 | 2024-10-21 | 瑞士商諾華公司 | 改良免疫細胞之功效及擴展之方法 |
| ES2939084T3 (es) * | 2015-07-29 | 2023-04-18 | Onk Therapeutics Ltd | Células asesinas naturales y líneas de células asesinas naturales modificadas que tienen citotoxicidad aumentada |
| IL257105B (en) | 2015-07-31 | 2022-09-01 | Univ Minnesota | Modified cells and methods of therapy |
| WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
| CA2994829A1 (en) | 2015-08-07 | 2017-02-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Bispecific car t-cells for solid tumor targeting |
| CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| GB201514874D0 (en) * | 2015-08-20 | 2015-10-07 | Autolus Ltd | Cell |
| WO2017040324A1 (en) * | 2015-08-28 | 2017-03-09 | The Trustees Of The University Of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
| JP6905163B2 (ja) | 2015-09-03 | 2021-07-21 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | サイトカイン放出症候群を予測するバイオマーカー |
| EP3344806A4 (en) | 2015-09-04 | 2019-03-20 | OBI Pharma, Inc. | GLYCANARRAYS AND METHOD OF USE |
| EP3569244A1 (en) | 2015-09-23 | 2019-11-20 | CytoImmune Therapeutics, LLC | Flt3 directed car cells for immunotherapy |
| CN105567649A (zh) * | 2015-10-26 | 2016-05-11 | 哈尔滨新联合生物科技有限公司 | 一种修饰的增强型dc-cik靶向免疫细胞群的制备方法和用途 |
| EP3368075B1 (en) * | 2015-10-27 | 2020-01-29 | Board of Regents, The University of Texas System | Chimeric antigen receptor molecules and uses thereof |
| WO2017075451A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1 |
| WO2017075465A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3 |
| WO2017075537A1 (en) * | 2015-10-30 | 2017-05-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
| KR20180083868A (ko) | 2015-10-30 | 2018-07-23 | 알레타 바이오쎄라퓨틱스, 인크. | 종양 형질도입용 조성물 및 방법 |
| US11207339B2 (en) | 2015-10-30 | 2021-12-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Targeted cancer therapy |
| SG11201803098VA (en) | 2015-10-30 | 2018-05-30 | Nbe Therapeutics Ag | Anti-ror1 antibodies |
| TW202216787A (zh) * | 2015-11-18 | 2022-05-01 | 美商默沙東藥廠 | Pd1及／或 lag3結合劑 |
| EP3377076A4 (en) * | 2015-11-19 | 2019-07-31 | Bloodcenter Research Foundation | METHOD FOR PRODUCING DOUBLE-SPECIFIC T CELLS FOR USE IN CANCER IMMUNOTHERAPY |
| MA43380A (fr) | 2015-12-03 | 2018-10-10 | Juno Therapeutics Inc | Récepteurs chimériques modifiés et compositions et procédés associés |
| PH12018501177B1 (en) | 2015-12-04 | 2024-01-24 | Eureka Therapeutics Inc | Antibodies targeting fc receptor-like 5 and methods of use |
| CA3006432A1 (en) | 2015-12-04 | 2017-06-08 | Novartis Ag | Compositions and methods for immunooncology |
| US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| CN109069597A (zh) | 2015-12-22 | 2018-12-21 | 诺华股份有限公司 | 间皮素嵌合抗原受体(car)和抗pd-l1抗体抑制剂联用于抗癌治疗 |
| EP3397755B1 (en) | 2015-12-28 | 2024-11-06 | Novartis AG | Methods of making chimeric antigen receptor -expressing cells |
| MX2018008106A (es) | 2015-12-30 | 2019-03-14 | Novartis Ag | Terapias con celulas inmunoefectoras de una eficacia mejorada. |
| US11236174B2 (en) | 2016-01-12 | 2022-02-01 | Crescendo Biologics Limited | Therapeutic molecules |
| JP7000660B2 (ja) | 2016-01-20 | 2022-02-04 | ザ スクリプス リサーチ インスティテュート | Ｒｏｒ１抗体組成物及び関連の方法 |
| JOP20170017B1 (ar) | 2016-01-25 | 2021-08-17 | Amgen Res Munich Gmbh | تركيب صيدلي يتضمن تركيبات جسم مضاد ثنائي الاختصاص |
| AU2017224843A1 (en) * | 2016-02-25 | 2018-08-23 | Cell Medica Switzerland Ag | Binding members to PD-L1 |
| EP3423482A1 (en) | 2016-03-04 | 2019-01-09 | Novartis AG | Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore |
| TW202248213A (zh) * | 2016-03-15 | 2022-12-16 | 日商中外製藥股份有限公司 | 使用pd-1軸結合拮抗劑和抗gpc3抗體治療癌症的方法 |
| US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| WO2017165683A1 (en) | 2016-03-23 | 2017-09-28 | Novartis Ag | Cell secreted minibodies and uses thereof |
| EP4286522A3 (en) * | 2016-03-23 | 2024-02-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
| BR112018070097A2 (pt) | 2016-03-29 | 2019-02-12 | Obi Pharma, Inc. | anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| JP7208010B2 (ja) | 2016-03-29 | 2023-01-18 | ユニバーシティ オブ サザン カリフォルニア | 癌を標的とするキメラ抗原受容体 |
| TWI787599B (zh) | 2016-04-01 | 2022-12-21 | 美商凱特製藥公司 | 嵌合抗原和ｔ細胞受體及使用方法 |
| CN113082201B (zh) * | 2016-04-01 | 2024-07-05 | 上海斯丹赛生物技术有限公司 | 刺激t细胞介导的对表达抗原的细胞群的免疫应答的方法 |
| ES2930058T3 (es) * | 2016-04-01 | 2022-12-05 | Kite Pharma Inc | Receptores quiméricos y métodos de uso de los mismos |
| US10654934B2 (en) | 2016-04-01 | 2020-05-19 | Innovative Cellular Therapeutics CO., LTD. | Use of chimeric antigen receptor modified cells to treat cancer |
| SG10201912515XA (en) | 2016-04-01 | 2020-02-27 | Kite Pharma Inc | Bcma binding molecules and methods of use thereof |
| MY210545A (en) * | 2016-04-01 | 2025-09-30 | Kite Pharma Inc | Chimeric receptors to flt3 and methods of use thereof |
| EP3440191A4 (en) * | 2016-04-07 | 2019-12-11 | Bluebird Bio, Inc. | CHIMERIC ANTIGEN RECEPTOR T-CELL COMPOSITIONS |
| WO2017177149A2 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| EP3439685B1 (en) * | 2016-04-08 | 2023-07-05 | Emory University | Methods of treating cancer and infectious diseases using cell based therapies |
| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| US20190125840A1 (en) * | 2016-04-12 | 2019-05-02 | Philogen S.P.A. | Combination therapy comprising an inflammatory immunocytokine and a chimeric antigen receptor (car)-t cell |
| CN106399255B (zh) * | 2016-04-13 | 2019-10-18 | 阿思科力(苏州)生物科技有限公司 | Pd-1 car-t细胞及其制备方法和应用 |
| PL3443096T3 (pl) | 2016-04-15 | 2023-06-19 | Novartis Ag | Kompozycje i sposoby do selektywnej ekspresji chimerycznych receptorów antygenowych |
| CN105907719B (zh) * | 2016-04-18 | 2019-10-18 | 阿思科力(苏州)生物科技有限公司 | Anti ROBO1 CAR-T细胞及其制备和应用 |
| CA3021548A1 (en) | 2016-04-22 | 2017-10-26 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via globo series antigens |
| US11634498B2 (en) | 2016-04-29 | 2023-04-25 | University Of Florida Research Foundation, Incorporated | Chimeric antigen receptors and uses thereof |
| GB201607968D0 (en) * | 2016-05-06 | 2016-06-22 | Crescendo Biolog Ltd | Chimeric antigen receptor |
| EP3458077A4 (en) | 2016-05-17 | 2020-04-01 | Chimera Bioengineering Inc. | METHODS OF MANUFACTURING NEW AREAS OF ANTIGEN BINDING |
| JP7101621B2 (ja) | 2016-05-20 | 2022-07-15 | ハープーン セラピューティクス，インク． | 単一ドメイン血清アルブミン結合タンパク質 |
| KR101926166B1 (ko) * | 2016-05-24 | 2018-12-06 | 재단법인 아산사회복지재단 | 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법 |
| KR102366813B1 (ko) | 2016-05-27 | 2022-02-24 | 아게누스 인코포레이티드 | 항-tim-3 항체 및 이의 사용 방법 |
| US11299546B2 (en) | 2016-05-27 | 2022-04-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | FLT3-specific chimeric antigen receptors and methods using same |
| EP3464375A2 (en) | 2016-06-02 | 2019-04-10 | Novartis AG | Therapeutic regimens for chimeric antigen receptor (car)- expressing cells |
| IL321834A (en) | 2016-06-08 | 2025-08-01 | Precigen Inc | Cd33 specific chimeric antigen receptors |
| EP3468581A1 (en) | 2016-06-13 | 2019-04-17 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| CN115381832A (zh) | 2016-07-14 | 2022-11-25 | 深圳明赛瑞霖药业有限公司 | 癌症的治疗 |
| WO2018012895A1 (ko) * | 2016-07-14 | 2018-01-18 | 주식회사 큐로셀 | 면역관문을 극복한 면역세포 및 상기 면역세포를 포함한 약제학적 조성물 |
| AU2017295886C1 (en) | 2016-07-15 | 2024-05-16 | Novartis Ag | Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor |
| CN106220736B (zh) * | 2016-07-20 | 2020-01-10 | 深圳市体内生物医药科技有限公司 | 一种嵌合抗原受体、表达其的细胞及其制备方法和用途 |
| KR20190038567A (ko) * | 2016-07-26 | 2019-04-08 | 테사 테라퓨틱스 피티이. 엘티디. | 키메라 항원 수용체 |
| AU2017302038B2 (en) | 2016-07-27 | 2024-03-21 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| TW202508628A (zh) | 2016-07-28 | 2025-03-01 | 瑞士商諾華公司 | 嵌合抗原受體及pd-1抑制劑之組合療法 |
| KR102528998B1 (ko) | 2016-07-29 | 2023-05-03 | 오비아이 파머 인코퍼레이티드 | 인간 항체, 제약 조성물 및 방법 |
| RU2019105693A (ru) | 2016-08-01 | 2020-09-01 | Новартис Аг | Лечение рака с применением химерного антигенного рецептора в комбинации с ингибитором молекулы, способствующей фенотипу m2 макрофага |
| EP3494138A1 (en) | 2016-08-02 | 2019-06-12 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CA3032838A1 (en) * | 2016-08-04 | 2018-02-08 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| WO2018027197A1 (en) * | 2016-08-04 | 2018-02-08 | Memorial Sloan-Kettering Cancer Center | Cancer antigen targets and uses thereof |
| RU2767206C2 (ru) * | 2016-08-12 | 2022-03-16 | Тулджен Инкорпорейтед | Модифицированный иммунорегуляторный элемент и изменение иммунитета посредством этого элемента |
| AU2017313828B2 (en) * | 2016-08-18 | 2019-12-05 | IN8bio, Inc. | Compositions and methods for cancer immunotherapy |
| WO2018045034A1 (en) * | 2016-08-30 | 2018-03-08 | Promab Biotechnologies, Inc. | Chimeric antigen receptors having gitr intracellular domain as co-stimulatory domain |
| CN112481217A (zh) | 2016-09-01 | 2021-03-12 | 嵌合体生物工程公司 | Gold优化的car t-细胞 |
| CN107793482A (zh) * | 2016-09-06 | 2018-03-13 | 广州百尼夫生物科技有限公司 | 嵌合抗原受体及其基因和重组表达载体、car133‑nkt 细胞及其制备方法和应用 |
| US20190262399A1 (en) | 2016-09-07 | 2019-08-29 | The Broad Institute, Inc. | Compositions and methods for evaluating and modulating immune responses |
| US20200056174A1 (en) * | 2016-09-08 | 2020-02-20 | Dana-Farber Cancer Institute, Inc. | Compositions and methods of treating cancer |
| CN106434563B (zh) * | 2016-09-14 | 2017-09-22 | 深圳市默赛尔生物医学科技发展有限公司 | 转基因自然杀伤细胞及其制备方法和应用 |
| WO2018053542A1 (en) | 2016-09-19 | 2018-03-22 | University Of Southern California | Non-radioactive cytotoxicity assays |
| WO2018057915A1 (en) | 2016-09-23 | 2018-03-29 | The Regents Of The University Of Michigan | Engineered lymphocytes |
| CN107868791B (zh) * | 2016-09-26 | 2021-11-23 | 阿思科力(苏州)生物科技有限公司 | 一种加强型Slit2 CAR-T和CAR-NK细胞制备方法和应用 |
| CN106317228A (zh) * | 2016-09-28 | 2017-01-11 | 李华顺 | 一种嵌合抗原受体分子及其应用 |
| CN109844126A (zh) | 2016-09-28 | 2019-06-04 | 诺华股份有限公司 | 基于多孔膜的大分子递送系统 |
| US20190233797A1 (en) * | 2016-09-29 | 2019-08-01 | Nantkwest, Inc. | Hla class i-deficient nk-92 cells with decreased immunogenicity |
| CA3154236C (en) * | 2016-09-30 | 2023-08-29 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
| US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
| WO2018064921A1 (en) * | 2016-10-06 | 2018-04-12 | Innovative Cellular Therapeutics CO., LTD. | Use of chimeric antigen receptor modified cells to treat cancer |
| IL292551B2 (en) | 2016-10-07 | 2023-10-01 | Tcr2 Therapeutics Inc | Preparations and methods for reprogramming T-cell receptors using fusion proteins |
| EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
| EP3522936A4 (en) * | 2016-10-10 | 2020-06-24 | The National Institute for Biotechnology in the Negev, Ltd. | Non-cytotoxic modified cells and use thereof |
| NZ792355A (en) | 2016-10-11 | 2025-12-19 | Agenus Inc | Anti-lag-3 antibodies and methods of use thereof |
| SG11201903282TA (en) | 2016-10-13 | 2019-05-30 | Juno Therapeutics Inc | Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators |
| CN110520530A (zh) | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
| EP3529353A4 (en) | 2016-10-19 | 2020-05-13 | City of Hope | USE OF TRIPLEX-CMV VACCINE IN CAR-T-CELL THERAPY |
| CN107988164B (zh) * | 2016-10-26 | 2020-07-07 | 阿思科力(苏州)生物科技有限公司 | 一种pd-1 car nk-92细胞及其制备方法与应用 |
| CN106591363A (zh) * | 2016-11-11 | 2017-04-26 | 广东万海细胞生物科技有限公司 | 一种通用型异体car‑t细胞制备方法及应用 |
| US11332713B2 (en) | 2016-11-16 | 2022-05-17 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| AU2017363311A1 (en) | 2016-11-22 | 2019-06-13 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| CN110352068A (zh) | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
| MX2019006285A (es) * | 2016-12-03 | 2019-12-16 | Juno Therapeutics Inc | Metodos para modulacion de celulas cart-t. |
| JP2020511462A (ja) * | 2016-12-03 | 2020-04-16 | ジュノー セラピューティクス インコーポレイテッド | キナーゼ阻害剤との組み合わせで治療用ｔ細胞を使用するための方法および組成物 |
| CN106701827A (zh) * | 2016-12-05 | 2017-05-24 | 刘晓明 | 表达cd19和cd20抗体基因嵌合抗原受体t细胞的转化及扩增培养与保存方法 |
| EP3548030A4 (en) | 2016-12-05 | 2020-08-12 | G1 Therapeutics, Inc. | PRESERVATION OF THE IMMUNE RESPONSE DURING CHEMOTHERAPEUTIC DIETS |
| EP4104841A1 (en) | 2016-12-09 | 2022-12-21 | ONK Therapeutics Limited | Engineered natural killer cells and uses thereof |
| AU2017375630B2 (en) | 2016-12-12 | 2023-12-21 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
| WO2018111340A1 (en) | 2016-12-16 | 2018-06-21 | Novartis Ag | Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells |
| CN108204958A (zh) * | 2016-12-19 | 2018-06-26 | 伊缪泰普有限公司 | 结合测定 |
| US20210187022A1 (en) * | 2016-12-21 | 2021-06-24 | TCR2 Therapeutics Inc. | Engineered t cells for the treatment of cancer |
| US20190352363A1 (en) | 2016-12-22 | 2019-11-21 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| CA3047508A1 (en) * | 2016-12-23 | 2018-06-28 | Virttu Biologics Limited | Treatment of cancer |
| CN110121505B (zh) | 2016-12-28 | 2023-08-01 | 株式会社绿十字细胞治疗 | 嵌合抗原受体和表达其的自然杀伤细胞 |
| CN107286246B (zh) * | 2016-12-28 | 2019-12-17 | 时力生物科技（北京）有限公司 | 治疗脑胶质瘤的嵌合抗原受体修饰的树突状细胞及其制备方法 |
| CN108276493B (zh) * | 2016-12-30 | 2023-11-14 | 南京传奇生物科技有限公司 | 一种嵌合抗原受体及其应用 |
| US11591398B2 (en) | 2017-01-06 | 2023-02-28 | Crescendo Biologics Limited | Single domain antibodies to programmed cell death protein 1 (PD-1) |
| AU2018207281B2 (en) | 2017-01-10 | 2024-08-01 | Precigen, Inc. | Modulating expression of polypeptides via new gene switch expression systems |
| CN110494451B (zh) * | 2017-01-13 | 2023-12-01 | 塞尔达拉医疗有限责任公司 | 靶向tim-1的嵌合抗原受体 |
| EP3572428A4 (en) | 2017-01-17 | 2020-12-30 | Daiichi Sankyo Company, Limited | ANTI-BODY ANTI-GPR20 AND ANTI-BODY-DRUG CONJUGATE ANTI-GPR20 |
| EP3570850A4 (en) * | 2017-01-18 | 2020-10-14 | Thalia Papayannopoulou | PACKAGING COMPOSITIONS AND METHODS FOR A TRANSPLANT RECEIVER |
| CN108330133B (zh) * | 2017-01-20 | 2020-06-30 | 上海恒润达生生物科技有限公司 | 靶向cd19嵌合抗原受体并对其双重修饰的方法及其用途 |
| EP3574005B1 (en) | 2017-01-26 | 2021-12-15 | Novartis AG | Cd28 compositions and methods for chimeric antigen receptor therapy |
| US20190375815A1 (en) * | 2017-01-31 | 2019-12-12 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| CN108395478A (zh) * | 2017-02-04 | 2018-08-14 | 上海恒润达生生物科技有限公司 | 靶向bcma的嵌合抗原受体并对其双重修饰的方法及其用途 |
| TW201837174A (zh) * | 2017-02-07 | 2018-10-16 | 日商第一三共股份有限公司 | 抗ｇｐｒｃ５ｄ抗體及包含該抗體之分子 |
| CN108456250B (zh) * | 2017-02-17 | 2025-11-28 | 恺兴生命科技(上海)有限公司 | 靶向il-13ra2的抗体及其应用 |
| CA3052779A1 (en) | 2017-02-17 | 2018-08-23 | Fred Hutchinson Cancer Research Center | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| EP3568469A4 (en) * | 2017-02-21 | 2020-11-11 | Eutilex Co., Ltd. | COMPOSITIONS OF CAR-T CELLS DIRECTED AGAINST HLA-DR AND THEIR MANUFACTURING AND USE PROCEDURES |
| IL311608A (en) * | 2017-03-13 | 2024-05-01 | Poseida Therapeutics Inc | Preparations and methods for the selective elimination and replacement of hematopoietic stem cells |
| WO2018169922A2 (en) | 2017-03-13 | 2018-09-20 | Kite Pharma, Inc. | Chimeric antigen receptors for melanoma and uses thereof |
| JP7061134B2 (ja) * | 2017-03-20 | 2022-04-27 | ユニバーシティ オブ サザン カリフォルニア | 薬剤負荷ナノ粒子が表面に結合したｃａｒ ｔ細胞の養子移入およびその使用 |
| SG11201907434RA (en) | 2017-03-22 | 2019-10-30 | Novartis Ag | Compositions and methods for immunooncology |
| CN107271675B (zh) * | 2017-03-24 | 2020-06-02 | 郑猛 | 抗人adrb3单克隆抗体及其在疾病诊断和治疗中的应用 |
| BR112019020168A2 (pt) | 2017-03-27 | 2020-06-02 | F. Hoffmann-La Roche Ag | Receptores de ligação ao antígeno, células t transduzidas, polinucleotídeo isolado, vetor, kits, métodos para tratar uma doença e para induzir a lise de uma célula alvo e uso do receptor de ligação ao antígeno |
| US11963966B2 (en) | 2017-03-31 | 2024-04-23 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating ovarian tumors |
| WO2018183921A1 (en) | 2017-04-01 | 2018-10-04 | The Broad Institute, Inc. | Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer |
| US20200071773A1 (en) | 2017-04-12 | 2020-03-05 | Massachusetts Eye And Ear Infirmary | Tumor signature for metastasis, compositions of matter methods of use thereof |
| JP2020517259A (ja) | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
| MX420947B (es) | 2017-04-26 | 2025-02-10 | Eureka Therapeutics Inc | Constructos que reconocen específicamente glipicano 3 y usos de estos. |
| CN109790518A (zh) * | 2017-05-08 | 2019-05-21 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| JP7235391B2 (ja) | 2017-05-08 | 2023-03-08 | ツールゲン インコーポレイテッド | 人工的に操作された免疫細胞 |
| WO2018209324A2 (en) | 2017-05-11 | 2018-11-15 | The Broad Institute, Inc. | Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof |
| AU2018367896B2 (en) | 2017-05-12 | 2023-06-01 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| CN111406068A (zh) | 2017-05-16 | 2020-07-10 | 约翰霍普金斯大学 | MANAbody及使用方法 |
| CN108853144A (zh) * | 2017-05-16 | 2018-11-23 | 科济生物医药（上海）有限公司 | Toll样受体激动剂与免疫效应细胞的联用 |
| CN110709424B (zh) * | 2017-05-31 | 2024-01-05 | 科济生物医药（上海）有限公司 | 细胞免疫治疗的组合物和方法 |
| CN110770348B (zh) * | 2017-06-01 | 2023-12-15 | 浙江煦顼技术有限公司 | 嵌合抗原受体细胞的制备及其用途 |
| EP3630837A1 (en) | 2017-06-02 | 2020-04-08 | Pfizer Inc | Chimeric antigen receptors targeting flt3 |
| CN108977453A (zh) | 2017-06-02 | 2018-12-11 | 阿思科力(苏州)生物科技有限公司 | 一种以robo1为靶点的嵌合抗原受体细胞及其制备和应用 |
| EP3635099A4 (en) * | 2017-06-07 | 2021-02-24 | The General Hospital Corporation | T-CELLS WITH EXPRESSION OF A CHIMERIC ANTIGEN RECEPTOR |
| CN110944652A (zh) * | 2017-06-12 | 2020-03-31 | 爱莫里大学 | T细胞抗原靶向的嵌合抗原受体(car)以及在细胞疗法中的用途 |
| EP3638218A4 (en) | 2017-06-14 | 2021-06-09 | The Broad Institute, Inc. | COMPOSITIONS AND METHOD OF TARGETING COMPLEMENTING COMPONENT 3 FOR INHIBITION OF TUMOR GROWTH |
| CN109134660B (zh) * | 2017-06-16 | 2022-07-01 | 上海恒润达生生物科技股份有限公司 | 靶向Mesothelin的嵌合抗原受体并联合表达抗PD1抗体的方法及其用途 |
| KR20200019231A (ko) * | 2017-06-22 | 2020-02-21 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 조절 면역 세포를 제조하기 위한 방법 및 이의 용도 |
| CN107164412B (zh) * | 2017-06-30 | 2020-10-23 | 山东兴瑞生物科技有限公司 | 一种安全型抗cea嵌合抗原受体修饰t细胞的制备方法及其应用 |
| AU2018292181B2 (en) | 2017-06-30 | 2025-04-10 | Cellectis | Cellular immunotherapy for repetitive administration |
| JP2020530307A (ja) | 2017-06-30 | 2020-10-22 | インティマ・バイオサイエンス，インコーポレーテッド | 遺伝子治療のためのアデノ随伴ウイルスベクター |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| CN109232742B (zh) * | 2017-07-11 | 2021-10-22 | 深圳市第二人民医院 | 一种嵌合抗原受体及其应用 |
| WO2019014581A1 (en) | 2017-07-14 | 2019-01-17 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF A CYTOTOXIC LYMPHOCYTE |
| CN107353325B (zh) * | 2017-07-26 | 2020-08-11 | 中国药科大学 | 叶酸受体α特异性结合肽1及其应用 |
| CN107326014B (zh) * | 2017-07-31 | 2019-09-24 | 时力生物科技（北京）有限公司 | 一种双特异性嵌合抗原受体修饰的t淋巴细胞及其制备方法和应用 |
| CA3071212C (en) | 2017-08-07 | 2023-12-12 | Nbe-Therapeutics Ag | Anthracycline-based antibody drug conjugates having high in vivo tolerability |
| WO2019036855A1 (en) * | 2017-08-21 | 2019-02-28 | Adagene Inc. | Anti-cd137 molecules and use thereof |
| KR102422860B1 (ko) | 2017-08-31 | 2022-07-19 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트의 신규 제조 방법 |
| US11945882B2 (en) | 2017-08-31 | 2024-04-02 | Daiichi Sankyo Company, Limited | Method for producing antibody-drug conjugate |
| US11524033B2 (en) | 2017-09-05 | 2022-12-13 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| WO2019051135A1 (en) * | 2017-09-06 | 2019-03-14 | Fred Hutchinson Cancer Research Center | METHODS FOR IMPROVING ADOPTIVE CELL THERAPY |
| CN114533863A (zh) * | 2017-09-15 | 2022-05-27 | 凯德药业股份有限公司 | 用于进行具有监管链和身份链生物样品跟踪的患者特异性免疫疗法规程的方法和系统 |
| US12065498B2 (en) | 2017-09-29 | 2024-08-20 | Cell Design Labs, Inc. | Methods of making bispecific anti-CD307E and anti-BCMA chimeric antigen receptors and uses of the same |
| CN107557341B (zh) * | 2017-09-30 | 2020-06-30 | 山东兴瑞生物科技有限公司 | 一种抗wt1增强型嵌合抗原受体修饰的免疫细胞及其应用 |
| EP3695408B1 (en) | 2017-10-02 | 2026-01-21 | The Broad Institute, Inc. | Medical use of cdk4/6- and checkpoint-inhibitors in phased combination, in treatment of cancer |
| US12467050B2 (en) * | 2017-10-02 | 2025-11-11 | Georgia Tech Research Corporation | Methods and compositions for engineering synthetic bioswitches for remote control of biological activity |
| CA3078472A1 (en) * | 2017-10-06 | 2019-04-11 | Oslo Universitetssykehus Hf | Chimeric antigen receptors |
| WO2019071358A1 (en) * | 2017-10-12 | 2019-04-18 | Mcmaster University | Y182T MUTATION T CELL ANTIGEN COUPLEUR AND METHODS AND USES THEREOF |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| PE20201183A1 (es) | 2017-10-13 | 2020-11-03 | Harpoon Therapeutics Inc | Proteinas trispecificas y metodos de uso |
| SG11202003415XA (en) | 2017-10-18 | 2020-05-28 | Novartis Ag | Compositions and methods for selective protein degradation |
| WO2019079777A1 (en) * | 2017-10-20 | 2019-04-25 | Fred Hutchinson Cancer Research Center | COMPOSITIONS AND METHODS FOR TIGIT AND / OR CD112R TARGETING IMMUNOTHERAPY OR COMPRISING THE OVEREXPRESSION OF CD226 |
| KR20200069358A (ko) | 2017-10-25 | 2020-06-16 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
| US11066475B2 (en) | 2017-11-01 | 2021-07-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides |
| AU2018358067A1 (en) | 2017-11-01 | 2020-05-07 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for B-cell maturation antigen |
| CN111886012A (zh) | 2017-11-06 | 2020-11-03 | 朱诺治疗学股份有限公司 | 细胞疗法与γ分泌酶抑制剂的组合 |
| US12171783B2 (en) | 2017-11-13 | 2024-12-24 | The Broad Institute, Inc. | Methods and compositions for targeting developmental and oncogenic programs in H3K27M gliomas |
| WO2019092451A1 (en) | 2017-11-13 | 2019-05-16 | Crescendo Biologics Limited | Single Domain Antibodies that Bind to CD137 |
| EP3710039A4 (en) | 2017-11-13 | 2021-08-04 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH |
| EP3712178A4 (en) | 2017-11-14 | 2021-08-11 | Green Cross Lab Cell Corporation | ANTI-HER2 ANTIBODIES OR ANTIGIBODY FRAGMENT THEREOF AND CHIMERAIR ANTIGEN RECEPTOR WITH IT |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| WO2019099707A1 (en) | 2017-11-16 | 2019-05-23 | Kite Pharma, Inc | Modified chimeric antigen receptors and methods of use |
| CN107916269B (zh) * | 2017-11-17 | 2020-12-11 | 山东兴瑞生物科技有限公司 | 靶向cd19的tcr基因、制备方法、具有该基因的质粒、试剂盒及应用 |
| CN111601824B (zh) * | 2017-11-21 | 2025-10-28 | 诺华股份有限公司 | 针对肿瘤相关抗原的三特异性结合分子及其用途 |
| WO2019111250A1 (en) * | 2017-12-05 | 2019-06-13 | The Medical Research Infrastructure And Health Services Fund Of The Tel Aviv Medical Center | T-cells comprising two different chimeric antigen receptors and uses thereof |
| CN111587254B (zh) | 2017-12-05 | 2025-02-25 | 特拉维夫医疗中心医学研究基础设施及卫生服务基金 | 包含抗cd38和抗cd138嵌合抗原受体的t-细胞及其用途 |
| SG11202005307RA (en) * | 2017-12-14 | 2020-07-29 | Bluebird Bio Inc | Nkg2d daric receptors |
| AU2018393110B2 (en) | 2017-12-20 | 2023-04-27 | Poseida Therapeutics, Inc. | VCAR compositions and methods for use |
| KR20250048610A (ko) | 2017-12-22 | 2025-04-09 | 페이트 세러퓨틱스, 인코포레이티드 | 향상된 면역 효과기 세포 및 이의 용도 |
| CN109609533B (zh) * | 2017-12-27 | 2020-07-10 | 赛德特生物科技开发有限公司 | 基于人源化cd276抗体的car慢病毒表达载体构建及其应用 |
| CN111655271B (zh) * | 2017-12-28 | 2025-09-23 | 隆萨销售股份公司 | 用于免疫肿瘤学和抗炎疗法的外来体 |
| CA3086669A1 (en) * | 2017-12-28 | 2019-07-04 | NEUGATE PHARMA, LLC aka NEUGATE THERANOSTICS | Compositions and formulations for treatment of malignancies |
| CN109971715A (zh) * | 2017-12-28 | 2019-07-05 | 深圳华大生命科学研究院 | 一种扩增特异性car-t细胞的培养方法 |
| CN109971722B (zh) * | 2017-12-28 | 2023-09-01 | 上海细胞治疗研究院 | 靶向cd19且高水平稳定表达cd40抗体的car-t细胞及其用途 |
| CN109971712B (zh) * | 2017-12-28 | 2023-06-20 | 上海细胞治疗研究院 | 特异性靶向cd19抗原且高水平稳定表达pd-1抗体的car-t细胞及用途 |
| CN108103105A (zh) * | 2017-12-29 | 2018-06-01 | 深圳市茵冠生物科技有限公司 | 一种car-t细胞的制备方法、制得的car-t细胞及其应用 |
| CN111867619A (zh) | 2018-01-03 | 2020-10-30 | 曲生物制品公司 | 过继性细胞治疗的先天寻靶 |
| US11994512B2 (en) | 2018-01-04 | 2024-05-28 | Massachusetts Institute Of Technology | Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity |
| EP3508855A1 (en) * | 2018-01-05 | 2019-07-10 | Allianz Pharmascience Ltd | Method for the selection of patients and kit |
| EP3737408A1 (en) * | 2018-01-08 | 2020-11-18 | Novartis AG | Immune-enhancing rnas for combination with chimeric antigen receptor therapy |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| MX2020007338A (es) * | 2018-01-09 | 2020-11-06 | H Lee Moffitt Cancer Ct & Res | Composiciones y métodos para el direccionamiento a tipos de cáncer que expresan clec12a. |
| US10561686B2 (en) * | 2018-01-12 | 2020-02-18 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| EP3737765B2 (en) * | 2018-01-12 | 2025-01-22 | Curocell Inc. | Enhanced immune cells using dual shrna and composition including the same |
| WO2019143818A1 (en) * | 2018-01-17 | 2019-07-25 | Mingsight Pharmaceuticals, Inc. | Combination therapy for the treatment of cancer |
| EP3740569B1 (en) * | 2018-01-19 | 2023-07-26 | Miltenyi Biotec B.V. & Co. KG | Regulatory t cell expressing a chimeric antigen receptor |
| TW201940182A (zh) | 2018-01-22 | 2019-10-16 | 美商安德賽特公司 | Car t 細胞之使用方法 |
| CN110093351B (zh) * | 2018-01-29 | 2023-06-23 | 华南生物医药研究院 | 可分离的核酸、多肽、重组载体、重组细胞及应用 |
| EP3746116A1 (en) * | 2018-01-31 | 2020-12-09 | Novartis AG | Combination therapy using a chimeric antigen receptor |
| CN111989108B (zh) | 2018-02-13 | 2024-07-16 | 嵌合体生物工程公司 | 利用rna去稳定元件协调基因表达 |
| US20210040449A1 (en) | 2018-02-16 | 2021-02-11 | Kite Pharma, Inc. | Modified pluripotent stem cells and methods of making and use |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| US12473336B2 (en) | 2018-02-21 | 2025-11-18 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses thereof |
| JP7568224B2 (ja) * | 2018-02-23 | 2024-10-16 | エンドサイト・インコーポレイテッド | Ｃａｒ ｔ細胞療法のための配列決定法 |
| US10780120B2 (en) * | 2018-03-06 | 2020-09-22 | The Trustees Of The University Of Pennsylvania | Prostate-specific membrane antigen cars and methods of use thereof |
| CN119770648A (zh) * | 2018-03-09 | 2025-04-08 | 克莱格医学有限公司 | 用于治疗肿瘤的方法和组合物 |
| WO2019175328A1 (en) | 2018-03-14 | 2019-09-19 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Bh4pathwayactivationandusethereoffortreatingcancer |
| JP2021518160A (ja) | 2018-03-15 | 2021-08-02 | ケーエスキュー セラピューティクス， インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| EP3765094A4 (en) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | GENE REGULATORY COMPOSITIONS AND PROCEDURES FOR IMPROVED IMMUNOTHERAPY |
| WO2019183389A1 (en) | 2018-03-23 | 2019-09-26 | Kite Pharma, Inc. | Chimeric transmembrane proteins and uses thereof |
| US10688182B2 (en) * | 2018-03-29 | 2020-06-23 | Cho Pharma Usa, Inc. | Monoclonal antibodies that bind to SSEA4 and uses thereof |
| WO2019192972A1 (en) * | 2018-04-04 | 2019-10-10 | F. Hoffmann-La Roche Ag | Diagnostic assays to detect tumor antigens in cancer patients |
| US20190328781A1 (en) * | 2018-04-06 | 2019-10-31 | Mustang Bio, Inc. | Manufacturing methods for cell-based therapeutic compositions |
| US12215337B2 (en) | 2018-04-12 | 2025-02-04 | Umoja Biopharma, Inc. | Viral vectors and packaging cell lines |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
| KR20210005923A (ko) * | 2018-04-27 | 2021-01-15 | 크리스퍼 테라퓨틱스 아게 | 세포독성 t 세포 고갈의 방법 및 조성물 |
| WO2019210293A1 (en) * | 2018-04-27 | 2019-10-31 | Baylor College Of Medicine | Car t cells with one or more interleukins |
| US12201659B2 (en) | 2018-04-27 | 2025-01-21 | Mayo Foundation For Medical Education And Research | Foamy viruses and methods of use |
| WO2019213282A1 (en) | 2018-05-01 | 2019-11-07 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| CN110438082B (zh) * | 2018-05-04 | 2024-03-08 | 恺兴生命科技(上海)有限公司 | 表达il-21r结合蛋白的免疫效应细胞 |
| MX2020012028A (es) | 2018-05-11 | 2021-03-29 | Crispr Therapeutics Ag | Metodos y composiciones para tratar el cancer. |
| AU2019269118B2 (en) | 2018-05-15 | 2025-02-27 | Autolus Limited | Chimeric antigen receptor |
| GB201807870D0 (en) | 2018-05-15 | 2018-06-27 | Autolus Ltd | A CD79-specific chimeric antigen receptor |
| MY203469A (en) * | 2018-05-16 | 2024-06-28 | Stichting Vumc | Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy |
| WO2019227003A1 (en) | 2018-05-25 | 2019-11-28 | Novartis Ag | Combination therapy with chimeric antigen receptor (car) therapies |
| CN108623683B (zh) * | 2018-05-30 | 2021-06-04 | 福州迈新生物技术开发有限公司 | 抗Pax-5蛋白的单克隆抗体及其细胞株、制备方法和应用 |
| CN108715859B (zh) * | 2018-05-31 | 2021-08-03 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 靶向cd22的嵌合抗原受体及其应用 |
| WO2019232519A1 (en) * | 2018-06-01 | 2019-12-05 | Obi Pharma, Inc. | Combination therapy by using anti-globo h or anti-ssea-4 antibody with anti-negative immune check points antibody |
| WO2019232542A2 (en) | 2018-06-01 | 2019-12-05 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients |
| CN110577604A (zh) * | 2018-06-07 | 2019-12-17 | 亘喜生物科技（上海）有限公司 | 携带gitr共刺激信号靶向egfr的嵌合抗原受体t细胞 |
| EP3802825A1 (en) | 2018-06-08 | 2021-04-14 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
| CA3100724A1 (en) | 2018-06-13 | 2019-12-19 | Novartis Ag | B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof |
| US12036240B2 (en) | 2018-06-14 | 2024-07-16 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
| WO2019246563A1 (en) | 2018-06-22 | 2019-12-26 | Kite Pharma, Inc. | Chimeric transmembrane proteins and uses thereof |
| CN112292140B (zh) * | 2018-06-22 | 2025-03-11 | 综合医院公司 | 靶向cd37和cd19的嵌合抗原受体 |
| CN110623980A (zh) * | 2018-06-25 | 2019-12-31 | 深圳宾德生物技术有限公司 | 靶向cd38的嵌合抗原受体t细胞在自身免疫性疾病中的应用 |
| CN108866004A (zh) * | 2018-06-26 | 2018-11-23 | 奥妙生物技术（广州）有限公司 | Shp-1敲除的t细胞及其构建方法 |
| CN108913709A (zh) * | 2018-06-26 | 2018-11-30 | 山东兴瑞生物科技有限公司 | 用于治疗hcc的核酸、其制备方法、具有该核酸的car-t细胞及细胞的制备方法 |
| US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| CN112739717B (zh) * | 2018-06-29 | 2025-02-11 | 璟尚生物制药公司 | 三特异性拮抗剂 |
| WO2020000465A1 (zh) * | 2018-06-29 | 2020-01-02 | 深圳市博奥康生物科技有限公司 | 一种制备lightr基因敲除小鼠的方法 |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| CR20210073A (es) * | 2018-07-04 | 2021-05-12 | Cytoimmune Therapeutics Inc | Composiciones y métodos para inmunoterapia dirigida a flt3, pd-1 y / o pd-l1 |
| WO2020016661A2 (en) * | 2018-07-09 | 2020-01-23 | Multitude Inc. | Antibodies specific to folate receptor alpha |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| US11952419B2 (en) * | 2018-07-10 | 2024-04-09 | University Of Connecticut | Reagents and methods for treating cancer and autoimmune disease |
| US10640562B2 (en) | 2018-07-17 | 2020-05-05 | Mcmaster University | T cell-antigen coupler with various construct optimizations |
| WO2020022475A1 (ja) | 2018-07-27 | 2020-01-30 | 第一三共株式会社 | 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質 |
| KR102894505B1 (ko) | 2018-07-31 | 2025-12-02 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트 투여에 의한 전이성 뇌종양의 치료 |
| JP7623935B2 (ja) * | 2018-08-07 | 2025-01-29 | パーデュー・リサーチ・ファウンデーション | Ｃａｒ ｔ細胞の若返り |
| EP3833742A2 (en) | 2018-08-09 | 2021-06-16 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| CN112888481A (zh) * | 2018-08-10 | 2021-06-01 | 桑格摩生物治疗法国公司 | 包含tnfr2结构域的新型car构建体 |
| CN112384231A (zh) * | 2018-08-26 | 2021-02-19 | 奥伊斯细胞生物技术公司 | 用于治疗胶质母细胞瘤的方法 |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| EP3844265A2 (en) | 2018-08-31 | 2021-07-07 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| TW202538050A (zh) | 2018-08-31 | 2025-10-01 | 瑞士商諾華公司 | 製備表現嵌合抗原受體的細胞之方法 |
| US20200080056A1 (en) * | 2018-09-06 | 2020-03-12 | The Trustees Of The University Of Pennsylvania | CRISPR-Cas9 Knock-out of SHP-1/2 to Reduce T cell Exhaustion in Adoptive Cell Therapy |
| US12529041B2 (en) | 2018-09-07 | 2026-01-20 | Beam Therapeutics Inc. | Compositions and methods for delivering a nucleobase editing system |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| CN109265561B (zh) * | 2018-09-25 | 2021-05-25 | 山东兴瑞生物科技有限公司 | 抗EGFRvⅢ安全型嵌合抗原受体、其制备方法、利用其修饰的NK细胞及应用 |
| CA3114038A1 (en) | 2018-09-25 | 2020-04-02 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| EP3856782A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
| WO2020069405A1 (en) | 2018-09-28 | 2020-04-02 | Novartis Ag | Cd22 chimeric antigen receptor (car) therapies |
| US20210382068A1 (en) | 2018-10-02 | 2021-12-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
| MX2021004058A (es) * | 2018-10-10 | 2021-06-04 | Zymeworks Inc | Construcciones de anticuerpos que se unen a 4-1bb y a antigenos asociados a tumores y sus usos. |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020081730A2 (en) | 2018-10-16 | 2020-04-23 | Massachusetts Institute Of Technology | Methods and compositions for modulating microenvironment |
| EP3640329A1 (en) * | 2018-10-18 | 2020-04-22 | Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Gene editing based cancer treatment |
| CA3114707A1 (en) * | 2018-10-19 | 2020-04-23 | Regents Of The University Of Minnesota | Nk engager molecules and methods of use thereof |
| EP3867279A4 (en) * | 2018-10-19 | 2022-07-13 | Memorial Sloan Kettering Cancer Center | AN AGAINST SIALYL-LEWIS A CHIMERIC ANTIGEN RECEPTOR AND ITS USES |
| WO2020086989A1 (en) * | 2018-10-25 | 2020-04-30 | Innovative Cellular Therapeutics CO., LTD. | Increase or maintaining t-cell subpopulations in adoptive t-cell therapy |
| WO2020092467A1 (en) | 2018-10-30 | 2020-05-07 | Board Of Regents, The University Of Texas System | Anti-cd79b antibodies and chimeric antigen receptors and methods of use thereof |
| BR112021008289A2 (pt) | 2018-11-01 | 2021-10-26 | Juno Therapeutics, Inc. | Métodos para tratamento utilizando receptores de antígeno quimérico específico para antígeno de maturação de célula b |
| BR112021008973A8 (pt) * | 2018-11-09 | 2023-05-02 | Juno Therapeutics Inc | Receptores de células t específicos para mesotelina e uso dos mesmos em imunoterapia |
| CN116286665A (zh) * | 2018-11-16 | 2023-06-23 | 上海煦顼技术有限公司 | 嵌合抗原受体细胞分泌治疗剂 |
| WO2020102779A1 (en) | 2018-11-16 | 2020-05-22 | Albert Einstein College Of Medicine | MONOCLONAL ANTIBODIES AGAINST IgV DOMAIN OF B7-H3 AND USES THEREOF |
| JP7630832B2 (ja) * | 2018-11-19 | 2025-02-18 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｃａｒおよびｔｃｒ形質導入用のモジュール式ポリシストロニックベクター |
| US10918667B2 (en) * | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
| CA3118511C (en) | 2018-11-29 | 2024-04-30 | Vineti Inc. | Centralized and decentralized individualized medicine platform |
| KR20250116790A (ko) | 2018-12-12 | 2025-08-01 | 카이트 파마 인코포레이티드 | 키메라 항원 수용체 및 car-t 세포 및 사용 방법 |
| WO2020131586A2 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Methods for identifying neoantigens |
| EP4219688B1 (en) * | 2018-12-19 | 2026-01-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mucosal-associated invariant t (mait) cells expressing chimeric antigen receptors |
| WO2020128972A1 (en) | 2018-12-20 | 2020-06-25 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| EP3897117A1 (en) | 2018-12-21 | 2021-10-27 | Compass Therapeutics LLC | Transgenic mouse expressing common human light chain |
| EP3906057A4 (en) * | 2019-01-04 | 2022-09-14 | Marengo Therapeutics, Inc. | ANTI-TCR ANTIBODY MOLECULES AND THEIR USES |
| US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
| EP3911677A1 (en) * | 2019-01-18 | 2021-11-24 | Janssen Biotech, Inc. | Gprc5d chimeric antigen receptors and cells expressing the same |
| AU2020222346B2 (en) | 2019-02-15 | 2021-12-09 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| ES3032659T3 (en) | 2019-02-15 | 2025-07-23 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| US11321652B1 (en) | 2019-02-20 | 2022-05-03 | Vineti Inc. | Smart label devices, systems, and methods |
| CA3130754A1 (en) | 2019-02-21 | 2020-08-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| CN114127111B (zh) | 2019-02-21 | 2024-09-10 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| WO2020172553A1 (en) | 2019-02-22 | 2020-08-27 | Novartis Ag | Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors |
| WO2020168392A1 (en) | 2019-02-22 | 2020-08-27 | Garvan Institute Of Medical Research | Methods of modulating immune response via snvs of a20 that can "tune" the immune system of a subject |
| CA3126087A1 (en) | 2019-02-25 | 2020-09-03 | Novartis Ag | Mesoporous silica particles compositions for viral delivery |
| US20220154282A1 (en) | 2019-03-12 | 2022-05-19 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
| US20220142948A1 (en) | 2019-03-18 | 2022-05-12 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
| WO2020210678A1 (en) | 2019-04-12 | 2020-10-15 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| KR20200122261A (ko) | 2019-04-17 | 2020-10-27 | (주)차바이오텍 | 항암 활성이 증가된 자연살해세포 및 그의 면역 치료 용도 |
| US20220251152A1 (en) | 2019-04-24 | 2022-08-11 | Novartis Ag | Compositions and methods for selective protein degradation |
| WO2020219843A1 (en) * | 2019-04-26 | 2020-10-29 | The University Of North Carolina At Chapel Hill | Chimeric antigen receptor constructs and their use in car-t cells |
| EP3962535A1 (en) | 2019-04-30 | 2022-03-09 | CRISPR Therapeutics AG | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| SG11202112006WA (en) * | 2019-04-30 | 2021-11-29 | Memorial Sloan Kettering Cancer Center | Combination therapies |
| TW202110873A (zh) | 2019-04-30 | 2021-03-16 | 美商聖堤生物科技股份有限公司 | 嵌合受體及其使用方法 |
| CA3136742A1 (en) | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods |
| SG11202111360YA (en) | 2019-05-01 | 2021-11-29 | Juno Therapeutics Inc | Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
| CN120775051A (zh) | 2019-05-21 | 2025-10-14 | 诺华股份有限公司 | Cd19结合分子及其用途 |
| US12037378B2 (en) | 2019-05-21 | 2024-07-16 | Novartis Ag | Variant CD58 domains and uses thereof |
| WO2020243371A1 (en) | 2019-05-28 | 2020-12-03 | Massachusetts Institute Of Technology | Methods and compositions for modulating immune responses |
| CA3143271A1 (en) | 2019-06-21 | 2020-12-24 | Kite Pharma, Inc. | Tgf-.beta. receptors and methods of use |
| KR20220081972A (ko) * | 2019-07-17 | 2022-06-16 | 주식회사 큐로셀 | 이중 shrna를 이용하는 향상된 면역 세포 및 이를 포함하는 조성물 |
| JP2022541315A (ja) * | 2019-07-24 | 2022-09-22 | エウレカ セラピューティクス インコーポレイテッド | キメラ抗原受容体及びキメラ刺激受容体を発現する細胞並びにその使用 |
| JP2022543779A (ja) * | 2019-07-30 | 2022-10-14 | デンドロサイト バイオテック ピーティーワイ リミテッド | イムノコンジュゲート |
| US20220282333A1 (en) | 2019-08-13 | 2022-09-08 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
| US12421557B2 (en) | 2019-08-16 | 2025-09-23 | The Broad Institute, Inc. | Methods for predicting outcomes and treating colorectal cancer using a cell atlas |
| CN114786686A (zh) | 2019-08-18 | 2022-07-22 | 嵌合体生物工程公司 | Gold控制的转基因的联合疗法 |
| CN110627909B (zh) * | 2019-08-28 | 2021-03-30 | 中国人民解放军第二军医大学 | 一种特异性活化nk细胞的嵌合抗原受体及其应用 |
| US20220298501A1 (en) | 2019-08-30 | 2022-09-22 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| US20220332780A1 (en) | 2019-09-10 | 2022-10-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| AU2020347171A1 (en) | 2019-09-11 | 2022-03-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods comprising prostate stem cell antigen (PSCA) chimeric antigen receptors (CARs) |
| WO2021054789A1 (ko) * | 2019-09-18 | 2021-03-25 | 주식회사 에스엘바이젠 | 신규 키메라 항원 수용체 암호화 유전자가 형질도입된 유전자 변형 nk 세포주 및 그의 용도 |
| WO2021057906A1 (zh) * | 2019-09-25 | 2021-04-01 | 科济生物医药（上海）有限公司 | 表达il-15的免疫效应细胞 |
| US12297426B2 (en) | 2019-10-01 | 2025-05-13 | The Broad Institute, Inc. | DNA damage response signature guided rational design of CRISPR-based systems and therapies |
| US12394502B2 (en) | 2019-10-02 | 2025-08-19 | The General Hospital Corporation | Method for predicting HLA-binding peptides using protein structural features |
| US12195725B2 (en) | 2019-10-03 | 2025-01-14 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity |
| US11981922B2 (en) | 2019-10-03 | 2024-05-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment |
| US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
| CA3156761A1 (en) * | 2019-10-22 | 2021-04-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High affinity nanobodies targeting b7h3 (cd276) for treating multiple solid tumors |
| WO2021081232A1 (en) * | 2019-10-23 | 2021-04-29 | Cue Biopharma, Inc. | Modified cytotoxic t cells and methods of use thereof |
| CA3146917A1 (en) * | 2019-10-23 | 2021-04-29 | Anish SURI | T-cell modulatory chimeric molecules and methods of use thereof |
| US20210130438A1 (en) * | 2019-10-28 | 2021-05-06 | The Broad Institute, Inc. | Pan-cancer t cell exhaustion genes |
| CN110627903B (zh) * | 2019-10-29 | 2021-09-21 | 河南大学 | 抗cd97单克隆抗体、其可变区与恒定区序列及应用 |
| US20220387491A1 (en) * | 2019-11-04 | 2022-12-08 | Secura Bio, Inc. | Methods of making cellular therapies |
| IL293215A (en) | 2019-11-26 | 2022-07-01 | Novartis Ag | Chimeric antigen receptors that bind bcma and cd19 and their uses |
| AU2020394441B2 (en) | 2019-11-26 | 2025-11-13 | Novartis Ag | CD19 and CD22 chimeric antigen receptors and uses thereof |
| WO2021107726A1 (ko) * | 2019-11-28 | 2021-06-03 | 주식회사 센트릭스바이오 | Cd300c 항원 또는 그의 수용체에 특이적으로 결합하는 키메라 항원 수용체 |
| CN115087670B (zh) * | 2019-12-11 | 2025-10-28 | 西拉格国际有限责任公司 | 包含ltbr和edb结合结构域的多特异性结合分子及其用途 |
| WO2021127428A1 (en) * | 2019-12-18 | 2021-06-24 | Albert Einstein College Of Medicine | Chimeric antigen receptors targeting b7-h3 (cd276) and associated methods |
| BR112022011902A2 (pt) | 2019-12-20 | 2022-09-06 | Novartis Ag | Terapias de combinação |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| US20230056856A1 (en) * | 2020-01-08 | 2023-02-23 | Obsidian Therapeutics, Inc. | Compositions and methods for tunable regulation of transcription |
| CN115427084A (zh) * | 2020-01-10 | 2022-12-02 | T细胞受体治疗公司 | 用于自身免疫调节的组合物和方法 |
| US12165747B2 (en) | 2020-01-23 | 2024-12-10 | The Broad Institute, Inc. | Molecular spatial mapping of metastatic tumor microenvironment |
| US20230111593A1 (en) | 2020-02-14 | 2023-04-13 | Novartis Ag | Method of predicting response to chimeric antigen receptor therapy |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
| CA3173737A1 (en) | 2020-02-27 | 2021-09-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| TW202146441A (zh) | 2020-02-27 | 2021-12-16 | 瑞士商諾華公司 | 製備表現嵌合抗原受體的細胞之方法 |
| EP4142778A4 (en) * | 2020-04-30 | 2024-06-05 | Board of Regents, The University of Texas System | ANTI-CD79B ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOF |
| AU2021268953A1 (en) * | 2020-05-05 | 2022-12-08 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using CD70 specific fusion proteins |
| CA3169949A1 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| US12043654B2 (en) | 2020-06-02 | 2024-07-23 | Innovative Cellular Therapeutics Holdings, Ltd. | Anti-GCC antibody and CAR thereof for treating digestive system cancer |
| KR20220166837A (ko) * | 2020-06-11 | 2022-12-19 | 난징 바이오흐엥 바이오테크 씨오., 엘티디 | Nk억제 분자를 발현하는 조작된 면역 세포 및 그 용도 |
| WO2021256522A1 (ja) * | 2020-06-17 | 2021-12-23 | 国立大学法人京都大学 | キメラ抗原受容体発現免疫担当細胞 |
| US20230416359A1 (en) * | 2020-06-17 | 2023-12-28 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Olfactory receptors for use as targets for antigen binding molecules to detect and treat cancer |
| JP2023530997A (ja) * | 2020-06-19 | 2023-07-20 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｂｓｔ２ロングアイソフォームを標的化する抗ｂｓｔ２抗体 |
| CN116813777A (zh) | 2020-06-22 | 2023-09-29 | 恩格姆生物制药公司 | Lair-1结合剂及其使用方法 |
| CN115916199A (zh) | 2020-06-23 | 2023-04-04 | 诺华股份有限公司 | 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案 |
| JP2023531531A (ja) | 2020-06-26 | 2023-07-24 | ジュノ セラピューティクス ゲーエムベーハー | 組換え受容体を条件付きで発現する操作されたｔ細胞、関連ポリヌクレオチド、および方法 |
| WO2022016119A1 (en) | 2020-07-17 | 2022-01-20 | Simurx, Inc. | Chimeric myd88 receptors for redirecting immunosuppressive signaling and related compositions and methods |
| CN116134027B (zh) | 2020-08-03 | 2025-01-24 | 诺华股份有限公司 | 杂芳基取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
| US12077594B2 (en) * | 2020-08-05 | 2024-09-03 | Synthekine, Inc. | IL2RG binding molecules and methods of use |
| KR102846963B1 (ko) | 2020-08-05 | 2025-08-18 | 신테카인, 인크. | IL27Rα 결합 분자 및 사용 방법 |
| CN116723859A (zh) | 2020-08-05 | 2023-09-08 | 辛德凯因股份有限公司 | IL27Rα结合分子及使用方法 |
| JP7767391B2 (ja) | 2020-08-05 | 2025-11-11 | シンセカイン インコーポレイテッド | ＩＬ１０Ｒａ結合分子および使用方法 |
| US12122839B2 (en) | 2020-08-05 | 2024-10-22 | Synthekine, Inc. | IFNGR binding synthetic cytokines and methods of use |
| WO2022031890A1 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Ifngr2 binding molecules and methods of use |
| MX2023001491A (es) * | 2020-08-05 | 2023-03-08 | Synthekine Inc | Moleculas de union a gp130 y metodos de uso. |
| US12234291B2 (en) | 2020-08-05 | 2025-02-25 | Synthekine, Inc. | IL2RB binding molecules and methods of use |
| WO2022032022A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il10 receptor binding molecules and methods of use |
| JP7524465B2 (ja) | 2020-08-14 | 2024-07-29 | カイト ファーマ インコーポレイテッド | 免疫細胞機能の改善 |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| US20230302155A1 (en) | 2020-08-21 | 2023-09-28 | Novartis Ag | Compositions and methods for in vivo generation of car expressing cells |
| US20240307539A1 (en) * | 2020-09-30 | 2024-09-19 | Institute Of Zoology, Chinese Academy Of Science | Egfr-targeting chimeric antigen receptor |
| CN114369168B (zh) * | 2020-10-19 | 2024-08-30 | 南京卡提医学科技有限公司 | 包含dap12和共刺激信号分子信号域的嵌合受体及其使用方法 |
| CN114426583B (zh) * | 2020-10-29 | 2023-10-10 | 中国科学技术大学 | 用于急性髓系白血病的细胞疗法的嵌合抗原受体 |
| EP4243857A1 (en) | 2020-11-13 | 2023-09-20 | Novartis AG | Combination therapies with chimeric antigen receptor (car)-expressing cells |
| WO2022109023A1 (en) * | 2020-11-17 | 2022-05-27 | Igm Biosciences, Inc. | Uses of effector cell engaging molecules with moieties of differing potencies |
| AU2021381419A1 (en) * | 2020-11-20 | 2023-06-29 | Bliss Biopharmaceutical (Hangzhou) Co., Ltd. | Modified egfr antibody with reduced affinity, drug conjugate, and use thereof |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| TW202237638A (zh) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | 烏苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法 |
| CN113980134B (zh) | 2020-12-11 | 2022-05-31 | 广州百暨基因科技有限公司 | 抗cll1抗体及其应用 |
| CN113234169B (zh) * | 2020-12-11 | 2022-11-01 | 广州百暨基因科技有限公司 | 靶向cll1嵌合抗原受体及其应用 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| TW202241479A (zh) | 2020-12-30 | 2022-11-01 | 美商安迅生物製藥公司 | 遞送外來抗原之溶瘤病毒及表現靶向外來抗原之嵌合受體之經工程化免疫細胞之組合療法 |
| WO2022147075A1 (en) * | 2020-12-30 | 2022-07-07 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors targeting splice variants of the extracellular matrix proteins tenascin c (tnc) and procollagen 11a1 (col11a1) |
| WO2022161355A1 (en) | 2021-01-26 | 2022-08-04 | Cytocares (Shanghai) Inc. | Chimeric antigen receptor (car) constructs and nk cells expressing car constructs |
| WO2022161454A1 (zh) * | 2021-01-29 | 2022-08-04 | 明慧医药（杭州）有限公司 | 抗原结合蛋白及其用途 |
| CN114853900A (zh) * | 2021-02-03 | 2022-08-05 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
| CN112851826B (zh) * | 2021-02-10 | 2023-08-11 | 上海煦顼技术有限公司 | Upk2嵌合抗原受体及其尿道癌的治疗 |
| KR102671410B1 (ko) * | 2021-03-03 | 2024-06-04 | 진화섭 | RANK 리간드(RANK ligand)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도 |
| AU2022234333B2 (en) | 2021-03-11 | 2025-05-22 | Kite Pharma, Inc. | Improving immune cell function |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| US20240384293A1 (en) | 2021-04-27 | 2024-11-21 | Novartis Ag | Viral vector production system |
| US12016923B2 (en) | 2021-06-01 | 2024-06-25 | Triumvira Immunologics Usa, Inc. | Claudin 18.2 T cell-antigen couplers and uses thereof |
| US20250000973A1 (en) | 2021-08-20 | 2025-01-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| EP4141028A1 (en) | 2021-08-31 | 2023-03-01 | Johann-Wolfgang-Goethe-Universität Frankfurt am Main | Personalized vnar-based chimeric antigen receptors (vnar-car) for the treatment of clonal b-and t cell malignancies, and methods for producing vnar-cars |
| US11615874B1 (en) | 2021-09-30 | 2023-03-28 | Vineti Inc. | Personalized medicine and therapies platform |
| EP4416292A2 (en) | 2021-10-14 | 2024-08-21 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
| CN114015674B (zh) | 2021-11-02 | 2024-08-30 | 辉大(上海)生物科技有限公司 | 一种CRISPR-Cas12i系统 |
| WO2023177954A1 (en) * | 2022-03-18 | 2023-09-21 | University Of Rochester | Combination therapy for treatment of cancer, methods and systems of delivery thereof |
| CN114805584B (zh) * | 2022-06-30 | 2022-09-09 | 上海优替济生生物医药有限公司 | 抗原结合蛋白及其用途 |
| JPWO2024014470A1 (enExample) * | 2022-07-13 | 2024-01-18 | ||
| EP4577234A1 (en) | 2022-08-26 | 2025-07-02 | Kite Pharma, Inc. | Improving immune cell function |
| KR20250067174A (ko) | 2022-09-15 | 2025-05-14 | 노파르티스 아게 | 키메라 항원 수용체 요법을 사용한 자가면역 장애의 치료 |
| WO2024077256A1 (en) | 2022-10-07 | 2024-04-11 | The General Hospital Corporation | Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins |
| CN120112650A (zh) | 2022-10-26 | 2025-06-06 | 诺华股份有限公司 | 慢病毒配制品 |
| EP4623073A2 (en) | 2022-11-21 | 2025-10-01 | Iovance Biotherapeutics, Inc. | Methods for assessing proliferation potency of gene-edited t cells |
| WO2024124044A1 (en) | 2022-12-07 | 2024-06-13 | The Brigham And Women’S Hospital, Inc. | Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression |
| WO2024178397A2 (en) | 2023-02-24 | 2024-08-29 | Elevatebio Technologies, Inc. | Modified immune effector cells and methods of use |
| AU2024233625A1 (en) | 2023-03-03 | 2025-09-18 | Arsenal Biosciences, Inc. | Systems targeting psma and ca9 |
| WO2024215987A1 (en) * | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES |
| WO2024215989A1 (en) * | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | ENGINEERED IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-2/IL-15 RECEPTOR βγ AGONISTS |
| AU2024310260A1 (en) | 2023-06-29 | 2025-12-11 | Dispatch Biotherapeutics, Inc. | Synthetic cytokine receptors |
| TW202521564A (zh) | 2023-08-14 | 2025-06-01 | 美商英特利亞醫療公司 | 用於基於細胞之療法的ｃｄ７０ ｃａｒ－ｔ組合物及方法 |
| EP4520346A1 (en) | 2023-09-06 | 2025-03-12 | Gyncentrum Sp. z o.o. | Cells, methods and systems for use in the treatment of a cancer with dual-car-t |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| WO2025059533A1 (en) | 2023-09-13 | 2025-03-20 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2025097055A2 (en) | 2023-11-02 | 2025-05-08 | The Broad Institute, Inc. | Compositions and methods of use of t cells in immunotherapy |
| WO2025117544A1 (en) | 2023-11-29 | 2025-06-05 | The Broad Institute, Inc. | Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof |
| WO2026006767A1 (en) | 2024-06-28 | 2026-01-02 | Dispatch Biotherapeutics, Inc. | Tethered il-9/il-9r and related engineered cells and methods |
| WO2026008700A1 (en) | 2024-07-03 | 2026-01-08 | Immunofusion Bv | Il7r alpha signalling domain, chimeric antigen receptor and uses thereof |
Family Cites Families (295)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US504048A (en) | 1893-08-29 | Sulky | ||
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US4433059A (en) | 1981-09-08 | 1984-02-21 | Ortho Diagnostic Systems Inc. | Double antibody conjugate |
| US4444878A (en) | 1981-12-21 | 1984-04-24 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
| DE3381783D1 (de) | 1982-03-03 | 1990-09-13 | Genentech Inc | Menschliches antithrombin iii, dns sequenzen dafuer, expressions- und klonierungsvektoren die solche sequenzen enthalten und damit transformierte zellkulturen, verfahren zur expression von menschlichem antithrombin iii und diese enthaltende pharmazeutische zusammensetzungen. |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4851332A (en) | 1985-04-01 | 1989-07-25 | Sloan-Kettering Institute For Cancer Research | Choriocarcinoma monoclonal antibodies and antibody panels |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5869620A (en) | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
| JPH021556A (ja) | 1988-06-09 | 1990-01-05 | Snow Brand Milk Prod Co Ltd | ハイブリッド抗体及びその作製方法 |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| AU6290090A (en) | 1989-08-29 | 1991-04-08 | University Of Southampton | Bi-or trispecific (fab)3 or (fab)4 conjugates |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5273743A (en) | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| GB9012995D0 (en) | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
| US5582996A (en) | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| DE4118120A1 (de) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung |
| US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| US6511663B1 (en) | 1991-06-11 | 2003-01-28 | Celltech R&D Limited | Tri- and tetra-valent monospecific antigen-binding proteins |
| WO1992022653A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | Method for making humanized antibodies |
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| ES2202310T3 (es) | 1991-12-13 | 2004-04-01 | Xoma Corporation | Metodos y materiales para la preparacion de dominios variables de anticuerpos modificados y sus usos terapeuticos. |
| DK0654085T3 (da) | 1992-01-23 | 1997-09-22 | Merck Patent Gmbh | Monomere og dimere antistof-fragment-fusionsproteiner |
| ATE503496T1 (de) | 1992-02-06 | 2011-04-15 | Novartis Vaccines & Diagnostic | Biosynthetisches bindeprotein für tumormarker |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| US5646253A (en) | 1994-03-08 | 1997-07-08 | Memorial Sloan-Kettering Cancer Center | Recombinant human anti-LK26 antibodies |
| AU675223B2 (en) | 1992-05-08 | 1997-01-30 | Creative Biomolecules, Inc. | Chimeric multivalent protein analogues and methods of use thereof |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| DE69330523T4 (de) | 1992-08-21 | 2012-08-23 | Vrije Universiteit Brussel | Immunoglobuline ohne leichte ketten |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| EP0672068A4 (en) | 1992-09-25 | 1997-02-26 | Commw Scient Ind Res Org | TARGET MOLECULES BINDING POLYPEPTIDES. |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| GB9221657D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant bispecific antibodies |
| US5837821A (en) | 1992-11-04 | 1998-11-17 | City Of Hope | Antibody construct |
| GB9323648D0 (en) | 1992-11-23 | 1994-01-05 | Zeneca Ltd | Proteins |
| DE69329974T2 (de) | 1992-12-04 | 2001-07-19 | Medical Research Council, London | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US6476198B1 (en) | 1993-07-13 | 2002-11-05 | The Scripps Research Institute | Multispecific and multivalent antigen-binding polypeptide molecules |
| US5635602A (en) | 1993-08-13 | 1997-06-03 | The Regents Of The University Of California | Design and synthesis of bispecific DNA-antibody conjugates |
| WO1995009917A1 (en) | 1993-10-07 | 1995-04-13 | The Regents Of The University Of California | Genetically engineered bispecific tetravalent antibodies |
| WO1995014042A1 (en) | 1993-11-16 | 1995-05-26 | Pola Chemical Industries Inc. | Antihuman tyrosinase monoclonal antibody |
| WO1995014023A1 (en) | 1993-11-19 | 1995-05-26 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| ATE191218T1 (de) | 1993-12-17 | 2000-04-15 | Novartis Ag | Rapamycin-derivate als immunosuppressoren |
| US5635388A (en) | 1994-04-04 | 1997-06-03 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| EP0756604A1 (en) | 1994-04-22 | 1997-02-05 | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services | Melanoma antigens |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| WO1996013583A2 (en) | 1994-10-20 | 1996-05-09 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Targeted hetero-association of recombinant proteins to multi-functional complexes |
| DE69605181T3 (de) | 1995-01-18 | 2006-08-24 | Roche Diagnostics Gmbh | Antikörper gegen cd30, die proteolytische spaltung und abgabe des membrangebundenen cd30 antigens verhindern |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| CA2222055A1 (en) | 1995-05-23 | 1996-11-28 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Multimeric proteins |
| PL184731B1 (pl) | 1995-06-09 | 2002-12-31 | Novartis Ag | Pochodne rapamycyny, zastosowanie pochodnych rapamycyny i kompozycja farmaceutyczna |
| FR2736550B1 (fr) | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
| AU6873396A (en) | 1995-10-16 | 1997-05-07 | Unilever N.V. | A bifunctional or bivalent antibody fragment analogue |
| DE19608769C1 (de) | 1996-03-07 | 1997-04-10 | Univ Eberhard Karls | Antikörper BV10A4H2 |
| WO1997038102A1 (en) | 1996-04-04 | 1997-10-16 | Unilever Plc | Multivalent and multispecific antigen-binding protein |
| EP0937082A2 (en) | 1996-07-12 | 1999-08-25 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
| US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| JP4440344B2 (ja) | 1996-08-16 | 2010-03-24 | シェーリング コーポレイション | 哺乳動物細胞表面抗原；関連試薬 |
| US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
| JP2001510987A (ja) | 1996-10-25 | 2001-08-07 | アメリカ合衆国 | 哺乳動物のＣＤ９７αサブユニットを含む炎症および脈管形成を阻害するための方法および組成物 |
| CA2288992C (en) | 1997-04-30 | 2012-06-12 | Enzon, Inc. | Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof |
| US20030207346A1 (en) | 1997-05-02 | 2003-11-06 | William R. Arathoon | Method for making multispecific antibodies having heteromultimeric and common components |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| CA2304254C (en) | 1997-06-11 | 2012-05-22 | Hans Christian Thogersen | Trimerising module |
| EP0985039B1 (en) | 1997-06-12 | 2008-02-20 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
| TW557297B (en) | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
| CA2308114A1 (en) | 1997-10-21 | 1999-04-29 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins tr11, tr11sv1, and tr11sv2 |
| ATE461282T1 (de) | 1997-10-27 | 2010-04-15 | Bac Ip Bv | Multivalente antigenbindende proteine |
| CA2317727C (en) | 1998-01-23 | 2013-01-08 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Multipurpose antibody derivatives |
| IL137409A0 (en) | 1998-02-09 | 2001-07-24 | Genentech Inc | Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same |
| HUP9900956A2 (hu) | 1998-04-09 | 2002-04-29 | Aventis Pharma Deutschland Gmbh. | Egyláncú, több antigéntkötőhely kialakítására képes molekulák, előállításuk és alkalmazásuk |
| DE69925909T2 (de) | 1998-04-15 | 2006-05-11 | Brigham & Women's Hospital, Inc., Boston | T-zell inhibierende rezeptorzusammensetzungen sowie deren verwendung |
| DE19819846B4 (de) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
| GB9812545D0 (en) | 1998-06-10 | 1998-08-05 | Celltech Therapeutics Ltd | Biological products |
| US6803448B1 (en) | 1998-07-22 | 2004-10-12 | Vanderbilt University | GBS toxin receptor |
| ES2207278T3 (es) | 1998-07-28 | 2004-05-16 | Micromet Ag | Heterominicuerpos. |
| US6333396B1 (en) | 1998-10-20 | 2001-12-25 | Enzon, Inc. | Method for targeted delivery of nucleic acids |
| US6528481B1 (en) | 1999-02-16 | 2003-03-04 | The Burnam Institute | NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods |
| US7534866B2 (en) | 2005-10-19 | 2009-05-19 | Ibc Pharmaceuticals, Inc. | Methods and compositions for generating bioactive assemblies of increased complexity and uses |
| US7527787B2 (en) | 2005-10-19 | 2009-05-05 | Ibc Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
| EP1196186B1 (en) | 1999-07-12 | 2007-10-31 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs |
| NZ517782A (en) | 1999-08-17 | 2004-01-30 | Biogen Inc | A beta-cell activating factor receptor belonging to the TNF family is used as a pharmaceutical agent and in the treatment of disease |
| EP1212331B1 (en) | 1999-08-24 | 2004-04-21 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| JP4689124B2 (ja) | 1999-09-30 | 2011-05-25 | 協和発酵キリン株式会社 | ガングリオシドｇｄ３に対するヒト型相補性決定領域移植抗体およびガングリオシドｇｄ３に対する抗体の誘導体 |
| WO2001029058A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| ES2302726T3 (es) | 2000-02-24 | 2008-08-01 | Invitrogen Corporation | Estimulacion y concentracion simultanea de celulas. |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| HUP0300369A2 (hu) | 2000-04-11 | 2003-06-28 | Genentech, Inc. | Többértékű antitestek és alkalmazásuk |
| AU2001264946A1 (en) | 2000-05-24 | 2001-12-03 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
| WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
| WO2002002781A1 (en) | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Heterodimeric fusion proteins |
| CN1461344A (zh) | 2000-07-25 | 2003-12-10 | 免疫医疗公司 | 多价靶结合蛋白 |
| CN1308447C (zh) | 2000-10-20 | 2007-04-04 | 中外制药株式会社 | 低分子化的激动剂抗体 |
| US7090843B1 (en) | 2000-11-28 | 2006-08-15 | Seattle Genetics, Inc. | Recombinant anti-CD30 antibodies and uses thereof |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| WO2002072635A2 (en) | 2001-03-13 | 2002-09-19 | University College London | Specific binding members |
| CN1294148C (zh) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | 环状单链三特异抗体 |
| ATE477280T1 (de) | 2001-06-28 | 2010-08-15 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
| US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
| PT1419179E (pt) | 2001-08-10 | 2010-03-16 | Univ Aberdeen | Domínios de ligação de antigenes |
| US8298769B2 (en) | 2001-08-23 | 2012-10-30 | Rsr Limited | Epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto |
| DE60124912T2 (de) | 2001-09-14 | 2007-06-14 | Affimed Therapeutics Ag | Multimerische, einzelkettige, Tandem-Fv-Antikörper |
| EP1470159B1 (en) | 2001-12-04 | 2013-08-07 | Dana-Farber Cancer Institute, Inc. | Antibody to latent membrane proteins and uses thereof |
| WO2003049684A2 (en) | 2001-12-07 | 2003-06-19 | Centocor, Inc. | Pseudo-antibody constructs |
| US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| CN100522967C (zh) | 2002-02-01 | 2009-08-05 | 阿里亚德基因治疗公司 | 含磷化合物及其应用 |
| CA2478011C (en) | 2002-03-01 | 2013-05-21 | Immunomedics, Inc. | Bispecific antibody point mutations for enhancing rate of clearance |
| GB0208104D0 (en) | 2002-04-09 | 2002-05-22 | Univ Dundee | Method |
| US8030461B2 (en) | 2002-04-15 | 2011-10-04 | Chugai Seiyaku Kabushiki Kaisha | Methods for constructing scDb libraries |
| US20040047858A1 (en) | 2002-09-11 | 2004-03-11 | Blumberg Richard S. | Therapeutic anti-BGP(C-CAM1) antibodies and uses thereof |
| JP4744147B2 (ja) | 2002-11-26 | 2011-08-10 | ベー・エル・アー・ハー・エム・エス・ゲーエムベーハー | アフィニティー精製抗体を用いた甲状腺刺激ホルモン受容体自己抗体の同定 |
| ES2367430T3 (es) | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
| GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| GB0305702D0 (en) | 2003-03-12 | 2003-04-16 | Univ Birmingham | Bispecific antibodies |
| WO2004087758A2 (en) | 2003-03-26 | 2004-10-14 | Neopharm, Inc. | Il 13 receptor alpha 2 antibody and methods of use |
| JP2006526408A (ja) | 2003-04-22 | 2006-11-24 | アイビーシー、ファーマシューティカルズ | 多価タンパク質複合体 |
| CU23403A1 (es) | 2003-04-23 | 2009-08-04 | Centro Inmunologia Molecular | Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores |
| KR20060052681A (ko) | 2003-05-23 | 2006-05-19 | 와이어쓰 | Ｇｉｔｒ 리간드, ｇｉｔｒ 리간드-연관 분자, 항체 및그의 용도 |
| MXPA05014030A (es) | 2003-06-27 | 2007-02-13 | Diadexus Inc | Composiciones de anticuerpo pro 104 y metodos de uso. |
| NZ544924A (en) | 2003-06-27 | 2009-03-31 | Biogen Idec Inc | Modified binding molecules comprising connecting peptides |
| EP1638510B1 (en) | 2003-07-01 | 2015-09-02 | Immunomedics, Inc. | Multivalent carriers of bi-specific antibodies |
| EP1660126A1 (en) | 2003-07-11 | 2006-05-31 | Schering Corporation | Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer |
| US7696322B2 (en) | 2003-07-28 | 2010-04-13 | Catalent Pharma Solutions, Inc. | Fusion antibodies |
| ES2458636T3 (es) | 2003-08-18 | 2014-05-06 | Medimmune, Llc | Humanización de anticuerpos |
| AU2004280333A1 (en) | 2003-08-22 | 2005-04-21 | Medimmune, Llc | Humanization of antibodies |
| JPWO2005035586A1 (ja) | 2003-10-08 | 2007-11-22 | 協和醗酵工業株式会社 | 融合蛋白質組成物 |
| WO2005035577A1 (ja) | 2003-10-08 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | ガングリオシドｇｄ３に特異的に結合する抗体組成物 |
| US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| US7220755B2 (en) | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
| EP1692318A4 (en) | 2003-12-02 | 2008-04-02 | Genzyme Corp | COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LUNG CANCER |
| WO2005062916A2 (en) | 2003-12-22 | 2005-07-14 | Centocor, Inc. | Methods for generating multimeric molecules |
| GB0329825D0 (en) | 2003-12-23 | 2004-01-28 | Celltech R&D Ltd | Biological products |
| US20050266425A1 (en) | 2003-12-31 | 2005-12-01 | Vaccinex, Inc. | Methods for producing and identifying multispecific antibodies |
| US8383575B2 (en) | 2004-01-30 | 2013-02-26 | Paul Scherrer Institut | (DI)barnase-barstar complexes |
| SI2511297T1 (sl) | 2004-02-06 | 2015-07-31 | Morphosys Ag | Proti -CD38 humana protitelesa in njihova uporaba |
| GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
| EP2295588B1 (en) | 2004-05-27 | 2018-03-07 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses thefor |
| US20060002932A1 (en) | 2004-06-04 | 2006-01-05 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
| JP2008512352A (ja) | 2004-07-17 | 2008-04-24 | イムクローン システムズ インコーポレイティド | 新規な四価の二重特異性抗体 |
| US20060204493A1 (en) | 2004-09-02 | 2006-09-14 | Genentech, Inc. | Heteromultimeric molecules |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| US7812135B2 (en) | 2005-03-25 | 2010-10-12 | Tolerrx, Inc. | GITR-binding antibodies |
| AU2006232287B2 (en) | 2005-03-31 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| CN101484182B (zh) | 2005-04-06 | 2014-06-11 | Ibc药品公司 | 由同二聚体、同四聚体或二聚体的二聚体组成的稳定连接复合体的生产方法及用途 |
| AU2006236439B2 (en) | 2005-04-15 | 2012-05-03 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| AU2006244885B2 (en) | 2005-05-09 | 2011-03-31 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| NZ563263A (en) | 2005-05-17 | 2010-04-30 | Univ Connecticut | Composition and methods for immunomodulation in an organism |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US20060263367A1 (en) | 2005-05-23 | 2006-11-23 | Fey Georg H | Bispecific antibody devoid of Fc region and method of treatment using same |
| EP1726650A1 (en) | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| NZ564098A (en) | 2005-06-15 | 2010-04-30 | Schering Corp | Anti-IGF1R antibody formulations |
| AU2006265108C1 (en) | 2005-07-01 | 2013-01-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
| US20070036773A1 (en) | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| NZ612578A (en) | 2005-08-19 | 2014-11-28 | Abbvie Inc | Dual variable domain immunoglobin and uses thereof |
| EP1757622B1 (en) | 2005-08-26 | 2009-12-23 | PLS Design GmbH | Bivalent IgY antibody constructs for diagnostic and therapeutic applications |
| WO2007044729A2 (en) | 2005-10-07 | 2007-04-19 | Exelixis, Inc. | N- (3-amino-quinoxalin-2-yl) -sulfonamide derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
| WO2007044887A2 (en) | 2005-10-11 | 2007-04-19 | Transtarget, Inc. | Method for producing a population of homogenous tetravalent bispecific antibodies |
| WO2007062466A1 (en) | 2005-11-29 | 2007-06-07 | The University Of Sydney | Demibodies: dimerisation-activated therapeutic agents |
| CN103204931B (zh) | 2005-12-08 | 2016-08-03 | 米德列斯公司 | 抗岩藻糖基-gm1的人单克隆抗体及使用抗岩藻糖基-gm1抗体的方法 |
| EP1806365A1 (en) | 2006-01-05 | 2007-07-11 | Boehringer Ingelheim International GmbH | Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them |
| CA2636111C (en) | 2006-01-13 | 2018-04-03 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells |
| WO2007133822A1 (en) | 2006-01-19 | 2007-11-22 | Genzyme Corporation | Gitr antibodies for the treatment of cancer |
| MX2008010561A (es) | 2006-02-15 | 2009-03-02 | Imclone Systems Inc | Anticuerpos funcionales. |
| US7951918B2 (en) | 2006-03-17 | 2011-05-31 | Biogen Idec Ma Inc. | Stabilized polypeptide compositions |
| ATE509033T1 (de) | 2006-03-20 | 2011-05-15 | Univ California | Manipulierte anti-prostatastammzellenantigen (psca)-antikörper für krebs-targeting |
| WO2007112362A2 (en) | 2006-03-24 | 2007-10-04 | The Regents Of The University Of California | Construction of a multivalent scfv through alkyne-azide 1,3-dipolar cycloaddition |
| AR060070A1 (es) | 2006-03-24 | 2008-05-21 | Merck Patent Gmbh | Dominios proteicos heterodimericos obtenidos por ingenieria |
| US8603466B2 (en) | 2006-03-29 | 2013-12-10 | King's College London | Agonist antibodies against TSHR |
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| TWI395754B (zh) | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之ｃ-ｋｉｔ抗體 |
| US8501185B2 (en) | 2006-05-25 | 2013-08-06 | Bayer Healthcare Llc | Dimeric molecular complexes |
| US20070274985A1 (en) | 2006-05-26 | 2007-11-29 | Stefan Dubel | Antibody |
| EP3805269A1 (en) | 2006-06-12 | 2021-04-14 | Aptevo Research and Development LLC | Single-chain multivalent binding proteins with effector function |
| US7741446B2 (en) | 2006-08-18 | 2010-06-22 | Armagen Technologies, Inc. | Fusion antibodies that cross the blood-brain barrier in both directions |
| PL2059533T3 (pl) | 2006-08-30 | 2013-04-30 | Genentech Inc | Przeciwciała wieloswoiste |
| AU2007304590A1 (en) | 2006-10-04 | 2008-04-10 | Cancer Research Technology Limited | Generation of a cancer-specific immune response toward MUC1 and cancer specific MUC1 antibodies |
| FR2906808B1 (fr) | 2006-10-10 | 2012-10-05 | Univ Nantes | Utilisation d'anticorps monoclonaux specifiques de la forme o-acetylee du ganglioside gd2 dans le traitement de certains cancers |
| CN101965363A (zh) | 2006-11-02 | 2011-02-02 | 丹尼尔·J·卡鹏 | 具有活动部分的杂合免疫球蛋白 |
| WO2008101234A2 (en) | 2007-02-16 | 2008-08-21 | Sloan-Kettering Institute For Cancer Research | Anti ganglioside gd3 antibodies and uses thereof |
| US7635753B2 (en) | 2007-02-19 | 2009-12-22 | Wisconsin Alumni Research Foundation | Prostate cancer and melanoma antigens |
| AU2008234530B2 (en) | 2007-03-29 | 2013-03-28 | Technion Research & Development Foundation Ltd. | Antibodies, methods and kits for diagnosing and treating melanoma |
| ES2593484T3 (es) | 2007-03-29 | 2016-12-09 | Genmab A/S | Anticuerpos biespecíficos y métodos de producción de los mismos |
| CA2682605A1 (en) | 2007-04-18 | 2008-10-30 | Zymogenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| JP2010190572A (ja) | 2007-06-01 | 2010-09-02 | Sapporo Medical Univ | ＩＬ１３Ｒａ２に対する抗体およびこれを含む診断・治療薬 |
| CA2691357C (en) | 2007-06-18 | 2014-09-23 | N.V. Organon | Antibodies to human programmed death receptor pd-1 |
| EP2724727A1 (en) | 2007-06-27 | 2014-04-30 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Complexes of IL-15 and IL-15R alpha and uses thereof |
| EP2175884B8 (en) | 2007-07-12 | 2017-02-22 | GITR, Inc. | Combination therapies employing gitr binding molecules |
| CA2694990A1 (en) | 2007-07-31 | 2009-02-05 | Merck Sharp & Dohme Corp. | Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders |
| EP2626371A1 (en) | 2007-07-31 | 2013-08-14 | MedImmune, LLC | Multispecific epitope binding proteins and uses thereof |
| ES2628395T3 (es) | 2007-08-15 | 2017-08-02 | Bayer Pharma Aktiengesellschaft | Anticuerpo regulado por proteasa |
| US9416165B2 (en) | 2007-10-26 | 2016-08-16 | The Regents Of The University Of California | Methods of inhibiting viral replication and improving T cell function employing soluble Tim-3 inhibitors |
| KR20100097716A (ko) | 2007-11-27 | 2010-09-03 | 아블린쓰 엔.브이. | 이종이량체 사이토킨 및/또는 이의 수용체에 대한 아미노산 서열과 이를 포함하는 폴리펩티드 |
| GB2468232B (en) | 2007-11-30 | 2012-10-24 | Glaxo Group Ltd | Antigen-bindng constructs |
| US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| PL2235064T3 (pl) | 2008-01-07 | 2016-06-30 | Amgen Inc | Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych |
| WO2009091826A2 (en) * | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| EP2242773B1 (en) | 2008-02-11 | 2017-06-14 | Cure Tech Ltd. | Monoclonal antibodies for tumor treatment |
| JP2011512395A (ja) | 2008-02-21 | 2011-04-21 | アストラゼネカ アクチボラグ | 組合せ療法２３８ |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| AR071891A1 (es) | 2008-05-30 | 2010-07-21 | Imclone Llc | Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) |
| KR20110044992A (ko) | 2008-07-02 | 2011-05-03 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | ＴＧＦ-β 길항제 다중-표적 결합 단백질 |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| HUE027525T2 (en) | 2008-08-25 | 2016-11-28 | Amplimmune Inc | PD-1 Antagonist preparations and their use |
| MX2011002250A (es) | 2008-08-25 | 2011-08-17 | Amplimmune Inc | Antagonistas de muerte celular programada-1 y métodos de uso de los mismos. |
| CN102149820B (zh) | 2008-09-12 | 2014-07-23 | 国立大学法人三重大学 | 能够表达外源gitr配体的细胞 |
| JP2012503203A (ja) | 2008-09-19 | 2012-02-02 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 基底乳癌腫の診断および処置のためのｃｓｐｇ４に対するモノクローナル抗体 |
| US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| PT2376535T (pt) | 2008-12-09 | 2017-06-23 | Hoffmann La Roche | Anticorpos anti-pd-l1 e a sua utilização para a melhoria do funcionamento das células t |
| EP3192811A1 (en) | 2009-02-09 | 2017-07-19 | Université d'Aix-Marseille | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| CN102428085B (zh) | 2009-04-03 | 2015-07-15 | 维拉斯通股份有限公司 | 作为激酶抑制剂的嘧啶取代的嘌呤化合物 |
| WO2010129304A2 (en) | 2009-04-27 | 2010-11-11 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| US8598322B2 (en) | 2009-04-30 | 2013-12-03 | Tel Hashomer Medical Research Infrastucture and Services Ltd. | Anti CEACAM1 antibodies and methods of using same |
| AU2010282280B2 (en) | 2009-08-14 | 2016-06-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of IL-15 to increase thymic output and to treat lymphopenia |
| HUE049825T2 (hu) | 2009-09-03 | 2020-10-28 | Merck Sharp & Dohme | Anti-GITR antitestek |
| US9181527B2 (en) | 2009-10-29 | 2015-11-10 | The Trustees Of Dartmouth College | T cell receptor-deficient T cell compositions |
| GB0919054D0 (en) | 2009-10-30 | 2009-12-16 | Isis Innovation | Treatment of obesity |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| EP2504028A4 (en) | 2009-11-24 | 2014-04-09 | Amplimmune Inc | SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2 |
| EP3135302A1 (en) | 2009-12-02 | 2017-03-01 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| US9023996B2 (en) | 2009-12-23 | 2015-05-05 | Synimmune Gmbh | Anti-FLT3 antibodies |
| JP5851419B2 (ja) | 2009-12-29 | 2016-02-03 | エマージェント プロダクト デベロップメント シアトル， エルエルシー | ヘテロダイマー結合タンパク質およびその使用 |
| MY171234A (en) | 2010-02-24 | 2019-10-04 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
| EP4477668A3 (en) | 2010-04-20 | 2025-03-19 | Genmab A/S | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| US9242014B2 (en) | 2010-06-15 | 2016-01-26 | The Regents Of The University Of California | Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof |
| US9163087B2 (en) | 2010-06-18 | 2015-10-20 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions |
| JP6029581B2 (ja) | 2010-06-19 | 2016-11-24 | メモリアル スローン−ケタリング キャンサー センター | 抗ｇｄ２抗体 |
| AR084469A1 (es) | 2010-07-09 | 2013-05-22 | Exelixis Inc | Combinaciones de inhibidores de quinasas para el tratamiento del cancer |
| MX2013000617A (es) | 2010-07-16 | 2013-06-13 | Piramal Entpr Ltd | Derivados sustituidos de imidazoquinolina como inhibidores de quinasa. |
| WO2012012667A2 (en) | 2010-07-21 | 2012-01-26 | Sangamo Biosciences, Inc. | Methods and compositions for modification of a hla locus |
| US9493740B2 (en) | 2010-09-08 | 2016-11-15 | Baylor College Of Medicine | Immunotherapy of cancer using genetically engineered GD2-specific T cells |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| EA201391449A1 (ru) | 2011-04-01 | 2014-03-31 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Антитела против пептидов цитозоля |
| CN107188969B (zh) | 2011-04-08 | 2021-08-27 | 美国卫生和人力服务部 | 抗-表皮生长因子受体变体iii嵌合抗原受体及其用于治疗癌症的用途 |
| US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| AR086044A1 (es) | 2011-05-12 | 2013-11-13 | Imclone Llc | Anticuerpos que se unen especificamente a un dominio extracelular de c-kit y usos de los mismos |
| CA2833820C (en) | 2011-05-27 | 2019-10-29 | Glaxo Group Limited | Bcma (cd269/tnfrsf17) -binding proteins |
| WO2013006490A2 (en) | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
| MY186267A (en) | 2011-08-11 | 2021-07-01 | Intellikine Llc | Kinase inhibitor polymorphs |
| US20130108641A1 (en) | 2011-09-14 | 2013-05-02 | Sanofi | Anti-gitr antibodies |
| EP3692794A1 (en) | 2011-09-16 | 2020-08-12 | Baylor College of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| WO2013054320A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| ITMO20110270A1 (it) | 2011-10-25 | 2013-04-26 | Sara Caldrer | Una cellula effettrice modificata per il trattamento di neoplasie esprimenti il disialonganglioside gd2 |
| WO2013060867A2 (en) | 2011-10-27 | 2013-05-02 | Genmab A/S | Production of heterodimeric proteins |
| US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| US9556271B2 (en) | 2011-12-01 | 2017-01-31 | The Brigham And Women's Hospital, Inc. | Anti-CEACAM1 recombinant antibodies for cancer therapy |
| US9439768B2 (en) | 2011-12-08 | 2016-09-13 | Imds Llc | Glenoid vault fixation |
| SG2014008304A (en) * | 2012-02-01 | 2014-06-27 | Compugen Ltd | C10rf32 antibodies, and uses thereof for treatment of cancer |
| AU2013221672B2 (en) | 2012-02-13 | 2017-11-09 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| US10040846B2 (en) | 2012-02-22 | 2018-08-07 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generating a persisting population of T cells useful for the treatment of cancer |
| AU2013256596A1 (en) | 2012-05-01 | 2014-10-09 | Genentech, Inc. | Anti-PMEL17 antibodies and immunoconjugates |
| EP4570908A3 (en) | 2012-05-25 | 2025-10-22 | The Regents of the University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| WO2013192294A1 (en) | 2012-06-20 | 2013-12-27 | Boston 3T Biotechnologies, Inc. | Cellular therapies for treating and preventing cancers and other immune system disorders |
| EP2879709B1 (en) | 2012-07-31 | 2020-01-08 | The Brigham and Women's Hospital, Inc. | Modulation of the immune response |
| TW201414837A (zh) | 2012-10-01 | 2014-04-16 | Univ Pennsylvania | 標定基質細胞以治療癌症之組合物和方法 |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| EP3679950A1 (en) | 2012-10-12 | 2020-07-15 | The Brigham and Women's Hospital, Inc. | Enhancement of the immune response |
| WO2014093595A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas component systems, methods and compositions for sequence manipulation |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| DK3064585T3 (da) | 2012-12-12 | 2020-04-27 | Broad Inst Inc | Konstruering og optimering af forbedrede systemer, fremgangsmåder og enzymsammensætninger til sekvensmanipulation |
| US20160008399A1 (en) | 2013-01-14 | 2016-01-14 | Fred Hutchinson Cancer Research Center | Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse |
| WO2014145252A2 (en) * | 2013-03-15 | 2014-09-18 | Milone Michael C | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| ES2939760T3 (es) | 2014-03-15 | 2023-04-26 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico para antígenos |
| TW202508628A (zh) * | 2016-07-28 | 2025-03-01 | 瑞士商諾華公司 | 嵌合抗原受體及pd-1抑制劑之組合療法 |
| AU2020394441B2 (en) * | 2019-11-26 | 2025-11-13 | Novartis Ag | CD19 and CD22 chimeric antigen receptors and uses thereof |
| CN120917046A (zh) * | 2022-10-18 | 2025-11-07 | 凯特制药公司 | 新型cd19结合剂、包含所述cd19结合剂的car-t构建体及其使用方法 |
| WO2024086191A2 (en) * | 2022-10-18 | 2024-04-25 | Kite Pharma, Inc. | Car-t constructs comprising a novel cd19 binder combined with il18 and methods of using the same |
-
2015
- 2015-03-13 ES ES15712503T patent/ES2939760T3/es active Active
- 2015-03-13 EP EP19169356.3A patent/EP3593812A3/en active Pending
- 2015-03-13 EP EP15712503.0A patent/EP3119423B1/en active Active
- 2015-03-13 CN CN201580013987.3A patent/CN106163547A/zh active Pending
- 2015-03-13 WO PCT/US2015/020606 patent/WO2015142675A2/en not_active Ceased
- 2015-03-13 US US15/126,036 patent/US20170335281A1/en not_active Abandoned
- 2015-03-13 JP JP2016557287A patent/JP2017513818A/ja active Pending
-
2019
- 2019-07-05 JP JP2019126002A patent/JP6860623B2/ja active Active
- 2019-10-11 US US16/599,988 patent/US20200283729A1/en active Pending
-
2021
- 2021-03-26 JP JP2021053240A patent/JP7526121B2/ja active Active
-
2024
- 2024-07-19 JP JP2024115421A patent/JP2024164002A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017513818A5 (enExample) | ||
| RU2019133286A (ru) | Биомаркеры и средства терапии на основе т-клеток с car с повышенной эффективностью | |
| JP2020513828A5 (enExample) | ||
| IL295878A (en) | Methods for producing cells expressing a chimeric antigen receptor | |
| JP2020500530A5 (enExample) | ||
| JP2018527008A5 (enExample) | ||
| JP2024518011A (ja) | 多様な免疫細胞のための単鎖および多鎖合成抗原受容体 | |
| US20190321404A1 (en) | Novel chimeric antigen receptor and use thereof | |
| IL295604A (en) | Methods of making chimeric antigen receptor-expressing cells | |
| CN112771167B (zh) | 表达有趋化因子的细胞及用途 | |
| EP3822345B1 (en) | Genetically engineered cell and application thereof | |
| JP2019500394A5 (enExample) | ||
| JP2019525956A5 (enExample) | ||
| CN110582509A (zh) | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 | |
| JP2019532953A5 (enExample) | ||
| JPWO2020047452A5 (enExample) | ||
| RU2018127657A (ru) | Виды терапии на основе иммуноэффекторных клеток с улучшенной эффективностью | |
| JP2019513347A5 (enExample) | ||
| JP2017524367A5 (enExample) | ||
| EP3909590A1 (en) | Cellular immunotherapy combination | |
| EP3728322A1 (en) | Single- and multi-chain chimeric antigen receptors | |
| JPWO2021173985A5 (enExample) | ||
| JPWO2021252920A5 (enExample) | ||
| JPWO2022242700A5 (enExample) | ||
| KR20240153592A (ko) | 동종이계 치료용 세포 |