JP2020513828A5 - - Google Patents

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Publication number
JP2020513828A5
JP2020513828A5 JP2019552085A JP2019552085A JP2020513828A5 JP 2020513828 A5 JP2020513828 A5 JP 2020513828A5 JP 2019552085 A JP2019552085 A JP 2019552085A JP 2019552085 A JP2019552085 A JP 2019552085A JP 2020513828 A5 JP2020513828 A5 JP 2020513828A5
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JP
Japan
Prior art keywords
tet2
cancer
cell
genes
related gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019552085A
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English (en)
Japanese (ja)
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JP2020513828A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/023785 external-priority patent/WO2018175733A1/en
Publication of JP2020513828A publication Critical patent/JP2020513828A/ja
Publication of JP2020513828A5 publication Critical patent/JP2020513828A5/ja
Priority to JP2023051134A priority Critical patent/JP2023082071A/ja
Pending legal-status Critical Current

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JP2019552085A 2017-03-22 2018-03-22 増強された有効性を有するバイオマーカー及びcar t細胞療法 Pending JP2020513828A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023051134A JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762474991P 2017-03-22 2017-03-22
US62/474,991 2017-03-22
US201862621356P 2018-01-24 2018-01-24
US62/621,356 2018-01-24
PCT/US2018/023785 WO2018175733A1 (en) 2017-03-22 2018-03-22 Biomarkers and car t cell therapies with enhanced efficacy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023051134A Division JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Publications (2)

Publication Number Publication Date
JP2020513828A JP2020513828A (ja) 2020-05-21
JP2020513828A5 true JP2020513828A5 (enExample) 2021-04-30

Family

ID=62104357

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019552085A Pending JP2020513828A (ja) 2017-03-22 2018-03-22 増強された有効性を有するバイオマーカー及びcar t細胞療法
JP2023051134A Pending JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023051134A Pending JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Country Status (12)

Country Link
US (1) US20200087376A1 (enExample)
EP (1) EP3600392A1 (enExample)
JP (2) JP2020513828A (enExample)
KR (1) KR20190127892A (enExample)
CN (1) CN110831619A (enExample)
AU (1) AU2018240295A1 (enExample)
BR (1) BR112019019426A2 (enExample)
CA (1) CA3057306A1 (enExample)
IL (1) IL269412A (enExample)
RU (1) RU2019133286A (enExample)
SG (1) SG11201908719QA (enExample)
WO (1) WO2018175733A1 (enExample)

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EP2970426B1 (en) 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
ES2963718T3 (es) 2014-01-21 2024-04-01 Novartis Ag Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras
WO2016014565A2 (en) 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
BR112017001242A2 (pt) 2014-07-21 2017-12-05 Novartis Ag tratamento de câncer usando um receptor antigênico quimérico a cd33
WO2016014553A1 (en) 2014-07-21 2016-01-28 Novartis Ag Sortase synthesized chimeric antigen receptors
MY189028A (en) 2014-08-19 2022-01-20 Novartis Ag Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
US11459390B2 (en) 2015-01-16 2022-10-04 Novartis Ag Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
IL254817B2 (en) 2015-04-08 2023-12-01 Novartis Ag Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell
CN108473957B (zh) 2015-04-17 2024-07-16 诺华股份有限公司 改善嵌合抗原受体表达细胞的功效和扩增的方法
WO2016172583A1 (en) 2015-04-23 2016-10-27 Novartis Ag Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
JP7146632B2 (ja) 2015-07-21 2022-10-04 ノバルティス アーゲー 免疫細胞の有効性および増大を改善する方法
WO2017027392A1 (en) 2015-08-07 2017-02-16 Novartis Ag Treatment of cancer using chimeric cd3 receptor proteins
US11747346B2 (en) 2015-09-03 2023-09-05 Novartis Ag Biomarkers predictive of cytokine release syndrome
JP2018536436A (ja) 2015-12-04 2018-12-13 ノバルティス アーゲー 免疫腫瘍学のための組成物および方法
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
EP3523331A1 (en) 2016-10-07 2019-08-14 Novartis AG Chimeric antigen receptors for the treatment of cancer
EP4043485A1 (en) 2017-01-26 2022-08-17 Novartis AG Cd28 compositions and methods for chimeric antigen receptor therapy
MX2019011272A (es) * 2017-03-22 2019-10-24 Novartis Ag Composiciones y metodos para inmunooncologia.
BR112020007576A2 (pt) 2017-10-18 2020-09-24 Novartis Ag composições e métodos para degradação de proteína seletiva
AU2019284911A1 (en) 2018-06-13 2020-12-17 Novartis Ag BCMA chimeric antigen receptors and uses thereof
CN109517073A (zh) * 2018-11-30 2019-03-26 北京泽勤生物医药有限公司 一种靶向治疗肿瘤的融合肽及其应用
EP3896158A4 (en) * 2018-12-11 2022-11-02 Kyoto University METHODS OF INDUCING A DELETION IN GENOMIC DNA
WO2020206055A1 (en) * 2019-04-02 2020-10-08 Yale University Methods of treatment of diseases and disorders associated with increased tet level, increased h19 level, increased level of tgf signaling, or any combination thereof
AU2020264484A1 (en) 2019-05-01 2021-11-04 Adoc Ssf, Llc Compositions and methods for the treatment of cancer using a CDB engineered T cell therapy
AU2020343516A1 (en) 2019-09-06 2022-03-10 Crispr Therapeutics Ag Genetically engineered T cells having improved persistence in culture
CA3163104A1 (en) 2019-11-26 2021-06-03 Novartis Ag Chimeric antigen receptors and uses thereof
CN114945382A (zh) 2019-11-26 2022-08-26 诺华股份有限公司 Cd19和cd22嵌合抗原受体及其用途
WO2021127261A1 (en) * 2019-12-17 2021-06-24 The General Hospital Corporation Engineered immune cells with reduced toxicity and uses thereof
CN115427451A (zh) * 2020-02-14 2022-12-02 北京永泰瑞科生物科技有限公司 过表达从外部导入的细胞信号调节因子的免疫细胞及其用途
US20230355671A1 (en) * 2020-03-18 2023-11-09 The Board Of Trustees Of The Leland Stanford Junior University Upregulation of Cathelicidin Gene Expression as an Adjuvant to Other Treatments for Diseases
TW202216768A (zh) 2020-06-22 2022-05-01 美商恩格姆生物製藥公司 Lair-1結合劑及其使用方法
US20230302155A1 (en) 2020-08-21 2023-09-28 Novartis Ag Compositions and methods for in vivo generation of car expressing cells
US12152251B2 (en) 2020-08-25 2024-11-26 Kite Pharma, Inc. T cells with improved functionality
CN113045658B (zh) 2020-12-11 2021-12-24 广州百暨基因科技有限公司 抗cll1抗体及其应用
CN113234169B (zh) * 2020-12-11 2022-11-01 广州百暨基因科技有限公司 靶向cll1嵌合抗原受体及其应用
WO2023086882A1 (en) * 2021-11-11 2023-05-19 The Trustees Of The University Of Pennsylvania Compositions and methods comprising car t cells comprising prdm1 and/or nr4a3 knockout
KR102521500B1 (ko) * 2021-12-02 2023-04-14 한국화학연구원 증진된 효능을 갖는 면역세포
CN114350665A (zh) * 2022-01-19 2022-04-15 上海优替济生生物医药有限公司 IFN-γ抑制剂及其用途
CN114404592A (zh) * 2022-02-09 2022-04-29 复旦大学附属中山医院 Tet2作为靶标在治疗缺血性血管疾病中的应用
WO2024059834A2 (en) * 2022-09-15 2024-03-21 H. Lee Moffitt Cancer Center And Research Institute Inc. Downregulating inos to increase car-t killing
WO2025189025A2 (en) * 2024-03-07 2025-09-12 Biontech Us Inc. Methods and compositions for engineering t cells

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