JP2020513828A5 - - Google Patents

Download PDF

Info

Publication number
JP2020513828A5
JP2020513828A5 JP2019552085A JP2019552085A JP2020513828A5 JP 2020513828 A5 JP2020513828 A5 JP 2020513828A5 JP 2019552085 A JP2019552085 A JP 2019552085A JP 2019552085 A JP2019552085 A JP 2019552085A JP 2020513828 A5 JP2020513828 A5 JP 2020513828A5
Authority
JP
Japan
Prior art keywords
tet2
cancer
cell
genes
related gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019552085A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020513828A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/023785 external-priority patent/WO2018175733A1/en
Publication of JP2020513828A publication Critical patent/JP2020513828A/ja
Publication of JP2020513828A5 publication Critical patent/JP2020513828A5/ja
Priority to JP2023051134A priority Critical patent/JP2023082071A/ja
Pending legal-status Critical Current

Links

JP2019552085A 2017-03-22 2018-03-22 増強された有効性を有するバイオマーカー及びcar t細胞療法 Pending JP2020513828A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023051134A JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762474991P 2017-03-22 2017-03-22
US62/474,991 2017-03-22
US201862621356P 2018-01-24 2018-01-24
US62/621,356 2018-01-24
PCT/US2018/023785 WO2018175733A1 (en) 2017-03-22 2018-03-22 Biomarkers and car t cell therapies with enhanced efficacy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023051134A Division JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Publications (2)

Publication Number Publication Date
JP2020513828A JP2020513828A (ja) 2020-05-21
JP2020513828A5 true JP2020513828A5 (enExample) 2021-04-30

Family

ID=62104357

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019552085A Pending JP2020513828A (ja) 2017-03-22 2018-03-22 増強された有効性を有するバイオマーカー及びcar t細胞療法
JP2023051134A Pending JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023051134A Pending JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Country Status (12)

Country Link
US (1) US20200087376A1 (enExample)
EP (1) EP3600392A1 (enExample)
JP (2) JP2020513828A (enExample)
KR (1) KR20190127892A (enExample)
CN (1) CN110831619A (enExample)
AU (1) AU2018240295A1 (enExample)
BR (1) BR112019019426A2 (enExample)
CA (1) CA3057306A1 (enExample)
IL (1) IL269412A (enExample)
RU (1) RU2019133286A (enExample)
SG (1) SG11201908719QA (enExample)
WO (1) WO2018175733A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9273283B2 (en) * 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
SG11201505896YA (en) 2013-02-20 2015-09-29 Novartis Ag Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
ES2769574T3 (es) 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
WO2015090229A1 (en) 2013-12-20 2015-06-25 Novartis Ag Regulatable chimeric antigen receptor
EP3097117B1 (en) 2014-01-21 2023-10-04 Novartis Ag Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
JP6831777B2 (ja) 2014-07-21 2021-02-17 ノバルティス アーゲー Cd33キメラ抗原受容体を使用する癌の処置
AU2015292744C1 (en) 2014-07-21 2021-01-21 Novartis Ag Treatment of cancer using humanized anti-BCMA chimeric antigen receptor
WO2016014553A1 (en) 2014-07-21 2016-01-28 Novartis Ag Sortase synthesized chimeric antigen receptors
EP3712171A1 (en) 2014-08-19 2020-09-23 Novartis AG Treatment of cancer using a cd123 chimeric antigen receptor
US11459390B2 (en) 2015-01-16 2022-10-04 Novartis Ag Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
PL3280729T3 (pl) 2015-04-08 2022-08-22 Novartis Ag Terapie cd20, terapie cd22 i terapie skojarzone komórką eksprymującą chimeryczny receptor antygenowy (car) cd19
WO2016168595A1 (en) 2015-04-17 2016-10-20 Barrett David Maxwell Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
WO2016172583A1 (en) 2015-04-23 2016-10-27 Novartis Ag Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
US10829735B2 (en) 2015-07-21 2020-11-10 The Trustees Of The University Of Pennsylvania Methods for improving the efficacy and expansion of immune cells
US11667691B2 (en) 2015-08-07 2023-06-06 Novartis Ag Treatment of cancer using chimeric CD3 receptor proteins
WO2017040930A2 (en) 2015-09-03 2017-03-09 The Trustees Of The University Of Pennsylvania Biomarkers predictive of cytokine release syndrome
WO2017093969A1 (en) 2015-12-04 2017-06-08 Novartis Ag Compositions and methods for immunooncology
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
JP7467117B2 (ja) 2016-10-07 2024-04-15 ノバルティス アーゲー 癌の治療のためのキメラ抗原受容体
US11535662B2 (en) 2017-01-26 2022-12-27 Novartis Ag CD28 compositions and methods for chimeric antigen receptor therapy
KR20190130608A (ko) 2017-03-22 2019-11-22 노파르티스 아게 면역종양학을 위한 조성물 및 방법
SG11202003415XA (en) 2017-10-18 2020-05-28 Novartis Ag Compositions and methods for selective protein degradation
WO2019136432A1 (en) 2018-01-08 2019-07-11 Novartis Ag Immune-enhancing rnas for combination with chimeric antigen receptor therapy
IL279367B2 (en) 2018-06-13 2026-05-01 Novartis Ag BCMA chimeric antigen receptors and their uses
SI3844267T1 (sl) 2018-08-31 2025-10-30 Novartis Ag Postopki izdelave celic, ki izražajo receptorje himernega antigena
CN109517073A (zh) * 2018-11-30 2019-03-26 北京泽勤生物医药有限公司 一种靶向治疗肿瘤的融合肽及其应用
WO2020122104A1 (ja) * 2018-12-11 2020-06-18 国立大学法人京都大学 ゲノムdnaに欠失を誘導する方法
WO2020206055A1 (en) * 2019-04-02 2020-10-08 Yale University Methods of treatment of diseases and disorders associated with increased tet level, increased h19 level, increased level of tgf signaling, or any combination thereof
MX2021013218A (es) 2019-05-01 2021-12-10 Pact Pharma Inc Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2.
PH12022550548A1 (en) 2019-09-06 2023-11-20 Crispr Therapeutics Ag Genetically engineered t cells having improved persistence in culture
JP7805928B2 (ja) 2019-11-26 2026-01-26 ノバルティス アーゲー Cd19及びcd22キメラ抗原受容体及びその使用
WO2021108661A2 (en) 2019-11-26 2021-06-03 Novartis Ag Chimeric antigen receptors and uses thereof
EP4076476A4 (en) * 2019-12-17 2023-11-22 The General Hospital Corporation MODIFIED IMMUNE CELLS WITH REDUCED TOXICITY AND THEIR USES
US12685490B2 (en) 2020-01-28 2026-07-21 The Board Of Trustees Of The Leland Stanford Junior University Method of preventing or treating pancreatic dysfunction or diabetes by upregulating human cathelicidin LL-37 to inhibit islet amyloid polypeptide (IAPP) self-assembly
CN115427451B (zh) * 2020-02-14 2026-02-17 北京永泰瑞科生物科技有限公司 过表达从外部导入的细胞信号调节因子的免疫细胞及其用途
US20230355671A1 (en) * 2020-03-18 2023-11-09 The Board Of Trustees Of The Leland Stanford Junior University Upregulation of Cathelicidin Gene Expression as an Adjuvant to Other Treatments for Diseases
EP4168451A2 (en) 2020-06-22 2023-04-26 NGM Biopharmaceuticals, Inc. Lair-1-binding agents and methods of use thereof
WO2022040586A2 (en) 2020-08-21 2022-02-24 Novartis Ag Compositions and methods for in vivo generation of car expressing cells
EP4501951A3 (en) * 2020-08-25 2025-04-30 Kite Pharma, Inc. T cells with improved functionality
CN113234169B (zh) 2020-12-11 2022-11-01 广州百暨基因科技有限公司 靶向cll1嵌合抗原受体及其应用
CN113045658B (zh) 2020-12-11 2021-12-24 广州百暨基因科技有限公司 抗cll1抗体及其应用
US20240325535A1 (en) * 2021-11-11 2024-10-03 The Trustees Of The University Of Pennsylvania Compositions and methods comprising car t cells comprising prdm1 and/or nr4a3 knockout
KR102521500B1 (ko) * 2021-12-02 2023-04-14 한국화학연구원 증진된 효능을 갖는 면역세포
CN114350665A (zh) * 2022-01-19 2022-04-15 上海优替济生生物医药有限公司 IFN-γ抑制剂及其用途
CN114404592A (zh) * 2022-02-09 2022-04-29 复旦大学附属中山医院 Tet2作为靶标在治疗缺血性血管疾病中的应用
US20260083844A1 (en) * 2022-09-15 2026-03-26 H. Lee Moffitt Cancer Center And Research Institute Inc. Downregulating inos to increase car-t killing
WO2025189025A2 (en) * 2024-03-07 2025-09-12 Biontech Us Inc. Methods and compositions for engineering t cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2999070A1 (en) * 2015-09-17 2017-03-23 Novartis Ag Car t cell therapies with enhanced efficacy

Similar Documents

Publication Publication Date Title
RU2019133286A (ru) Биомаркеры и средства терапии на основе т-клеток с car с повышенной эффективностью
Larson et al. Recent advances and discoveries in the mechanisms and functions of CAR T cells
JP7303749B2 (ja) Tim-1を標的とするキメラ抗原受容体
JP2021534783A5 (enExample)
JP2023516008A5 (enExample)
IL295604A (en) Methods of making chimeric antigen receptor-expressing cells
IL295878A (en) Methods for producing cells expressing a chimeric antigen receptor
JP2018527008A5 (enExample)
JP2019532953A5 (enExample)
CN108276493B (zh) 一种嵌合抗原受体及其应用
JP2017513818A5 (enExample)
CN113164408B (zh) 肿瘤联合免疫治疗
JP2023529211A5 (enExample)
RU2018127657A (ru) Виды терапии на основе иммуноэффекторных клеток с улучшенной эффективностью
JP2017530694A5 (enExample)
US20220096544A1 (en) Chemokine expressing cell and use thereof
JP2017527271A5 (enExample)
CA3059444A1 (en) Chimeric antigen receptor t cells targeting the tumor microenvironment
JP2020506700A5 (enExample)
US20220152101A1 (en) Cellular immunotherapy combination
JP2016514462A5 (enExample)
JP2024528988A (ja) 改変タンパク質の選択的分解のための組成物および方法
JP2020510074A5 (enExample)
US20250145683A1 (en) Engineered immune cells with dominant signals
CN110468105A (zh) 表达il-18r结合蛋白的免疫效应细胞