JP2020513828A5 - - Google Patents

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Publication number
JP2020513828A5
JP2020513828A5 JP2019552085A JP2019552085A JP2020513828A5 JP 2020513828 A5 JP2020513828 A5 JP 2020513828A5 JP 2019552085 A JP2019552085 A JP 2019552085A JP 2019552085 A JP2019552085 A JP 2019552085A JP 2020513828 A5 JP2020513828 A5 JP 2020513828A5
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JP
Japan
Prior art keywords
tet2
cancer
cell
genes
related gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019552085A
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English (en)
Japanese (ja)
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JP2020513828A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/023785 external-priority patent/WO2018175733A1/en
Publication of JP2020513828A publication Critical patent/JP2020513828A/ja
Publication of JP2020513828A5 publication Critical patent/JP2020513828A5/ja
Priority to JP2023051134A priority Critical patent/JP2023082071A/ja
Pending legal-status Critical Current

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JP2019552085A 2017-03-22 2018-03-22 増強された有効性を有するバイオマーカー及びcar t細胞療法 Pending JP2020513828A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023051134A JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762474991P 2017-03-22 2017-03-22
US62/474,991 2017-03-22
US201862621356P 2018-01-24 2018-01-24
US62/621,356 2018-01-24
PCT/US2018/023785 WO2018175733A1 (en) 2017-03-22 2018-03-22 Biomarkers and car t cell therapies with enhanced efficacy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023051134A Division JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Publications (2)

Publication Number Publication Date
JP2020513828A JP2020513828A (ja) 2020-05-21
JP2020513828A5 true JP2020513828A5 (enExample) 2021-04-30

Family

ID=62104357

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019552085A Pending JP2020513828A (ja) 2017-03-22 2018-03-22 増強された有効性を有するバイオマーカー及びcar t細胞療法
JP2023051134A Pending JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023051134A Pending JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びcar t細胞療法

Country Status (12)

Country Link
US (1) US20200087376A1 (enExample)
EP (1) EP3600392A1 (enExample)
JP (2) JP2020513828A (enExample)
KR (1) KR20190127892A (enExample)
CN (1) CN110831619A (enExample)
AU (1) AU2018240295A1 (enExample)
BR (1) BR112019019426A2 (enExample)
CA (1) CA3057306A1 (enExample)
IL (1) IL269412A (enExample)
RU (1) RU2019133286A (enExample)
SG (1) SG11201908719QA (enExample)
WO (1) WO2018175733A1 (enExample)

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US9745368B2 (en) 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
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ES2963718T3 (es) 2014-01-21 2024-04-01 Novartis Ag Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras
US11542488B2 (en) 2014-07-21 2023-01-03 Novartis Ag Sortase synthesized chimeric antigen receptors
JP7054622B2 (ja) 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗bcmaキメラ抗原受容体を使用した癌の処置
EP3722316A1 (en) 2014-07-21 2020-10-14 Novartis AG Treatment of cancer using a cd33 chimeric antigen receptor
ES2791248T3 (es) 2014-08-19 2020-11-03 Novartis Ag Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer
US11459390B2 (en) 2015-01-16 2022-10-04 Novartis Ag Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
US11161907B2 (en) 2015-02-02 2021-11-02 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
JP6961490B2 (ja) 2015-04-08 2021-11-05 ノバルティス アーゲー Cd20療法、cd22療法、およびcd19キメラ抗原受容体(car)発現細胞との併用療法
WO2016168595A1 (en) 2015-04-17 2016-10-20 Barrett David Maxwell Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
US12128069B2 (en) 2015-04-23 2024-10-29 The Trustees Of The University Of Pennsylvania Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
AR105433A1 (es) 2015-07-21 2017-10-04 Novartis Ag Métodos para mejorar la eficacia y expansión de las células inmunes
EP3331913A1 (en) 2015-08-07 2018-06-13 Novartis AG Treatment of cancer using chimeric cd3 receptor proteins
WO2017040930A2 (en) 2015-09-03 2017-03-09 The Trustees Of The University Of Pennsylvania Biomarkers predictive of cytokine release syndrome
HK1257295A1 (zh) 2015-12-04 2019-10-18 Novartis Ag 用於免疫肿瘤学的组合物和方法
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
WO2018067992A1 (en) 2016-10-07 2018-04-12 Novartis Ag Chimeric antigen receptors for the treatment of cancer
US11535662B2 (en) 2017-01-26 2022-12-27 Novartis Ag CD28 compositions and methods for chimeric antigen receptor therapy
EP3601561A2 (en) * 2017-03-22 2020-02-05 Novartis AG Compositions and methods for immunooncology
KR20200086278A (ko) 2017-10-18 2020-07-16 노파르티스 아게 선택적 단백질 분해를 위한 조성물 및 방법
TWI890660B (zh) 2018-06-13 2025-07-21 瑞士商諾華公司 Bcma 嵌合抗原受體及其用途
CN109517073A (zh) * 2018-11-30 2019-03-26 北京泽勤生物医药有限公司 一种靶向治疗肿瘤的融合肽及其应用
EP3896158A4 (en) * 2018-12-11 2022-11-02 Kyoto University METHODS OF INDUCING A DELETION IN GENOMIC DNA
US20220160751A1 (en) * 2019-04-02 2022-05-26 Yale University Methods of treatment of diseases and disorders associated with increased tet level, increased h19 level, increased level of tgf signaling, or any combination thereof
CA3151385A1 (en) 2019-05-01 2020-11-05 Pact Pharma, Inc. Compositions and methods for the treatment of cancer using a tet2 engineered t cell therapy
US12344656B2 (en) 2019-09-06 2025-07-01 Crispr Therapeutics Ag Genetically engineered T cells having improved persistence in culture
AR120566A1 (es) 2019-11-26 2022-02-23 Novartis Ag Receptores de antígeno quiméricos y sus usos
BR112022009679A2 (pt) 2019-11-26 2022-08-09 Novartis Ag Receptores de antígeno quimérico cd19 e cd22 e usos dos mesmos
US20230036569A1 (en) * 2019-12-17 2023-02-02 The General Hospital Corporation Engineered immune cells with reduced toxicity and uses thereof
EP4105232A4 (en) * 2020-02-14 2023-10-11 Beijing Yongtai Ruike Biotechnology Company Ltd Immune cells overexpressing cell signaling regulatory factor introduced from outside and use thereof
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US12240899B2 (en) 2020-06-22 2025-03-04 Ngm Biopharmaceuticals, Inc. LAIR-1-binding agents and methods of use thereof
TW202227124A (zh) 2020-08-21 2022-07-16 瑞士商諾華公司 用於體內產生car表現細胞的組成物和方法
EP4501951A3 (en) * 2020-08-25 2025-04-30 Kite Pharma, Inc. T cells with improved functionality
CN113980134B (zh) 2020-12-11 2022-05-31 广州百暨基因科技有限公司 抗cll1抗体及其应用
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CN114350665A (zh) * 2022-01-19 2022-04-15 上海优替济生生物医药有限公司 IFN-γ抑制剂及其用途
CN114404592A (zh) * 2022-02-09 2022-04-29 复旦大学附属中山医院 Tet2作为靶标在治疗缺血性血管疾病中的应用
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