JP2024528988A5 - - Google Patents
Info
- Publication number
- JP2024528988A5 JP2024528988A5 JP2024506674A JP2024506674A JP2024528988A5 JP 2024528988 A5 JP2024528988 A5 JP 2024528988A5 JP 2024506674 A JP2024506674 A JP 2024506674A JP 2024506674 A JP2024506674 A JP 2024506674A JP 2024528988 A5 JP2024528988 A5 JP 2024528988A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- modified polypeptide
- cancer
- polypeptide according
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163230225P | 2021-08-06 | 2021-08-06 | |
| US63/230,225 | 2021-08-06 | ||
| PCT/US2022/074589 WO2023015283A1 (en) | 2021-08-06 | 2022-08-05 | Compositions and methods for selective degradation of engineered proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024528988A JP2024528988A (ja) | 2024-08-01 |
| JP2024528988A5 true JP2024528988A5 (enExample) | 2025-08-13 |
Family
ID=83692652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024506674A Pending JP2024528988A (ja) | 2021-08-06 | 2022-08-05 | 改変タンパク質の選択的分解のための組成物および方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20230095912A1 (enExample) |
| EP (1) | EP4380582A1 (enExample) |
| JP (1) | JP2024528988A (enExample) |
| KR (1) | KR20240043780A (enExample) |
| CN (1) | CN117794554A (enExample) |
| AR (1) | AR126718A1 (enExample) |
| AU (1) | AU2022324621A1 (enExample) |
| CA (1) | CA3223636A1 (enExample) |
| CL (1) | CL2024000305A1 (enExample) |
| CO (1) | CO2024001133A2 (enExample) |
| IL (1) | IL309653A (enExample) |
| MX (1) | MX2024000901A (enExample) |
| PE (1) | PE20252433A1 (enExample) |
| TW (1) | TW202321278A (enExample) |
| WO (1) | WO2023015283A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202304214D0 (en) * | 2023-03-23 | 2023-05-10 | Univ Oxford Innovation Ltd | System |
| KR20260005248A (ko) * | 2023-03-24 | 2026-01-09 | 주식회사 핀테라퓨틱스 | Gspt1 분해 화합물 및 분해 방법 |
| EP4694907A1 (en) * | 2023-06-30 | 2026-02-18 | Universität Heidelberg | Peptides as antagonists of ikaros zinc finger family (ikzf) proteins to activate the immune system against tumor cells |
| WO2025016359A1 (zh) * | 2023-07-14 | 2025-01-23 | 标新生物医药科技(上海)有限公司 | 戊二酰亚胺基异吲哚啉酮骨架的化合物 |
| WO2025110699A1 (ko) * | 2023-11-21 | 2025-05-30 | 주식회사 프로티어바이오텍 | 신규한 화합물 및 이의 용도 |
| WO2025199379A1 (en) | 2024-03-22 | 2025-09-25 | Bristol-Myers Squibb Company | Novel fak degrader compounds and uses thereof |
| CN119708220B (zh) * | 2024-12-23 | 2025-08-05 | 无锡傲锐东源生物科技有限公司 | 抗人yap1蛋白单克隆抗体及其杂交瘤细胞株和应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994A (en) | 1849-01-02 | Combined beading-tool and circular shears | ||
| US136A (en) | 1837-03-03 | Mode of molding candles | ||
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5665577A (en) | 1989-02-06 | 1997-09-09 | Dana-Farber Cancer Institute | Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US5948893A (en) | 1996-01-17 | 1999-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| ATE528406T1 (de) | 1999-04-29 | 2011-10-15 | Gbp Ip Llc | Verfahren und mittel zur herstellung von sicheren,rekombinanten lentivirusvektoren mit hohem titer |
| CN1352301A (zh) * | 2000-11-02 | 2002-06-05 | 上海博德基因开发有限公司 | 一种新的多肽——人二氢乳清酸酶9.46和编码这种多肽的多核苷酸 |
| GB201710620D0 (en) * | 2017-07-03 | 2017-08-16 | Glaxosmithkline Intellectual Property Ltd | Targeted protein degradation |
| EP4467143B1 (en) | 2017-07-10 | 2026-03-11 | Celgene Corporation | Method for preparing 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-l-yl)-3-fluorobenzonitrile |
| TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| AU2018351050B2 (en) * | 2017-10-18 | 2025-09-18 | Novartis Ag | Compositions and methods for selective protein degradation |
| US12049482B2 (en) * | 2017-10-31 | 2024-07-30 | The Brigham And Women's Hospital, Inc. | Molecular switch-mediated control of engineered cells |
| EP3959320A1 (en) * | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions and methods for selective protein degradation |
| CN110438112B (zh) * | 2019-08-16 | 2021-09-10 | 苏州科宁多元醇有限公司 | 一种d-阿洛酮糖-3-差向异构酶的突变体及其应用 |
-
2022
- 2022-08-05 CA CA3223636A patent/CA3223636A1/en active Pending
- 2022-08-05 PE PE2024000202A patent/PE20252433A1/es unknown
- 2022-08-05 KR KR1020247007065A patent/KR20240043780A/ko active Pending
- 2022-08-05 US US17/817,777 patent/US20230095912A1/en active Pending
- 2022-08-05 MX MX2024000901A patent/MX2024000901A/es unknown
- 2022-08-05 TW TW111129489A patent/TW202321278A/zh unknown
- 2022-08-05 EP EP22790152.7A patent/EP4380582A1/en active Pending
- 2022-08-05 AU AU2022324621A patent/AU2022324621A1/en active Pending
- 2022-08-05 AR ARP220102109A patent/AR126718A1/es unknown
- 2022-08-05 JP JP2024506674A patent/JP2024528988A/ja active Pending
- 2022-08-05 IL IL309653A patent/IL309653A/en unknown
- 2022-08-05 WO PCT/US2022/074589 patent/WO2023015283A1/en not_active Ceased
- 2022-08-05 CN CN202280054544.9A patent/CN117794554A/zh active Pending
-
2024
- 2024-01-31 CL CL2024000305A patent/CL2024000305A1/es unknown
- 2024-02-01 CO CONC2024/0001133A patent/CO2024001133A2/es unknown
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