JP2020513828A - 増強された有効性を有するバイオマーカー及びｃａｒ ｔ細胞療法 - Google Patents

増強された有効性を有するバイオマーカー及びｃａｒ ｔ細胞療法 Download PDF

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JP2020513828A
JP2020513828A JP2019552085A JP2019552085A JP2020513828A JP 2020513828 A JP2020513828 A JP 2020513828A JP 2019552085 A JP2019552085 A JP 2019552085A JP 2019552085 A JP2019552085 A JP 2019552085A JP 2020513828 A JP2020513828 A JP 2020513828A
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tet2
cell
gene
genes
car
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JP2020513828A5 (enExample
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ジョセフ・エイ・フライエッタ
ジャン・ジェイ・メレンホースト
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ノバルティス アーゲー
ノバルティス アーゲー
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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Publication of JP2020513828A publication Critical patent/JP2020513828A/ja
Publication of JP2020513828A5 publication Critical patent/JP2020513828A5/ja
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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JP2019552085A 2017-03-22 2018-03-22 増強された有効性を有するバイオマーカー及びｃａｒ ｔ細胞療法 Pending JP2020513828A (ja)

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JP2023051134A JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びｃａｒ ｔ細胞療法

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US201762474991P 2017-03-22 2017-03-22
US62/474,991 2017-03-22
US201862621356P 2018-01-24 2018-01-24
US62/621,356 2018-01-24
PCT/US2018/023785 WO2018175733A1 (en) 2017-03-22 2018-03-22 Biomarkers and car t cell therapies with enhanced efficacy

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JP2020513828A5 JP2020513828A5 (enExample) 2021-04-30

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JP2023051134A Pending JP2023082071A (ja) 2017-03-22 2023-03-28 増強された有効性を有するバイオマーカー及びｃａｒ ｔ細胞療法

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US (1) US20200087376A1 (enExample)
EP (1) EP3600392A1 (enExample)
JP (2) JP2020513828A (enExample)
KR (1) KR20190127892A (enExample)
CN (1) CN110831619A (enExample)
AU (1) AU2018240295A1 (enExample)
BR (1) BR112019019426A2 (enExample)
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PL3280729T3 (pl) 2015-04-08 2022-08-22 Novartis Ag Terapie cd20, terapie cd22 i terapie skojarzone komórką eksprymującą chimeryczny receptor antygenowy (car) cd19
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