JP2019532953A5 - - Google Patents

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Publication number
JP2019532953A5
JP2019532953A5 JP2019517396A JP2019517396A JP2019532953A5 JP 2019532953 A5 JP2019532953 A5 JP 2019532953A5 JP 2019517396 A JP2019517396 A JP 2019517396A JP 2019517396 A JP2019517396 A JP 2019517396A JP 2019532953 A5 JP2019532953 A5 JP 2019532953A5
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JP
Japan
Prior art keywords
seq
immune effector
amino acid
cancer
effector cells
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Pending
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JP2019517396A
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English (en)
Japanese (ja)
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JP2019532953A (ja
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Publication date
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Priority claimed from PCT/CN2017/104422 external-priority patent/WO2018059549A1/en
Publication of JP2019532953A publication Critical patent/JP2019532953A/ja
Publication of JP2019532953A5 publication Critical patent/JP2019532953A5/ja
Pending legal-status Critical Current

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JP2019517396A 2016-09-30 2017-09-29 増強された有効性を有する免疫エフェクター細胞治療 Pending JP2019532953A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016101213 2016-09-30
CNPCT/CN2016/101213 2016-09-30
PCT/CN2017/104422 WO2018059549A1 (en) 2016-09-30 2017-09-29 Immune effector cell therapies with enhanced efficacy

Publications (2)

Publication Number Publication Date
JP2019532953A JP2019532953A (ja) 2019-11-14
JP2019532953A5 true JP2019532953A5 (enExample) 2021-08-12

Family

ID=61763296

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019517396A Pending JP2019532953A (ja) 2016-09-30 2017-09-29 増強された有効性を有する免疫エフェクター細胞治療

Country Status (5)

Country Link
US (1) US20190298715A1 (enExample)
EP (1) EP3523290A4 (enExample)
JP (1) JP2019532953A (enExample)
CN (1) CN110582488A (enExample)
WO (1) WO2018059549A1 (enExample)

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UY35340A (es) 2013-02-20 2014-09-30 Novartis Ag Marcaje efectivo de leucemia humana usando células diseñadas con un receptor quimérico de antígeno anti-cd123
US9745368B2 (en) 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
TWI654206B (zh) 2013-03-16 2019-03-21 諾華公司 使用人類化抗-cd19嵌合抗原受體治療癌症
US10287354B2 (en) 2013-12-20 2019-05-14 Novartis Ag Regulatable chimeric antigen receptor
EP4303229A3 (en) 2014-01-21 2024-04-17 Novartis AG Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
MX390943B (es) 2014-07-21 2025-03-21 Novartis Ag Receptores de antígeno quimérico cd33 y usos de los mismos.
MY181834A (en) 2014-07-21 2021-01-08 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
WO2016014553A1 (en) 2014-07-21 2016-01-28 Novartis Ag Sortase synthesized chimeric antigen receptors
MY189028A (en) 2014-08-19 2022-01-20 Novartis Ag Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
CN114107424A (zh) 2014-10-08 2022-03-01 诺华股份有限公司 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途
WO2016115482A1 (en) 2015-01-16 2016-07-21 Novartis Pharma Ag Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
HUE059218T2 (hu) 2015-04-08 2022-11-28 Novartis Ag CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel
SG11201708516YA (en) 2015-04-17 2017-11-29 David Maxwell Barrett Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
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AU2016382512A1 (en) * 2015-12-30 2018-07-12 Novartis Ag Immune effector cell therapies with enhanced efficacy
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MY200337A (en) 2016-10-07 2023-12-20 Novartis Ag Nucleic acid molecules encoding chimeric antigen receptors comprising a cd20 binding domain
US11535662B2 (en) 2017-01-26 2022-12-27 Novartis Ag CD28 compositions and methods for chimeric antigen receptor therapy
JP2020513832A (ja) 2017-03-22 2020-05-21 ノバルティス アーゲー 免疫腫瘍学のための組成物および方法
UY37774A (es) * 2017-06-19 2019-01-31 Novartis Ag Compuestos 5-cianoindol sustituidos y usos de los mismos
SG11202003415XA (en) 2017-10-18 2020-05-28 Novartis Ag Compositions and methods for selective protein degradation
US20220307087A1 (en) * 2018-04-25 2022-09-29 The Methodist Hospital System Cancer neoantigens and their utilities in cancer vaccines and tcr-based cancer immunotherapy
MY208825A (en) 2018-06-13 2025-05-30 Novartis Ag Bcma chimeric antigen receptors and uses thereof
PH12022551290A1 (en) 2019-11-26 2023-11-29 Novartis Ag Cd19 and cd22 chimeric antigen receptors and uses thereof
AU2020393912B2 (en) 2019-11-26 2025-11-20 Novartis Ag Chimeric antigen receptors binding BCMA and CD19 and uses thereof
AU2021225978A1 (en) * 2020-02-27 2022-09-08 Legend Biotech Ireland Limited Antibodies and chimeric antigen receptors targeting glypican-3 (GPC3) and methods of use thereof
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CN114426952A (zh) * 2020-10-29 2022-05-03 中国科学技术大学 用于白血病的car t细胞疗法的t细胞增效剂及获得增效t细胞的方法
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CN113462723B (zh) * 2021-07-05 2023-07-11 北京中医药大学 表达CAR和shRNA的逆转录病毒载体及其应用
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