ES2970269T3 - Linfocitos citolíticos naturales modificados y líneas de linfocitos citolíticos naturales que tienen citotoxicidad aumentada - Google Patents

Linfocitos citolíticos naturales modificados y líneas de linfocitos citolíticos naturales que tienen citotoxicidad aumentada Download PDF

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Publication number
ES2970269T3
ES2970269T3 ES20213303T ES20213303T ES2970269T3 ES 2970269 T3 ES2970269 T3 ES 2970269T3 ES 20213303 T ES20213303 T ES 20213303T ES 20213303 T ES20213303 T ES 20213303T ES 2970269 T3 ES2970269 T3 ES 2970269T3
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natural killer
cell lines
increased cytotoxicity
killer cells
modified
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Michael Eamon Peter O'dwyer
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Onk Therapeutics Ltd
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Onk Therapeutics Ltd
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Priority claimed from GBGB1610164.4A external-priority patent/GB201610164D0/en
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ES20213303T 2015-07-29 2016-07-28 Linfocitos citolíticos naturales modificados y líneas de linfocitos citolíticos naturales que tienen citotoxicidad aumentada Active ES2970269T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15178899 2015-07-29
GBGB1603655.0A GB201603655D0 (en) 2016-03-02 2016-03-02 Modified natural killer cells and natural killer cell lines having increased cytotoxicity
GB201605457 2016-03-31
GBGB1610164.4A GB201610164D0 (en) 2016-06-10 2016-06-10 Modified natural killer cells and natural killer cell lines having increased cytoxicity

Publications (1)

Publication Number Publication Date
ES2970269T3 true ES2970269T3 (es) 2024-05-27

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ES18187137T Active ES2890859T3 (es) 2015-07-29 2016-07-28 Células asesinas naturales modificadas y líneas de células asesinas naturales que tienen citotoxicidad aumentada
ES16750677T Active ES2701338T3 (es) 2015-07-29 2016-07-28 Células asesinas naturales modificadas y líneas de células asesinas naturales que tienen mayor citotoxicidad
ES20213303T Active ES2970269T3 (es) 2015-07-29 2016-07-28 Linfocitos citolíticos naturales modificados y líneas de linfocitos citolíticos naturales que tienen citotoxicidad aumentada
ES18194107T Active ES2876938T3 (es) 2015-07-29 2016-07-28 Células asesinas naturales modificadas y líneas de células asesinas naturales que tienen mayor citotoxicidad
ES21152473T Active ES2939084T3 (es) 2015-07-29 2016-07-28 Células asesinas naturales y líneas de células asesinas naturales modificadas que tienen citotoxicidad aumentada

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ES18187137T Active ES2890859T3 (es) 2015-07-29 2016-07-28 Células asesinas naturales modificadas y líneas de células asesinas naturales que tienen citotoxicidad aumentada
ES16750677T Active ES2701338T3 (es) 2015-07-29 2016-07-28 Células asesinas naturales modificadas y líneas de células asesinas naturales que tienen mayor citotoxicidad

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ES18194107T Active ES2876938T3 (es) 2015-07-29 2016-07-28 Células asesinas naturales modificadas y líneas de células asesinas naturales que tienen mayor citotoxicidad
ES21152473T Active ES2939084T3 (es) 2015-07-29 2016-07-28 Células asesinas naturales y líneas de células asesinas naturales modificadas que tienen citotoxicidad aumentada

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US (3) US10034925B2 (es)
EP (6) EP3828266B1 (es)
JP (3) JP6974681B2 (es)
KR (1) KR20180028530A (es)
CN (3) CN116064401A (es)
AU (2) AU2016300128B2 (es)
BR (1) BR112018001660A2 (es)
CA (2) CA2993796C (es)
DK (3) DK3421590T3 (es)
ES (5) ES2890859T3 (es)
HK (1) HK1252582B (es)
MX (2) MX2018001074A (es)
WO (1) WO2017017184A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10906951B2 (en) 2015-07-29 2021-02-02 Onk Therapeutics Limited Modified natural killer cells and natural killer cell lines having increased cytotoxicity
ES2890859T3 (es) 2015-07-29 2022-01-24 Onk Therapeutics Ltd Células asesinas naturales modificadas y líneas de células asesinas naturales que tienen citotoxicidad aumentada
WO2017180587A2 (en) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
CN117305250A (zh) 2016-12-09 2023-12-29 昂克医疗有限公司 工程化天然杀伤细胞及其用途
KR102528384B1 (ko) * 2017-01-06 2023-05-02 이뮤너티바이오, 인크. 감소된 cd96/tigit 발현을 갖는 유전자 변형된 nk-92 세포
CA3052473A1 (en) * 2017-02-09 2018-08-16 Indapta Therapeutics, Inc. Engineered natural killer (nk) cells and compositions and methods thereof
DE102017002645A1 (de) * 2017-03-17 2018-09-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Bestrahlung von Säugetierzellen mit Elektronenstrahlen und/oder Röntgenstrahlen
WO2019016360A1 (en) * 2017-07-21 2019-01-24 Cellectis MODIFIED IMMUNE CELLS RESISTANT TO TUMOR MICRO-ENVIRONMENT
EP3638260A1 (en) 2017-07-21 2020-04-22 Cellectis Engineered immune cells resistant to tumor microoenvironment
WO2019101998A1 (en) 2017-11-24 2019-05-31 Onkimmune Limited Modified natural killer cells and natural killer cell lines targetting tumour cells
SG11202011313UA (en) * 2018-05-16 2020-12-30 Res Inst Nationwide Childrens Hospital Generation of knock-out primary and expanded human nk cells using cas9 ribonucleoproteins
WO2019232631A1 (en) * 2018-06-06 2019-12-12 Stemcell Technologies Canada Inc. Kits, compositions and methods for myeloid-derived suppressor cell enrichment
CN108743595B (zh) * 2018-06-08 2020-11-27 厦门诺康得生物科技有限公司 一种nk细胞免疫检查点抑制剂及其制备方法
AU2020221409A1 (en) * 2019-02-15 2021-09-02 Editas Medicine, Inc. Modified natural killer (NK) cells for immunotherapy
CN109908155A (zh) * 2019-03-11 2019-06-21 上海中医药大学 丹参酮ⅱa的药物用途
WO2020189942A1 (ko) * 2019-03-15 2020-09-24 한국과학기술연구원 암 상살 능력이 향상된 면역세포
KR102292657B1 (ko) 2019-03-15 2021-08-24 한국과학기술연구원 암 상살 능력이 향상된 면역세포
EP3712257A1 (en) 2019-03-21 2020-09-23 ONK Therapeutics Limited Modified natural killer cells with increased resistance to cell death
EP3942022A1 (en) * 2019-03-21 2022-01-26 ONK Therapeutics Limited Modified immune effector cells with increased resistance to cell death
RU2731293C1 (ru) 2019-04-12 2020-09-01 Игорь Петрович Белецкий Способ получения генно-модифицированных линий клеток натуральных киллеров с нокаутированным геном PD-1 и повышенной экспрессией белков семейства Фактора Некроза Опухолей для иммунотерапии онкологических заболеваний
CN109970869A (zh) * 2019-04-12 2019-07-05 南京卡提医学科技有限公司 一种靶向人trail死亡受体的嵌合受体配体及其应用
EP3789485A1 (en) 2019-09-06 2021-03-10 ONK Therapeutics Limited Cellular therapies for cancer
CA3153197A1 (en) 2019-10-03 2021-04-08 Ryan T. Gill Crispr systems with engineered dual guide nucleic acids
CN111849896B (zh) * 2020-07-31 2022-07-01 广东昭泰体内生物医药科技有限公司 一种car-nk细胞培养基及其应用
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
JP2024500847A (ja) 2020-12-18 2024-01-10 センチュリー セラピューティクス,インコーポレイテッド 適合可能な受容体特異性を有するキメラ抗原受容体システム
WO2022256448A2 (en) 2021-06-01 2022-12-08 Artisan Development Labs, Inc. Compositions and methods for targeting, editing, or modifying genes
CA3223311A1 (en) 2021-06-18 2022-12-22 Andrea BARGHETTI Compositions and methods for targeting, editing or modifying human genes
WO2022263682A1 (en) 2021-06-18 2022-12-22 Onk Therapeutics Limited Double knockout natural killer cells
CN113684180B (zh) * 2021-08-31 2023-05-26 山东大学第二医院 一种提高骨髓瘤杀伤活性的nk细胞制备方法
WO2023167882A1 (en) 2022-03-01 2023-09-07 Artisan Development Labs, Inc. Composition and methods for transgene insertion
CN114796483B (zh) * 2022-06-28 2022-11-08 北京大学 活化t细胞与阻断性抗体联合制备抗肿瘤药物的用途及抗肿瘤药物
EP4353741A1 (en) 2022-10-14 2024-04-17 ONK Therapeutics Limited Double knockout natural killer cells
WO2024100203A1 (en) 2022-11-10 2024-05-16 Onk Therapeutics Limited Combined therapies using immunomodulating drugs
CN116590237B (zh) * 2023-05-29 2023-10-31 上海贝斯昂科生物科技有限公司 一种遗传修饰的自然杀伤细胞及其制备和用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7238360B2 (en) 2000-06-30 2007-07-03 Unversity Of Louisville Research Foundation, Inc. Alteration of cell membrane with B7
CA2388441A1 (en) 2002-06-10 2003-12-10 Wei-Ping Min Immunomodulation using rna interference
JP2008505071A (ja) * 2004-07-02 2008-02-21 アヴァリス・アクチエボラーグ 細胞を遺伝学的に活性化する方法、および、該細胞の使用
ATE443084T1 (de) * 2004-07-10 2009-10-15 Fox Chase Cancer Ct Genetisch modifizierte, menschliche, natürliche killerzellenlinien:
EP1621550A1 (en) 2004-07-29 2006-02-01 Dompé S.P.A. Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
GB0724532D0 (en) * 2007-12-17 2008-01-30 Nat Univ Ireland Trail variants for treating cancer
US9624469B2 (en) 2010-07-22 2017-04-18 Cellect Biotherapeutics Ltd. Regulatory immune cells with enhanced targeted cell death effect
AU2013329186B2 (en) * 2012-10-10 2019-02-14 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
WO2014134351A2 (en) * 2013-02-27 2014-09-04 The Broad Institute, Inc. T cell balance gene expression, compositions of matters and methods of use thereof
JP6395323B2 (ja) 2013-07-25 2018-09-26 株式会社ブリヂストン 防振装置
ES2741308T3 (es) * 2013-10-15 2020-02-10 Scripps Research Inst Interruptores de células T con receptores de antígenos quiméricos y usos de los mismos
WO2015142675A2 (en) * 2014-03-15 2015-09-24 Novartis Ag Treatment of cancer using chimeric antigen receptor
DK3129470T3 (da) 2014-04-07 2021-07-05 Novartis Ag Behandling af cancer ved anvendelse af anti-CD19-kimær antigenreceptor
JP2017513485A (ja) 2014-04-18 2017-06-01 エディタス・メディシン,インコーポレイテッド がん免疫療法のためのcrispr−cas関連方法、組成物および構成要素
AU2015317608B2 (en) * 2014-09-17 2021-03-11 Novartis Ag Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
CN115537396A (zh) * 2015-03-27 2022-12-30 哈佛学院校长同事会 经过修饰的t细胞及其制备和使用方法
EP4043556B1 (en) * 2015-06-30 2024-02-07 Cellectis Methods for improving functionality in nk cell by gene inactivation using specific endonuclease
WO2017015427A1 (en) * 2015-07-21 2017-01-26 Novartis Ag Methods for improving the efficacy and expansion of immune cells
ES2890859T3 (es) * 2015-07-29 2022-01-24 Onk Therapeutics Ltd Células asesinas naturales modificadas y líneas de células asesinas naturales que tienen citotoxicidad aumentada

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