DK3280423T3 - Synergistisk glycocalyx behandlingssammensætninger og fremgangsmåder - Google Patents

Synergistisk glycocalyx behandlingssammensætninger og fremgangsmåder Download PDF

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Publication number
DK3280423T3
DK3280423T3 DK16777402.5T DK16777402T DK3280423T3 DK 3280423 T3 DK3280423 T3 DK 3280423T3 DK 16777402 T DK16777402 T DK 16777402T DK 3280423 T3 DK3280423 T3 DK 3280423T3
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Denmark
Prior art keywords
glycocalyx
synergistic
methods
treatment compositions
compositions
Prior art date
Application number
DK16777402.5T
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English (en)
Inventor
Robert Maxfield Long
Hans Vink
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Microvascular Health Solutions Llc
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Publication of DK3280423T3 publication Critical patent/DK3280423T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01006—Catalase (1.11.1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK16777402.5T 2015-04-08 2016-04-08 Synergistisk glycocalyx behandlingssammensætninger og fremgangsmåder DK3280423T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562144484P 2015-04-08 2015-04-08
PCT/US2016/026739 WO2016164787A2 (en) 2015-04-08 2016-04-08 Synergistic glycocalyx treatment compositions and methods

Publications (1)

Publication Number Publication Date
DK3280423T3 true DK3280423T3 (da) 2023-09-04

Family

ID=57072731

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16777402.5T DK3280423T3 (da) 2015-04-08 2016-04-08 Synergistisk glycocalyx behandlingssammensætninger og fremgangsmåder

Country Status (14)

Country Link
US (2) US9943572B2 (da)
EP (2) EP4275704A3 (da)
JP (1) JP6518796B2 (da)
KR (1) KR101972691B1 (da)
CN (1) CN107771080B (da)
AU (1) AU2016245994A1 (da)
BR (1) BR112017021559A2 (da)
CA (1) CA3020277A1 (da)
DK (1) DK3280423T3 (da)
ES (1) ES2954984T3 (da)
HR (1) HRP20231090T1 (da)
MX (1) MX2017012967A (da)
PL (1) PL3280423T3 (da)
WO (1) WO2016164787A2 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10449209B2 (en) 2015-04-29 2019-10-22 Arterez, Llc Methods and compositions for reversing disruption of the glycocalyx, inflammation, and oxidative damage
WO2018208846A1 (en) * 2017-05-08 2018-11-15 Microvascular Health Solutions, LLC Compositions, systems, and methods for assessing and improving vascular health and treatments involving the same
CN111836833B (zh) * 2017-12-14 2023-01-31 卡尔罗伊健康科学公司 通过硫酸化多糖稳定并逆转动脉粥样硬化病变的方法
WO2022182968A1 (en) * 2021-02-25 2022-09-01 Calroy Health Sciences, Llc Synergistic compositions and methods to increase vascular nitric oxide to treat endothelial dysfunction and related conditions
CN113476461A (zh) * 2021-08-23 2021-10-08 苏州大学 一种提高抑炎型巨噬细胞趋化的药物及其应用
WO2023023994A1 (zh) * 2021-08-25 2023-03-02 苏州大学 一种提高抑炎型巨噬细胞趋化的药物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070141181A1 (en) * 1998-02-13 2007-06-21 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US7214666B1 (en) * 1999-11-02 2007-05-08 Shawn Paul Madere Composition of orally administered nutritional supplements to repair articular cartilage
US6797705B2 (en) 2002-12-16 2004-09-28 Endomatrix, Inc. Rhamnan sulphate composition for treatment of endothelial dysfunction
ES2386231T3 (es) 2007-11-30 2012-08-14 Universiteit Maastricht Herramienta de diagnóstico y terapéuticas para enfermedades que alteran la función vascular
CN101632686A (zh) * 2008-04-04 2010-01-27 马斯特里赫特大学 糖胺聚糖用于修复糖萼的用途
EP2323638B1 (en) * 2008-07-18 2014-05-07 Hill's Pet Nutrition, Inc. Compositions and methods for treating osteoarthritis
JP5819189B2 (ja) * 2009-03-25 2015-11-18 国立大学法人鳥取大学 軟骨生成促進剤および軟骨損傷由来疾病の予防治療剤
CA3129790A1 (en) * 2010-04-22 2011-10-22 Skinergistics Clinical Skin Solutions Inc. Seaweed-derived cosmetic compositions
KR20140053881A (ko) * 2011-04-19 2014-05-08 릭스하스피탈렛 모세관 누출의 예방 및 치료를 위한 수술 동안 투여되는 프로스타시클린 및 그 유사체
US20130273096A1 (en) * 2011-10-05 2013-10-17 Bruce A. Daniels Therapeutic Sulfated Polysaccharides, Compositions Thereof, and Methods for Treating Patients

Also Published As

Publication number Publication date
KR101972691B1 (ko) 2019-04-25
WO2016164787A3 (en) 2016-11-10
EP3280423A2 (en) 2018-02-14
EP4275704A2 (en) 2023-11-15
BR112017021559A2 (pt) 2018-07-03
CN107771080B (zh) 2021-12-14
CA3020277A1 (en) 2016-10-13
ES2954984T3 (es) 2023-11-28
US9943572B2 (en) 2018-04-17
WO2016164787A2 (en) 2016-10-13
JP6518796B2 (ja) 2019-05-22
CN107771080A (zh) 2018-03-06
EP3280423A4 (en) 2018-11-21
MX2017012967A (es) 2018-06-06
US20180078618A1 (en) 2018-03-22
EP4275704A3 (en) 2023-12-27
US20160296603A1 (en) 2016-10-13
EP3280423B1 (en) 2023-06-07
KR20170132886A (ko) 2017-12-04
AU2016245994A1 (en) 2017-11-30
PL3280423T3 (pl) 2023-12-27
JP2018510906A (ja) 2018-04-19
HRP20231090T1 (hr) 2024-01-05

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