DK3521289T3 - Mnk-inhibitorer og fremgangsmåder forbundet dermed - Google Patents
Mnk-inhibitorer og fremgangsmåder forbundet dermed Download PDFInfo
- Publication number
- DK3521289T3 DK3521289T3 DK19158973.8T DK19158973T DK3521289T3 DK 3521289 T3 DK3521289 T3 DK 3521289T3 DK 19158973 T DK19158973 T DK 19158973T DK 3521289 T3 DK3521289 T3 DK 3521289T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods related
- mnk inhibitors
- mnk
- inhibitors
- methods
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462017112P | 2014-06-25 | 2014-06-25 | |
EP15742147.0A EP3160966B1 (en) | 2014-06-25 | 2015-06-24 | Mnk inhibitors and methods related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3521289T3 true DK3521289T3 (da) | 2024-01-15 |
Family
ID=53724447
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK19158973.8T DK3521289T3 (da) | 2014-06-25 | 2015-06-24 | Mnk-inhibitorer og fremgangsmåder forbundet dermed |
DK15742147.0T DK3160966T3 (da) | 2014-06-25 | 2015-06-24 | Mnk-inhibitorer og fremgangsmåder forbundet dermed |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15742147.0T DK3160966T3 (da) | 2014-06-25 | 2015-06-24 | Mnk-inhibitorer og fremgangsmåder forbundet dermed |
Country Status (24)
Country | Link |
---|---|
US (6) | US9382248B2 (da) |
EP (2) | EP3521289B1 (da) |
JP (2) | JP6615797B2 (da) |
KR (1) | KR102460389B1 (da) |
CN (2) | CN106795162B (da) |
AU (1) | AU2015279984B2 (da) |
BR (1) | BR112016029916B1 (da) |
CA (1) | CA2953365C (da) |
CL (1) | CL2016003293A1 (da) |
CO (1) | CO2017000399A2 (da) |
DK (2) | DK3521289T3 (da) |
EA (1) | EA033920B1 (da) |
ES (2) | ES2728201T3 (da) |
FI (1) | FI3521289T3 (da) |
IL (1) | IL249557B (da) |
MX (1) | MX2016017030A (da) |
MY (1) | MY189363A (da) |
NZ (1) | NZ728007A (da) |
PE (1) | PE20170321A1 (da) |
PH (1) | PH12016502504A1 (da) |
SG (2) | SG10201811384TA (da) |
TW (1) | TWI713455B (da) |
WO (1) | WO2015200481A1 (da) |
ZA (1) | ZA201700241B (da) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | MnK抑制劑及其相關方法 |
DK3285809T3 (da) * | 2015-04-20 | 2019-11-18 | Effector Therapeutics Inc | Inhibitorer af immunkontrolpunktsmodulatorer til anvendelse i behandling af kræft og infektioner. |
EA201891049A1 (ru) | 2015-10-29 | 2018-10-31 | Эффектор Терапьютикс, Инк. | Изоиндолиновые, азаизоиндолиновые, дигидроинденоновые и дигидроазаинденоновые ингибиторы mnk1 и mnk2 |
JP6888006B2 (ja) | 2015-10-29 | 2021-06-16 | イーフェクター セラピューティクス, インコーポレイテッド | Mnk1およびmnk2を阻害するピロロ−、ピラゾロ−、イミダゾ−ピリミジンおよびピリジン化合物 |
WO2017087808A1 (en) | 2015-11-20 | 2017-05-26 | Effector Therapeutics, Inc. | Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers |
US20170191136A1 (en) * | 2015-12-31 | 2017-07-06 | Effector Therapeutics, Inc. | Mnk biomarkers and uses thereof |
US11261188B2 (en) | 2016-11-28 | 2022-03-01 | Praxis Precision Medicines, Inc. | Fused heteroaryl compounds, and methods thereof for treating diseases, disorders, and conditions relating to aberrant function of a sodium channel |
JP7105797B2 (ja) | 2016-11-28 | 2022-07-25 | プラクシス プレシジョン メディシンズ, インコーポレイテッド | 化合物及びその使用方法 |
WO2018134335A1 (en) * | 2017-01-20 | 2018-07-26 | Bayer Pharma Aktiengesellschaft | Substituted imidazopyridinpyrimidines |
TW201831479A (zh) * | 2017-01-20 | 2018-09-01 | 德商拜耳製藥公司 | 經取代二氫咪唑并吡啶二酮 |
WO2018148745A1 (en) * | 2017-02-13 | 2018-08-16 | Praxis Precision Medicines , Inc. | Compounds and their methods of use |
MX2019009653A (es) * | 2017-02-14 | 2019-12-19 | Effector Therapeutics Inc | Inhibidores de mnk sustituidos con piperidina y metodos relacionados con los mismos. |
WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
US10780119B2 (en) | 2017-05-24 | 2020-09-22 | Effector Therapeutics Inc. | Methods and compositions for cellular immunotherapy |
CN109020957B (zh) * | 2017-06-12 | 2023-01-13 | 南京天印健华医药科技有限公司 | 作为mnk抑制剂的杂环化合物 |
WO2019035951A1 (en) | 2017-08-15 | 2019-02-21 | Praxis Precision Medicines, Inc. | COMPOUNDS AND THEIR METHODS OF USE |
AU2018352695A1 (en) | 2017-10-19 | 2020-05-28 | Effector Therapeutics, Inc. | Benzimidazole-indole inhibitors of Mnk1 and Mnk2 |
AU2019278814A1 (en) | 2018-05-30 | 2020-12-17 | Praxis Precision Medicines, Inc. | Ion channel modulators |
EP3870178A4 (en) * | 2018-10-24 | 2022-08-03 | Effector Therapeutics Inc. | CRYSTALLINE FORMS OF MNK INHIBITORS |
WO2020108619A1 (zh) * | 2018-11-30 | 2020-06-04 | 上海迪诺医药科技有限公司 | Mnk抑制剂 |
CN111484494B (zh) * | 2019-01-29 | 2022-09-13 | 诺沃斯达药业(上海)有限公司 | 抑制mnk1和mnk2的多环化合物 |
US20220226321A1 (en) * | 2019-05-23 | 2022-07-21 | Board Of Regents, The University Of Texas System | Inhibitor of mnk for the treatment of neuropathic pain |
US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
JP2021008453A (ja) | 2019-07-02 | 2021-01-28 | エフェクター・セラピューティクス,インコーポレーテッド | 翻訳阻害剤およびその使用 |
TWI748541B (zh) | 2019-07-02 | 2021-12-01 | 美商eFFECTOR醫療公司 | eIF4E抑制性化合物與方法 |
EP3997089A4 (en) * | 2019-07-21 | 2023-08-16 | University Of Virginia Patent Foundation | CYSTEINE BINDING COMPOSITIONS AND METHODS OF USE THEREOF |
WO2021098691A1 (zh) * | 2019-11-18 | 2021-05-27 | 南京明德新药研发有限公司 | 作为mnk抑制剂的吡咯并三嗪类化合物 |
US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
MX2022016516A (es) * | 2020-06-30 | 2023-03-28 | 4E Therapeutics Inc | Piridina-1,5-dionas que exhiben inhibición de proteínas cinasas activadas por mitogenos que interaccionan con cinasas activadas (mnk) y su método de uso. |
US20240092799A1 (en) * | 2020-08-20 | 2024-03-21 | Hepagene Therapeutics (HK) Limited | Mnk inhibitors |
US11925642B2 (en) | 2020-10-08 | 2024-03-12 | Board Of Regents, The University Of Texas System | Regulation of eIF4E activity for migraine therapy |
CN117355528B (zh) * | 2021-05-08 | 2024-06-21 | 成都嘉葆药银医药科技有限公司 | 吡咯并三嗪类化合物的盐型、其晶型及其制备方法 |
KR20240027769A (ko) * | 2021-06-30 | 2024-03-04 | 4이 테라퓨틱스, 인크. | Mnk 억제를 나타내는 스피로사이클릭 피리딘-1,5-디온 및 이의 사용 방법 |
IL310590A (en) * | 2021-08-05 | 2024-04-01 | 4E Therapeutics Inc | Methods of treating migraine with MNK inhibitors |
CN114736205B (zh) * | 2022-03-31 | 2023-03-03 | 武汉九州钰民医药科技有限公司 | 化合物Tomivosertib的制备方法 |
CN114671869B (zh) * | 2022-03-31 | 2023-06-30 | 武汉九州钰民医药科技有限公司 | 化合物Tomivosertib的合成方法 |
CN114853756B (zh) * | 2022-03-31 | 2023-03-28 | 武汉九州钰民医药科技有限公司 | 化合物Tomivosertib的制备工艺 |
CN116425750A (zh) * | 2023-02-10 | 2023-07-14 | 诺沃斯达药业(上海)有限公司 | 一种mnk抑制剂化合物的盐、晶体及其制备方法 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5491144A (en) | 1991-05-30 | 1996-02-13 | Ciba-Geigy Corporation | Substituted diaminophthalimides and analogues |
US9357797B2 (en) * | 1999-11-06 | 2016-06-07 | Janmarie Hornack | Dietary supplement containing alkaline electrolyte buffers |
EP1401449B1 (en) * | 2001-06-05 | 2007-04-25 | Lilly Icos LLC | Tetracyclic compounds as pde5-inhibitors |
TWI301760B (en) | 2004-02-27 | 2008-10-11 | Merz Pharma Gmbh & Co Kgaa | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors |
US7488745B2 (en) | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
WO2007021309A1 (en) | 2005-08-12 | 2007-02-22 | Astrazeneca Ab | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
BRPI0713328A2 (pt) * | 2006-06-22 | 2012-10-30 | Biovitrum Ab | derivados de piridina e pirazina como inibidores de cinase mnk |
EP1889847A1 (en) * | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
EP2727909A1 (en) | 2007-03-16 | 2014-05-07 | The Scripps Research Institute | Inhibitors of focal adhesion kinase |
GB0706072D0 (en) | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
JP2009173629A (ja) | 2007-12-21 | 2009-08-06 | Banyu Pharmaceut Co Ltd | Rsk1阻害作用を有する新規スピロインダン誘導体 |
WO2009112445A1 (en) | 2008-03-10 | 2009-09-17 | Novartis Ag | Method of increasing cellular phosphatidyl choline by dgat1 inhibition |
AU2009286734A1 (en) * | 2008-08-26 | 2010-03-04 | Boehringer Ingelheim International Gmbh | Thienopyrimidines for pharmaceutical compositions |
US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
TWI468402B (zh) | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β-類澱粉生成之化合物 |
AR077695A1 (es) | 2009-08-04 | 2011-09-14 | Schering Corp | Derivados de pirimidina como inhibidores del factor ixa |
WO2011106168A1 (en) | 2010-02-24 | 2011-09-01 | Dcam Pharma Inc | Purine compounds for treating autoimmune and demyelinating diseases |
MX2013003695A (es) | 2010-10-01 | 2013-05-20 | Bayer Ip Gmbh | Combinaciones que contienen n-(2-arilamino) arilsulfonamida sustituida. |
US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
US9447087B2 (en) | 2011-09-23 | 2016-09-20 | University Of Utah Research Foundation | Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders |
AU2012363558C1 (en) | 2011-12-30 | 2019-08-29 | Hanmi Pharm Co., Ltd. | Thieno[3,2-d]pyrimidine derivatives having inhibitory activity for protein kinases |
EP2831080B1 (en) | 2012-03-29 | 2017-03-15 | Francis Xavier Tavares | Lactam kinase inhibitors |
US10280168B2 (en) | 2012-03-30 | 2019-05-07 | Agency For Science, Technology And Research | Bicyclic heteroaryl derivatives as MNK1 and MNK2 modulators and uses thereof |
GB201205669D0 (en) | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
US20150057243A1 (en) | 2012-04-02 | 2015-02-26 | Northern University | Compositions and Methods for the Inhibition of Methyltransferases |
EP2852593A1 (en) * | 2012-05-21 | 2015-04-01 | Bayer Pharma Aktiengesellschaft | Substituted pyrrolopyrimidines |
TW201412740A (zh) | 2012-09-20 | 2014-04-01 | Bayer Pharma AG | 經取代之吡咯并嘧啶胺基苯并噻唑酮 |
EP2917185B1 (en) * | 2012-11-09 | 2017-05-10 | Evotec International GmbH | Sulfoximine substituted quinazolines for pharmaceutical compositions |
GB2508652A (en) | 2012-12-07 | 2014-06-11 | Agency Science Tech & Res | Heterocyclic piperazine derivatives |
EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
US20160287589A1 (en) | 2013-02-20 | 2016-10-06 | Bayer Pharma Aktiengesellschaft | Substituted-imidazopyridazines |
TW201605867A (zh) | 2013-11-20 | 2016-02-16 | 拜耳製藥公司 | 噻吩并嘧啶 |
TWI713455B (zh) * | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | MnK抑制劑及其相關方法 |
KR20170095985A (ko) * | 2014-12-19 | 2017-08-23 | 바이엘 파마 악티엔게젤샤프트 | Mknk1 및 mknk2 억제제로서의 피라졸로피리딘아민 |
JP6888006B2 (ja) | 2015-10-29 | 2021-06-16 | イーフェクター セラピューティクス, インコーポレイテッド | Mnk1およびmnk2を阻害するピロロ−、ピラゾロ−、イミダゾ−ピリミジンおよびピリジン化合物 |
EA201891049A1 (ru) | 2015-10-29 | 2018-10-31 | Эффектор Терапьютикс, Инк. | Изоиндолиновые, азаизоиндолиновые, дигидроинденоновые и дигидроазаинденоновые ингибиторы mnk1 и mnk2 |
WO2017087808A1 (en) | 2015-11-20 | 2017-05-26 | Effector Therapeutics, Inc. | Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers |
GB201520500D0 (en) | 2015-11-20 | 2016-01-06 | Medical Res Council Technology | Compounds |
GB201520499D0 (en) | 2015-11-20 | 2016-01-06 | Medical Res Council Technology | Compounds |
-
2015
- 2015-06-23 TW TW104120090A patent/TWI713455B/zh active
- 2015-06-24 BR BR112016029916-7A patent/BR112016029916B1/pt active IP Right Grant
- 2015-06-24 ES ES15742147T patent/ES2728201T3/es active Active
- 2015-06-24 CN CN201580046203.7A patent/CN106795162B/zh active Active
- 2015-06-24 JP JP2016575379A patent/JP6615797B2/ja active Active
- 2015-06-24 CA CA2953365A patent/CA2953365C/en active Active
- 2015-06-24 EA EA201790078A patent/EA033920B1/ru not_active IP Right Cessation
- 2015-06-24 AU AU2015279984A patent/AU2015279984B2/en active Active
- 2015-06-24 EP EP19158973.8A patent/EP3521289B1/en active Active
- 2015-06-24 NZ NZ728007A patent/NZ728007A/en unknown
- 2015-06-24 CN CN201910556784.9A patent/CN110183449B/zh active Active
- 2015-06-24 KR KR1020177002139A patent/KR102460389B1/ko active IP Right Grant
- 2015-06-24 MY MYPI2016704761A patent/MY189363A/en unknown
- 2015-06-24 EP EP15742147.0A patent/EP3160966B1/en active Active
- 2015-06-24 WO PCT/US2015/037416 patent/WO2015200481A1/en active Application Filing
- 2015-06-24 PE PE2016002761A patent/PE20170321A1/es unknown
- 2015-06-24 SG SG10201811384TA patent/SG10201811384TA/en unknown
- 2015-06-24 DK DK19158973.8T patent/DK3521289T3/da active
- 2015-06-24 FI FIEP19158973.8T patent/FI3521289T3/fi active
- 2015-06-24 MX MX2016017030A patent/MX2016017030A/es active IP Right Grant
- 2015-06-24 DK DK15742147.0T patent/DK3160966T3/da active
- 2015-06-24 US US14/748,990 patent/US9382248B2/en active Active
- 2015-06-24 SG SG11201610511YA patent/SG11201610511YA/en unknown
- 2015-06-24 ES ES19158973T patent/ES2967536T3/es active Active
-
2016
- 2016-06-21 US US15/187,854 patent/US9669031B2/en active Active
- 2016-12-14 IL IL249557A patent/IL249557B/en unknown
- 2016-12-15 PH PH12016502504A patent/PH12016502504A1/en unknown
- 2016-12-22 CL CL2016003293A patent/CL2016003293A1/es unknown
-
2017
- 2017-01-11 ZA ZA2017/00241A patent/ZA201700241B/en unknown
- 2017-01-18 CO CONC2017/0000399A patent/CO2017000399A2/es unknown
- 2017-06-02 US US15/611,966 patent/US9814718B2/en active Active
- 2017-11-10 US US15/809,011 patent/US20180085368A1/en not_active Abandoned
-
2018
- 2018-11-02 US US16/178,678 patent/US20190209560A1/en not_active Abandoned
-
2019
- 2019-11-06 JP JP2019201631A patent/JP6979439B2/ja active Active
-
2021
- 2021-05-05 US US17/308,486 patent/US20210338673A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3521289T3 (da) | Mnk-inhibitorer og fremgangsmåder forbundet dermed | |
DK3215147T3 (da) | Neurodæmpende norketamin-forbindelser og fremgangsmåder | |
DK3380101T3 (da) | Eif4-a-inhiberende forbindelser og fremgangsmåder relateret dertil | |
DK3205650T3 (da) | Egfr-hæmmer og fremstilling og anvendelse deraf | |
DK3210977T3 (da) | Hidtil ukendt aminoalkylbenzothiazepinderivat og anvendelse deraf | |
DK3258951T3 (da) | Anti-pvrig antistoffer og fremgangsmåder for anvendelse | |
DK3172213T3 (da) | Makrocykliske kinasehæmmere og anvendelser deraf | |
DK3218358T3 (da) | Ifluorometyl-aminopyridiner og difluorometyl-aminopyrimidiner | |
DK3227336T3 (da) | Anti-CD79b-antistoffer og fremgangsmåder til anvendelse | |
DK3200615T3 (da) | Kaloriefrie sødestoffer og fremgangsmåder til syntetisering | |
DK3193611T3 (da) | Mk2-inhibitorer og anvendelser deraf | |
DK3229838T3 (da) | Anti-C10orf54-antistoffer og anvendelser deraf | |
DK3126388T3 (da) | Anti-EGFRvIII-antistoffer og anvendelser deraf | |
DK3015526T3 (da) | Hydrofluorolefinbaseret sammensætning og anvendelse deraf | |
DK3116911T3 (da) | Anti-mcam-antistoffer og tilhørende fremgangsmåder til anvendelse | |
DK3161139T3 (da) | Tlr-4-specifikke aptamerer og anvendelser heraf | |
DK3089971T3 (da) | Forbindelser og fremgangsmåder til anvendelse | |
DK3265641T3 (da) | Stigørenhed og fremgangsmåde | |
DK3209773T3 (da) | Prolintolerante tripeptidylpeptidaser og anvendelser deraf | |
DK3233105T3 (da) | Hidtil ukendt kombination og anvendelse | |
DK3142659T3 (da) | Hiv-1 proteasehæmmere og anvendelser deraf | |
DK3474883T3 (da) | Komplementinhibitorer og anvendelser deraf | |
DK3146320T3 (da) | Detekteringsanordning og fremgangsmåde | |
DK3240821T3 (da) | Lavdosis gashydrathæmmersammensætning og tilhørende fremgangsmåde | |
DK3194583T3 (da) | Ikke-fucosyleret protein og fremgangsmåder dermed |