JP2006503628A - 創傷の吸引、灌注および洗浄用装置 - Google Patents
創傷の吸引、灌注および洗浄用装置 Download PDFInfo
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- JP2006503628A JP2006503628A JP2004546200A JP2004546200A JP2006503628A JP 2006503628 A JP2006503628 A JP 2006503628A JP 2004546200 A JP2004546200 A JP 2004546200A JP 2004546200 A JP2004546200 A JP 2004546200A JP 2006503628 A JP2006503628 A JP 2006503628A
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Abstract
Description
a) 公知の吸引および/または灌注治療系における前記短所の少なくともいくつかを未然に防止することと、
b) 創傷滲出物から創傷治癒に有害である物質を除去することができ、一方、創傷底と接触して創傷治癒の促進に有益である物質を保持することのできる治療系を提供することである。
a) 公知の透析系における前記短所の少なくともいくつかを未然に防止することと、
b) 創傷滲出物から創傷治癒に有害である物質を除去することができ、一方、創傷底と接触して創傷治癒の促進に有益である物質を保持することのできる治療系を
c) 身体の全身に影響をおよぼすことなく提供することである。
a) 公知の透析系における前記短所の少なくともいくつかを未然に防止することと、
b) 創傷滲出物から創傷治癒に有害である物質を除去することができ、一方、創傷底と接触して創傷治癒の促進に有益である物質を保持することのできる
c) 携帯型の治療系を提供することである。
a) i) 創傷を覆って相対的に液密な封止部あるいは閉鎖部を形成することのできる裏張層と、流体供給管へ接続され、創傷対向面を貫通しかつ/またはその下方を通る少なくとも1つの入口管と、流体排出管へ接続され、創傷対向面を貫通しかつ/またはその下方を通る少なくとも1つの出口管とを有しており、その入口管あるいはそれぞれの入口管およびその出口管あるいはそれぞれの出口管が創傷対向面を貫通しかつ/またはその下方を通る箇所は、創傷を覆って相対的に液密な封止部あるいは閉鎖部を形成し、少なくとも1つの入口管は流体再循環管に接続され、少なくとも1つの出口管は流体排出管に接続されている適合性創傷ドレッシングと、
ii) 流体排出管に接続された少なくとも1つの入口部と流体再循環管に接続された少なくとも1つの出口部とを有している流体洗浄手段と
を備えている流体流路、
b) 第2流体供給管によって(場合によってはあるいは必要に応じて、供給と再循環との流れを切り換える手段を介して)前記流路の完全体に接続された流体貯蔵器、
c) 流体を前記創傷ドレッシングと前記流体洗浄手段とによって、また、場合によってはあるいは必要に応じて前記流体供給管によって、移動させる装置、および
d) 場合によっては、前記流体貯蔵器から前記流体供給管(場合によってはあるいは必要に応じて、流れを切り換える前記手段を介して)を通して流体が前記流路を満たすことができるように、かつ、前記流路を通して前記装置によって再循環することができるように、前記流路から流体を放出する手段
を備えていることを特徴とする創傷の吸引、灌注および/または洗浄用装置が提供される。
a) 流体貯蔵器に連通するが、
b) 流体再循環管に近接し、かつ、
c) 逆の場合も同じである
ことを可能にする任意の形態を採ることができる。
a) 創傷滲出物および/または
b) 洗浄流体から例えば透析ユニットのような系における選択透過性完全体を通過する流体
のそれへの連続的添加によって増大するときに起きるであろう。
a) 創傷滲出物および/または
b) 洗浄流体から選択透過性完全体、例えば透析ユニットのような二相系におけるポリマー製のフィルム、シートあるいは膜を通過する流体
のそれへの連続的添加によって増大する。
a)過剰な物質を灌注流体に初めに添加し、必要に応じて再循環の量を連続的添加によって増やすことができ、または
b)忌避薬のコーティングを、流体に直接接触する再循環通路における任意の箇所あるいは任意の完全体、例えば流体洗浄手段かあるいは所望の管で使用することができる。
シャトルポンプ :流体を1分間に2〜50mlの速度で移動させる揺動シャト ル機構がある
ダイアフラムポンプ :1つあるいは2つの柔軟性ダイアフラムの脈動によって液体 が変位し、チェックバルブによって流体の流れの方向が調節さ れる
ピストンポンプ :ピストンによりチェックバルブを通して流体が汲み上げら れ、とりわけ創傷底へ正圧および/または負圧が加えられる
のような往復ポンプ、
遠心ポンプ
柔軟性インペラーポンプ :ゴム弾性のあるインペラーがあり、インペラーブレー ドと成形されたハウジングとの間の流体を阻止し、ポン プハウジングを通して流体を洗い流す
前進性キャビティポンプ :協働するスクリューローターとステーターとがあり、 とりわけ、より高い粘度と微粒子で満たされた滲出物の ためのもの
ロータリーベーンポンプ :駆動軸に取り付けられ、そのスピンのような脈動によ ることなく流体を移動させる羽根付きディスクがある。 出力はポンプを損傷することなく制限することができる
蠕動ポンプ :ローターアームに周縁ローラーがあり、柔軟な流体再 循環管に作用して管の中における流体をローターの方向 へ押す
真空ポンプ :圧力調整器がある
のような回転ポンプ。
創傷治癒過程の最適特性についての
a) 灌注流体および/または創傷からの創傷滲出物における適切なあるいは所望の流体容積の流速と、
b) 創傷底へ正圧あるいは負圧を加えることが適切であるかどうかあるいは望まれているかどうかということと、創傷底ヘのそのような圧力の大きさと
によって、また、携帯性、消費電力、および汚染からの隔離のような諸因子によって、大きく左右されるであろう。
a) 限外濾過ユニットあるいは化学吸収ユニットおよび/または化学吸着ユニットのような 単相系、または
b) 透析ユニットあるいは二相性抽出ユニットのような二相系
であってよい流体洗浄手段が設けられている。
遊離基のような酸化剤、例えば過酸化物および超酸化物、
II価鉄およびIII価鉄、
創傷底における酸化ストレスに含まれるすべてのもの、
セリンプロテアーゼ、例えばエラスターゼおよびトロンビン、システインプロテアーゼ、マトリックスメタロプロテアーゼ、例えばコラゲナーゼ、およびカルボキシル(酸)プロテアーゼのようなプロテアーゼ、
リポ多糖類のようなエンドトキシン、
ホモセリンラクトン誘導体、例えばオキソアルコール誘導体のような自己誘導物質シグナル分子、
トロンボスポジン-1(TSP-1)、プラスミノゲン・アクチベータ・阻害剤、あるいはアンギオスタチン(プラスミノゲンフラグメント)のような血管形成阻害剤、
腫瘍壊死因子アルファ(TNFα)およびインターロイキン1ベータ(IL-1β)のような炎症誘発性サイトカイン、
および
リポ多糖類、例えばヒスタミンのような炎症剤
が含まれる。
炭酸水素イオンのようなイオン種、
創傷底における酸化ストレスを解放するためのアスコルビン酸(ビタミンC)およびビタミンEのようなビタミン、およびこれらの安定誘導体、およびこれらの混合物、
二水素リン酸カリウム/リン酸一水素二ナトリウムのようなpH緩衝剤、
創傷の痛みまたはドレッシングに関連した炎症あるいは痛みを緩和するためのリドカイン/リグノカイン塩酸塩およびキシロカイン(アドレナリン、リドカイン)のような局所麻酔薬/局所麻酔剤および/または抗炎症剤
アミノ酸、糖類、低分子量組織構成単位および微量元素のような創傷細胞の増殖を促進するための栄養素および他の細胞培養培地種、および
空気、窒素、酸素および/または酸化窒素のような気体
が含まれる。
創傷底における酸化ストレスを除去するための、3-ヒドロキシチラミン(ドーパミン) 、アスコルビン酸(ビタミンC)、ビタミンEおよびグルタチオン、およびこれらの安定誘導体、およびこれらの混合物のような酸化防止剤および遊離基捕捉剤、
デスフェリオキサミン(DFO)、3-ヒドロキシチラミン(ドーパミン)のようなIII価鉄キレート化剤(III価鉄は創傷底における酸化ストレスに含まれる)のような遷移金属イオンキレート化剤のような金属イオンキレート化剤および/またはイオン交換剤、
III価鉄還元剤、
TIMPおよびアルファ1-アンチトリプシン(AAT)のようなプロテアーゼ阻害剤、4-(2-アミノエチル)-ベンゼンスルホニルフルオライド(AEBSF、ペファブロック)およびNα-p-トシル-リシンクロロメチルケトン(TLCK)およびε-アミノカプロイル-p-クロロベンジルアミドのようなセリンプロテアーゼ阻害剤、システインプロテアーゼ阻害剤、マトリックスメタロプロテアーゼ阻害剤、カルボキシル(酸)プロテアーゼ阻害剤、
創傷治癒に有害である酸化還元感受性遺伝子の創傷滲出物の中への発現を引き起こす物質の除去による創傷治癒の促進に潜在的に有益であるかあるいは実際に有益である犠牲的酸化還元物質、
酵素であってもよい自己誘導物質シグナル分子分解剤、および
リポ多糖類、例えばペプチドミメティックス(peptidomimetics)に結合しあるいは分解する抗炎症物質。
不均質樹脂、例えば、
金属捕捉剤、すなわち
3-(ジエチレントリアミノ)プロピル-官能化シリカゲル、
2-(4-(エチレンジアミノ)ベンゼン)エチル-官能化シリカゲル、
3-(メルカプト)プロピル-官能化シリカゲル、
3-(1-チオウレイド)プロピル-官能化シリカゲル、
トリアミンテトラアセテート-官能化シリカゲル、
あるいは求電子的捕捉剤、すなわち
4-カルボキシブチル-官能化シリカゲル、
4-エチルベンゼンスルホニルクロライド-官能化シリカゲル、
プロピオニルクロライド-官能化シリカゲル、
3-(イソシアノ)プロピル-官能化シリカゲル、
3-(チオシアノ)プロピル-官能化シリカゲル、
3-(2-無水コハク酸)プロピル-官能化シリカゲル、
3-(マレイミド)プロピル-官能化シリカゲル、
あるいは求核性捕捉剤、すなわち
3-アミノプロピル-官能化シリカゲル、
3-(エチレンジアミノ)-官能化シリカゲル、
2-(4-(エチレンジアミノ))プロピル-官能化シリカゲル、
3-(ジエチレントリアミノ)プロピル-官能化シリカゲル、
4-エチルベンゼンスルホンアミド-官能化シリカゲル、
2-(4-トルエンスルホニルヒドラジノ)エチル-官能化シリカゲル、
3-(メルカプト)プロピル-官能化シリカゲル、
ジメチルシロキシ-官能化シリカゲル、
あるいは塩基捕捉剤あるいは酸捕捉剤、すなわち
3-(ジメチルアミノ)プロピル-官能化シリカゲル、
3-(1,3,4,6,7,8-ヘキサヒドロ-2H-ピリミド-[1,2-α] ピリミジノ)プロピル-官能化シリカゲル、
3-(1-イミダゾル-1-イル)プロピル-官能化シリカゲル、
3-(1-モルホリノ)プロピル-官能化シリカゲル、
3-(1-ピペラジノ)プロピル-官能化シリカゲル、
3-(1-ピペリジノ)プロピル-官能化シリカゲル、
3-(4,4’-トリメチルジピペリジノ)プロピル-官能化シリカゲル、
2-(2-ピリジル)エチル-官能化シリカゲル、
3-(トリメチルアンモニウム)プロピル-官能化シリカゲル、
あるいは反応物、すなわち
3-(1-シクロヘキシルカルボジイミド)プロピル-官能化シリカゲル、
TEMPO-官能化シリカゲル、
2-(ジフェニルホスフィノ)エチル-官能化シリカゲル、
2-(3,4-シクロヘキシルジオール)プロピル-官能化シリカゲル、
3-(グリシドキシ)プロピル-官能化シリカゲル、
2-(3,4-エポキシシクロヘキシル)プロピル-官能化シリカゲル、
1-(アリル)メチル-官能化シリカゲル、
4-ブロモプロピル-官能化シリカゲル、
4-ブロモフェニル-官能化シリカゲル、
3-クロロプロピル-官能化シリカゲル、
4-ベンジルクロライド-官能化シリカゲル、
2-(カルボメトキシ)プロピル-官能化シリカゲル、
3-(4-ニトロベンズアミド)プロピル-官能化シリカゲル、
3-(ウレイド)プロピル-官能化シリカゲル、
または前記のものの任意の組み合わせ
のようなシリカ保持型反応物。
セリンプロテアーゼ、例えばエラスターゼおよびトロンビン、システインプロテアーゼ、マトリックスメタロプロテアーゼ、例えばコラゲナーゼ、およびカルボキシル(酸)プロテアーゼのようなプロテアーゼ、
リポ多糖類のようなエンドトキシン、
トロンボスポンジン-1(TSP-1)、プラスミノゲン・アクチベータ・阻害剤、あるいはアンギオスタチン(プラスミノゲンフラグメント)のような血管形成阻害剤、
腫瘍壊死因子アルファ(TNFα)およびインターロイキン1ベータ(IL-1β)のような炎症誘発性サイトカイン、
遊離基のような酸化剤、例えば過酸化物および超酸化物、および
金属イオン、例えばII価鉄およびIII価鉄、創傷底における酸化ストレスに含まれるすべてのもの。
4-(2-アミノエチル)-ベンゼンスルホニルフルオライド(AEBSF、ペファブロック)およびNα-p-トシル-L-リシンクロロメチルケトン(TLCK)およびε-アミノカプロイル-p-クロロベンジルアミドのようなセリンプロテアーゼ阻害剤、システインプロテアーゼ阻害剤、マトリックスメタロプロテアーゼ阻害剤、およびカルボキシル(酸)プロテアーゼ阻害剤、のようなプロテアーゼ阻害剤、
リポ多糖類、例えばペプチドミメティックスを結合しあるいは分解するための抗炎症物質のような結合剤および/または分解剤、
創傷底における酸化ストレスを除去するための、3-ヒドロキシチラミン(ドーパミン) 、アスコルビン酸(ビタミンC)、ビタミンEおよびグルタチオン、およびこれらの安定誘導体、およびこれらの混合物のような酸化防止剤、
デスフェリオキサミン(DFO)、3-ヒドロキシチラミン(ドーパミン)のようなキレート化剤および/またはイオン交換剤。
a) 灌注流体および/または創傷滲出物が創傷ドレッシングから流れるとともに、
b) 創傷治癒を促進するのに有益である物質が依然として含有されている洗浄ずみ流体が再循環管へ戻され、さらに
c) (前記手段が透析ユニットのような二相系の形態に設けられているときに)洗浄流体が前記手段へ入りかつ前記手段から出る
複数の導管には、
灌注流体および/または滲出物、洗浄ずみ流体および洗浄流体の連続的通過を防止するために、
i) 流れを切り換えるとともに
ii) これらの導管の端部を覆って直接的な液密の封止部あるいは閉鎖部をもたらし、かつ、そのように露出させたこの発明の装置の残り部分に管を協働させる
モジュール式の切断および離脱の手段が備わっているのが好ましい。
a) 排出管および/または再循環管へ流体を放出する手段、
b) 供給と再循環との間で流れを切り換える手段、および/または
c) 創傷底を覆ってかつ流体洗浄手段を通して流体を移動させる手段
によって、必要に応じて調整されるであろう。
a) 創傷の吸引、灌注および洗浄用装置が限外濾過ユニットのような単相系のものであり、
b) 創傷が強滲出状態になく、かつ、
c) 流体を流体貯蔵器から創傷の中へ流入させることが適切でないかあるいは望ましくないときには、
再循環中における流体の均衡の変化はまったくないかあるいは無視することができる。
a) 創傷の吸引、灌注および洗浄用装置が限外濾過ユニットのような単相系のものであり、
b) 創傷が強滲出状態にあり、かつ/または
c) 流体を流体貯蔵器から創傷の中へ流入させることが適切であるかあるいは望ましいときには、
再循環中における流体の均衡には正の変化がある。
b) 供給と再循環との間で流れを切り換える手段、および/または
c) 流体を移動させる手段
によって再循環管における流体の所望の均衡を維持するための他の組み合わせおよび必要な調整は、当業者にとって明らかであろう。
流体供給管へ接続され、創傷対向面を貫通しかつ/またはその下方を通る少なくとも1つの入口管と、
流体排出管へ接続され、創傷対向面を貫通しかつ/またはその下方を通る少なくとも1つの出口管とを有しており、
その入口管あるいはそれぞれの入口管およびその出口管あるいはそれぞれの出口管が創傷対向面を貫通しかつ/またはその下方を通る箇所は、創傷を覆って相対的に液密な封止部あるいは閉鎖部を形成していることを特徴とする適合性創傷ドレッシングが提供される。
a) 公知の吸引および/または灌注治療における前記短所の少なくともいくつかを未然に防止することと、
b) i)創傷滲出物から創傷治癒に有害である物質を除去することができ、一方、創傷底と接触して創傷治癒の促進に有益である物質を保持することができ、かつ/または
ii)創傷底と接触して創傷治癒の促進に有益である物質の活性量を含有する流体を創傷底に接触している創傷の中へかつ/または創傷を貫通して流すことのできる
治療系を提供することである。
創傷(5)を覆って相対的に液密な封止部あるいは閉鎖部(4)を形成することのできる裏張層(3)を有している適合性創傷ドレッシング(2)と、
流体供給管(7)へ接続され、箇所(8)で裏張層(3)の創傷対向面を貫通する1つの入口管(6)と、
流体排出管(10)へ接続され、箇所(11)で創傷対向面を貫通する1つの出口管(9)とを備えてなり、
入口管および出口管が貫通しかつ/または創傷対向面の下方を通る箇所(8)(11)は、創傷を覆って相対的に液密な封止部あるいは閉鎖部を形成し、
入口管(6)は、流れを供給と再循環とに切り換える手段、ここではT字バルブ(14)を介して、流体供給管(7)により、流体貯蔵器(12)と、放出手段、ここでは例えば捕集バッグ(図示略)へ廃棄するための放出用T字バルブ(16)を有している流体再循環管(13)とに接続され、
出口管(9)は、流体排出管(10)へ、そしてまた、流体再循環管(13)およびT字バルブ(14)を介して入口管(6)へ接続された、ここでは限外濾過ユニットの形態にある流体洗浄手段(17)と、
そのロータ(図示略)における周縁ローラで流体再循環管(13)に作用して創傷の上に低い負圧を加える、ここでは蠕動ポンプ(18)、例えば好ましくは携帯用小型蠕動ポンプである、創傷および流体洗浄手段(17)を通して流体を移動させる装置とに接続されている。
a)ポリマー製のフィルム、シートあるいは膜の一方表面の向こう側へ洗浄流体を通過させる第1チャンバー(25)と、
b)創傷および流体貯蔵器(12)からの循環流体を通過させて有害物質を除去する第2チャンバー(26)と
の中へ分配するフィルム、シートあるいは膜が備わっている。
この単相系によれば、およそ3つの対数によって0.22μmフィルターを通過した後に創傷回路から細菌細胞をただちに除去することができるとともに、循環する細菌の全数を徐々に減少させることができた。
a) 5mlのリン酸緩衝生理食塩水(PBS)
b) デンプン対照(40mg/ml、120mg/mlおよび200mg/ml)あるいは
c) 溶液中におけるデンプン−デスフェリオキサミン(DFO)コンジュゲート(バイオメディカル・フロンティアーズ・インコーポレーテッド(Biomedical Frontiers Inc.)から供給されたもの)(40mg/ml、120mg/mlおよび200mg/ml)
流体の抗菌活性−阻害ゾーンアッセイの結果によれば、創傷回路におけるゲンタマイシンのレベルは、2つの回路における薬剤のレベルが互いに接近するにつれて遅くなる増加率で、230分にわたって安定的に増大することを示している。透析液回路におけるゲンタマイシンのレベルは、薬剤が透析液回路から創傷回路まで移動すると、予想どおり安定的に減少することを示している。臨床業務において有用である圧力および流速では、創傷治癒のための薬剤は、許容できる量と許容できる時間尺度で供給することができる。
a) 蒸留水の中で調製された2mg/mlのNADP(NADP)
b) NADP保存溶液の中で調製された2mg/mlのグルタチオン還元酵素(GR+NADP)あるいは
c) 蒸留水の中で3重に調製された2mg/mlのグルタチオン還元酵素(GR)
GSSGは、GRとその補因子NADPとの組み合わせによって、GR単独あるいはNADP単独によるときよりもかなり多い程度まで使い尽くされた。従って、この使い尽くしは非特異的結合に起因するものではない。前記の酵素濃度と補因子の濃度では、6時間でおよそ40%のGSSGが使い尽くされた。
Claims (10)
- a) i) 創傷を覆って相対的に液密な封止部あるいは閉鎖部を形成することのできる裏張層と、流体供給管へ接続され、創傷対向面を貫通しかつ/またはその下方を通る少なくとも1つの入口管と、流体排出管へ接続され、創傷対向面を貫通しかつ/またはその下方を通る少なくとも1つの出口管とを有しており、その入口管あるいはそれぞれの入口管およびその出口管あるいはそれぞれの出口管が創傷対向面を貫通しかつ/またはその下方を通る箇所は、創傷を覆って相対的に液密な封止部あるいは閉鎖部を形成し、少なくとも1つの入口管は流体再循環管に接続され、少なくとも1つの出口管は流体排出管に接続されている適合性創傷ドレッシングと、
ii) 流体排出管に接続された少なくとも1つの入口部と流体再循環管に接続された少なくとも1つの出口部とを有している流体洗浄手段と
を備えている流体流路、
b) 第2流体供給管によって(場合によってはあるいは必要に応じて、供給と再循環との流れを切り換える手段を介して)前記流路の完全体に接続された流体貯蔵器、
c) 流体を前記創傷ドレッシングと前記流体洗浄手段とによって、また、場合によってはあるいは必要に応じて前記流体供給管によって、移動させる装置、および
d) 場合によっては、前記流体貯蔵器から前記流体供給管(場合によってはあるいは必要に応じて、流れを切り換える前記手段を介して)を通して流体が前記流路を満たすことができるように、かつ、前記流路を通して前記装置によって再循環することができるように、前記流路から流体を放出する手段
を備えていることを特徴とする創傷の吸引、灌注および/または洗浄用装置。 - 単相系である流体洗浄手段を備え、創傷からの循環流体が前記流体洗浄手段を通過し、創傷治癒に有害である物質が、前記流体洗浄手段の中における別の流体と直接または間接的に接触する循環流体によることなく除去されることを特徴とする請求項1に記載の装置。
- 二相系である流体洗浄手段を備え、創傷からの循環流体が前記流体洗浄手段を通過し、創傷治癒に有害である物質が、前記流体洗浄手段の中における別の流体と直接または間接的に接触する循環流体によって除去されることを特徴とする請求項1に記載の装置。
- 前記流体洗浄手段において、創傷からの循環流体と前記流体洗浄手段における他の流体とが、創傷治癒に有害である物質を選択的に透過させることのできる完全体によって分離されることを特徴とする請求項3に記載の装置。
- 前記流体洗浄手段において、創傷からの循環流体と前記流体洗浄手段における他の流体とが、創傷治癒に有害である物質を選択的に透過させることのできない完全体によって分離されることと、前記他の流体が、創傷治癒に有害である物質を除去する物質を備えかつ/またはその物質と接触することとを特徴とする請求項3に記載の装置。
- 創傷治癒に有害である物質を除去する物質が、拮抗剤、結合剤および/または分解剤、そのような有害物質についてのキレート化剤および/またはイオン交換剤、または酸化防止剤であることを特徴とする請求項3に記載の装置。
- 創傷治癒に有害である物質を除去する物質が、4-(2-アミノエチル)ベンゼンスルホニルフルオライド(AEBSF、ペファブロック)、Nα-p-トシル-L-リシンクロロメチルケトン(TLCK)、ε-アミノカプロイル-p-クロロベンジルアミド、システインプロテアーゼ阻害剤、マトリックスメタロプロテアーゼ阻害剤、カルボキシル(酸)プロテアーゼ阻害剤、抗炎症性ペプチドミメティックス、3-ヒドロキシチラミン(ドーパミン)、アスコルビン酸(ビタミンC)、ビタミンE、グルタチオン、デスフェリオキサミン(DFO)および/または3-ヒドロキシチラミン(ドーパミン)であることを特徴とする請求項3に記載の装置。
- 創傷治癒に有害である物質が、酸化剤、プロテアーゼ、エンドトキシン、自己誘導物質シグナル分子、血管形成阻害剤、炎症誘発性サイトカイン、および炎症剤であることを特徴とする請求項1に記載の装置。
- 創傷を覆って相対的に液密な封止部あるいは閉鎖部を形成することのできる創傷対向面がある裏張層を備え、かつ、
流体供給管へ接続され、創傷対向面を貫通しかつ/またはその下方を通る少なくとも1つの入口管と、
流体排出管へ接続され、創傷対向面を貫通しかつ/またはその下方を通る少なくとも1つの出口管とを有しており、
その入口管あるいはそれぞれの入口管およびその出口管あるいはそれぞれの出口管が創傷対向面を貫通しかつ/またはその下方を通る箇所は、創傷を覆って相対的に液密な封止部あるいは閉鎖部を形成している
ことを特徴とする請求項1に記載の装置に使用する適合性創傷ドレッシング。 - 請求項1に記載の創傷の吸引、灌注および/または洗浄用装置を使用して創傷治癒を促進する創傷治療方法。
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JP2008538959A (ja) * | 2005-04-27 | 2008-11-13 | スミス アンド ネフュー ピーエルシー | 創傷治療機器および方法 |
JP2008538962A (ja) * | 2005-04-27 | 2008-11-13 | スミス アンド ネフュー ピーエルシー | 創傷治療機器および方法 |
JP2009536852A (ja) * | 2006-05-11 | 2009-10-22 | カリプト メディカル インコーポレーション | 外傷治療用装置及び方法 |
JP2011505887A (ja) * | 2007-12-06 | 2011-03-03 | スミス アンド ネフュー ピーエルシー | ドレッシング |
JP2011509160A (ja) * | 2008-01-08 | 2011-03-24 | ブルースカイ・メディカル・グループ・インコーポレーテッド | 持続性可変負圧創傷治療法およびその制御法 |
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- 2018-10-15 US US16/160,118 patent/US20190046360A1/en not_active Abandoned
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JP2014516711A (ja) * | 2011-05-25 | 2014-07-17 | ケーシーアイ ライセンシング インコーポレイテッド | 組織部位における肉芽形成を促すために正圧を使用する創傷治癒システム |
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