HUE031663T2 - Immunglobulin kiméra fehérjék kémiai szintetizálási módszerei - Google Patents

Immunglobulin kiméra fehérjék kémiai szintetizálási módszerei Download PDF

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Publication number
HUE031663T2
HUE031663T2 HUE09013214A HUE09013214A HUE031663T2 HU E031663 T2 HUE031663 T2 HU E031663T2 HU E09013214 A HUE09013214 A HU E09013214A HU E09013214 A HUE09013214 A HU E09013214A HU E031663 T2 HUE031663 T2 HU E031663T2
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HU
Hungary
Prior art keywords
factor
urg
protein
biologically active
molecule
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HUE09013214A
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English (en)
Inventor
Adam R Mezo
Robert T Peters
Original Assignee
Biogen Hemophilia Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33458764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE031663(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Hemophilia Inc filed Critical Biogen Hemophilia Inc
Publication of HUE031663T2 publication Critical patent/HUE031663T2/hu

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Claims (4)

  1. =ifëhé:iia-ïê- kémiai szintetízáfási módszerei Igénypontok
    1- Első és második polipeplld láncot tartalmazó monornerdimer hibrid kiméra fehérje Sapta||?|?isáF|í szolgáló módszer. ahol a* említett első lánc egy bidíógíaífeg: aktív molekulát és egy olyan ímosungiobulin konstans régió legs iá Pb egy készét foglalja maglMfg amply heRn-kötőpartnes, a* említeti második iáin lk€g Így plyap ím»óIÍÓMÍ?f 'tddStâM fegM áepiább egy részét foglalja magában, áilllv IÄ-kőtőpartusr Mrmiíyen biológiailag nkhv meíekufe vagy Immunglobulin variábilis régiója Ilikul, ás a neyezettmődSMf a kövétkézökét fögíálamagabam a) fúziós íehÉrje rekombsnáns expresszálása, amely « következeket öfeii fel: fi) olyan immuôifQbutefeOoâtântfégl^-fegalâbfe-rigy része. amely hóRmkötőprínert és |i.l} olyan spíiclpg: fehérje, .^rpely. :pgrö$$2$á4fcp Cdérmjnâlfe itioéseîorbkipor őz |f immurgfebúiibi kopsfáfisrégiólánsk adbtf részén; b) tioi koiaktör hozzáadás;? az a) fébèflddïgés ej legalább egy bleidgisilag aktív,. Hőetmínália aszteínnei remfeikező mpiekyía hozzáadása, hogy hozzákapcsolja a bloíógrallag aktív molekulát sa immunglobulin konstans régió ros^énok őíitermlniilsáboaí ahol az említett spiMni fehérjéi fetéin, és alpi az említett, biológiailag aktiv molekula a következő csoportból kiválasztott paijpeptid: Ä3, Interferon, vírusos fúziós inhibitor és aívadási faktor. Az IL igénypont szerinti módszer, shoie spile ing: fehérje mutáns Ihtein, amely nem vágja ki sitiiéiig során a fúziós fehérjét, de áz smiitétt tlolszterz iálkötja:, :1< M: t, vagy a 2. igénypont szerlni nfeöszer, ahol a tlPi kofaktör MESöíá.
  2. 4, Az l~3k igénypontok bármelyike szerinti módszer, aboi a monomer-dimer hibrid dlmerlkusan kapcsolt monomer dimer hibrid. #v Az 1-4. igénypontok bármelyike szerlptl: móPPfe aboi a biológiailag aktív molekula a következők közül kiválasztott ájyadlsi fekíot: Vli, faktor, IX. faktor, XI, faktoiyXll. faktor, fíbrinogén, protrombin, y, faktor, yik fáktpr, X. faktpry Xiíii. faktor és von piliebrand faktor. 4 A.? 1~4 igénypontok barmehnke uerintJ módszer. ahoi as aivadási faktor VU. faktor vagy Viía faktor. 7<: A? :Mt. igénypontok bármelyike «épi m âlvadisi faktor VUS, faktor. 4 As Ir-4. igénypontok |$rmei$k# jpeftnîi módszer,. ahol m ÄÄsi faktor fkefákför vagy íXa faktor. §. M:Mk igénypontok bármelyike særintt módszer, ahol mind a bioíigjifiag aktívlmafeküfe mind ax immyngiohuUn konstans régió eíoáíiításá mkombináns úton tör-énik. $&amp; Ai 1~8, igénypontok blrméiyike szerinti ii», ahol: a blologiaiiag aÄ molekula öloáiiíiifea kémiai szintézissel történik. 1¾. As i~m igénypontok bármelyik líóéds» 4hóí n Pckmkótöpartner ke vagy utóbbi rragmems.:
  3. 12, Ag 1-iL Igénypontok irérmeiyiké Meíinfi: módszer, ahoi a monoroer-dimer hibrid linkért is tartalmas.
  4. 13, As :1-12, igénypontok bármaiylko mofM Jttódsasn ahoi M opusra oidatbar; korúi sor. té. ;Ar :1.--12:. igénypontok pirmeiyÉé szerinti módszen aho! m «ijárásra szilárd imrdozon korúi sor. kS, A |4. fjgéoypohf*t«ri'rÂkrtié:^2à|gÂi a sxiilrd^ordosó kitin gyöngy.
HUE09013214A 2003-05-06 2004-05-06 Immunglobulin kiméra fehérjék kémiai szintetizálási módszerei HUE031663T2 (hu)

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