FI4219492T3 - Heterosyklisiä yhdisteitä immunomodulaattoreina - Google Patents
Heterosyklisiä yhdisteitä immunomodulaattoreina Download PDFInfo
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- FI4219492T3 FI4219492T3 FIEP23152736.7T FI23152736T FI4219492T3 FI 4219492 T3 FI4219492 T3 FI 4219492T3 FI 23152736 T FI23152736 T FI 23152736T FI 4219492 T3 FI4219492 T3 FI 4219492T3
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- Prior art keywords
- methyl
- tetrahydro
- imidazo
- inhibitor
- cancer
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- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000002955 immunomodulating agent Substances 0.000 title 1
- 229940121354 immunomodulator Drugs 0.000 title 1
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- 125000006526 (C1-C2) alkyl group Chemical group 0.000 claims 67
- 239000003112 inhibitor Substances 0.000 claims 67
- LKXGYGYFPTZHLC-UHFFFAOYSA-N bicyclo[2.2.1]heptane-4-carboxylic acid Chemical compound C1CC2CCC1(C(=O)O)C2 LKXGYGYFPTZHLC-UHFFFAOYSA-N 0.000 claims 59
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 51
- 206010028980 Neoplasm Diseases 0.000 claims 48
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 47
- 125000004938 5-pyridyl group Chemical group N1=CC=CC(=C1)* 0.000 claims 37
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 30
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- 150000001875 compounds Chemical class 0.000 claims 24
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- 125000001424 substituent group Chemical group 0.000 claims 18
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 16
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 12
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- KKVYYGGCHJGEFJ-UHFFFAOYSA-N 1-n-(4-chlorophenyl)-6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Chemical compound N=1C=CC2=C(NC=3C(=CC=CN=3)C=3C=4N=CNC=4N=CN=3)C(C)=CC=C2C=1NC1=CC=C(Cl)C=C1 KKVYYGGCHJGEFJ-UHFFFAOYSA-N 0.000 claims 2
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- C07D471/04—Ortho-condensed systems
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| US201862670249P | 2018-05-11 | 2018-05-11 | |
| US201862688164P | 2018-06-21 | 2018-06-21 |
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| FIEP23152736.7T FI4219492T3 (fi) | 2018-05-11 | 2019-05-10 | Heterosyklisiä yhdisteitä immunomodulaattoreina |
| FIEP19725627.4T FI3790877T3 (fi) | 2018-05-11 | 2019-05-10 | Tetrahydroimidatso[4,5-c]pyridiinijohdannaisia pd-l1-immunomodulaattoreina |
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