DE19962924A1 - Substituierte Oxazolidinone und ihre Verwendung - Google Patents

Substituierte Oxazolidinone und ihre Verwendung

Info

Publication number
DE19962924A1
DE19962924A1 DE19962924A DE19962924A DE19962924A1 DE 19962924 A1 DE19962924 A1 DE 19962924A1 DE 19962924 A DE19962924 A DE 19962924A DE 19962924 A DE19962924 A DE 19962924A DE 19962924 A1 DE19962924 A1 DE 19962924A1
Authority
DE
Germany
Prior art keywords
alkyl
radical
hydrogen
optionally
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19962924A
Other languages
German (de)
English (en)
Inventor
Alexander Straub
Thomas Lampe
Jens Pohlmann
Susanne Roehrig
Elisabeth Perzborn
Karl-Heinz Schlemmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7934434&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19962924(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19962924A priority Critical patent/DE19962924A1/de
Priority to HN2000000267A priority patent/HN2000000267A/es
Priority to BRPI0017050-0A priority patent/BR0017050B1/pt
Priority to CA002396561A priority patent/CA2396561C/en
Priority to HU0203902A priority patent/HU226522B1/hu
Priority to AT00993610T priority patent/ATE289605T1/de
Priority to TR2002/01636T priority patent/TR200201636T2/xx
Priority to DE122009000014C priority patent/DE122009000014I1/de
Priority to SG200403830-3A priority patent/SG130939A1/en
Priority to PT00993610T priority patent/PT1261606E/pt
Priority to SK908-2002A priority patent/SK287272B6/sk
Priority to NZ519730A priority patent/NZ519730A/en
Priority to CN2006100819193A priority patent/CN1900074B/zh
Priority to EEP200200341A priority patent/EE05169B1/xx
Priority to ES04027037.3T priority patent/ES2457021T3/es
Priority to PT40270373T priority patent/PT1526132E/pt
Priority to AU28414/01A priority patent/AU775126C/en
Priority to DK00993610T priority patent/DK1261606T3/da
Priority to DE50009607T priority patent/DE50009607D1/de
Priority to DK04027037.3T priority patent/DK1526132T3/da
Priority to PL382243A priority patent/PL201121B1/pl
Priority to EP04027037.3A priority patent/EP1526132B1/de
Priority to CZ20022202A priority patent/CZ301432B6/cs
Priority to KR1020027008172A priority patent/KR100804932B1/ko
Priority to PL355665A priority patent/PL200413B1/pl
Priority to CNB2005101271139A priority patent/CN100549008C/zh
Priority to TR2004/01314T priority patent/TR200401314T2/xx
Priority to IL14989600A priority patent/IL149896A0/xx
Priority to SI200030679T priority patent/SI1261606T1/xx
Priority to RU2002120456/04A priority patent/RU2297415C2/ru
Priority to NZ537058A priority patent/NZ537058A/en
Priority to US10/181,051 priority patent/US7157456B2/en
Priority to KR1020077008192A priority patent/KR20070044075A/ko
Priority to MXPA02006241A priority patent/MXPA02006241A/es
Priority to ES00993610T priority patent/ES2237497T3/es
Priority to SI200031079T priority patent/SI1526132T1/sl
Priority to PCT/EP2000/012492 priority patent/WO2001047919A1/de
Priority to JP2001549389A priority patent/JP4143297B2/ja
Priority to CNB008189668A priority patent/CN1262551C/zh
Priority to EP00993610A priority patent/EP1261606B1/de
Priority to KR1020077020537A priority patent/KR20070094672A/ko
Priority to UA2002076161A priority patent/UA73339C2/uk
Priority to ARP000106733A priority patent/AR032436A1/es
Priority to GT200000216A priority patent/GT200000216A/es
Priority to DO2000000114A priority patent/DOP2000000114A/es
Priority to TW083120747A priority patent/TWI277615B/zh
Priority to TW089127307A priority patent/TWI226330B/zh
Priority to SV2000000245A priority patent/SV2002000245A/es
Priority to MYPI20006170A priority patent/MY140488A/en
Priority to CO00097415A priority patent/CO5251440A1/es
Priority to PE2000001388A priority patent/PE20010963A1/es
Publication of DE19962924A1 publication Critical patent/DE19962924A1/de
Priority to ZA200204188A priority patent/ZA200204188B/en
Priority to CU20020114A priority patent/CU23208A3/es
Priority to BG106825A priority patent/BG65683B1/bg
Priority to NO20023043A priority patent/NO323699B1/no
Priority to MA26708A priority patent/MA25646A1/fr
Priority to HR20020617A priority patent/HRP20020617B1/xx
Priority to HK04100440A priority patent/HK1057556A1/xx
Priority to HK06112529.9A priority patent/HK1092140A1/xx
Priority to CU20040221A priority patent/CU23423B7/es
Priority to AU2004218729A priority patent/AU2004218729A1/en
Priority to JP2004358908A priority patent/JP5190173B2/ja
Priority to HRP20060251AA priority patent/HRP20060251B1/hr
Priority to US11/460,529 priority patent/US7592339B2/en
Priority to NO20070981A priority patent/NO20070981L/no
Priority to HK07107638.6A priority patent/HK1103235A1/xx
Priority to US11/932,082 priority patent/US7576111B2/en
Priority to DO2008000001A priority patent/DOP2008000001A/es
Priority to US12/027,553 priority patent/US7585860B2/en
Priority to LU91497C priority patent/LU91497I2/xx
Priority to NL300370C priority patent/NL300370I2/nl
Priority to CY200800019C priority patent/CY2008019I1/el
Priority to LTPA2008018C priority patent/LTC1261606I2/lt
Priority to BE2008C046C priority patent/BE2008C046I2/fr
Priority to FR08C0051C priority patent/FR08C0051I2/fr
Priority to NO2009001C priority patent/NO2009001I1/no
Priority to US12/494,879 priority patent/US8129378B2/en
Priority to IL205242A priority patent/IL205242A/en
Priority to US13/360,107 priority patent/US8530505B2/en
Priority to UY0001034152A priority patent/UY34152A/es
Priority to US13/961,264 priority patent/US8822458B2/en
Priority to CY20141100383T priority patent/CY1115117T1/el
Priority to US14/336,379 priority patent/US20150166568A1/en
Priority to NO2021009C priority patent/NO2021009I1/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
DE19962924A 1999-12-24 1999-12-24 Substituierte Oxazolidinone und ihre Verwendung Withdrawn DE19962924A1 (de)

Priority Applications (84)

Application Number Priority Date Filing Date Title
DE19962924A DE19962924A1 (de) 1999-12-24 1999-12-24 Substituierte Oxazolidinone und ihre Verwendung
HN2000000267A HN2000000267A (es) 1999-12-24 2000-11-29 Oxazolidinonas substituidas y su uso
BRPI0017050-0A BR0017050B1 (pt) 1999-12-24 2000-12-11 oxazolidinonas substituÍdas, processo para sua produÇço, uso das mesmas e processo para impedir a coagulaÇço de sangue in vitro.
CA002396561A CA2396561C (en) 1999-12-24 2000-12-11 Substituted oxazolidinones and their use in the field of blood coagulation
HU0203902A HU226522B1 (en) 1999-12-24 2000-12-11 Substituted oxazolidinones, process for their preparation and pharmaceutical compositions containing them their use
AT00993610T ATE289605T1 (de) 1999-12-24 2000-12-11 Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung
TR2002/01636T TR200201636T2 (tr) 1999-12-24 2000-12-11 Sübstitüe edilmiş oksazolidinonlar ve bunların kullanımı
DE122009000014C DE122009000014I1 (de) 1999-12-24 2000-12-11 Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung
SG200403830-3A SG130939A1 (en) 1999-12-24 2000-12-11 Substituted oxazolidinones and their use in the field of blood coagulation
PT00993610T PT1261606E (pt) 1999-12-24 2000-12-11 Oxazolidinonas substituidas e a sua utilizacao na area da coagulacao sanguinea
SK908-2002A SK287272B6 (sk) 1999-12-24 2000-12-11 Substituované oxazolidinóny, spôsob ich výroby, lieky tieto látky obsahujúce a ich použitie
NZ519730A NZ519730A (en) 1999-12-24 2000-12-11 Substituted oxazolidinones and their use in the field of blood coagulation and preparation process thereof
CN2006100819193A CN1900074B (zh) 1999-12-24 2000-12-11 取代的*唑烷酮和其在血液凝固领域中的应用
EEP200200341A EE05169B1 (et) 1999-12-24 2000-12-11 Asendatud oksasolidinoonid ja nende kasutamine
ES04027037.3T ES2457021T3 (es) 1999-12-24 2000-12-11 Oxazolidinonas sustituidas y su uso como inhibidor del factor Xa
PT40270373T PT1526132E (pt) 1999-12-24 2000-12-11 Derivados de oxazolidinona substituídos e sua utilização enquanto inibidores do factor xa
AU28414/01A AU775126C (en) 1999-12-24 2000-12-11 Substituted oxazolidinones and their use in the field of blood coagulation
DK00993610T DK1261606T3 (da) 1999-12-24 2000-12-11 Substituerede oxazolidinoner og deres anvendelse inden for blodkoagulationsområdet
DE50009607T DE50009607D1 (de) 1999-12-24 2000-12-11 Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung
DK04027037.3T DK1526132T3 (da) 1999-12-24 2000-12-11 Substituerede oxazolidinoner og deres anvendelse som faktor Xa-hæmmer
PL382243A PL201121B1 (pl) 1999-12-24 2000-12-11 Podstawione oksazolidynony, sposób ich wytwarzania, środki lecznicze je zawierające oraz ich zastosowanie
EP04027037.3A EP1526132B1 (de) 1999-12-24 2000-12-11 Substituierte Oxazolidinone und ihre Verwendung als Faktor Xa Hemmer
CZ20022202A CZ301432B6 (cs) 1999-12-24 2000-12-11 Substituované oxazolidinony, zpusob jejich výroby, léciva tyto látky obsahující a jejich použití v oblasti srážení krve
KR1020027008172A KR100804932B1 (ko) 1999-12-24 2000-12-11 치환된 옥사졸리디논 및 혈액 응고 분야에서의 그의 용도
PL355665A PL200413B1 (pl) 1999-12-24 2000-12-11 Podstawione oksazolidynony, sposób ich wytwarzania, środki lecznicze je zawierające oraz ich zastosowanie do wytwarzania środków leczniczych i do zapobiegania krzepnięciu krwi ex vivo
CNB2005101271139A CN100549008C (zh) 1999-12-24 2000-12-11 取代的唑烷酮和其在血液凝固领域中的应用
TR2004/01314T TR200401314T2 (tr) 1999-12-24 2000-12-11 Sübstitüe edilmiş oksazolidinonlar ve bunların kullanımı
IL14989600A IL149896A0 (en) 1999-12-24 2000-12-11 Substituted oxazolidinones and their use in the field of blood coagulation
SI200030679T SI1261606T1 (US07585860-20090908-C00102.png) 1999-12-24 2000-12-11
RU2002120456/04A RU2297415C2 (ru) 1999-12-24 2000-12-11 Замещенные оксазолидиноны, способы их получения, лекарственное средство на их основе и применение замещенных оксазолидинонов
NZ537058A NZ537058A (en) 1999-12-24 2000-12-11 Substituted oxazolidinones and their use in the field of blood coagulation and preparation process thereof
US10/181,051 US7157456B2 (en) 1999-12-24 2000-12-11 Substituted oxazolidinones and their use in the field of blood coagulation
KR1020077008192A KR20070044075A (ko) 1999-12-24 2000-12-11 치환된 옥사졸리디논 및 혈액 응고 분야에서의 그의 용도
MXPA02006241A MXPA02006241A (es) 1999-12-24 2000-12-11 Oxazolidinonas sustituidas y su uso en el campo de la coagulacion sanguinea.
ES00993610T ES2237497T3 (es) 1999-12-24 2000-12-11 Oxazolidinonas substituidas y su uso en el campo de la coagulacion sanguinea.
SI200031079T SI1526132T1 (sl) 1999-12-24 2000-12-11 Substituirani derivati oksazolidinona in njihova uporaba kot inhibitorji faktorja Xa
PCT/EP2000/012492 WO2001047919A1 (de) 1999-12-24 2000-12-11 Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung
JP2001549389A JP4143297B2 (ja) 1999-12-24 2000-12-11 置換オキサゾリジノン及び血液凝固の分野におけるそれらの使用
CNB008189668A CN1262551C (zh) 1999-12-24 2000-12-11 取代的噁唑烷酮和其在血液凝固领域中的应用
EP00993610A EP1261606B1 (de) 1999-12-24 2000-12-11 Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung
KR1020077020537A KR20070094672A (ko) 1999-12-24 2000-12-11 치환된 옥사졸리디논 및 혈액 응고 분야에서의 그의 용도
UA2002076161A UA73339C2 (en) 1999-12-24 2000-12-11 Substituted oxazolidinones and use thereof for the prevention of blood coagulation
ARP000106733A AR032436A1 (es) 1999-12-24 2000-12-18 Oxazolidinonas substituidas, procedimiento para su preparacion, medicamentos, el uso de las mismas para la fabricacion de medicamentos, y el metodo para impedir la coagulacion sanguinea in vitro
GT200000216A GT200000216A (es) 1999-12-24 2000-12-19 Oxazolidinonas sustituidas y su uso.
DO2000000114A DOP2000000114A (es) 1999-12-24 2000-12-20 Oxazolidinonas substituidas y su uso
TW083120747A TWI277615B (de) 1999-12-24 2000-12-20 Substituted oxazolidinones and their use
TW089127307A TWI226330B (en) 1999-12-24 2000-12-20 Substituted oxazolidnones and their use
SV2000000245A SV2002000245A (es) 1999-12-24 2000-12-21 Oxazolidinonas substituidas y su uso ref. lea 34122-sv
MYPI20006170A MY140488A (en) 1999-12-24 2000-12-22 Substituted oxazolidinones and their use in the field of blood coagulation
CO00097415A CO5251440A1 (es) 1999-12-24 2000-12-22 Derivados de heterociclil-fenil-oxazolidin-tiofencarboxamida, su procedimiento de obtencion y medicamentos que los contienen
PE2000001388A PE20010963A1 (es) 1999-12-24 2000-12-22 OXAZOLIDINONAS SUSTITUIDAS COMO INHIBIDORES DEL FACTOR DE COAGULACION Xa
ZA200204188A ZA200204188B (en) 1999-12-24 2002-05-27 Substituted oxazolidinones and their use in the field of blood coagulaton.
CU20020114A CU23208A3 (es) 1999-12-24 2002-06-07 Oxazolidinonas sustituidas y su uso en el campo de la coagulacion sanguinea
BG106825A BG65683B1 (bg) 1999-12-24 2002-06-14 Заместени оксазолидинони и тяхното приложение в областта на кръвосъсирването
NO20023043A NO323699B1 (no) 1999-12-24 2002-06-21 Substituerte oksazolidinoner, fremgangsmate for fremstilling derav og deres anvendelse innenfor feltet blodkoagulasjon
MA26708A MA25646A1 (fr) 1999-12-24 2002-06-21 Oxazolidinones substitues et leur utilisation dans le domaine de la coagulation sanguine.
HR20020617A HRP20020617B1 (en) 1999-12-24 2002-07-23 Substituted oxazolidinones and ther use in the field of blood coagulation
HK04100440A HK1057556A1 (en) 1999-12-24 2004-01-20 Substituted oxazolidinones and their use in the field of blood coagulation
HK06112529.9A HK1092140A1 (en) 1999-12-24 2004-01-20 Substituted oxazolidinones and their use in the field of blood coagulation
CU20040221A CU23423B7 (es) 1999-12-24 2004-10-13 Oxazolidinonas sustituidas y su uso en el campo de la coagulación sanguínea
AU2004218729A AU2004218729A1 (en) 1999-12-24 2004-10-13 Substituted oxazolidinones and their use in the field of blood coagulation
JP2004358908A JP5190173B2 (ja) 1999-12-24 2004-12-10 置換オキサゾリジノン及び血液凝固の分野におけるそれらの使用
HRP20060251AA HRP20060251B1 (hr) 1999-12-24 2006-07-18 Supstituirani oksazolidinoni i njihova uporaba
US11/460,529 US7592339B2 (en) 1999-12-24 2006-07-27 Substituted oxazolidinones and their use in the field of blood coagulation
NO20070981A NO20070981L (no) 1999-12-24 2007-02-20 Substituerte oksazolidinoner og deres anvendelse innenfor feltet blodkoagulasjon.
HK07107638.6A HK1103235A1 (en) 1999-12-24 2007-07-17 Substuted oxazolidinones and their use in the field of blood coagulaton abstract
US11/932,082 US7576111B2 (en) 1999-12-24 2007-10-31 Substituted oxazolidinones and their use in the field of blood coagulation
DO2008000001A DOP2008000001A (es) 1999-12-24 2008-01-11 Oxazolidinonas substituidas y su uso
US12/027,553 US7585860B2 (en) 1999-12-24 2008-02-07 Substituted oxazolidinones and their use in the field of blood coagulation
LU91497C LU91497I2 (fr) 1999-12-24 2008-11-19 Rivaroxaban et ses sels pharmaceutiquement acceptables,hydrates,hydrates de ces sels et promédicaments
NL300370C NL300370I2 (nl) 1999-12-24 2008-11-25 Gesubstitueerde oxazolidinonen en toepassing daarvan op het terrein van Rivaroxaban, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, hydraat of hydraat van het zout
CY200800019C CY2008019I1 (el) 1999-12-24 2008-12-02 Υποκατεστημενες οξαζολιδινονες και η χρηση των στο πεδιο της πηξης αιματος
LTPA2008018C LTC1261606I2 (lt) 1999-12-24 2008-12-04 Pakeisti oksazolidinonai ir jų panaudojimas kraujo krešėjimo srityje
BE2008C046C BE2008C046I2 (US07585860-20090908-C00102.png) 1999-12-24 2008-12-10
FR08C0051C FR08C0051I2 (fr) 1999-12-24 2008-12-11 Oxazolidinones substituees et leur utilisation dans le domaine de la coagulation sanguine
NO2009001C NO2009001I1 (no) 1999-12-24 2009-01-08 Rivaroksaban
US12/494,879 US8129378B2 (en) 1999-12-24 2009-06-30 Substituted oxazolidinones and their use in the field of blood coagulation
IL205242A IL205242A (en) 1999-12-24 2010-04-22 Transduced oxazolidinones and their use in the field of blood clotting
US13/360,107 US8530505B2 (en) 1999-12-24 2012-01-27 Substituted oxazolidinones and their use in the field of blood coagulation
UY0001034152A UY34152A (es) 1999-12-24 2012-06-22 ?oxazolidinonas substituidas y su uso?.
US13/961,264 US8822458B2 (en) 1999-12-24 2013-08-07 Substituted oxazolidinones and their use in the field of blood coagulation
CY20141100383T CY1115117T1 (el) 1999-12-24 2014-05-29 Παραγωγα υποκατεστημενων οξαζολιδινονων και η χρηση τους ως αναστολεις παραγοντα χα
US14/336,379 US20150166568A1 (en) 1999-12-24 2014-07-21 Substituted oxazolidinones and their use in the field of blood coagulation
NO2021009C NO2021009I1 (no) 1999-12-24 2021-02-25 XARELTO - forlenget SPC

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19962924A DE19962924A1 (de) 1999-12-24 1999-12-24 Substituierte Oxazolidinone und ihre Verwendung

Publications (1)

Publication Number Publication Date
DE19962924A1 true DE19962924A1 (de) 2001-07-05

Family

ID=7934434

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19962924A Withdrawn DE19962924A1 (de) 1999-12-24 1999-12-24 Substituierte Oxazolidinone und ihre Verwendung
DE122009000014C Pending DE122009000014I1 (de) 1999-12-24 2000-12-11 Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung
DE50009607T Expired - Lifetime DE50009607D1 (de) 1999-12-24 2000-12-11 Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE122009000014C Pending DE122009000014I1 (de) 1999-12-24 2000-12-11 Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung
DE50009607T Expired - Lifetime DE50009607D1 (de) 1999-12-24 2000-12-11 Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung

Country Status (50)

Country Link
US (8) US7157456B2 (US07585860-20090908-C00102.png)
EP (2) EP1261606B1 (US07585860-20090908-C00102.png)
JP (2) JP4143297B2 (US07585860-20090908-C00102.png)
KR (3) KR20070044075A (US07585860-20090908-C00102.png)
CN (3) CN1262551C (US07585860-20090908-C00102.png)
AR (1) AR032436A1 (US07585860-20090908-C00102.png)
AT (1) ATE289605T1 (US07585860-20090908-C00102.png)
AU (2) AU775126C (US07585860-20090908-C00102.png)
BE (1) BE2008C046I2 (US07585860-20090908-C00102.png)
BG (1) BG65683B1 (US07585860-20090908-C00102.png)
BR (1) BR0017050B1 (US07585860-20090908-C00102.png)
CA (1) CA2396561C (US07585860-20090908-C00102.png)
CO (1) CO5251440A1 (US07585860-20090908-C00102.png)
CU (2) CU23208A3 (US07585860-20090908-C00102.png)
CY (2) CY2008019I1 (US07585860-20090908-C00102.png)
CZ (1) CZ301432B6 (US07585860-20090908-C00102.png)
DE (3) DE19962924A1 (US07585860-20090908-C00102.png)
DK (2) DK1526132T3 (US07585860-20090908-C00102.png)
DO (2) DOP2000000114A (US07585860-20090908-C00102.png)
EE (1) EE05169B1 (US07585860-20090908-C00102.png)
ES (2) ES2237497T3 (US07585860-20090908-C00102.png)
FR (1) FR08C0051I2 (US07585860-20090908-C00102.png)
GT (1) GT200000216A (US07585860-20090908-C00102.png)
HK (3) HK1057556A1 (US07585860-20090908-C00102.png)
HN (1) HN2000000267A (US07585860-20090908-C00102.png)
HR (2) HRP20020617B1 (US07585860-20090908-C00102.png)
HU (1) HU226522B1 (US07585860-20090908-C00102.png)
IL (2) IL149896A0 (US07585860-20090908-C00102.png)
LT (1) LTC1261606I2 (US07585860-20090908-C00102.png)
LU (1) LU91497I2 (US07585860-20090908-C00102.png)
MA (1) MA25646A1 (US07585860-20090908-C00102.png)
MX (1) MXPA02006241A (US07585860-20090908-C00102.png)
MY (1) MY140488A (US07585860-20090908-C00102.png)
NL (1) NL300370I2 (US07585860-20090908-C00102.png)
NO (4) NO323699B1 (US07585860-20090908-C00102.png)
NZ (2) NZ519730A (US07585860-20090908-C00102.png)
PE (1) PE20010963A1 (US07585860-20090908-C00102.png)
PL (2) PL200413B1 (US07585860-20090908-C00102.png)
PT (2) PT1261606E (US07585860-20090908-C00102.png)
RU (1) RU2297415C2 (US07585860-20090908-C00102.png)
SG (1) SG130939A1 (US07585860-20090908-C00102.png)
SI (2) SI1526132T1 (US07585860-20090908-C00102.png)
SK (1) SK287272B6 (US07585860-20090908-C00102.png)
SV (1) SV2002000245A (US07585860-20090908-C00102.png)
TR (2) TR200401314T2 (US07585860-20090908-C00102.png)
TW (2) TWI226330B (US07585860-20090908-C00102.png)
UA (1) UA73339C2 (US07585860-20090908-C00102.png)
UY (1) UY34152A (US07585860-20090908-C00102.png)
WO (1) WO2001047919A1 (US07585860-20090908-C00102.png)
ZA (1) ZA200204188B (US07585860-20090908-C00102.png)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
US7576111B2 (en) 1999-12-24 2009-08-18 Bayer Schering Pharma Ag Substituted oxazolidinones and their use in the field of blood coagulation
US7767702B2 (en) * 2001-06-20 2010-08-03 Bayer Schering Pharma Aktiengesellschaft Substituted oxazolidinones for combinational therapy
US7932278B2 (en) 2005-09-23 2011-04-26 Bayer Schering Pharma Aktiengesellschaft 2-aminoethoxyacetic acid derivatives and their use
US8106192B2 (en) 2003-01-07 2012-01-31 Bayer Pharma Aktiengesellschaft Method for producing 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide
WO2012041263A2 (en) 2010-09-30 2012-04-05 Farmak, A.S. A method of manufacturing 2-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]- l,3-oxazolidin-5-yl}methyl)-lh-isoindol-l,3(2h)-dione with a high optical purity
US8188270B2 (en) 2005-10-04 2012-05-29 Bayer Schering Pharma Aktiengesellschaft Polymorphous form of 5-chloro-N-({(5S)-2-oxo-3[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide
US8586082B2 (en) 2005-10-04 2013-11-19 Bayer Intellectual Property Gmbh Solid orally administerable pharmaceutical dosage forms with rapid active principle release
US9402851B2 (en) 2003-11-27 2016-08-02 Bayer Intellectual Property Gmbh Process for the preparation of a solid, orally administrable pharmaceutical composition
US9539218B2 (en) 2005-01-31 2017-01-10 Bayer Intellectual Property Gmbh Prevention and treatment of thromboembolic disorders

Families Citing this family (236)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710058B2 (en) * 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
DE10105989A1 (de) 2001-02-09 2002-08-14 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
CA2464109A1 (en) * 2001-10-18 2003-12-24 Michigan State University Process for the preparation of oxazolidinones and method of use thereof
DE10152460A1 (de) * 2001-10-24 2003-05-08 Bayer Ag Stents
CA2477604A1 (en) 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
US7012088B2 (en) 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
DE10322469A1 (de) * 2003-05-19 2004-12-16 Bayer Healthcare Ag Heterocyclische Verbindungen
DE10336716A1 (de) * 2003-08-11 2005-03-10 Merck Patent Gmbh Verfahren zur Herstellung von N-Aryl-morpholinonen
DE10342570A1 (de) * 2003-09-15 2005-04-14 Bayer Healthcare Ag Verfahren zur Herstellung von 4-(4-Aminophenyl)-3-morpholinon
DE102004002044A1 (de) * 2004-01-15 2005-08-04 Bayer Healthcare Ag Herstellverfahren
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
EP1571154A1 (en) * 2004-03-03 2005-09-07 Aventis Pharma Deutschland GmbH Beta-aminoacid-derivatives as factor Xa inhibitors
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
RU2006143842A (ru) 2004-05-13 2008-08-20 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые замещенные тиофенкарбоксамиды, их получение и их применение в качестве лекарственных средств
CA2562714A1 (en) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Substituted thiophene-2-carboxylic acid amides, the production thereof and the use thereof as drugs
US7521470B2 (en) * 2004-06-18 2009-04-21 Millennium Pharmaceuticals, Inc. Factor Xa inhibitors
US7696352B2 (en) * 2004-06-18 2010-04-13 Millennium Pharmaceuticals, Inc. Factor Xa inhibitors
PL1768967T3 (pl) * 2004-07-20 2009-09-30 Symed Labs Ltd Nowe związki pośrednie do wytwarzania linezolidu oraz związki pokrewne
PE20060619A1 (es) 2004-07-29 2006-07-11 Ferrer Int Derivados de oxazolidinona como antibacterianos
DE102004047840A1 (de) 2004-09-29 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
DE102004050283A1 (de) * 2004-10-15 2006-04-27 Lanxess Deutschland Gmbh 4-Aminophenyl-morpholinon-Derivate und deren Herstellung
US7662837B2 (en) 2004-10-22 2010-02-16 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
US7645755B2 (en) 2004-10-22 2010-01-12 Janssen Pharmaceutical N.V. Inhibitors of c-fms kinase
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
DE602006020327D1 (de) 2005-01-19 2011-04-07 Bristol Myers Squibb Co 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-aminder-hemmer zur behandlung thromboembolischer erkrankungen
CA2601777A1 (en) * 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
DE102005018690A1 (de) * 2005-04-22 2006-10-26 Bayer Healthcare Ag Imino-oxazolidine und ihre Verwendung
US20060281788A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
ATE485269T1 (de) 2005-06-27 2010-11-15 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden
WO2007002637A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
US7816382B2 (en) 2005-06-27 2010-10-19 Bristol-Myers Squibb Company Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition
US7714002B2 (en) 2005-06-27 2010-05-11 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
PE20070171A1 (es) * 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
WO2007007588A1 (ja) * 2005-07-08 2007-01-18 Ono Pharmaceutical Co., Ltd. 平面性を有する環状基を母核とする化合物
US20070032473A1 (en) * 2005-07-19 2007-02-08 Kai Gerlach Substituted amides and their use as medicaments
AR057976A1 (es) * 2005-08-29 2008-01-09 Boehringer Ingelheim Int Biarilos sustituidos y su uso como medicamentos.
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005047564A1 (de) * 2005-10-04 2007-05-31 Bayer Healthcare Ag Amorphe Form von 5-Chlor-N-({(5S)2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl)-methyl)-2-thiophencarboxamid
DE102005048824A1 (de) * 2005-10-10 2007-04-12 Bayer Healthcare Ag Behandlung und Prophylaxe von Mikroangiopathien
UA94719C2 (ru) 2005-10-18 2011-06-10 Янссен Фармацевтика Н.В. Применение производного имидазол-2-карбоновой кислоты для лечения или профилактики гематологической злокачественной опухоли
US7962847B2 (en) * 2005-10-20 2011-06-14 International Business Machines Corporation Method for providing dynamic process step annotations
DE102005052174A1 (de) 2005-11-02 2007-06-06 Bayer Healthcare Ag Phenylen-bis-oxazolidin-Derivate und ihre Verwendung
JP2007154330A (ja) * 2005-12-01 2007-06-21 Nippon Paper Industries Co Ltd 印刷用塗工紙
RU2513107C2 (ru) * 2005-12-30 2014-04-20 Мерк Шарп И Доум Корп. Ингибиторы сетр
DE102006007146A1 (de) 2006-02-16 2007-08-23 Bayer Healthcare Ag Aminoacyl-Prodrugs
EP2181993A1 (en) 2006-03-31 2010-05-05 Research Foundation Itsuu Laboratory Antimicrobial oxazolidinone derivatives
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
EP2021329B1 (en) 2006-04-20 2016-04-13 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
ES2458291T3 (es) 2006-04-20 2014-04-30 Janssen Pharmaceutica Nv Derivados de amidas aromáticas como inhibidores de la cinasa C-KIT
EP2016074B1 (en) 2006-04-20 2016-01-13 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
SI2021335T1 (sl) * 2006-04-20 2011-09-30 Janssen Pharmaceutica Nv Heterocikliäśne spojine kot zaviralci c-fms kinaze
JP5227311B2 (ja) 2006-05-05 2013-07-03 ミレニアム ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子阻害剤
DE102006025314A1 (de) * 2006-05-31 2007-12-06 Bayer Healthcare Ag Arylsubstituierte Heterozyklen und ihre Verwendung
DE102006025319A1 (de) * 2006-05-31 2007-12-06 Bayer Healthcare Aktiengesellschaft Substituierte Heterozyklen und ihre Verwendung
DE102006034916A1 (de) * 2006-07-28 2008-01-31 Bayer Healthcare Ag Beschichtung künstlicher Oberflächen von medizinischen Hilfsmitteln und Geräten sowie Reinigung und/oder Vorbehandlung von Kathetern und anderen medizinischen Hilfsmitteln und Geräten
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
DE102006051625A1 (de) * 2006-11-02 2008-05-08 Bayer Materialscience Ag Kombinationstherapie substituierter Oxazolidinone
CN101605779B (zh) 2006-12-15 2013-11-20 百时美施贵宝公司 作为凝血因子xia抑制剂的芳基丙酰胺、芳基丙烯酰胺、芳基丙炔酰胺或芳基甲基脲类似物
PE20081775A1 (es) 2006-12-20 2008-12-18 Bristol Myers Squibb Co Compuestos macrociclicos como inhibidores del factor viia
JP2010515691A (ja) * 2007-01-05 2010-05-13 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 第Ｘａ因子阻害剤
US7998992B2 (en) 2007-03-30 2011-08-16 Institute Of Medicinal Molecular Design, Inc. Oxazolidinone derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1
DE102007018662A1 (de) * 2007-04-20 2008-10-23 Bayer Healthcare Ag Oxazolidinone zur Behandlung und Prophylaxe von pulmonaler Hypertonie
WO2008128647A1 (en) 2007-04-23 2008-10-30 Sanofi-Aventis Quinoline-carboxamide derivatives as p2y12 antagonists
KR101009594B1 (ko) 2007-05-09 2011-01-20 주식회사 레고켐 바이오사이언스 Ｐ4 위치에 사이클릭 아미딘을 가지는 ＦＸａ 저해제, 이의유도체, 제조방법 및 이를 함유하는 의약 조성물
WO2008140220A1 (en) * 2007-05-09 2008-11-20 Legochem Bioscience Ltd. Fxa inhibitors with cyclic amidines as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
DE102007028406A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028318A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Oxazolidinone zur Behandlung und Prophylaxe von Sepsis
DE102007028319A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028407A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028320A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
WO2009018807A1 (de) * 2007-08-06 2009-02-12 Schebo Biotech Ag Oxazolidinone als faktor xa- inhibitoren, verfahren zu ihrer herstellung und ihre verwendung in der therapie
DE102007037373A1 (de) 2007-08-06 2009-02-19 Schebo Biotech Ag Neue Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Therapie
US20090076264A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched rivaroxaban
WO2009044777A1 (ja) 2007-10-02 2009-04-09 Research Foundation Itsuu Laboratory ７員ヘテロ環を有するオキサゾリジノン誘導体
JO3240B1 (ar) 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
WO2009063028A2 (en) * 2007-11-15 2009-05-22 Boehringer Ingelheim International Gmbh Substituted amides, manufacturing and use thereof as medicaments
JP2011506363A (ja) * 2007-12-11 2011-03-03 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト 心不全の処置および／または予防用のオキサゾリジノン類
JP5504171B2 (ja) 2007-12-26 2014-05-28 サノフイ Ｐ２ｙ１２アンタゴニストとしてのヘテロサイクリックピラゾール−カルボキサミド
AU2009239430B2 (en) 2008-04-21 2015-01-22 Signum Biosciences, Inc. Compounds, compositions and methods for making the same
DE102008028071A1 (de) 2008-06-12 2009-12-17 Bayer Schering Pharma Aktiengesellschaft Neue Cokristall-Verbindung von Rivaroxaban und Malonsäure
EP2138178A1 (en) 2008-06-28 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma
KR100898361B1 (ko) * 2008-07-03 2009-05-20 주식회사 레고켐 바이오사이언스 Ｐ4 위치에 사이클릭 아미독심 또는 사이클릭 아미드라존기를 가지는 ＦＸａ 저해제, 이의 유도체, 제조방법 및이를 함유하는 의약 조성물
EP2140866A1 (en) * 2008-07-04 2010-01-06 Bayer Schering Pharma Aktiengesellschaft Oxazolidinones for the treatment of inflammatory conditions of the gastrointestinal tract
RU2011104360A (ru) 2008-07-08 2012-08-20 Рациофарм ГмбХ (DE) Фармацевтические соединения, содержащие 5-хлор-n-({(5s)-2-оксо-3-[4-(3-оксо-4-морфолинил)-фенил]-1,3-оксазолидин-5-ил}-митил)-2-тиофенкарбоксамид
KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
US20100168111A1 (en) * 2008-12-31 2010-07-01 Apotex Pharmachem Inc. Polymorphic form of 5 chloro n {[(5s) 2 oxo 3 [4 (3 oxomorpholin 4 yl)phenyl]oxa-zolidin 5 yl]-methyl}thiophene 2 carboxamide
PE20120003A1 (es) * 2009-01-30 2012-02-12 Glaxosmithkline Llc Hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil)etil}-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino
US7816355B1 (en) * 2009-04-28 2010-10-19 Apotex Pharmachem Inc Processes for the preparation of rivaroxaban and intermediates thereof
HUE031177T2 (hu) 2009-06-18 2017-07-28 Krka Tovarna Zdravil D D Novo Mesto Rivaroxabant tartalmazó szilárd gyógyszerkészítmény
EP2266541A1 (en) 2009-06-18 2010-12-29 Krka Tovarna Zdravil, D.D., Novo Mesto Solid pharmaceutical composition comprising rivaroxaban
KR101037051B1 (ko) 2009-07-08 2011-05-26 주식회사 레고켐 바이오사이언스 (ｓ)-5-클로로-ｎ-((3-(4-(5,6-다이하이드로-4ｈ-1,2,4-옥사다이아진-3-일)페닐)-2-옥소옥사졸리딘-5-일)메틸)싸이오펜-2-카르복사미드 유도체의 제조방법
KR101037052B1 (ko) * 2009-07-08 2011-05-26 주식회사 레고켐 바이오사이언스 5-클로로-ｎ-(((5ｓ)-2-옥소-3-(4-(5,6-디하이드로-1,2,4-트리아진-1(4ｈ)-일)페닐)-1,3-옥사졸리딘-5-일)메틸)티오펜-2-카르복사미드 유도체의 제조방법 및 그 제조중간체
WO2011012321A1 (en) 2009-07-31 2011-02-03 Krka, D.D., Novo Mesto Processes for crystallization of rivaroxaban
US20120231076A1 (en) 2009-10-06 2012-09-13 Ratiopharm Gmbh Pharmaceutical compositions comprising rivaroxaban
EP2308472A1 (en) 2009-10-06 2011-04-13 ratiopharm GmbH Pharmaceutical compositions comprising rivaroxaban
WO2011061760A1 (en) * 2009-11-18 2011-05-26 Cadila Healthcare Limited Novel antithrombotic agents
US8742120B2 (en) * 2009-12-17 2014-06-03 Millennium Pharmaceuticals, Inc. Methods of preparing factor xa inhibitors and salts thereof
JP5796872B2 (ja) 2009-12-17 2015-10-21 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 第Ｘａ因子阻害剤の結晶性塩
CN102822167A (zh) * 2010-01-04 2012-12-12 埃南蒂亚有限公司 用于制备利伐沙班的方法及其中间体
EA015918B1 (ru) 2010-03-03 2011-12-30 Дмитрий Геннадьевич ТОВБИН УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
EP2354128A1 (en) * 2010-02-10 2011-08-10 Sandoz Ag Method for the preparation of rivaroxaban
US8940720B2 (en) 2010-02-11 2015-01-27 Bristol-Myers Squibb Company Macrocycles as factor XIa inhibitors
DE102010018299A1 (de) 2010-04-23 2011-10-27 Archimica Gmbh Verfahren zur Herstellung von 4-(4-Aminophenyl)-morpholin-3-on
DE102010028362A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Herstellverfahren
KR101799429B1 (ko) * 2010-05-03 2017-11-21 에스케이바이오팜 주식회사 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물
EP2388260A1 (de) 2010-05-21 2011-11-23 Archimica GmbH Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors
CN107021932A (zh) * 2010-06-29 2017-08-08 欧美嘉股份有限公司 制备5‑左旋‑氨甲基‑3‑芳基‑2‑恶唑烷酮类的方法
EP2404920A1 (en) 2010-07-06 2012-01-11 Sandoz AG Crystalline form of Rivaroxaban dihydrate
US20130253187A1 (en) * 2010-09-14 2013-09-26 Medichem, S.A. Process for Determining the Suitability for Distribution of a Batch of Thiophene-2-Carboxamide Derivative
EP2630143B1 (en) * 2010-10-18 2017-11-29 Apotex Pharmachem Inc. Processes for the preparation of rivaroxaban and intermediates thereof
CN102464658B (zh) * 2010-11-03 2014-04-16 天津药物研究院 噁唑烷酮衍生物及其制备方法和用途
DE102010063127A1 (de) 2010-12-15 2012-06-21 Bayer Schering Pharma Aktiengesellschaft Flüssige, oral applizierbare pharmazeutische Zusammensetzungen enthaltend 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
WO2012098089A1 (en) 2011-01-19 2012-07-26 Bayer Pharma Aktiengesellschaft Binding proteins to inhibitors of coagulation factors
CN102199150A (zh) * 2011-04-01 2011-09-28 中国药科大学 光学活性噁唑烷酮类衍生物及其制备方法与在制药中的用途
EP2697209B1 (en) 2011-04-11 2015-09-23 Sandoz AG Method for the preparation of substituted oxazolidinones
MD4557C1 (ro) * 2011-05-06 2018-10-31 Egis Gyogysszegyar Nyilvanosan Mukodo Reszvenytarsasag Procedeu de obţinere a rivaroxabanului şi un compus intermediar utilizat în acest procedeu
WO2012156983A1 (en) * 2011-05-16 2012-11-22 Symed Labs Limited Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide
ES2395304B1 (es) * 2011-05-20 2014-01-16 Interquim, S.A. Procedimiento de obtención de una tiofen-2-carboxamida.
CN102796091A (zh) * 2011-05-24 2012-11-28 北大方正集团有限公司 取代的噁唑烷酮化合物及其制备方法和应用
CN102796092B (zh) * 2011-05-24 2015-04-08 北大方正集团有限公司 噁唑烷酮衍生物及其制备方法和应用
CN102320988B (zh) * 2011-06-03 2014-04-09 中国科学院上海有机化学研究所 4-(4-氨基苯基)-3-吗啉酮中间体酰胺、合成方法和用途
CN102827154B (zh) * 2011-06-14 2015-04-22 上海科胜药物研发有限公司 一种合成利伐沙班中间体4-{4-[(5s)-5-(氨基甲基)-2-氧代-1,3-恶唑烷-3-基]苯基}吗啉-3-酮的方法
TW201311689A (zh) 2011-08-05 2013-03-16 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之新穎巨環化合物
TW201319068A (zh) 2011-08-05 2013-05-16 必治妥美雅史谷比公司 作為ｘｉａ因子抑制劑之環狀ｐ１接合劑
EP2753619A2 (en) 2011-09-08 2014-07-16 Cadila Healthcare Limited Processes and intermediates for preparing rivaroxaban
EP2573084A1 (en) 2011-09-22 2013-03-27 Enantia, S.L. Novel crystalline forms of rivaroxaban and processes for their preparation
WO2013046211A1 (en) * 2011-09-27 2013-04-04 Symed Labs Limited Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
WO2013053739A1 (en) 2011-10-10 2013-04-18 Laboratorios Lesvi, S. L. Process for preparing factor xa inhibitors
HU230734B1 (hu) 2011-10-10 2017-12-28 EGIS Gyógyszergyár Nyrt Gyógyászati készítmény előállítására alkalmazható rivaroxaban kokristályok
EP2766373B1 (en) * 2011-10-11 2016-08-17 Council of Scientific & Industrial Research Sila analogs of oxazolidinone derivatives and synthesis thereof
ES2579832T3 (es) 2011-10-14 2016-08-17 Bristol-Myers Squibb Company Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa
HUE034857T2 (en) 2011-10-14 2018-03-28 Bristol Myers Squibb Co Substituted tetrahydroisoquinoline compounds are inhibitors of factor XIA
ES2699226T3 (es) 2011-10-14 2019-02-08 Bristol Myers Squibb Co Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIa
CN102408420B (zh) * 2011-10-19 2014-10-22 汕头经济特区鮀滨制药厂 一种利伐沙班及其中间体的制备方法以及中间体化合物
WO2013121436A2 (en) 2012-02-06 2013-08-22 Megafine Pharma (P) Ltd A process for preparation of rivaroxaban and intermediates thereof
CZ2012111A3 (cs) 2012-02-16 2013-08-28 Zentiva, K.S. Zpusob prípravy rivaroxabanu zalozený na vyuzití (S)-epichlorhydrinu
CZ2012114A3 (cs) 2012-02-17 2013-02-20 Zentiva, K.S. Zpusob prípravy rivaroxabanu zalozený na úspore 1,1´ -karbonyldiimidazolu
CN103288814B (zh) 2012-02-24 2016-07-06 国药集团国瑞药业有限公司 一种利伐沙班中间体的制备方法
WO2013151719A2 (en) * 2012-04-05 2013-10-10 Scifluor Life Sciences, Llc Fluorinated oxazolidinone derivatives
US9562040B2 (en) 2012-04-06 2017-02-07 Indiana University Research And Technology Corporation Processes for preparing Rivaroxaban
AU2013250801A1 (en) 2012-04-16 2014-11-06 Sun Pharmaceutical Industries Limited Process for the preparation of rivaroxaban and intermediates thereof
ES2871811T3 (es) * 2012-05-02 2021-11-02 Symed Labs Ltd Proceso mejorado para preparar rivaroxabán utilizando intermedios novedosos
SG11201407518SA (en) * 2012-05-24 2014-12-30 Ranbaxy Lab Ltd Process for the preparation of rivaroxaban
CN102746287B (zh) * 2012-06-21 2014-05-28 成都苑东药业有限公司 一种恶唑烷酮化合物及其制备方法
UY34856A (es) 2012-07-03 2013-12-31 Bayer Pharma AG Formas de presentación farmacéuticas que contienen 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4- morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofencarboxamida
CN102757424B (zh) * 2012-07-09 2014-10-15 云南大学 2-苄基取代苯并呋喃—咪唑盐类化合物及其制备方法
CN102746288B (zh) * 2012-07-24 2015-04-08 常州制药厂有限公司 一种抗凝血药及其关键中间体的制备方法
RS55581B1 (sr) 2012-08-03 2017-06-30 Bristol Myers Squibb Co Dihidropiridon kao inhibitor faktora xia
DK2880026T3 (en) 2012-08-03 2017-06-06 Bristol Myers Squibb Co DIHYDROPYRIDON-P1 AS A FACTOR XIA INHIBITORS
JOP20180012A1 (ar) 2012-08-07 2019-01-30 Janssen Pharmaceutica Nv عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
IN2015DN00659A (US07585860-20090908-C00102.png) 2012-08-07 2015-06-26 Janssen Pharmaceutica Nv
CN103626749A (zh) * 2012-08-21 2014-03-12 苏州泽璟生物制药有限公司 取代的噁唑烷酮化合物和包含该化合物的药物组合物及其用途
US20150218145A1 (en) 2012-09-26 2015-08-06 Ranbaxy Laboratories Limited Process for the preparation of rivaroxaban
CN103864773B (zh) * 2012-12-13 2017-03-15 北京藏卫信康医药研发有限公司 利伐沙班及其中间体的制备方法
WO2014096214A1 (en) * 2012-12-21 2014-06-26 Farma Grs, D.O.O. A process for preparation of rivaroxaban
HUE032850T2 (en) 2012-12-26 2017-11-28 Wanbury Ltd Rivaroxaban intermediate and its preparation
EP2897619A4 (en) * 2012-12-26 2016-08-17 Wanbury Ltd ALDEHYDE DERIVATIVE FROM SUBSTITUTED OXAZOLIDINONES
ES2712699T3 (es) 2013-03-25 2019-05-14 Bristol Myers Squibb Co Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa
US9663505B2 (en) 2013-03-25 2017-05-30 Glenmark Pharmaceuticals Limited Process for the preparation of rivaroxaban
CN104098556B (zh) * 2013-04-09 2019-01-08 浙江九洲药物科技有限公司 一种利伐沙班的合成工艺
CN103242307B (zh) * 2013-05-17 2015-08-12 天津药物研究院有限公司 一种噁唑烷酮类衍生物晶型ⅰ及其制备方法和用途
CN104163819A (zh) * 2013-05-17 2014-11-26 天津药物研究院 一种噁唑烷酮衍生物的乙酸溶剂化物及其制备方法和用途
UY35592A (es) 2013-06-03 2014-12-31 Bayer Pharma AG Benzoxazoles sustituidos
CA2913958A1 (en) 2013-06-03 2014-12-11 Bayer Pharma Aktiengesellschaft Substituted benzoxazoles
EP3004095A1 (de) * 2013-06-03 2016-04-13 Bayer Pharma Aktiengesellschaft Triazolopyridine als thrombininhibitoren zur behandlung von thromboembolischen erkrankungen
WO2015011617A1 (en) 2013-07-23 2015-01-29 Ranbaxy Laboratories Limited Process for the preparation of rivaroxaban
WO2015026761A1 (en) * 2013-08-19 2015-02-26 Amneal Pharmaceuticals Llc A process for the preparation of rivaroxaban
IN2014MU00072A (US07585860-20090908-C00102.png) 2014-01-08 2015-08-21 Wockhardt Ltd
WO2015111076A2 (en) * 2014-01-23 2015-07-30 Symed Labs Limited Improved processes for the preparation of highly pure rivaroxaban crystal modification i
MY190429A (en) 2014-01-31 2022-04-21 Bristol Myers Squibb Co Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
NO2760821T3 (US07585860-20090908-C00102.png) 2014-01-31 2018-03-10
WO2015124995A1 (en) 2014-02-19 2015-08-27 Aurobindo Pharma Ltd Solid dosage forms of rivaroxaban
EP2929885A1 (en) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and proton pump inhibitors
CN104974149B (zh) * 2014-04-14 2018-05-01 北大方正集团有限公司 一种利伐沙班的制备方法
KR101499867B1 (ko) * 2014-04-22 2015-03-06 에스케이케미칼주식회사 활성 성분 (i) 함유 조성물 및 이의 제조 방법
CN105085370B (zh) * 2014-04-22 2017-04-12 北大方正集团有限公司 (s)‑1‑卤代‑2‑[2‑(1,3‑二氧异吲哚)基]乙基氯甲酸酯及其制备方法
CN105085371B (zh) * 2014-04-22 2017-06-16 北大方正集团有限公司 (s)‑{1‑(氯甲酸酯基)‑2‑[2‑(1,3‑二氧异吲哚)基]乙基}卤化盐及其制备方法
WO2015169957A1 (en) 2014-05-09 2015-11-12 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and h2-receptor antagonists
CN104031036A (zh) * 2014-05-16 2014-09-10 南通常佑药业科技有限公司 一种利伐沙班的制备方法
KR102412045B1 (ko) 2014-05-22 2022-06-22 놀스 차이나 파마수티칼 컴퍼니., 엘티디. 혈액응고인자 Xa 억제제로서의 히드라지드 화합물
CN103980221B (zh) * 2014-05-26 2016-03-23 山东康美乐医药科技有限公司 4-（硝基苯基）-3-吗啉酮的制备方法及利用其制备利伐沙班的方法
DE102014108210A1 (de) * 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
WO2015198259A1 (en) 2014-06-26 2015-12-30 Erregierre S.P.A. Process for the synthesis of rivaroxaban and intermediate for the production thereof
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
SI3169666T1 (en) 2014-07-15 2018-08-31 Gruenenthal Gmbh SUBSTITUTED DERIVATIVES AZASPIRO (4.5) DECAN
CN104086539A (zh) * 2014-07-17 2014-10-08 天津炜捷制药有限公司 一种利伐沙班的制备方法
US20170267669A1 (en) 2014-08-25 2017-09-21 Cipla Limited Process for the Preparation of Rivaroxaban
NO2721243T3 (US07585860-20090908-C00102.png) 2014-10-01 2018-10-20
CN104356124A (zh) * 2014-10-30 2015-02-18 广东东阳光药业有限公司 噁唑烷酮类化合物及其组合物和用途
CN104402876A (zh) * 2014-11-25 2015-03-11 沈阳药科大学 噁唑烷酮类化合物及其应用
CN104447729A (zh) * 2014-12-05 2015-03-25 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104447728B (zh) * 2014-12-05 2017-01-04 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104478869B (zh) * 2014-12-05 2017-04-12 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104478866B (zh) * 2014-12-05 2017-07-07 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途
CN104497008B (zh) * 2014-12-09 2016-11-16 广东东阳光药业有限公司 取代噁唑烷酮类化合物及其使用方法和用途
CN104496978A (zh) * 2014-12-09 2015-04-08 广东东阳光药业有限公司 取代噁唑烷酮类化合物及其使用方法和用途
CN104530031A (zh) * 2014-12-10 2015-04-22 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104530030A (zh) * 2014-12-10 2015-04-22 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104530080B (zh) * 2014-12-10 2017-01-11 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN105777734A (zh) * 2014-12-22 2016-07-20 常州方楠医药技术有限公司 一种利伐沙班中间体的合成方法
CN104557900A (zh) * 2014-12-23 2015-04-29 中国药科大学 噁唑烷酮类化合物及其制备方法与医药用途
CN105820161A (zh) * 2015-01-08 2016-08-03 常州方楠医药技术有限公司 一种利伐沙班中间体5-羟基甲基噁唑烷酮衍生物的合成方法
TR201501970A2 (en) 2015-02-19 2016-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical combinations of dronedarone.
CA2979113A1 (en) 2015-03-20 2016-09-29 F. Hoffmann-La Roche Ag Bace1 inhibitors
WO2016150937A1 (en) 2015-03-25 2016-09-29 Lonza Ltd Method for preparation of thiophenecarbonyl chlorides
CN104926807B (zh) * 2015-06-04 2017-10-31 沈阳药科大学 一种利伐沙班相关物质“二胺”及其合成方法
CN108026083B (zh) 2015-06-19 2021-08-27 百时美施贵宝公司 作为因子xia抑制剂的二酰胺大环
EP3328852B1 (en) 2015-07-29 2021-04-28 Bristol-Myers Squibb Company Factor xia macrocyclic inhibitors bearing a non-aromatic p2' group
US10336730B2 (en) 2015-08-05 2019-07-02 Bristol-Myers Squibb Company Substituted glycine derived FXIA inhibitors
WO2017076844A1 (en) * 2015-11-04 2017-05-11 Lonza Ltd Method for preparation of thiophene-2-carbonyl chlorides with oxalyl chloride
CA3010726A1 (en) 2016-02-23 2017-08-31 Morgandane Scientific, LLC Method of treating patients coadministered a factor xa inhibitor and verapamil
JP2019507167A (ja) 2016-03-02 2019-03-14 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 第ｘｉａ因子阻害活性を有するジアミド大員環
WO2018001914A1 (en) 2016-06-28 2018-01-04 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical capsule composition of rivaroxaban
CN106588905A (zh) * 2016-12-13 2017-04-26 重庆英斯凯化工有限公司 一种利伐沙班中间体的制备方法
ES2923932T3 (es) * 2017-01-04 2022-10-03 Unichem Lab Ltd Un procedimiento mejorado para la preparación de rivaroxabán que implica un intermedio novedoso
CN107586291B (zh) * 2017-11-03 2019-08-20 梯尔希（南京）药物研发有限公司 一种利伐沙班代谢物5的合成方法
CN107857739A (zh) * 2017-11-14 2018-03-30 安徽华胜医药科技有限公司 一种氘代利伐沙班关键中间体及其制备方法
CN107857761A (zh) * 2017-11-14 2018-03-30 安徽华胜医药科技有限公司 一种氘代利伐沙班及其制备方法
CN108164519A (zh) * 2017-12-28 2018-06-15 江苏悦兴医药技术有限公司 利伐沙班工艺杂质的合成方法
EP3505160A1 (en) 2017-12-31 2019-07-03 Abdi Ibrahim Ilac Sanayi ve Ticaret A.S. Preparation of a solid pharmaceutical composition comprising rivaroxaban and production thereof
HU231119B1 (hu) 2018-01-12 2020-11-30 Richter Gedeon Nyrt. Eljárás 4-(4-aminofenil)morfolin-3-on előállítására
US10828310B2 (en) 2018-02-02 2020-11-10 Bayer Pharma Aktiengesellschaft Reducing the risk of cardiovascular events
GB201807014D0 (en) 2018-04-30 2018-06-13 Univ Leeds Innovations Ltd Factor xlla inhibitors
CN108546265A (zh) * 2018-06-22 2018-09-18 苏州中联化学制药有限公司 一种利伐沙班中间体的合成方法
US10722486B2 (en) 2018-08-13 2020-07-28 Morgandane Scientific, LLC Method of treating patients with a factor Xa inhibitor, aspirin, and verapamil
CN110054621A (zh) * 2019-03-12 2019-07-26 浙江天宇药业股份有限公司 一种利伐沙班中间体的制备方法
CN110615756A (zh) * 2019-06-28 2019-12-27 南京红杉生物科技有限公司 1-(4-硝基苯基)哌啶-2-酮及其合成方法和应用
US11608320B2 (en) 2020-02-02 2023-03-21 Kuwait University Oxazolidinone hydroxamic acid derivatives
CN111253383A (zh) * 2020-03-27 2020-06-09 南京国星生物技术研究院有限公司 一种利伐沙班的合成方法
CN112159402B (zh) * 2020-10-28 2022-04-05 南京法恩化学有限公司 一种利伐沙班的制备方法
GB202102575D0 (en) 2021-02-23 2021-04-07 Teva Pharmaceutical Industries Ltd Fixed-dose pharmaceutical compositions
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide
GB202107722D0 (en) 2021-05-28 2021-07-14 Lunac Therapeutics Ltd Factor XIIA Inhibitors

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1035546B (de) 1955-02-16 1958-07-31 Max Ruf Torbegrenzung fuer Ballspiele
US2811555A (en) 1955-05-02 1957-10-29 Eastman Kodak Co Reduction of 2-nitroso-5-diethylaminotoluene
US3279880A (en) 1965-07-12 1966-10-18 Eastman Kodak Co Polyester textile material dyed with 1-hydroxy-4-n-p-(2'-pyrrolidonyl-1-) phenyl-amino anthraquinones
LU80081A1 (fr) 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4128654A (en) 1978-02-10 1978-12-05 E. I. Du Pont De Nemours And Company 5-Halomethyl-3-phenyl-2-oxazolidinones
US4500519A (en) 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
HU190072B (en) 1983-03-11 1986-08-28 Biogal Gyogyszergyar,Hu Process for production of medical preparatives with sinergetic influence
NZ206600A (en) 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
ES8506659A1 (es) 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
EP0316594B1 (en) 1987-10-21 1993-09-29 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
DE3822650A1 (de) 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5254577A (en) 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
DE69216251T2 (de) 1991-11-01 1997-05-15 Upjohn Co Substituierte aryl- und heteroaryl-phenyloxazolidinone
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
US5349045A (en) 1993-01-26 1994-09-20 United States Surgical Corporation Polymer derived from cyclic amide and medical devices manufactured therefrom
ES2134870T3 (es) 1993-05-01 1999-10-16 Merck Patent Gmbh Antagonistas del receptor de adhesion.
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE4332384A1 (de) 1993-09-23 1995-03-30 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten III
JPH10513446A (ja) 1995-02-03 1998-12-22 ファルマシア・アンド・アップジョン・カンパニー ヘテロ芳香族環置換フェニルオキサゾリジノン抗微生物剤
HRP960159A2 (en) 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DE19524765A1 (de) 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
KR100463772B1 (ko) 1995-09-01 2005-11-09 파마시아 앤드 업존 캄파니 엘엘씨 4내지8원헤테로사이클릭환에탄소-탄소결합을갖는페닐옥사졸리디논
AU6964096A (en) 1995-09-15 1997-04-01 Pharmacia & Upjohn Company Aminoaryl oxazolidinone n-oxides
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
GB9614238D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
CA2261040C (en) 1996-07-15 2009-01-20 Sankyo Company, Limited Pharmaceutical composition comprising combination useful for treatment or prevention of arteriosclerosis or xanthoma
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
AU737995B2 (en) 1997-05-30 2001-09-06 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
EP0994874A1 (en) 1997-07-11 2000-04-26 PHARMACIA & UPJOHN COMPANY Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents
DE19730847A1 (de) 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9715894D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic derivatives
DE19747261A1 (de) 1997-10-25 1999-04-29 Bayer Ag Osmotisches Arzneimittelfreisetzungssystem
NZ504503A (en) 1997-11-12 2002-10-25 Upjohn Co Oxazolidinone derivatives and pharmaceutical use as antimicrobial agents
US6083967A (en) 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
DE19755268A1 (de) 1997-12-12 1999-06-17 Merck Patent Gmbh Benzamidinderivate
DE19802239A1 (de) 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
CN1288462A (zh) 1998-01-23 2001-03-21 法玛西雅厄普约翰美国公司 噁唑烷酮组合库、组合物和制备方法
WO1999037304A1 (en) 1998-01-27 1999-07-29 Aventis Pharmaceuticals Products Inc. SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS
DE19805117A1 (de) 1998-02-09 1999-08-12 Bayer Ag Neue Oxazolidinone mit azolhaltigen Tricyclen
US20010029351A1 (en) 1998-04-16 2001-10-11 Robert Falotico Drug combinations and delivery devices for the prevention and treatment of vascular disease
PL344049A1 (en) 1998-05-18 2001-09-24 Upjohn Co Enhancement of oxazolidinone antibacterial agents activity by using arginine derivatives
DE19842753A1 (de) 1998-09-18 2000-03-23 Bayer Ag Agitationsunabhängige pharmazeutische Retardzubereitungen und Verfahren zu ihrer Herstellung
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
PE20010851A1 (es) 1999-12-14 2001-08-17 Upjohn Co Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
NZ519725A (en) 1999-12-21 2004-05-28 Upjohn Co Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
AU2225901A (en) 1999-12-28 2001-07-09 Ajinomoto Co., Inc. Aspartame derivative crystals
DE10105989A1 (de) 2001-02-09 2002-08-14 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10110438A1 (de) 2001-03-05 2002-09-19 Bayer Ag Substituierte 2-Oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10110747A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung
DE10110754A1 (de) 2001-03-07 2002-09-19 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10115945A1 (de) 2001-03-30 2002-10-02 Bayer Ag Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10115922A1 (de) 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10134481A1 (de) 2001-07-16 2003-01-30 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
DE10152460A1 (de) 2001-10-24 2003-05-08 Bayer Ag Stents
DE10238113A1 (de) 2001-12-11 2003-06-18 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
US20030161882A1 (en) 2002-02-01 2003-08-28 Waterman Kenneth C. Osmotic delivery system
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004002044A1 (de) 2004-01-15 2005-08-04 Bayer Healthcare Ag Herstellverfahren
DE102004062475A1 (de) 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
CA2597263C (en) 2005-02-14 2017-01-17 Epitopix, Llc Polypeptides from staphylococcus aureus and methods of use
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
PL1934208T3 (pl) 2005-10-04 2011-09-30 Bayer Ip Gmbh Nowa polimorficzna postać 5-chloro-N-({ (5S)-2-okso-3-[4-( 3-okso-4-morfolinylo)-fenylo]-1,3-oksazolidyn-5-ylo}-metylo)-2-tiofenokarboksamidu
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
DE102005047558A1 (de) 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005048824A1 (de) 2005-10-10 2007-04-12 Bayer Healthcare Ag Behandlung und Prophylaxe von Mikroangiopathien
KR101378695B1 (ko) * 2007-04-18 2014-03-31 삼성전자주식회사 통신 시스템에서의 훈련 시퀀스 코드 생성 방법 및 장치

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129378B2 (en) 1999-12-24 2012-03-06 Bayer Pharma Aktiengesellschaft Substituted oxazolidinones and their use in the field of blood coagulation
US7576111B2 (en) 1999-12-24 2009-08-18 Bayer Schering Pharma Ag Substituted oxazolidinones and their use in the field of blood coagulation
US7585860B2 (en) 1999-12-24 2009-09-08 Bayer Schering Pharma Aktiengesellschaft Substituted oxazolidinones and their use in the field of blood coagulation
US7592339B2 (en) 1999-12-24 2009-09-22 Bayer Schering Pharma Aktiengesellschaft Substituted oxazolidinones and their use in the field of blood coagulation
US8822458B2 (en) 1999-12-24 2014-09-02 Bayer Intellectual Property Gmbh Substituted oxazolidinones and their use in the field of blood coagulation
US8530505B2 (en) 1999-12-24 2013-09-10 Bayer Intellectual Property Gmbh Substituted oxazolidinones and their use in the field of blood coagulation
US7767702B2 (en) * 2001-06-20 2010-08-03 Bayer Schering Pharma Aktiengesellschaft Substituted oxazolidinones for combinational therapy
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
US8106192B2 (en) 2003-01-07 2012-01-31 Bayer Pharma Aktiengesellschaft Method for producing 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide
US9402851B2 (en) 2003-11-27 2016-08-02 Bayer Intellectual Property Gmbh Process for the preparation of a solid, orally administrable pharmaceutical composition
US9415053B2 (en) 2003-11-27 2016-08-16 Bayer Intellectual Property Gmbh Solid, orally administrable pharmaceutical composition
US9539218B2 (en) 2005-01-31 2017-01-10 Bayer Intellectual Property Gmbh Prevention and treatment of thromboembolic disorders
US7932278B2 (en) 2005-09-23 2011-04-26 Bayer Schering Pharma Aktiengesellschaft 2-aminoethoxyacetic acid derivatives and their use
US8188270B2 (en) 2005-10-04 2012-05-29 Bayer Schering Pharma Aktiengesellschaft Polymorphous form of 5-chloro-N-({(5S)-2-oxo-3[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide
US8586082B2 (en) 2005-10-04 2013-11-19 Bayer Intellectual Property Gmbh Solid orally administerable pharmaceutical dosage forms with rapid active principle release
WO2012041263A2 (en) 2010-09-30 2012-04-05 Farmak, A.S. A method of manufacturing 2-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]- l,3-oxazolidin-5-yl}methyl)-lh-isoindol-l,3(2h)-dione with a high optical purity

Also Published As

Publication number Publication date
CN1434822A (zh) 2003-08-06
US20130005701A1 (en) 2013-01-03
UA73339C2 (en) 2005-07-15
DOP2000000114A (es) 2002-07-15
NO2009001I2 (US07585860-20090908-C00102.png) 2010-05-11
US20080200674A1 (en) 2008-08-21
BR0017050B1 (pt) 2012-06-12
BE2008C046I2 (US07585860-20090908-C00102.png) 2019-12-16
CU23423B7 (es) 2009-09-08
KR100804932B1 (ko) 2008-02-20
AU775126B2 (en) 2004-07-15
AU2841401A (en) 2001-07-09
EP1526132B1 (de) 2014-03-12
CA2396561A1 (en) 2001-07-05
AU775126C (en) 2005-09-01
RU2297415C2 (ru) 2007-04-20
EP1526132A3 (de) 2005-08-31
PE20010963A1 (es) 2001-11-10
TW200422299A (en) 2004-11-01
FR08C0051I2 (fr) 2009-12-18
CY1115117T1 (el) 2016-12-14
HK1057556A1 (en) 2004-04-08
JP2005068164A (ja) 2005-03-17
GT200000216A (es) 2002-06-12
DE50009607D1 (de) 2005-03-31
JP5190173B2 (ja) 2013-04-24
US20030153610A1 (en) 2003-08-14
WO2001047919A1 (de) 2001-07-05
CO5251440A1 (es) 2003-02-28
PL201121B1 (pl) 2009-03-31
CZ301432B6 (cs) 2010-03-03
ZA200204188B (en) 2003-05-27
US20150166568A1 (en) 2015-06-18
ES2457021T3 (es) 2014-04-24
LU91497I2 (fr) 2009-01-19
CN1772751A (zh) 2006-05-17
NZ537058A (en) 2006-04-28
RU2002120456A (ru) 2004-01-10
SK9082002A3 (en) 2003-04-01
DOP2008000001A (es) 2010-01-15
HUP0203902A3 (en) 2003-07-28
SV2002000245A (es) 2002-01-15
TR200401314T2 (tr) 2004-08-23
NO2009001I1 (no) 2009-02-02
IL205242A (en) 2011-12-29
CN1900074A (zh) 2007-01-24
DK1526132T3 (da) 2014-06-16
DK1261606T3 (da) 2005-05-09
US7592339B2 (en) 2009-09-22
TR200201636T2 (tr) 2002-10-21
BG65683B1 (bg) 2009-06-30
KR20070044075A (ko) 2007-04-26
CY2008019I2 (el) 2009-11-04
NO20023043D0 (no) 2002-06-21
SK287272B6 (sk) 2010-05-07
JP4143297B2 (ja) 2008-09-03
UY34152A (es) 2013-02-28
CN100549008C (zh) 2009-10-14
IL149896A0 (en) 2002-11-10
US7157456B2 (en) 2007-01-02
CZ20022202A3 (cs) 2002-11-13
HN2000000267A (es) 2001-06-13
TWI277615B (de) 2007-04-01
ES2237497T3 (es) 2005-08-01
MY140488A (en) 2009-12-31
EP1261606B1 (de) 2005-02-23
FR08C0051I1 (US07585860-20090908-C00102.png) 2008-10-17
CN1262551C (zh) 2006-07-05
WO2001047919A9 (de) 2002-12-19
MXPA02006241A (es) 2003-01-28
EE200200341A (et) 2003-10-15
AU2004218729A1 (en) 2004-11-04
HK1103235A1 (en) 2007-12-14
SG130939A1 (en) 2007-04-26
CA2396561C (en) 2008-10-14
ATE289605T1 (de) 2005-03-15
PL355665A1 (en) 2004-05-04
US20100137274A1 (en) 2010-06-03
LU91497I9 (US07585860-20090908-C00102.png) 2019-01-02
NO20023043L (no) 2002-08-14
CN1900074B (zh) 2012-07-11
NZ519730A (en) 2005-02-25
LTPA2008018I1 (lt) 2021-04-12
AR032436A1 (es) 2003-11-12
KR20020067569A (ko) 2002-08-22
NO2021009I1 (no) 2021-02-25
US7585860B2 (en) 2009-09-08
US20060258724A1 (en) 2006-11-16
MA25646A1 (fr) 2002-12-31
SI1261606T1 (US07585860-20090908-C00102.png) 2005-08-31
BG106825A (en) 2003-02-28
HK1092140A1 (en) 2007-02-02
EE05169B1 (et) 2009-06-15
US8822458B2 (en) 2014-09-02
KR20070094672A (ko) 2007-09-20
CU23208A3 (es) 2007-06-20
HU226522B1 (en) 2009-03-30
BR0017050A (pt) 2002-11-05
NO323699B1 (no) 2007-06-25
LTC1261606I2 (lt) 2021-05-10
PL200413B1 (pl) 2009-01-30
IL205242A0 (en) 2011-07-31
US7576111B2 (en) 2009-08-18
NL300370I2 (nl) 2009-05-06
NL300370I1 (nl) 2009-02-02
PT1526132E (pt) 2014-04-15
SI1526132T1 (sl) 2014-07-31
JP2003519141A (ja) 2003-06-17
CY2008019I1 (el) 2009-11-04
PT1261606E (pt) 2005-07-29
EP1261606A1 (de) 2002-12-04
US8530505B2 (en) 2013-09-10
TWI226330B (en) 2005-01-11
HUP0203902A2 (hu) 2003-03-28
HRP20060251B1 (hr) 2016-08-12
EP1526132A2 (de) 2005-04-27
US20080090815A1 (en) 2008-04-17
US8129378B2 (en) 2012-03-06
HRP20020617B1 (en) 2006-09-30
NO20070981L (no) 2002-08-14
HRP20060251A2 (en) 2006-12-31
HRP20020617A2 (en) 2004-12-31
US20130316999A1 (en) 2013-11-28
DE122009000014I1 (de) 2009-11-05

Similar Documents

Publication Publication Date Title
DE19962924A1 (de) Substituierte Oxazolidinone und ihre Verwendung
EP1366029B1 (de) Substituierte 2-oxo-3-phenyl-5-carbonylaminomethyl-1,3-oxazoline und ihre verwendung als antikoagulantien und antithrombotika
EP1411932B1 (de) Kombinationstherapie substituierter oxazolidinone
WO2007042146A1 (de) Behandlung und prophylaxe von mikroangiopathien
WO2007039134A1 (de) Kombinationstherapie mit substituierten oxazolidinonen zur prophylaxe und behandlung von cerebralen durchblutungsstörungen
WO2008052671A2 (de) Kombinationstherapie substituierter oxazolidinone
DE10322469A1 (de) Heterocyclische Verbindungen
DE10134482A1 (de) Substituierte Isoindole und ihre Verwendung
DE102005042583A1 (de) Iminooxazolidin-Derivate und ihre Verwendung
EP1414817B1 (de) Substituierte isoindole und ihre verwendung
DE102005052174A1 (de) Phenylen-bis-oxazolidin-Derivate und ihre Verwendung

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee