CA2086968C - Quinazoline derivatives - Google Patents

Quinazoline derivatives

Info

Publication number
CA2086968C
CA2086968C CA002086968A CA2086968A CA2086968C CA 2086968 C CA2086968 C CA 2086968C CA 002086968 A CA002086968 A CA 002086968A CA 2086968 A CA2086968 A CA 2086968A CA 2086968 C CA2086968 C CA 2086968C
Authority
CA
Canada
Prior art keywords
alkyl
alkoxy
amino
quinazoline
alkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002086968A
Other languages
English (en)
French (fr)
Other versions
CA2086968A1 (en
Inventor
Andrew John Barker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929201095A external-priority patent/GB9201095D0/en
Priority claimed from GB929213572A external-priority patent/GB9213572D0/en
Priority claimed from GB929223735A external-priority patent/GB9223735D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of CA2086968A1 publication Critical patent/CA2086968A1/en
Application granted granted Critical
Publication of CA2086968C publication Critical patent/CA2086968C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Cosmetics (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
CA002086968A 1992-01-20 1993-01-08 Quinazoline derivatives Expired - Lifetime CA2086968C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9201095.8 1992-01-20
GB929201095A GB9201095D0 (en) 1992-01-20 1992-01-20 Quinazoline derivatives
GB929213572A GB9213572D0 (en) 1992-06-26 1992-06-26 Quinazoline derivatives
GB9213572.2 1992-06-26
GB9223735.3 1992-11-12
GB929223735A GB9223735D0 (en) 1992-11-12 1992-11-12 Quinazoline derivatives

Publications (2)

Publication Number Publication Date
CA2086968A1 CA2086968A1 (en) 1993-07-21
CA2086968C true CA2086968C (en) 1998-06-23

Family

ID=27266013

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002086968A Expired - Lifetime CA2086968C (en) 1992-01-20 1993-01-08 Quinazoline derivatives

Country Status (22)

Country Link
US (2) US5457105A (Direct)
EP (1) EP0566226B1 (Direct)
KR (1) KR100229294B1 (Direct)
AT (1) ATE130000T1 (Direct)
AU (1) AU661533B2 (Direct)
CA (1) CA2086968C (Direct)
CZ (1) CZ282038B6 (Direct)
DE (1) DE69300754T2 (Direct)
DK (1) DK0566226T3 (Direct)
ES (1) ES2078798T3 (Direct)
FI (1) FI111631B (Direct)
GB (1) GB9300059D0 (Direct)
GR (1) GR3018143T3 (Direct)
HK (1) HK36497A (Direct)
HU (2) HU221622B1 (Direct)
IL (1) IL104479A (Direct)
NO (1) NO301541B1 (Direct)
NZ (1) NZ245662A (Direct)
RU (1) RU2127263C1 (Direct)
SK (1) SK281551B6 (Direct)
TW (1) TW283146B (Direct)
UA (1) UA34426C2 (Direct)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41065E1 (en) 1995-06-06 2009-12-29 Pfizer, Inc. Alkynl and azido-substituted 4-anilinoquinazolines
CN103382182A (zh) * 2013-05-17 2013-11-06 河北医科大学 苯基脲偶联喹唑啉类化合物及其制备方法、药物组合物及药物用途

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* Cited by examiner, † Cited by third party
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