DE602005026328D1 - Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus - Google Patents

Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus

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Publication number
DE602005026328D1
DE602005026328D1 DE602005026328T DE602005026328T DE602005026328D1 DE 602005026328 D1 DE602005026328 D1 DE 602005026328D1 DE 602005026328 T DE602005026328 T DE 602005026328T DE 602005026328 T DE602005026328 T DE 602005026328T DE 602005026328 D1 DE602005026328 D1 DE 602005026328D1
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DE
Germany
Prior art keywords
prevention
treatment
rsv
syncytial virus
respiratory syncytial
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Application number
DE602005026328T
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English (en)
Inventor
Michael A Zeligs
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BioResponse LLC
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BioResponse LLC
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Publication date
Application filed by BioResponse LLC filed Critical BioResponse LLC
Publication of DE602005026328D1 publication Critical patent/DE602005026328D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602005026328T 2004-12-30 2005-12-30 Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus Active DE602005026328D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64030104P 2004-12-30 2004-12-30
PCT/US2005/047537 WO2006083458A2 (en) 2004-12-30 2005-12-30 Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions

Publications (1)

Publication Number Publication Date
DE602005026328D1 true DE602005026328D1 (de) 2011-03-24

Family

ID=36777712

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005026328T Active DE602005026328D1 (de) 2004-12-30 2005-12-30 Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus

Country Status (6)

Country Link
US (2) US7989486B2 (de)
EP (1) EP1838303B1 (de)
AT (1) ATE497762T1 (de)
CA (1) CA2593084C (de)
DE (1) DE602005026328D1 (de)
WO (1) WO2006083458A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US8013006B2 (en) 2004-07-14 2011-09-06 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7989486B2 (en) * 2004-12-30 2011-08-02 Bioresponse, L.L.C. Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
EP1917019A2 (de) * 2005-05-03 2008-05-07 Biopolymer Engineering, Inc. Kombination eines beta-glucans und eines egf-rezeptor-antagonisten zur krebs- und infektionsbehandlung
WO2007016935A1 (en) * 2005-07-29 2007-02-15 Histogenex Nv Methods, reagents and instrumentation for preparing impregnated tissue samples suitable for histopathological and molecular studies
US8586621B2 (en) * 2006-10-27 2013-11-19 Michael A. Zeligs Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
WO2009103755A1 (en) * 2008-02-19 2009-08-27 Dsm Ip Assets B.V. Novel use of 3,3'-diindolylmethane
EP2346507A1 (de) 2008-09-03 2011-07-27 Boehringer Ingelheim International GmbH Verwendung von chinazolin-derivaten zur behandlung von viruserkrankungen
WO2010033198A2 (en) * 2008-09-17 2010-03-25 Sri International Analogs of indole-3-carbinol and their use as agents against infection
CA2744947A1 (en) * 2008-12-19 2010-10-28 The Regents Of The University Of California Use of epidermal growth factor inhibitors in the treatment of viral infection
CN101428016B (zh) * 2008-12-23 2011-06-15 南京大学 二吲哚甲烷及其衍生物在制备治疗类风湿关节炎的药物中的应用
WO2010118339A2 (en) * 2009-04-09 2010-10-14 University Of Kansas Formulations of indole-3-carbinol derived antitumor agents with increased oral bioavailability
GB201004761D0 (en) * 2010-03-22 2010-05-05 Medical Res Council Method
CN102133210A (zh) * 2010-04-28 2011-07-27 重庆医科大学附属儿童医院 白藜芦醇在制备预防和治疗呼吸道合胞病毒感染的药物中的应用
SG187887A1 (en) * 2010-08-18 2013-03-28 Clearfarma Ind Ltd Functional food compositions and methods
GB201105050D0 (en) 2011-03-25 2011-05-11 Iiaa Ltd Pharmaceutical agent
WO2012135133A1 (en) * 2011-04-01 2012-10-04 Sri International Lipoxygenase inhibitors
US20150297593A1 (en) * 2012-09-14 2015-10-22 Children's Medical Center Corporation Inhibition of viral infection-triggered asthma with c-kit inhibitor
CN105272900B (zh) * 2015-01-21 2018-06-19 南通大学 双吲哚类衍生物及其制备方法与应用
AU2016245984B2 (en) 2015-04-10 2021-03-25 Bioresponse, L.L.C. Self-emulsifying formulations of DIM-related indoles
CN105030766A (zh) * 2015-06-24 2015-11-11 安徽四正医药科技有限公司 吲哚-3-甲醇、二吲哚甲烷及其衍生物用于治疗过敏性咽炎药物的应用
WO2017001979A1 (en) * 2015-06-27 2017-01-05 Reform Bio Inc. Diindolyl methane compositions, formulations and use thereof
CN110074978A (zh) * 2019-03-13 2019-08-02 安庆瑄宇医药科技有限公司 一种缬更昔洛韦组合片剂及其制备方法
RU2740377C1 (ru) * 2020-03-18 2021-01-13 Всеволод Иванович Киселёв Способ лечения эндометриоза и сопутствующего спаечного процесса лекарственным средством на основе 3,3'-дииндолилметана в комплексе с B-циклодекстрином
US11529331B2 (en) 2020-05-29 2022-12-20 Boulder Bioscience Llc Methods for improved endovascular thrombectomy using 3,3′-diindolylmethane
CN116585321B (zh) * 2023-02-21 2024-04-26 华中科技大学同济医学院附属协和医院 更昔洛韦在制备治疗过敏性鼻炎药物中的应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5718921A (en) * 1987-03-13 1998-02-17 Massachusetts Institute Of Technology Microspheres comprising polymer and drug dispersed there within
FR2676927B1 (fr) * 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
US5830887A (en) * 1992-05-19 1998-11-03 Novogen Research Pty. Ltd. Health supplements containing phyto-oestrogens, analogues or metabolites thereof
WO1996030347A1 (en) 1995-03-30 1996-10-03 Pfizer Inc. Quinazoline derivatives
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
DK0836605T3 (da) 1995-07-06 2002-05-13 Novartis Ag Pyrrolopyrimidiner og fremgangsmåder til deres fremstilling
US5767135A (en) 1995-12-29 1998-06-16 Fernandez-Pol; Jose Alberto Antiviral agent
US6127393A (en) 1995-12-29 2000-10-03 Novactyl, Inc. Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
EP0892789B2 (de) 1996-04-12 2009-11-18 Warner-Lambert Company LLC Umkehrbare inhibitoren von tyrosin kinasen
US5948808A (en) * 1997-03-07 1999-09-07 The Texas A&M University System Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
JP4427106B2 (ja) * 1997-03-18 2010-03-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 平滑筋腫を治療および診断するための方法およびキット
US6083932A (en) 1997-04-18 2000-07-04 Cv Technologies Inc. Pharmaceutical compositions derived from ginseng and methods of treatment using same
US6150395A (en) * 1997-05-30 2000-11-21 The Regents Of The University Of California Indole-3-carbinol (I3C) derivatives and methods
US6001868A (en) 1997-05-30 1999-12-14 The Regents Of The University Of California Indole-3-carbinol (I3C) derivatives and methods
US5895787A (en) * 1997-10-08 1999-04-20 Designed Nutritional Products, Inc. Treatment of fibromyalgia and related disorders
US6086915A (en) * 1998-04-01 2000-07-11 Bioresponse L.L.C. Compositions and methods of adjusting steroid hormone metabolism through phytochemicals
OA11769A (en) 1998-04-29 2005-07-25 Pfizer Prod Inc N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate.
ATE277010T1 (de) 1998-07-08 2004-10-15 Harbor Branch Oceanographic Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
HUP0104211A3 (en) 1998-11-19 2003-01-28 Warner Lambert Co N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases and pharmaceutical composition containing it
US6613792B1 (en) * 1999-08-02 2003-09-02 Designed Nutritional Products, Inc. Treatment of premenstrual syndrome and menopause
US7384971B2 (en) * 1999-09-23 2008-06-10 Bioresponse L.L.C. Phytochemicals for the treatment of cervical dysplasia
US6534085B1 (en) * 1999-09-23 2003-03-18 Bioresponse L.L.C. Phytochemicals for promoting weight loss
US6689387B1 (en) 1999-09-23 2004-02-10 Bioresponse Llc Phytochemicals for treatment of mastalgia and endometriosis
JP2003510362A (ja) 1999-10-04 2003-03-18 ローレンス・アール・バーンスタイン 細胞内原核生物、dnaウイルス及びレトロウイルスによる感染を治療するための、3−ヒドロキシ−4−ピロンのガリウム錯体
EP1263803B1 (de) * 2000-03-13 2007-09-19 BioCure, Inc. Embolische zusammensetzungen
US6399645B1 (en) * 2000-03-20 2002-06-04 Maria Bell Chemoprevention and treatment of cervical or vaginal neoplasia
AU2001245988A1 (en) * 2000-03-24 2001-10-08 Biosphere Medical, Inc. Microspheres for active embolization
US6477229B1 (en) * 2000-05-12 2002-11-05 Siemens Medical Solutions Usa, Inc. Radiation therapy planning
US6416793B1 (en) 2000-07-11 2002-07-09 Bioresponse, L.L.C. Formulations and use of controlled-release indole alkaloids
US7709520B2 (en) * 2000-10-06 2010-05-04 The Texas A&M University System Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers
US6468557B1 (en) 2001-01-05 2002-10-22 Alphamed Pharmaceutical Corp. Method for treating infectious viral diseases
US20020147155A1 (en) * 2001-04-06 2002-10-10 Foster Warren G. Prevention and treatment of endometriosis with aryl hydrocarbon receptor binding ligands
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
EP1269994A3 (de) 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmazeutische Zusammensetzungen die ein Arzneimittel und die Konzentration verbesserende Polymere enthalten
US7348352B2 (en) * 2001-10-23 2008-03-25 Bioresponse L.L.C. Diindolylmethane for the treatment of HPV infection
US6544564B1 (en) * 2001-11-27 2003-04-08 Michael Donald Farley Cytotoxic pharmaceutical composition
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
US20030220377A1 (en) * 2002-05-08 2003-11-27 Richard Chesworth Indole compounds and their use as estrogen agonists/antagonists
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US8193185B2 (en) * 2003-01-21 2012-06-05 Novartis Vaccines And Diagnostics, Inc. Use of tryptanthrin compounds for immune potentiation
CA2515424A1 (en) 2003-02-06 2004-08-26 Bioresponse, Llc The combined use of cruciferous indoles and chelators for the treatment of papillomavirus-related conditions
US20040235931A1 (en) * 2003-04-17 2004-11-25 John Docherty Inhibition of herpes virus replication
US20050123560A1 (en) * 2003-12-04 2005-06-09 Sinnott Robert A. High purity and water dispersible extract and formulations of larrea tridentata leaf resin, and methods of making and using the same
US8080577B2 (en) 2004-05-06 2011-12-20 Bioresponse, L.L.C. Diindolylmethane formulations for the treatment of leiomyomas
WO2006047716A2 (en) * 2004-10-26 2006-05-04 Bioresponse Llc Use of diindolylmethane-related indoles and growth factor receptor inhibitors for the treatment of human cytomegalovirus associated disease
US20060100264A1 (en) * 2004-11-06 2006-05-11 Bjeldanes Leonard F 3,3'-Diindolylmethane immune activating compositions
US7989486B2 (en) * 2004-12-30 2011-08-02 Bioresponse, L.L.C. Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
US20060229355A1 (en) 2005-04-08 2006-10-12 The Regents Of The University Of California 3.3'-Diindolylmethane compositions inhibit angiogenesis

Also Published As

Publication number Publication date
WO2006083458A3 (en) 2007-10-04
ATE497762T1 (de) 2011-02-15
CA2593084C (en) 2014-03-18
EP1838303B1 (de) 2011-02-09
US7989486B2 (en) 2011-08-02
CA2593084A1 (en) 2006-08-10
EP1838303A4 (de) 2008-06-18
US8552052B2 (en) 2013-10-08
WO2006083458A2 (en) 2006-08-10
US20080103114A1 (en) 2008-05-01
EP1838303A2 (de) 2007-10-03
US20110250267A1 (en) 2011-10-13

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