ATE430154T1 - Amino-substituierte cyclohexan derivate zur behandlung bakterieller infektionen - Google Patents

Amino-substituierte cyclohexan derivate zur behandlung bakterieller infektionen

Info

Publication number
ATE430154T1
ATE430154T1 AT03747857T AT03747857T ATE430154T1 AT E430154 T1 ATE430154 T1 AT E430154T1 AT 03747857 T AT03747857 T AT 03747857T AT 03747857 T AT03747857 T AT 03747857T AT E430154 T1 ATE430154 T1 AT E430154T1
Authority
AT
Austria
Prior art keywords
amino
treatment
bacterial infections
substituted cyclohexane
cyclohexane derivatives
Prior art date
Application number
AT03747857T
Other languages
English (en)
Inventor
Jeffrey Axten
Robert Daines
David Davies
Timothy Gallagher
Graham Jones
William Miller
Neil Pearson
Israil Pendrak
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE430154T1 publication Critical patent/ATE430154T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
AT03747857T 2002-06-26 2003-06-25 Amino-substituierte cyclohexan derivate zur behandlung bakterieller infektionen ATE430154T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39170002P 2002-06-26 2002-06-26
US46096103P 2003-04-07 2003-04-07
PCT/EP2003/006756 WO2004002992A1 (en) 2002-06-26 2003-06-25 Compounds

Publications (1)

Publication Number Publication Date
ATE430154T1 true ATE430154T1 (de) 2009-05-15

Family

ID=30003201

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03747857T ATE430154T1 (de) 2002-06-26 2003-06-25 Amino-substituierte cyclohexan derivate zur behandlung bakterieller infektionen

Country Status (10)

Country Link
US (2) US7622481B2 (de)
EP (1) EP1537123B1 (de)
JP (1) JP4522262B2 (de)
AR (1) AR040335A1 (de)
AT (1) ATE430154T1 (de)
AU (1) AU2003266949A1 (de)
DE (1) DE60327438D1 (de)
ES (1) ES2325831T3 (de)
TW (1) TW200406413A (de)
WO (1) WO2004002992A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
EP2181996A1 (de) 2002-01-29 2010-05-05 Glaxo Group Limited Aminopiperidinderivate
WO2003064431A2 (en) 2002-01-29 2003-08-07 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
DE60334016D1 (de) 2002-11-05 2010-10-14 Glaxo Group Ltd Antibakterielle mittel
JP4704755B2 (ja) 2002-11-05 2011-06-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 抗菌剤
EP1567520B1 (de) 2002-12-04 2008-10-15 Glaxo Group Limited Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
EP1796466A4 (de) 2004-06-15 2009-09-02 Glaxo Group Ltd Antibakterielle mittel
DE102004041163A1 (de) * 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
JP4887297B2 (ja) * 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
CN101039935B (zh) * 2004-10-05 2011-04-20 埃科特莱茵药品有限公司 哌啶抗生素
JP5314244B2 (ja) * 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
US7605169B2 (en) 2005-01-25 2009-10-20 Glaxo Group Limited Antibacterial agents
WO2006081178A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
JP2008528604A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2008528587A (ja) * 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
EP1846418A4 (de) 2005-01-25 2009-12-23 Glaxo Group Ltd Antibakterielle wirkstoffe
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
WO2006137485A1 (ja) * 2005-06-24 2006-12-28 Toyama Chemical Co., Ltd. 新規な含窒素複素環化合物およびその塩
WO2007016610A2 (en) * 2005-08-02 2007-02-08 Glaxo Group Limited Antibacterial agents
CA2635126A1 (en) 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Tetrahydropyrane antibiotics
JP5191053B2 (ja) 2006-02-15 2013-04-24 アクテリオン ファーマシューティカルズ リミテッド エタノールまたは1,2−エタンジオールシクロヘキシル抗生物質誘導体
WO2007118130A2 (en) * 2006-04-06 2007-10-18 Glaxo Group Limited Antibacterial agents
WO2007115947A1 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
JP5171618B2 (ja) * 2006-05-26 2013-03-27 富山化学工業株式会社 新規な複素環化合物またはその塩ならびにその中間体
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (de) 2007-05-18 2008-11-19 Glaxo Group Limited Derivate und Analoge von N-Ethylquinolonen und N-Ethylazaquinolonen
WO2008071962A1 (en) * 2006-12-15 2008-06-19 Astrazeneca Ab Pteridines and pyrimidinopyridines as antibacterial agents
CL2007003693A1 (es) 2006-12-22 2008-06-27 Actelion Pharmaceuticals Ltd Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
AU2008240764C1 (en) 2007-04-20 2011-10-20 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
KR20100088693A (ko) 2007-11-26 2010-08-10 토야마 케미칼 컴퍼니 리미티드 신규한 나프티리딘 유도체 1 수화물 및 그 제조법
EP2080761A1 (de) 2008-01-18 2009-07-22 Glaxo Group Limited Verbindungen
EP2297107B1 (de) * 2008-06-03 2013-11-13 Actelion Pharmaceuticals Ltd. [4-(1-amino-ethyl)-cyclohexyl]-methylamin und [6-(1-amino-ethyl)-tetrahydro-pyran-3-yl]-methylaminderivate als antibakterielle mittel
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
WO2010045987A1 (en) * 2008-10-23 2010-04-29 Glaxo Group Limited Substituted (aza) -1-methyl-1h-quin0lin-2-0nes as antibacterials
MX2011005120A (es) 2008-11-17 2011-05-30 Hoffmann La Roche Acidos naftilaceticos.
EP2379554B1 (de) 2009-01-15 2015-11-11 Glaxo Group Limited Als antibakterielle mittel geeignete naphthyridin-2-(1h)-onverbindungen
CN102361863B (zh) 2009-01-21 2014-12-03 巴斯利尔药物股份公司 新的二环抗生素
AR076222A1 (es) * 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
US8394858B2 (en) 2009-12-03 2013-03-12 Novartis Ag Cyclohexane derivatives and uses thereof
JP5697685B2 (ja) 2009-12-18 2015-04-08 バジリア ファルマスーチカ アーゲーBasilea Pharmaceutica AG 三環式抗生物質
JPWO2012108376A1 (ja) 2011-02-07 2014-07-03 第一三共株式会社 アミノ基含有ピロリジノン誘導体
ES2596369T3 (es) 2011-06-17 2017-01-09 Basilea Pharmaceutica Ag Antibióticos N-heterotricíclicos
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
US9359275B2 (en) * 2012-02-23 2016-06-07 Children's Medical Center Corporation Natural product antibiotics and analogs thereof
CN104936961B (zh) * 2013-03-29 2016-10-26 第一三共株式会社 (1s,4s,5s)-4-溴-6-氧杂二环[3.2.1]辛-7-酮的制备方法
CN103145709A (zh) * 2013-04-12 2013-06-12 苏州科捷生物医药有限公司 一种4-氯-1,6-萘啶的合成工艺
PL2986607T3 (pl) 2013-04-16 2017-11-30 Idorsia Pharmaceuticals Ltd Przeciwbakteryjne pochodne biaromatyczne
WO2015193506A1 (en) * 2014-06-20 2015-12-23 Institut Pasteur Korea Anti-infective compounds
EA031589B1 (ru) 2014-08-22 2019-01-31 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Трициклические азотсодержащие соединения для лечения инфекции, вызываемой neisseria gonorrhoeae
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
PL3209655T3 (pl) 2014-10-24 2020-12-28 Landos Biopharma, Inc. Leczenie oparte na białku 2 podobnym do syntetazy lantioniny C
UY36851A (es) * 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas
WO2019032956A1 (en) 2017-08-10 2019-02-14 President And Fellows Of Harvard College LINCONSAMIDE ANTIBIOTICS AND USES THEREOF
US11124534B2 (en) 2017-08-10 2021-09-21 President And Fellows Of Harvard College Lincosamide antibiotics and uses thereof
EA202091325A1 (ru) 2017-11-30 2020-08-28 Лэндос Байофарма, Инк. Способы лечения с помощью лигандов лантионин c-подобного белка 2 и подготовленных с их помощью клеток
CN108003100A (zh) * 2017-12-20 2018-05-08 北京六合宁远科技有限公司 一种药物中间体含氮杂环的胺类化合物的合成方法
JP7430852B2 (ja) 2019-12-20 2024-02-14 エヌイミューン バイオファーマ インコーポレイテッド ランチオニンc様タンパク質2リガンド、それを用いて調製される細胞、およびそれを使用する療法
CN116102537A (zh) * 2021-11-10 2023-05-12 四川大学 一种喹啉酮类衍生物及其制备方法和用途

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2201674T3 (es) 1998-01-26 2004-03-16 Smithkline Beecham Plc Derivados de quinolina con propiedades antibacterianas.
GB9822450D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
AU2437900A (en) 1999-01-20 2000-08-07 Smithkline Beecham Plc Piperidinylquinolines as protein tyrosine kinase inhibitors
GB9914486D0 (en) * 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
FR2798656B1 (fr) 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
US6403610B1 (en) 1999-09-17 2002-06-11 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them
MXPA02004985A (es) * 1999-11-26 2003-10-14 Shionogi & Co Antagonistas del neuropeptido y, y5.
DE60125373T2 (de) * 2000-07-26 2007-10-18 Smithkline Beecham P.L.C., Brentford Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung
JP2004509885A (ja) 2000-09-21 2004-04-02 スミスクライン ビーチャム パブリック リミテッド カンパニー 抗菌薬としてのキノリン誘導体
FR2816618B1 (fr) 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
US6603005B2 (en) 2000-11-15 2003-08-05 Aventis Pharma S.A. Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them
GB0031088D0 (en) 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031086D0 (en) 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
WO2002078748A2 (en) 2001-01-24 2002-10-10 Becton Dickinson And Company Lubricious coating for medical device
US6602884B2 (en) 2001-03-13 2003-08-05 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them
FR2822154B1 (fr) 2001-03-13 2005-10-21 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0118238D0 (en) 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
EP2181996A1 (de) 2002-01-29 2010-05-05 Glaxo Group Limited Aminopiperidinderivate
WO2003064431A2 (en) 2002-01-29 2003-08-07 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
FR2842807A1 (fr) 2002-07-23 2004-01-30 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant
GB0217294D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicaments
FR2844270B1 (fr) 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
CA2500320A1 (en) 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Novel compounds with antibacterial activity
JP4704755B2 (ja) 2002-11-05 2011-06-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 抗菌剤
DE60334016D1 (de) 2002-11-05 2010-10-14 Glaxo Group Ltd Antibakterielle mittel
EP1567520B1 (de) 2002-12-04 2008-10-15 Glaxo Group Limited Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel
AR042486A1 (es) 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
FR2849034A1 (fr) 2002-12-20 2004-06-25 Aventis Pharma Sa Forme cristalline de l'acide (3r,4r)-4-(3-(s)-hydroxy-3- (6-methoxyquinolin-4-yl) propyl)-1-(2-(2-thienylthio) ethyl piperidine-3- carboxylique
US6939970B2 (en) 2002-12-20 2005-09-06 Aventis Pharma S. A. Crystalline form of (3R,4R)-4-[3-(S)-hydroxy-3-(6 methoxyquinolin-4-propyl]-1-[2-2-thienylthio)ethyl] piperidine-3-carboxylic acid
TW200507841A (en) 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
FR2852954B1 (fr) 2003-03-28 2006-07-14 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
US7232833B2 (en) 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität

Also Published As

Publication number Publication date
JP4522262B2 (ja) 2010-08-11
JP2005539087A (ja) 2005-12-22
US20100081650A1 (en) 2010-04-01
ES2325831T3 (es) 2009-09-21
US20060189604A1 (en) 2006-08-24
AU2003266949A1 (en) 2004-01-19
EP1537123A1 (de) 2005-06-08
DE60327438D1 (de) 2009-06-10
EP1537123B1 (de) 2009-04-29
TW200406413A (en) 2004-05-01
AR040335A1 (es) 2005-03-30
US7622481B2 (en) 2009-11-24
WO2004002992A1 (en) 2004-01-08

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