ES2493916T3 - Inhibidores de hidrolasa de amida de ácidos grasos - Google Patents

Inhibidores de hidrolasa de amida de ácidos grasos Download PDF

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Publication number
ES2493916T3
ES2493916T3 ES10762388.6T ES10762388T ES2493916T3 ES 2493916 T3 ES2493916 T3 ES 2493916T3 ES 10762388 T ES10762388 T ES 10762388T ES 2493916 T3 ES2493916 T3 ES 2493916T3
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alkyl
independently selected
alkynyl
alkenyl
6alkyl
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ES10762388.6T
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Alfredo C. Castro
Michael J. Grogan
Daniel A. Snyder
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Infinity Pharmaceuticals Inc
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Infinity Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Compuesto de fórmula I: o una sal farmacéuticamente aceptable, o solvato del mismo, o mezcla del mismo, en la que: ----- se selecciona entre un enlace sencillo y un doble enlace; cuando ----- es un enlace sencillo, X1 se selecciona entre CR4R5 y NR6, y X2 se selecciona entre CR7R8 y NR9; cuando ----- es un doble enlace, X1 se selecciona entre CR4 y N, y X2 se selecciona entre CR7 y N; X3 se selecciona entre CR10R11 y NR12; con la condición de que al menos uno de X1, X2 y X3 se selecciona entre N, NR6, NR9, y N12; m es 0 o 1; Z1 se selecciona entre -OR13 y alquilo C1-6; Z2 se selecciona entre -OR14 y alquilo C1-6; o alternativamente, Z1 y Z2, junto con el B al que están unidos, forman un anillo de 5 a 8 miembros que tiene al menos un átomo de O unido directamente al B, en el que el anillo está compuesto por átomos de carbono y opcionalmente uno o más heteroátomos adicionales seleccionados independientemente entre el grupo que consiste en N, S, y O; n es 0, 1, 2 o 3; R1 y R2 se seleccionan cada uno independientemente entre H, halógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2- 6, perhaloalquilo C1-6, -CN y -OR15; o alternativamente, R1 y R2, tomados junto con el carbono al que están unidos, forman un grupo carbonilo; R3, en cada aparición, se selecciona independientemente entre halógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2- 6, perhaloalquilo C1-6, -OH, alcoxi C1-6 y -CN; R4, R5, R7, R8, R10, y R11 se seleccionan cada uno independientemente entre H, halógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, perhaloalquilo C1-6, -CN, -OR16, NR17R18, -C(O)R19, carbociclilo C3-10, arilo C6-10, aralquilo C7-12, heterociclilo de 3-10 miembros, y heteroarilo de 5-10 miembros; R6, R9, y R12 se seleccionan cada uno independientemente entre H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, - C(O)R20, S(O)2R22, carbociclilo C3-10, arilo C6-10, heterociclilo de 3-10 miembros, heteroarilo de 5-10 miembros, y - (CR27R28)p-R23; R13 y R14, en cada aparición, se seleccionan cada uno independientemente entre H, alquilo C1-6, alquenilo C2-6, y alquinilo C2-6; R15 y R16, en cada aparición, se seleccionan cada uno independientemente entre H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, carbociclilo C3-10, arilo C6-10, aralquilo C7-12, heterociclilo de 3-10 miembros, y heteroarilo de 5-10 miembros; R17 y R18, en cada aparición, se seleccionan cada uno independientemente entre H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -C(O)R24, -C(O)OR25, carbociclilo C3-10, arilo C6-10, aralquilo C7-12, heterociclilo de 3-10 miembros, y heteroarilo de 5-10 miembros;

Description

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Claims (1)

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ES10762388.6T 2009-04-07 2010-04-07 Inhibidores de hidrolasa de amida de ácidos grasos Active ES2493916T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16745609P 2009-04-07 2009-04-07
US167456P 2009-04-07
PCT/US2010/030272 WO2010118155A1 (en) 2009-04-07 2010-04-07 Inhibitors of fatty acid amide hydrolase

Publications (1)

Publication Number Publication Date
ES2493916T3 true ES2493916T3 (es) 2014-09-12

Family

ID=42936564

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10762388.6T Active ES2493916T3 (es) 2009-04-07 2010-04-07 Inhibidores de hidrolasa de amida de ácidos grasos

Country Status (7)

Country Link
US (2) US8546564B2 (es)
EP (1) EP2416660B1 (es)
JP (1) JP2012523424A (es)
AU (1) AU2010234445A1 (es)
CA (1) CA2757679A1 (es)
ES (1) ES2493916T3 (es)
WO (1) WO2010118155A1 (es)

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TWI770552B (zh) 2014-12-24 2022-07-11 美商基利科學股份有限公司 喹唑啉化合物
EP3237414B1 (en) 2014-12-24 2019-05-08 Gilead Sciences, Inc. Fused pyrimidine compounds for the tratment of hiv
CN119528827A (zh) * 2023-08-31 2025-02-28 北京五和博澳药业股份有限公司 一种酞嗪酮类化合物及其制备方法、药物组合物及用途

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US8546564B2 (en) 2013-10-01
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