WO2011147849A1 - Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent - Google Patents

Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent Download PDF

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Publication number
WO2011147849A1
WO2011147849A1 PCT/EP2011/058506 EP2011058506W WO2011147849A1 WO 2011147849 A1 WO2011147849 A1 WO 2011147849A1 EP 2011058506 W EP2011058506 W EP 2011058506W WO 2011147849 A1 WO2011147849 A1 WO 2011147849A1
Authority
WO
WIPO (PCT)
Prior art keywords
stent
heart valve
prosthetic heart
endoprosthesis
arches
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2011/058506
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English (en)
French (fr)
Inventor
Michael J. Girard
Randy Lane
Arnulf Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jenavalve Technology Inc
Original Assignee
Jenavalve Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenavalve Technology Inc filed Critical Jenavalve Technology Inc
Priority to AU2011257298A priority Critical patent/AU2011257298B2/en
Priority to JP2013511662A priority patent/JP2013526388A/ja
Priority to CN201180036365.4A priority patent/CN103002833B/zh
Priority to BR112012029896A priority patent/BR112012029896A2/pt
Priority to EP11721068.2A priority patent/EP2575681B1/en
Priority to CA2799459A priority patent/CA2799459A1/en
Publication of WO2011147849A1 publication Critical patent/WO2011147849A1/en
Priority to IL222936A priority patent/IL222936A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes

Definitions

  • the present disclosure relates to a prosthetic heart valve. Specifically, the present disclosure relates to a prosthetic heart valve for a transcatheter delivered
  • endoprosthesis used in the treatment of a stenotic cardiac valve and/or a cardiac valve insufficiency.
  • the present disclosure also relates to a transcatheter delivered endoprosthesis that includes a prosthetic heart valve and a stent for positioning and anchoring of the prosthetic heart valve at the implantation site in the heart of a patient.
  • the present disclosure also relates to a collapsible and expandable prosthesis incorporating a prosthetic heart valve and a stent that can be delivered to the implant site using a catheter for treatment of a stenosis (narrowing) of a cardiac valve and/or a cardiac valve insufficiency.
  • narrowing (stenosis) of a cardiac valve and/or cardiac valve insufficiency may include a functional defect of one or more cardiac valves, which is either genetic or has developed.
  • a cardiac defect of this type might affect each of the four heart valves, although the aortic and mitral valves are affected much more often than the right-sided part of the heart (pulmonary and tricuspid valves).
  • the functional defect can result in narrowing (stenosis), inability to close (insufficiency) or a combination of the two (combined vitium).
  • This disclosure relates to a prosthetic heart valve as well as a transcatheter delivered endoprosthesis that includes a prosthetic heart valve and an expandable stent capable of being implanted transluminal ⁇ in a patient's body and enlarged radially after being introduced by transcatheter delivery for treating such a heart valve defect.
  • the human heart has four valves which control the blood flow circulating through the human body.
  • the mitral valve located between the left atrium and the left ventricle
  • the aortic valve located between the left ventricle and the aorta. Both of these valves direct the oxygenated blood, coming from the lungs into the aorta for distribution through the body.
  • the tricuspid valve, located between the right atrium and the right ventricle, and the pulmonary valve, located between the right ventricle and the pulmonary artery are situated on the right side of the heart and direct deoxygenated blood, coming from the body, to the lungs.
  • the native heart valves are passive structures that open and close in response to differential pressures induced by the pumping motions of the heart. They consist of moveable leaflets designed to open and close in response to the said differential pressure.
  • the mitral valve has two leaflets and the tricuspid valve has at least two, preferably three leaflets.
  • the aortic and pulmonary valves have normally at least two, preferably three leaflets, also often referred to as "cusps" because of their half-moon like appearance.
  • the terms "leaflet” and "cusps" have the same meaning.
  • Heart valve diseases are classified into two major categories, named stenosis and insufficiency.
  • stenosis the native heart valve does not open properly, whereby insufficiency represents the opposite effect showing deficient closing properties.
  • Medical conditions like high blood pressure, inflammatory and infectious processes can lead to such cardiac valve dysfunctions. Either way in most cases the native valves have to be treated by surgery.
  • treatment can either include reparation of the diseased heart valve with preservation of the patient's own valve or the valve could be replaced by a mechanical or biological substitutes also referred to as prosthetic heart valves.
  • aortic heart valves it is frequently necessary to introduce a heart valve replacement.
  • the first way includes extracting at least major parts of the diseased heart valve.
  • the second alternative way provides leaving the diseased heart valve in place and pressing the diseased leaflets aside to create space for the prosthetic heart valve.
  • Biological or mechanical prosthetic heart valves are typically surgically sewn into the cardiac valve bed through an opening in the chest after removal of the diseased cardiac valve. This operation necessitates the use of a heart-lung machine to maintain the patient's circulation during the procedure and cardiac arrest is induced during implantation of the prosthesis. This is a risky surgical procedure with associated dangers for the patient, as well as a long post-operative treatment and recovery phase. Such an operation can often not be considered with justifiable risk in the case of polypathic patients.
  • Minimally-invasive forms of treatment have been developed recently which are characterized by allowing the procedure to be performed under local anesthesia.
  • One approach provides for the use of a catheter system to implant a self- expandable stent to which is connected a collapsible heart valve.
  • a self- expandable endoprosthesis can be guided via a catheter system to the implantation site within the heart through an inguinal artery or vein. After reaching the implantation site, the stent with the prosthetic heart valve affixed thereto can then be unfolded.
  • certain embodiments of the present disclosure address the issue of providing a prosthetic heart valve, as well as a self-expandable endoprosthesis for treating a narrowed cardiac valve or a cardiac valve insufficiency which realizes optimum long term durability, excellent hemodynamics (e.g.
  • the disclosure provides an improved attachment of a prosthetic heart valve to a corresponding collapsible stent structure, thereby distributing stress loads over a greater surface area and thus reducing the potential for stress concentration points throughout the prosthetic heart valve, resulting in improved durability.
  • the disclosure provides a prosthetic heart valve for a transcatheter delivered endoprosthesis used in the treatment of a stenosis (narrowing) of a cardiac valve and/or a cardiac valve insufficiency.
  • the prosthetic heart valve comprises at least two leaflets, a skirt portion, and a transition area representing a junction between the leaflets and the skirt portion.
  • Each of the at least two leaflets of the prosthetic heart valve consists of natural tissue or synthetic material and has a first opened position for opening the patient's heart chamber and a second closed position for closing the patient's heart chamber, the at least two leaflets being able to switch between their first and second position in response to the blood flow through the patient's heart.
  • the skirt portion consists of natural tissue or synthetic material and is used for mounting of the prosthetic heart valve to a stent.
  • the transition area which represents a junction between the at least two leaflets of the prosthetic heart valve and the skirt portion, progresses approximately in a U-shaped manner, similar to a cusp shape of a natural aortic or pulmonary heart valve, thereby reducing stresses within the heart valve material during opening and closing motion of the at least two leaflets.
  • natural tissue as used herein means naturally occurring tissue, i.e. biological tissue obtained from the patient, from another human donor, or from a nonhuman animal.
  • naturally occurring tissue i.e. biological tissue obtained from the patient, from another human donor, or from a nonhuman animal.
  • the herein used expression “natural tissue” shall also cover tissue fabricated by tissue engineering in the laboratory, for example, from combinations of engineered extracellular matrices ("scaffolds”), cells, and biologically active molecules.
  • the prosthetic heart valve either comprises xenografts / homografts or synthetic, nonbiological, non-thrombogenic materials.
  • Homografts are either human donor valves, e.g., heart valves, or replacements made of human tissue, e.g., pericardial tissue.
  • xenografts describe valves received from animals, e.g., heart valves, or made of animal tissue, e.g., pericardial tissue, typically porcine or bovine respectively. These natural tissues normally contain tissue proteins (i.e., collagen and elastin) acting as a supportive framework and
  • the natural tissue may be exposed to one or more chemical fixatives (i.e. tanning agents) that form cross-linkages between the polypeptide chains within the protein structures of the natural tissue material.
  • chemical fixative agents include: formalaldehyde, glutaraldehyde, dialdehyde starch, hexamethylene diisocyanate and certain polyepoxy compounds.
  • some embodiments of the disclosure describe an improved construction of the prosthetic heart valve, the design of the disclosed prosthetic heart valve is suited for reducing stresses, and reducing the potential for calcification to improve durability of the heart valve.
  • the disclosure provides an improved attachment of a prosthetic heart valve to a corresponding collapsible stent structure, thereby distributing stress loads over a greater surface area and thus reducing the potential for stress concentration points throughout the prosthetic heart valve, resulting in improved durability.
  • the prosthetic heart valve may be made of one piece of flat pericardial tissue.
  • This pericardial tissue can either be extracted from an animal's heart (xenograft) or a human's heart (homograft). Subsequently, the extracted tissue may be cut by a laser cutting system, a die press, a water jet cutting system or by hand with a variety of cutting instruments in order to form a pattern representing each of the at least two leaflets or in another embodiment individual leaflets. This pattern may also include the skirt portion in some
  • the skirt portion represents an area of the prosthetic heart valve that is used for connecting the prosthetic heart valve to a stent, for example, by means of sutures.
  • Current prosthetic heart valves consist of separated leaflets and skirt portions, wherein the separated leaflets and skirt portions are sewn together by the time the biological heart valve is connected to the stent.
  • the leaflets are integrally formed with the leaflet support portion, that is the prosthetic heart valve is made of one piece of flat pericardial tissue.
  • the pattern of the prosthetic heart valve which represents each of the at least two and preferably three leaflets and the skirt portion, shall substantially be constructed like a native aortic or pulmonary heart valve.
  • the pattern is preferably designed so as to form leaflets in the aforementioned cusp manner, having three half-moon shaped leaflets like the aortic or pulmonary heart valve.
  • the leaflets can be designed in various shapes such as the geometry of an ellipse, U-shape or substantially oval .
  • each of the three different leaflets is formed in such a manner that all of them have the same extent; however, it is also conceivable to design them in different sizes.
  • the shaping of the leaflets into said pattern for minimizing stresses in the closed position of the prosthetic heart valve, can be achieved in several ways.
  • the mechanical properties of the leaflets of the prosthetic heart valve are influenced by the free margin and the shape of the supported edges.
  • the leaflets are formed into a predetermined 3D shape, by means of a cross-linking the flat tissue on a mandrel . Subsequently, potentially occurring excess material is trimmed off by means of a laser, knife, or water jet respectively to form the edges of the 3D shape.
  • the valve pattern shows a transition area progressing in a substantial U-shaped manner, similar to the cusp shape of a natural aortic or pulmonary heart valve.
  • the lower end section of the prosthetic heart valve exhibits a tapered or flared shape. Such a tapered or flared shape may be advantageous regarding the attachment of the prosthetic heart valve to a corresponding stent. As will be explained in more detail hereinafter, a
  • the corresponding stent may comprise a tapered or flared lower end section in order to improve the anchoring of the stent at the implantation site.
  • the leaflets may have a cuspidal geometry, which is formed in an elliptically, u-shaped or oval manner. Such a cuspdial geometry reduces the potential for stress concentrations and therefore minimizes the potential for areas of wear and calcium deposition.
  • all three leaflets are shaped to the same extent, absorbing loads equally throughout the cardiac cycle. However, it is conceivable to assemble a device with leaflets of varying designs.
  • the leaflet portion of the prosthetic heart valve is designed to provide redundant coaptation for potential annular distortion.
  • redundant coaptation means that each of the leaflets covers more than one third of the inner diameter of the respective stent, in the closed position of the valve.
  • the redundant coaptation may reduce stress on the leaflets and provides reliable closure of the heart chamber in the second closed position of the leaflets, even in the case of an annular distortion. That is, the prosthetic heart valve of the present disclosure is capable of preventing
  • the prosthetic heart valve comprises a plurality of fastening holes provided along the progression of the bendable transition area. These fastening holes are preferably introduced into the tissue of the prosthetic heart valve before the valve is attached to the
  • This plurality of fastening holes may reduce the time needed for attachment of the prosthetic heart valve to the retaining arches of the
  • the prosthetic heart valve is designed for collapsing and delivering in a catheter.
  • the prosthetic heart valve can be designed in such a way as to fit inside the corresponding stent structure.
  • the design of the prosthetic heart valve comprises certain folds in order to allow for collapsing to very small
  • the tissue material of the prosthetic heart valve has a thickness of 160 ⁇ to 300 ⁇ , preferably from 220 ⁇ to 260 ⁇ .
  • the thickness may be dependent on the tissue material of the prosthetic heart valve.
  • the thickness of bovine tissue is thicker than the thickness of porcine tissue.
  • the prosthetic heart valve may have a diameter ranging form 19 mm to 28 mm.
  • the prosthetic heart valve of the present disclosure is adapted to fit to the individual characteristics of individual patient's heart anatomy.
  • the bendable transition area of the prosthetic heart valve is attached to retaining arches of the stent by means of sutures, having a diameter larger than the diameter of the sutures used for attachment of the prosthetic heart valve to an annular collar of the stent. Due to this, the prosthetic heart valve can be reliably attached to the stent without adding too much bulk to the stent, in order to collapse the endoprosthesis to a small diameter.
  • the disclosure also provides a transcatheter delivered endoprosthesis having a prosthetic heart valve affixed to a stent.
  • the stent provides retaining arches which are configured once in the expanded state to be in a gradually uniform U-shape.
  • the transition area of the tissue is attached to the retaining arches of the stent in a number of possible embodiments.
  • the purpose of the retaining arches is to control the motion of the leaflets during the opening and closing phases of the valve in a manner which minimizes the stresses associated with the cyclic motion.
  • the leaflets are integrally formed with the skirt portion.
  • a single piece of pericardium may be used for forming the prosthetic heart valve.
  • the skirt portion may consist of multiple pieces of tissue, e.g . three pieces of tissue, which are sewn together by the time the biological heart valve is connected to the stent, wherein the leaflets are integrally formed with the tissue material of the pieces which together form the skirt portion.
  • three individual tissue panels may be utilized to construct the valve portion of the prosthetic heart valve.
  • the tissue structure is sutured to the stent structure to create the desired U-shape of the leaflets.
  • This U-shape helps distribute the load on the leaflets throughout the cardiac cycle, but especially when in the closed position.
  • the advantages of not having a seam include reduced assembly time (less suturing), less overall bulk when collapsing the prosthesis for small catheter delivery and more flexible leaflets at the transition area that could improve leaflet motion and hemodynamics.
  • the natural tissue material used for the manufacture of prosthetic heart valves typically contains connective tissue proteins (i.e., collagen and elastin) that act as supportive framework of the tissue material .
  • connective tissue proteins i.e., collagen and elastin
  • a chemical fixation process may be performed, linking the proteins together.
  • This technique usually involves the exposure of the natural tissue material to one or more chemical fixatives that form the cross-linkages between the polypeptide chains of the collagen molecules.
  • the leaflets of the prosthetic heart valve could be treated by a different chemical fixative agent than the skirt portion in order to obtain diverse rigidity within the prosthetic heart valve.
  • leaflets and a skirt which are not integral .
  • different cross-linking techniques may be applied to the leaflets and the skirt.
  • aldehydes e.g. formaldehyde, glutaraldehyde, dialdehyde starch, para formaldehyde
  • aldehydes e.g. formaldehyde, glutaraldehyde, dialdehyde starch, para formaldehyde
  • glyceroaldehyde glyoxal acetaldehyde, acrolein
  • diisocyanates e.g .,
  • the prosthetic heart valve is mounted to the inner surface of a support stent.
  • This arrangement facilitates protection of the prosthetic heart valve material during collapse and deployment. This is because the prosthetic heart valve is not in contact with the inner wall of the implantation catheter, and thus may not get stuck on the inner surface thereof. On this account, damage to the prosthetic heart valve is avoided. Also, such an endoprosthesis can be collapsed to a smaller diameter compared with a prosthetic heart valve mounted to the outer surface of the stent, hence providing the possibility to use smaller catheters.
  • the skirt portion could be in direct contact with the diseased native heart valve and could be attached to the stent by means of sutures. Mounting the prosthetic heart valve to the outer surface of the stent supports the load transfer from the leaflet to the stent. This greatly reduces stresses on the leaflets during closing and consequently improves the durability thereof. Also, it is possible to design the valve to obtain improved hemodynamics in the case of mounting the skirt portion and commissures to the outer surface of the stent.
  • the heart valve material which is in direct contact with the diseased native heart valve provides a good interface for sealing against leakage (i.e., paravalvular leakage), tissue in-growth and attachment.
  • leakage i.e., paravalvular leakage
  • tissue in-growth tissue in-growth and attachment.
  • the stent designs for this endoprosthesis uniquely accommodate this valve embodiment and advantages, whereas for cage-like transcatheter delivered stent designs this is not possible.
  • the prosthetic heart valve can be made from pericardial tissue, for example, human pericardial tissue, preferably animal pericardial tissue, whereby bovine or porcine pericardial tissue is preferred.
  • pericardial tissue for example, human pericardial tissue, preferably animal pericardial tissue, whereby bovine or porcine pericardial tissue is preferred.
  • bovine or porcine pericardial tissue is preferred.
  • porcine tissue thicknesses of 220 to 260 ⁇ after fixation shall be used to manufacture the biological prosthetic heart valves.
  • this example is not a limitation of the possible kinds of tissues and their dimensions. Rather, it is conceivable to employ kangaroo, ostrich, whale or any other suitable xeno- or homograft tissue of any feasible dimension.
  • Many aspects of the disclosed prosthetic heart valve embodiments may become clear considering the structure of a corresponding stent to which the prosthetic heart valve may be attached in order to form a transcatheter delivered
  • endoprosthesis used in the treatment of a stenosis (narrowing) of a cardiac valve and/or a cardiac valve insufficiency.
  • a stent suitable for implantation with the aforementioned prosthetic heart valve may comprise positioning arches configured to be positioned within the pockets of the patient's native heart valve. Furthermore, the stent may comprise retaining arches. In detail, for each positioning arch one retaining arch may be provided. In the implanted state of the stent, the respective head portions of the positioning arches are positioned within the pockets of the patient's native heart valve such that the positioning arches are located on a first side of a plurality of native heart valve leaflets. On the other hand, in the implanted state of the stent, the retaining arches of the stent are located on a second side of the native heart valve leaflets opposite the first side.
  • the positioning arches on the one hand and the retaining arches on the other hand clamp the native heart valve leaflets in a paper-clip manner.
  • the positioning arches of the stent are designed to engage in the pockets of the native (diseased) cardiac valve which allows accurate positioning of the stent and a prosthetic heart valve affixed to the stent.
  • each positioning arch co-operates with a corresponding retaining arch resulting in clipping of the native leaflet between the two arches. In this way, the positioning and retaining arches hold the stent in position and substantially eliminate axial rotation of the stent
  • the positioning arch may be formed such as to have a substantially convex shape. In this way, the shape of each positioning arch provides an additional clipping force against the native valve leaflet.
  • the at least one retaining arch of the stent may be connected to a corresponding positioning arch by a connecting web.
  • the retaining arch may extend substantially parallel to the positioning arch, thus having essentially the same shape.
  • the shape of the retaining arch basically represents a U-shape with a small gap at its lower end. This gap is surrounded by a connection portion which originates during the fabrication of the tip of the positioning arches.
  • the connection portion may be similar to a U- or V-shape and links the two sides of a retaining arch.
  • a plurality of fastening holes and optionally one or more notches may be provided.
  • these fastening holes and notches are longitudinally distributed at given positions along the retaining arches and guide at least one thread or thin wire to fasten the tissue components of the prosthetic heart valve to the stent, thereby enabling a precise positioning of the tissue components on the stent.
  • the means provided for fastening the tissue components of the biological prosthetic heart valve to the retaining arches of the stent is guided by way of the fastening holes and notches to ensure accurate repeatable securement of the bioprosthetic heart valve within the stent structure. This accurate securement of the biological prosthesis substantially reduces the potential for longitudinal displacement of the biological prosthetic heart valve relative to the stent.
  • the aforementioned plurality of retaining arches are provided with one or more fastening notches which can be used to fix the bendable transition area to the stent.
  • the retaining arches may be segmented by a plurality of bending edges forming said fastening notches and defining bending points of the retaining arches.
  • the fastening notches simplify the attachment of the bendable transition area of the prosthetic heart valve to the retaining arches.
  • the retaining arches are cut from the material portion of a small metal tube in an shape that when expanded essentially form the U-shaped structure corresponding to the aforementioned progression of the transition area.
  • annular collar may be provided at the lower end of the stent.
  • the annular collar may serve as a supporting body through which the radial forces, developing due to the self-expansion, are transmitted to the vascular wall.
  • Attached to the annular collar is the skirt portion of the biological prosthetic heart valve. Typically, this attachment is implemented by means of suturing.
  • the intent of the self expanding annular collar in combination with the attached skirt region of the valve is to provide sufficient radial forces so as to seal and prevent paravalvular leakage.
  • the collar aids in anchoring the prosthesis in the annulus to prevent migration.
  • This collar may incorporate a flared or tapered structure to further enhance securement.
  • a prosthetic heart valve can be attached to a corresponding stent in order to provide a transcatheter delivered endoprosthesis which can be used in the treatment of a stenosis (narrowing) of a cardiac valve and/or a cardiac valve insufficiency.
  • a prosthetic heart valve made from pericardial tissue material may be attached to the retaining arches and annular collar of the afore-mentioned stent by means of braided multi-filament polyester sutures. These sutures may have any suitable diameter, typically about 0.07 mm.
  • the size of the multifilament sutures for example, up to 0.2 mm. In this way, it is possible that the fundamental bond between the transition area of the prosthetic heart valve and the retaining arches of the stent exhibits additional stability. On the other hand, the remaining sutures shall be kept as thin as possible to enable collapsing of the endoprosthesis to a small diameter.
  • a common running stitch pattern may be used to obtain said bonding.
  • the stitch pattern is preferably a locking stitch or a blanket stitch respectively.
  • any other suitable stitch pattern i.e. overlocking stitch, slipstitch or topstitch is also possible.
  • another aspect of the disclosure may provide that the material of the prosthetic heart valve is reinforced to improve its suture retention force.
  • laser cut suturing holes may be introduced into the prosthetic heart valve tissue with the laser cutting process strengthening the tissue area around the cut hole. Predefined laser cutting holes might also ease the suturing process itself and reduce stresses on the material of the prosthetic heart valve due to the penetration of the needle during stitching .
  • connection of the prosthetic heart valve material to a stent may be reinforced by means of reinforcement elements.
  • reinforcement elements are intended to reduce stress concentrations in the material of the prosthetic heart valve that may occur from direct stitching in the valve material.
  • the reinforcement elements might reduce stress concentration in the tissue material of the prosthetic heart valve at the connection between the bendable transition area and the retaining arches of the stent.
  • the reinforcement elements may be placed between an inner suture and the prosthetic heart valve material, thus distributing aforementioned stresses, caused by the stitching, over a larger area of the valve material.
  • These reinforcement elements can be used at discrete locations or continuously along the path of the stitching. For example, they can be placed opposite to the retaining arches of the stent on the other side of the prosthetic heart valve material.
  • Reinforcement elements may be applied in order to avoid direct contact between knots of the sutures and the tissue of the prosthetic heart valve, thereby reducing abrasion of the prosthetic heart valve tissue due to rubbing against said sutures.
  • reinforcement elements can further be used to prevent the tissue of the prosthetic heart valve from directly contacting the stent structure or any other metallic component respectively.
  • such reinforcement elements could also be located at or near the upper edge of the leaflets. These upper edges, building the commissures of the endoprosthesis, are exposed to an increased tension, which are more likely to tear during the operation of the prosthetic heart valve.
  • This alternative embodiment may be especially useful in order to reinforce the leaflets of the prosthetic heart valve in order to increase their ability to yield mechanical stresses occurring during the operation of the endoprosthesis.
  • Reinforcement elements can be used at discrete locations or continuously along the path of the stitching. For example, they can be placed opposite to the retaining arches of the stent on the other side of the prosthetic heart valve material.
  • the reinforcement elements may be folded or formed in such a way that round edges are formed. These round edges are designed to reduce or avoid abrasion of the valve material during opening and closing of the prosthetic heart valve.
  • the reinforcement elements comprise at least one inner cushion, which is mounted to the inner surface of the bendable transition area of the prosthetic heart valve.
  • This inner cushion is arranged essentially opposite the retaining arches and/or to the commissure attachment region of the stent. Opposite in this context means that the inner cushion is mounted on an opposite side of the prosthetic heart valve.
  • the inner cushion is designed to reduce the stress concentrations in the tissue that occur from direct stitching in the tissue.
  • the inner cushion prevents the prosthetic heart valve tissue from directly contacting knots of the suture. Due to this, wear of the heart valve tissue is reduced, as said knots do not rub on the surface of the tissue, during opening and closing of the heart valve.
  • the at least one inner cushion may be a pledget made of one or multiple layer materials.
  • the inner cushion may consist of materials, for examples, like polyester velour, PTFE, pericardial tissue or any other material suitable for forming round edges, distributing or buffering stresses in the valve material, due to the sutures.
  • the material of the inner cushion can be made from flat sheets or fabrics such as knits or woven constructions.
  • the reinforcement elements can be applied in order to span between stent struts, in particular across a gap, located at the lower end of the retaining arches, to help support the valve material across said gap.
  • the reinforcement elements may consist of a wire rail placed at the inner surface of the bendable transition area of the prosthetic heart valve, essentially opposite the retaining arch of the stent.
  • the wire rail may be secured in place using a stitch pattern meant to accommodate the wire rail and the valve material to the stent. In comparison to the inner cushion mentioned above, such a wire rail could be easier to attach to the material of the prosthetic heart valve.
  • the already rounded shape of the rail does not require the wire rail to be folded in order to obtain rounded edges for prevention of valve material abrasion. It is preferable that said wire rail is made of Nitinol in order to allow collapsing of the reinforcement element simultaneously with the stent structure.
  • the reinforcement elements may be essentially of the same size and form as the retaining arches of the stent, hence forming an inner attachment rail.
  • the reinforcement elements shall be of thinner material than the retaining arches. This is due to the fact that thick material may limit the ability of the endoprosthesis to be collapsed to a small size.
  • the inner attachment rail may have the same fastening holes and notches longitudinally distributed at given locations as the retaining arches of the stent.
  • the attachment rail may be placed on the inner surface of the bendable transition area of the prosthetic heart valve, opposite to the retaining arches of the stent.
  • the material of the prosthetic heart valve may be clamped in between the stent and the reinforcement element, which are connected through sutures.
  • the reinforcement element thus may act as an inner attachment rail for the leaflets of the prosthetic heart valve to bend over and evenly distribute stress loads affecting the valve material over a large attachment rail rather than individual suture points.
  • sutures to fix the reinforcement element or valve material to the stent
  • different attachment methods like welding, soldering, locking fixture and rivets.
  • these methods could be used to attach the aforementioned inner attachment rail to the retaining arches of the stent. This would result in clamping the prosthetic heart valve material in between the inner surface of the stent and the outer surface of the reinforcement element without penetrating the valve material with needles of suture.
  • Another alternative attachment concept includes a reinforcing element attached to the back side of the prosthetic heart valve material. This concept may be suitable for attachment in a high stress area of a commissure attachment region on top of the retaining arches, which is described in more detail below.
  • This concept involves creating a strengthened region by folding the prosthetic heart valve material and wrapping it with the reinforcing element.
  • the reinforcement element forms an outer wrapping element which is mounted to the outer surface of the bendable transition area of the prosthetic heart valve, at the commissure attachment region of the stent.
  • the reinforced bendable transition area of the prosthetic heart valve can then be securely attached to the retaining arches of the stent or the commissure attachment region of the stent.
  • the aforementioned outer wrapping element of the reinforcing element is preferably made of a polymer material such as PTFE or a PET fabric or sheet. However, it could also be a more rigid U-shaped clip or bendable material that can pinch the folded valve material.
  • PTFE polymer material
  • PET fabric or sheet a polymer material
  • this concept has over the other reinforcing elements is that the reinforcing material is not placed on the inner surface of the prosthetic heart valve, hence does not disrupt the blood flow or potentially be a site for thrombus formation.
  • the outer wrapping element of the reinforcing element may also provide an opening buffer to keep the valve leaflet material from opening too wide and hitting the stent, which would cause wear of the valve material. Similar to the rounded edges of the other reinforcement elements, these buffers should be rounded, smooth or soft to avoid wear when the open valve material hits them. The buffer should be small enough to not significantly over restrict leaflet material opening.
  • An especially beneficial embodiment of the present invention includes an attachment concept with reinforcement elements attached to the inner surface and to the outer surface of the transition area of the prosthetic heart valve. This configuration optimally prevents stress concentration and resulting wear of the prosthetic heart valve.
  • a first reinforcement element is connected to the outer surface of the bendable area of the prosthetic heart valve, preferably lining the retaining arches and the commissure attachment region over their entire length.
  • reinforcement element which is connected to the outer surface of the prosthetic heart valve, can be made of animal pericardial tissue, such as the one used for the prosthetic heart valve itself. Of course, it is conceivable to use any other suitable material for the reinforcement element, such as synthetic materials or even homograft (human) tissue.
  • the reinforcement element, connected to the outer surface of the prosthetic heart valve has several advantages, such as preventing any rubbing and wear between the leaflet and the stent at the retaining arches or commissure attachment region respectively. Even if the attachment is tightly sutured, the tissue will have strain cycles at the surface during opening and closing motion of the leaflets, which can cause wear against the stent from micro
  • the reinforcement element allows for an additional spring- like compression to tighten the attachment of the leaflet to the stent, providing a more durable attachment than the one achieved by suturing the leaflets to a rigid surface. Also, the reinforcement element serves as a bumper during opening to limit full opening and reduce the accompanied shock affecting the prosthetic heart valve at opening.
  • the reinforcement element which is connected to the outer surface of the prosthetic heart valve, extends along the retaining arches and along the commissure attachment region, having a wider surface than the surface of the retaining arches or the surface of the commissure attachment region respectively. For this reason, the reinforcement element provides a surface, sufficient to cover the retaining arches and the commissure attachment region completely. Thus, abrasion or wear of the tissue at the retaining arches or commissure attachment region respectively is avoided reliably.
  • reinforcement element is secured firmly to the retaining arches or commissure attachment region respectively, providing a stable surface for attachment of the prosthetic heart valve.
  • the reinforcement element which is connected to the inner surface of the transition area of the prosthetic heart valve
  • the reinforcement element consists of a folded strip of porcine pericardium and is attached to the transition area and stent by means of sutures.
  • This folded strip of porcine pericardium allows the sutures to spread out the compressive forces that secure the leaflet tissue.
  • a tight suture attachment is required to avoid any movement or slipping under physiological loads. If attached tightly, the loads from the leaflet will be at least partially transferred to the stent through friction and not directly to the sutures at the needle holes. This minimizes the stress concentration by spreading out the stresses, especially at the commissure attachment region.
  • the strip of porcine pericardium serves as a bumper to absorb the impact of the tissue during closing and reduces the dynamic stresses transferred to the sutures.
  • the reinforcement element which is connected to the inner surface of the prosthetic heart valve, such as wires, brackets, synthetic materials or even homograft (human) tissue.
  • the aforementioned reinforcement element has to be constructed with a minimal size, so as to avoid the formation of a gap in between the closed leaflets.
  • the reinforcement elements are wrapped in tissue to avoid wear of the prosthetic heart valve tissue during operation. This is especially advantageous in the case of the implementation of rigid reinforcement elements, such as wires or brackets.
  • the tissue, wrapped around the reinforcement elements provides a soft contact surface for the prosthetic heart valve tissue and hence prevents it from rubbing and reduces wear.
  • other stent structures may also be wrapped in tissue or any other suitable synthetic cover. That is, in order to avoid abrasion of the prosthetic heart valve against the stent structure (e.g. retaining arches), the stent may be wrapped in tissue or any other suitable material.
  • the heart valve tissue may not be sutured directly to the metallic stent structure but to the tissue or synthetic material covering it. This could provide a closer contact between the prosthetic heart valve and the stent so as to reliably prevent paravalvular leakage.
  • Yet another modification of the present disclosure includes exposing the prosthetic heart valve material surface and structure to polymeric material in order to reinforce it.
  • Materials according to this embodiment could be cyanoacrylates or polyepoxides which imply excellent bonding of body tissue and could even be used for suture-less surgery.
  • the bendable transition portion of the prosthetic heart valve material includes a layering of various materials with differing mechanical properties used to improve the durability of the prosthetic heart valve.
  • layer materials with very high suture retention strength overlapping the valve material in regions of very high stress load may be applied.
  • material layers with high suture retention in lower parts of the transition area of the prosthetic heart valve may be provided, whereas the upper parts of the transition area shall be designed to be flexible for improving the durability of the valve. Examples for such layer materials will be explained in more detail, with reference to the "reinforcement elements" below.
  • an attachment for the prosthetic heart valve material that reduces the concentration of stresses at the bendable transition portion is disclosed.
  • the bendable transition portion of the prosthetic heart valve is attached to the retaining arches of the stent by folding the valve material from the outside of the stent through slotts provided along the retaining arches.
  • the edges of the slotted retaining arches may be rounded and smooth to avoid abrading or wearing of the valve material.
  • there is some material thickness on the outside of the stent which could impinge on the anchoring of the stent at the position of the diseased natural prosthetic heart valve.
  • the prosthetic heart valve is assembled with three separate pieces of pericardial tissue.
  • the three separate pieces of pericardial tissue are advantageous regarding the thickness of the prosthetic heart valve tissue.
  • the thickness of the leaflets can vary and result in less desirable valve performance, unsymmetrical valve opening and closure or less desirable hemodynamics, such as a short durability or insufficient leaflet closure. Therefore, three smaller pieces of pericardial tissue provide the possibility to form prosthetic heart valve with more uniform thicknesses and mechanical properties.
  • each of the three separate pieces has a flat tissue pattern in an essentially T-shirt like shape, exhibiting sleeves for connection between the adjacent pieces.
  • the adjacent pieces can be constructed, as to reinforce the contiguous edges of the adjacent pieces.
  • the sleeves of adjacent pieces can be folded to the outside and sutured together to reinforce the joining connection. Attaching this reinforced area to the stent commissure attachment region helps to more uniformly distribute leaflet stresses supported by the commissure attachment.
  • the reinforcement elements consist of outer wrapping elements, wrapped around the sleeves of the three separate pieces, in order to reinforce the prosthetic heart valve and attach it to the commissure attachment region of the stent. That is, an outer wrapping element can be used in order to further improve the durability of the prosthetic heart valve.
  • the outer wrapping element can consist of a piece of pericardial tissue or a synthetic material respectively. Also, the outer wrapping element is used to attach the reinforced prosthetic heart valve to the commissure attachment region of the stent by means of sutures.
  • transcatheter delivered endoprosthesis according to the present disclosure in greater detail . Shown are:
  • Fig. 1 a roll-out view of a prosthetic heart valve according to an exemplary embodiment of the disclosure
  • Fig.2a a plan view of the upper end of the prosthetic heart valve in its closed state
  • Fig.2b a plan view of the upper end of the prosthetic heart valve in its opened state
  • Fig. 3 a flat pattern of a prosthetic heart valve material piece having an
  • Fig. 4 a top view of the three prosthetic heart valve material pieces sewn
  • FIG. 5a a flat roll-out view of an exemplary embodiment of a first cardiac valve stent which may be used in the endoprosthesis according to Figs. 6a, 6b, 7a or 7b for fixing a prosthetic heart valve according to an exemplary embodiment of the disclosure;
  • Fig. 5b a first perspective side view of a first cardiac valve stent capable of supporting and anchoring a prosthetic heart valve according to an exemplary embodiment of the disclosure, whereby the cardiac valve stent is shown in its expanded state;
  • Fig. 5c a second perspective side view of a first cardiac valve stent capable of supporting and anchoring a prosthetic heart valve according to an exemplary embodiment of the disclosure, whereby the cardiac valve stent is shown in its expanded state;
  • Fig. 5d a third perspective side view of a first cardiac valve stent capable of supporting and anchoring a prosthetic heart valve according to an exemplary embodiment of the disclosure, whereby the cardiac valve stent is shown in its expanded state;
  • Fig. 5e a plan view of the lower end of a first cardiac valve stent capable of supporting and anchoring a prosthetic heart valve according to an exemplary embodiment of the disclosure, whereby the cardiac valve stent is shown in its expanded state;
  • Fig. 6a a first perspective side view of an endoprosthesis for treating a
  • the endoprosthesis is shown in an expanded state and where the endoprosthesis comprises a cardiac valve stent and a prosthetic heart valve according to an exemplary embodiment of the disclosure, said cardiac valve stent is used for holding the prosthetic heart valve;
  • Fig. 6b a second perspective side view of an endoprosthesis for treating a narrowed cardiac valve or a cardiac valve insufficiency, where the endoprosthesis is shown in an expanded state and where the endoprosthesis comprises a cardiac valve stent and a prosthetic heart valve according to an exemplary embodiment of the disclosure, said cardiac valve stent is used for holding the prosthetic heart valve; a first perspective side view of an endoprosthesis for treating a narrowed cardiac valve or a cardiac valve insufficiency, where the endoprosthesis is shown in an expanded state and where the endoprosthesis comprises a cardiac valve stent and a prosthetic heart valve according to an exemplary embodiment of the disclosure, said cardiac valve stent is used for holding the prosthetic heart valve; a second perspective side view of the endoprosthesis depicted in Fig.
  • FIG. 7a where the endoprosthesis is shown in an expanded state and where the endoprosthesis comprises a cardiac valve stent and a prosthetic heart valve according to an exemplary embodiment of the disclosure, said cardiac valve stent is used for holding the prosthetic heart valve; a flat roll-out view of an exemplary embodiment of a second cardiac valve stent, in its compressed state, which may be used in the endoprosthesis according to Fig. 11a or Fig. l ib for fixing a prosthetic heart valve according to an exemplary embodiment of the disclosure; a first perspective side view of the second cardiac valve stent capable of supporting and anchoring a prosthetic heart valve according to an exemplary embodiment of the disclosure, whereby the cardiac valve stent is shown in its expanded state; Fig.
  • FIG. 8c a second perspective side view of the second cardiac valve stent capable of supporting and anchoring a prosthetic heart valve according to an exemplary embodiment of the disclosure, whereby the cardiac valve stent is shown in its expanded state;
  • Fig. 8d a second flat roll-out view of an exemplary embodiment of a second cardiac valve stent, in its expanded state, which may be used in the endoprosthesis according to Fig. 11a or Fig. l ib for fixing a prosthetic heart valve according to an exemplary embodiment of the disclosure;
  • FIG. 9 a flat roll-out view of an exemplary embodiment of a third cardiac valve stent, in its expanded state, which may be used in an endoprosthesis for fixing a prosthetic heart valve according to an exemplary embodiment of the disclosure; a flat roll-out view of an exemplary embodiment of a fourth cardiac valve stent, in its expanded state, which may be used an endoprosthesis for fixing a prosthetic heart valve according to an exemplary embodiment of the disclosure; a first perspective side view of an endoprosthesis for treating a narrowed cardiac valve or a cardiac valve insufficiency, where the endoprosthesis is shown in an expanded state and where the endoprosthesis comprises a cardiac valve stent and a prosthetic heart valve according to an exemplary embodiment of the disclosure, said cardiac valve stent is used for holding the prosthetic heart valve; a second perspective side view of the endoprosthesis depicted in Fig.
  • FIG. 11a where the endoprosthesis is shown in an expanded state and where the endoprosthesis comprises a cardiac valve stent and a prosthetic heart valve according to an exemplary embodiment of the disclosure, said cardiac valve stent is used for holding the prosthetic heart valve; a perspective top view of the endoprosthesis depicted in Fig. 11a, where the endoprosthesis is shown in an expanded state and where the endoprosthesis comprises a cardiac valve stent and a prosthetic heart valve according to an exemplary embodiment of the disclosure, said cardiac valve stent is used for holding the prosthetic heart valve; a cross sectional view along the line A-A shown in Figs.
  • FIG. 6b or l ib showing a first exemplary embodiment of reinforcement elements which may be utilized in the endoprosthesis according to the present disclosure for fixing a prosthetic heart valve to a cardiac valve stent; a cross sectional view along the line A-A shown in Fig. 6b or l ib showing a second exemplary embodiment of reinforcement elements which may be utilized in the endoprosthesis according to the present disclosure for fixing a prosthetic heart valve to a cardiac valve stent;
  • Fig. 14 a cross sectional view along the line A-A shown in Fig. 6b or l ib
  • showing a third exemplary embodiment of reinforcement elements may be utilized in the endoprosthesis according to the present disclosure for fixing a prosthetic heart valve to a cardiac valve stent;
  • Fig. 15 a cross sectional view along the line B-B shown in Fig . 6b or l i b for explaining a fourth exemplary embodiment of reinforcement elements which may be utilized in the endoprosthesis according to the present disclosure for fixing a prosthetic heart valve to a cardiac valve stent;
  • Fig. 16 a cross sectional view along the line B-B shown in Fig. 6b or l i b
  • Fig. 17 a cross sectional view along the line B-B shown in Fig. 6b or l i b
  • Fig. 18 a cross sectional view along the line B-B shown in Fig . 6b or l i b
  • Fig. 19a-c the steps for connecting two separate prosthetic heart valve material pieces along their contiguous edges according to the second exemplary embodiment of the prosthetic heart valve;
  • Fig. 20 a top view of the attachment of the prosthetic heart valve to the
  • Fig. 21 a detailed perspective view of an alternative attachment of the
  • prosthetic heart valve to the commissure attachment regions of a stent according to the second exemplary embodiment of the prosthetic heart valve.
  • Fig. 1 shows a view of a flat tissue pattern for a prosthetic heart valve 100 according to an exemplary disclosed embodiment.
  • the prosthetic heart valve 100 may comprise at least two leaflets, and as shown in the exemplary embodiment of the flat tissue pattern for a prosthetic heart valve 100 depicted in Fig . 1 three leaflets 102.
  • Each of the leaflets 102 comprises a natural tissue and/or synthetic material .
  • the leaflets 102 are attached to a skirt portion 103. As will be discussed later on in detail, the skirt portion 103 is used for mounting the prosthetic heart valve 100 to a stent 10.
  • the leaflets 102 of the prosthetic heart valve 100 are adapted to be moveable from a first opened position for opening the heart chamber and a second closed position for closing the heart chamber.
  • the leaflets 102 may switch between their first and second position in response to the blood flow through the patient's heart.
  • ventricular systole pressure rises in the left ventricle of the patient's heart.
  • the leaflets 102 of prosthetic heart valve 100 opens, allowing blood to exit the left ventricle into the aorta.
  • pressure in the left ventricle rapidly drops.
  • the aortic pressure forces the leaflets 102 of the prosthetic heart valve 100 to close.
  • Figs. 2a and 2b respectively show a plan view of the upper end of a prosthetic heart valve 100 in the closed and opened state.
  • the three leaflets 102 come together in the centre of the prosthetic heart valve 100 thereby creating a region of sealing.
  • the leaflets pivot about a bendable transition area 104, as depicted in Fig. 1.
  • the bendable transition area 104 forms a junction between the leaflets 102 and the skirt portion 103 and progresses in a substantial U-shaped manner, similar to the cusp shape of a natural aortic or pulmonary heart valve.
  • the commissure region 105 and the leaflets 102 move radially outwards opening the valve in response to increased differential pressure allowing blood to flow through the prosthesis.
  • the prosthetic heart valve 100 is made of one piece of flat pericardial tissue.
  • This pericardial tissue can either be extracted from an animal's heart (xenograft) or a human's heart (homograft).
  • the extracted tissue may be cut by a laser or knife or might be pressed in order to form a flat tissue pattern representing each of the leaflets 102 and the skirt portion 103.
  • the so made heart valve tissue may be sewn into a cylindrical or conical shape, ready to be attached to a corresponding stent structure 10.
  • the skirt portion 103 represents an area of the prosthetic heart valve 100 that is used for connecting the prosthetic heart valve 100 to a stent 10, for example, by means of sutures 101.
  • the pattern of the prosthetic heart valve 100 represents each of the leaflets 102, commissure region 105 and the skirt portion 103 of the intended prosthetic heart valve 100.
  • the flat tissue pattern is designed so as to form the leaflets 102 in a manner, having three half-moon shaped leaflets like the aortic or pulmonary heart valve.
  • the leaflets 102 can be designed in various shapes such as the geometry of an ellipse, U-shape or substantially oval .
  • the three leaflets 102 are formed in such a manner that all of them have the same general shape.
  • Another aspect shown by Fig . 1 is a flared lower end section of prosthetic heart valve 100. As will be explained in more detail below, such a flared lower end section may be advantageous in order to fit the prosthetic heart valve 100 to an annular collar 40 of a respective cardiac heart valve 10. Alternatively, it is further
  • a prosthetic heart valve 100 comprising a tapered lower end section.
  • a flare or taper at the lower end section of the prosthetic heart valve 100 may be adapted to the geometry of the blood vessel at the implantation site of the prosthesis, so as to obtain the most reliable fit of said prosthesis to said blood vessel .
  • the valve pattern shows the bendable transition area 104 progressing in a substantial U-shaped manner, similar to the cusp-shape of a natural aortic or pulmonary heart valve.
  • the leaflet portion of the prosthetic heart valve 100 is designed to provide redundant coaptation for potential annular distortion.
  • the redundant coaptation may reduce stress on the leaflets 102 and assures a reliable closure of the heart chamber in the second closed position of the leaflets 102.
  • This redundant coaptation provides for more surface contact between the leaflets, allowing for the prosthetic heart valve of the present disclosure to be implanted in a distorted valve annulus, still maintaining sufficient coaptation.
  • the prosthetic heart valve 100 can comprise a plurality of fastening holes 106 provided along the progression of the transition area 104. These fastening holes 106 are introduced into the tissue material of the prosthetic heart valve 100 by means of laser cutting for strengthening the tissue area around the fastening holes 106. Alternatively, however, it is conceivable that fastening holes 106 are introduced by the needle during the sewing process.
  • the bendable transition area 104 shown in Fig. 1 may include a layering of various materials with differing mechanical properties. Accordingly, the lower parts, particularly associated with retaining arches of a cardiac valve stent, may be more rigid to provide high suture retention, whereas the upper parts, particularly associated with a commissure attachment region l ib of the stent, may be designed to be more flexible in order to support the movement of the leaflets 102. On the same note, the leaflets 102 and the leaflet support portion 103 may exhibit different stability characteristics. This might be achieved by the use of different cross-linking processes for the leaflets 102 or the leaflet support portion 103 respectively.
  • leaflets 102 or the leaflet support portion 103 could be reinforced by attaching small sheets of tissue or synthetic material in order to increase the mechanical stability.
  • prosthetic heart valves 100 As the size and diameter of different blood vessels of different patients varies to a certain extent, it may be advantageous to provide prosthetic heart valves 100 of different designs.
  • tissue material with a thickness of 160pm to 300 pm, more preferably 220 ⁇ to 260 ⁇ may be used, depending on the particular tissue material used to manufacture the prosthetic heart valve.
  • the prosthetic heart valve 100 may have a diameter ranging form 19 mm to 28 mm.
  • FIGS. 6a, b respectively show a first and second perspective side view of an endoprosthesis 1 for treating a narrowed cardiac valve or a cardiac valve insufficiency, where the endoprosthesis 1 comprises an exemplary embodiment of a cardiac valve stent 10 for holding a prosthetic heart valve 100.
  • the endoprosthesis 1 is shown in an expanded state.
  • the transition area 104 of the prosthetic heart valve 100 extends along the retaining arches 16a, 16b, 16c and, in particular, along the lower leaflet attachment region 11c and the commissure attachment region l ib of the retaining arches 16a, 16b, 16c of the stent 10.
  • the bendable transition area 104 of the prosthetic heart valve 100 is attached to retaining arches 16a, 16b, 16c of the stent 10 such as to enable the leaflets 102 of the prosthetic heart valve 100 to bend inwards in a controlled manner to the centre of the stent 10 forming the valvular leaflets 102.
  • the pattern of the flat-tissue material of the prosthetic heart valve 100 shall be cut so as to incorporate the leaflet structures, the annular skirt portion 103 and the transition area 104 in between them.
  • the valve exhibits a flared portion at the lower end. This flared geometry fits the structure of the stent 10 and is constructed to optimally fit the vascular wall at the implantation site of the diseased heart valve.
  • the prosthetic heart valve 100 which is affixed to the stent 10, consists of a one piece flat pericardial tissue material extracted from an animal or human pericardial sack and cut into a pattern representing each of the three leaflets 102 and the skirt portion 103, wherein the pattern is sewn into a cylindrical shape before attachment to the stent 10.
  • the prosthetic heart valve 100 includes a transition area 104 which is connected to the retaining arches 16a, 16b, 16c and commissure attachment regions l ib of the stent. The transition area 104 connects the leaflets 102 with the skirt portion 103.
  • the transition area 104 is essentially U-shaped, similar to the cusp shape of a natural aortic or pulmonary heart valve. For this reason, the transition area 104 allows for an opening and closing motion of the leaflets 102, causing minimal stresses within the biological prosthetic heart valve tissue.
  • this tissue pattern see Fig. 1
  • the regions of tissue between the retaining arches become the valve leaflets 102.
  • These leaflets can be folded inwards so as to form three essentially closed leaflets.
  • the leaflets 102 are forced apart, in the direction of the stent 10, enabling blood to exit the heart chambers.
  • a suitable stent 10, to which the prosthetic heart valve 100 may be attached for forming an endoprosthesis 1, may include an annular collar 40 arranged to a lower section of stent 10.
  • the annular collar 40 of the stent 10 serves as an additional anchoring measure to hold the transcatheter delivered endoprosthesis 1 in a desired location at the site of the diseased heart valve.
  • the annular collar 40 of the stent 100 has a flared shape.
  • the lower part of leaflet support portion 103 of the prosthetic heart valve 100 affixed to the stent 10 also exhibits an extended diameter in order to accommodate the flared shape of the annular collar 40.
  • the prosthetic heart valve 100 is fixed to the stent 10 by means of sutures, threads or wires 101 which are attached to the skirt portion 103 and/or the transition area 104 of the prosthetic heart valve 100.
  • the skirt portion 103 serves for keeping the prosthetic heart valve 100 in a predefined position relative to the stent 10.
  • a suitable stent 10, to which the prosthetic heart valve 100 may be attached for forming an endoprosthesis 1, may include an annular collar 40 arranged to a lower section of stent 10.
  • the annular collar 40 of the stent 10 serves as an additional anchoring measure to hold the transcatheter delivered endoprosthesis 1 in a desired location at the site of the diseased heart valve.
  • the skirt portion 103 of the prosthetic heart valve 100 may also be attached to the annular collar 40 of the stent 10 by means of sutures, threads or wires 101.
  • sutures, threads or wires 101 may be used.
  • multi-filament sutures 101 of a diameter up to 0.2 mm, preferably between 0.1 mm and 0.2 mm may be used.
  • a common running stitch pattern may be used to obtain said bonding.
  • the stitch pattern is preferably a locking stitch or a blanket stitch respectively.
  • any other suitable stitch pattern i.e.
  • the bendable transition area 104 of the prosthetic heart valve may be attached to retaining arches 16a, 16b, 16c of the stent 10 by means of sutures 101, having a diameter larger than the diameter of the sutures 101 used for attachment of the prosthetic heart valve to an annular collar 40 of the stent 10. Due to this, the prosthetic heart valve 100 can be reliably attached to the stent without adding too much bulk to the stent 10, in order to collapse the endoprosthesis to a small diameter.
  • the annular collar 40 of the stent 100 has a flared shape. Accordingly, the lower part of skirt portion 103 of the prosthetic heart valve 100 affixed to the stent 10 also exhibits an extended diameter in order to accommodate the flared shape of the annular collar 40.
  • the scope of the present disclosure will become more clear by considering some of the possible embodiments of a stent 10 with the prosthetic heart valve 100 attached thereto thereby forming an endoprosthesis. Hence, reference is made in the following to Figs. 5a-e for describing an exemplary embodiment of a stent 10 to which a prosthetic heart valve 100 may be affixed in order to form the transcatheter delivered endoprosthesis 1 depicted in Figs. 6a, b.
  • Fig . 5b is a first perspective side view of a cardiac valve stent 10, whereby the cardiac valve stent 10 is shown in its expanded state.
  • Second and third side views of the cardiac valve stent 10 in its expanded state are shown in Figs. 5c and 5d.
  • Fig. 5e shows a plan view of the lower end of the cardiac valve stent 10 according to the exemplary embodiment of the disclosure in its expanded state, whereas a flat roll-out view of a stent 10 according to the exemplary embodiment is shown in Fig . 5a.
  • the stent 10 depicted in Figs. 5a-e is also provided with an annular collar 40 which is arranged at the lower end section of the stent body.
  • the at least one collar 40 may serve as an additional anchoring measure for the stent 10.
  • the stent 10 has a total of three positioning arches 15a, 15b, 15c, which undertake the function of automatic positioning of the stent 10.
  • Each of the positioning arches 15a, 15b, 15c has a radiused head portion 20, which engages in the pockets of the native heart valve being treated during positioning of the stent 10 at the implantation site in the heart.
  • the exemplary embodiment of the stent 10 also includes radial arches 32a, 32b, 32c.
  • the stent 10 has three radial arches 32a, 32b, 32c, with each arch 32a, 32b, 32c located between the two arms 15a, 15a', 15b, 15b', 15c, 15c' of each positioning arch 15a, 15b, 15c.
  • Each radial arch 32a, 32b, 32c has a shape that is roughly inverse to each positioning arch 15a, 15b, 15c and extends in the opposite direction to each one of the positioning arches 15a, 15b, 15c.
  • the stent 10 according to the exemplary embodiment depicted in Figs. 5a-e is provided with corresponding retaining arches 16a, 16b, 16c.
  • Each one of the retaining arches 16a, 16b, 16c is allocated to one of the positioning arches 15a, 15b, 15c.
  • a number of commissure attachment regions l ib with a number of additional fastening holes 12c is configured at one end of each arm 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c.
  • the stent 10 also comprises second lower leaflet attachment regions 11c for additional fastening of the tissue component(s) of a prosthetic heart valve 100 (see Figs. 6a, b).
  • the stent 10 according to the exemplary embodiment depicted in Figs. 5a-e has a configuration with a number of attachment regions l ib, 11c to attach the material of a prosthetic heart valve 100.
  • the stent 10 may also be provided with leaflet guard arches, wherein one leaflet guard arch may be provided in between each positioning arch 15a, 15b, 15c.
  • leaflet guard arches The structure and function of the leaflet guard arches will be described later with reference to Figs. 7a and 7b.
  • one leaflet guard arch may be allocated to each positioning arch 15a, 15b, 15c.
  • the exemplary embodiment of the sent 10 is characterized by a specific structure of the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c have a shape similar to a prosthetic heart valve 100.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c are provided with a number of lower leaflet attachment regions 11c, each having a number of additional fastening holes 12a or eyelets provided for fastening the tissue component(s) of a prosthetic heart valve 100.
  • These additional fastening holes 12a or eyelets provide attachment points for the bendable transition area 104 of a prosthetic heart valve 100 attached to the stent 10.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c may be provided with a number of fastening notches which can be used to fix the bendable transition area 104 to stent 10.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c have a shape that
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c follow the shape of the bendable transition area 104 of a prosthetic heart valve 100 affixed to the stent 10 in its expanded state.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c are designed to have a minimized unsupported gap from one arm to the other arm of a retaining arch 16a, 16b, 16c at the location behind the positioning arches 15a-c.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c are provided with a plurality of bending edges 33. These bending edges 33 divide each arm 16a', 16a", 16b', 16b", 16c', 16c" into a plurality of arm segments.
  • the arm segments of a single arm 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c are interconnected thereby constituting a retaining arch arm which describes an essentially straight line in the not-expanded state of the stent 10.
  • the stent structure and in particular the structure of the retaining arches 16a, 16b, 16c is programmed such that the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c have a curved shape in the expanded state of the stent 10.
  • the shape of the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c is such defined that the arms follow the shape of the transition area 104 of a prosthetic heart valve 100 to be affixed to the stent 10 (see Figs. 6a and 6b).
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c of the stent 10, onto which the transition area 104 of a prosthetic heart valve 100 is sewn or sewable, will change their shape when the stent 10 expands, wherein the retaining arches 16a, 16b, 16c are curved in the expanded state of the stent 10, but relatively straight when the stent 10 is collapsed.
  • the curvature of the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c is achieved by segmenting the arms 16a', 16a", 16b', 16b", 16c', 16c".
  • the arms 16a', 16a", 16b', 16b", 16c', 16c" are segmented by providing a plurality of bending edges 33.
  • two neighboring arm segments are angled relative to each other, wherein the bending point of these two neighboring arm segments is defined by the bending edge 33 which is provided in between the both neighboring arm segments.
  • the shape of the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c can be precisely adapted to the shape of transition area 104 of a prosthetic heart valve 100 to be affixed to the stent 10. Also, it should be noted that the embodiments depicted in Figs.
  • the stent 10 depicted in Figs. 5a-e is also provided with an annular collar 40 which is arranged at the lower end section of the stent body.
  • the at least one annular collar 40 may serve as an additional anchoring measure for the stent.
  • the stent 10 corresponds to a stent pursuant the exemplary embodiment previously described with reference to Figs. 5a-e.
  • the prosthetic heart valve 100 affixed to the stent 10 corresponds to the exemplary embodiment of the prosthetic heart valve 100 previously described with reference to Fig. 1 and Figs. 2a, b.
  • the prosthetic heart valve 100 affixed to the stent 10 comprises three leaflets 102 made from a biological or synthetic material .
  • the stent 10 comprises a plurality of fastening portions in the form of lower leaflet attachment regions 11c, essentially extending in the longitudinal direction L of stent 10.
  • the stent 100 is provided with commissure attachment regions l ib.
  • the prosthetic heart valve 100 is fastened to the stent 10 by means of sutures 101, threads or a thin wire which is guided through fastening holes 12a, 12c of the lower leaflet attachment regions 11c and the commissure attachment regions l ib respectively. This allows fixing of the tissue components of the prosthetic heart valve 100 to the stent 10 at a predefined position relative to the stent 10.
  • the sutures 101, threads or wires may be guided by fastening notches provided along the retaining arches 16a, 16b, 16c, instead of the aforementioned fastening holes 12a.
  • the fastening holes 12a of the lower leaflet attachment region 11c are replaced by notches (provided by bending edges 33), whereas the commissure attachment region l ib may still be provided with fastening holes 12c.
  • a pericardial prosthetic heart valve 100 is used which is sewn to fastening holes 12a, 12c provided in the fastening portions of the retaining arches 16a, 16b, 16c, i.e. the lower leaflet attachment regions 11c on the one hand and in the commissure attachment regions l ib on the other hand.
  • the skirt portion 103 may be sewn to the annular collar 40 as well as other parts of the stent structure.
  • the prosthetic heart valve 100 may be tubular with a substantially circular cross-section.
  • mount the prosthetic heart valve 100 to the outer surface of a support stent 1. That is, the skirt portion 102 could be in direct contact with the diseased native heart valve and could be attached to the stent 10 by means of sutures. Mounting the prosthetic heart valve 100 to the outer surface of the stent 10 supports the load transfer from the leaflet 102 to the stent 1. This greatly reduces stresses on the leaflets 102 during closing and consequently improves the durability thereof. Also, it is possible to design the valve to obtain improved hemodynamics in the case of mounting the skirt portion and commissures to the outer surface of the stent. Additionally, the heart valve material which is in direct contact with the diseased native heart valve provides a good interface for sealing against leakage (i.e., paravalvular leakage), tissue in-growth and
  • the material for the prosthetic heart valve 100 and, in particular the material for the leaflets 102 of the prosthetic heart valve 100 can be made from synthetics, animal valves or other animal tissues such as pericardium.
  • the animal tissues can be from a number of types of animals.
  • the leaflet material of the prosthetic heart valve 100 is from either bovine or porcine pericardium, but other animals can also be considered, for example equine, kangaroo, etc.
  • the reinforcement elements 107.1 to 107.8 may reduce the stress concentration in the tissue material of the prosthetic heart valve 100 at the connection between the bendable transition area 104 and the lower leaflet attachment region 11c (Figs. 12 to 14) and/or the commissure attachment regions l ib (Figs. 15 to 17) of the stent 10.
  • the reinforcement elements 107.1 to 107.8 can be at discrete locations or continuously along the path of the stitching. For example, they can be placed opposite to the retaining arches of the stent on the other side of the prosthetic heart valve material .
  • the depicted reinforcement elements 107.1 to 107.8 are applied in order to strengthen the attachment to the stent and reduce stress concentrations in the leaflet material that would occur by suturing directly to the bendable transition portion 104 or leaflet support portion 103 respectively. Further to this, the reinforcement elements 107.1 to 107.8 may avoid direct contact between knots of the sutures and the tissue of the prosthetic heart valve. Also, direct contact between the heart valve tissue and the stent structure or any other metallic component of the endoprosthesis can be avoided by the reinforcement elements.
  • the reinforcement elements 107.1 to 107.8 are preferably designed with rounded edges to avoid abrasion of the valve tissue during opening and closing of the prosthetic heart valve 100.
  • Fig . 12 shows a cross sectional view along the line A-A in Fig. 6b or Fig. l ib respectively, i.e. a cross sectional view of one retaining arch 16a, 16b, 16c of the stent 10 utilized in an endoprosthesis 1 of the present disclosure.
  • a first exemplary embodiment of reinforcement elements 107.1 may be utilized for fixing the prosthetic heart valve 100 to the stent 10.
  • connection of the prosthetic heart valve tissue to the stent 10 is reinforced by means of at least one reinforcement element in the form of a inner cushion 107.1 which is intended to reduce stress concentrations in the tissue material of the prosthetic heart valve 100, said that stress concentrations may occur from direct stitching in the tissue material of the prosthetic heart valve 100.
  • the at least one reinforcement element in the form of the inner cushion 107.1 is placed between a suture 101.1 and the tissue material of the prosthetic heart valve 100. In this respect, any stress caused by the suture
  • the at least one reinforcement element in the form of the inner cushion 107.1 is placed opposite to the corresponding retaining arch 16a, 16b, 16c of the stent 10 on the other side of the tissue material of the prosthetic heart valve 100. That is, the at least one reinforcement element in the form of the inner cushion 107.1 is mounted to the inner surface of the bendable transition area 104 of the prosthetic heart valve 100.
  • the at least one inner cushion 107.1 representing a first embodiment of the reinforcement elements may be folded in such a way that at least one round edge 108 is formed. This at least one round edge 108 is designed to avoid abrasion of tissue material of the leaflets 102 during opening and closing of the prosthetic heart valve 100.
  • the reinforcement element in the form of the inner cushion 107.1 may be made of one or multiple layer materials, consisting of materials like polyester velour, PTFE, pericardial tissue, or any other material suitable for forming round edges, distributing or buffering stresses in the tissue material of the prosthetic heart valve 100.
  • the reinforcement element in the form of the inner cushion 107.1 can be applied to span across the gap formed between the lower end of two neighbouring arms 16a', 16a"; 16b', 16b"; 16c', 16c" of one retaining arches 16a, 16b, 16c (see Fig. 6a) for supporting the tissue material of the prosthetic heart valve 100 across the gap.
  • Fig. 6a Reference is further made to Fig.
  • the reinforcement element may be made of one or multiple layer materials and consisting of materials like polyester velour, PTFE, pericardial tissue or any other material suitable for forming round edges.
  • the tissue material of the prosthetic heart valve 100 may be attached to the commissure attachment region l ib in such a manner that when the leaflets 102 are folded together, during closure of the heart valve, a small cavity 109 is created. Inside this cavity 109, a reinforcement element in the form of an inner cushion 107.2 is inserted. It has to be noted that the cavity 109 is formed, so as to be as small as possible in order to avoid leakage during the closing phase of the heart valve prosthesis 1.
  • Fig. 13 is a cross sectional view along the line A-A shown in Fig . 6b or l ib for explaining a third exemplary embodiment of reinforcement elements which may be utilized in the endoprosthesis 1 according the present disclosure.
  • the reinforcement element may consist of a wire rail 107.3 which is substantially at the same place as the reinforcement elements consisting of an inner cushion 107.1 illustrated in Fig . 12.
  • the sutures 101.1 are coiled around the wire rail 107.3 on the inner surface of the prosthetic heart valve 100, whilst on the outer surface of the biological prosthetic heart valve, the sutures 101.1 are attached to a retaining arch 16a, 16b, 16c by means of a suitable stitch pattern.
  • the wire rail 107.3 is mounted to the inner surface of the bendable transition area 104 of the prosthetic heart valve.
  • the wire rail 107.3 is preferably made of Nitinol, thus allowing for the wire rail 107.3 to collapse together with the stent 10.
  • the reinforcement element of the third embodiment is designed with rounded edges to avoid abrasion of the leaflet tissue during opening and closing of the prosthetic heart valve 100.
  • Fig. 14 is a cross sectional view along the line A-A shown in Fig . 6b or l ib for explaining a fourth exemplary embodiment of reinforcement elements which may be utilized in the endoprosthesis 1 according to the present disclosure.
  • the reinforcement element instead of using inner cushions 107.1, 107.2 which consist of materials like polyester velour or PTFE, the reinforcement element, according to the fourth exemplary embodiment, can be arranged as essential copies of the retaining arches 16a, 16b, 16c.
  • the reinforcement element is an inner attachment rail 107.4 which is thinner than a corresponding retaining arch 16a, 16b, 16c since a thick material would inhibit the endoprosthesis 1 from being collapsed to a small size.
  • the inner attachment rail 107.4 has the same fastening holes 12a and notches longitudinally distributed at given locations as the corresponding retaining arch 16a, 16b, 16c.
  • the inner attachment rail 107.4 is placed on the inner surface of the tissue material of the prosthetic heart valve 100, opposite to the retaining arches 16a, 16b, 16c.
  • the prosthetic heart valve 100 is clamped in between the retaining arches 16a, 16b, 16c and the inner attachment rail 107.4, wherein the retaining arches 16a, 16b, 16c and the inner attachment rail 107.4 are connected by means of sutures 101.1.
  • the connection between retaining arches 16 and the inner attachment rail 107.4 may utilize rivets, welding or soldering, so as to clamp the biological prosthetic heart valve tissue without penetrating it with needles or suture.
  • the inner attachment rail 107.4 may be made of Nitinol, in order to allow simultaneously collapsing with the stent 10.
  • edges of the inner attachment rail 107.4 may be rounded in order to prevent abrasion of the leaflets 102.
  • the inner attachment rail 107.4 could be wrapped in tissue or synthetic material to further reduce the potential wear during the contact with the leaflet material upon the heart valve operation.
  • Fig. 16 shows a cross sectional view along the line B-B shown in Fig . 6b or l ib for explaining a fifth exemplary embodiment of reinforcement elements which may be utilized in the endoprosthesis 1 of the present disclosure.
  • the reinforcement element is an outer wrapping element 107.5 attached to the back side of the prosthetic heart valve tissue, at the commissure attachment region l i b of the stent 10.
  • the leaflets 102 are folded without forming a cavity. Rather, the outer wrapping element 107.5 is clamped on the outer surface of the biological prosthetic heart valve 100, more particularly to the outer surface of the bendable transition area 104, pressing the leaflets 102 together. Thereby, a strengthened region is created by folding the prosthetic heart valve tissue and wrapping it with the outer wrapping element 107.5.
  • the outer wrapping element 107.5 is attached the commissure attachment region l ib by means of sutures 101.1. Additional lateral sutures 101.2 are provided to press the outer wrapping element 107.5 onto the outer surface of the bendable transition area 104 of the prosthetic heart valve 100.
  • the outer wrapping element 107.5 is preferably made of a polymer material such as PTFE, PET fabric or sheet or a piece of pericardial tissue. However, it could also be a more rigid u-shaped clip or bendable material that can pinch the folded tissue material of the prosthetic heart valve 100 without the use of additional lateral sutures 101.2. In addition, this outer wrapping element 107.5 acts as a bumper to limit the opening of the leaflets 102 in order to prevent them from hitting stent 10.
  • the dashed lines in Fig . 16 represent the closed position of the leaflets 102.
  • Fig. 18 shows an alternative attachment solution where the prosthetic heart valve 100 is mounted to the stent 10 from the outside.
  • the tissue material of the prosthetic heart valve 100 is folded and passes through slots 110 provided in the retaining arches 16a, 16b, 16c.
  • the edges of the slots 110 are preferably rounded and smooth to avoid abrading or wearing the tissue material of the prosthetic heart valve 100.
  • the slots 110 could be wrapped in thin pericardial tissue. In this design, there is some material thickness on the outside of the stent 10, which could impinge on the anchoring of the stent 10 at the position of the diseased natural prosthetic heart valve.
  • One embodiment might include thinning the retaining arches 16a, 16b, 16c on the outer surface relative to the rest of the stent structure, to accommodate the tissue material on the outside surface. This would also allow for a recess when the stent 10 is compressed so that the collapsed prosthesis does not require a larger delivery catheter.
  • Fig. 17 is a cross sectional view along the line B-B depicted in Fig. 6b or l i b showing a sixth exemplary embodiment of reinforcement elements 107.6, 107.7 which may be utilized in the endoprosthesis according present disclosure.
  • Fig . 17 shows an embodiment where reinforcement elements 107.6 and 107.7 are attached to the inner surface and the outer surface of the transition area 104 of the prosthetic heart valve 100.
  • Fig. 17 only shows a cross sectional view along the line B-B, it should be noted that the depicted sixth embodiment of the reinforcement elements may also be applied along the retaining arches 16a, 16b, 16c (line A-A) of the stent.
  • the outer reinforcement element 107.6 may consist of a wide strip of 200 ⁇ thick porcine pericardium that is long enough to cover the entire length of the retaining arches 16a, 16b, 16c (lower leaflet attachment region 11c) and the commissure attachment region l ib.
  • This strip of pericardium which forms the outer reinforcement element 107.6 can be cut into three short segments of about 5 mm each to match the length of the
  • the 4 mm wide porcine pericardium outer reinforcement element 107.6 may be folded in half and sutured using a fine clinging suture 101. 4 (e. g. a 8-0 suture) with a running stitch very close to the free edges.
  • the sutured outer reinforcement element 107.6 is then placed along the inner surface of the retaining arches 16a, 16b, 16c and/or the commissure attachment region l ib with a 8-0 running stitch placed along the stent surface.
  • the outer reinforcement element 107.6 is sutured to the stent to line the inner surface using 6-0 surrounding sutures 101.3 and zig-zag crossing stitches that wrap around the commissure attachment region l ib and/or the retaining arches 16a, 16b, 16c (not through the eyelets).
  • the material is preferably a strip of 200 ⁇ porcine pericardium, which is about 3.5 mm wide and cut and overlapped or rolled to three layers.
  • the length of the piece of tissue depends on whether only the commissure attachment region l ib or the retaining arches 16a, 16b, 16c are reinforced .
  • the strip is held in the overlapped or rolled shape by clinging sutures 101.4 with an 8-0 running stitch.
  • the inner reinforcement element 107.7 may be constructed such as to exhibit minimal size to avoid causing too big of a cavity 109 in between the leaflets 102 during closure of the prosthetic heart valve 100.
  • the inner reinforcement element 107.7 is secured on the inner surface of the bendable transition area 104 of the prosthetic heart valve 100 and to the stent 10 through the eyelets 12a.
  • 4-0 sutures 101.1 with a locking stitch on the outer diameter are used for this purpose. These sutures 101.1 are the most critical in the assembly and need to be very tight with no slack and locking. Instead of a single 4-0 suture 101.1, it is contemplated that two 6-0 sutures for redundancy and similar overall total strength are used. Furthermore, the 4-0 sutures 101.1 hold the outer reinforcement element 107.6 in place.
  • the outer reinforcement element 107.6 acts as a bumper to absorb shocks which affect the leaflets 102 during opening .
  • the inner reinforcement element 107.7 spreads out the compressive forces induced by the sutures 101.1, thus avoiding stress concentration at the transition area 104 of the prosthetic heart valve 100.
  • FIG. 7a shows a first perspective side view of a transcatheter delivered endoprosthesis 1 for treating a narrowed cardiac valve or a cardiac valve insufficiency, where the endoprosthesis 1 comprises a cardiac valve stent 10 according to the first exemplary embodiment of the stent (Figs. 5a-e) for holding a prosthetic heart valve.
  • Fig. 7b shows a second perspective side view of the endoprosthesis 1 depicted in Fig . 7a.
  • Figs 7a, b shows the prosthetic heart valve 100 according to the second valve embodiment. That is, the prosthetic heart valve 100 attached to the stent 10 of Figs. 7a, b consists of three separate pieces 120 being sewn together along their contiguous edges 112. These three separate pieces 120 may either be cut from a single pericardial sack (xenograft or homograft) or from a plurality of pericardial sacks.
  • the endoprosthesis 1 according to the exemplary embodiment illustrated by Figs. 7a and 7b comprises a stent 10 according to the first stent embodiment depicted by Figs. 5a to 5e.
  • This stent 10 comprises a plurality of positioning arches 15a, 15b, 15c configured to be positioned within a plurality of pockets of the patient's native heart valve and positioned on a first side of a plurality of native heart valve leaflets, and a plurality of retaining arches 16a, 16b, 16c configured to be positioned on a second side of the plurality of native heart valve leaflets opposite the first side, wherein furthermore a plurality of leaflet guard arches 50a, 50b, 50c are provided, each interspaced between the two arms 15a', 15a", 15b', 15b", 15c', 15c" of one of the plurality of positioning arches 15a, 15b, 15c.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c are preferably provided with a plurality of bending edges 33 in order to divide each arm 16a', 16a", 16b', 16b", 16c', 16c" into a plurality of arm segments, wherein the structure of the stent 10 is programmed such that the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c have a curved shape at least in the expanded state of the stent 10.
  • the shape of the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c shall be such defined that the arms follow the shape of the leaflets 102 of a prosthetic heart valve 100 to be affixed to the stent 10.
  • one leaflet guard arch 50a, 50b, 50c is provided in between each
  • one leaflet guard arch 50a, 50b, 50c is allocated to each positioning arch 15a, 15b, 15c.
  • Each leaflet guard arch 50a, 50b, 50c has a substantially U-shaped or V-shaped structure which is closed to the lower end 2 of the stent 10.
  • each leaflet guard arch 50a, 50b, 50c has a shape that is roughly similar to the shape of the positioning arch 15a, 15b, 15c and each leaflet guard arch 50a, 50b, 50c is arranged within the arms of the corresponding positioning arch 15a, 15b, 15c.
  • each of the leaflet guard arches 50a, 50b, 50c extends in the same direction as the positioning arch 15a, 15b, 15c.
  • the leaflet guard arches 50a, 50b, 50c are preferably programmed so that they extend in a radial direction outside the circumference of the stent 10 when the stent 10 is in its expanded state. In this way, an increased contact force can be applied to the leaflets of the native (diseased) cardiac valve when the stent 10 is in its expanded and implanted state. This, in turn, allows an increased security in the fixing of the stent 10 in situ .
  • the leaflet guard arches 50a, 50b, 50c actively keep the diseased leaflets, i.e. the leaflets of the native cardiac valve, from impinging the leaflets 102 of a prosthetic heart valve 100 attached to the stent 10, when the positioning arches 15a, 15b, 15c are placed outside the native leaflets.
  • the leaflet guard arches 50a, 50b, 50c may also provide additional anchoring and securing against migration.
  • FIGs. 8a-d An alternative embodiment of a stent 10 is shown in Figs. 8a-d (hereinafter also named "second stent embodiment").
  • the stent 10 according to the embodiment depicted in Figs. 8a-d essentially comprises the same features as the stent described with reference to Figs. 5a-e.
  • the stent 10 also comprises positioning arches 15a, 15b, 15c as well as retaining arches 16a, 16b, 16c and an annular collar 40.
  • the stent 10 of the second stent embodiment comprises retaining arches 16a, 16b, 16c which are not provided with a number of lower leaflet attachment regions 11c, each having a number of additional fastening holes 12a or eyelets provided for fastening the tissue components of a prosthetic heart valve 100.
  • the stent of the second stent embodiment is provided with retaining arches 16a, 16b, 16c whose arms 16a', 16a", 16b', 16b", 16c', 16c" are segmented by a plurality of bending edges 33 which are not only used for defining a bending point of two neighboring arm segments, but also as fastening notches which can be used for fixing the prosthetic heart valve prosthesis 100 to the stent 10.
  • the fastening notches are adapted to the thickness of the suture, thread or wire.
  • the additional notches may be radiused to minimize damage to the suture, thread or wire.
  • the retaining arches 16a, 16b, 16c allow for more continuous bending along the entire length of their respective arms 16a', 16a", 16b', 16b", 16c', 16c", simplifying the attachment of said retaining arches 16a, 16b, 16c to the bendable transition area 104 of the prosthetic heart valve 100.
  • Fig. 8a shows a flat roll-out view of a cardiac valve stent 10 pursuant the second embodiment of the stent 10, whereby the stent 10 is in its non- expanded state.
  • This flat roll-out view corresponds to a two-dimensional projection of a cutting pattern which can be used in the manufacture of the stent 10 pursuant the second embodiment.
  • Fig. 8b shows a first perspective side view of a cardiac valve stent 10 according to the second stent embodiment, whereby the cardiac valve stent 10 is shown in its expanded state
  • Fig. 8c shows a second perspective side view the stent 10 according to the second stent embodiment, whereby the cardiac valve stent is also shown in its expanded state.
  • Fig. 8d shows a flat roll-out view of a cardiac valve stent 10 according to the second embodiment of the stent. Contrary to the flat roll-out view depicted in Fig. 8a, however, the flat roll-out view according to Fig . 8d shows the cardiac valve stent 10 is in its expanded state.
  • the stent 10 comprises a plurality of positioning arches 15a, 15b, 15c and a plurality of retaining arches 16a, 16b, 16c.
  • Each of the plurality of positioning arches 15a, 15b, 15c is configured to be positioned within a plurality of pockets of the patient's native heart valve and positioned on a first side of a plurality of native heart valve leaflets.
  • each of the plurality of retaining arches 16a, 16b, 16c is configured to be positioned on a second side of the plurality of native heart valve leaflets opposite the first side.
  • leaflet guard arches 50a, 50b, 50c are provided, each interspaced between the two arms 15a', 15a", 15b', 15b", 15c', 15c" of one of the plurality of positioning arches 15a, 15b, 15c.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c are preferably provided with a plurality of bending edges 33 in order to divide each arm 16a', 16a", 16b', 16b", 16c', 16c" into a plurality of arm segments, wherein the structure of the stent 10 is programmed such that the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c have a curved shape at least in the expanded state of the stent 10.
  • the shape of the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c shall be such defined that the arms follow the shape of the bendable transition area 104 of the prosthetic heart valve 100 to be affixed to the stent 10.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c are provided with a plurality of bending edges 33.
  • These bending edges 33 may be uniformly distributed along the length of each retaining arch arm 16a', 16a", 16b', 16b", 16c', 16c" thereby dividing each arm 16a', 16a", 16b', 16b", 16c', 16c” into a plurality of arm segments.
  • the arm segments of a corresponding retaining arch arm 16a', 16a", 16b', 16b", 16c', 16c” are interconnected thereby constituting a retaining arch arm which describes an essentially straight line in the not-expanded state of the stent 10.
  • Fig . 8a which shows the uncurved configuration of the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c.
  • the stent structure and in particular the structure of the retaining arches 16a, 16b, 16c is programmed such that the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c" have a curved shape in the expanded state of the stent 10.
  • the shape of the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c" is such defined that the arms follow the shape of the leaflets of a prosthetic heart valve 100 to be affixed to the stent 10 (cf. Fig. 8d).
  • the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c", onto which the prosthetic heart valve 100 is sewn or sewable will change their shape when the stent 10 expands, wherein the retaining arches 16a, 16b, 16c are curved in the expanded state of the stent 10, but relatively straight when the stent 10 is collapsed.
  • the retaining arches 16a, 16b, 16c of the stent 10 are adapted to fit to the shape of the bendable transition area 104 of the prosthetic heart valve 100.
  • the retaining arches 16a, 16b, 16c are adapted to progress in an essentially u-shaped manner, similar to the shape of a natural aortic or pulmonary heart valve, for reducing tissue stresses during the opening and closing motion of the leaflets 102.
  • the essentially u-shaped curvature of the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c" is achieved by segmenting the arms 16a', 16a", 16b', 16b", 16c', 16c".
  • the arms 16a', 16a", 16b', 16b", 16c', 16c" are segmented by providing a plurality of bending edges 33.
  • two neighboring arm segments are angled relative to each other, wherein the bending point of these two neighboring arm segments is defined by the bending edge 33 which is provided in between neighboring arm segments.
  • the greater the number of bending edges 33 provided in an arm 16a', 16a", 16b', 16b", 16c', 16c" of a retaining arch 16a, 16b, 16c the greater the number of arm segments which may extend in different directions in the expanded state of the stent 10.
  • the shape of the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c" can be adapted to the shape of the leaflets 102 of the prosthetic heart valve 100 to be affixed to the stent 10.
  • the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c are not provided with fastening holes 12a, as it is the case, for example, in the first embodiment of the stent (Figs. 5a to 5e).
  • the bending edges 33 provided in the retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c" are not only used for defining a bending point of two neighboring arm segments, but also as fastening notches which can be used for fixing a prosthetic heart valve 100 to the stent 10.
  • FIG. 5a A comparison with, for example, the flat roll-out view pursuant to Fig. 5a (first stent embodiment) illustrates directly that the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c" of the stent design according to the second stent embodiment is at least partly much more thinner compared with the respective retaining arch arms of the first stent embodiment which are provided with lower leaflet attachment regions having fastening holes 12a.
  • the bendability of the arms is increased which allows a more precise adaptation of the shape of the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c” to the shape of the bendable transition area 104 of the prosthetic heart valve 100 to be affixed to the stent 10.
  • the fastening notches provide space and allow for the sutures 101 to be protected during collapsing of the valve 100 into the catheter.
  • the attachment points (bending edges 33) to be used for fixing a heart valve prosthesis to the retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c" of the stent 10 are more uniformly distributed along the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c", thereby providing a more uniform fixation of a heart valve prosthesis to the stent.
  • Each individual bending edge 30 provided in the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c" thereby serves to guide a thread or thin wire with which the tissue component(s) of the prosthetic heart valve is affixed or sewn to the corresponding retaining arch arm 16a', 16a", 16b', 16b", 16c', 16c" of the stent 10.
  • the means (thread or thin wire) provided for fastening the tissue component(s) of the prosthetic heart valve to the respective retaining arch arms 16a', 16a", 16b', 16b", 16c', 16c" is guided by way of the bending edge 33 acting as fastening notch so that a longitudinal displacement of the prosthetic heart valve relative to the stent 10 is substantially minimized .
  • This also allows exact positioning of the prosthetic heart valve relative the stent 10.
  • the stent 10 according to the second stent embodiment may further include at least one auxiliary arch 18a, 18b, 18c interspaced between two adjacent retaining arches 16a, 16b, 16c, wherein the at least one auxiliary arch 18a, 18b, 18c includes a first arm 18a', 18b', 18c' connected at a first end thereof to a first retaining arch 16a, 16b, 16c and a second arm 18a", 18b", 18c" connected at a first end thereof to a second retaining arch 16a, 16b, 16c, and wherein the first and second arms 18a', 18a", 18b', 18b", 18c', 18c" of the at least one auxiliary arch 18a, 18b, 18c each include respective second ends connected to an annular collar 40 which is arranged at the lower end section of the stent body.
  • this at least one collar 40 serves as an additional anchoring measure for a stent cut from a portion of a tube by using the cutting pattern depicted in Fig . 8a.
  • the respective first and second arms 18a', 18a", 18b', 18b", 18c', 18c" of the at least one auxiliary arch 18a, 18b, 18c are part of a strut or web structure which is provided between the first and second arms 18a', 18a", 18b', 18b", 18c', 18c" of two adjacent auxiliary arches 18a, 18b, 18c in order to support the prosthetic heart valve 100 to be affixed to the stent 10 (see, for example, Figs.
  • the strut or web structure may be composed by a plurality of struts or strut-like members which are interconnected such as to form a reinforcement structure.
  • Each strut or strut-like element of the reinforcement structure serves as reinforcement member in order to increase the strength or resistance to deformation of the area between the first and second arms 18a', 18a", 18b', 18b", 18c', 18c" of two adjacent auxiliary arches 18a, 18b, 18c.
  • the reinforcement structure thereby provides mechanical reinforcement to the stent 10.
  • the reinforcement members of the reinforcement structure between the first and second arms 18a', 18a", 18b', 18b", 18c', 18c" of two adjacent auxiliary arches 18a, 18b, 18c provides for an additional support for the skirt portion 103 of a prosthetic heart valve 100 to be attached to the stent 10.
  • the terms “strength” or “resistance to deformation” as used herein may be used to denote any of a number of different properties associated with the reinforcement members.
  • the terms may be used to refer to properties of the material from which the reinforcement members are made, such as the yield strength, the modulus of elasticity, the modulus of rigidity, or the elongation percentage.
  • the terms may be used to refer to the hardness of the reinforcement members. Hardness may be characterized as the "durometer" of the material, in reference to the apparatus used to measure the hardness of the material . The terms may also be used to denote geometric characteristics of the reinforcement members, such as the thickness of the reinforcement members. The terms
  • stress or “resistance to deformation” may also be used to characterize any combination of the above properties as well as additional properties and/or characteristics.
  • the strength or resistance to deformation of the area between the first and second arms 18a', 18a", 18b', 18b", 18c', 18c" of two adjacent auxiliary arches 18a, 18b, 18c can be increased in any number of ways. As can be seen from Fig . 8d, the strength or resistance to deformation of the area between the first and second arms 18a', 18a", 18b', 18b", 18c', 18c" of two adjacent auxiliary arches 18a, 18b, 18c can be increased, for example, by providing a reinforcement structure formed by at least one, and preferably by a plurality of reinforcement elements (e.g. struts or strut-like members) which are interconnected to each other.
  • reinforcement elements e.g. struts or strut-like members
  • a reinforcement web is provided in order to increase the strength or resistance to deformation of the area between the first and second arms 18a', 18a", 18b', 18b", 18c', 18c" of two adjacent auxiliary arches 18a, 18b, 18c.
  • This reinforcement web may also be composed by a plurality of reinforcement elements (e.g. struts or strut-like members) which are interconnected to each other thereby forming a rhomboidal pattern.
  • the strength or resistance to deformation of the area between the first and second arms 18a', 18a", 18b', 18b", 18c', 18c" of two adjacent auxiliary arches 18a, 18b, 18c can be increased, for example, by increasing the thickness of the reinforcement members, by eliminating stress concentration risers in the design of the stent 10, or by changing other aspects of the geometry of the reinforcement members.
  • the strength can also be increased by changing the material properties of the stent 10 and/or the reinforcement members.
  • the reinforcement members can be made from a number of different materials, preferably shape memory materials, each having a different level of hardness.
  • the stoichiometric composition of the material used for forming the stent and the reinforcement members such as to adapt the material properties of the stent 10 and/or the reinforcement members to the specific needs of each stent application. It is also conceivable to use different materials, for example nitinol and a shape- memory polymer, for forming the stent and the reinforcement members. In this manner, the selection of the reinforcement members can be tailored to the specific needs of each stent application. For example, in regions where a high external force is expected, reinforcement members having a high hardness may be preferred . The strength may also be increased by combining material properties with geometric changes.
  • a reinforcement structure which is constituted by a plurality of lattice cells 70 formed by a plurality of struts in the area between the arms 16a', 16a", 16b', 16b", 16c', 16c" of two neighbouring (adjacent) retaining arches 16a, 16b, 16c, thereby providing for an additional support for the bendable transition area 104 of a prosthetic heart valve 100 to be attached to the stent 10.
  • this structure of the lattice cells 70 formed by a plurality of struts in the area between the adjacent arms of two neighbouring retaining arches 16a, 16b, 16c may provide uniform stent structure which may minimize blood leakage in the implanted stage of the stent 10 having a heart valve prosthesis attached thereto.
  • the upper end sections of the respective struts which are forming the structure of the lattice cells 70 are connected to the respective arms of the retaining arches 16a, 16b, 16c.
  • the upper end sections of the struts comprise a widened diameter in order to strengthen the connection between the upper end sections of the struts and the arms of the retaining arches 16a, 16b, 16c.
  • the already mentioned annular collar 40 which is provided at the lower end section of the stent body, is connected with the stent body via the retaining arches 16a, 16b, 16c on the one hand and the second ends of the respective arms 18a', 18a", 18b', 18b", 18c', 18c" of the at least one auxiliary arch 18a, 18b, 18c on the other hand, wherein these arms 18a', 18a", 18b', 18b", 18c', 18c" of the at least one auxiliary arch 18a, 18b, 18c are part of the structure of the lattice cells 70.
  • the stent 10 according to the second embodiment is provided with an annular collar 40 which is shortened in its length by having only a single row of cells.
  • the annular collar 40 at the lower end section of the stent body exhibits a plurality of supporting webs 41 which run parallel to the longitudinal axis L of the stent 10 in the non-expanded state of the stent 10 and are inter-connected by transversal webs 42.
  • the supporting webs 41 and the transversal webs 42 forms a rhomboidal or serpentine-like annular collar 40 which abuts against the vascular wall in the implanted state of the stent 10.
  • the stent 10 according to the second stent embodiment is provided with a flared or tapered section with a radius shape at its lower end section 2.
  • the lower end section of the annular collar 40 constitutes the flared or tapered section of the stent 10.
  • the prosthetic heart valve 100 according to the present disclosure may comprise a flared or tapered lower end section so as to fit to the described stent shapes.
  • the stent 10 depicted in Figs. 8b and 8c has at its lower end section 2 a flared or tapered section with a radius shape; however, it is also conceivable that the flared or tapered section is not uniformly around the circumference of the stent 10.
  • the stent 10 may have a flare only near the locations of the positioning arches 15a, 15b, 15c, wherein no flare is provided near the commissure regions, i.e. the regions in between the two arms 15a', 15a", 15b', 15b", 15c', 15c" of two neighboring positioning arches 15a, 15b, 15c.
  • embodiment comprises a continuous design of its lower end section 2. Due to this continuous design, in the implanted and expanded state of the stent 10, via the lower end section 2 of the stent 10 an uniform radial force is applied to the wall of the blood vessel into which the stent 10 is deployed . If the implanted and expanded stent together with a prosthetic heart valve affixed thereto extend too far below the annulus of the heart, there may be the risk that the implanted endoprosthesis consisting of the stent 10 on the one hand and the prosthetic heart valve 100 on the other hand contacts the nerve bundles and heart block. The nerve bundles may enter at a location approximately 6 to 10 mm below the annulus of the heart.
  • the stent 10 pursuant to the second stent embodiment is provided with an annular collar 40 which is shortened in its length by having only a single row of cells. In this regard, the total height of the stent 10 and thus the total height of the endoprosthesis 1 to be implanted into the body of the patient are reduced.
  • the supporting webs 41 of the annular collar 40 may be programmed so that - when the stent 10 of the second embodiment is in its expanded state - only the upper section of the annular collar 40 extends in a radial direction outside the circumference of the stent 10, whereas the lower end section of the annular collar 40 bended relative to the upper section of the annular collar 40 in the radial direction inside the circumference of the stent 10.
  • the lower end section of the annular collar 40 may be bent such that it extends, for example, approximately parallel to the longitudinal direction L of the stent 10.
  • the stent 10 according to the second stent embodiment comprises a number of notches 12e uniformly distributed around the lower end section of the annular collar 40. These notches 12e can be used for fixing a heart valve prosthesis (not shown in Figs. 8b and 8c) to the stent 10, which may reduce the risk of an axial displacement of the heart valve prosthesis 100 relative to the stent 10.
  • the stent 10 Since it is conceivable for the stent 10 to exhibit a structure integrally cut from a portion of tube, in particular from a metal tube, which incorporates all structural components of the stent 10, in particular the positioning arches 15a, 15b, 15c, the retaining arches 16a, 16b, 16c and the annular collar 40 with defined additional fastening means at the lower end thereof, an elaborate cutting pattern for forming the design of the stent 10 from the original tube portion is important. In particular, it must be taken into account that the structure of the stent 10 with all structural stent components must be cut from the limited lateral area of the original tube portion.
  • the stent design according to the second stent embodiment differs from the first stent design in that at the lower end section of every supporting web 41 of the annular collar 40 an additional fastening means is provided. This is due to the fact that, in the second embodiment of the stent 10, notches 12e are used as additional fastening means.
  • the additional fastening means to be used for fixing a heart valve prosthesis to the stent 10 are more uniformly distributed around the lower end section of the annular collar 40, thereby providing a more uniform fixation of a prosthetic heart valve to the stent.
  • the risk of an axial displacement of the heart valve prosthesis relative to the stent may be further reduced.
  • Each individual notch 12e provided at the lower end section of the annular collar 40 thereby serves to guide a thread or thin wire with which the tissue component(s) of the prosthetic heart valve is affixed or sewn to the lower end section of the annular collar 40 of the stent 10.
  • the means (thread or thin wire) provided for fastening the tissue component(s) of the prosthetic heart valve 100 to the lower end section of the annular collar 40 is guided by way of the notches 12e so that a longitudinal displacement of the prosthetic heart valve relative to the stent 10 is substantially minimized .
  • This also allows positioning of the prosthetic heart valve relative the stent 10.
  • the prosthetic heart valve 100 may further comprise an essentially zig-zag shaped pattern at a lower end section.
  • the means (threads or thin wires) used to fasten the tissue component(s) to the stent 10 are effectively prevented from being squeezed and thus degraded when the stent 10 with the prosthetic heart valve affixed thereto, i.e. the endoprosthesis 1, is compressed and brought into its collapsed shape such as to be ready for being inserted into a catheter system which is used for implanting the endoprosthesis 1.
  • the cross-sectional shape of the notches 12e may be adapted to the cross-sectional shape of the thread or thin wire used to fasten the tissue component(s) of the prosthetic heart valve 100. This allows fixing of the tissue component(s) of the prosthetic heart valve 100 to the stent 10 at a precise predefined position relative to the stent 10.
  • the fastening holes 12 are adapted to the thickness and/or the cross-sectional shape of the thread or thin wire used to affix the prosthetic heart valve 100 to the stent 10, relative movement between the stent 10 and the tissue component(s) of the prosthetic heart valve 100 due to the peristaltic motion of the heart can be effectively prevented when the endoprosthesis 1 is implanted .
  • the tissue component(s) of the prosthetic heart valve 100 is/are thus fastened to the stent 10 with minimal play, based on which friction-induced wear of the thread or thin wire used to affix the prosthetic heart valve is minimized .
  • the notches 12e have a semi-circular cross-sectional shape.
  • the stent 10 according to the second stent embodiment of the invention may further comprise at least one radial arch 32a, 32b, 32c which enables a particularly secure anchoring of the stent 10 in the site of implantation in the heart and which is substantially circumferentially aligned with at least one of the plurality of positioning arches 15a, 15b, 15c.
  • the stent 10 is further provided with a total of three leaflet guard arches 50a, 50b, 50c, each comprising two leaflet guard arms. It can be seen from the flat roll-out view shown in Fig.
  • a leaflet guard arch 50a, 50b, 50c is provided in between each positioning arch 15a, 15b, 15c.
  • a leaflet guard arch 50a, 50b, 50c is allocated to each positioning arch 15a, 15b, 15c.
  • the radial arches 32a, 32b, 32c of the stent 10 according to the second stent embodiment extend from the leaflet guard arches 50a, 50b, 50c towards the upper end 3 of the stent 10. As is shown most clearly in Fig .
  • the stent 10 has three radial arches 32a, 32b, 32c, with each arch 32a, 32b, 32c located between the two arms of each leaflet guard arch 50a, 50b, 50c.
  • Each radial arch 32a, 32b, 32c has a shape that is roughly inverse to each positioning arch 15a, 15b, 15c and extends in the opposite direction to each one of the positioning arches 15a, 15b, 15c.
  • each leaflet guard arch 50a, 50b, 50c has a substantially U- shaped or V-shaped structure which is closed to the lower end 2 of stent.
  • each leaflet guard arch 50a, 50b, 50c has a shape that is roughly similar to the shape of the positioning arch 15a, 15b, 15c in between the corresponding leaflet guard arch 50a, 50b, 50c is arranged. Furthermore, each leaflet guard arch 50a, 50b, 50c extends in the same direction as the positioning arch 15a, 15b, 15c.
  • each arm of a leaflet guard arch 50a, 50b, 50c merges at about the mid-point of the length of an arm of a radial arch 32a, 32b, 32c into the arm of an opposing radial arch 32a, 32b, 32c.
  • the leaflet guard arches 50a, 50b, 50c project in the longitudinal direction L of the stent and have a reduced length such that the positioning arches 15a, 15b, 15c can deploy during the expansion of the stent 10 and the leaflet guard arches 50a, 50b, 50c do not interfere during deployment.
  • the positioning arches 15a, 15b, 15c disposed on the stent 10 and also the retaining arches 16a, 16b, 16c may be curved in convex and arched fashion in the direction to the lower end section of the stent; i.e. toward the lower end 2 of the stent, whereby such a rounded form may reduce injuries to the artery as well as facilitate the unfolding during the self-expansion.
  • Such a design may enable an easier insertion of the positioning arches 15a, 15b, 15c into the pockets of the native cardiac valve without correspondingly injuring the neighbouring tissue or blood vessels.
  • the leaflet guard arches 50a, 50b, 50c are preferably programmed so that they extend in a radial direction outside the circumference of the stent 10 when the stent 10 of the second stent embodiment is in its expanded state. In this way, an increased contact force can be applied to the leaflets of the native
  • the leaflet guard arches 50a, 50b, 50c actively keep the diseased leaflets, i.e. the leaflets of the native cardiac valve, from impinging the leaflet tissue of the prosthetic heart valve 100 attached to the stent 10, when the positioning arches 15a, 15b, 15c are placed outside the native leaflets.
  • the leaflet guard arches 50a, 50b, 50c may also provide additional anchoring and securing against migration. This feature may be unique compared to the cage known from the prior art stent designs which are not provided with positioning arches to push the diseased leaflets out of the way.
  • each radial arch 32a, 32b, 32c are connected together at the upper end 3 of the stent 10 by means of a radiused connecting portion or head.
  • This head is not only radiused but also widens at the tip so that the head abuts against the interior wall of the vessel over as large a contact area as possible when the stent 10 is in its expanded and implanted state.
  • the heads of each radial arch 32a, 32b, 32c may also serve as additional means by which the stent 10 may be retained in a catheter before and during implantation and/or to recapture the stent after implantation.
  • the radial arches 32a, 32b, 32c are programmed so that they extend in a radial direction outside the circumference of the stent 10 when the stent 10 is in its expanded state. In this way an increased contact force can be applied to the vessel wall by the upper end region of the stent 10. This, in turn, allows an increased security in the fixing of the stent 10 in situ, thereby reducing the likelihood of migration of the stent 10.
  • the stent 10 of the second stent embodiment is secured in place on implantation via radial forces exerted by the retaining arches 16a, 16b, 16c, the auxiliary arches 18a, 18b, 18c, the radial arches 32a, 32b, 32c, and the annular collar 40, all of which project outwards in a radial direction from the circumference of the stent 10.
  • the radial arches 32a, 32b, 32c do not project in the longitudinal direction L of the stent 10 beyond the plane in which the catheter retaining means 23 or the fastening means with fastening eyelets 24 are situated .
  • This may ensure that the catheter retaining means 23 can co-operate with corresponding means within a suitable implantation catheter without interference from the heads of the radial arches 32a, 32b, 32c.
  • the heads themselves can be used as additional catheter retaining means or additional means to effect explanation of the stent 10.
  • the stent 10 may have more than three radial arches 32 in order to increase the radial contact force further. It is also possible to provide barb elements on all or some of the radial arches 32a, 32b, 32c, for example, to allow a still better anchoring of the stent 10 at the implantation site.
  • the stent 10 comprises barb members arranged, for example, on the eyelets 24, the tips of the barbs pointing toward the lower end 2 of stent 10.
  • a liner or sheath typically a fabric, polymeric or pericardial sheet, membrane, or the like, may be provided over at least a portion of the exterior of the stent 10 to cover all or most of the surface of the outside of the stent 10, extending from a location near the lower end section of the stent to a location near the upper end section of the stent.
  • the liner may be attached to the stent 10 at at least one end, as well as at a plurality of locations between said ends thereby forming an exterior coverage.
  • Such exterior coverage provides a circumferential seal against the inner wall of the blood vessel lumen in order to inhibit leakage of blood flow between the stent 10 and the luminal wall thereby and to prevent a blood flow bypassing the endoprosthesis 1.
  • the liner may be stitched or otherwise secured to the stent 10 along a plurality of circumferentially spaced-apart axial lines. Such attachment permits the liner to fold along a plurality of axial fold lines when the stent 10 is radially compressed.
  • the liner will further be able to open and conform to the luminal wall of the tubular frame as the frame expands.
  • the liner may heat welded, or ultrasonically welded to the stent 10.
  • the liner may be secured to the plurality of independent arches (positioning arches 15a, 15b, 15c, retaining arches 16a, 16b, 16c, auxiliary arches 18a, 18b, 18c, leaflet guard arches 50a, 50b, 50c) preferably along axial lines.
  • the liner may be secured to the annular collar 40 provided at the lower end section 2 of the stent 10.
  • the liner will preferably be circumferentially sealed against the stent 10 at at least one end .
  • the stent 10 can be compressed from a relaxed, large diameter configuration to a small diameter configuration to facilitate introduction. It is necessary, of course, that the outer liner remain attached to the stent 10 both in its radially compressed configuration and in its expanded, relaxed configuration.
  • the liner is composed of pericardial material or conventional biological graft materials, such as polyesters, polytetrafluoroethylenes (PTFE's), polyurethanes, and the like, usually being in the form of woven fabrics, non-woven fabrics, polymeric sheets, membranes, and the like.
  • a presently preferred fabric liner material is a plain woven polyester, such as Dacron® yarn (Dupont, Wilmington, Delaware).
  • the third embodiment of the stent 10 is similar in structure and function with respect to the second embodiment. To avoid repetition, reference is therefore made to the above description of the second embodiment.
  • the lower end section of the stent 10 is constituted by an annular collar 40 which is likewise provided with notches 12e acting as additional fastening means.
  • the stent 10 according to the third stent embodiment is provided with retaining arches 16a, 16b, 16c whose arms 16a', 16a", 16b', 16b", 16c', 16c" are segmented by a plurality of bending edges 33 which are not only used for defining a bending point of two neighboring arm segments, but also as fastening notches which can be used for fixing a heart valve prosthesis 100 to the stent 10.
  • the retaining arches 16a, 16b, 16c of the third stent embodiment are adapted to extend along the bendable transition area 104 of the prosthetic heart valve, when the endoprosthesis is assembled .
  • the third embodiment of the stent 10 also includes radial arches 32a, 32b, 32c extending from the positioning arches 15a, 15b, 15c towards the upper end 3 of the stent 10.
  • the stent 10 has three radial arches 32a, 32b, 32c, with each arch 32a, 32b, 32c located between the two arms 15a, 15a', 15b, 15b', 15c, 15c' of each positioning arch 15a, 15b, 15c.
  • Each radial arch 32a, 32b, 32c has a shape that is roughly inverse to each positioning arch 15a, 15b, 15c and extends in the opposite direction to each one of the positioning arches 15a, 15b, 15c.
  • each arm of a radial arch 32a, 32b, 32c merges at about the midpoint of the length of the stent 10 into an arm 15a', 15a", 15b', 15b", 15c', 15c" of an opposing positioning arch 15a, 15b, 15c.
  • FIG. 10 is a flat roll-out view of the fourth stent embodiment, whereby the cardiac valve stent 10 is shown in its expanded state.
  • the fourth embodiment of the stent 10 only differs from the second stent
  • the respective lower end sections of the leaflet guard arches 50a, 50b, 50c are removed.
  • the lower end sections of the leaflet guard arches 50a, 50b, 50c between the points where each arm of a radial arch 32a, 32b, 32c merges is removed .
  • FIG. 11a to 11c Another embodiment of an endoprosthesis 1 according to the present disclosure is shown by Figs. 11a to 11c.
  • this third embodiment of an endoprosthesis 1 includes a stent 10 according to the second stent embodiment (Figs. 8a to 8d) and a prosthetic heart valve 100, in accordance with the second heart valve embodiment (Figs. 3 and 4), affixed thereto.
  • Fig. 11a shows a first side view of the third embodiment of the endoprosthesis 1. From this first side view, the characteristic U-shape of the retaining arches 16a, 16b, 16c becomes readily apparent.
  • this U-shape of the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c is achieved by segmenting the arms 16a', 16a", 16b', 16b", 16c', 16c".
  • the arms 16a', 16a", 16b', 16b", 16c', 16c" are segmented by providing a plurality of bending edges 33.
  • two neighboring arm segments are angled relative to each other, wherein the bending point of these two neighboring arm segments is defined by the bending edge 33 which is provided in between the both neighboring arm segments.
  • the shape of the respective arms 16a', 16a", 16b', 16b", 16c', 16c" of the retaining arches 16a, 16b, 16c can be adapted to the shape of transition area 104 of a prosthetic heart valve 100 to be affixed to the stent 10 adapted so as to fit the retaining arches 16a, 16b, 16c to the progression of the bendable transition area 104 of the prosthetic heart valve 100.
  • Fig. 11a shows the bending edges providing a number of fastening notches which are used to fix the bendable transition area 104 to stent 10.
  • the sutures 101 are wrapped around the retaining arches 16a, 16b, 16c and sewn to the bendable transition area 104, whilst being held in place by the fastening notches which extend essentially in the same direction as the bendable transition area 104 of the prosthetic heart valve. That is, the prosthetic heart valve 100 of the present third embodiment of the
  • endoprosthesis 1 is more securely attached to the stent 10 as the fastening notches provide a greater number of attachment points compared with the number of fastening holes 12a, used in the embodiment according to Figs. 6a and 6b of the present disclosure. In this regard, high stress concentrations at each single attachment point can be effectively avoided .
  • Fig. l ib shows the connection between the skirt portion 103 and the
  • This plurality of lattice cells 70 formed by a plurality of struts in the area between the arms 16a', 16a", 16b', 16b", 16c', 16c" of two neighbouring (adjacent) retaining arches 16a, 16b, 16c, provides for an additional support for the bendable transition area 104 of a prosthetic heart valve 100 to be attached to the stent 10.
  • the prosthetic heart valve 100 may be directly sewn to the lattice cells 70 by means of sutures 101, threads or thin wires.
  • the prosthetic heart valve 100 according to the third embodiment of the endoprosthesis 1, comprises three separate pieces 120 being sewn together at their contiguous edges 112.
  • Fig. 11c shows a perspective top view of the third embodiment of the endoprosthesis.
  • Fig. 11c illustrates the attachment of the three separate pieces 120 being sewn together in a cylindrical manner along their contiguous edges 112. After the contiguous edges 112 of the separate pieces 120 are aligned and sewn together, the sleeves 111 of the separate pieces 120 are turned to the outside and attached to the commissural attachment region l i b of the stent 10. A more detailed description of this particular attachment method will be described with reference to Figs 19a-c and 20.
  • this third endoprosthesis embodiment is not meant to be restrictive.
  • a one piece prosthetic heart valve in accordance with the first valve embodiment (Fig. 1) of the present disclosure, to the stent 10 shown in Figs. 8a to 8d .
  • the prosthetic heart valve 100 is generally mounted to the inner surface of the stent 10.
  • the skirt portion 102 could be in direct contact with the diseased native heart valve and could be attached to the stent 10 by means of sutures.
  • Mounting the prosthetic heart valve 100 to the outer surface of the stent 10 supports the load transfer from the leaflet 102 to the stent 10 and reduces the stress concentration near the attachment regions l ib, 11c. This greatly reduces stresses on the leaflets 102 during closing and consequently improves the durability thereof.
  • valve it is possible to design the valve to obtain improved hemodynamics in the case of mounting the skirt portion to the outer surface of the stent.
  • heart valve material which is in direct contact with the diseased native heart valve provides a good interface for sealing against leakage (i.e., paravalvular leakage), tissue in-growth and attachment.
  • An alternative second embodiment of a prosthetic heart valve 100 is shown in Figs. 3 and 4 as well as Figs. 19a-c and 20.
  • Figs. 3 and 4 illustrate a flat pattern of the prosthetic heart valve material, which has an essentially t-shirt like shape.
  • the prosthetic heart valve 100 is made of three separate pieces 120 exhibiting the depicted t-shirt like shape.
  • the three separate pieces 120 are connected to each other at their contiguous edges 112 by suturing, in order to form the cylindrical or conical shape of the prosthetic heart valve 100.
  • the three separate pieces 120 may be cut from more than one pericardial sack, so as to obtain three pieces 120 having matching characteristics, e.g ., tissue thickness and properties.
  • the bendable transition area 104 is implied in the drawing of Fig . 3.
  • each of the separate pieces 120 is intended to represent one of the three leaflets 102 of the prosthetic heart valve 100, in addition to the transition area 104 and skirt portion 103.
  • Fig . 4 shows a top view of the three separate pieces 120 sewn together and attached to a commissure attachment regions l ib of a stent according to the further exemplary embodiment of the disclosure.
  • a first step the contiguous edges 112 are brought together and sleeves 111 of the separate pieces 120 are turned to the outside, as shown in Fig. 19a.
  • a reinforcement element 107.8 may then be attached to the front surface of the sleeves 111 by means of sutures 101.1, preferably applying a blanket stitch.
  • the continuous edges 112 are sewn together by means of the same sutures 101.1, again preferably applying a blanket stitch.
  • the reinforced sleeves 111 are turned even further to the outside, so that they end up being folded rearwards onto the surface of the leaflets 102. This rearward folded position is then secured by means of lateral sutures 101.2 stitched on the outer surface of the reinforcement element 107.8.
  • FIG. 4 A top view of the three separate pieces 120 sewn together and attached to the commissure attachment regions l ib of a stent 10 is illustrated in Fig. 4. As mentioned before, each of the three separated pieces 120 represents one of the three leaflets 102 of the prosthetic heart valve 100.
  • FIG. 20 A detailed perspective view of the attachment of the prosthetic heart valve 100 to the commissure attachment regions l ib of the present embodiment is shown in Fig . 20.
  • the reinforcement element 107.8 is wrapped around the rearward folded sleeves 111. This rearward folded position is held by the lateral suture 101.2 connecting the opposite ends of the reinforcement element 107.8.
  • reinforcement element 107.8 preferably has much higher suturing retention strength than the heart valve material of the three separate pieces 120. For this reason, the reinforcement element 107.8 is used to attach the prosthetic heart valve 100 to the commissure attachment regions l ib of the stent 10, by means of suturing 101.1.
  • stresses due to the suturing 101.1 between the stent 10 and the prosthetic heart valve 100 are mainly introduced into the material of the reinforcement element 107.8, avoiding high stress concentrations in the prosthetic heart valve 100.
  • the intent of this design is to limit the leaflet travel during the opening phase by pinching the commissure area to prevent the leaflets 102 from hitting the stent 10.
  • this assembly method displaces the valve commissures inward radially from the stent post to further limit the leaflets from hitting the stent.
  • Fig. 21 illustrates an alternative way of attachment of the prosthetic heart valve 100 according to Figs. 3 and 4 of the present disclosure.
  • the sleeves 111 of adjacent separate pieces 120 are formed to enclose an inner cushion 107.2.
  • the leaflets 102 are displaced from the commissure attachment region l ib to limit the leaflets 102 form hitting the stent. Furthermore, the sutures 101.1 extending through the sleeves 111 and the inner cushion 107.2 are more hidden and the edges of the sleeves 111 are tucked under the inner cushion 107.2. Therefore, in this embodiment, the wear of the prosthetic heart valve 100, is significantly reduced as the leaflets 102 of the prosthetic heart valve are not in direct contact with knots of the sutures 101.1 or the edges of the sleeves 111 respectively.
  • reinforcement elements 107.1 - 107.8 in order to reduce wear.
  • any dependent claim which follows should be taken as alternatively written in a multiple dependent form from all prior claims which possess all antecedents referenced in such dependent claim if such multiple dependent format is an accepted format within the jurisdiction (e.g . each claim depending directly from claim 1 should be alternatively taken as depending from all previous claims).
  • each claim depending directly from claim 1 should be alternatively taken as depending from all previous claims.
  • the following dependent claims should each be also taken as alternatively written in each singly dependent claim format which creates a dependency from a prior antecedent-possessing claim other than the specific claim listed in such dependent claim below.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
PCT/EP2011/058506 2010-05-25 2011-05-24 Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent Ceased WO2011147849A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2011257298A AU2011257298B2 (en) 2010-05-25 2011-05-24 Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
JP2013511662A JP2013526388A (ja) 2010-05-25 2011-05-24 人工心臓弁、及び人工心臓弁とステントを備える経カテーテル搬送体内プロテーゼ
CN201180036365.4A CN103002833B (zh) 2010-05-25 2011-05-24 人工心脏瓣及包括人工心脏瓣和支架的经导管输送的内假体
BR112012029896A BR112012029896A2 (pt) 2010-05-25 2011-05-24 válcula cardíaca protética para endoprótese e endoprótese
EP11721068.2A EP2575681B1 (en) 2010-05-25 2011-05-24 Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
CA2799459A CA2799459A1 (en) 2010-05-25 2011-05-24 Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
IL222936A IL222936A0 (en) 2010-05-25 2012-11-08 Prosthetic heart valve for an endoprosthesis and an endoprosthesis comprising such a valve

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US34803610P 2010-05-25 2010-05-25
EP10163831.0 2010-05-25
EP10163831 2010-05-25
US61/348,036 2010-05-25

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US (4) US9744031B2 (enExample)
EP (1) EP2575681B1 (enExample)
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CN (1) CN103002833B (enExample)
AU (1) AU2011257298B2 (enExample)
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