EP0850607A1 - Valve prosthesis for implantation in body channels - Google Patents

Valve prosthesis for implantation in body channels Download PDF

Info

Publication number
EP0850607A1
EP0850607A1 EP19960402929 EP96402929A EP0850607A1 EP 0850607 A1 EP0850607 A1 EP 0850607A1 EP 19960402929 EP19960402929 EP 19960402929 EP 96402929 A EP96402929 A EP 96402929A EP 0850607 A1 EP0850607 A1 EP 0850607A1
Authority
EP
Grant status
Application
Patent type
Prior art keywords
frame
valvular structure
valvular
structure
characterized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19960402929
Other languages
German (de)
French (fr)
Inventor
Alain Cribier
Brice Letac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cordis Corp
Original Assignee
Cordis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2409Support rings therefor, e.g. for connecting valves to tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415Manufacturing methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2427Devices for manipulating or deploying heart valves during implantation
    • A61F2/243Deployment by mechanical expansion
    • A61F2/2433Deployment by mechanical expansion using balloon catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2475Venous valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028Shapes in the form of latin or greek characters
    • A61F2230/0054V-shaped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0069Three-dimensional shapes cylindrical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/006Additional features; Implant or prostheses properties not otherwise provided for modular
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/90Stent for heart valve
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902Method of implanting
    • Y10S623/904Heart

Abstract

The present invention is aimed to provide a valve prothesis (IV) especially used in case of aortic stenosis, which structure is capable of resisting the powerful recoil force and to stand the forceful balloon inflation performed to deploy the valve and to embed it in the aortic annulus.
A valve prosthesis (13) for implantation in a body channel according to the invention comprise a collapsible valvular structure (14) and an expandable frame (10, 10') on which said valvular structure (14) is mounted. The valvular structure (14) is composed of a valvular tissue compatible with the human body and blood, the valvular tissue being sufficiently supple and resistant to allow said valvular structure (14) to be deformed from a closed state to an opened state. Said valvular tissue forms a continuous surface and is provided with guiding means (17) formed or incorporated within, said guiding means creating stiffened zones which induce said valvular structure (14) to follow a patterned movement in its expantion to its opened state and in its turning back to its closed state. The valvular structure can be extended to an internal cover (19) which is fastened to the lower end (15) of the valvular structure to prevent from regurgitation.

Description

The present invention relates to a valve prosthesis for implantation in body channels, more particularly but not only, to cardiac valve prosthesis to be implanted by a transcutaneous catheterization technique.

It can be also applied to other body channels provided with native valves, such as veins or in organs (liver, intestine, urethra,...).

The present invention also relates to a method for implanting a valve prosthesis, such as the valve according to the present invention.

Implantable valves, which will be indifferently designated hereafter as "IV", "valve prosthesis" or "prosthetic valve", allows to repair a valvular defect by a little invasive technique in place of the usual surgical valve implantation which, in the case of valvular heart diseases, requires thoracotomy and extracorporeal circulation. A particular indication for the IV concerns the patients who cannot be operated on because of associated disease or because of their very old age or also patients who could be operated on but only at a very high risk.

Although the IV of the present invention and the process for implanting said IV can be used in various heart valve diseases, the following description will first concern the aortic orifice in aortic stenosis, more particularly in its degenerative form in the elderly patients.

Aortic stenosis is a disease of the aortic valve which is the way out of the left ventricle of the heart. The aortic valvular orifice is normally capable of opening during systole up to 4 to 6 cm2, therefore allowing free ejection of the ventricular blood volume into the aorta. This aortic valvular orifice can become tightly stenosed, and therefore the blood cannot anymore be freely ejected from the left ventricle. In fact, only a reduced amount of blood can be ejected by the left ventricle which has to markedly increase the intra-cavitary pressure to force the stenosed aortic orifice. In such aortic diseases, the patients can have syncope, chest pain, and mainly difficulty in breathing. The evolution of such a disease is disastrous when symptoms of cardiac failure appear since 50 % of the patients die in the year following the first symptoms of the disease.

The only commonly available treatment is the replacement of the stenosed aortic valve by a prosthetic valve by surgery this treatment moreover providing excellent results. If surgery is impossible to perform i.e. if the patient is deemed inoperable or operable only at a too high surgical risk, an alternative possibility is to dilate the valve with a balloon catheter to enlarge the aortic orifice. Unfortunately, a good result is obtained only in about half of the cases and there is a high restenosis rate, i.e., about 80% after one year.

Now, aortic stenosis is a very common disease in people above seventy years old and is more and more frequent as a subject get older. Moreover, the present tendency of the general evolution of the population is to become older and older. Also, It can be evaluated as a crude estimation that about 30 to 50% of the subjects who are older than 80 years and have a tight aortic stenosis, either cannot be operated on for aortic valve replacement with a reasonable surgical risk or even cannot be considered at all for surgery.

It can be estimated that, about 30 to 40 persons out of a million per year could benefit from an implantable aortic valve positioned by a catheterization technique. Until now, the implantation of a valve prosthesis for the treatment of aortic stenosis is considered unrealistic to perform since it is deemed difficult to superpose another valve such an implantable valve on the distorted stenosed native valve without excising this latter.

From 1985, the technique of aortic valvuloplasty with a balloon catheter has been introduced for the treatment of subjects in whom surgery cannot be performed at all or which could be performed only with a prohibitive surgical risk. Despite the considerable deformation of the stenosed aortic valve, commonly with marked calcification, it is most often possible to enlarge significantly the aortic orifice by balloon inflation, a procedure which is low risk.

However, this technique has been abandoned by most catheterizers because of the very high restenosis rate which occurs in about 80% of the patients within 10 to 12 months. Indeed, immediately after deflation of the balloon, a strong recoil phenomenon most often produces a lost of half or even two third of the opening area obtained by the inflated balloon. For instance, inflation of a 20 mm diameter balloon in a stenosed aortic orifice of 0.5 cm2 area gives, when forcefully and fully inflated, an opening area equal to the cross sectionnal area of the maximally inflated balloon, i.e. about 3 cm2. However, measurements performed few minutes after deflation and pull back of the balloon find only an area around 1 cm2 to 1.2 cm2. This is due to the considerable recoil of the fibrous tissue of the diseased valve. This drawback in this procedure has also been clearly shown on fresh post mortem specimen.

However, it is important to note that whereas the natural normal aortic valve is capable to open with an orifice of about 5 to 6 cm2 and to accommodate a blood flow of more that 15 l/min. during heavy exercise for instance, an opening area of about 1.5 to 2 cm2 is enough to accept without significant pressure gradient a 6 to 8 l/min. blood flow. Such a flow corresponds to the cardiac output of the elderly subject with limited physical activity.

Therefore, an IV would not have to produce a large opening of the aortic orifice since an opening about 2 cm2 would be enough in most subjects, in particular in these elderly subjects whose cardiac output probably does not reach more than 6 to 8 l/min. during a normal physical activity. For instance, the surgically implanted mechanical valves have an opening area which is far from the natural valve opening that ranges from 2 to 2.5 cm2, mainly because of the room taken by the large circular structure supporting the valvular part of the device.

The prior art describes examples of cardiac valves prosthesis that are aimed at being implanted without surgical intervention by way of catheterization. For instance, US patent n° 5,411,552 describes a collapsible valve able to be introduced in the body in its compressed presentation and expanded in the right position by balloon inflation.

Such valves, with semi-lunar leaflets design, tend to imitate the natural valve. However, this type of design is inherently fragile, and such structures are not strong enough to be used in case of aortic stenosis because of the strong recoil that will distort this too weak structure and because they would not be able to resist the balloon inflation performed to position the implantable valve. Furthermore, this valvular structure is attached to a metallic frame of thin wires that will not be able to be tightly secured against the valve annulus. The metallic frame of this implantable valve which is made of thin wires like in the stents which are implanted in vessels after balloon dilatation. Such a light stent structure is too weak to allow the forceful embedment of the implantable valve into the aortic annulus. Moreover, there is a high risk of massive regurgitation (during the diastolic phase) through the spaces between the frame wires which is another prohibitive risk that would make this implantable valve impossible to use in clinical practice.

Furthermore, an important point in view of the development of the IV is that it is possible to maximally inflate a balloon placed inside the compressed implantable valve to expand it and insert it in the stenosed aortic valve up to about 20 to 23 mm in diameter. At the time of maximum balloon inflation, the balloon is absolutely stiff and cylindrical without any waist. At that moment, the implantable valve is squeezed and crushed between the strong aortic annulus and the rigid balloon with the risk of causing irreversible damage to the valvular structure of the implantable valve.

The invention is aimed to overcome these drawbacks and to implant an IV which will remain reliable for years.

A particular aim of the present invention is to provide an IV, especially aimed at being used in case of aortic stenosis, which structure is capable of resisting the powerful recoil force and to stand the forceful balloon inflation performed to deploy the IV and to embed it in the aortic annulus.

Another aim of the present invention is to provide an efficient prosthesis valve which can be implanted by a catheterization technique in particular in a stenosed aortic orifice, taking advantage of the strong structure made of the distorted stenosed valve and of the large opening area produced by a preliminary balloon inflation, performed as an initial step of the procedure.

A further aim of the present invention is to provide an implantable valve which would not produce any risk of fluid regurgitation.

A further aim of the present invention is to provide a valve prosthesis implantation technique using a two-balloons catheter and a two-frame device.

These aims are achieved according to the present invention which provides a valve prosthesis of the type mentioned in the introductory part and wherein said valve prosthesis comprises a collapsible continuous structure with guiding means providing stiffness and a frame to which said structure is fastened, said frame being enough strong to resist to the recoil phenomenon of the fibrous tissue of the diseased valve.

A strong embedment enables to maintain the implantable valve in the right position without any risk of further displacement, which would be a catastrophic event.

More precisely, this valvular structure comprises a valvular tissue compatible with the human body and blood, which is supple and resistant to allow said valvular structure to be deformed from a closed state to an opened state to allow a body fluid, more particularly the blood exerting pressure on said valvular structure, to flow. This valvular tissue forms a continuous surface and is provided with guiding means formed or incorporated within, creating stiffened zones which induce the valvular structure to follow a patterned movement from its opened position to its closed state and vice-versa, providing therefore a structure sufficiently rigid to prevent eversion, in particular into the left ventricle and thus preventing any regurgitation of blood into the left ventricle in case of aortic implantation.

Moreover, the guided structure of the IV of the invention allows the tissue of this structure to open and close with the same patterned movement while occupying as less as possible space in the closed state of the valve. Therefore, owing to these guiding means the valvular structure stands the unceasing movements under the blood pressure changes during the heart beats.

Preferably, the valvular structure has a substantially truncated hyperboloïdal shape in its expanded position, with a larger basis and a growing closer neck, ending to a smaller extremity forming the upper part of the valvular structure. The valvular structure has thus a curvature of its surface concave towards the aortic wall. Such a shape produces a strong and efficient structure in view of a systolo-diastolic movement of the valvular tissue. Such a valvular structure with its simple and regular shape also lowers the risk of being damaged by a forceful balloon inflation at time of IV deployment.

A trunco-hyperboloïdal shape with a small diameter at the upper extremity facilitates the closure of the valve at the beginning of diastole in initiating the starting of the reverse movement of the valvular tissue towards its base. Another advantage of this truncated hyperboloïdal shape is that the upper extremity of the valvular structure, because of its smaller diameter, remains at a distance of the coronary ostia during systole as well as during diastole, thus offering an additional security to make sure not to impede at all the passage of blood from aorta to the coronary ostia.

As an advantageous embodiment of the invention, the guiding means of the valvular structure are inclined strips from the base to the upper extremity of the valvular structure with regard to the central axis of the valvular structure. Then, this inclination initiates and impart a general helicoidal movement of the valvular structure around said central axis at time of closure or opening of said structure, such a movement enabling to help initiating and finalizing the closure of the valvular structure In particular, this movement improves the collapse of the valvular structure towards its base at time of diastole, during the reversal of flow at the very beginning of diastole. During diastole, the valvular structure thus falls down, folding on itself, up to collapse on its base, and therefore closing the aortic orifice. The strips can be pleats, strenghthening struts or thickened zones.

In other embodiments, said guiding means are rectilinear strips from the base to the upper extremity of the valvular structure. In this case, the guiding means can comprise pleats, struts or thickened zones. In a particular embodiment, the stiffened zones then created can be advantageously two main portions, trapezoidal in shape, formed symmetrically one to each other with regard to the central axis of the valvular structure, and two less rigid portions separating said two main portions to lead to a tight closeness in shape of a closed slot at time of closure of the upper extremities of the main portions of the valvular structure. The thickened zones can be extended up to form the stiffened zones.

More particularly, each of said main slightly rigid portions occupies approximately one third of the circumference of the valvular structure when this latter is in its open position. The slightly rigid portions allow to maintain the valvular structure closed during diastole by firmly applying themselves each on the other. The closure of the valvular structure at time of diastole thus does not have any tendency to collapse too much towards the aortic annulus.

Preferably, the guiding means are a number of pleats formed within the tissue by folding this latter, or formed by recesses or grooves made in the tissue. The shape of the pleats is adapted to achieve a global shape of the desired type for said position.

Alternatively, the guiding means are made of strengthening struts, preferably at least three, incorporated in the tissue in combination or not with said pleats.

The guiding means and, in particular, the strengthening struts help preventing the valvular tissue to collapse back too much and to reverse inside the left ventricle through the base of the frame, preventing the risk of blood regurgitation.

In a preferred prosthetic valve of the invention, said valvular tissue is made of synthetic biocompatible material as Teflon® or Dacron®, or made of biological material as pericardium, porcine leaflets and the like. These materials are commonly used in cardiac surgery and are quite resistant, particularly to the folding movements as the inceasing systolo-diastolic movements of the valvular tissue and particularly at the junction with the frame of the implantable valve.

The valvular structure is fastened along a substantial portion of an expandable frame, by sewing, by molding or by gluing to exhibit a tightness sufficiently hermetical to prevent any regurgitation of said body fluid between the frame and the valvular structure.

Preferably, an internal cover is coupled or is integral to the valvular structure and placed between said valvular structure and the internal wall of the frame to prevent any passage of the body fluid through said frame. Therefore, there is no regurgitation of blood as it could be if there were any space between the valvular structure fastened on the frame and the zone of application of the frame on the aortic annulus. The internal cover makes a sort of "sleeve" at least below the fastening of the valvular structure covering the internal surface of the frame and thus preventing any regurgitation of blood through the frame.

In the present invention, the frame is a substantially cylindrical structure capable of maintaining said body channel open in its expanded state and supporting said collapsible valvular structure.

In a preferred embodiment of the invention, the frame is made in a material which is distinguishable from biological tissue to be easily visible by non invasive imaging techniques.

Preferably, said frame is a stainless metal structure or a foldable plastic material, made of intercrossing preferably with rounded and smooth linear bars. This frame is strong enough to resist to the recoil phenomenon of the fibrous tissue of the diseased valve. The size of the bars and their number are determined to give both the maximal rigidity when said frame is expanded and the smallest volume when the frame is compressed.

More preferably, the frame has projecting curved extremities and presents a concave shape. This is aimed at reinforcing the embedding and the locking of the implantable valve in the distorted aortic orifice.

In a preferred embodiment of the present invention, the IV is made in two parts, a first reinforced frame coupled with a second frame which is made of thinner bars than said first frame and which is embedded inside this latter. This second frame to which the valvular structure is fastened as described above, is preferably less bulky than the first frame to occupy less room as possible and to be easily expanded with a low pressure balloon inflation.

The present invention also relates to a double balloon catheter to separately position the first frame in the dilated stenosed aortic valve and place the second frame that comprise the valvular structure. This catheter comprises two balloons fixed on a catheter shaft and separated by few centimeters.

The first balloon is of the type sufficiently strong to avoid bursting even at a very high pressure inflation and is aimed at carrying, in its deflated state, a strong frame aimed at scaffolding the previously dilated stenosed aortic valve. The second balloon is aimed at carrying the second frame with the valvular structure.

An advantage of this double balloon catheter is that each set of balloon has an external diameter which is smaller than known balloons since each element to be expanded is smaller.

Moreover, such a double balloon catheter allows to enlarge the choice for making an efficient valvular structure enabling to overcome two contradictory conditions:

  • 1) having a soft and mobile valvular structure capable to of opening and closing freely in the blood stream, without risk of being damaged by the balloon inflation;
  • 2) needing a very strong structure able to resist the recoil force of the stenosed valve and capable resisting without any damage a strong pressure inflation of the expanding balloon.

Furthermore, the shaft of said double balloon catheter comprises two lumens for successive and separate inflation of each balloon. Of note, an additional lumen capable of allowing a fast inflation takes additional room in the shaft.

The invention also relates to a method using a two-balloon catheter with a first frame and second frame to which a valve prosthesis of the type previously described is fastened.

The invention will now be explained and other advantages and features will appear with reference to the accompanying schematical drawings wherein :

  • Figures 1a, 1b and 1c show, in section views, respectively the normal aortic valve in systole, in diastole and a stenosed aortic valve;
  • Figures 2a and 2b show two examples of a metallic frame which could be combined to a valvular structure according to the present invention;
  • Figures 3a and 3b show a frame according to the invention in its expanded presentation with an opening out of the extremities respectively with a cylindrical and a concave shape;
  • Figures 4a and b show an IV of the invention respectively in its compressed presentation and in its expanded presentation in open position as in systole;
  • Figures 5a and 5b show respectively an IV of the invention in its closed presentation and a sectional view according to the central axis of such a valvular structure closed as in diastole;
  • Figures 6a to 6c, a sectional view according to the central axis of an IV according to the present invention and showing the internal cover of the valvular structure overlapping partially or not the frame bars;
  • Figure 7 shows the frontal zig-zag fastening line of the valvular tissue on the frame;
  • Figures 8a and 8b show, respectively, a perspective view of a valvular structure and an internal cover made all of a piece and a perspective view of the corresponding frame into which they will be inserted and fastened;
  • Figures 9a and 9b show inclined strengthening struts of an example of a valvular structure according to the invention, respectively in the open position and in the closed position:
  • Figures 10a and 10b show an example of a valvular structure comprising pleats, respectively in the open and in the closed position;
  • Figures 11a and 11b show a valvular structure comprising two trapezoïdal slightly rigid portions, respectively in the opened and in the closed position;
  • Figures 12a and 12b show, respectively, a perspective and a cross sectional views of an implantable valve in its compressed presentation squeezed on a balloon catheter;
  • Figures 13a to 13l show views of the successive procedure steps for the IV implantation in a stenosed aortic orifice;
  • Figure 14 show an implantable valve made in two parts in its compressed presentation squeezed on a two-balloons catheter with a reinforced frame on a first balloon and with the implantable valve on the second balloon;
  • Figures 15a to 15f show the successive steps of the implantation of the implantation valve in two parts with a two-balloons catheter;

In the diastole and systole illustrations of section views of figures 1a and 1b, the arrows A indicate the general direction of the blood movements. The semi-lunar leaflets 1 and 2 of a native aortic valve (with only two out of three shown here) are thin, supple and move easily from the completely opened position (systole) to the closed position (diastole). The leaflets are originate from an aortic annulus 2a.

The leaflets 1' and 2' of a stenosed valve as illustrated in figure 1c, are thickened, distorted, calcified and more or less fused, leaving only a small hole or a narrow slit 3, which makes the ejection of blood from the left ventricle cavity 4 into the aorta 5 difficult and limited. Figures 1a to 1c show also the coronary artery ostium 6a and 6b and figure 1a shows in particular the mitral valve 7 of the left ventricle cavity 4.

An implantable valve according to the invention essentially comprises a supple valvular structure supported by a strong frame. The positioning of the implantable valve is an important point since the expanded frame has to be positioned exactly at the level of the native valvular leaflets 1, 2 of the native valve, the structures of which are pushed aside by the inflated balloon.

Ideally, the implantable valve is positioned with the fastening line of the valvular structure on the frame exactly on the remains of the crushed stenosed valve to prevent any regurgitation of blood. In practice, it is difficult to position the implantable valve within less than 2 or 3 mm. However, any risk of regurgitation of blood is eliminated with the presence of an internal cover, as it will be described below.

The upper limit of the frame should be placed below the opening of the coronary arteries, i.e. the coronary ostia 6, or at their level so that the frame does not impede free blood flow in the coronary arteries. This point is a delicate part of an IV positioning since the distance between the superior limit of the leaflets of the natural valve and the coronary ostia 6 is only about 5 to 6 mm. However, the ostia are located in the Valsalva sinus 8 which constitutes a hollow that put them a little out of the way. This helps preventing from impeding the coronary blood flow by the IV.

At time of implantation, the operator evaluates the exact positioning of the coronary ostia in looking at the image produced by a sus-valvular angiogram with contrast injection performed before the implantation procedure. This image will be fixed in the same projection on a satellite TV screen and will allow to evaluate the level of the origin of the right and left coronary arteries. Possibly, in case the ostia are not clearly seen by sus-valvular angiography, a thin guide wire, as those used in coronary angioplasty, is positioned in each of the coronary artery to serve as a landmark of the coronary ostia.

The lower part of the frame of the IV preferably extends by 2 or 3 mm inside the left ventricle 4, below the aortic annulus 2a. However, this part of the frame should not reach the insertion of the septal leaflet of the mitral valve 7, so that it could not interfere with its movements, particularly during diastole.

Figures 2a and 2b show respectively an example of a cylindrical frame 10 comprising intercrossing linear bars 11, with two intersections I by bar 11, the bars 11 being soldered or provided from a folded wire to constitute the frame, with for instance a 20 mm, 15 mm or 12 mm height, and an example with only one intersection of bars 11. Preferably, such a frame is expandable from a size of about 4 to 5 millimeters to a size of about 20 to 25 mm in diameter, or even to about 30-35 mm (or more) in particular cases, for instance for the mitral valve. Moreover, said frame, in its fully expanded state, has a height of approximately between 10 and 15 mm and in its fully compressed frame, a height of approximately 20 mm. The number and the size of the bars are adapted to be sufficiently strong and rigid when the frame is fully opened in the aortic orifice to resist to the strong recoil force exerted by the distorted stenosed aortic orifice after deflation of the balloon used in a catheterization technique which has been previously maximally inflated to enlarge the stenosed valve orifice

The frame may have several configurations according to the number of bars 11 and intersections. This number as well as the size and the strength of the bars 11 are calculated taking into account all the requirements described, i.e. a small size in its compressed form, its capacity to be enlarged up to at least 20 mm in diameter and being strong when positioned in the aortic orifice both to be able to be forcefully embedded in the remains of the deceased aortic valve and to resist the recoil force of the aortic annulus. The diameter of the bars is choosen, for instance, in the range 0,1-0,6 mm.

A frame particularly advantageous presents, when deployed in its expanded state, an opening out 12 at both extremities as shown in figures 3a and 3b, the frame having a linear profile (figure 3a) or a concave shape profile (figure 3b). This is aimed at reinforcing the embedding of the IV in the aortic orifice. However, the free extremities of the openings 12 are rounded and very smooth to avoid any traumatism of the aorta or of the myocardium.

The structure of a preferred frame used in the present invention both maintains the aortic orifice fully open once dilated and produces a support for the valvular structure. The frame is also foldable. When folded by compression, the diameter of said frame is about 4 to 5 millimeters, in view of its transcutaneous introduction in the femoral artery through an arterial sheath of 14 to 16 F (F is the symbol of French, a unit usually used in cardiology field) i.e. about 4,5 to 5,1 mm. Also, as described below, when positioned in the aortic orifice, the frame is able to expand under the force of an inflated balloon up to a size of 20 to 23 mm in diameter.

The frame is preferably a metallic frame, preferably made of steel. It constitutes a frame with a grate type design able both to support the valvular structure and to behave as a strong scaffold for the opened stenosed aortic orifice.

When the frame is fully expanded; its intercrossing bars push against the remains of the native stenosed valve that has been crushed aside against the aortic annulus by the inflated balloon. This produces a penetration and an embedding of the bars within the remains of the stenosed valve, in particular owing to a concave profile of the frame provided with an opening out, as illustrated in figure 3b. This bite of the frame on the aortic annulus, or more precisely on the remains of the crushed distorted aortic valve, will be determinant for the strong fixation of the IV in the right position, without any risk of displacement.

Moreover, the fact that the valve leaflets in degenerative aortic stenosis are grossly distorted and calcified, sometimes leaving only a small hole or a small slit the middle of the orifice, has to be considered an advantage for the implantation of the valve and for its stable positioning without risk of later mobilization. The fibrous and calcified structure of the distorted valve gives a strong basis to the frame of the IV and the powerful recoil phenomenon that results from elasticity of the tissues contribute to the fixation of the metallic frame.

The height of the fully expanded frame of the illustrated frames 10 is preferably between 10 and 15 mm. Indeed, since the passage from the compressed state to the expanded state results in a shortening of the metallic structure, the structure in its compressed form is a little longer, i.e. preferably about 20 mm length. This does not constitute a drawback for its transcutaneous introduction and its positioning in the aortic orifice.

As mentioned above, the frame is strong enough to be able to oppose the powerful recoil force of the distended valve and of the aortic annulus 2a. Preferably it does not possess any flexible properties. When the frame has reached its maximal expanded shape under the push of a forcefully inflated balloon, it remains substantially without any decrease in size and without any change of shape. The size of the bars that are the basic elements of the frame of the frame is calculated in such a way to provide a substantial rigidity when the frame is fully expanded. The size of the bars and their number are calculated to give both the maximal rigidity when expanded and the smallest volume when the metallic frame is its compressed presentation.

At time of making the IV, the frame is expanded by dilatation to its broadest dimension, i.e. between 20 mm and 25 mm in diameter, so as to be able to fasten the valvular structure on the inside side of its surface. This fastening is performed using the techniques in current use for the making of products such as other prosthetic heart valves or multipolars catheters etc. Afterwards, it is compressed in its minimal size, i.e. 4 or 5 mm, in diameter in view of its introduction in the femoral artery. At time of the IV positioning, the frame is expanded again by balloon inflation to its maximal size in the aortic orifice.

If the frame is built in its expanded presentation, it will be compressed, after fastening of the valvular structure, by exerting a circular force on its periphery on its total height until obtaining the smallest compressed presentation If the frame is built in its compressed presentation, it will be first dilated for instance by inflation of a balloon and then compressed again as said above.

To help localizing the IV, the frame being the only visible component of the valve, the shaft of the balloon catheter on which will be mounted the IV before introduction in the body (see below) possesses preferentially metallic reference marks easily seen on fluoroscopy. One mark will be at level of the upper border of the frame and the other at the level of the lower border. The IV, when mounted on the catheter shaft and crimpled on it, is exactly positioned taking into account these reference marks on the shaft.

Accordingly, the frame is visible at fluoroscopy when introduced in the patient's body. When the frame is positioned at the level of the aortic annulus, the upper border of the frame is placed below the coronary ostia. Furthermore, the implanting process during which the balloon inflation completely obstruct the aortic orifice, as seen below, is performed within a very short time, around 10 to 15 seconds. This explains also why the frame is clearly and easily seen, without spending time to localize it. More particularly, its upper and lower borders are clearly delineated.

Figures 4a and 4b show an example of a preferred IV 13 of the present invention, respectively in its compressed presentation, in view of its introduction and positioning in the aortic orifice, and in its expanded and opened (systole) presentation. Figures 5a and 5b show the expanded presentation of this example closed in diastole, respectively in perspective and in crossed section view along the central axis X'X of the valve prosthesis.

The valvular structure 14 is compressed inside the frame 10 when this one is in its compressed presentation (figure 4a), i.e. it gets into a 4 to 5 mm diameter space. On the other hand, the valvular structure expands (figure 4b) and follows the frame expansion produced by the balloon inflation. It will have to be able to reach the size of the inside of the fully deployed frame.

The illustrated IV 13 is made of a combination of two main parts:

  • 1) the expansible but substantially rigid structure made of the frame 10, a metallic frame in the example;
  • 2) a soft and mobile tissue constituting the valvular structure 14 exhibiting a continuous surface truncated between a basis 15 and an upper extremity 16; the tissue is fastened to the bars 11 of the frame at its basis 16 and is able to open in systole and to close in diastole at its extremity 16, as the blood flows in a pulsate way from the left ventricle towards the aorta.

The tissue has rectilinear struts 17 incorporated in it in plans including the central axis X'X, in order to strengthen it in particular in its closed state with a minimal occupation of the space, and to induce a patterned movement between its opened and closed state. Other examples of strengthening struts are described below. They are formed from thicker zones of the tissue or from strips of stiffening material incorporated in the tissue.

These strengthening struts help preventing the valvular tissue to collapse back too much and to reverse inside the left ventricle through the base of the frame. These reinforcements of the valvular tissue help maintaining the folded tissue above the level of the orifice during diastole, preventing too much folding back and risk of inversion of the valvular structure inside the left ventricle. By also preventing too much folding it can also be expected a decrease of the risk of thrombi formation by reducing the number of folds.

The truncated shape forming a continuous surface enables to obtain a strong structure and more efficient for the systolo-diastolic movements of the valvular tissue during heart beats. The truncoïdal shape facilitates the closure of the valve structure at the beginning of diastole in facilitating the start of the reverse movement of the valvular tissue towards its base at time of diastole, at time of reversal of flow at the very beginning of diastole. During diastole, the valvular structure 14 thus falls down, folding on itself, up to collapse on its base, and therefore closing the aortic orifice. In fact, the valvular structure has preferably, as illustrated, an hyperboloid shape, with a curvature of its surface concave towards the aortic wall that will contribute initiating closing it.

Moreover, the basis of the truncated hyperboloïd is fixed on the lower part of a frame and the smallest extremity of the truncated hyperboloïd is free in the blood stream, during the respecting closing and opening phasis.

An important advantage of this hyperboloïdal shape is that the upper extremity 16 of the valvular structure 14 can remain at a distance of the coronary ostia during systole as well as during diastole, because of its smaller diameter, thus offering an additional security to make sure not to impede at all the passage of blood from aorta to the coronary ostia.

The basis 15 of the truncated tissue is attached on the frame of the frame 10 along a line of coupling 18 disposed between the inferior fourth and the third fourth of the frame in the example. The upper extremity 16, with the smaller diameter, overpasses the upper part of the frame by few millimeters, 6 to 8 mm for instance. This gives the valvular structure a total height of about 12 to 15 mm.

The upper extremity 16 of the truncated tissue, i.e. the smaller diameter of the hyperboloïdal structure 14, has about 17 to 18 mm in diameter (producing a 2.3 to 2.5 cm2 area opening) for a 20 mm diameter of the base of the truncated tissue, or 19 to 20 mm in diameter (producing a 2.8 or a 3 cm2 area opening) for a 23 mm diameter base. An opening area around 2 cm2 or slightly above gives satisfactory results, particularly in elderly patients who would not reasonably need to exert high cardiac output possibilities.

For instance, in the present example, the line of fastening of the basis of the truncated tissue on the frame will have to expand from a 12,5 mm perimeter (for a 4 mm external diameter of the compressed IV) to a 63 mm perimeter ( for a 20 mm external diameter of the expanded IV ), or to a 72 mm perimeter (for a 23 mm external diameter, in case a 23 mm balloon is used).

Another advantage of this truncated continuous shape is that it is stronger with less risk of being destroyed or distorted by the forceful balloon inflation at time of IV deployment. Also, if the truncated hyperboloïdal shape is marked, for instance with a 16 or 17 mm diameter of the upper extremity as compared to a 20 mm diameter of the basis (or 18 to 20 mm for 23 mm), the smaller upper part is compliant during balloon inflation in order to enable the balloon to expand cylindrically to its maximal 20 mm diameter (or 23 mm). This is made possible by using a material with some elastic or compliant properties.

The valvular structure of the invention, as shown in the illustrated example, includes advantageously a third part, i.e. the internal cover 19 to be fixed on the internal wall of the frame 10. This internal cover prevents any passage of blood through the spaces between bars 11 of the frame in case the implantable valve would be positioned with the fastening line of the valvular structure on the frame not exactly on the remains of the dilated aortic valve, i.e. either above or below. It would also strengthen the fastening of the valvular structure 14 to the frame 10.

On the different sectional views of different examples of IV according to the invention, as illustrated at figures 6a to 6c, the internal cover 19 covers the totality of the internal side of the frame 10 (figure 6a), only the lower part of the frame 10 (figure 6b), or it can additionally cover partially 3 to 5 mm as shown in figure 6c, the upper part defined above the coupling line 18 of the valvular structure.

For instance, such an extension of the internal cover 19 above the fastening line 18 of the valvular structure will give another security to avoid any risk of regurgitation through the spaces between the bars 11 in case the IV would be positioned too low with regard to the border of the native aortic valve.

The internal cover can also be mold with the valvular structure or cast to it which therefore constitute an integral structure. The valvular structure and the internal cover are therefore strongly locked together with minimum risk of distachement of the valvular structure which is unceasingly in motion during systole and diastole. In that case, only the internal cover has to be fastened on the internal surface of the frame which renders the making of the IV easier and make the complete device stronger and more resistant. In particular, the junction of the mobile part of the valvular structure and the fixed part being mold all of a piece is stronger and capable to face the inceasing movements during the systolo-diastolic displacements without any risk of distachement.

The presence of the internal cover makes an additional layer of plastic material that takes room inside the frame and increases the final size of the IV. Therefore, in the case in which the internal cover is limited to the inferior part of the frame (that is below the fastening line of the valvular structure), it does riot take any additional space inside the frame. Here also, it is more convenient and safer to make the valvular structure and this limited internal cover all of a piece.

In other respects, to prevent any regurgitation of blood from the aorta towards the left ventricle during diastole the basis of the valvular structure is preferably positioned exactly at the level of the aortic annulus against the remains of the distorted stenosed valve pushed apart by the inflated balloon. Therefore, there is no possibility of blood passage through the spaces between the metallic frame bars 11 below the attachment of the valvular structure.

However, to avoid any risk of leaks, the part of the frame below the fastening of the valvular structure (about 3 to 5 mm) is preferably covered by an internal cover which is preferably made with the same tissue than the valvular structure. Thus, there would be no regurgitation of blood as it could do if there were any space between the valvular structure fastened on the metallic frame and the line of application of the frame on the aortic annulus. The internal cover makes a sort of "sleeve" below the fastening of the valvular structure on the internal surface of the frame, covering the spaces between the frame bars of the frame at this level, thus preventing any regurgitation of blood through these spaces.

The internal cover can also have another function, i.e. it can be used to fasten the valvular structure inside the frame, as described below.

The coupling process of the valvular structure on the frame is of importance since it has to be very strong without any risk of distachement of the valvular structure from the frame during millions of heart beats with pulsatile blood flow alternatively opening and closing the valvular structure.

The valvular structure of the invention is foldable in a very small size inside the frame in the compressed presentation of the valve and is expandable up to 20 to 23 mm diameter. Also, the valvular structure can resist the strong force exerted by the maximally inflated balloon that will powerfully squeeze it against the bars of the frame or against the internal cover, this one being squeezed directly against the bars of the frame. The junction zone is also particularly submitted to the very strong pressure exerted by the inflated balloon. Furthermore, this junction zone must not tear or break of during expansion of the balloon. At this time, each part of the junction zone is squeezed against the bars but nonetheless follows the expansion of the frame.

As shown on figure 7, the junction zone is for example a fastening line 20 which follow the design of a "zig-zag" line drawn by the intercrossing bars 11 of the frame on the internal cover 19.

The fastening of the valvular structure to the frame can be made by sewing the internal cover on the bars. To prevent any leak of blood the stitches are preferably numerous and very close to each other, either separated stitches or made as a continuous suture line. Also, the stitches are made directly around the bars 11. Furthermore, since the valvular structure is expanded together with the metallic frame, the stitches, if made as a continuous suture line, are also able to expand at the same time.

The fastening process can also be made by molding the base of the valvular structure on the frame. At this level, the bars 11 are imbedded in the coupling line of the valvular structure 14. This molding also concerns the internal cover 19, when it goes below the coupling line 14 on the frame over few millimeters for example 2 to 4 mm. As mentioned above, this is intended in order to prevent any regurgitation of blood just below the lower part of the valvular structure 14 in case the frame 10 would not be exactly positioned on the aortic annulus but at few millimeters.

The fastening process can further be made by gluing the valvular structure on the bars with sufficiently powerful biocompatible glues. The same remark can be made concerning the internal cover of the frame below the coupling line of the valvular structure.

Also, this allow the coupling line to follow the frame changes from compressed presentation to its expanded one.

The valvular structure can also be fastened on the internal cover previously fixed on the total length of the internal surface of the metallic frame. The internal cover constitutes therefore a surface on which any type of the valvular structure be more easily sewed, molded or glued. Because it is a structure with a large surface and which is not involved in the movements of the valvular tissue during systole and diastole, the internal cover is more easily fastened to the internal surface of the frame.

In the particular embodiment shown in figure 8, the internal cover 19 is fastened, after introduction (indicated by the arrow B), at the upper and lower extremities of the frame 10 on the upper and lower zig-zag lines of the intercrossing bars 11. In fact, the fastening of the internal cover 19 on the zig-zag lines made by the intercrossing bars 11 of the frame allows an easier passage of blood from the aorta above the IV towards the coronary ostia. Indeed, the blood can find more space to flow into the coronary ostia by passing through the nadir of each triangular space made by two intercrossing bars 11, as indicated by the arrows A1 (see also figure 1b).

The fastening of the internal cover 19 on the extremities can be reinforced by various points of attachment on various parts of the internal surface of the frame 10. The internal cover 27 can be fastened by sewing, molding or gluing on the bars 11 of the frame.

Fastening the valvular tissue (and the cover tissue below) on the inside the frame, requires to work on the frame in its expanded presentation to have an access to the inside of this cylindric frame. In a preferred embodiment of the frame, this latter is expanded a first time for the fastening of the valvular tissue on its bars, then compressed back in a small size to be able to be introduced in an arterial introducer and finally expanded again by the balloon inflation.

Since it is aimed at being positioned in the heart after having been introduced by a catheterization technique by a transcutaneous route in a peripheral artery, mainly the femoral artery, the IV should preferably have the smallest possible external diameter. Ideally, it should be able to be introduced in the femoral artery through a 14 F (4,5 mm) size arterial introducer which is the size of the arterial introducer commonly used to perform an aortic dilatation. However, a 16 F (5,1 mm) or even a 18 F (5,7 mm) introducer could also be acceptable.

Above this size, the introduction of the IV in the femoral artery should probably be made by a surgical technique. This would be still quite acceptable since the surgical act would be a very light act which could be done by a surgeon with a simple local anaesthesia. It has to be reminded that this technique is used to position big metallic frames, about 24 F in size (7.64 mm in diameter), in the abdominal aorta for the treatment of aneurysms of the abdominal aorta. In that situation, this necessitate surgical repair of the artery after withdrawal of the sheath (M. D. Dake, New Engl. J Med. 1994;331:1729-34).

Ideally, an IV should be able to last several tenths of life years without defect, like the mechanical prosthetic valves which are currently implanted by the surgeons. Nevertheless, an implantable valve that would last at least ten years without risk of deterioration would be of great help for the treatment of elderly patients.

A valvular structure according to the invention is made of a supple and reinforced tissue which has such a thickness of less to be both thin to occupy as less as possible space in the compressed form of the valve, pliable, and also strong to stand the unceasing movements under the blood pressure changes during the heart beats. The valvular structure is capable of moving from its closed position to its opened position under the action of the force exerted by the movements of the blood during systole and diastole, without opposing any significant resistance to the blood displacements.

The material used for the tissue, which exhibits the above mentioned requirements, may be Teflon® or Dacron®, which are quite resistant to folding movements, at least when they are used to repair cardiac defects such as inter-atrial or interventricular defects or when they are used to repair a valve such as the mitral valve which is submitted to high pressures changes and movements during heart beats. Also, a main point is the inceasing systolo-diastolic movements of the valvular tissue, particularly at its junction with the rigid part of the IV, and it is therefore necessary to find the most possible resistant material tissue.

As mentioned previously, the valvular structure can also possibly be made with biological tissue such as the pericardium or with porcine leaflets, which are commonly used in bioprosthetic surgically implanted valves.

Moreover, the valvular prosthesis of the invention do not induce any significant thrombosis phenomenon during its stay in the blood flow and is biologically neutral.

To prevent the risk of thrombus formation and of clots emboli, a substance with anti-thrombic properties could be used, such as heparine, ticlopidine, phosphorylcholine, etc. either as a coating or incorporated into the material used for the implantable valve in particular for the valvular structure and/or for the internal cover.

The valvular structure of the invention can have several types of designs and shapes. Besides the example illustrated in figures 4 and 5, examples of strengthened valvular structures according to the invention are shown on figures 9 to 11, respectively in the closed (figures 9a, 10a, 11a) and in the opened state (figures 9b, 10b, 11b) to form a prosthetic valve according to the present invention. In those figures, the frame line is simplified to clarify the drawings.

To help initiating and finalizing the closure of the valvular structure, four strengthening struts 14 are slightly inclined from the basis to the upper part as compared to the central axis X'X of the structure, as shown in figures 9a and 9b. Accordingly, a patterned movement of the valvular structure, during the closing and the opening phasis, is initiated and performed. This patterned movement is, in the present case, an helicoïdal-type one, as suggested on Figures 9b and 10b by the circular arrow.

Figures 10a and 10b illustrate another embodiment to help the closure of the valvular structure and which also involves an helicoïdal movement. Represented by lines 22, inclined pleats are formed in the tissue to impart such a movement. As illustrated, these lines have an inclination from the basis to the upper part of the tissue 14. Pleats are formed by folding the tissue or by alterning thinner and thicker portions. The width and the number of those pleats are variable, and depend particularly of the type of material used. According to another example, these pleats 34 are combined with the above described inclined strengthening struts.

These reinforcing pleats and/or struts, rectilinear or inclined, would have the advantage to impart a reproductible movement and, accordingly, to avoid that the closure of the valvular structure ends up to a higgledy-piggledy collapse on the frame basis.

Another shape of the valvular structure, as illustrated on figures 11a and 11b comprises four portions, alternatively a main portion 23 and a more narrow portion 24. The main and the narrow portions are facing each other. Each portion has a isosceles trapezoidal shape. The main portions 23 are flexible but with some slight rigidity and the more narrow portions 24 are compliant and more supple and foldable. In this variety of designs, the two slightly rigid portions 23 allow to maintain the valvular structure closed during diastole by firmly applying each other their upper extremities, thus forming a slot-like closure 25. This particular embodiment needs less foldable tissue than in the previous embodiments and the closure of the valvular structure at time of early diastole does not have any tendency to collapse towards the aortic annulus.

Another design for the valvular structure is a combination of a cylindrical shape followed by a truncated shape.

This type of valvular structure is longer that the hyperboloïdal type, for instance 25 or 30 mm long, therefore out-passing the upper part of the metallic frame, by 10 to 20 mm. The cylindrical part corresponds to the metallic frame and remain inside it. The truncated conic shape is the upper part of the valvular structure, totally out-passing the upper extremity of the metallic frame. An advantage of such a design is that the balloon can be inflated only in the cylindrical part of the valvular structure, therefore without risk of stretching the truncated conical part of the upper diameter which is smaller than that of the inflated balloon.

The upper extremity of the cylindrical part having the same size than the lower extremity, there is no difference during the balloon inflation in the degree of the force exerted by the balloon on the lower and on the upper extremity of the valvular structure. Preferably, rectilinear reinforcing struts are used in this embodiment, to strengthen the valve structure and help its shutting without collapsing and inverting inside the left ventricle through the aortic annulus under the force of the diastolic pressure.

Two different processes for implanting a valve according to the present invention are shown respectively in Figures 13a to 13l with a unique balloon catheter, as illustrated in figures 12a and 12b and in Figures 15a to 15f, with a two-balloons catheter, as illustrated in figure 14.

The IV positioning in the aortic orifice and its expansion can be performed with the help of a unique substantially cylindrical balloon 0000000catheter 26 in the so-called unique-balloon catheterization technique.

In preparation to its introduction by transcutaneous route in the femoral artery, the IV 13 is, as illustrated in the perspective view of figure 10a in a compressed form crimpled on the balloon catheter 26. A central sectional view of the mounted IV 13 on the complete balloon catheter 26 is shown on Figure 12b.

The shaft 27f of the balloon dilatation catheter 26 is smallest as possible, i.e. a 7F (2,2 mm) or a 6 F (1,9 mm) size. The balloon 26 is mounted on the shaft 27 between two rings R. Moreover, the shaft 27 comprises a lumen 28 (figure 12b) as large as possible for inflation of the balloon 26 with diluted contrast to allow easy and fast inflation and deflation. It has also another lumen 29 able to accept a stiff guide wire 30, for example 0.036 to 0.038 inches (0,97 mm), to help the positioning of the implantable valve with precision.

The balloon 26 has for example a 3 to 4 cm length in its cylindrical part and the smallest possible size when completely deflated so that it will be able to be placed inside the folded valve which outside diameter ranges between about 4 and 5 mm. Therefore, the folded balloon preferably has at the most a section diameter of about 2.5 to 3 mm.

The balloon is therefore made in a very thin plastic material. It is inflated with saline containing a small amount of contrast dye in such a way to remain very fluid and visible when using X-ray.

However, the balloon 26 has to be sufficiently strong to resist the high pressure that it has to accept to be capable of expand the folded valvular structure 14 and the compressed frame in the stenosed aortic orifice considering that, although pre-dilated, the aortic orifice still exert a quite strong resistance to expansion because of the recoil phenomenon.

This procedure is shown in Figures 13a to 13e.

In opposition to the technique used when performing an usual aortic dilatation (without valve implantation), i.e., inflating maximally the balloon markedly above the nominal pressure, if possible up to burst it (which occurs always with a longitudinal tear, without deleterious consequence, and with the advantage of both exerting a maximal dilating force and restoring blood ejection instantaneously), the balloon inflated for expansion of an implantable valve should not burst in any case. Indeed, bursting of the balloon would involve a risk of incomplete valve expansion and wrong positioning. Therefore, the balloon should be very resistant to a very high pressure inflation. Furthermore, the balloon is inflated only up to the nominal pressure indicated by the maker with control of this pressure during inflation with use of a manometer. Such a relatively low pressure would be sufficient since prior to the IV positioning is performed, an efficacious dilatation of the stenosed aortic valve according to the usual technique with a maximally inflated balloon for example 20 mm or 25 mm in size in such a way to soften the distorted valvular tissue and facilitate the enlargement of the opening of the valve at time of IV implantation.

The implantation of the aortic valve 20 can be made in two steps, as follows.

The first step, as shown on figures 13a to 13f, consists in introducing the shaft 27 and balloon catheter 26 along the guide wire previously positioned in the ventricle 4 (figures 13a-13b). The dilatation of the stenosed aortic valve 1', 2' using a regular balloon catheter, according to the commonly performed procedure, i.e. with the guide wire 30 introduced in the ventricle 4 (figure 13a) and with maximal inflation of the balloon 26 (figures 13c to 13d) up to the bursting point. Dilatation is performed at least with a balloon having about 20 mm diameter, but it can be performed with a balloon having about 23 mm diameter so as to increase maximally the aortic orifice opening before implantation of the valve although the implantable valve is about 20 mm in diameter. This preliminary dilatation of the aortic orifice helps in limiting the force required to inflate the balloon used to expand the implantable valve and position it in the aortic orifice, and also in limiting the recoil of the aortic valve that occurs immediately after balloon deflation. The balloon is deflated (figure 13a) and pulled back from the wire guide 30 left inside the ventricle.

Owing to the marked recoil of the stenosed valve and also of the strong aortic annulus, the 20 mm diameter valve is forcefully maintained against the valvular remains at the level of the aortic annulus. The preliminary dilatation has another advantage in that it allows an easier expansion of the IV needing of a lower pressure balloon inflation which helps preventing damage of the valvular structure of the IV. This also facilitates the accurate positioning of the prosthetic valve.

The second step corresponds to the implantation of the valve 13 as shown on Figures 13g to 13l. The positioning of the IV needs to be precise at a near 2 or 3 mm, particularly as regard to the coronary ostia 6 which have to remain absolutely free of any obstruction by the valve 13 (figures 13k and 13l). As mentioned above, this is for example performed with the help of the image of the sus-valvular angiogram in the same projection fixed on an adjacent TV screen. The expansion and the positioning of the valve prosthesis 13 is performed within few seconds (15 to 20 as a whole at most) since during the maximal balloon inflation (which has to be maintained only very few seconds, 3, 4, 5) the aortic orifice is obstructed by the inflated balloon 31 and the cardiac output is zero (figure 13h). As for the pre-dilatation act itself, the balloon 26 is immediately deflated within less than 5 or 6 seconds (figure 13j) and, as soon as the deflation has clearly begun, the closing and opening states of the IV are active whereas the balloon is pulled back briskly in the aorta (figures 13j to 13l). In case the IV is not maximally expanded by the first inflation, it is possible to place again the balloon inside the IV and to reinflate it so as to reinforce the expansion of the IV.

The IV 13 can also be used in aortic regurgitation. This concerns more often younger patients rather than those with an aortic stenosis. The contraindication to surgical valve replacement is often not due to the old age of the patients but stems mainly from particular cases where the general status of the patient weak too weak to allow surgery, or because of associated pathological conditions. Apart of the fact that there is no need for a preliminary dilatation, the procedure of the valve implantation remains approximately the same. The balloon inflation inside the IV is chosen accordingly, taking also into account the fact that it is necessary to overdilate the aortic annulus to obtain a recoil phenomenon of the annulus after balloon deflation to help maintaining the IV in position without any risk of displacement.

However, the size of the expanded implantable valve is around 25 to 30 mm in diameter, or even bigger, because the aortic annulus is usually enlarged. A preliminary measurement of the annulus will have to be performed on the sus-valvular angiography and by echocardiography to determine the optimal size to choose.

The IV can be used in the mitral position, mainly in case of mitral regurgitation, but also in case of mitral stenosis. Here again, the IV 20 is only described when used only in cases of contraindication to surgical valve repair or replacement. The procedure is based on the same general principles though the route for the valve positioning is different, using the transseptal route, as for the commonly performed mitral dilatation procedure in mitral stenosis. The IV size is quite larger than for the aortic localization (about 30 to 35 mm in diameter when expanded or clearly above in case of large mitral annulus, a frequent occurrence in mitral insufficiency), to be capable of occupying the mitral area. A preliminary measurement of the mitral annulus performed to determine the optimal implantable valve size to choose. Since the introduction of the IV is performed through a venous route, almost always through the femoral vein which is quite large and distensable, the bigger size of the IV in its compressed presentation is not a drawback even if the diameter size is about 6 or 7 mm. Moreover, the problem of protection of the coronary ostia as encountered in the aortic position does not exist here which therefore makes the procedure easier to be performed.

Finally, the IV can be used to replace the tricuspid valve in patients with a tricuspid insufficiency. This procedure is simple to perform since the positioning of the IV is made by the venous route, using the shortest way to get in the right position at the level of the tricuspid orifice practically without any danger from clot migration during the procedure. A large implantable valve be used, with a diameter of about 40 mm or even bigger because the tricuspid annulus is often markedly dilated in tricuspid insufficiency. Here also, as in the mitral position, the compressed IV and the catheter used can be without inconvenience quite larger than for the aortic position because of the venous route used..

Furthermore, it has to be noted that the IV can be used also as a first step in the treatment of patients who have contraindication to surgery, when they are examined for the first time, but who could improve later on after correction of the initial hemodynamic failure. The IV procedure can be used as a bridge towards surgery for the patients in weak general condition expecting them to improve within the following weeks or months after the IV procedure in such a way that they can be treated by open heart surgery later on. In the same vein, the IV procedure can be used as a bridge towards surgical valve replacement or repair in the patients with a profoundly altered cardiac function that can improve secondarily owing to the hemodynamic improvement resulting from the correction of the initial valvular disease by the IV implantation.

Another technique for implantation of an aortic valve by transcutaneous catheterization uses a two-balloons catheter.

An example of this technique using the two parts IV with a two-balloons catheter 40 is shown on figure 14.

Two-balloons 26 and 26' are fixed on a unique catheter shaft 27, said balloons been separated by only 1 or 2 centimeters. The two-balloons are preferably short, i.e. about 2 to 2.5 cm long in their cylindrical part. The first balloon 26 to be used carries a first frame 10 aimed at scaffolding the stenosed aortic orifice after initial dilatation. This first balloon 26 is positioned on the aorta side, above the second balloon 26' which is positioned on the left ventricle side. The second balloon 26' carries the expandable valve 13 which is of the type above described made of a second frame 10' and a valvular structure 14 attached to said frame 10'. The difference is that the said second frame does not need to be as strong as the first one and is easier to expand with a low balloon pressure inflation which does not risk damaging the valvular structure 14.

This enlarges the choice for making a valvular structure without having to face two contradictory conditions:

  • 1) having a soft and mobile valvular structure 14 capable to of opening and closing freely in the blood stream without risk of being damaged by a balloon inflation
  • 2) needing a reinforced frame strong enough to be capable resisting without any damage to a strong pressure inflation of the expanding balloon.

The shaft 27 of this successive two-balloons catheter 40 comprises two lumens for successive and separate inflation of each balloon. Indeed, an additional lumen capable of allowing a fast inflation takes room in the shaft and obliges to enlarge the shaft. However, this enlargement of the shaft stops at the level of the first balloon 26 since, further to said first balloon, only one lumen is necessary to inflate the second balloon 26', at the level of the IV which is the biggest part of the device.

Another advantage of this two parts IV with a two-balloons catheter is that each set of implantable valve and balloon has a smaller external diameter since each element to be expanded, considered separately, is smaller than considered in combination. This allows obtaining more easily a final device with an external diameter 14 F.

The first balloon is sufficiently strong to avoid bursting even at a very high pressure inflation. This first balloon is mounted in the frame in its deflated position, prior to its introduction by the strong frame which is aimed to scaffold the dilated stenosed aortic valve. The size and shape of said frame is comparable to what has been described previously but said frame is calculated (in particular the material, the number and diameter of its bars are chosen by the person skilled in the art) to make sure that it will resist the recoil of the dilated valve and that it will be securely embedded in the remains of the native aortic valve.

The second balloon does not need to be as strong as the first one and, therefore, can be thinner, taking less room and being easier to expand with a lower pressure for balloon inflation. This second balloon 26' is mounted in the valve itself which, as in the preceding description, comprises a frame to support the valvular structure and said valvular structure.

Also, the second frame 10' does not need to be as strong as the first one. This frame can be slightly shorter, 10 mm instead of 12 mm, and its bars can be thinner (for instance ?). This frame can have an external surface a bit rough to allow a better fixation on the first frame when expanded. The bars may also have some hooks to fasten to the first frame.

The valvular structure is attached on said second frame and expanded by a relatively low pressure in the second balloon called hereafter the IV balloon. It does not need to be as strong as in the preceding case (IV in one part and unique balloon catheter technique) and, therefore, it takes less room and it has less risk to be damaged at time of expansion.

This technique is shown on figures 15a to 15f.

One of the problems relevant to the IV implantation procedure as described above, with the IV in one part, is the expansion at the same time by the same balloon inflation of both the frame and the valvular structure. Indeed, the frame is a solid element and the valvular structure is a relative weak one that could be damaged when squeezed by the inflated balloon.

Therefore, the valve implantation can be performed in two immediately successive steps. The first step (figures 15a-15b) corresponds to the expansion and the positioning of the first frame with the first balloon 26 inflation is performed at a high pressure inflation. The second step (figures 15d-15e) corresponds to the expansion and the positioning of the valvular structure 14 inside the frame 10' using the second balloon 26'. This second step follows the first one within few seconds because, in the time interval between the two steps, there is a total aortic regurgitation towards the left ventricle which is an hemodynamic condition that cannot be faced for more than a few heart beats, i.e. a few seconds, without inducing a massive pulmonary oedema and a drop to zero of the cardiac output.

The advantage of this two steps procedure would be to allow expansion and positioning of the frame part 10' of the IV 13 using a strong pressure inflation of the balloon 26' without risking damaging the valvular structure 14 which for its own expansion would need only a light pressure inflation.

The method is schematically detailed on figures 15a to 15f. A previous dilatation of the stenosed aortic valve is performed as an initial step of the procedure to prepare the distorted valve to facilitate the following steps:

  • 1/ positioning the double balloon catheter 40 with the first balloon 26 with the frame at the level of the aortic annulus 2a, the second IV balloon 26' being inside the left ventricle further the aortic annulus 2a (Figure 15a);
  • 2/ compression of the stenosed aortic valve 1', 2' with the first balloon 26 having a 20 mm, preferably with a 23 mm diameter, the balloon being inflated maximally up to the bursting point, to prepare the IV insertion (figure 15b). Inflation lasts few seconds (preferably 10 seconds at most) with the powerful pressure to expand the frame and forcefully embed of said frame in the remains of the dilated valve;
  • 3/ an immediate speedy deflation of said first balloon 26 follows (figure 15c); as soon as the balloon 26 is beginning to clearly deflate, the first frame 10 remaining attached to the stenosed valve 1', 2', the catheter 40 is pulled back to position the IV balloon 26' inside the previously expanded frame 26 (figure 15c in which the frame 10' is partially drawn for clarity purpose);
  • 4/ immediately after being well positioned, the IV balloon 26' is promptly inflated, to expand the IV 13 (figure 15c);
  • 5/ when the IV 13 is blocked inside the first frame 10, the IV balloon 26' is deflated (figure 18f).

Finally, the whole device has to be pulled out of the patient to obtain hemostasis of the femoral artery puncture hole.
The total duration of the successive steps, particularly the time during which the balloons are inflated, and the time during which the frame is expanded whereas the valve has not yet been positioned and expanded, is about 20 to 30 seconds. This is feasible if the balloons are inflated and deflated within very few seconds, 6 to 8 for instance. This is permitted if the lumen of the shaft can be sufficiently large, taking into account the inescapable small diameter size of the shaft. This can also be facilitated by a device allowing producing instantaneously a strong inflation or deflation pressure.

Claims (22)

  1. A valve prosthesis for implantation in a body channel, the prosthesis comprising a collapsible valvular structure (14), and an expandable frame (10, 10') on which said valvular structure (14) is mounted, said valvular structure (14) being composed of a valvular tissue compatible with the human body and blood, the valvular tissue being sufficiently supple and resistant to allow said valvular structure (14) to be deformed from a closed state to an opened state to allow a body fluid exerting pressure on the valvular structure (14) to flow, wherein said valvular tissue forms a continuous surface and is provided with guiding means formed or incorporated within, said guiding means creating stiffened zones which induce said valvular structure (14) to follow a patterned movement in its expantion to its opened state and in its turning back to its closed state, providing therefore a structure sufficiently rigit to prevent eversion.
  2. A prosthetic valve according to claim 1, characterized in that an internal cover (19) is coupled to the valvular structure (14) and placed between said valvular structure (14) and the internal wall of the structure of the frame (10) to prevent any passage of the body fluid through said structure.
  3. A prosthetic valve according to claim 2, characterized in that both the valvular structure (14) and the internal cover (19) are all of a piece.
  4. A prosthetic valve according to claim 2, characterized in that the valvular structure and/or the internal cover are coated or are incorporated with an anti-thrombic substance.
  5. A prosthetic valve according to claim 2, characterized in that said valvular structure (14) covers the full length of the internal surface of the frame (10) or only a part of said internal surface.
  6. A prosthetic valve according to claim 1 or 2, characterized in that said valvular structure (14) has a substantially truncated hyperboloïdal shape in its opened state.
  7. A prosthetic valve according to any preceeding claims characterized in that said guiding means comprise strips inclined from the basis (15) to the upper extremity (16) of the valvular structure (14) when compared to the central symmetry axis (XX') of the valvular structure (14), the curvature of said guiding means being concave towards said upper extremity (16) to impart an helicoidal movement to the valvular structure (14) when compared to the central axis (XX') of the valvular structure (14).
  8. A prosthetic valve according to anyone of claims 1 to 6, characterized in that said guiding means are rectilinear (17) in plans including the central axis (X'X) from the basis (15) to the upper extremity (16) of the valvular structure (14).
  9. A prosthetic valve according to claim 7 or 8, characterized in that said guiding means comprise pleats extending from the basis (15) of the valvular structure (14) to the upper extremity (16) of said valvular structure (14).
  10. A prosthetic valve according to claim 7 or 8, characterized in that said guiding means comprise strengthening struts (17, 21), preferably at least 3, formed from thickened zones or incorporated strips of stiffening material.
  11. A prosthetic valve according to anyone of claims 1 to 6, characterized in that said stiffened zones are main parts (23) of trapezoidal shape, preferably two main parts formed symmetrically with regard to the central axis (XX') of the valvular structure (14), separated by less rigid parts (24), and in that said guiding means are of the type rectilinear according to claim 8.
  12. A prosthetic valve according to claim 11, characterized in that each of said main parts (23) occupies approximately one third of the circumference of the upper part of the valvular structure (14) when this latter is in its open position.
  13. A prosthetic valve according to claim 11 or 12, characterized in that the main parts (23) are thickened zones and the other parts (24) are thinner zones.
  14. A prosthetic valve according to anyone of claims 1 to 13, characterized in that said valvular tissue is made of synthetic biocompatible material as Teflon® or Dacron®, or made of biological material as pericardium, porcine leaflets and the like.
  15. A prosthetic valve according to anyone of claims 1 to 14, characterized in that said valvular structure (14) is fastened to the frame (10) by sewing, by molding or by gluing, to prevent regurgitation of said body fluid between the frame (10) and the valvular structure (14).
  16. A prosthetic valve according to anyone of claims 1 to 15, characterized in that said frame (10) is expandable from a size of the order or 4 to 5 millimeters to a size of 20 to 35 mm in diameter.
  17. A prosthetic valve according to anyone of claims 1 to 15, characterized in that said frame (10), in its fully expanded frame, has a height of approximately between 10 and 15 mm and in its fully compressed frame, a height of approximately 20 mm.
  18. A prosthetic valve according to anyone of claims 1 to 17, characterized in that said frame (10) is made in material which is distinguishable from biological tissue by non invasive imaging techniques.
  19. A prosthetic valve according to anyone of claims 1 to 18, characterized in that said frame (10) is a foldable plastic or stainless metal structure made of intercrossing, linear bars, preferably rounded and smooth.
  20. A prosthetic valve according to claim 19, characterized in that the size and the number of the bars are determined to give both the maximal rigidity when said frame (10) is in its expanded state and the smallest volume when the frame (10) is in its compressed state.
  21. A prosthetic valve according to anyone of claims 1 to 20 characterized in that the frame (10) has a concave shape comprising projecting curved bars at the extremities (12).
  22. A prosthetic valve according to anyone of claims 1 to 21, characterized in that a first frame (10) is coupled with another frame (10') which has bars of size substantially lower than said first frame (10) and which is embedded inside this latter, along a common shaft (27), the first frame being compressed with a first balloon catheter (26) and the second frame (26') being a part of a prosthetic valve (13) according to any one of the preceeding claims, each frame squeezed on each of the two balloons in order to constitute a double balloon catheter (40).
EP19960402929 1996-12-31 1996-12-31 Valve prosthesis for implantation in body channels Withdrawn EP0850607A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP19960402929 EP0850607A1 (en) 1996-12-31 1996-12-31 Valve prosthesis for implantation in body channels

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
EP19960402929 EP0850607A1 (en) 1996-12-31 1996-12-31 Valve prosthesis for implantation in body channels
ES10012627T ES2404141T3 (en) 1996-12-31 1997-12-31 valve prosthesis for implantation in body channels
EP20100012626 EP2260796B1 (en) 1996-12-31 1997-12-31 A prosthetic valve assembly for implantation in a stenotic native aortic valve
EP19970953935 EP0967939A1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels
EP20080016624 EP2000115B2 (en) 1996-12-31 1997-12-31 A prosthetic valve assembly
ES10012626T ES2406086T3 (en) 1996-12-31 1997-12-31 valve prosthesis for implantation in body channels
ES10012954T ES2564058T3 (en) 1996-12-31 1997-12-31 Method of manufacturing a prosthetic valve assembly
PCT/EP1997/007337 WO1998029057A1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels
EP20100184036 EP2260798B1 (en) 1996-12-31 1997-12-31 Cardiac valve prosthesis having internal cover for preventing regurgitation
ES08016624T ES2365880T5 (en) 1996-12-31 1997-12-31 An assembly prosthetic valve
EP20100012954 EP2263609B1 (en) 1996-12-31 1997-12-31 Method of manufacturing a prosthetic valve assembly
CA 2276527 CA2276527A1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels
EP20050024006 EP1621162B1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels
EP20100012627 EP2260797B1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels
ES10184036T ES2425320T3 (en) 1996-12-31 1997-12-31 heart valve prosthesis having inner cover to prevent regurgitation
DE1997640189 DE69740189D1 (en) 1996-12-31 1997-12-31 The prosthetic heart valve arrangement
ES05024006T ES2385890T3 (en) 1996-12-31 1997-12-31 prosthetic valve for implantation in body channels
US09795803 US20010010017A1 (en) 1996-12-31 2001-02-28 Alve prosthesis for implantation in body channels
US09795802 US20010007956A1 (en) 1996-12-31 2001-02-28 Valve prosthesis for implantation in body channels
US10139741 US6908481B2 (en) 1996-12-31 2002-05-02 Value prosthesis for implantation in body channels
US10202458 US7846203B2 (en) 1996-12-31 2002-07-23 Implanting a stent valve prosthesis at the native aortic valve
US11110402 US20090132032A9 (en) 1996-12-31 2005-04-20 Valve prosthesis for implantation in body channels
US11139356 US7585321B2 (en) 1996-12-31 2005-05-27 Methods of implanting a prosthetic heart valve within a native heart valve
US11692890 US8591575B2 (en) 1996-12-31 2007-03-28 Method of dilating a stenotic aortic valve and implanting a prosthetic valve
US11942690 US7846204B2 (en) 1996-12-31 2007-11-19 Aortic valve prosthesis having natural tissue and an internal cover
US12915538 US8002825B2 (en) 1996-12-31 2010-10-29 Implantable prosthetic valve for treating aortic stenosis
US12953977 US8057540B2 (en) 1996-12-31 2010-11-24 Method of treating aortic stenosis using an implantable prosthetic valve
US13278813 US9486312B2 (en) 1996-12-31 2011-10-21 Method of manufacturing a prosthetic valve
US14089332 US9095432B2 (en) 1996-12-31 2013-11-25 Collapsible prosthetic valve having an internal cover
US14805179 US9629714B2 (en) 1996-12-31 2015-07-21 Collapsible prosthetic valve

Publications (1)

Publication Number Publication Date
EP0850607A1 true true EP0850607A1 (en) 1998-07-01

Family

ID=8225366

Family Applications (8)

Application Number Title Priority Date Filing Date
EP19960402929 Withdrawn EP0850607A1 (en) 1996-12-31 1996-12-31 Valve prosthesis for implantation in body channels
EP20080016624 Expired - Lifetime EP2000115B2 (en) 1996-12-31 1997-12-31 A prosthetic valve assembly
EP20100012626 Revoked EP2260796B1 (en) 1996-12-31 1997-12-31 A prosthetic valve assembly for implantation in a stenotic native aortic valve
EP20050024006 Expired - Lifetime EP1621162B1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels
EP20100184036 Expired - Lifetime EP2260798B1 (en) 1996-12-31 1997-12-31 Cardiac valve prosthesis having internal cover for preventing regurgitation
EP20100012627 Expired - Lifetime EP2260797B1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels
EP20100012954 Expired - Lifetime EP2263609B1 (en) 1996-12-31 1997-12-31 Method of manufacturing a prosthetic valve assembly
EP19970953935 Withdrawn EP0967939A1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels

Family Applications After (7)

Application Number Title Priority Date Filing Date
EP20080016624 Expired - Lifetime EP2000115B2 (en) 1996-12-31 1997-12-31 A prosthetic valve assembly
EP20100012626 Revoked EP2260796B1 (en) 1996-12-31 1997-12-31 A prosthetic valve assembly for implantation in a stenotic native aortic valve
EP20050024006 Expired - Lifetime EP1621162B1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels
EP20100184036 Expired - Lifetime EP2260798B1 (en) 1996-12-31 1997-12-31 Cardiac valve prosthesis having internal cover for preventing regurgitation
EP20100012627 Expired - Lifetime EP2260797B1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels
EP20100012954 Expired - Lifetime EP2263609B1 (en) 1996-12-31 1997-12-31 Method of manufacturing a prosthetic valve assembly
EP19970953935 Withdrawn EP0967939A1 (en) 1996-12-31 1997-12-31 Valve prosthesis for implantation in body channels

Country Status (6)

Country Link
US (13) US20010010017A1 (en)
EP (8) EP0850607A1 (en)
CA (1) CA2276527A1 (en)
DE (1) DE69740189D1 (en)
ES (6) ES2425320T3 (en)
WO (1) WO1998029057A1 (en)

Cited By (234)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023006A1 (en) * 1998-10-16 2000-04-27 Sulzer Carbomedics Inc. Elastic valve with partially exposed stent
FR2788217A1 (en) 1999-01-12 2000-07-13 Brice Letac Implantable prosthetic valve by catheterization, or surgically
WO2000047139A1 (en) * 1999-02-10 2000-08-17 Heartport, Inc. Methods and devices for implanting cardiac valves
WO2001028459A1 (en) * 1999-10-21 2001-04-26 Scimed Life Systems, Inc. Implantable prosthetic valve
NL1014095C2 (en) * 2000-01-17 2001-07-18 Cornelis Hendrikus Anna Witten Implant valve for implantation in a blood vessel.
WO2001054625A1 (en) * 2000-01-31 2001-08-02 Cook Biotech Incorporated Stent valves and uses of same
EP1154738A1 (en) * 1999-01-27 2001-11-21 Viacor Incorporated Cardiac valve procedure methods and devices
WO2001049213A3 (en) * 1999-12-31 2002-01-24 Advanced Bio Prosthetic Surfac Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
WO2002022054A1 (en) * 2000-09-12 2002-03-21 Gabbay S Valvular prosthesis and method of using same
WO2002024119A1 (en) * 2000-09-21 2002-03-28 St. Jude Medical, Inc. Valved prostheses with reinforced polymer leaflets
EP1229865A1 (en) * 1999-09-10 2002-08-14 Francisco J. Osse Endovascular treatment for chronic venous insufficiency
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
WO2003003943A2 (en) 2001-07-03 2003-01-16 Advanced Bio Prosthetic Surfaces, Ltd Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US6508833B2 (en) 1998-06-02 2003-01-21 Cook Incorporated Multiple-sided intraluminal medical device
WO2003022183A1 (en) * 2001-09-13 2003-03-20 Edwards Lifesciences Corporation Apparatuses for deploying minimally-invasive heart valves
US6562069B2 (en) 2001-09-19 2003-05-13 St. Jude Medical, Inc. Polymer leaflet designs for medical devices
US6705317B2 (en) 1999-10-22 2004-03-16 3M Innovative Properties Company Retention assembly with compression element and method of use
WO2004034933A2 (en) * 2002-05-10 2004-04-29 Cordis Corporation Frame based unidirectional flow prosthetic implant
JP2004514467A (en) * 2000-06-26 2004-05-20 レックス メディカル リミテッド パートナーシップ Vascular device for close to a small leaf-like valvular
EP1441672A1 (en) * 2001-10-11 2004-08-04 Percutaneous Valve Technologies Implantable prosthetic valve
WO2004082537A1 (en) * 2003-03-21 2004-09-30 Raymond Andrieu Intraparietal aortic valve reinforcement device and reinforced aortic valve
WO2004096100A1 (en) * 2003-04-24 2004-11-11 Cook Incorporated Artificial valve prosthesis with improved flow dynamics
US6869444B2 (en) 2000-05-22 2005-03-22 Shlomo Gabbay Low invasive implantable cardiac prosthesis and method for helping improve operation of a heart valve
WO2005070343A1 (en) * 2003-12-23 2005-08-04 Laboratoires Perouse Kit which is intended to be implanted in a conduit
US6953332B1 (en) 2000-11-28 2005-10-11 St. Jude Medical, Inc. Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
FR2883721A1 (en) * 2005-04-05 2006-10-06 Perouse Soc Par Actions Simpli Vascular endoprosthetic device comprising prosthetic valve implanted in stent, includes variable cross-section pieces forming shoulders to block axial displacement and ensure accurate mounting
US7118600B2 (en) * 1998-08-31 2006-10-10 Wilson-Cook Medical, Inc. Prosthesis having a sleeve valve
US7160322B2 (en) 2003-08-13 2007-01-09 Shlomo Gabbay Implantable cardiac prosthesis for mitigating prolapse of a heart valve
US7217287B2 (en) * 2002-08-28 2007-05-15 Heart Leaflet Technologies, Inc. Method of treating diseased valve
US7252682B2 (en) 2001-07-04 2007-08-07 Corevalve, S.A. Kit enabling a prosthetic valve to be placed in a body enabling a prosthetic valve to be put into place in a duct in the body
JP2007522829A (en) * 2003-10-02 2007-08-16 エドワーズ ライフサイエンシーズ コーポレイションEdwards Lifesciences Corporation Implantable prosthetic valve with a non-laminar flow
US7270675B2 (en) 2002-05-10 2007-09-18 Cordis Corporation Method of forming a tubular membrane on a structural frame
EP1849440A1 (en) * 2006-04-28 2007-10-31 Younes Boudjemline Vascular stents with varying diameter
EP1900343A3 (en) * 2000-01-31 2008-03-26 Cook Biotech, Inc. Stent valves and uses of same
US7351256B2 (en) 2002-05-10 2008-04-01 Cordis Corporation Frame based unidirectional flow prosthetic implant
US7452371B2 (en) 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
JP2008539985A (en) * 2005-05-13 2008-11-20 コアヴァルヴ,インコーポレイテッド Prosthetic heart valves as well as methods of making and using the same
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
EP2000116A1 (en) 2007-06-08 2008-12-10 Laboratoires perouse Kit designed to be implanted in a blood vessel
US7470284B2 (en) 1999-01-27 2008-12-30 Medtronic, Inc. Cardiac valve procedure methods and devices
US7485141B2 (en) 2002-05-10 2009-02-03 Cordis Corporation Method of placing a tubular membrane on a structural frame
US7682390B2 (en) * 2001-07-31 2010-03-23 Medtronic, Inc. Assembly for setting a valve prosthesis in a corporeal duct
US7722667B1 (en) * 1998-04-20 2010-05-25 St. Jude Medical, Inc. Two piece bioprosthetic heart valve with matching outer frame and inner valve
US7789909B2 (en) 1990-05-18 2010-09-07 Edwards Lifesciences Ag System for implanting a valve prosthesis
US7815677B2 (en) 2007-07-09 2010-10-19 Leman Cardiovascular Sa Reinforcement device for a biological valve and reinforced biological valve
US7828839B2 (en) 2002-05-16 2010-11-09 Cook Incorporated Flexible barb for anchoring a prosthesis
US7846203B2 (en) 1996-12-31 2010-12-07 Edwards Lifesciences Pvt, Inc. Implanting a stent valve prosthesis at the native aortic valve
US7857845B2 (en) 2005-02-10 2010-12-28 Sorin Biomedica Cardio S.R.L. Cardiac-valve prosthesis
US7871436B2 (en) 2007-02-16 2011-01-18 Medtronic, Inc. Replacement prosthetic heart valves and methods of implantation
US7918882B2 (en) 1999-06-02 2011-04-05 Cook Medical Technologies Llc Implantable vascular device comprising a bioabsorbable frame
US7927369B2 (en) 2005-03-01 2011-04-19 Leman Cardiovascular Sa Intraparietal reinforcing device for biological cardiac prosthesis and reinforced biological heart valve prosthesis
US7981153B2 (en) * 2002-12-20 2011-07-19 Medtronic, Inc. Biologically implantable prosthesis methods of using
US7993392B2 (en) 2006-12-19 2011-08-09 Sorin Biomedica Cardio S.R.L. Instrument and method for in situ deployment of cardiac valve prostheses
US7993394B2 (en) 2008-06-06 2011-08-09 Ilia Hariton Low profile transcatheter heart valve
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US8038708B2 (en) 2001-02-05 2011-10-18 Cook Medical Technologies Llc Implantable device with remodelable material and covering material
US8052750B2 (en) 2006-09-19 2011-11-08 Medtronic Ventor Technologies Ltd Valve prosthesis fixation techniques using sandwiching
US8057539B2 (en) 2006-12-19 2011-11-15 Sorin Biomedica Cardio S.R.L. System for in situ positioning of cardiac valve prostheses without occluding blood flow
USD648854S1 (en) 2010-09-20 2011-11-15 St. Jude Medical, Inc. Commissure points
US8075615B2 (en) 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
USD652926S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Forked end
USD652927S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Surgical stent
USD653342S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Stent connections
USD653341S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical stent
USD653343S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical cuff
US8109996B2 (en) 2004-03-03 2012-02-07 Sorin Biomedica Cardio, S.R.L. Minimally-invasive cardiac-valve prosthesis
USD654170S1 (en) 2010-09-20 2012-02-14 St. Jude Medical, Inc. Stent connections
USD654169S1 (en) 2010-09-20 2012-02-14 St. Jude Medical Inc. Forked ends
US8114154B2 (en) 2007-09-07 2012-02-14 Sorin Biomedica Cardio S.R.L. Fluid-filled delivery system for in situ deployment of cardiac valve prostheses
US8157857B2 (en) 2003-04-24 2012-04-17 Cook Medical Technologies Llc Intralumenally-implantable frames
USD660433S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Surgical stent assembly
USD660432S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Commissure point
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
USD660967S1 (en) 2010-09-20 2012-05-29 St. Jude Medical, Inc. Surgical stent
US8206438B2 (en) 2001-03-23 2012-06-26 Edwards Lifesciences Corporation Prosthetic heart valve having flared outflow section
US8231670B2 (en) 2003-12-23 2012-07-31 Sadra Medical, Inc. Repositionable heart valve and method
US8236049B2 (en) 2008-06-20 2012-08-07 Edwards Lifesciences Corporation Multipiece prosthetic mitral valve and method
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US8246678B2 (en) 2003-12-23 2012-08-21 Sadra Medicl, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8252052B2 (en) 2003-12-23 2012-08-28 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8252051B2 (en) 2009-02-25 2012-08-28 Edwards Lifesciences Corporation Method of implanting a prosthetic valve in a mitral valve with pulmonary vein anchoring
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8312825B2 (en) 2008-04-23 2012-11-20 Medtronic, Inc. Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US8328868B2 (en) 2004-11-05 2012-12-11 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US8353953B2 (en) 2009-05-13 2013-01-15 Sorin Biomedica Cardio, S.R.L. Device for the in situ delivery of heart valves
US8403982B2 (en) 2009-05-13 2013-03-26 Sorin Group Italia S.R.L. Device for the in situ delivery of heart valves
US8425593B2 (en) 2007-09-26 2013-04-23 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8458879B2 (en) 2001-07-03 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Method of fabricating an implantable medical device
USD684692S1 (en) 2010-09-20 2013-06-18 St. Jude Medical, Inc. Forked ends
US8500802B2 (en) 2005-04-08 2013-08-06 Medtronic, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
US8506620B2 (en) 2005-09-26 2013-08-13 Medtronic, Inc. Prosthetic cardiac and venous valves
US8512397B2 (en) 2009-04-27 2013-08-20 Sorin Group Italia S.R.L. Prosthetic vascular conduit
US8512403B2 (en) * 2003-05-20 2013-08-20 The Cleveland Clinic Foundation Annuloplasty ring with wing members for repair of a cardiac valve
US8562672B2 (en) 2004-11-19 2013-10-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
US8568475B2 (en) 2010-10-05 2013-10-29 Edwards Lifesciences Corporation Spiraled commissure attachment for prosthetic valve
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US8623076B2 (en) 2003-12-23 2014-01-07 Sadra Medical, Inc. Low profile heart valve and delivery system
US8628566B2 (en) 2008-01-24 2014-01-14 Medtronic, Inc. Stents for prosthetic heart valves
US8652204B2 (en) 2010-04-01 2014-02-18 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US8668733B2 (en) 2004-06-16 2014-03-11 Sadra Medical, Inc. Everting heart valve
US8685084B2 (en) 2011-12-29 2014-04-01 Sorin Group Italia S.R.L. Prosthetic vascular conduit and assembly method
US8696743B2 (en) 2008-04-23 2014-04-15 Medtronic, Inc. Tissue attachment devices and methods for prosthetic heart valves
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
US8721713B2 (en) 2002-04-23 2014-05-13 Medtronic, Inc. System for implanting a replacement valve
US8778018B2 (en) 2003-03-18 2014-07-15 Mario M. Iobbi Method of implanting a minimally-invasive heart valve with cusp positioners
US8778019B2 (en) 2010-09-17 2014-07-15 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and method for transcatheter heart valve delivery
US8784480B2 (en) 2008-02-29 2014-07-22 Edwards Lifesciences Corporation Expandable member for deploying a prosthetic device
US8784481B2 (en) 2007-09-28 2014-07-22 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
US8808356B2 (en) 2008-07-15 2014-08-19 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US8808367B2 (en) 2007-09-07 2014-08-19 Sorin Group Italia S.R.L. Prosthetic valve delivery system including retrograde/antegrade approach
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
US8814931B2 (en) 2010-08-24 2014-08-26 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery systems
US8821569B2 (en) 2006-04-29 2014-09-02 Medtronic, Inc. Multiple component prosthetic heart valve assemblies and methods for delivering them
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US8834563B2 (en) 2008-12-23 2014-09-16 Sorin Group Italia S.R.L. Expandable prosthetic valve having anchoring appendages
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US8840661B2 (en) 2008-05-16 2014-09-23 Sorin Group Italia S.R.L. Atraumatic prosthetic heart valve prosthesis
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US8858620B2 (en) 2003-12-23 2014-10-14 Sadra Medical Inc. Methods and apparatus for endovascularly replacing a heart valve
US8894703B2 (en) 2003-12-23 2014-11-25 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US8915959B2 (en) 1991-07-16 2014-12-23 Heartport, Inc. Endovascular aortic valve replacement
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
US8998976B2 (en) 2011-07-12 2015-04-07 Boston Scientific Scimed, Inc. Coupling system for medical devices
US9005279B2 (en) 2010-11-12 2015-04-14 Shlomo Gabbay Beating heart buttress and implantation method to prevent prolapse of a heart valve
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US9011521B2 (en) 2003-12-23 2015-04-21 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9011527B2 (en) 2010-09-20 2015-04-21 St. Jude Medical, Cardiology Division, Inc. Valve leaflet attachment in collapsible prosthetic valves
US9028545B2 (en) 2005-06-13 2015-05-12 Edwards Lifesciences Corporation Method of delivering a prosthetic heart valve
USD730520S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
US9039759B2 (en) 2010-08-24 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
USD730521S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
US9061119B2 (en) 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
US9078781B2 (en) 2006-01-11 2015-07-14 Medtronic, Inc. Sterile cover for compressible stents used in percutaneous device delivery systems
US9078749B2 (en) 2007-09-13 2015-07-14 Georg Lutter Truncated cone heart valve stent
US9089422B2 (en) 2008-01-24 2015-07-28 Medtronic, Inc. Markers for prosthetic heart valves
US9114008B2 (en) 2006-12-22 2015-08-25 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method for making the same
US9119716B2 (en) 2011-07-27 2015-09-01 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US9161836B2 (en) 2011-02-14 2015-10-20 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US9168105B2 (en) 2009-05-13 2015-10-27 Sorin Group Italia S.R.L. Device for surgical interventions
US9168129B2 (en) 2013-02-12 2015-10-27 Edwards Lifesciences Corporation Artificial heart valve with scalloped frame design
US9168131B2 (en) 2011-12-09 2015-10-27 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
US9186238B2 (en) 2013-01-29 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Aortic great vessel protection
US9241792B2 (en) 2008-02-29 2016-01-26 Edwards Lifesciences Corporation Two-step heart valve implantation
US9241791B2 (en) 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
US9248017B2 (en) 2010-05-21 2016-02-02 Sorin Group Italia S.R.L. Support device for valve prostheses and corresponding kit
EP2979664A1 (en) 2014-08-01 2016-02-03 Alvimedica Tibbi Ürünler Sanayi Ve Dis Ticaret A.S Aortic valve prosthesis, particularly suitable for transcatheter implantation
US9289289B2 (en) 2011-02-14 2016-03-22 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US9289292B2 (en) 2012-06-28 2016-03-22 St. Jude Medical, Cardiology Division, Inc. Valve cuff support
US9289282B2 (en) 2011-05-31 2016-03-22 Edwards Lifesciences Corporation System and method for treating valve insufficiency or vessel dilatation
US9301840B2 (en) 2008-10-10 2016-04-05 Edwards Lifesciences Corporation Expandable introducer sheath
US9314163B2 (en) 2013-01-29 2016-04-19 St. Jude Medical, Cardiology Division, Inc. Tissue sensing device for sutureless valve selection
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
US9326853B2 (en) 2010-07-23 2016-05-03 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US9333100B2 (en) 2008-01-24 2016-05-10 Medtronic, Inc. Stents for prosthetic heart valves
US9339274B2 (en) 2013-03-12 2016-05-17 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
US9370421B2 (en) 2011-12-03 2016-06-21 Boston Scientific Scimed, Inc. Medical device handle
US9375312B2 (en) 2010-07-09 2016-06-28 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US9393110B2 (en) 2010-10-05 2016-07-19 Edwards Lifesciences Corporation Prosthetic heart valve
CN105792780A (en) * 2013-11-22 2016-07-20 爱德华兹生命科学公司 Aortic insufficiency repair device and method
US9398951B2 (en) 2013-03-12 2016-07-26 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US9414918B2 (en) 2012-09-06 2016-08-16 Edwards Lifesciences Corporation Heart valve sealing devices
US9415225B2 (en) 2005-04-25 2016-08-16 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
EP3067075A1 (en) 2015-03-10 2016-09-14 Carmat Tissue stent and method for manufacturing same
US9480563B2 (en) 2013-03-08 2016-11-01 St. Jude Medical, Cardiology Division, Inc. Valve holder with leaflet protection
US9510942B2 (en) 2007-12-14 2016-12-06 Edwards Lifesciences Corporation Leaflet attachment frame for a prosthetic valve
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9532868B2 (en) 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US9539092B2 (en) 2005-10-18 2017-01-10 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US9549818B2 (en) 2013-11-12 2017-01-24 St. Jude Medical, Cardiology Division, Inc. Pneumatically power-assisted tavi delivery system
US9554902B2 (en) 2012-06-28 2017-01-31 St. Jude Medical, Cardiology Division, Inc. Leaflet in configuration for function in various shapes and sizes
US9597185B2 (en) 2013-12-19 2017-03-21 St. Jude Medical, Cardiology Division, Inc. Leaflet-cuff attachments for prosthetic heart valve
US9610157B2 (en) 2014-03-21 2017-04-04 St. Jude Medical, Cardiology Division, Inc. Leaflet abrasion mitigation
US9615920B2 (en) 2012-06-29 2017-04-11 St. Jude Medical, Cardiology Divisions, Inc. Commissure attachment feature for prosthetic heart valve
US9636222B2 (en) 2013-03-12 2017-05-02 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak protection
US9655719B2 (en) 2013-01-29 2017-05-23 St. Jude Medical, Cardiology Division, Inc. Surgical heart valve flexible stent frame stiffener
US9668858B2 (en) 2014-05-16 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve with paravalvular leak sealing ring
US9668856B2 (en) 2013-06-26 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Puckering seal for reduced paravalvular leakage
US9668857B2 (en) 2013-11-06 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
US9700409B2 (en) 2013-11-06 2017-07-11 St. Jude Medical, Cardiology Division, Inc. Reduced profile prosthetic heart valve
US9717594B2 (en) 2009-07-14 2017-08-01 Edwards Lifesciences Corporation Methods of valve delivery on a beating heart
US9737264B2 (en) 2014-08-18 2017-08-22 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
US9763778B2 (en) 2014-03-18 2017-09-19 St. Jude Medical, Cardiology Division, Inc. Aortic insufficiency valve percutaneous valve anchoring
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US9795476B2 (en) 2010-06-17 2017-10-24 St. Jude Medical, Llc Collapsible heart valve with angled frame
US9801721B2 (en) 2012-10-12 2017-10-31 St. Jude Medical, Cardiology Division, Inc. Sizing device and method of positioning a prosthetic heart valve
US9808342B2 (en) 2012-07-03 2017-11-07 St. Jude Medical, Cardiology Division, Inc. Balloon sizing device and method of positioning a prosthetic heart valve
US9808201B2 (en) 2014-08-18 2017-11-07 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
USD802764S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
USD802766S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
USD802765S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
US9844435B2 (en) 2013-03-01 2017-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve replacement
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
US9855140B2 (en) 2014-06-10 2018-01-02 St. Jude Medical, Cardiology Division, Inc. Stent cell bridge for cuff attachment
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
US9867611B2 (en) 2013-09-05 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Anchoring studs for transcatheter valve implantation
US9867556B2 (en) 2014-02-07 2018-01-16 St. Jude Medical, Cardiology Division, Inc. System and method for assessing dimensions and eccentricity of valve annulus for trans-catheter valve implantation
US9867701B2 (en) 2011-08-18 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Devices and methods for transcatheter heart valve delivery
US9867700B2 (en) 2013-05-20 2018-01-16 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US9867697B2 (en) 2013-03-12 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for a paravalvular leak protection
US9889004B2 (en) 2013-11-19 2018-02-13 St. Jude Medical, Cardiology Division, Inc. Sealing structures for paravalvular leak protection
US9901470B2 (en) 2013-03-01 2018-02-27 St. Jude Medical, Cardiology Division, Inc. Methods of repositioning a transcatheter heart valve after full deployment
US9901445B2 (en) 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
US9901444B2 (en) 2013-12-17 2018-02-27 Edwards Lifesciences Corporation Inverted valve structure
US9913715B2 (en) 2013-11-06 2018-03-13 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
US9956384B2 (en) 2014-01-24 2018-05-01 Cook Medical Technologies Llc Articulating balloon catheter and method for using the same
US9962260B2 (en) 2015-03-24 2018-05-08 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
US9974650B2 (en) 2015-07-14 2018-05-22 Edwards Lifesciences Corporation Prosthetic heart valve
US10004597B2 (en) 2012-07-03 2018-06-26 St. Jude Medical, Cardiology Division, Inc. Stent and implantable valve incorporating same
US10010417B2 (en) 2015-04-16 2018-07-03 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10016272B2 (en) 2014-09-12 2018-07-10 Mitral Valve Technologies Sarl Mitral repair and replacement devices and methods
US10016276B2 (en) 2012-11-21 2018-07-10 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic heart valves
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
US10052198B2 (en) 2013-08-14 2018-08-21 Mitral Valve Technologies Sarl Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device
US10052199B2 (en) 2014-02-21 2018-08-21 Mitral Valve Technologies Sarl Devices, systems and methods for delivering a prosthetic mitral valve and anchoring device
US10058420B2 (en) 2014-02-18 2018-08-28 Edwards Lifesciences Corporation Flexible commissure frame
US10058424B2 (en) 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
US10058313B2 (en) 2011-05-24 2018-08-28 Sorin Group Italia S.R.L. Transapical valve replacement
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10070954B2 (en) 2015-03-24 2018-09-11 St. Jude Medical, Cardiology Division, Inc. Mitral heart valve replacement
US10076638B2 (en) 2014-12-05 2018-09-18 Edwards Lifesciences Corporation Steerable catheter with pull wire
US10080652B2 (en) 2015-03-13 2018-09-25 Boston Scientific Scimed, Inc. Prosthetic heart valve having an improved tubular seal
US10085834B2 (en) 2014-03-18 2018-10-02 St. Jude Medical, Cardiology Divsion, Inc. Mitral valve replacement toggle cell securement

Families Citing this family (452)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8036741B2 (en) 1996-04-30 2011-10-11 Medtronic, Inc. Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure
NL1004827C2 (en) * 1996-12-18 1998-06-19 Surgical Innovations Vof Device for the regulation of the circulatory system.
US6006134A (en) * 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US7749245B2 (en) 2000-01-27 2010-07-06 Medtronic, Inc. Cardiac valve procedure methods and devices
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US20070043435A1 (en) * 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
DE10010073B4 (en) 2000-02-28 2005-12-22 Ferrari, Markus, Dr.med. Dr.disc.pol. Anchor for implantable heart valve prostheses
USRE45130E1 (en) 2000-02-28 2014-09-09 Jenavalve Technology Gmbh Device for fastening and anchoring cardiac valve prostheses
ES2236204T3 (en) * 2000-03-03 2005-07-16 Cook Incorporated And bulbous valve stent for the treatment of vascular reflux.
EP1534180A4 (en) * 2002-08-08 2007-04-04 Neovasc Medical Ltd Geometric flow regulator
US8366769B2 (en) 2000-06-01 2013-02-05 Edwards Lifesciences Corporation Low-profile, pivotable heart valve sewing ring
EP1401358B1 (en) * 2000-06-30 2016-08-17 Medtronic, Inc. Apparatus for performing a procedure on a cardiac valve
US7544206B2 (en) 2001-06-29 2009-06-09 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
WO2002005888A1 (en) 2000-06-30 2002-01-24 Viacor Incorporated Intravascular filter with debris entrapment mechanism
US8623077B2 (en) 2001-06-29 2014-01-07 Medtronic, Inc. Apparatus for replacing a cardiac valve
US8771302B2 (en) 2001-06-29 2014-07-08 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US6409758B2 (en) 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
WO2002019951A1 (en) 2000-09-07 2002-03-14 Viacor, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US7097659B2 (en) * 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US7510572B2 (en) * 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
US8956407B2 (en) * 2000-09-20 2015-02-17 Mvrx, Inc. Methods for reshaping a heart valve annulus using a tensioning implant
US6893459B1 (en) * 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
US20090287179A1 (en) 2003-10-01 2009-11-19 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US7527646B2 (en) * 2000-09-20 2009-05-05 Ample Medical, Inc. Devices, systems, and methods for retaining a native heart valve leaflet
DE10050099A1 (en) * 2000-10-09 2002-04-18 Adiam Life Science Ag Tubular cardiac valve prosthesis has individual parts all made of polyurethane, forming an integrated component
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
US20040093075A1 (en) * 2000-12-15 2004-05-13 Titus Kuehne Stent with valve and method of use thereof
US6699274B2 (en) * 2001-01-22 2004-03-02 Scimed Life Systems, Inc. Stent delivery system and method of manufacturing same
US7374571B2 (en) 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
US20050055082A1 (en) 2001-10-04 2005-03-10 Shmuel Ben Muvhar Flow reducing implant
FR2828263B1 (en) 2001-08-03 2007-05-11 Philipp Bonhoeffer The implantation device of an implant and method of implantation of the device
US20030050648A1 (en) 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
CA2462254A1 (en) * 2001-10-01 2003-04-10 Am Discovery, Incorporated Devices for treating atrial fibrilation
WO2004030568A3 (en) 2002-10-01 2004-09-30 Ample Medical Inc Device and method for repairing a native heart valve leaflet
EP1562522B1 (en) * 2002-10-01 2008-12-31 Ample Medical, Inc. Devices and systems for reshaping a heart valve annulus
US6592594B2 (en) 2001-10-25 2003-07-15 Spiration, Inc. Bronchial obstruction device deployment system and method
US8308797B2 (en) * 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US20150351902A1 (en) * 2004-07-10 2015-12-10 Colibri Heart Valve Llc Percutaneously implantable replacement heart valve device and method of making same
US20030154988A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Intra-bronchial device that provides a medicant intra-bronchially to the patient
US6929637B2 (en) 2002-02-21 2005-08-16 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20030181922A1 (en) * 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
US20030195385A1 (en) * 2002-04-16 2003-10-16 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US20030216769A1 (en) 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US8348963B2 (en) * 2002-07-03 2013-01-08 Hlt, Inc. Leaflet reinforcement for regurgitant valves
US7578843B2 (en) 2002-07-16 2009-08-25 Medtronic, Inc. Heart valve prosthesis
US7959674B2 (en) 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
US6875231B2 (en) * 2002-09-11 2005-04-05 3F Therapeutics, Inc. Percutaneously deliverable heart valve
WO2004026183A3 (en) 2002-09-20 2005-01-13 Nellix Inc Stent-graft with positioning anchor
EP1551274B1 (en) * 2002-09-23 2014-12-24 Medtronic 3F Therapeutics, Inc. Prosthetic mitral valve
US20060188331A1 (en) * 2002-09-28 2006-08-24 Moore Orel R Extended life road system and method
US7416557B2 (en) 2002-10-24 2008-08-26 Boston Scientific Scimed, Inc. Venous valve apparatus and method
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
US6830585B1 (en) 2003-01-14 2004-12-14 3F Therapeutics, Inc. Percutaneously deliverable heart valve and methods of implantation
US7393339B2 (en) * 2003-02-21 2008-07-01 C. R. Bard, Inc. Multi-lumen catheter with separate distal tips
US20050084593A1 (en) * 2003-02-21 2005-04-21 Calvert Frederic R.Jr. Reduced fat and carbohydrate cultured dairy product and process for manufacturing such cultured dairy product
US8157810B2 (en) 2003-02-26 2012-04-17 Cook Medical Technologies Llc Prosthesis adapted for placement under external imaging
US7100616B2 (en) 2003-04-08 2006-09-05 Spiration, Inc. Bronchoscopic lung volume reduction method
US7175656B2 (en) * 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
WO2004093745A1 (en) * 2003-04-23 2004-11-04 Cook Incorporated Devices kits, and methods for placing multiple intraluminal medical devices in a body vessel
US6974476B2 (en) 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
WO2005002466A3 (en) 2003-07-08 2005-03-03 Ventor Technologies Ltd Implantable prosthetic devices particularly for transarterial delivery in the treatment of aortic stenosis, and methods of implanting such devices
US7201772B2 (en) * 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
WO2005011534A1 (en) * 2003-07-31 2005-02-10 Cook Incorporated Prosthetic valve devices and methods of making such devices
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20050075720A1 (en) * 2003-10-06 2005-04-07 Nguyen Tuoc Tan Minimally invasive valve replacement system
US20060259137A1 (en) * 2003-10-06 2006-11-16 Jason Artof Minimally invasive valve replacement system
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
CA2930497A1 (en) 2003-11-19 2005-06-02 Neovasc Medical Ltd. Vascular implant
US7186265B2 (en) * 2003-12-10 2007-03-06 Medtronic, Inc. Prosthetic cardiac valves and systems and methods for implanting thereof
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US8128681B2 (en) * 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7261732B2 (en) 2003-12-22 2007-08-28 Henri Justino Stent mounted valve
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
ES2457747T3 (en) 2003-12-23 2014-04-29 Sadra Medical, Inc. Replaceable heart valve
US20050137687A1 (en) * 2003-12-23 2005-06-23 Sadra Medical Heart valve anchor and method
US7824442B2 (en) * 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US20050137696A1 (en) * 2003-12-23 2005-06-23 Sadra Medical Apparatus and methods for protecting against embolization during endovascular heart valve replacement
US20050137064A1 (en) * 2003-12-23 2005-06-23 Stephen Nothnagle Hand weights with finger support
US20050137691A1 (en) * 2003-12-23 2005-06-23 Sadra Medical Two piece heart valve and anchor
US7748389B2 (en) * 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
US7470285B2 (en) 2004-02-05 2008-12-30 Children's Medical Center Corp. Transcatheter delivery of a replacement heart valve
US8337545B2 (en) 2004-02-09 2012-12-25 Cook Medical Technologies Llc Woven implantable device
CA2557657C (en) 2004-02-27 2013-06-18 Aortx, Inc. Prosthetic heart valve delivery systems and methods
JP2007535342A (en) 2004-03-11 2007-12-06 パーキュテイニアス カルディオバスキュラー ソリューションズ ピー・ティー・ワイ リミテッド Percutaneous prosthetic heart valve
WO2005087139A1 (en) * 2004-03-15 2005-09-22 Baker Medical Research Institute Treating valve failure
US20050228494A1 (en) * 2004-03-29 2005-10-13 Salvador Marquez Controlled separation heart valve frame
EP1729685B1 (en) * 2004-03-31 2015-07-15 Cook Medical Technologies LLC Endoluminal graft with a prosthetic valve
WO2005096988A1 (en) 2004-04-01 2005-10-20 Cook Incorporated A device for retracting the walls of a body vessel with remodelable material
US7641686B2 (en) * 2004-04-23 2010-01-05 Direct Flow Medical, Inc. Percutaneous heart valve with stentless support
WO2005102015A3 (en) 2004-04-23 2007-04-19 3F Therapeutics Inc Implantable prosthetic valve
EP2422751A3 (en) * 2004-05-05 2013-01-02 Direct Flow Medical, Inc. Unstented heart valve with formed in place support structure
US7717951B2 (en) * 2004-05-06 2010-05-18 Cook Incorporated Delivery system that facilitates visual inspection of an intraluminal medical device
US20060122693A1 (en) * 2004-05-10 2006-06-08 Youssef Biadillah Stent valve and method of manufacturing same
US20060122692A1 (en) * 2004-05-10 2006-06-08 Ran Gilad Stent valve and method of using same
US20060122686A1 (en) * 2004-05-10 2006-06-08 Ran Gilad Stent and method of manufacturing same
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
EP2982337A1 (en) 2004-06-30 2016-02-10 Edwards Lifesciences PVT, Inc. Paravalvular leak detection, sealing, and prevention
EP1781179A1 (en) * 2004-07-06 2007-05-09 Baker Medical Research Institute Treating valvular insufficiency
US8048145B2 (en) 2004-07-22 2011-11-01 Endologix, Inc. Graft systems having filling structures supported by scaffolds and methods for their use
WO2006026371A1 (en) * 2004-08-27 2006-03-09 Cook Incorporated Placement of multiple intraluminal medical devices within a body vessel
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
CN101056596B (en) 2004-09-14 2011-08-03 爱德华兹生命科学股份公司 Device and method for treatment of heart valve regurgitation
WO2006034436A3 (en) 2004-09-21 2006-10-19 Stout Medical Group Lp Expandable support device and method of use
US6951571B1 (en) 2004-09-30 2005-10-04 Rohit Srivastava Valve implanting device
CA3005526A1 (en) * 2004-10-02 2006-04-20 Edwards Lifesciences Cardiaq, Llc Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
US7331010B2 (en) * 2004-10-29 2008-02-12 International Business Machines Corporation System, method and storage medium for providing fault detection and correction in a memory subsystem
KR20070094888A (en) * 2004-11-19 2007-09-27 메드트로닉 인코포레이티드 Method and apparatus for treatment of cardiac valves
US7766973B2 (en) * 2005-01-19 2010-08-03 Gi Dynamics, Inc. Eversion resistant sleeves
DE102005003632A1 (en) 2005-01-20 2006-08-17 Ferrari, Markus, Dr.med. Dr.disc.pol. Catheter for trans-vascular implantation of prosthetic heart valves
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
US7878966B2 (en) 2005-02-04 2011-02-01 Boston Scientific Scimed, Inc. Ventricular assist and support device
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8574257B2 (en) 2005-02-10 2013-11-05 Edwards Lifesciences Corporation System, device, and method for providing access in a cardiovascular environment
DK1850796T3 (en) * 2005-02-18 2016-01-18 Cleveland Clinic Foundation Apparatus for replacement of a heart valve
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7780724B2 (en) * 2006-02-24 2010-08-24 California Institute Of Technology Monolithic in situ forming valve system
US7331991B2 (en) 2005-02-25 2008-02-19 California Institute Of Technology Implantable small percutaneous valve and methods of delivery
US20080275550A1 (en) * 2006-02-24 2008-11-06 Arash Kheradvar Implantable small percutaneous valve and methods of delivery
US20060195186A1 (en) * 2005-02-28 2006-08-31 Drews Michael J Connectors for two piece heart valves and methods for implanting such heart valves
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US20060259128A1 (en) * 2005-04-18 2006-11-16 Cook Incorporated Method for implanting prosthetic valves
EP1893131A1 (en) * 2005-04-20 2008-03-05 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
US7833268B2 (en) * 2005-04-29 2010-11-16 Delgado Iii Reynolds M Method and apparatus for implanting an aortic valve prosthesis
EP2901967A1 (en) 2005-05-24 2015-08-05 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US7708775B2 (en) * 2005-05-24 2010-05-04 Edwards Lifesciences Corporation Methods for rapid deployment of prosthetic heart valves
US9955969B2 (en) * 2005-05-26 2018-05-01 Texas Heart Institute Surgical system and method for attaching a prosthetic vessel to a hollow structure
WO2006128193A3 (en) * 2005-05-27 2007-11-22 Heart Leaflet Technologies Inc Stentless support structure
WO2006130505A3 (en) 2005-05-27 2007-06-28 Arbor Surgical Technologies Gasket with collar for prosthetic heart valves and methods for using them
CA2610669A1 (en) 2005-06-07 2006-12-14 Direct Flow Medical, Inc. Stentless aortic valve replacement with high radial strength
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US20060287668A1 (en) * 2005-06-16 2006-12-21 Fawzi Natalie V Apparatus and methods for intravascular embolic protection
WO2007008600A3 (en) 2005-07-07 2008-01-17 Nellix Inc Systems and methods for endovascular aneurysm treatment
US7776084B2 (en) 2005-07-13 2010-08-17 Edwards Lifesciences Corporation Prosthetic mitral heart valve having a contoured sewing ring
WO2007009107A3 (en) 2005-07-14 2008-08-07 Scott E Greenhalgh Expandable support device and method of use
WO2007013999A3 (en) * 2005-07-21 2007-07-05 Florida Internat University Collapsible heart valve with polymer leaflets
US8790396B2 (en) * 2005-07-27 2014-07-29 Medtronic 3F Therapeutics, Inc. Methods and systems for cardiac valve delivery
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
US20080188928A1 (en) * 2005-09-16 2008-08-07 Amr Salahieh Medical device delivery sheath
US7569071B2 (en) * 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US7785366B2 (en) * 2005-10-26 2010-08-31 Maurer Christopher W Mitral spacer
US8092525B2 (en) 2005-10-26 2012-01-10 Cardiosolutions, Inc. Heart valve implant
US8449606B2 (en) 2005-10-26 2013-05-28 Cardiosolutions, Inc. Balloon mitral spacer
US8778017B2 (en) 2005-10-26 2014-07-15 Cardiosolutions, Inc. Safety for mitral valve implant
US8216302B2 (en) * 2005-10-26 2012-07-10 Cardiosolutions, Inc. Implant delivery and deployment system and method
DE102005051849B4 (en) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington A device for implantation and fixation of prosthetic heart valves
DE102005052628B4 (en) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Self-expanding, flexible wire mesh with integrated valve prosthesis for the transvascular cardiac valve replacement and a system comprising such a device and a delivery catheter
US7917213B2 (en) 2005-11-04 2011-03-29 Kenergy, Inc. MRI compatible implanted electronic medical lead
US8092520B2 (en) * 2005-11-10 2012-01-10 CardiAQ Technologies, Inc. Vascular prosthesis connecting stent
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US8764820B2 (en) * 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US20070150041A1 (en) * 2005-12-22 2007-06-28 Nellix, Inc. Methods and systems for aneurysm treatment using filling structures
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
US8403981B2 (en) 2006-02-27 2013-03-26 CardiacMC, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8147541B2 (en) 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
WO2007106755A1 (en) * 2006-03-10 2007-09-20 Arbor Surgical Technologies, Inc. Valve introducers and methods for making and using them
US7691151B2 (en) * 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US7740655B2 (en) 2006-04-06 2010-06-22 Medtronic Vascular, Inc. Reinforced surgical conduit for implantation of a stented valve therein
US7524331B2 (en) * 2006-04-06 2009-04-28 Medtronic Vascular, Inc. Catheter delivered valve having a barrier to provide an enhanced seal
US20070239254A1 (en) * 2006-04-07 2007-10-11 Chris Chia System for percutaneous delivery and removal of a prosthetic valve
US20070239269A1 (en) * 2006-04-07 2007-10-11 Medtronic Vascular, Inc. Stented Valve Having Dull Struts
EP2004101A2 (en) * 2006-04-07 2008-12-24 Penumbra, Inc. Aneurysm occlusion system and method
US7727276B2 (en) * 2006-04-14 2010-06-01 Machiraju Venkat R System and method for heart valve replacement
US20070244544A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US20070244545A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Prosthetic Conduit With Radiopaque Symmetry Indicators
US20070244546A1 (en) * 2006-04-18 2007-10-18 Medtronic Vascular, Inc. Stent Foundation for Placement of a Stented Valve
US8021161B2 (en) 2006-05-01 2011-09-20 Edwards Lifesciences Corporation Simulated heart valve root for training and testing
US8070800B2 (en) 2006-05-05 2011-12-06 Children's Medical Center Corporation Transcatheter heart valve prostheses
US8585594B2 (en) 2006-05-24 2013-11-19 Phoenix Biomedical, Inc. Methods of assessing inner surfaces of body lumens or organs
US7811316B2 (en) 2006-05-25 2010-10-12 Deep Vein Medical, Inc. Device for regulating blood flow
US8092517B2 (en) * 2006-05-25 2012-01-10 Deep Vein Medical, Inc. Device for regulating blood flow
WO2007142935B1 (en) 2006-05-30 2008-02-14 Cook Inc Artificial valve prosthesis
CN101484093B (en) 2006-06-01 2011-09-07 爱德华兹生命科学公司 Prosthetic insert for improving heart valve function
US8376865B2 (en) 2006-06-20 2013-02-19 Cardiacmd, Inc. Torque shaft and torque shaft drive
EP2298243A1 (en) 2006-06-20 2011-03-23 AorTx, Inc. Prosthetic heart valves, support structures and systems and methods for implanting the same
US8142492B2 (en) 2006-06-21 2012-03-27 Aortx, Inc. Prosthetic valve implantation systems
RU2325873C2 (en) * 2006-07-20 2008-06-10 Александр Васильевич Самков Artificial cardiac valve cusp and methods of its producing
WO2008013915A9 (en) * 2006-07-28 2008-08-21 Arshad Quadri Percutaneous valve prosthesis and system and method for implanting same
CN102247223B (en) * 2006-09-08 2015-05-06 爱德华兹生命科学公司 Integrated heart valve delivery system
CN101662999B (en) * 2006-09-28 2016-01-20 心叶科技公司 Transdermal delivery transfer means for prosthesis
US8029556B2 (en) 2006-10-04 2011-10-04 Edwards Lifesciences Corporation Method and apparatus for reshaping a ventricle
EP2083901B1 (en) 2006-10-16 2017-12-27 Medtronic Ventor Technologies Ltd. Transapical delivery system with ventriculo-arterial overflow bypass
US7935144B2 (en) 2006-10-19 2011-05-03 Direct Flow Medical, Inc. Profile reduction of valve implant
US8133213B2 (en) 2006-10-19 2012-03-13 Direct Flow Medical, Inc. Catheter guidance through a calcified aortic valve
US20090248143A1 (en) * 2006-10-24 2009-10-01 Beth Israel Deaconess Medical Center Percutaneous aortic valve assembly
CA2671754C (en) 2006-12-06 2015-08-18 Medtronic Corevalve Llc System and method for transapical delivery of an annulus anchored self-expanding valve
CN101605509B (en) * 2006-12-15 2012-09-19 生物传感器国际集团有限公司 Stent systems
WO2008091493A1 (en) 2007-01-08 2008-07-31 California Institute Of Technology In-situ formation of a valve
ES2441801T3 (en) * 2007-02-05 2014-02-06 Boston Scientific Limited Percutaneous valve and delivery system
US20080262593A1 (en) * 2007-02-15 2008-10-23 Ryan Timothy R Multi-layered stents and methods of implanting
US20080208327A1 (en) * 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
EP3150171A1 (en) 2007-05-15 2017-04-05 JenaValve Technology, Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandalbe heart valve stent
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
FR2915087A1 (en) 2007-04-20 2008-10-24 Corevalve Inc Implant treatment of a heart valve, particularly a mitral valve implant inculant material and equipment for setting up of this implant.
US8011277B2 (en) 2007-05-10 2011-09-06 Wagic, Inc. Hand tool with multiple bit storage and a method for using the same
US8663318B2 (en) 2007-07-23 2014-03-04 Hocor Cardiovascular Technologies Llc Method and apparatus for percutaneous aortic valve replacement
US8663319B2 (en) 2007-07-23 2014-03-04 Hocor Cardiovascular Technologies Llc Methods and apparatus for percutaneous aortic valve replacement
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US8747458B2 (en) 2007-08-20 2014-06-10 Medtronic Ventor Technologies Ltd. Stent loading tool and method for use thereof
ES2632485T3 (en) 2007-08-21 2017-09-13 Symetis Sa A replacement valve
CA2697364C (en) 2007-08-23 2017-10-17 Direct Flow Medical, Inc. Translumenally implantable heart valve with formed in place support
US20090138079A1 (en) * 2007-10-10 2009-05-28 Vector Technologies Ltd. Prosthetic heart valve for transfemoral delivery
CN101868199B (en) 2007-10-12 2016-04-06 斯波瑞申有限公司 Valve loader methods, systems, and devices
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US7981151B2 (en) * 2007-10-15 2011-07-19 Edwards Lifesciences Corporation Transcatheter heart valve with micro-anchors
CA2703665C (en) 2007-10-25 2016-05-10 Symetis Sa Stents, valved-stents and methods and systems for delivery thereof
US8715337B2 (en) * 2007-11-09 2014-05-06 Cook Medical Technologies Llc Aortic valve stent graft
US8852270B2 (en) 2007-11-15 2014-10-07 Cardiosolutions, Inc. Implant delivery system and method
US8597347B2 (en) * 2007-11-15 2013-12-03 Cardiosolutions, Inc. Heart regurgitation method and apparatus
US7846199B2 (en) 2007-11-19 2010-12-07 Cook Incorporated Remodelable prosthetic valve
US8876897B2 (en) * 2007-12-20 2014-11-04 Arash Kheradvar Implantable prosthetic valves and methods relating to same
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8499667B2 (en) 2008-01-17 2013-08-06 WAGIC, Inc Tool holder
US8468916B2 (en) 2008-01-17 2013-06-25 Wagic, Inc. Biaxial foldout tool with multiple tools on a side and a rotational stop
US7946203B2 (en) 2008-01-17 2011-05-24 Wagic, Inc. Tool handle for holding multiple tools of different sizes during use
US8033200B2 (en) 2008-01-17 2011-10-11 Wagic, Inc. Universal ratcheting tool
USD708036S1 (en) 2008-01-17 2014-07-01 Wagic, Inc. Biaxial foldout tool
US8925429B2 (en) 2008-01-17 2015-01-06 Wagic, Inc. Radial foldout tool
US9393115B2 (en) 2008-01-24 2016-07-19 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
CA2714062A1 (en) 2008-01-24 2009-07-30 Medtronic, Inc. Stents for prosthetic heart valves
US20090287290A1 (en) * 2008-01-24 2009-11-19 Medtronic, Inc. Delivery Systems and Methods of Implantation for Prosthetic Heart Valves
US9149358B2 (en) 2008-01-24 2015-10-06 Medtronic, Inc. Delivery systems for prosthetic heart valves
US20100145435A1 (en) * 2008-02-21 2010-06-10 Valerian Voinov Implantable prosthetic valve stent
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US20090264989A1 (en) * 2008-02-28 2009-10-22 Philipp Bonhoeffer Prosthetic heart valve systems
EP2247264A4 (en) * 2008-02-29 2011-08-31 Florida Int Univ Board Trustees Catheter deliverable artificial multi-leaflet heart valve prosthesis and intravascular delivery system for a catheter deliverable heart valve prosthesis
US8696689B2 (en) * 2008-03-18 2014-04-15 Medtronic Ventor Technologies Ltd. Medical suturing device and method for use thereof
US8430927B2 (en) 2008-04-08 2013-04-30 Medtronic, Inc. Multiple orifice implantable heart valve and methods of implantation
US20090264820A1 (en) * 2008-04-16 2009-10-22 Abiomed, Inc. Method and apparatus for implanting an endoluminal prosthesis such as a prosthetic valve
WO2009132187A1 (en) 2008-04-23 2009-10-29 Medtronic, Inc. Stented heart valve devices
EP3141219A1 (en) 2008-04-23 2017-03-15 Medtronic, Inc. Stented heart valve devices
WO2009132309A1 (en) 2008-04-25 2009-10-29 Nellix, Inc. Stent graft delivery system
US20090276040A1 (en) * 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US8728153B2 (en) 2008-05-14 2014-05-20 Onset Medical Corporation Expandable transapical sheath and method of use
US9440054B2 (en) 2008-05-14 2016-09-13 Onset Medical Corporation Expandable transapical sheath and method of use
WO2009149294A1 (en) 2008-06-04 2009-12-10 Nellix, Inc. Sealing apparatus and methods of use
US9259317B2 (en) * 2008-06-13 2016-02-16 Cardiosolutions, Inc. System and method for implanting a heart implant
US8591460B2 (en) 2008-06-13 2013-11-26 Cardiosolutions, Inc. Steerable catheter and dilator and system and method for implanting a heart implant
US8998981B2 (en) 2008-09-15 2015-04-07 Medtronic, Inc. Prosthetic heart valve having identifiers for aiding in radiographic positioning
WO2010033931A3 (en) * 2008-09-19 2010-06-03 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
US9314335B2 (en) 2008-09-19 2016-04-19 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
US8287591B2 (en) * 2008-09-19 2012-10-16 Edwards Lifesciences Corporation Transformable annuloplasty ring configured to receive a percutaneous prosthetic heart valve implantation
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
JP2012504031A (en) 2008-09-29 2012-02-16 カルディアック バルブ テクノロジーズ,インコーポレーテッド Heart valves
WO2010040009A1 (en) 2008-10-01 2010-04-08 Cardiaq Valve Technologies, Inc. Delivery system for vascular implant
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
WO2010065265A3 (en) 2008-11-25 2010-09-30 Edwards Lifesciences Corporation Apparatus and method for in situ expansion of prosthetic device
US9005139B2 (en) * 2008-12-15 2015-04-14 Assis Medical Ltd. Device, system and method for sizing of tissue openings
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
US20100210899A1 (en) * 2009-01-21 2010-08-19 Tendyne Medical, Inc. Method for percutaneous lateral access to the left ventricle for treatment of mitral insufficiency by papillary muscle alignment
US20110015476A1 (en) * 2009-03-04 2011-01-20 Jeff Franco Devices and Methods for Treating Cardiomyopathy
US8021420B2 (en) * 2009-03-12 2011-09-20 Medtronic Vascular, Inc. Prosthetic valve delivery system
US9078751B2 (en) * 2009-03-17 2015-07-14 Mitrassist Medical Ltd. Heart valve prosthesis with collapsible valve and method of delivery thereof
CN101919752B (en) 2009-03-30 2014-04-09 苏州杰成医疗科技有限公司 Valve prosthesis with movably attached claspers with apex
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
EP2419050B1 (en) * 2009-04-15 2017-06-28 Edwards Lifesciences CardiAQ LLC Vascular implant and delivery system
US8500801B2 (en) 2009-04-21 2013-08-06 Medtronic, Inc. Stents for prosthetic heart valves and methods of making same
US9011524B2 (en) * 2009-04-24 2015-04-21 Medtronic, Inc. Prosthetic heart valves and methods of attaching same
CA2760461C (en) * 2009-04-29 2014-10-07 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
US9579103B2 (en) 2009-05-01 2017-02-28 Endologix, Inc. Percutaneous method and device to treat dissections
US8468667B2 (en) 2009-05-15 2013-06-25 Jenavalve Technology, Inc. Device for compressing a stent
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
ES2653948T3 (en) 2009-07-14 2018-02-09 Edwards Lifesciences Corporation System transapical heart valve placement
US8845722B2 (en) * 2009-08-03 2014-09-30 Shlomo Gabbay Heart valve prosthesis and method of implantation thereof
US9120208B2 (en) 2009-10-05 2015-09-01 WAGIC, Inc Handled ratcheting tool with a flip out handle
US8621963B2 (en) 2009-10-05 2014-01-07 Wagic, Inc. Dual purpose flip-out and T handle
US8449625B2 (en) 2009-10-27 2013-05-28 Edwards Lifesciences Corporation Methods of measuring heart valve annuluses for valve replacement
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
WO2011109450A3 (en) 2010-03-01 2012-01-05 Colibri Heart Valve Llc Percutaneously deliverable heart valve and methods associated therewith
EP3335670A1 (en) * 2010-03-05 2018-06-20 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US20110224785A1 (en) * 2010-03-10 2011-09-15 Hacohen Gil Prosthetic mitral valve with tissue anchors
CA2794121C (en) 2010-03-23 2016-10-11 Edwards Lifesciences Corporation Methods of conditioning sheet bioprosthetic tissue
US8992599B2 (en) * 2010-03-26 2015-03-31 Thubrikar Aortic Valve, Inc. Valve component, frame component and prosthetic valve device including the same for implantation in a body lumen
US20110257721A1 (en) * 2010-04-15 2011-10-20 Medtronic, Inc. Prosthetic Heart Valves and Delivery Methods
US8568474B2 (en) * 2010-04-26 2013-10-29 Medtronic, Inc. Transcatheter prosthetic heart valve post-dilatation remodeling devices and methods
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
WO2011143238A3 (en) 2010-05-10 2012-03-29 Edwards Lifesciences Corporation Prosthetic heart valve
WO2011143263A3 (en) 2010-05-10 2013-01-24 Heart Leaflet Technologies, Inc. Stentless support structure
US9554901B2 (en) 2010-05-12 2017-01-31 Edwards Lifesciences Corporation Low gradient prosthetic heart valve
US8535380B2 (en) 2010-05-13 2013-09-17 Stout Medical Group, L.P. Fixation device and method
US9603708B2 (en) 2010-05-19 2017-03-28 Dfm, Llc Low crossing profile delivery catheter for cardiovascular prosthetic implant
US20110288626A1 (en) 2010-05-20 2011-11-24 Helmut Straubinger Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
CN103002833B (en) 2010-05-25 2016-05-11 耶拿阀门科技公司 Artificial heart valve and includes an artificial heart valve and the stent delivery catheter endoprosthesis
EP2585157A4 (en) 2010-06-28 2017-02-08 Colibri Heart Valve LLC Method and apparatus for the endoluminal delivery of intravascular devices
US9326852B2 (en) 2010-07-08 2016-05-03 Benjamin Spenser Method for implanting prosthetic valve
US8408214B2 (en) 2010-07-08 2013-04-02 Benjamin Spenser Method for implanting prosthetic valve
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
EP2600798B1 (en) * 2010-08-03 2015-10-28 Cook Medical Technologies LLC Two valve caval stent for functional replacement of incompetent tricuspid valve
EP2608747A4 (en) 2010-08-24 2015-02-11 Flexmedex Llc Support device and method for use
EP2611388A2 (en) 2010-09-01 2013-07-10 Medtronic Vascular Galway Limited Prosthetic valve support structure
JP5970458B2 (en) 2010-09-01 2016-08-17 ムバルブ・テクノロジーズ・リミテッド Heart valve support structure
US9125741B2 (en) 2010-09-10 2015-09-08 Edwards Lifesciences Corporation Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
US9370418B2 (en) 2010-09-10 2016-06-21 Edwards Lifesciences Corporation Rapidly deployable surgical heart valves
US9579193B2 (en) 2010-09-23 2017-02-28 Transmural Systems Llc Methods and systems for delivering prostheses using rail techniques
EP3001978A1 (en) 2010-09-23 2016-04-06 CardiAQ Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
US9149286B1 (en) 2010-11-12 2015-10-06 Flexmedex, LLC Guidance tool and method for use
WO2012068298A1 (en) 2010-11-17 2012-05-24 Endologix, Inc. Devices and methods to treat vascular dissections
US9226824B2 (en) 2010-11-30 2016-01-05 Edwards Lifesciences Corporation Surgical stabilizer and closure system
US9737400B2 (en) 2010-12-14 2017-08-22 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
CN103491900B (en) 2010-12-23 2017-03-01 托尔福公司 For mitral valve repair and replacement of system
US8801768B2 (en) 2011-01-21 2014-08-12 Endologix, Inc. Graft systems having semi-permeable filling structures and methods for their use
US8888843B2 (en) 2011-01-28 2014-11-18 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
US8932343B2 (en) 2011-02-01 2015-01-13 St. Jude Medical, Cardiology Division, Inc. Blunt ended stent for prosthetic heart valve
JP5575277B2 (en) * 2011-02-18 2014-08-20 株式会社パイオラックスメディカルデバイス Abdominal cavity - venous shunt stent
WO2012127309A4 (en) 2011-03-21 2013-01-31 Montorfano Matteo Disk-based valve apparatus and method for the treatment of valve dysfunction
US9055937B2 (en) 2011-04-01 2015-06-16 Edwards Lifesciences Corporation Apical puncture access and closure system
EP2693980A1 (en) 2011-04-06 2014-02-12 Endologix, Inc. Method and system for endovascular aneurysm treatment
US9381082B2 (en) 2011-04-22 2016-07-05 Edwards Lifesciences Corporation Devices, systems and methods for accurate positioning of a prosthetic valve
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
US20120316599A1 (en) * 2011-06-08 2012-12-13 Ghassan Kassab Thrombus removal systems and devices and methods of using the same
CN107647939A (en) 2011-06-21 2018-02-02 托尔福公司 Prosthetic heart valve devices and associated systems and methods
US8795357B2 (en) 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
KR20140049566A (en) * 2011-07-25 2014-04-25 아클라런트, 인코포레이션 Devices and methods for transnasal dilation and irrigation of the sinuses
WO2013016094A3 (en) * 2011-07-28 2013-03-21 Acclarent, Inc. Improved device and method for dilating an airway stenosis
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2013021374A3 (en) * 2011-08-05 2013-06-06 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US9968445B2 (en) * 2013-06-14 2018-05-15 The Regents Of The University Of California Transcatheter mitral valve
US9480559B2 (en) 2011-08-11 2016-11-01 Tendyne Holdings, Inc. Prosthetic valves and related inventions
EP2747682A4 (en) 2011-08-23 2015-01-21 Flexmedex Llc Tissue removal device and method
EP2747709A4 (en) * 2011-09-09 2015-04-15 Univ Emory Systems, devices and methods for repair of heart valve lesions
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
EP2750631A1 (en) 2011-10-19 2014-07-09 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
JP6005168B2 (en) 2011-10-21 2016-10-12 イエナバルブ テクノロジー インク Insertion system and heart valve defects therapeutic medical device comprising expandable heart valve stent introducer catheter system into a patient's body, the catheter system
WO2013067194A3 (en) * 2011-11-01 2013-07-11 Stinis Curtiss T Aortic valve positioning systems, devices, and methods
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
US8940014B2 (en) 2011-11-15 2015-01-27 Boston Scientific Scimed, Inc. Bond between components of a medical device
US9480558B2 (en) 2011-12-05 2016-11-01 Medtronic, Inc. Transcatheter valve having reduced seam exposure
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
JP6179949B2 (en) * 2012-01-30 2017-08-16 川澄化学工業株式会社 Biliary stent
CA2863503A1 (en) * 2012-02-01 2013-08-08 Hlt, Inc. Invertible tissue valve and method
WO2013128432A1 (en) 2012-02-28 2013-09-06 Mvalve Technologies Ltd. Cardiac valve support structure
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
EP2822506A4 (en) * 2012-03-05 2015-10-28 Univ Pennsylvania Superabsorbent coated stents for vascular reduction and for anchoring valve replacements
EP2641569B1 (en) 2012-03-23 2015-01-28 Sorin Group Italia S.r.l. A collapsible valve prosthesis
WO2013150512A1 (en) 2012-04-05 2013-10-10 Mvalve Technologies Ltd. Cardiac valve support structure
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
US9445897B2 (en) 2012-05-01 2016-09-20 Direct Flow Medical, Inc. Prosthetic implant delivery device with introducer catheter
US9387579B2 (en) 2012-05-15 2016-07-12 Wagic, Inc. Adjustable tool handle for holding a tool during use
US9193058B2 (en) 2012-05-15 2015-11-24 Wagic, Inc. Adjustable tool handle for holding a tool during use
WO2013171007A1 (en) 2012-05-16 2013-11-21 Jenavalve Technology Gmbh Catheter delivery system for introducing an expandable heart valve prosthesis and medical device for the treatment of a heart valve defect
US9345573B2 (en) * 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9526610B2 (en) * 2012-06-12 2016-12-27 Medtronic, Inc. Method and device for percutaneous valve annuloplasty
US20140005776A1 (en) 2012-06-29 2014-01-02 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
US9283072B2 (en) * 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
WO2014022124A1 (en) 2012-07-28 2014-02-06 Tendyne Holdings, Inc. Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly
WO2014021905A1 (en) 2012-07-30 2014-02-06 Tendyne Holdings, Inc. Improved delivery systems and methods for transcatheter prosthetic valves
EP2695586A1 (en) 2012-08-10 2014-02-12 Sorin Group Italia S.r.l. A valve prosthesis and kit
US8628571B1 (en) 2012-11-13 2014-01-14 Mitraltech Ltd. Percutaneously-deliverable mechanical valve
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
US10039638B2 (en) 2012-12-19 2018-08-07 W. L. Gore & Associates, Inc. Geometric prosthetic heart valves
EP3375411A1 (en) 2012-12-31 2018-09-19 Edwards Lifesciences Corporation Surgical heart valves adapted for post-implant expansion
US9132007B2 (en) 2013-01-10 2015-09-15 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage components for a transcatheter valve prosthesis
EP2948103A2 (en) 2013-01-24 2015-12-02 Mitraltech Ltd. Ventricularly-anchored prosthetic valves
US9675451B2 (en) 2013-02-01 2017-06-13 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
JP6205436B2 (en) * 2013-03-01 2017-09-27 コーマトリックス カーディオバスキュラー, インコーポレイテッドCorMatrix Cardiovascular, Inc. Cardiovascular valve that is anchored
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
WO2014159093A1 (en) 2013-03-14 2014-10-02 Endologix, Inc. Method for forming materials in situ within a medical device
US9289297B2 (en) 2013-03-15 2016-03-22 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
US9232998B2 (en) 2013-03-15 2016-01-12 Cardiosolutions Inc. Trans-apical implant systems, implants and methods
US9193062B2 (en) 2013-03-15 2015-11-24 Wagic, Inc. Post lock tool holder for L-shaped wrenches
USD723276S1 (en) 2013-03-15 2015-03-03 Wagic, Inc. Post lock tool holder for L-shaped wrenches
CN105208973B (en) 2013-03-15 2018-04-03 Hlt股份有限公司 The low-profile prosthetic valve structure
EP2967945A4 (en) 2013-03-15 2016-11-09 California Inst Of Techn Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
EP2967863B1 (en) 2013-03-15 2018-01-31 Edwards Lifesciences Corporation Valved aortic conduits
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9907649B2 (en) * 2013-05-03 2018-03-06 Cormatrix Cardiovascular, Inc. Prosthetic tissue valves and methods for anchoring same to cardiovascular structures
US20160317292A1 (en) * 2013-05-03 2016-11-03 Cormatrix Cardiovascular, Inc. Prosthetic Tissue Valves
US9629718B2 (en) 2013-05-03 2017-04-25 Medtronic, Inc. Valve delivery tool
US20160317300A1 (en) * 2013-05-03 2016-11-03 Cormatrix Cardiovascular, Inc. Prosthetic Tissue Valves
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US9468527B2 (en) 2013-06-12 2016-10-18 Edwards Lifesciences Corporation Cardiac implant with integrated suture fasteners
KR20160041040A (en) 2013-06-14 2016-04-15 카디오솔루션즈, 인코포레이티드 Mitral valve spacer and system and method for implanting the same
EP3010448A4 (en) * 2013-06-17 2017-03-01 Heldman, Alan Prosthetic heart valve with linking element and methods for implanting same
WO2014203078A3 (en) * 2013-06-20 2015-05-21 Anagnostopoulos Constantinos Intra-aortic balloon apparatus, assist devices and methods for improving flow, counterpulsation and haemodynamics
CN105658178B (en) 2013-06-25 2018-05-08 坦迪尼控股股份有限公司 Thrombosis and structures for managing the prosthetic heart valve compliant feature
WO2014210299A1 (en) 2013-06-27 2014-12-31 Bridges Charles R Device, system, and method for implanting a prosthetic heart valve
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
WO2015013666A8 (en) 2013-07-26 2015-03-19 Cardiaq Valve Technologies, Inc. Systems and methods for sealing openings in an anatomical wall
US9919137B2 (en) 2013-08-28 2018-03-20 Edwards Lifesciences Corporation Integrated balloon catheter inflation system
CN105491978A (en) 2013-08-30 2016-04-13 耶拿阀门科技股份有限公司 Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US9050188B2 (en) 2013-10-23 2015-06-09 Caisson Interventional, LLC Methods and systems for heart valve therapy
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
WO2015092554A3 (en) * 2013-12-03 2015-12-03 Mark Lynn Jenson Transcatheter mitral valve replacement apparatus
US9393111B2 (en) 2014-01-15 2016-07-19 Sino Medical Sciences Technology Inc. Device and method for mitral valve regurgitation treatment
US9820852B2 (en) 2014-01-24 2017-11-21 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
US9072604B1 (en) * 2014-02-11 2015-07-07 Gilberto Melnick Modular transcatheter heart valve and implantation method
WO2015127283A8 (en) 2014-02-21 2016-09-29 Edwards Lifesciences Cardiaq Llc Delivery device for controlled deployment of a replacement valve
USD755384S1 (en) 2014-03-05 2016-05-03 Edwards Lifesciences Cardiaq Llc Stent
US10064719B2 (en) * 2014-03-11 2018-09-04 Highlife Sas Transcatheter valve prosthesis
EP2918247A1 (en) * 2014-03-11 2015-09-16 Epygon Sasu A prosthetic valve and a delivery device
EP2921139A1 (en) * 2014-03-18 2015-09-23 Nvt Ag Heartvalve implant
US10045765B2 (en) 2014-03-27 2018-08-14 Transmural Systems Llc Devices and methods for closure of transvascular or transcameral access ports
US20170014115A1 (en) 2014-03-27 2017-01-19 Transmural Systems Llc Devices and methods for closure of transvascular or transcameral access ports
US9549816B2 (en) 2014-04-03 2017-01-24 Edwards Lifesciences Corporation Method for manufacturing high durability heart valve
EP2929860B1 (en) * 2014-04-07 2017-06-28 Nvt Ag Device for implantation in the heart of a mammal
US9585752B2 (en) 2014-04-30 2017-03-07 Edwards Lifesciences Corporation Holder and deployment system for surgical heart valves
EP3139865A4 (en) * 2014-05-07 2018-03-28 Baylor College of Medicine Artificial, flexible valves and methods of fabricating and serially expanding the same
WO2015175863A1 (en) 2014-05-16 2015-11-19 St. Jude Medical, Cardiology Division, Inc. Stent assembly for use in prosthetic heart valves
WO2015173794A1 (en) * 2014-05-16 2015-11-19 Benichou, Netanel Replacement heart valve
WO2015184138A1 (en) 2014-05-29 2015-12-03 Cardiaq Valve Technologies, Inc. Prosthesis, delivery device and methods of use
US9974647B2 (en) 2014-06-12 2018-05-22 Caisson Interventional, LLC Two stage anchor and mitral valve assembly
CA2914094A1 (en) 2014-06-20 2015-12-20 Edwards Lifesciences Corporation Surgical heart valves identifiable post-implant
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US20160158000A1 (en) 2014-12-09 2016-06-09 Juan F. Granada Replacement cardiac valves and methods of use and manufacture
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
US9629720B2 (en) 2015-05-04 2017-04-25 Jacques Seguin Apparatus and methods for treating cardiac valve regurgitation
US20170007397A1 (en) * 2015-07-09 2017-01-12 David Rizik Method and apparatus for practice of tavr employing an expandable mesh-like catheter
DE102015111783A1 (en) 2015-07-21 2017-01-26 Biotronik Ag Catheter system for locating and implanting a body part replacement
US10034747B2 (en) 2015-08-27 2018-07-31 Medtronic Vascular, Inc. Prosthetic valve system having a docking component and a prosthetic valve component
US10080653B2 (en) 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US20170156863A1 (en) * 2015-12-03 2017-06-08 Medtronic Vascular, Inc. Venous valve prostheses
US20170296262A1 (en) * 2016-04-13 2017-10-19 Biosense Webster (Israel) Ltd. Pulmonary-vein cork device with ablation guiding trench
US20180021129A1 (en) * 2016-07-21 2018-01-25 Edwards Lifesciences Corporation Replacement heart valve prosthesis
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001768A1 (en) * 1991-07-16 1993-02-04 Stevens John H Endovascular aortic valve replacement
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis

Family Cites Families (277)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3143742A (en) * 1963-03-19 1964-08-11 Surgitool Inc Prosthetic sutureless heart valve
GB1127325A (en) 1965-08-23 1968-09-18 Henry Berry Improved instrument for inserting artificial heart valves
US3587115A (en) * 1966-05-04 1971-06-28 Donald P Shiley Prosthetic sutureless heart valves and implant tools therefor
US3472230A (en) 1966-12-19 1969-10-14 Fogarty T J Umbrella catheter
US3548417A (en) * 1967-09-05 1970-12-22 Ronnie G Kischer Heart valve having a flexible wall which rotates between open and closed positions
GB1268484A (en) 1968-06-28 1972-03-29 Brian John Bellhouse Improvements relating to non-return valves particularly as prosthetics
US3671979A (en) * 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3714671A (en) * 1970-11-30 1973-02-06 Cutter Lab Tissue-type heart valve with a graft support ring or stent
US3755823A (en) 1971-04-23 1973-09-04 Hancock Laboratories Inc Flexible stent for heart valve
GB1402255A (en) 1971-09-24 1975-08-06 Smiths Industries Ltd Medical or surgical devices of the kind having an inflatable balloon
US4035849A (en) * 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
US3997923A (en) * 1975-04-28 1976-12-21 St. Jude Medical, Inc. Heart valve prosthesis and suturing assembly and method of implanting a heart valve prosthesis in a heart
US4297749A (en) 1977-04-25 1981-11-03 Albany International Corp. Heart valve prosthesis
CA1069652A (en) * 1976-01-09 1980-01-15 Alain F. Carpentier Supported bioprosthetic heart valve with compliant orifice ring
US4056854A (en) 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
DE2834203C3 (en) * 1978-08-04 1981-04-02 Karl 7298 Lossburg De Hehl
US4265694A (en) 1978-12-14 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making unitized three leaflet heart valve
US4222126A (en) * 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
US4574803A (en) * 1979-01-19 1986-03-11 Karl Storz Tissue cutter
GB2056023B (en) 1979-08-06 1983-08-10 Ross D N Bodnar E Stent for a cardiac valve
US4327736A (en) 1979-11-20 1982-05-04 Kanji Inoue Balloon catheter
US4373216A (en) 1980-10-27 1983-02-15 Hemex, Inc. Heart valves having edge-guided occluders
US4339831A (en) * 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4470157A (en) * 1981-04-27 1984-09-11 Love Jack W Tricuspid prosthetic tissue heart valve
US4345340A (en) * 1981-05-07 1982-08-24 Vascor, Inc. Stent for mitral/tricuspid heart valve
US4406022A (en) 1981-11-16 1983-09-27 Kathryn Roy Prosthetic valve means for cardiovascular surgery
DE3342798T (en) * 1982-04-30 1985-01-10
US4484579A (en) * 1982-07-19 1984-11-27 University Of Pittsburgh Commissurotomy catheter apparatus and method
EP0103546B1 (en) 1982-08-09 1988-05-04 Domenico Iorio Surgical instrument for implanting prosthetic heart valves or the like
US4680031A (en) * 1982-11-29 1987-07-14 Tascon Medical Technology Corporation Heart valve prosthesis
GB8300636D0 (en) 1983-01-11 1983-02-09 Black M M Heart valve replacements
US4535483A (en) 1983-01-17 1985-08-20 Hemex, Inc. Suture rings for heart valves
US4705516A (en) * 1983-04-20 1987-11-10 Barone Hector D Setting for a cardiac valve
US4612011A (en) * 1983-07-22 1986-09-16 Hans Kautzky Central occluder semi-biological heart valve
CA1238482A (en) 1983-07-25 1988-06-28 Gioacchino Bona Method and apparatus for manufacture of valve flaps for cardiac valve prostheses
US4585705A (en) 1983-11-09 1986-04-29 Dow Corning Corporation Hard organopolysiloxane release coating
GB8332715D0 (en) * 1983-12-08 1984-01-18 Bodnar E Bioprosthetic valve
US4787899A (en) 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US4629459A (en) * 1983-12-28 1986-12-16 Shiley Inc. Alternate stent covering for tissue valves
US4627436A (en) * 1984-03-01 1986-12-09 Innoventions Biomedical Inc. Angioplasty catheter and method for use thereof
CA1229701A (en) 1984-03-16 1987-12-01 Piero Arru Cardiac valve prosthesis with valve flaps of biological tissue
US4592340A (en) * 1984-05-02 1986-06-03 Boyles Paul W Artificial catheter means
US5007896A (en) * 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US4979939A (en) 1984-05-14 1990-12-25 Surgical Systems & Instruments, Inc. Atherectomy system with a guide wire
DE3426300C2 (en) 1984-07-17 1987-12-03 Doguhan Dr.Med. 2800 Bremen De Baykut
GB8424582D0 (en) 1984-09-28 1984-11-07 Univ Glasgow Heart valve prosthesis
DE3442088A1 (en) 1984-11-17 1986-05-28 Beiersdorf Ag Heart valve prosthesis
US4759758A (en) 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
DE3530262A1 (en) * 1985-08-22 1987-02-26 Siemens Ag Circuit arrangement for testing a passive bus network system (CSMA / CD access method)
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
DE3640745A1 (en) 1985-11-30 1987-06-04 Ernst Peter Prof Dr M Strecker Catheter for producing or extending connections to or between body cavities
US4692164A (en) * 1986-03-06 1987-09-08 Moskovskoe Vysshee Tekhnicheskoe Uchilische, Imeni N.E. Baumana Bioprosthetic heart valve, methods and device for preparation thereof
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
GB2189150B (en) 1986-04-21 1990-02-14 Medinvent Sa Prosthesis and process for its manufacture
US4790843A (en) * 1986-06-16 1988-12-13 Baxter Travenol Laboratories, Inc. Prosthetic heart valve assembly
US4883458A (en) 1987-02-24 1989-11-28 Surgical Systems & Instruments, Inc. Atherectomy system and method of using the same
US4777951A (en) 1986-09-19 1988-10-18 Mansfield Scientific, Inc. Procedure and catheter instrument for treating patients for aortic stenosis
US4762128A (en) * 1986-12-09 1988-08-09 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
US4878495A (en) 1987-05-15 1989-11-07 Joseph Grayzel Valvuloplasty device with satellite expansion means
US4796629A (en) * 1987-06-03 1989-01-10 Joseph Grayzel Stiffened dilation balloon catheter device
US4829990A (en) 1987-06-25 1989-05-16 Thueroff Joachim Implantable hydraulic penile erector
US4851001A (en) 1987-09-17 1989-07-25 Taheri Syde A Prosthetic valve for a blood vein and an associated method of implantation of the valve
US5159937A (en) * 1987-09-30 1992-11-03 Advanced Cardiovascular Systems, Inc. Steerable dilatation catheter
US5266073A (en) 1987-12-08 1993-11-30 Wall W Henry Angioplasty stent
US5368608A (en) * 1988-04-01 1994-11-29 University Of Michigan, The Board Of Regents Calcification-resistant materials and methods of making same through use of multivalent cations
US4909252A (en) * 1988-05-26 1990-03-20 The Regents Of The Univ. Of California Perfusion balloon catheter
US5032128A (en) 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
DE8815082U1 (en) 1988-11-29 1989-05-18 Biotronik Mess- Und Therapiegeraete Gmbh & Co Ingenieurbuero Berlin, 1000 Berlin, De
US4856516A (en) * 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US4966604A (en) 1989-01-23 1990-10-30 Interventional Technologies Inc. Expandable atherectomy cutter with flexibly bowed blades
US4994077A (en) * 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
US5609626A (en) 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
EP0474748B1 (en) 1989-05-31 1995-01-25 Baxter International Inc. Biological valvular prosthesis
US5047041A (en) * 1989-08-22 1991-09-10 Samuels Peter B Surgical apparatus for the excision of vein valves in situ
US4986830A (en) * 1989-09-22 1991-01-22 Schneider (U.S.A.) Inc. Valvuloplasty catheter with balloon which remains stable during inflation
US5108370A (en) 1989-10-03 1992-04-28 Paul Walinsky Perfusion balloon catheter
US5089015A (en) * 1989-11-28 1992-02-18 Promedica International Method for implanting unstented xenografts and allografts
US5591185A (en) * 1989-12-14 1997-01-07 Corneal Contouring Development L.L.C. Method and apparatus for reprofiling or smoothing the anterior or stromal cornea by scraping
US5141494A (en) * 1990-02-15 1992-08-25 Danforth Biomedical, Inc. Variable wire diameter angioplasty dilatation balloon catheter
US5037434A (en) 1990-04-11 1991-08-06 Carbomedics, Inc. Bioprosthetic heart valve with elastic commissures
US5059177A (en) 1990-04-19 1991-10-22 Cordis Corporation Triple lumen balloon catheter
DK124690D0 (en) 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes for implantation in the body for replacement of the natural folding and catheter for use in the implantation of such a prosthesis flap
US5085635A (en) * 1990-05-18 1992-02-04 Cragg Andrew H Valved-tip angiographic catheter
GB9012716D0 (en) * 1990-06-07 1990-08-01 Frater Robert W M Mitral heart valve replacements
US5674192A (en) * 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
US5489298A (en) * 1991-01-24 1996-02-06 Autogenics Rapid assembly concentric mating stent, tissue heart valve with enhanced clamping and tissue exposure
US5282847A (en) 1991-02-28 1994-02-01 Medtronic, Inc. Prosthetic vascular grafts with a pleated structure
JPH05184611A (en) 1991-03-19 1993-07-27 Kenji Kusuhara Valvular annulation retaining member and its attaching method
US5295958A (en) * 1991-04-04 1994-03-22 Shturman Cardiology Systems, Inc. Method and apparatus for in vivo heart valve decalcification
US5167628A (en) 1991-05-02 1992-12-01 Boyles Paul W Aortic balloon catheter assembly for indirect infusion of the coronary arteries
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5558644A (en) * 1991-07-16 1996-09-24 Heartport, Inc. Retrograde delivery catheter and method for inducing cardioplegic arrest
US5769812A (en) * 1991-07-16 1998-06-23 Heartport, Inc. System for cardiac procedures
US5584803A (en) * 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
US5232446A (en) 1991-10-30 1993-08-03 Scimed Life Systems, Inc. Multi-sinus perfusion balloon dilatation catheter
US5192297A (en) * 1991-12-31 1993-03-09 Medtronic, Inc. Apparatus and method for placement and implantation of a stent
US5756476A (en) * 1992-01-14 1998-05-26 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell proliferation using antisense oligonucleotides
US5163953A (en) 1992-02-10 1992-11-17 Vince Dennis J Toroidal artificial heart valve stent
US5683448A (en) * 1992-02-21 1997-11-04 Boston Scientific Technology, Inc. Intraluminal stent and graft
US5332402A (en) * 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
CA2475058C (en) * 1992-10-13 2008-12-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
DE4327825C2 (en) * 1992-11-24 1996-10-02 Mannesmann Ag Throttle check element
US6283127B1 (en) 1992-12-03 2001-09-04 Wesley D. Sterman Devices and methods for intracardiac procedures
US6346074B1 (en) * 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
GB9312666D0 (en) * 1993-06-18 1993-08-04 Vesely Ivan Bioprostetic heart valve
CA2125258C (en) 1993-08-05 1998-12-22 Dinah B Quiachon Multicapsule intraluminal grafting system and method
US5411522A (en) 1993-08-25 1995-05-02 Linvatec Corporation Unitary anchor for soft tissue fixation
US5545209A (en) * 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
US5480424A (en) * 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US6245040B1 (en) 1994-01-14 2001-06-12 Cordis Corporation Perfusion balloon brace and method of use
US6102845A (en) * 1994-02-07 2000-08-15 Baxter International Inc. Ventricular assist device with minimal blood contacting surfaces
US5609627A (en) * 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
EP0705081B1 (en) 1994-04-22 2001-10-17 Medtronic, Inc. Stented bioprosthetic heart valve
DE69527141T2 (en) 1994-04-29 2002-11-07 Scimed Life Systems Inc Stent with collagen
US5728068A (en) 1994-06-14 1998-03-17 Cordis Corporation Multi-purpose balloon catheter
US5554185A (en) * 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5761417A (en) * 1994-09-08 1998-06-02 International Business Machines Corporation Video data streamer having scheduler for scheduling read request for individual data buffers associated with output ports of communication node to one storage node
US5599305A (en) 1994-10-24 1997-02-04 Cardiovascular Concepts, Inc. Large-diameter introducer sheath having hemostasis valve and removable steering mechanism
CA2134997C (en) 1994-11-03 2009-06-02 Ian M. Penn Stent
US5639274A (en) * 1995-06-02 1997-06-17 Fischell; Robert E. Integrated catheter system for balloon angioplasty and stent delivery
US5571175A (en) 1995-06-07 1996-11-05 St. Jude Medical, Inc. Suture guard for prosthetic heart valve
US5716417A (en) * 1995-06-07 1998-02-10 St. Jude Medical, Inc. Integral supporting structure for bioprosthetic heart valve
US5728152A (en) 1995-06-07 1998-03-17 St. Jude Medical, Inc. Bioresorbable heart valve support
WO1997000651A1 (en) * 1995-06-20 1997-01-09 Agathos Efstathios A Human valve replacement with marine mammal valve
DE19532846A1 (en) 1995-09-06 1997-03-13 Georg Dr Berg Valve for use in heart
US5824037A (en) * 1995-10-03 1998-10-20 Medtronic, Inc. Modular intraluminal prostheses construction and methods
US5591195A (en) * 1995-10-30 1997-01-07 Taheri; Syde Apparatus and method for engrafting a blood vessel
DE19546692C2 (en) 1995-12-14 2002-11-07 Hans-Reiner Figulla Self-expanding heart valve prosthesis for implantation in the human body via a catheter system
FR2742994B1 (en) 1995-12-28 1998-04-03 Sgro Jean-Claude Set of surgical treatment of an intracorporeal lumen
US5716370A (en) * 1996-02-23 1998-02-10 Williamson, Iv; Warren Means for replacing a heart valve in a minimally invasive manner
DE69719237D1 (en) * 1996-05-23 2003-04-03 Samsung Electronics Co Ltd Flexible, self-expanding stent and method for its production
US5855601A (en) 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US6217585B1 (en) * 1996-08-16 2001-04-17 Converge Medical, Inc. Mechanical stent and graft delivery system
US5968069A (en) 1996-08-23 1999-10-19 Scimed Life Systems, Inc. Stent delivery system having stent securement apparatus
US5855602A (en) 1996-09-09 1999-01-05 Shelhigh, Inc. Heart valve prosthesis
US5968068A (en) 1996-09-12 1999-10-19 Baxter International Inc. Endovascular delivery system
US5749890A (en) 1996-12-03 1998-05-12 Shaknovich; Alexander Method and system for stent placement in ostial lesions
NL1004827C2 (en) 1996-12-18 1998-06-19 Surgical Innovations Vof Device for the regulation of the circulatory system.
US6074419A (en) * 1996-12-31 2000-06-13 St. Jude Medical, Inc. Indicia for prosthetic device
EP0850607A1 (en) * 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
GB9701479D0 (en) * 1997-01-24 1997-03-12 Aortech Europ Ltd Heart valve
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6206917B1 (en) 1997-05-02 2001-03-27 St. Jude Medical, Inc. Differential treatment of prosthetic devices
US5855597A (en) * 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US6245102B1 (en) * 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US6056722A (en) 1997-09-18 2000-05-02 Iowa-India Investments Company Limited Of Douglas Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and methods of use
US5984959A (en) 1997-09-19 1999-11-16 United States Surgical Heart valve replacement tools and procedures
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6530952B2 (en) * 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
CA2315211A1 (en) * 1997-12-29 1999-07-08 The Cleveland Clinic Foundation System for minimally invasive insertion of a bioprosthetic heart valve
EP0935978A1 (en) 1998-02-16 1999-08-18 Medicorp S.A. Angioplasty and stent delivery catheter
US6174327B1 (en) * 1998-02-27 2001-01-16 Scimed Life Systems, Inc. Stent deployment apparatus and method
EP0943300A1 (en) 1998-03-17 1999-09-22 Medicorp S.A. Reversible action endoprosthesis delivery device.
US5980570A (en) 1998-03-27 1999-11-09 Sulzer Carbomedics Inc. System and method for implanting an expandable medical device into a body
US6545799B1 (en) * 1998-09-02 2003-04-08 Corning Incorporated Method and apparatus for optical system link control
US6334873B1 (en) 1998-09-28 2002-01-01 Autogenics Heart valve having tissue retention with anchors and an outer sheath
DE19857887B4 (en) 1998-12-15 2005-05-04 Markus Dr.med. Dr.disc.pol. Ferrari Anchoring support for a heart valve prosthesis
FR2788217A1 (en) 1999-01-12 2000-07-13 Brice Letac Implantable prosthetic valve by catheterization, or surgically
US6350277B1 (en) * 1999-01-15 2002-02-26 Scimed Life Systems, Inc. Stents with temporary retaining bands
US6425916B1 (en) * 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
DE19907646A1 (en) 1999-02-23 2000-08-24 Georg Berg Valve for blood vessels uses flap holders and counterpart holders on stent to latch together in place and all channeled for guide wire.
US6210408B1 (en) * 1999-02-24 2001-04-03 Scimed Life Systems, Inc. Guide wire system for RF recanalization of vascular blockages
US6231602B1 (en) * 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
EP1057460A1 (en) 1999-06-01 2000-12-06 Numed, Inc. Replacement valve assembly and method of implanting same
US6299637B1 (en) 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
US6685724B1 (en) 1999-08-24 2004-02-03 The Penn State Research Foundation Laparoscopic surgical instrument and method
US6527979B2 (en) 1999-08-27 2003-03-04 Corazon Technologies, Inc. Catheter systems and methods for their use in the treatment of calcified vascular occlusions
ES2243188T3 (en) 1999-09-30 2005-12-01 Sorin Biomedica Cardio S.R.L. A device for operations of repairing or replacing heart valves.
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
FR2800984B1 (en) 1999-11-17 2001-12-14 Jacques Seguin Device for replacing a heart valve percutaneously
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
DE19955490A1 (en) 1999-11-18 2001-06-13 Thermamed Gmbh Medical devices heat device
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
ES2307590T3 (en) 2000-01-27 2008-12-01 3F Therapeutics, Inc Prosthetic heart valve.
CA2840468C (en) 2000-01-31 2016-07-26 Cook Biotech Incorporated Stent valves and uses of same
DE10010074B4 (en) 2000-02-28 2005-04-14 Ferrari, Markus, Dr.med. Dr.disc.pol. Device for fastening and anchoring of cardiac valve prostheses
DE10010073B4 (en) 2000-02-28 2005-12-22 Ferrari, Markus, Dr.med. Dr.disc.pol. Anchor for implantable heart valve prostheses
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
JP2004501711A (en) 2000-05-16 2004-01-22 タウト インコーポレイテッド Trocar assembly for puncturing tip
US6869444B2 (en) 2000-05-22 2005-03-22 Shlomo Gabbay Low invasive implantable cardiac prosthesis and method for helping improve operation of a heart valve
US6419695B1 (en) 2000-05-22 2002-07-16 Shlomo Gabbay Cardiac prosthesis for helping improve operation of a heart valve
EP1401358B1 (en) * 2000-06-30 2016-08-17 Medtronic, Inc. Apparatus for performing a procedure on a cardiac valve
WO2002022054A1 (en) 2000-09-12 2002-03-21 Gabbay S Valvular prosthesis and method of using same
US7510572B2 (en) * 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
US6613063B1 (en) 2000-10-03 2003-09-02 Daniel Hunsberger Trocar assembly
DE10049815B4 (en) 2000-10-09 2005-10-13 Universitätsklinikum Freiburg Device for the local removal of an aortic valve on the human or animal heart
DE10049813C1 (en) 2000-10-09 2002-04-18 Universitaetsklinikum Freiburg Instrument for the local removal of built-up matter at an aortic valve, in a human or animal heart, is a hollow catheter with a cutting unit at the far end within a closure cap for minimum invasion
DE10049814B4 (en) 2000-10-09 2006-10-19 Albert-Ludwigs-Universität Apparatus for assisting surgical procedures within a vessel, especially for minimally invasive explantation and implantation of heart valves
DE10049812B4 (en) 2000-10-09 2004-06-03 Universitätsklinikum Freiburg Apparatus for filtering of macroscopic particles from the blood stream to the local removal of an aortic valve on the human or animal heart
FR2815844B1 (en) 2000-10-31 2003-01-17 Jacques Seguin tubular support in place, percutaneously, a replacement heart valve
US6482228B1 (en) 2000-11-14 2002-11-19 Troy R. Norred Percutaneous aortic valve replacement
DE60112603T2 (en) 2000-11-21 2006-06-14 Rex Medical Lp percutaneous aortic valve
US6494909B2 (en) 2000-12-01 2002-12-17 Prodesco, Inc. Endovascular valve
US20040093075A1 (en) 2000-12-15 2004-05-13 Titus Kuehne Stent with valve and method of use thereof
US6468660B2 (en) 2000-12-29 2002-10-22 St. Jude Medical, Inc. Biocompatible adhesives
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US7374571B2 (en) 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
US6488704B1 (en) 2001-05-07 2002-12-03 Biomed Solutions, Llc Implantable particle measuring apparatus
US6936067B2 (en) 2001-05-17 2005-08-30 St. Jude Medical Inc. Prosthetic heart valve with slit stent
US7556646B2 (en) 2001-09-13 2009-07-07 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
WO2003043676A3 (en) 2001-11-23 2003-11-27 Mindguard Ltd Expandable delivery appliance particularly for delivering intravascular devices
US7182779B2 (en) 2001-12-03 2007-02-27 Xtent, Inc. Apparatus and methods for positioning prostheses for deployment from a catheter
US7887573B2 (en) 2002-02-22 2011-02-15 Boston Scientific Scimed, Inc. Method and apparatus for deployment of an endoluminal device
US6830586B2 (en) 2002-02-28 2004-12-14 3F Therapeutics, Inc. Stentless atrioventricular heart valve fabricated from a singular flat membrane
US7141064B2 (en) 2002-05-08 2006-11-28 Edwards Lifesciences Corporation Compressed tissue for heart valve leaflets
US8348963B2 (en) 2002-07-03 2013-01-08 Hlt, Inc. Leaflet reinforcement for regurgitant valves
US6878162B2 (en) 2002-08-30 2005-04-12 Edwards Lifesciences Ag Helical stent having improved flexibility and expandability
JP2006526464A (en) 2003-06-05 2006-11-24 フローメディカ,インコーポレイテッド System and method for bilateral intervention or diagnostic in branched body lumens
US7137184B2 (en) 2002-09-20 2006-11-21 Edwards Lifesciences Corporation Continuous heart valve support frame and method of manufacture
US7381210B2 (en) 2003-03-14 2008-06-03 Edwards Lifesciences Corporation Mitral valve repair system and method for use
US7399315B2 (en) 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
JP4940388B2 (en) 2003-04-24 2012-05-30 クック メディカル テクノロジーズ エルエルシーCook Medical Technologies Llc Prosthetic valve proteinase with improved hydrodynamic characteristics - Ze
EP1653888B1 (en) 2003-07-21 2009-09-09 The Trustees of The University of Pennsylvania Percutaneous heart valve
US7160322B2 (en) 2003-08-13 2007-01-09 Shlomo Gabbay Implantable cardiac prosthesis for mitigating prolapse of a heart valve
US20050075725A1 (en) 2003-10-02 2005-04-07 Rowe Stanton J. Implantable prosthetic valve with non-laminar flow
US20060259137A1 (en) 2003-10-06 2006-11-16 Jason Artof Minimally invasive valve replacement system
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US8052749B2 (en) 2003-12-23 2011-11-08 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7470285B2 (en) 2004-02-05 2008-12-30 Children's Medical Center Corp. Transcatheter delivery of a replacement heart valve
CA2557657C (en) 2004-02-27 2013-06-18 Aortx, Inc. Prosthetic heart valve delivery systems and methods
US8109996B2 (en) 2004-03-03 2012-02-07 Sorin Biomedica Cardio, S.R.L. Minimally-invasive cardiac-valve prosthesis
JP2007535342A (en) 2004-03-11 2007-12-06 パーキュテイニアス カルディオバスキュラー ソリューションズ ピー・ティー・ワイ リミテッド Percutaneous prosthetic heart valve
US20060004323A1 (en) 2004-04-21 2006-01-05 Exploramed Nc1, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
WO2005102015A3 (en) 2004-04-23 2007-04-19 3F Therapeutics Inc Implantable prosthetic valve
US20050288766A1 (en) 2004-06-28 2005-12-29 Xtent, Inc. Devices and methods for controlling expandable prostheses during deployment
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
CN101056596B (en) 2004-09-14 2011-08-03 爱德华兹生命科学股份公司 Device and method for treatment of heart valve regurgitation
US7579381B2 (en) 2005-03-25 2009-08-25 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US8062359B2 (en) 2005-04-06 2011-11-22 Edwards Lifesciences Corporation Highly flexible heart valve connecting band
EP1893131A1 (en) 2005-04-20 2008-03-05 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
US20060241745A1 (en) 2005-04-21 2006-10-26 Solem Jan O Blood flow controlling apparatus
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US20080058856A1 (en) 2005-06-28 2008-03-06 Venkatesh Ramaiah Non-occluding dilation device
JP2007011557A (en) 2005-06-29 2007-01-18 Nissan Motor Co Ltd Traffic jam detection system, onboard information terminal, information center, and method for detecting traffic jam
US8790396B2 (en) 2005-07-27 2014-07-29 Medtronic 3F Therapeutics, Inc. Methods and systems for cardiac valve delivery
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US8449606B2 (en) 2005-10-26 2013-05-28 Cardiosolutions, Inc. Balloon mitral spacer
US7785366B2 (en) 2005-10-26 2010-08-31 Maurer Christopher W Mitral spacer
US8778017B2 (en) 2005-10-26 2014-07-15 Cardiosolutions, Inc. Safety for mitral valve implant
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
EP1988851A2 (en) 2006-02-14 2008-11-12 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US8147541B2 (en) 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8932348B2 (en) 2006-05-18 2015-01-13 Edwards Lifesciences Corporation Device and method for improving heart valve function
CN102247223B (en) 2006-09-08 2015-05-06 爱德华兹生命科学公司 Integrated heart valve delivery system
US8876895B2 (en) 2006-09-19 2014-11-04 Medtronic Ventor Technologies Ltd. Valve fixation member having engagement arms
US8029556B2 (en) 2006-10-04 2011-10-04 Edwards Lifesciences Corporation Method and apparatus for reshaping a ventricle
EP2077718B1 (en) 2006-10-27 2014-12-03 Edwards Lifesciences Corporation Biological tissue for surgical implantation
US7655034B2 (en) 2006-11-14 2010-02-02 Medtronic Vascular, Inc. Stent-graft with anchoring pins
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
US9510943B2 (en) 2007-01-19 2016-12-06 Medtronic, Inc. Stented heart valve devices and methods for atrioventricular valve replacement
US20080294248A1 (en) 2007-05-25 2008-11-27 Medical Entrepreneurs Ii, Inc. Prosthetic Heart Valve
EP2698129A1 (en) 2007-06-04 2014-02-19 St. Jude Medical, Inc. Prosthetic heart valve
EP2192875B1 (en) 2007-08-24 2012-05-02 St. Jude Medical, Inc. Prosthetic aortic heart valves
DE102007043830A1 (en) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Heart valve stent
EP2231070B1 (en) 2007-12-14 2013-05-22 Edwards Lifesciences Corporation Leaflet attachment frame for a prosthetic valve
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US20090171456A1 (en) 2007-12-28 2009-07-02 Kveen Graig L Percutaneous heart valve, system, and method
CA2714062A1 (en) 2008-01-24 2009-07-30 Medtronic, Inc. Stents for prosthetic heart valves
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
JP2009252172A (en) 2008-04-10 2009-10-29 Fujitsu Component Ltd Remote operation system
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US9061119B2 (en) 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
ES2645920T3 (en) 2008-06-06 2017-12-11 Edwards Lifesciences Corporation Transcatheter heart valve low profile
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
ES2584315T3 (en) 2008-07-15 2016-09-27 St. Jude Medical, Inc. Collapsible designs and reexpansible Prosthetic heart valve sleeve and complementary technological applications
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US20100262233A1 (en) 2009-04-12 2010-10-14 Texas Tech University System Mitral Valve Coaptation Plate For Mitral Valve Regurgitation
EP2419050B1 (en) 2009-04-15 2017-06-28 Edwards Lifesciences CardiAQ LLC Vascular implant and delivery system
US8475522B2 (en) 2009-07-14 2013-07-02 Edwards Lifesciences Corporation Transapical delivery system for heart valves
CA2813419A1 (en) 2010-10-05 2012-04-12 Edwards Lifesciences Corporation Prosthetic heart valve
US8888843B2 (en) 2011-01-28 2014-11-18 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
WO1993001768A1 (en) * 1991-07-16 1993-02-04 Stevens John H Endovascular aortic valve replacement

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M.D. DAKE, NEW ENGL. J. MED., vol. 331, 1994, pages 1729 - 1734

Cited By (454)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7789909B2 (en) 1990-05-18 2010-09-07 Edwards Lifesciences Ag System for implanting a valve prosthesis
US8915959B2 (en) 1991-07-16 2014-12-23 Heartport, Inc. Endovascular aortic valve replacement
US7846203B2 (en) 1996-12-31 2010-12-07 Edwards Lifesciences Pvt, Inc. Implanting a stent valve prosthesis at the native aortic valve
US9095432B2 (en) 1996-12-31 2015-08-04 Edwards Lifesciences Pvt, Inc. Collapsible prosthetic valve having an internal cover
US9629714B2 (en) 1996-12-31 2017-04-25 Edwards Lifesciences Pvt, Inc. Collapsible prosthetic valve
US9486312B2 (en) 1996-12-31 2016-11-08 Edwards Lifesciences Pvt, Inc. Method of manufacturing a prosthetic valve
US7722667B1 (en) * 1998-04-20 2010-05-25 St. Jude Medical, Inc. Two piece bioprosthetic heart valve with matching outer frame and inner valve
US8444687B2 (en) 1998-06-02 2013-05-21 Cook Medical Technologies Llc Implantable vascular device
US6508833B2 (en) 1998-06-02 2003-01-21 Cook Incorporated Multiple-sided intraluminal medical device
US8613763B2 (en) 1998-06-02 2013-12-24 Cook Medical Technologies Llc Implantable vascular device
US6974474B2 (en) 1998-06-02 2005-12-13 Cook Incorporated Multiple-sided intraluminal medical device
US7118600B2 (en) * 1998-08-31 2006-10-10 Wilson-Cook Medical, Inc. Prosthesis having a sleeve valve
WO2000023006A1 (en) * 1998-10-16 2000-04-27 Sulzer Carbomedics Inc. Elastic valve with partially exposed stent
US6270527B1 (en) 1998-10-16 2001-08-07 Sulzer Carbomedics Inc. Elastic valve with partially exposed stent
WO2000041652A1 (en) * 1999-01-12 2000-07-20 Brice Letac Prosthetic heart valve implantable by catheter insertion or surgically
FR2788217A1 (en) 1999-01-12 2000-07-13 Brice Letac Implantable prosthetic valve by catheterization, or surgically
US8591574B2 (en) 1999-01-27 2013-11-26 Medtronic, Inc. Cardiac valve procedure methods and devices
US9192467B2 (en) 1999-01-27 2015-11-24 Medtronic, Inc. Valve prostheses
US7470284B2 (en) 1999-01-27 2008-12-30 Medtronic, Inc. Cardiac valve procedure methods and devices
US8740974B2 (en) 1999-01-27 2014-06-03 Medtronic, Inc. Cardiac valve procedure methods and devices
EP1154738A1 (en) * 1999-01-27 2001-11-21 Viacor Incorporated Cardiac valve procedure methods and devices
US9101470B2 (en) 1999-01-27 2015-08-11 Medtronic, Inc. Cardiac valve procedure methods and devices
CN1775190B (en) 1999-01-27 2010-06-16 梅德特龙尼克有限公司 Cardiac valve procedure methods and devices
EP1154738A4 (en) * 1999-01-27 2006-11-22 Medtronic Inc Cardiac valve procedure methods and devices
EP1164976A4 (en) * 1999-02-10 2005-03-16 Heartport Inc Methods and devices for implanting cardiac valves
EP1164976A1 (en) * 1999-02-10 2002-01-02 Heartport, Inc. Methods and devices for implanting cardiac valves
WO2000047139A1 (en) * 1999-02-10 2000-08-17 Heartport, Inc. Methods and devices for implanting cardiac valves
US6425916B1 (en) * 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US7452371B2 (en) 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
US7918882B2 (en) 1999-06-02 2011-04-05 Cook Medical Technologies Llc Implantable vascular device comprising a bioabsorbable frame
JP2009261965A (en) * 1999-09-10 2009-11-12 Cook Inc Endovascular valve assembly, and methods of manufacturing the valve assembly
EP1229865A1 (en) * 1999-09-10 2002-08-14 Francisco J. Osse Endovascular treatment for chronic venous insufficiency
EP1229865A4 (en) * 1999-09-10 2004-03-31 Cook Inc Endovascular treatment for chronic venous insufficiency
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US6685739B2 (en) 1999-10-21 2004-02-03 Scimed Life Systems, Inc. Implantable prosthetic valve
WO2001028459A1 (en) * 1999-10-21 2001-04-26 Scimed Life Systems, Inc. Implantable prosthetic valve
EP1977719A3 (en) * 1999-10-21 2011-05-04 Boston Scientific Limited Method of forming an implantable prosthetic valve
US6840957B2 (en) 1999-10-21 2005-01-11 Scimed Life Systems, Inc. Implantable prosthetic valve
US6705317B2 (en) 1999-10-22 2004-03-16 3M Innovative Properties Company Retention assembly with compression element and method of use
US6729332B1 (en) 1999-10-22 2004-05-04 3M Innovative Properties Company Retention assembly with compression element and method of use
US8876896B2 (en) 1999-11-17 2014-11-04 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US9060856B2 (en) 1999-11-17 2015-06-23 Medtronic Corevalve Llc Transcatheter heart valves
US9066799B2 (en) 1999-11-17 2015-06-30 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7892281B2 (en) 1999-11-17 2011-02-22 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
USRE45865E1 (en) 1999-11-17 2016-01-26 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8986329B2 (en) 1999-11-17 2015-03-24 Medtronic Corevalve Llc Methods for transluminal delivery of prosthetic valves
US8998979B2 (en) 1999-11-17 2015-04-07 Medtronic Corevalve Llc Transcatheter heart valves
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US9962258B2 (en) 1999-11-17 2018-05-08 Medtronic CV Luxembourg S.a.r.l. Transcatheter heart valves
US8910363B2 (en) 1999-11-19 2014-12-16 Advanced Bio Prosthetic Surfaces, Ltd. Compliant implantable medical devices and methods of making same
US7018408B2 (en) 1999-12-31 2006-03-28 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
EP2289466A1 (en) * 1999-12-31 2011-03-02 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6652578B2 (en) 1999-12-31 2003-11-25 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
WO2001049213A3 (en) * 1999-12-31 2002-01-24 Advanced Bio Prosthetic Surfac Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US8992597B2 (en) 1999-12-31 2015-03-31 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US7799069B2 (en) 1999-12-31 2010-09-21 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US9421100B2 (en) 1999-12-31 2016-08-23 ABPS Venture One, Ltd., a wholly owned subsidiary of Palmaz Scientific, Inc. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US7338520B2 (en) 1999-12-31 2008-03-04 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US8221493B2 (en) 1999-12-31 2012-07-17 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
WO2001052775A1 (en) * 2000-01-17 2001-07-26 Wittens Cornelis Hendrikus Ann Implant valve for implantation in a blood vessel
US7811315B2 (en) 2000-01-17 2010-10-12 Cornelis Hendrikus Anna Wittens Implant valve for implantation in a blood vessel
NL1014095C2 (en) * 2000-01-17 2001-07-18 Cornelis Hendrikus Anna Witten Implant valve for implantation in a blood vessel.
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US9949831B2 (en) 2000-01-19 2018-04-24 Medtronics, Inc. Image-guided heart valve placement
WO2001054625A1 (en) * 2000-01-31 2001-08-02 Cook Biotech Incorporated Stent valves and uses of same
EP1900343A3 (en) * 2000-01-31 2008-03-26 Cook Biotech, Inc. Stent valves and uses of same
EP2329796A3 (en) * 2000-01-31 2012-03-28 Cook Biotech, Inc. Stent valves and uses of same
JP2004500189A (en) * 2000-01-31 2004-01-08 クック・バイオテック・インコーポレーテッド Stent-valve and methods of use thereof
US8906083B2 (en) 2000-01-31 2014-12-09 Cook Biotech Incorporated Stent valves and uses of same
US7520894B2 (en) 2000-02-03 2009-04-21 Cook Incorporated Implantable vascular device
US8092518B2 (en) 2000-04-06 2012-01-10 Edwards Lifesciences Corporation Methods of implanting two-part heart valves
US8349000B2 (en) 2000-04-06 2013-01-08 Edwards Lifesciences Corporation Minimally-invasive heart valves
US7381218B2 (en) 2000-04-06 2008-06-03 Edwards Lifesciences Corporation System and method for implanting a two-part prosthetic heart valve
US6767362B2 (en) 2000-04-06 2004-07-27 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US10022220B2 (en) 2000-04-06 2018-07-17 Edwards Lifesciences Corporation Methods of implanting minimally-invasive prosthetic heart valves
US6869444B2 (en) 2000-05-22 2005-03-22 Shlomo Gabbay Low invasive implantable cardiac prosthesis and method for helping improve operation of a heart valve
JP2004514467A (en) * 2000-06-26 2004-05-20 レックス メディカル リミテッド パートナーシップ Vascular device for close to a small leaf-like valvular
WO2002022054A1 (en) * 2000-09-12 2002-03-21 Gabbay S Valvular prosthesis and method of using same
WO2002024119A1 (en) * 2000-09-21 2002-03-28 St. Jude Medical, Inc. Valved prostheses with reinforced polymer leaflets
US6953332B1 (en) 2000-11-28 2005-10-11 St. Jude Medical, Inc. Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
US8038708B2 (en) 2001-02-05 2011-10-18 Cook Medical Technologies Llc Implantable device with remodelable material and covering material
US9241788B2 (en) 2001-03-23 2016-01-26 Edwards Lifesciences Corporation Method for treating an aortic valve
US9707074B2 (en) 2001-03-23 2017-07-18 Edwards Lifesciences Corporation Method for treating an aortic valve
US8206438B2 (en) 2001-03-23 2012-06-26 Edwards Lifesciences Corporation Prosthetic heart valve having flared outflow section
WO2003003943A2 (en) 2001-07-03 2003-01-16 Advanced Bio Prosthetic Surfaces, Ltd Valvular prostheses having metal or pseudometallic construction and methods of manufacture
EP1408895A2 (en) * 2001-07-03 2004-04-21 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
JP2004531355A (en) * 2001-07-03 2004-10-14 アドヴァンスド バイオ プロスセティック サーフェシーズ リミテッド Valvular prosthesis and a method for producing a metal or pseudo metal structure
EP1408895A4 (en) * 2001-07-03 2008-05-07 Advanced Bio Prothestic Surfac Valvular prostheses having metal or pseudometallic construction and methods of manufacture
EP2298252A1 (en) * 2001-07-03 2011-03-23 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US8458879B2 (en) 2001-07-03 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Method of fabricating an implantable medical device
WO2003003943A3 (en) * 2001-07-03 2003-11-06 Advanced Bio Prosthetic Surfac Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US7252682B2 (en) 2001-07-04 2007-08-07 Corevalve, S.A. Kit enabling a prosthetic valve to be placed in a body enabling a prosthetic valve to be put into place in a duct in the body
US7780726B2 (en) 2001-07-04 2010-08-24 Medtronic, Inc. Assembly for placing a prosthetic valve in a duct in the body
US9149357B2 (en) 2001-07-04 2015-10-06 Medtronic CV Luxembourg S.a.r.l. Heart valve assemblies
US8002826B2 (en) 2001-07-04 2011-08-23 Medtronic Corevalve Llc Assembly for placing a prosthetic valve in a duct in the body
US8628570B2 (en) 2001-07-04 2014-01-14 Medtronic Corevalve Llc Assembly for placing a prosthetic valve in a duct in the body
US7682390B2 (en) * 2001-07-31 2010-03-23 Medtronic, Inc. Assembly for setting a valve prosthesis in a corporeal duct
US9539091B2 (en) 2001-09-13 2017-01-10 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US9452046B2 (en) 2001-09-13 2016-09-27 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US8740975B2 (en) 2001-09-13 2014-06-03 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US9572664B2 (en) 2001-09-13 2017-02-21 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US9168136B2 (en) 2001-09-13 2015-10-27 Edwards Lifesciences Corporation Methods for deploying self-expanding heart valves
WO2003022183A1 (en) * 2001-09-13 2003-03-20 Edwards Lifesciences Corporation Apparatuses for deploying minimally-invasive heart valves
US9848985B2 (en) 2001-09-13 2017-12-26 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US9572663B2 (en) 2001-09-13 2017-02-21 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US6562069B2 (en) 2001-09-19 2003-05-13 St. Jude Medical, Inc. Polymer leaflet designs for medical devices
EP1441672A1 (en) * 2001-10-11 2004-08-04 Percutaneous Valve Technologies Implantable prosthetic valve
US9629717B2 (en) 2001-10-11 2017-04-25 Edwards Lifesciences Pvt, Inc. Prosthetic heart valve and method
US9132006B2 (en) 2001-10-11 2015-09-15 Edwards Lifesciences Pvt, Inc. Prosthetic heart valve and method
EP1441672A4 (en) * 2001-10-11 2006-06-14 Percutaneous Valve Technologie Implantable prosthetic valve
US10052203B2 (en) 2001-10-11 2018-08-21 Edwards Lifesciences Pvt, Inc. Prosthetic heart valve and method
US9937039B2 (en) 2001-10-11 2018-04-10 Edwards Lifesciences Pvt, Inc. Prosthetic heart valve and method
US9339383B2 (en) 2001-10-11 2016-05-17 Edwards Lifesciences Pvt, Inc. Prosthetic heart valve and method
US8721713B2 (en) 2002-04-23 2014-05-13 Medtronic, Inc. System for implanting a replacement valve
US8858619B2 (en) 2002-04-23 2014-10-14 Medtronic, Inc. System and method for implanting a replacement valve
US8663541B2 (en) 2002-05-10 2014-03-04 Cordis Corporation Method of forming a tubular membrane on a structural frame
US7270675B2 (en) 2002-05-10 2007-09-18 Cordis Corporation Method of forming a tubular membrane on a structural frame
US7758632B2 (en) 2002-05-10 2010-07-20 Cordis Corporation Frame based unidirectional flow prosthetic implant
WO2004034933A2 (en) * 2002-05-10 2004-04-29 Cordis Corporation Frame based unidirectional flow prosthetic implant
WO2004034933A3 (en) * 2002-05-10 2004-07-08 Cordis Corp Frame based unidirectional flow prosthetic implant
US7351256B2 (en) 2002-05-10 2008-04-01 Cordis Corporation Frame based unidirectional flow prosthetic implant
US7485141B2 (en) 2002-05-10 2009-02-03 Cordis Corporation Method of placing a tubular membrane on a structural frame
US7828839B2 (en) 2002-05-16 2010-11-09 Cook Incorporated Flexible barb for anchoring a prosthesis
US8163008B2 (en) 2002-08-28 2012-04-24 Heart Leaflet Technologies, Inc. Leaflet valve
US7217287B2 (en) * 2002-08-28 2007-05-15 Heart Leaflet Technologies, Inc. Method of treating diseased valve
US8551162B2 (en) * 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US9333078B2 (en) 2002-12-20 2016-05-10 Medtronic, Inc. Heart valve assemblies
US8623080B2 (en) 2002-12-20 2014-01-07 Medtronic, Inc. Biologically implantable prosthesis and methods of using the same
US7981153B2 (en) * 2002-12-20 2011-07-19 Medtronic, Inc. Biologically implantable prosthesis methods of using
US8025695B2 (en) 2002-12-20 2011-09-27 Medtronic, Inc. Biologically implantable heart valve system
US8460373B2 (en) 2002-12-20 2013-06-11 Medtronic, Inc. Method for implanting a heart valve within an annulus of a patient
US9675455B2 (en) 2003-03-18 2017-06-13 Edwards Lifesciences Corporation Method of positioning a minimally-invasive heart valve with cusp positioners
US9724193B2 (en) 2003-03-18 2017-08-08 Edwards Lifesciences Corporation Self-expandable heart valve with stabilizers
US8778018B2 (en) 2003-03-18 2014-07-15 Mario M. Iobbi Method of implanting a minimally-invasive heart valve with cusp positioners
US9320598B2 (en) 2003-03-18 2016-04-26 Edwards Lifesciences Corporation Method of implanting a self-expandable prosthetic heart valve
US9504567B2 (en) 2003-03-18 2016-11-29 Edwards Lifesciences Corporation Minimally-invasive prosthetic heart valve method
US7854763B2 (en) 2003-03-21 2010-12-21 Leman Cardiovascular Sa Intraparietal aortic valve reinforcement device and reinforced aortic valve
WO2004082537A1 (en) * 2003-03-21 2004-09-30 Raymond Andrieu Intraparietal aortic valve reinforcement device and reinforced aortic valve
JP4838707B2 (en) * 2003-03-21 2011-12-14 リーマン カーディオヴァスキュラー ソシエテ アノニム Biological body cavity wall of the prosthesis reinforcement device and reinforced biological prosthesis
JP2006523114A (en) * 2003-03-21 2006-10-12 レイモン アンドリュー Biological body cavity wall of the prosthesis reinforcement device and reinforced biological prosthesis
US8470020B2 (en) 2003-04-24 2013-06-25 Cook Medical Technologies Llc Intralumenally-implantable frames
EP2133039A1 (en) * 2003-04-24 2009-12-16 Cook Incorporated Artificial valve prosthesis with improved flow dynamics
US9421096B2 (en) 2003-04-24 2016-08-23 Cook Medical Technologies Llc Artificial valve prosthesis with improved flow dynamics
US8771338B2 (en) 2003-04-24 2014-07-08 Cook Medical Technologies Llc Intralumenally-implantable frames
US8157857B2 (en) 2003-04-24 2012-04-17 Cook Medical Technologies Llc Intralumenally-implantable frames
JP2006524119A (en) * 2003-04-24 2006-10-26 クック インコーポレイティドCook Incorporated Prosthetic valve proteinase with improved hydrodynamic characteristics - Ze
WO2004096100A1 (en) * 2003-04-24 2004-11-11 Cook Incorporated Artificial valve prosthesis with improved flow dynamics
US9326871B2 (en) 2003-04-24 2016-05-03 Cook Medical Technologies Llc Intralumenally-implantable frames
US8221492B2 (en) 2003-04-24 2012-07-17 Cook Medical Technologies Artificial valve prosthesis with improved flow dynamics
US8512403B2 (en) * 2003-05-20 2013-08-20 The Cleveland Clinic Foundation Annuloplasty ring with wing members for repair of a cardiac valve
US7160322B2 (en) 2003-08-13 2007-01-09 Shlomo Gabbay Implantable cardiac prosthesis for mitigating prolapse of a heart valve
US8747463B2 (en) 2003-08-22 2014-06-10 Medtronic, Inc. Methods of using a prosthesis fixturing device
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
JP2007522829A (en) * 2003-10-02 2007-08-16 エドワーズ ライフサイエンシーズ コーポレイションEdwards Lifesciences Corporation Implantable prosthetic valve with a non-laminar flow
JP2011172969A (en) * 2003-10-02 2011-09-08 Edwards Lifesciences Corp Implantable prosthetic valve with non-laminar flow
JP4852421B2 (en) * 2003-10-02 2012-01-11 エドワーズ ライフサイエンシーズ コーポレイションEdwards Lifesciences Corporation Implantable prosthetic valve with a non-laminar flow
US8080054B2 (en) 2003-10-02 2011-12-20 Edwards Lifesciences Corporation Implantable prosthetic valve with non-laminar flow
US9241793B2 (en) 2003-10-02 2016-01-26 Edwards Lifesciences Corporation Method of implanting a prosthetic aortic valve having non-laminar flow
US9956075B2 (en) 2003-12-23 2018-05-01 Boston Scientific Scimed Inc. Methods and apparatus for endovascularly replacing a heart valve
US9585750B2 (en) 2003-12-23 2017-03-07 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9393113B2 (en) 2003-12-23 2016-07-19 Boston Scientific Scimed Inc. Retrievable heart valve anchor and method
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9358106B2 (en) 2003-12-23 2016-06-07 Boston Scientific Scimed Inc. Methods and apparatus for performing valvuloplasty
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US9585749B2 (en) 2003-12-23 2017-03-07 Boston Scientific Scimed, Inc. Replacement heart valve assembly
US8858620B2 (en) 2003-12-23 2014-10-14 Sadra Medical Inc. Methods and apparatus for endovascularly replacing a heart valve
US8231670B2 (en) 2003-12-23 2012-07-31 Sadra Medical, Inc. Repositionable heart valve and method
US8894703B2 (en) 2003-12-23 2014-11-25 Sadra Medical, Inc. Systems and methods for delivering a medical implant
WO2005070343A1 (en) * 2003-12-23 2005-08-04 Laboratoires Perouse Kit which is intended to be implanted in a conduit
US8840662B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve and method
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US8623076B2 (en) 2003-12-23 2014-01-07 Sadra Medical, Inc. Low profile heart valve and delivery system
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US8246675B2 (en) 2003-12-23 2012-08-21 Laboratoires Perouse Kit for implanting in a duct
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US9861476B2 (en) 2003-12-23 2018-01-09 Boston Scientific Scimed Inc. Leaflet engagement elements and methods for use thereof
US8246678B2 (en) 2003-12-23 2012-08-21 Sadra Medicl, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US9277991B2 (en) 2003-12-23 2016-03-08 Boston Scientific Scimed, Inc. Low profile heart valve and delivery system
US8623078B2 (en) 2003-12-23 2014-01-07 Sadra Medical, Inc. Replacement valve and anchor
US9872768B2 (en) 2003-12-23 2018-01-23 Boston Scientific Scimed, Inc. Medical devices and delivery systems for delivering medical devices
US9308085B2 (en) 2003-12-23 2016-04-12 Boston Scientific Scimed, Inc. Repositionable heart valve and method
US9358110B2 (en) 2003-12-23 2016-06-07 Boston Scientific Scimed, Inc. Medical devices and delivery systems for delivering medical devices
US9011521B2 (en) 2003-12-23 2015-04-21 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8252052B2 (en) 2003-12-23 2012-08-28 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9532872B2 (en) 2003-12-23 2017-01-03 Boston Scientific Scimed, Inc. Systems and methods for delivering a medical implant
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
DE10394350B4 (en) 2003-12-23 2018-05-17 Cormove Into a lumen to be implanted prosthesis kit of parts and containing the same
US9320599B2 (en) 2003-12-23 2016-04-26 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a heart valve
US9867695B2 (en) 2004-03-03 2018-01-16 Sorin Group Italia S.R.L. Minimally-invasive cardiac-valve prosthesis
US8109996B2 (en) 2004-03-03 2012-02-07 Sorin Biomedica Cardio, S.R.L. Minimally-invasive cardiac-valve prosthesis
US8535373B2 (en) 2004-03-03 2013-09-17 Sorin Group Italia S.R.L. Minimally-invasive cardiac-valve prosthesis
US8992608B2 (en) 2004-06-16 2015-03-31 Sadra Medical, Inc. Everting heart valve
US8668733B2 (en) 2004-06-16 2014-03-11 Sadra Medical, Inc. Everting heart valve
US9744035B2 (en) 2004-06-16 2017-08-29 Boston Scientific Scimed, Inc. Everting heart valve
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US8617236B2 (en) 2004-11-05 2013-12-31 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
US8328868B2 (en) 2004-11-05 2012-12-11 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
US8562672B2 (en) 2004-11-19 2013-10-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
US9498329B2 (en) 2004-11-19 2016-11-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
US7857845B2 (en) 2005-02-10 2010-12-28 Sorin Biomedica Cardio S.R.L. Cardiac-valve prosthesis
US8539662B2 (en) 2005-02-10 2013-09-24 Sorin Group Italia S.R.L. Cardiac-valve prosthesis
US9486313B2 (en) 2005-02-10 2016-11-08 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US8540768B2 (en) 2005-02-10 2013-09-24 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US9895223B2 (en) 2005-02-10 2018-02-20 Sorin Group Italia S.R.L. Cardiac valve prosthesis
EP2319458A1 (en) 2005-02-10 2011-05-11 Sorin Biomedica Cardio S.r.l. Cardiac-valve prosthesis
US8920492B2 (en) 2005-02-10 2014-12-30 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US7927369B2 (en) 2005-03-01 2011-04-19 Leman Cardiovascular Sa Intraparietal reinforcing device for biological cardiac prosthesis and reinforced biological heart valve prosthesis
WO2006106205A3 (en) * 2005-04-05 2006-12-28 Perouse Lab Kit designed to be implanted in a bloodstream duct, and related tubular endoprosthesis
US9408693B2 (en) 2005-04-05 2016-08-09 Cormove Kit which is intended to be implanted in a blood vessel, and associated tubular endoprosthesis
CN101184456B (en) 2005-04-05 2010-09-29 贝鲁斯研制厂 Kit for embedding in blood vessel as well as correlative tubular inner prosthesis
FR2883721A1 (en) * 2005-04-05 2006-10-06 Perouse Soc Par Actions Simpli Vascular endoprosthetic device comprising prosthetic valve implanted in stent, includes variable cross-section pieces forming shoulders to block axial displacement and ensure accurate mounting
US8500802B2 (en) 2005-04-08 2013-08-06 Medtronic, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
US9415225B2 (en) 2005-04-25 2016-08-16 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US9649495B2 (en) 2005-04-25 2017-05-16 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
US9504564B2 (en) 2005-05-13 2016-11-29 Medtronic Corevalve Llc Heart valve prosthesis and methods of manufacture and use
USD812226S1 (en) 2005-05-13 2018-03-06 Medtronic Corevalve Llc Heart valve prosthesis
US9060857B2 (en) 2005-05-13 2015-06-23 Medtronic Corevalve Llc Heart valve prosthesis and methods of manufacture and use
USD732666S1 (en) 2005-05-13 2015-06-23 Medtronic Corevalve, Inc. Heart valve prosthesis
JP2008539985A (en) * 2005-05-13 2008-11-20 コアヴァルヴ,インコーポレイテッド Prosthetic heart valves as well as methods of making and using the same
US9907651B2 (en) 2005-06-13 2018-03-06 Edwards Lifesciences Corporation Delivery system for a prosthetic heart valve
US9028545B2 (en) 2005-06-13 2015-05-12 Edwards Lifesciences Corporation Method of delivering a prosthetic heart valve
US8506620B2 (en) 2005-09-26 2013-08-13 Medtronic, Inc. Prosthetic cardiac and venous valves
US9539092B2 (en) 2005-10-18 2017-01-10 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US9839514B2 (en) 2005-10-18 2017-12-12 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US9078781B2 (en) 2006-01-11 2015-07-14 Medtronic, Inc. Sterile cover for compressible stents used in percutaneous device delivery systems
US9331328B2 (en) 2006-03-28 2016-05-03 Medtronic, Inc. Prosthetic cardiac valve from pericardium material and methods of making same
US8075615B2 (en) 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US10058421B2 (en) 2006-03-28 2018-08-28 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
EP1849440A1 (en) * 2006-04-28 2007-10-31 Younes Boudjemline Vascular stents with varying diameter
US8821569B2 (en) 2006-04-29 2014-09-02 Medtronic, Inc. Multiple component prosthetic heart valve assemblies and methods for delivering them
US8747460B2 (en) 2006-09-19 2014-06-10 Medtronic Ventor Technologies Ltd. Methods for implanting a valve prothesis
US8771345B2 (en) 2006-09-19 2014-07-08 Medtronic Ventor Technologies Ltd. Valve prosthesis fixation techniques using sandwiching
US8771346B2 (en) 2006-09-19 2014-07-08 Medtronic Ventor Technologies Ltd. Valve prosthetic fixation techniques using sandwiching
US8876894B2 (en) 2006-09-19 2014-11-04 Medtronic Ventor Technologies Ltd. Leaflet-sensitive valve fixation member
US8348995B2 (en) 2006-09-19 2013-01-08 Medtronic Ventor Technologies, Ltd. Axial-force fixation member for valve
US8348996B2 (en) 2006-09-19 2013-01-08 Medtronic Ventor Technologies Ltd. Valve prosthesis implantation techniques
US8052750B2 (en) 2006-09-19 2011-11-08 Medtronic Ventor Technologies Ltd Valve prosthesis fixation techniques using sandwiching
US9138312B2 (en) 2006-09-19 2015-09-22 Medtronic Ventor Technologies Ltd. Valve prostheses
US9642704B2 (en) 2006-09-19 2017-05-09 Medtronic Ventor Technologies Ltd. Catheter for implanting a valve prosthesis
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US10004601B2 (en) 2006-09-19 2018-06-26 Medtronic Ventor Technologies Ltd. Valve prosthesis fixation techniques using sandwiching
US8414643B2 (en) 2006-09-19 2013-04-09 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
US8876895B2 (en) 2006-09-19 2014-11-04 Medtronic Ventor Technologies Ltd. Valve fixation member having engagement arms
US8470024B2 (en) 2006-12-19 2013-06-25 Sorin Group Italia S.R.L. Device for in situ positioning of cardiac valve prosthesis
US7993392B2 (en) 2006-12-19 2011-08-09 Sorin Biomedica Cardio S.R.L. Instrument and method for in situ deployment of cardiac valve prostheses
US8070799B2 (en) 2006-12-19 2011-12-06 Sorin Biomedica Cardio S.R.L. Instrument and method for in situ deployment of cardiac valve prostheses
US9056008B2 (en) 2006-12-19 2015-06-16 Sorin Group Italia S.R.L. Instrument and method for in situ development of cardiac valve prostheses
US8057539B2 (en) 2006-12-19 2011-11-15 Sorin Biomedica Cardio S.R.L. System for in situ positioning of cardiac valve prostheses without occluding blood flow
US9114008B2 (en) 2006-12-22 2015-08-25 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method for making the same
US7871436B2 (en) 2007-02-16 2011-01-18 Medtronic, Inc. Replacement prosthetic heart valves and methods of implantation
US7785364B2 (en) 2007-06-08 2010-08-31 Laboratoires Perouse Kit to be implanted in a blood circulation conduit
EP2000116A1 (en) 2007-06-08 2008-12-10 Laboratoires perouse Kit designed to be implanted in a blood vessel
US7815677B2 (en) 2007-07-09 2010-10-19 Leman Cardiovascular Sa Reinforcement device for a biological valve and reinforced biological valve
US8808367B2 (en) 2007-09-07 2014-08-19 Sorin Group Italia S.R.L. Prosthetic valve delivery system including retrograde/antegrade approach
US8475521B2 (en) 2007-09-07 2013-07-02 Sorin Group Italia S.R.L. Streamlined delivery system for in situ deployment of cardiac valve prostheses
US8486137B2 (en) 2007-09-07 2013-07-16 Sorin Group Italia S.R.L. Streamlined, apical delivery system for in situ deployment of cardiac valve prostheses
US8114154B2 (en) 2007-09-07 2012-02-14 Sorin Biomedica Cardio S.R.L. Fluid-filled delivery system for in situ deployment of cardiac valve prostheses
US9078749B2 (en) 2007-09-13 2015-07-14 Georg Lutter Truncated cone heart valve stent
US9095433B2 (en) 2007-09-13 2015-08-04 Georg Lutter Truncated cone heart valve stent
US9254192B2 (en) 2007-09-13 2016-02-09 Georg Lutter Truncated cone heart valve stent
US9351828B2 (en) 2007-09-26 2016-05-31 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US8425593B2 (en) 2007-09-26 2013-04-23 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9549815B2 (en) 2007-09-26 2017-01-24 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9545307B2 (en) 2007-09-26 2017-01-17 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9345571B1 (en) 2007-09-26 2016-05-24 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9636221B2 (en) 2007-09-26 2017-05-02 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US8845721B2 (en) 2007-09-26 2014-09-30 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9241794B2 (en) 2007-09-26 2016-01-26 St. Jude Medical, Inc. Collapsible prosthetic heart valves
US9693859B2 (en) 2007-09-26 2017-07-04 St. Jude Medical, Llc Collapsible prosthetic heart valves
US9532868B2 (en) 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US9289290B2 (en) 2007-09-28 2016-03-22 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US9820851B2 (en) 2007-09-28 2017-11-21 St. Jude Medical, Llc Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US9364321B2 (en) 2007-09-28 2016-06-14 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US8784481B2 (en) 2007-09-28 2014-07-22 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US9615921B2 (en) 2007-09-28 2017-04-11 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
US9510942B2 (en) 2007-12-14 2016-12-06 Edwards Lifesciences Corporation Leaflet attachment frame for a prosthetic valve
US9333100B2 (en) 2008-01-24 2016-05-10 Medtronic, Inc. Stents for prosthetic heart valves
US8628566B2 (en) 2008-01-24 2014-01-14 Medtronic, Inc. Stents for prosthetic heart valves
US9089422B2 (en) 2008-01-24 2015-07-28 Medtronic, Inc. Markers for prosthetic heart valves
US10076412B2 (en) 2008-02-29 2018-09-18 Edwards Lifesciences Corporation Expandable member for deploying a prosthetic device
US9241792B2 (en) 2008-02-29 2016-01-26 Edwards Lifesciences Corporation Two-step heart valve implantation
US8784480B2 (en) 2008-02-29 2014-07-22 Edwards Lifesciences Corporation Expandable member for deploying a prosthetic device
US9592120B2 (en) 2008-03-18 2017-03-14 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8511244B2 (en) 2008-04-23 2013-08-20 Medtronic, Inc. Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US8696743B2 (en) 2008-04-23 2014-04-15 Medtronic, Inc. Tissue attachment devices and methods for prosthetic heart valves
US8312825B2 (en) 2008-04-23 2012-11-20 Medtronic, Inc. Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US9061119B2 (en) 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
US8840661B2 (en) 2008-05-16 2014-09-23 Sorin Group Italia S.R.L. Atraumatic prosthetic heart valve prosthesis
US9662204B2 (en) 2008-06-06 2017-05-30 Edwards Lifesciences Corporation Low profile transcatheter heart valve
US7993394B2 (en) 2008-06-06 2011-08-09 Ilia Hariton Low profile transcatheter heart valve
US8454685B2 (en) 2008-06-06 2013-06-04 Edwards Lifesciences Corporation Low profile transcatheter heart valve
US8236049B2 (en) 2008-06-20 2012-08-07 Edwards Lifesciences Corporation Multipiece prosthetic mitral valve and method
US9561101B2 (en) 2008-06-20 2017-02-07 Edwards Lifesciences Corporation Two-part prosthetic valve system
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
US9993338B2 (en) 2008-06-20 2018-06-12 Edwards Lifesciences Corporation Methods for retaining a prosthetic heart valve
US9351831B2 (en) 2008-07-15 2016-05-31 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9351832B2 (en) 2008-07-15 2016-05-31 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9220594B2 (en) 2008-07-15 2015-12-29 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9289296B2 (en) 2008-07-15 2016-03-22 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9681949B2 (en) 2008-07-15 2017-06-20 St. Jude Medical, Llc Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US10010410B2 (en) 2008-07-15 2018-07-03 St. Jude Medical, Llc Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US9675449B2 (en) 2008-07-15 2017-06-13 St. Jude Medical, Llc Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US8808356B2 (en) 2008-07-15 2014-08-19 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US9364325B2 (en) 2008-08-22 2016-06-14 Edwards Lifesciences Corporation Prosthetic heart valve delivery system and method
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
US9532873B2 (en) 2008-09-17 2017-01-03 Medtronic CV Luxembourg S.a.r.l. Methods for deployment of medical devices
US9301840B2 (en) 2008-10-10 2016-04-05 Edwards Lifesciences Corporation Expandable introducer sheath
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
US8834563B2 (en) 2008-12-23 2014-09-16 Sorin Group Italia S.R.L. Expandable prosthetic valve having anchoring appendages
US8252051B2 (en) 2009-02-25 2012-08-28 Edwards Lifesciences Corporation Method of implanting a prosthetic valve in a mitral valve with pulmonary vein anchoring
US8512397B2 (en) 2009-04-27 2013-08-20 Sorin Group Italia S.R.L. Prosthetic vascular conduit
US8403982B2 (en) 2009-05-13 2013-03-26 Sorin Group Italia S.R.L. Device for the in situ delivery of heart valves
US9168105B2 (en) 2009-05-13 2015-10-27 Sorin Group Italia S.R.L. Device for surgical interventions
US8353953B2 (en) 2009-05-13 2013-01-15 Sorin Biomedica Cardio, S.R.L. Device for the in situ delivery of heart valves
US9717594B2 (en) 2009-07-14 2017-08-01 Edwards Lifesciences Corporation Methods of valve delivery on a beating heart
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
US8926691B2 (en) 2009-12-04 2015-01-06 Edwards Lifesciences Corporation Apparatus for treating a mitral valve
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9084676B2 (en) 2009-12-04 2015-07-21 Edwards Lifesciences Corporation Apparatus for treating a mitral valve
US8986373B2 (en) 2009-12-04 2015-03-24 Edwards Lifesciences Corporation Method for implanting a prosthetic mitral valve
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
US8652204B2 (en) 2010-04-01 2014-02-18 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
US9925044B2 (en) 2010-04-01 2018-03-27 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
US9248017B2 (en) 2010-05-21 2016-02-02 Sorin Group Italia S.R.L. Support device for valve prostheses and corresponding kit
US9795476B2 (en) 2010-06-17 2017-10-24 St. Jude Medical, Llc Collapsible heart valve with angled frame
US9375312B2 (en) 2010-07-09 2016-06-28 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US9931206B2 (en) 2010-07-09 2018-04-03 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US9326853B2 (en) 2010-07-23 2016-05-03 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US8814931B2 (en) 2010-08-24 2014-08-26 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery systems
US9039759B2 (en) 2010-08-24 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
US9545308B2 (en) 2010-08-24 2017-01-17 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery systems
US9615924B2 (en) 2010-09-17 2017-04-11 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery
US8778019B2 (en) 2010-09-17 2014-07-15 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and method for transcatheter heart valve delivery
USD660432S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Commissure point
USD684692S1 (en) 2010-09-20 2013-06-18 St. Jude Medical, Inc. Forked ends
US9011527B2 (en) 2010-09-20 2015-04-21 St. Jude Medical, Cardiology Division, Inc. Valve leaflet attachment in collapsible prosthetic valves
USD654169S1 (en) 2010-09-20 2012-02-14 St. Jude Medical Inc. Forked ends
USD653341S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical stent
USD653342S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Stent connections
USD648854S1 (en) 2010-09-20 2011-11-15 St. Jude Medical, Inc. Commissure points
USD652926S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Forked end
USD660967S1 (en) 2010-09-20 2012-05-29 St. Jude Medical, Inc. Surgical stent
US9827091B2 (en) 2010-09-20 2017-11-28 St. Jude Medical, Cardiology Division, Inc. Valve leaflet attachment in collapsible prosthetic valves
USD654170S1 (en) 2010-09-20 2012-02-14 St. Jude Medical, Inc. Stent connections
USD660433S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Surgical stent assembly
USD652927S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Surgical stent
USD653343S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical cuff
US8568475B2 (en) 2010-10-05 2013-10-29 Edwards Lifesciences Corporation Spiraled commissure attachment for prosthetic valve
US9393110B2 (en) 2010-10-05 2016-07-19 Edwards Lifesciences Corporation Prosthetic heart valve
US9005279B2 (en) 2010-11-12 2015-04-14 Shlomo Gabbay Beating heart buttress and implantation method to prevent prolapse of a heart valve
US9775707B2 (en) 2011-02-01 2017-10-03 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
US9545309B2 (en) 2011-02-01 2017-01-17 St. Jude Medical, Cardiology Divisions, Inc. Repositioning of prosthetic heart valve and deployment
US9289289B2 (en) 2011-02-14 2016-03-22 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US9161836B2 (en) 2011-02-14 2015-10-20 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US10058313B2 (en) 2011-05-24 2018-08-28 Sorin Group Italia S.R.L. Transapical valve replacement
US9289282B2 (en) 2011-05-31 2016-03-22 Edwards Lifesciences Corporation System and method for treating valve insufficiency or vessel dilatation
US9999506B2 (en) 2011-05-31 2018-06-19 Edwards Lifesciences Corporation System and method for treating valve insufficiency or vessel dilatation
US8998976B2 (en) 2011-07-12 2015-04-07 Boston Scientific Scimed, Inc. Coupling system for medical devices
US9119716B2 (en) 2011-07-27 2015-09-01 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US9795477B2 (en) 2011-07-27 2017-10-24 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US9339384B2 (en) 2011-07-27 2016-05-17 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US9867701B2 (en) 2011-08-18 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Devices and methods for transcatheter heart valve delivery
US9370421B2 (en) 2011-12-03 2016-06-21 Boston Scientific Scimed, Inc. Medical device handle
US9757229B2 (en) 2011-12-09 2017-09-12 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
US9168131B2 (en) 2011-12-09 2015-10-27 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
US9138314B2 (en) 2011-12-29 2015-09-22 Sorin Group Italia S.R.L. Prosthetic vascular conduit and assembly method
US8685084B2 (en) 2011-12-29 2014-04-01 Sorin Group Italia S.R.L. Prosthetic vascular conduit and assembly method
US9289292B2 (en) 2012-06-28 2016-03-22 St. Jude Medical, Cardiology Division, Inc. Valve cuff support
US9554902B2 (en) 2012-06-28 2017-01-31 St. Jude Medical, Cardiology Division, Inc. Leaflet in configuration for function in various shapes and sizes
US9241791B2 (en) 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
US9615920B2 (en) 2012-06-29 2017-04-11 St. Jude Medical, Cardiology Divisions, Inc. Commissure attachment feature for prosthetic heart valve
US9895218B2 (en) 2012-06-29 2018-02-20 St. Jude Medical, Cardiology Division, Inc. Commissure attachment feature for prosthetic heart valve
US9808342B2 (en) 2012-07-03 2017-11-07 St. Jude Medical, Cardiology Division, Inc. Balloon sizing device and method of positioning a prosthetic heart valve
US10004597B2 (en) 2012-07-03 2018-06-26 St. Jude Medical, Cardiology Division, Inc. Stent and implantable valve incorporating same
US9907652B2 (en) 2012-09-06 2018-03-06 Edwards Lifesciences Corporation Heart valve sealing devices
US9510946B2 (en) 2012-09-06 2016-12-06 Edwards Lifesciences Corporation Heart valve sealing devices
US9414918B2 (en) 2012-09-06 2016-08-16 Edwards Lifesciences Corporation Heart valve sealing devices
US9801721B2 (en) 2012-10-12 2017-10-31 St. Jude Medical, Cardiology Division, Inc. Sizing device and method of positioning a prosthetic heart valve
US10016276B2 (en) 2012-11-21 2018-07-10 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic heart valves
US9186238B2 (en) 2013-01-29 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Aortic great vessel protection
US9655719B2 (en) 2013-01-29 2017-05-23 St. Jude Medical, Cardiology Division, Inc. Surgical heart valve flexible stent frame stiffener
US9962252B2 (en) 2013-01-29 2018-05-08 St. Jude Medical, Cardiology Division, Inc. Aortic great vessel protection
US9314163B2 (en) 2013-01-29 2016-04-19 St. Jude Medical, Cardiology Division, Inc. Tissue sensing device for sutureless valve selection
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9168129B2 (en) 2013-02-12 2015-10-27 Edwards Lifesciences Corporation Artificial heart valve with scalloped frame design
US9844435B2 (en) 2013-03-01 2017-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve replacement
US9901470B2 (en) 2013-03-01 2018-02-27 St. Jude Medical, Cardiology Division, Inc. Methods of repositioning a transcatheter heart valve after full deployment
US9480563B2 (en) 2013-03-08 2016-11-01 St. Jude Medical, Cardiology Division, Inc. Valve holder with leaflet protection
US10028829B2 (en) 2013-03-08 2018-07-24 St. Jude Medical, Cardiology Division, Inc. Valve holder with leaflet protection
US9687341B2 (en) 2013-03-12 2017-06-27 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US9867697B2 (en) 2013-03-12 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for a paravalvular leak protection
US9636222B2 (en) 2013-03-12 2017-05-02 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak protection
US9339274B2 (en) 2013-03-12 2016-05-17 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
US9398951B2 (en) 2013-03-12 2016-07-26 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensu