US3874388A - Shunt defect closure system - Google Patents

Shunt defect closure system Download PDF

Info

Publication number
US3874388A
US3874388A US33155973A US3874388A US 3874388 A US3874388 A US 3874388A US 33155973 A US33155973 A US 33155973A US 3874388 A US3874388 A US 3874388A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
umbrella
structure
shunt
means
defect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Terry D King
Noel L Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ochsner Alton Medical Foundation
Original Assignee
Ochsner Alton Medical Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00588Rigid or stiff implements, e.g. made of several rigid parts linked by hinges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00606Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00619Locking means for locking the implement in expanded state

Abstract

A method and apparatus for closing off a septal defect or shunt in the intravascular system or the great vessels including a pair of opposed, umbrella-like elements locked together in face-toface relationship on opposite sides of the septal defect, thereby closing it. The dual umbrella-like closure elements are sequentially applied and joined together via an outer catheter inserted into the interior of the heart by means of the jugular vein in the neck or a vein in the groin along with other associated operative elements used within the outer catheter, thereby eliminating the need for open-heart surgery to correct a septal defect or shunt as was heretofore required. For a ventricular septal defect a single umbrella-like element is used which is temporarily held in place by an operative element which is subsequently removed.

Description

United States Patent [191 King et al.

[ SHUNT DEFECT CLOSURE SYSTEM [75] Inventors: Terry D. King; Noel L. Mills, both of New Orleans, La.

[73] Assignee: Alton Oehsner Medical Foundation,

New Orleans, La.

22 Filed: Feb. 12, 1973 211 App1.No,:331,559

[52] U.S. Cl. 128/334 R, 128/334 C [51] Int. Cl A6lb 17/04 [58] Field of Search 128/334 R, 335, 348, 351,

OTHER PUBLICATIONS Hunter et al., Annals of Surgery February 1970, Vol. 171, No. 2, pp. 315-320.

[ Apr. 1, 1975 King et al., Surgery December 1953, Vol. 34, pp. 1 100-1116.

Primary Examiner-Dalton L. Truluck Attorney, Agent, or Firm-Pugh & Laiche [57] ABSTRACT A method and apparatus for closing off a septal defect or shunt in the intravascular system or the great vessels including apair of opposed, umbrella-like elements locked together in face-to-face relationship on opposite sides of the septal defect, thereby closing it. The dual umbrella-like closure elements are sequentially applied and joined together via an outer catheter inserted into the interior of the heart by means of the jugular vein in the neck or a vein in the groin along with other associated operative elements used within the outer catheter, thereby eliminating the need for open-heart surgery to correct a septal defect or shunt as was heretofore required. For a ventricular septal defect at single umbrella-like element is used which is temporarily held in place by an operative element which is subsequently removed.

30 Claims, 40 Drawing Figures FEJEN TED APR 1 19. 5

SHEEI [ilJF 1O FIG. IB.

PATENIEDAPR H975 FIG. 3C.

FIG.4.

PATENTEDAPR' 1 1975 SHEET DSOF1O ATENTED R 1 ms 3, 874.388 SHEEI U70F 1O FIG. IOA. FIG. IOB.

PATENTEU 1 1 5 SHEET CBUF 10 FIG. I2A.

PATENTEU H915 3.874.388

SHEET CBUF 1O FIG. I! 0. FIG. I3A.

FIG. l3 0.

PATENIMHR' a M315 1 874. 388 saw 10 a; w

SHUNT DEFECT CLOSURE SYSTEM BACKGROUND OF THE INVENTION l. Field of the Invention The present invention relates to an intravascular method and apparatus for closure of septal defects or shunts in the intravascular system or the great vessels by means of a positive mechanical structure applied by means of an outer catheter and other associated operative elements working within said outer catheter.

2. General Background In order to gain a better understanding of the present invention and its particular application, it is noted that the heart is divided into four compartments or chambers, the two upper being the left and right atria and the two lower being the left and right ventricles. The atria are separated from each other by a muscular wall, the interatrial septum, and the vertrucles by the interventricular septum.

Either congenitally or by acquisition, abnormal openings, holes or shunts can occur between the chambers of the heart or the great vessels (interatrial and interventricular septal defects or patent ductus arteriosus and aorthico-pulmonary window respectively), causing shunting of blood through the opening. The deformity is usually congenital, resulting from a failure of completion of the formation of the septum, or wall, between the two sides during fetal life when the heart forms from a folded tube into a four-chambered, two unit system.

These deformities can carry significant sequelae. For example. with an atrial septal defect, blood is shunted from the left atrium of the heart to the right, producing an over-load of the right heart. In addition to left-toright shunts such as occur in patent ductus arteriousus from the aorta to the pulmonary artery, the left side of the heart has to work harder because some of the blood which it pumps will recirculate through the lungs instead of going out to the rest of the body. The ill effects of these lesions usually cause added strain on the heart with ultimate heart failure if not corrected.

GENERAL DISCUSSION OF PRIOR ART AND PRESENT INVENTION Heretofore these intracardiac or extracardiac septal defects have required relatively extensive surgical techniques for correction. In I938 surgeons first seriously entered the field of attacking congenital heart disease when Gross reported the first ligation of a patent ductus arteriosus. Since that time rapid advances have allowed thoracic surgeons to close not only extracardiac congenital shunts but also shunts between the chambers of the heart. The modern era of extracorporeal circulation began in 1953 when Gibbon first closed an atrial-septal defect, using the heart-lung machine. To date the present method of closing intracardiac shunts, such as atrial-septal defects and ventricular-septal defects, entails the relatively drastic technique of openheart surgery, requiring opening the chest or sternum and diverting the blood from the heart with the use of a cardiopulmonary bypass. The heart is then opened, the defect is sewn shut by direct suturing with or without a patch of synthetic material (usually of Dacron, Teflon, silk, nylon or pericardium), and the heart closed. The patient is then taken off the cardiopulmonary bypass machine, and the chest closed.

In place of direct suturing, it has been suggested that closures of interauricular septal defects could be made by means of a double button" prosthesis, but open heart surgery was still required. See for example Closure of Interauricular Septal Defects by Charles A. Hufnagel, et al., The Bulletin Georgetown University Medical Center, Vol. IV, No. 5, Pp. 137-139, Feb.- Mar.. 1951', which also cited Swan H.: Experimental Closure of lnterauricular Septal Defects Symposium of Cardiovascular Research, National Institute of Health, Jan. 2|, 1950, Washington, DC. Additional work with such a button-type prothesis in open heart surgery was also apparently done by CR Bailey, M.D. (see Bailey, et al.: Correction of lnterventricular Septal Defects," Am. Surgery, 136, 919, 1952; and Bailey: Surgery of the Heart, Lea and Febiger, Philadelphia, Pp. 366,1955) and by Yousif D. Al-Naaman, M.D., Department ofThoracic and Cardiovascular Surgery, University of Baghdad, Iraq.

Thus, prior to the present invention, it was only possible to repair septal defects or shunts through openheart surgery, involving shunting the blood through an artificial pump-oxygenator (heart-lung machine) or at least supplanting the action of the heart itself (mechanical heart) while the heart is being repaired. Moreover, although excellent results have been obtained on simple septal defects by open-heart surgery, there is great risk in open-heart surgery in patients whose heart muscles have been under great strain for long periods of time.

In contrast to the relatively drastic technique of open-heart surgery, the system of the present invention closes off septal defects or shunts without the need of general anesthesia or opening of the chest. Instead the operative techniques employed in the present invention require only a small incision over a vein in the groin or neck under only local anesthesia, such as is carried out for many routine cardiac catheterizations.

Moreover, the catheter/closure system of the present invention allows a cardiologist to close a septal defect at the time of diagnostic cardiac catheterization, if desired. Because of the proposed size of the outer catheter used in the present invention, this would be most reasonably carried out after the age of 4 to 5 years.

In addition to a far superior, less drastic surgical procedure, the present invention achieves this by means of a unique, permanent catheter/closure system utilizing an expandible catheter/closure structure formed by relatively inexpensive, positive mechanical elements which are relatively simple and reliable in structure and made of readily available and proven materials. In the preferred embodiment of the present invention the catheter/closure structure includes either a single expandible umbrella-like element or an opposed pair of expandible umbrella-like elements, depending on the location of the septal defect.

It is noted that the term catheter" as used herein refers to an instrument, generally tubular in shape, which is inserted into a body cavity, naturally or surgically opened. Several different catheters have been developed in the past, either for experimental research purposes or clinical application. The Mobin-Uddin catheter is one that is used for partial occlusion of the inferior vena cava to prevent pulmonary embolization. This catheter has been described in a publication by Drs. Kazi Mobin-Uddin and James R. Jude in an article entitled A New Catheter Technique of Interruption of the Inferior Vena Cava for Prevention of Pulmonary Embolism," The American Surgeon, Volume 35, page 889, December I969. See also US. Pat. No. 3,540,43l to Dr. Kazi Mobin-Uddin issued Nov. l7, I970. A similar catheter technique, but using a balloon obstruction instead of an umbrella-type obstruction, is disclosed in the article Experimental Balloon Obstruction of the Inferior Vena Cava" by Hunter, et al., Annals of Surgery, Vol. 171, No. 3, Pp. 3l5-320, February I970.

Additionally, in experimental work performed by one lines; while of the co-inventors hereof, a cardiac catheter with an FIGS. 23 and 2C are side, cross-sectional and end inflatable disc balloon for interim closure of Ieft-toviews, respectively, ofthe inner, central hub of the left right shunts through the ventricular septum was used. umbrella-like closure element of FIG. 2A;

This catheter has been described in a publication by FIG. 3A is a side view of the right umbrella-like clo- Dr. Noel L. Mills, et al., In an article entitled Balloon l5 sure element of the present invention in its collapsed Closure of Ventricular Septal Defect, .Supplememlto p i i with th i t l lidi g sleeve shown Circulation, VOIS. XLIII and XLIV, page I-l I I, May partially in phantgm lines; while I971. See also th article y Harold mg t t. n- FIGS. 38 and 3C are side, cross-sectional and end titled Experimental Surg|cal Repair of en r cula views, respectively, of the inner, central sliding sleeve Sepml Defects. SURGERY, Vol- 34. PP- H of the right umbrella-like closure element of FIG. 3A; l.l l Detlembef. 1953- FIG. 4 is a side view of a typical strut element used f examples Ofother expfmdlble and/01' in the left and right umbrella-like closure elements of la-ltke elements generally used in other types of surgih present invention; cal applications are found In the following US. Patents: HQ 5 i a perspective View f three f h catheter Patent No. Inventor(s) Title Issue Date 2,493,326 .I. H. Trinder Tampon For Control l/3U/50 of Intractable Nasal Hemorrhages 2,799,273 v. I. Oddo Hacmostatic Catheter" 7/ l6/57 3,334,629 8. D. Cohn "Occulsivc Device 8/8/67 For Inferior Vena 3.397.699 G. C. Kohl "Retaining Catheter 8/20/68 Havin Rcsiliently Biase Wing Flanges 3.S92,l84 David H. Watkins "Heart Assist Method 7/I3/7l Erwin J. Klink And Catheter" 3,671,979 Spyridon Catheter Mounted 6/27/72 Artificial Heart Valve For lm lanting In Close roximtty To A Defective Natural Heart Valve However, as should be fully appreciated and underp ativ elements, concentrically assembled together, stood from the detailed description of the preferred which are used in the method of the present invention; embodiments below, all of these diverse prior art cathe- FIG. 6 is a side, perspective view, partially cut away, ters and umbrella-like elements, neither collectively 0f the catheter operative elements with the left umbrelnor individually, anticipate or make obvious the presla-Iike closure element attached to the central one with em, pioneering and far-reaching invention. the struts thereof partially opened, portions of the umbrella-ltke element, particularly the covering material, not being illustrated for simplicity purposes; while BRIEF DESCRIPTION OF THI I DRAWINGS FIG. 7 IS similar to FIG. 6 with the exception of showmg the right umbrella-like closure element being af- I I fixed to the central one of the catheter operative ele- For a further understanding of the nature and objects ments and showing an additional operative element, a of the present n t n. r fer n e Should be had to the control disc, positioned on the proximal end ofthe cenfollowmg detailed description, taken in con unctlon 1 th operative element. with the accompanying dra ng m which like parts FIG. 8 is a side view of the cone operative element are given l ke reference numerals and wh rein: used in the method of the present invention to initially FIG- 1A 1s a c ema i Illustration of the heart. P close the umbrella-like elements prior to their insertion tially cut away, showing theapplied closure structure int the outer catheter operative element; of the present invention closing off an atrial septal de- FIGS. 9A through 9K are side, schematic views of the feet with two of the catheter operative elements of the catheter/closure system of the present invention being withdrawn; while inner heart structure illustrating the sequential steps of the method of the present invention as being applied to the closing of an atrial septal defect (ASD); while FIGS. III/\ and lllll are right and left end views. re.- spectively. ol' the umbrella-like closure, eletnents ol' the present invention after being applied and locked together to close off the artrial septal delcct'.

FIG. II is a side. cross-sectional view of the central hub and sleeve structures of the left and right umbrellalike closure elements locked together in a male-female relationship;

FIGS. 12A and IZB are side. cross-sectional and side. perspective views. respectively. of two other structures allowing two other alternative methods of opening or ercctittg the umbrella-like structure of the right umbrella-like closure element;

FIG. ISA is a schematic illustration of the heart. partially cut away. showing the applied closure structure ol the present invention closing oll'a ventricular septal defect with an alternate method utilizing a single umbrella-like element being used; while FIG. IJB is similar in perspective to FIG. 13A showing a typical ventricular septal defect (VSD) prior to the application of the present invention.

FIG. IM is a perspective view otthe single umbrellalike closure element used for a VSI) in its open or erected position; while FIG. [3D is a side view of the special obturator wire used in the alternative single umbrella technique;

FIG. HA is a schematic illustration of the heart. partially cut away. showing the applied closure structure of the present invention closing ol'l'a patent ductus arteriosus (IDAI using a modified right or second um-.

breIla-like closure element with the final catheter operative element of the catheter/closure system of the present invention ready to be withdrawn. while FIG. 14B is similar in perspective to FIG. MA showing a typical patent ductus arteriosus (PDAl prior to the application of the present invention.

FIG. l-IL is a perspective view of the modified left and right or first and second umbrella-like closure elements used for a FDA in their open or erected positions;

FIG. ISA is a side view of a second basic embodiment of the right umbrella-like element of the present invention shown mounted on the ohturator wire prior to its being applied to the shunt; while FIG. [5B is a side view of the embodiment of FIG. ISA as it is being applied to the shunt and being pushed t it its locking position with the left umbrella-like element; while FIG. ISC is a close-up. side view of the central portions of the umbrella-like closure elements in their final. locked position.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Closure Structure and Operative Elements The closure structure of the present invention must be expandible. fulfilling the special requirement of being a structure which has a first. smaller physical form while it is being inserted through a blood vessel and quite a different. second. larger form when placed in its final location closing and covering the septal defeet or shunt. Additionally it must meet the several stringent mechanical requirements placed upon it. must reliably open at the desired time and place. and must effect a suitably tight closure of the defect or shunt in the heart system for along period of time without any deterioration and without producing any antill wanted sitlc-el'l'ects either on tissue or blood. Matty mechanical systems are conceivable to meet these requirements and a most suitable one has been developed and tested and comprises the preferred structural embodiment of the present invention. which will now for purposes of illustration and disclosure only be described in detail.

The closure structure of the preferred embodiment of the present invention. as illustrated in FIGS. 1C. 2 and 3. comprises a pair of opposed. umbrella-like elements 8. 9. a right element 8 having a central. tapered hub 84 and a second element 9 having a central. sliding sleeve 94.

The two umbrella-like closure elements 8. 9 ol' the preferred embodiment ol the present invention have for example six material supporting struts 8|. 9|. respectively. each (note FIG. 4). Each strut 81. 9I has for example a length ol'$.35 mm. with a angle between the struts 8].. 9i. The struts 81. 91 are made of a radiopaque material (not necessarily metallic). for example stainless steel. which have at the distal ends thereof small projections or barbs 83. 93. respectively. ol for example 0.2 mm. length. which allow anchoring ol' the closure elements 8. 9 into the septum. Three holes are provided along the length of the struts 8|. 9| hinge holes 86'. 96; tie eyes 870.971: for raising or lowering the struts 8|, 9] by means ol'ties or lines 7; and suture eyes 87h. 97b for attaching the umbrella material 82. 92 to the struts 8|. 9|. The tie holes 870. 97a are of sufficient size to allow the ties 7 to slide easily through them.

The struts 81. 91 are attached to the umbrella-like closure elements 8. 9 through a central hub 84 and a sliding sleeve 94, respectively. made of for example stainless steel. The surfaces of the hub 84 and the sleeve 94 are grooved (note FIGS. 2( and 3U in such a manner to allow the struts 81. 9|. respectively. to lie superficially in their surfaces without adding to the exterior bulk of the umbrella-like structures. The struts 81. 91 are movably attached to the hub 84 and sleeve 94 by hinge ring elements 86. 96. respectively. and there are included ring-like strut keepers 87. 97, respectively. to prevent the struts 8], 9l from opening. respectively. beyond Each umbrella-like element 8. 9 is of small enough size to allow it to be placed within the outer. thin wall catheter l within which it is transported during application. as described more fully below.

Thin Dacron. Teflon. nylon. silastic. pericardium or silk. for example. routinely used to be close intercardiac defects in open-heart surgery. can be used for the umbrella sheet material 82, 92. although Dacron and silk are considered preferable. The material 82. 92 should be pliable and of sufficient strength and resiliency to open and close smoothly. Although the ambrella material 82. 92 could be fanfolded between the struts 81. 9|, respectively. it is preferred that instead it be stretched or extended flat over the struts. It thus retains a certain amount of resiliency which further aids in opening the umbrellas 8, 9. The material 82.92 is anchored centrally on the hub 84 and the sliding sleeve 94. respectively between the main body thereof and the strut keepers of 87. 97, respectively. Additionally small holes 87!). 97h are made in the struts 81. 91 so that. for example. Tycron sutures 87b. 97b can be used to secure the umbrella material 82, 92. respectively. distally upon the struts 8t, 91. Additionally, supplemental sutures 870', can be used if desired to further secure the material 82, as the eyes 870 have not been found to be otherwise necessary.

The sliding sleeve 94 and the distal hub 84 are designed to lock securely together in opposed, facing relationship by means of an internal, central, male-female mechanism (note particularly FIG. 11). A typical structure for achieving this is illustrated particularly in FIG. 11 with supplemental reference to FIGS. 28 and 3B. The hub 84 includes a small member 84' projecting inwardly and having a locking plateau 85 on its outer surface. This mates with the female cavity formed within the inner portion 94' of the sleeve 94. The female cavity also includes a locking groove 95 for mating with the plateau 85.

To total external diameter of the hub 84 is for example 3.3 mm., and it has been engineered with grooves 89 so that the struts 81 are recessed within the surface and do not occupy any additional space within the outer catheter 1. The hub 84 is tapered slightly to a rounded, bullet-shape configuration at the distal end to a diameter of for example approximately 0.075 mm. The proximal end of the hub 84 is relatively blunt and has a central threaded orifice 80 for mating with the threaded end 31 of the obturator wire 3, described more fully below. The hub 84 can be for example 3 mm. in length.

Although it has not been found to be necessary, the central sliding sleeve 94 of the right umbrella 9 could have a flared or conical distal end in order to center it automatically with respect to the hub projection 84' as a prelude to sliding up over it and along it to the locked position. The bore 90 of the right sleeve 94 is considerably larger than the diameter of the obturator guide wire 3, described below, to allow for free movement thereon.

The operative elements of the closure catheter system of the preferred embodiment of the present invention comprise several parts: an outer catheter 1; an inner, locking catheter 2; an obturator guide wire 3; a loading cone 4; a manipulating T-piece 5; and a tie retracting and control disc 6 with a series of manipulating ties 7. Note particularly FIGS. 5, 7, 8 and 9.1.

The outer, thin wall catheter l, for example a No. 24 inch French size, is of sufficient length (for example 80-105 cm) to allow its manipulation into the heart area. The outer catheter 1 can be made from thin wall, woven Dacron or preferably polyvinyl material and has a gentle curve at the cardiac end to allow easy manipulation through a septal defect in the cardia area.

As shown in FIG. 5, inside the outer, thin wall catheter 1 is a second, radiopaque, inner catheter 2 which could be for example a No. 5 French size catheter of polyvinyl. It should be of sufficient length (for example 90-1 10 cm.) to protrude from the proximal end of the outer catheter 1 and has a rounded, cone-shape distal hub 21. The inner catheter 2 should be of a size to be quite mobile through the outer catheter l.

Passing through the inner catheter 2 is an obturator guide wire 3 which can be for example 1.1 mm. or less in diameter and have a length of for example 200-350 cm. A removable, proximal T-piece 5 (note FIG. 9]) is used for rotational manipulation of the obturator wire 3. The T-piece is locked to the obturator wire 3 and is easily removable therefrom by means of a locking set screw 51 going through the central hub element 53. For gripping purposes an extention arm 52 is provided.

The cardiac or distal end 31 of the obturator wire 3 is threaded for approximately l mrn. so that it may be screwed and unscrewed into the distal hub 84 of the left closing umbrella 8. The obturator wire 3 should be of sufficient flexibility to allow easy manipulation and can be for example made of a fixed core stainless steel spring material.

As shown in FIG. 7, a control disc 6 is provided for ease in manipulating and controlling the ties or suture lines 7. The disc can be made of stainless steel and is placed on the exterior. proximal portion of the obturator wire when needed. A series of hole pairs 61 are pro vided about the periphery of the disc for holding the ties 7. Although not illustrated, the holes 61 could be numbered or coded to the particular struts involved and an additional pair of holes can be provided for the retracting ties 7'. The ties 7, 7' can be made of for example monofilament nylon or 3-0 silk.

The final operative element is the loading cone 4, illustrated in FIG. 8. The loading cone 4 is provided to assist in the easy loading or insertion of the umbrellalike elements 8, 9 into the outer catheter 1. For example, as shown in FIG. 8, the left umbrella 8 threaded, onto the distal end 31 of the obturator wire 3 and in its open or partially opened position, is first inserted through the loading cone 4 which leads into the outer catheter 1. The cone 4 serves to close the umbrellas 8, 9 making them ofa small enough size for insertion into the outer catheter I.

The distance across the total closure structure from hub tip to sleeve tip once locked in place is only approximately 3.5 mm. The umbrella-like elements can be produced in diameter sizes of for example l0mm., 15 mm., 20 mm., 25 mm., 30 mm., and 35 mm., as desired or needed.

Thus, an effective and reliable embodiment is provided for a typical closure structure and associated operative elements. Of course many, other structures are possible, the variations being practically limitless. For example, rather than dual, opposed umbrellas, a single umbrella could be used as described more fully below with respect to the repair of a ventricular septal defect.

Additionally the means of expanding or opening the umbrella can be easily varied. For example as generally shown in FIG. 12A the struts 91' of the right umbrella can be mechanically forced open by appropriate shoulder and flange elements 97 as the sleeve 94a is pushed and locked into the hub 84. Alternatively, as generally illustrated in FIG. 123, the struts 91" could be made of resilient, flexible material so that the umbrella will inherently or automatically open once it emerges from the outer catheter (note the movement of the phantom lined strut).

An additional, very effective, exemplary embodiment of the right umbrella is shown in FIGS. ISA-C in which the necessity of a tie wire system is eliminated. The umbrella 209 is similar in general structure to the right umbrella 9 except that in place of the tie wire system there is included a set of elevating struts 219' hingedly attached between the regular umbrella struts 291 and the elevating sleeve 294. As shown in FIG. 158, as the elvating sleeve 294' comes into contact with the hub 84, the umbrella becomes erected under the continuing pressure of the inner catheter 2 until it is locked into place as shown in FIG. 15C.

Finally, although an umbrella-type structure is thought to be particularly effective, other expansion systems i.e., the elements which initially have a relatively small size for insertion and positioning and which then expand to a relatively large size when in place, are possible and likewise nearly limitless. For example, in place of the umbrella elements. a balloon(s) or other inflatable structure(s) could be used.

Typical Method of Application For purposes of illustration and disclosure purposes only, the method of application of the present invention will now be described in detail with respect to the closing of an atrial septal defect (ASD) with particular reference to FIGS. lA-C and 9A-K.

In order to gain access to the heart, an incision is made in either the right or left groin under local anesthesia, and the femoral vein isolated. Standard catherization techniques are then utilized to confirm the presence of the ASD such as the one shown in FIG. 1B. Once confirmed, sizing of the ASD is then achieved by means of special but standard balloon catheters, and the appropriate size of umbrella-like closure elements 8, 9 are selected.

The initial closing/catheter assembly (note FIG. i.e., elements I, 2 and 3, the latter having the left umbrella 8 attached to its threaded end 31, is then inserted via the femoral vein into the heart under continuous flouroscopic control into the right atrium. With further advancing of the catheter assembly, it is placed in the left atrium (note FIG. 9A).

By manipulating the obturator wire 3, the distal hub 84 carrying the collapsed left umbrella 8 is advanced beyond the outer, thin wall catheter 1 into the left atrium (FIG. 9B). Once the left umbrella 8 is pushed beyond the tip of the outer, thin wall catheter l, the umbrella 8 is initially unfolded by pushing the inner catheter 2 against the struts 81 and holding fast the obturator wire 3 (FIG. 9C), expanding the umbrella out in excess of the diameter of the outer catheter 1.

Then by pulling gently on the obturator wire 3, the umbrella 8 is pulled against the distal end 11 of the outer catheter 1, opening the umbrella 8 to its full 90 position (FIG. 90). The outer catheter l is then pulled back into the right atria and the umbrella 8 pulled snugly against the left atrial septum, with the distal barbs 83 being anchored against the septum (FIG. 9E).

Once the left umbrella 8 is firmly fixed, the inner catheter 2 is withdrawn and removed and the right umbrella 9 slid into the obturator wire 3 and loaded into the outer catheter l with the retraction ties 7 and retracting ties 7' in place on the struts 91 and sleeve 94, respectively, and the disc 6 (note FIG. 7). The collapsed right umbrella 9 is then pushed through and out the outer catheter l by means of the inner catheter 2 into the right atrium and positioned just superior to the inferior vena cava and right atrial junction (FIG. 9F). At this point the outer catheter 1 is withdrawn to allow the right umbrella 9 to lie freely upon the obturator guide wire 3 within the body of the'right atrium.

As the inner catheter 2 is advanced and traction maintained on the elevating ties 7 and on the retracting sutures or ties 7', the right umbrella 9 is opened (FIG. 90) and pushed snugly against the inter-atrial septum by means of the inner catheter 2. By fluoroscopic monitoring, it can be determined that all six struts 91 are at right angles. The inner catheter 2 is pushed further forward, forcing the sliding sleeve 94 of the right umbrella 9 to slide onto the left umbrella hub 84, locking the two together (FIG. 9H). A clicking sensation is felt through the obturator wire 3, and a click can be heard as the umbrellas 8. 9 are locked in place. Once in place the umbrellas 8. 9 are tugged gently with the obturator guide wire 3 to assure stability.

Once theumbrellas 8, 9 are locked in place, the obturator wire 3 can be unscrewed from the distal hub 84, using the T-piece 5 on the proximal portion of the obturator wire 3, thus leaving in place the distal hub 84 with the right and left umbrellas 8, 9 locked in place (FIG. 91). The obturator guide wires is thus unthreaded with the aid of the T-piece 5 from the left umbrella hub 84 and removed from the heart with the outer and inner catheters 1, 2 (FIG. 9K). Following this, the outer, thin wall catheter l, the inner catheter 2 and the obturator wire 3 are completely withdrawn from the body.

Following installation of the closure structure, a diagnostic venous catheter can be introduced for the appropriate angiograms, dye curves and hydrogen electrode studies to confirm the effectiveness of the closure of the septal defect. The closure structures 8, 9 should be covered by endocardium within 6 to 8 weeks, and be thereby integrated into the heart's structure.

After completion of the operation, the vein and inguinal incision are closed.

Additional Methods of Application For purposes of further illustration and disclosure, the method of application of the present invention will now be described in some detail with respect to the closing of a ventricular septal defect (VSD) with par ticular reference to FIGS. 13 A-C.

In order to gain access to the heart, an incision is made in the right neck over the external or internal jugular vein under local anesthesia. The jugular vein is isolated and venotomy is made for insertion of the outer catheter 1. Standard catherization techniques are then utilized to confirm the presence of the VSD such as the one shown in FIG. 13 B. Once confirmed, sizing of the VSD is then achieved by means of special but standard balloon catheters, and the appropriate size of the left umbrella-like closure element 8' is selected.

The outer catheter is inserted into the vein and subsequently passed into the right heart and manipulated across the ventricular septal defect into the left ventricle. Its position can be documented by obtaining an oxygen sample or passing an NIH catheter through the outer catheter into the left ventrical and doing a hand injection.

The proper size umbrella 8' similar in structure to the left umbrella 8 described above is loaded into the outer catheter and passed into the left ventricle and opened by using the inner catheter in the same manner as is carried out in closing the atrial septal defect as described above. The opened umbrella 8' is pulled snugly against the left side of the interventricular septum adjacent to the ventricular septal defect.

The outer and inner catheters are then removed from the body, leaving the obturator wire 3, and Silastic tubing 3' is passed over the guide wire 3 and subsequently into the heart to entirely cover the exposed guide wire 3.

.By maintaining general pressure on the guide wire 3, the umbrella 8' is held tightly against the left side of the interventricular septum and thus closes the interventricular septal defect. The umbrella 8 is maintained in place by the barbs on the tips of the struts (like those described above) and by the obturator wire 3. Additionally the internal blood pressure system, which is greater in the left ventricle than the right (typically 90 min. Hg vs. 30 min. Hg). serves to help maintain the umbrella 8 over the VSD, closing it off.

The Silastic material 3' and the guide wire 3 are cut off at the appropriate lengths to allow anchoring them in the tissues of the right neck within the jugular vein. The incision is closed, and periodic checks are made of the umbrella 8' over the subsequent minutes by fluoroscopy.

The patient is anticoagulated prior to the installation of the ventricular closing umbrella and is maintained on anticoagulation therapy for several weeks. After about 6 to 8 weeks and the umbrella 8' has been endothelialized. an incision is again made over the proximal end of the Silastic material 3' and guide wire 3 (quite close to the original incision in the neck). The guide wire 3 and Silastic outer covering 3 is isolated, and with the use of the Tpiece 5 on the proximal end of the obturator wire 3, the latter is unscrewed and removed from within the heart and vascular system. The Silastic material 3 is of course removed simultaneously with the guide wire 3, and the incision closed leaving the VSD permanently closed.

Thus. the ventricular septal defect is closed with the use of only a single umbrella 8' with temporary anchoring by the guide wire 3 covered with the Silastic material 3 to prevent clotting and embolization.

To close a patent ductus arteriosus (PDA), for example like that shown in FIG. 148. the same analogous method discussed with respect to the ASD of FIG. 1B and the steps of FIGS. 9 AK can be used. However, because of the longer distance between the left and right outer walls of the PDA, modified aortic and pulmonary umbrella elements 108, 109 are used in place of the left and right umbrella elements 8, 9. The main modification is to extend further out the male member of the aortic umbrella 108 or alternatively the female member 194 (as illustrated in FIG. 14C). Otherwise the structure of the umbrellas I08, 109 can be identical to that disclosed in detail above with respect to the umbrellas 8, 9.

Finally. it is noted that it is advantageous to use the closure structures of the present invention even when open-heart surgery is necessary, as for example in the case of small babies. In such cases, the closure structures of the present invention can be applied through the open heart in a matter ofa few minutes as opposed to the typical 30 to 40 minutes usually taken with standard Suturing of the shunt as practiced in the prior art.

Thus atrial septal defects (FIG. 1) and in similar fashion ventricular septal defects (FIGv 13) and great vessel shunts (FIG. 14) are closed by non-invasive tech niques. The closure catheter system of the present in vention is efficient and with proper caution is safe. The addition of the opening and retracting ties 7, 7 greatly increases the safety of the device. Although it has not yet been found to be necessary to use the retracting eyes or holes 87a and ties for the left struts 81, they may be used if desired.

From past experience with cardiac surgery, stainless steel, particularly of the 300 series, which is the pre ferred material for all structural parts remaining in the heart, and materials such as Dacron, Teflon, nylon. percardium, Silastic and silk can be permanently inserted within the heart and tolerated without adverse effects. It is estimated that the heart will endothelialize the closure elements within 6 to 8 weeks as occurs after standard shunt closures using open-heart surgery.

Because many varying and different embodiments may be made within the scope of the inventive concept herein taught, and because many modifications may be made in the embodiments herein detailed in accordance with the descriptive requirements of the law, it is to be understood that the details herein are to be interpreted as illustrative and not in a limiting sense.

What is claimed as invention is:

1. A shunt defect closure apparatus for closing off a shunt defect in the septum of for example the intravascular system comprising:

mechanical expansion means having an initial size substantially smaller than the diameter of the shunt defect to be closed during its preliminary handling and a final size substantially larger than the diameter of the shunt defect when it is positioned over and across the shunt defect to permanently close it off after being expanded to its larger size, said expansion means comprising a dual set of umbrellalike structures for placement on opposite sides of the shunt defect, the umbrella-like structures having central hub means for connecting said dual set of umbrella-like structures together through the shunt. each said umbrella-like structures including a series of relatively hard, strut-like members emanating out from said central means in at least a generally perpendicular, radial direction when said expansion means is in its final size and in at least a generally parallel. axial direction when said expansion means is in its initial size; and

operative means removably connected with said expansion means for at least temporarily holding the said expansion means on to the shunt defect after at least one of said umbrella-like structures has been expanded out to its final size.

2. The apparatus of claim 1 wherein said umbrellalike structure comprises a series of supporting struts with flexible material suspended between said struts, said struts being moveably attached to a centrally located support element for movement from a closed position to an open position or vice versa.

3. The apparatus of claim 1 wherein said operative means includes an obturator wire having attaching means at it distal end for temporarily attaching said obturator wire to one of said umbrella-like structures 4. The apparatus of claim 3 wherein said operative means further includes an outer catheter serving as a conduit for placing both said umbrella-like structures through the body adjacent to the shunt, said outer catheter having a diameter substantially greater than said obturator wire, said one of said umbrella-like structures being transported through said outer catheter by means of being mounted on the distal portion of said obturator wire and pushing said obturator wire with said one of said umbrella-like structures means thereon through said outer catheter.

5. The apparatus of claim 1 wherein each said urnbrella-like structures includes an expanse of relatively flexible material extending between said strut-like members to thereby at least substantially close off the spaces between said strut-like members.

6. The apparatus of claim 1 wherein said umbrellalike structures have their undersides in opposing relationship to each other and said strut-like members are made of resilient material and resiliently bear inwardly toward the opposing umbrella-like structure. thereby securing the opposing umbrella-like structures to the septum.

7. The apparatus of claim 1 wherein said strut-like members include at their distal tips barb-like means emanating from their underside in a direction at least generally perpendicular thereto for bearing against the septum when each of said umbrella-like structures is moved toward the septum.

8. The apparatus of claim I wherein said operative means includes an obturator wire having attaching means at its distal end for temporary connection to one of said umbrella-like structures and wherein said first one of said umbrella-like structures has a central hub having a connection for temporary connection to said obturator wire; and wherein said second umbrella-like structure has a central sleeve which can slide over said obturator wire, said central hub and said central sleeve having locking means for locking them together in opposing fashion when on opposite sides of the shunt.

9. The apparatus of claim 8 wherein said locking means comprises a male-female connection between said central hub and said central sleeve, the exterior of said connection means of said central hub forming the male member and the interior of said sleeve forming at least in part the female orifice.

10. The apparatus of claim 9 wherein said male member includes a projection on its mating surface and said female orifice includes an indentation for further mating with said projection and locking the hub and sleeve together.

11. A shunt defect closure apparatus for closing off a shunt defect in the septum of for example the intravascular system comprising:

mechanical expansion means having an initial size substantially smaller than the diameter of the shunt defect to be closed during its preliminary handling and a final size substantially larger than the diameter of the shunt defect when it is positioned over and across the shunt defect to permanently close it off after being expanded to its larger size, said expansion means comprising at least one umbrellalike structure for placement on; one side of the shunt, said umbrella-like structure having central hub means of at least a generally c'ylindrical shape for having pressure applied to it along its longitudinal axis for forcing the distal, end portions of the underside of said umbrella-like structure against the septum to at least partially close the shunt, said umbrella-like structure being of a material that will be endothelialized into the septum; the main surface of the umbrella-like structure in its expanded size being at least substantially perpendicular and radial to said central hub means and hence to the central axis of the shunt; and operative means associated'with said expansion means for at least temporarily holding said expansion means on to the shunt defect.

12. The apparatus of claim 1] wherein the underside of said urn brella-like structure has on its distal portions bearing means for hearing against the septum, the bearing direction being generally perpendicular to the main surface of said umbrella-like structure and hence parallel to the central axis of the shunt.

13. The apparatus of claim 11 wherein said umbrellalike structure in its final size includes a series of relatively hard strut-like members radially emanating out from said extended central means in a direction at least generally perpendicular thereto, the distal tips of said strut-like members including barb-like structures emanating in a direction at least generally perpendicular thereto, said barbs serving as said bearing means.

14. The apparatus of claim 11 wherein said umbrellalike structure includes an expanse of relatively flexible material extending between said strut-like members to thereby at least substantially close off the spaces between said strut-like members.

15. The apparatus of claim ll wherein said strut-like members are made of resilient material and resiliently bear inwardly toward the septum when the umbrellalike structure is-in its final size, thereby securing the umbrella-like structure to the septum.

16. A shunt defect closure apparatus for closing off a shunt defect in the septum of for example the intravascular system comprising.

mechanical expansion means having an initial size substantially smaller than the diameter of the shunt defect to be closed during its preliminary handling and a final substantially larger than the diameter of the shunt defect when it is positioned over and across the shunt defect to permanently close it off after being expanded to its larger size, said expansion means comprising at least one expansion structure being of a material that will be endothelialized into the septum and having an extended, main body with a facing side for contacting the septum surface around the shunt and being extended at least in part in a direction at least generally parallel to the septum surface, and extended central hub means centrally located within said main body and being extended in a direction at least generally perpendicular to the septum surface for having pressure applied to it along its extended direction for forcing the distal, end portions of the facing side of said expansion structure against the septum to at least partially close the shunt, the facing side of said expansion structure having on its distal portions anchoring means for anchoring said expansion structure to the septum. when said expansion structure is forced against the septum, said anchoring means comprising projections extending at least partially in a direction parallel to said extended central means and hence parallel to the central axis of the shunt and perpendicular to the septum surface.

17. The apparatus of claim 16 wherein said expansion structure is an umbrella-like structure having a series of relatively hard strut-like members radially emanating from said extended central means, and having projections at their distal ends, said projections being barb-like structures emanating in a direction at least generally perpendicular to the emanating direction of said strut-like members.

18. The apparatus of claim 17 wherein said umbrellalike structure includes an expanse of relatively flexible material extending between said strut-like members to thereby at least substantially close off the spaces between said strut-like members.

19. The apparatus of claim 17 wherein said strut-like members are made of resilient material and resiliently bear inwardly toward the septum when the umbrellalike structure is in its final size, thereby securing the umbrella-like structure to the septum.

20. The method of closing off a ventricular septal defeet in the intravascular system comprising the following sequential steps:

a. providing a ventricular septal defect closure structure for closing off the ventricular septal defect comprising mechanical expansion means having an initial size substantially smaller than the diameter of the intravascular shunt defect to be closed and a final size substantially larger than the diameter of the septal defect for positioning over and across the septal defect to permanently close it off after being expanded to its larger size, said expansion means being made of a tissue compatible material which can be endothelialized into the septum; and operative means associated with said expansion means for at least temporarily holding the said expansion means on to the defect, said operative means incuding an obturator wire having attaching means at its distal end for temporarily attaching said obturator wire to said expansion means;

b. making a relatively small, minor incision or opening in the body and into a vein having access to the ventricle with the defect;

c. introducing the obturator wire with said closure structure attached to its distal end while in its smaller size into said opening and through the septal defect;

d. expanding said expansion means of said closure structure to its larger size;

e. using said obturator wire to position and attach said expansion means of said closure structure while in its larger size over and across the far side of the septal defect, closing the septal defect;

closing off said opening in the body with said obturator wire still attached to said expansion means; g. allowing said expansion means of said closure structure to become endothelialized over a substantial period of time, further closing off the septal defect;

h. reopening the opening in said body and removing said obturator wire; and

i. permanently closing off said opening; whereby the shunt is permanently closed by substantially noninvasive or at least limitedly evasive techniques and without the substantial suturing of the shunt as practiced in the prior art.

21. The method of claim wherein in step (b) the vein used for the opening is the external or internal jugular vein and the incision is made in the neck.

22. The method of closing off a shunt defect in the septum of for example the intravascular system comprising the following steps:

a. providing a shunt defect closure-structure for closing off the shunt defect comprising mechanical expansion means having an initial size substantially smaller than the diameter of the intravascular shunt defect to be closed and a final size substantially larger than the diameter of the shunt defect for positioning over and across the shunt defect to permanently close it off after being expanded to its larger size, said expansion means comprising at least one umbrella-like structure for placement on the side of the shunt, said umbrella-like structure including a central hub having a series of relatively hard, strut-like members emanating out from said central hub in at least a generally parallel, axial direction when said expansion means is in its initial size and a generally perpendicular, radial direction when said expansion means is in its final size, said umbrella-like structure being made of a tissue compatible material which can be endothelialized into the septum; and operative means associated with said expansion means for at least temporarily holding the said expansion means on to the shunt defeet;

b. making an opening in the body;

c. introducing said closure structure while in its smaller size in proximity to the shunt to be closed by means of said opening;

d. expanding said umbrella-like structure of said closure structure to its larger size by expanding out said strut-like members;

e. permanently positioning and attaching said umbrella-like structure of said closure structure while in its larger size over and across the shunt, closing the shunt;

f. allowing said umbella-like structure of said closure structure to become endothelialized, further closing off the shunt; and

g. ultimately closing off said opening; whereby the shunt is permanently closed by substantially noninvasive or at least limitedly evasive techniques and without the substantial suturing of the shunt as practiced in the prior art.

23. The method of claim 22 wherein in step (b) the opening in the body is made by making a relatively small, minor incision to gain access to a vein or artery of the blood circulatory system; and wherein in step (c) the introduction is made through said vein or artery.

24. The method of claim 22 wherein in step (a) in providing said expansion means there is further included the providing of a second umbrella-like structure having the same claimed features as the first umbrella-like structure for placement on the opposite side of the shunt from said first umbrella-like structure and steps (c) through (d) inclusive are each repeated for said second umbrella-like structure.

25. The method of claim 24 wherein in step (a) said operative means are provided by providing an outer catheter having a cross-sectional area smaller than the shunt and an obturator wire having a diameter substantially smaller than said outer cathether; and wherein in step (b) the opening in the body is made by making a relatively small minor incision to gain access to a vein or artery; and wherein in step (c) the introduction is made through said vein or artery and includes the following steps:

i. inserting said outer catheter through the incision into and through the vein/artery until its distal end is in juxtaposition to the shunt and, for said first umbrella-like structure, is passed through the shunt but, for the second umbrella-like structure, is located on the proximal side of the shunt; and

ii. moving said umbrella-like structures out of the distal end of said outer catheter.

26. The method of claim 25 wherein in step (c) there is further included in sub-step (ii) the steps of:

attaching said first umbrella-like structure to the distal end of said obturator wire and inserting the obturator wire with said first umbrella-like structure attached thereto in its initial size into and through the outer catheter until said first umbrella-like structure has emerged out of the distal end of said outer catheter;

17 and wherein the step (e) the underside of said first umbrella-like structure is pulled against the distal side of the septum. 27. The method of claim 25 wherein in step (a) in providing said second umbrella-like structure there is further included the providing of a central sleeve with a central orifice having a diameter greater than said ohturator wire but less than said outer catheter; and wherein in step (c) there is further included in sub-step (ii) the steps of:

28. The method ofclaim 27 wherein in step (a) additional operative means are provided by providing a second, inner catheter having a diameter smaller than said outer catheter and having a central longitudinal opening along its length ofa diameter larger than the diameter of said obturator wire and being slidable thereon and having a tip at its distal end; and wherein, in the step (e) for said second umbrella-like structure, the underside of said second umbrella-like structure is pushed against the proximal side of the septum by pushing the tip of said inner catheter against the central sleeve of said second umbrella-like structure.

29. The method of claim 28 wherein in step (a) the central hub of said first umbrella-like structure is provided with a centrally located, locking male member, the center of which serves as the connecting means for attaching the central hub to the distal end of the obturator wire; and wherein, the step (e) for said second umbrella-like structure, said inner catheter is used to push the central sleeve of said second umbrella-like structure so that its orifice, which then serves also as a female member, is pushed into the locking male member of said first umbrella-like structure, locking the two umbrella-like structures together.

30. The method of claim 28 wherein in step (a) the strut-like members of said second umbrella-like structure are provided with a set of elevating struts hingedly connected at one end to the strut-like members at a point removed from said central sleeve and at the other end to a centrally located, leading and elevating member; and wherein, in the step (d) for said second umbrella-like member, said second umbrella-like structure is expanded by pushing said central sleeve toward said elevating member by means of said inner catheter, causing said elevating struts to push said strut-like members out away from said central sleeve.

Claims (30)

1. A shunt defect closure apparatus for closing off a shunt defect in the septum of for example the intravascular system comprising: mechanical expansion means having an initial size substantially smaller than the diameter of the shunt defect to be closed during its preliminary handling and a final size substantially larger than the diameter of the shunt defect when it is positioned over and across the shunt defect to permanently close it off after being expanded to its larger size, said expansion means comprising a dual set of umbrella-like structures for placement on opposite sides of the shunt defect, the umbrella-like structures having central hub means for connecting said dual set of umbrella-like structures together through the shunt, each said umbrella-like structures including a series of relatively hard, strut-like members emanating out from said central means in at least a generally perpendicular, radial direction when said expansion means is in its final size and in at least a generally parallel, axial direction when said expansion means is in its initial size; and operative means removably connected with said expansion means for at least temporarily holding the said expansion means on to the shunt defect after at least one of said umbrella-like structures has been expanded out to its final size.
2. The apparatus of claim 1 wherein said umbrella-like structure comprises a series of supporting struts with flexible material suspended between said struts, said struts being moveably attached to a centrally located support element for movement from a closed position to an open position or vice versa.
3. The apparatus of claim 1 wherein said operative means includes an obturator wire having attaching means at it distal end for temporarily attaching said obturator wire to one of said umbrella-like structures
4. The apparatus of claim 3 wherein said operative means further includes an outer catheter serving as a conduit for placing both said umbrella-like structures through the body adjacent to the shunt, said outer catheter having a diameter substantially greater than said obturator wire, said one of said umbrella-like structures being transported through said outer catheter by means of being mounted on the distal portion of said obturator wire and pushing said obturator wire with said one of said umbrella-like structures means thereon through said outer catheter.
5. The apparatus of claim 1 wherein each said umbrella-like structures includes an expanse of relatively flexible material extending between said strut-like members to thereby at least substantially close off the spaces between said strut-like members.
6. The apparatus of claim 1 wherein said umbrella-like structures have their undersides in opposing relationship to each other and said strut-like members are made of resilient material and resiliently bear inwardly toward the opposing umbrella-like structure, thereby securing the opposing umbrella-like structures to the septum.
7. The apparatus of claim 1 wherein said strut-like members include at their distal tips barb-like means emanating from their underside in a direction at least generally perpendicular thereto for bearing against the septum when each of said umbrella-like structures is moved toward the septum.
8. The apparatus of claim 1 wherein said operative means includes an obturator wire having attaching means at its distal end for temporary connection to one of said umbrella-like structures and wherein said first one of said umbrella-like structures has a central hub having a connection for temporary connection to said obturator wire; and wherein said second umbrella-like structure has a central sleeve which can slide over said obturator wire, said central hub and said central sleeve having locking means for locking them together in opposing fashion when on opposite sides of the shunt.
9. The apparatus of claim 8 wherein said locking means comprises a male-female connection between said central hub and said central sleeve, the exterior of said connection means of said central hub forming the male member and the interior of said sleeve forming at least in part the female orifice.
10. The apparatus of claim 9 wherein said male member includes a projection on its mating surface and said female orifice includes an indentation for further mating with said projection and locking the hub and sleeve together.
11. A shunt defect closure apparatus for closing off a shunt defect in the septum of for example the intravascular system comprising: mechanical expansion means having an initial size substantially smaller than the diameter of the shunt defect to be closed during its preliminary handling and a final size substantially larger than the diameter of the shunt defect when it is positioned over and across the shunt defect to permanently close it off after being expanded to its larger size, said expansion means comprising at least one umbrella-like structure for placement on one side of the shunt, said umbrella-like structure having central hub means of at least a generally cylindrical shape for having pressure applied to it along its longitudinal axis for forcing the distal, end portions of the underside of said umbrella-like structure against the septum to at least partially close the shunt, said umbrella-like structure being of a material that will be endothelialized into the septum; the main surface of the umbrella-like structure in its expanded size being at least substantially perpendicular and radial to said central hub means and hence to the central axis of the shunt; and operative means associated with said expansion means for at least temporarily holding said expansion means on to the shunt defect.
12. The apparatus of claim 11 wherein the underside of said umbrella-like structure has on its distal portions bearing means for bearing against the septum, the bearing direction being generally perpendicular to the main surface of said umbrella-like structure and hence parallel to the central axis of the shunt.
13. The apparatus of claim 11 wherein said umbrella-like structure in its final size includes a series of relatively hard strut-like members radially emanating out from said extended central means in a direction at least generally perpendicular thereto, the distal tips of said strut-like members including barb-like structures emanating in a direction at least generally perpendicular thereto, said barbs serving as said bearing means.
14. The apparatus of claim 11 wherein said umbrella-like structure includes an expanse of relatively flexible material extending between said strut-like members to thereby at least substantially close off the spaces between said strut-like members.
15. The apparatus of claim 11 wherein said strut-like members are made of resilient material and resiliently bear inwardly toward the septum when the umbrella-like structure is in its final size, thereby securing the umbrella-like structure to the septum.
16. A shunt defect closure apparatus for closing off a shunt defect in the septum of for exammvTHE INTRAVASCULAR system comprising: mechanical expansion means having an initial size substantially smaller than the diameter of the shunt defect to be closed during its preliminary handling and a final substantially larger than the diameter of the shunt defect when it is positioned over and across the shunt defect to permanently close it off after being expanded to its larger size, said expansion means comprising at least one expansion structure being of a material that will be endothelialized into the septum and having an extended, main body with a facing side for contacting the septum surface around the shunt and being extended at least in part in a direction at least generally parallel to the septum surface, and extended central hub means centrally located within said main body and being exteNded in a direction at least generally perpendicular to the septum surface for having pressure applied to it along its extended direction for forcing the distal, end portions of the facing side of said expansion structure against the septum to at least partially close the shunt, the facing side of said expansion structure having on its distal portions anchoring means for anchoring said expansion structure to the septum, when said expansion structure is forced against the septum, said anchoring means comprising projections extending at least partially in a direction parallel to said extended central means and hence parallel to the central axis of the shunt and perpendicular to the septum surface.
17. The apparatus of claim 16 wherein said expansion structure is an umbrella-like structure having a series of relatively hard strut-like members radially emanating from said extended central means, and having projections at their distal ends, said projections being barb-like structures emanating in a direction at least generally perpendicular to the emanating direction of said strut-like members.
18. The apparatus of claim 17 wherein said umbrella-like structure includes an expanse of relatively flexible material extending between said strut-like members to thereby at least substantially close off the spaces between said strut-like members.
19. The apparatus of claim 17 wherein said strut-like members are made of resilient material and resiliently bear inwardly toward the septum when the umbrella-like structure is in its final size, thereby securing the umbrella-like structure to the septum.
20. The method of closing off a ventricular septal defect in the intravascular system comprising the following sequential steps: a. providing a ventricular septal defect closure structure for closing off the ventricular septal defect comprising mechanical expansion means having an initial size substantially smaller than the diameter of the intravascular shunt defect to be closed and a final size substantially larger than the diameter of the septal defect for positioning over and across the septal defect to permanently close it off after being expanded to its larger size, said expansion means being made of a tissue compatible material which can be endothelialized into the septum; and operative means associated with said expansion means for at least temporarily holding the said expansion means on to the defect, said operative means incuding an obturator wire having attaching means at its distal end for temporarily attaching said obturator wire to said expansion means; b. making a relatively small, minor incision or opening in the body and into a vein having access to the ventricle with the defect; c. introducing the obturator wire with said closure structure attached to its distal end while in its smaller size into said opening and through the septal defect; d. expanding said expansion means of said closure structure to its larger size; e. using said obturator wire to position and attach said expansion means of said closure structure while in its larger size over and across the far side of the septal defect, closing the septal defect; f. closing off said opening in the body with said obturator wire still attached to said expansion means; g. allowing said expansion means of said closure structure to become endothelialized over a substantial period of time, further closing off the septal defect; h. reopening the opening in said body and removing said obturator wire; and i. permanently closing off said opening; whereby the shunt is permanently closed by substantially non-invasive or at least limitedly evasive techniques and without the substantial suturing of the shunt as practiced in the prior art.
21. The method of claim 20 wherein in step (b) the vein used for the opening is the external or internal jugular vein and the incision is made in the neck.
22. The method of closing off a shunt defect in the septum of for example the iNtravascular system comprising the following steps: a. providing a shunt defect closure-structure for closing off the shunt defect comprising mechanical expansion means having an initial size substantially smaller than the diameter of the intravascular shunt defect to be closed and a final size substantially larger than the diameter of the shunt defect for positioning over and across the shunt defect to permanently close it off after being expanded to its larger size, said expansion means comprising at least one umbrella-like structure for placement on the side of the shunt, said umbrella-like structure including a central hub having a series of relatively hard, strut-like members emanating out from said central hub in at least a generally parallel, axial direction when said expansion means is in its initial size and a generally perpendicular, radial direction when said expansion means is in its final size, said umbrella-like structure being made of a tissue compatible material which can be endothelialized into the septum; and operative means associated with said expansion means for at least temporarily holding the said expansion means on to the shunt defect; b. making an opening in the body; c. introducing said closure structure while in its smaller size in proximity to the shunt to be closed by means of said opening; d. expanding said umbrella-like structure of said closure structure to its larger size by expanding out said strut-like members; e. permanently positioning and attaching said umbrella-like structure of said closure structure while in its larger size over and across the shunt, closing the shunt; f. allowing said umbella-like structure of said closure structure to become endothelialized, further closing off the shunt; and g. ultimately closing off said opening; whereby the shunt is permanently closed by substantially non-invasive or at least limitedly evasive techniques and without the substantial suturing of the shunt as practiced in the prior art.
23. The method of claim 22 wherein in step (b) the opening in the body is made by making a relatively small, minor incision to gain access to a vein or artery of the blood circulatory system; and wherein in step (c) the introduction is made through said vein or artery.
24. The method of claim 22 wherein in step (a) in providing said expansion means there is further included the providing of a second umbrella-like structure having the same claimed features as the first umbrella-like structure for placement on the opposite side of the shunt from said first umbrella-like structure and steps (c) through (d) inclusive are each repeated for said second umbrella-like structure.
25. The method of claim 24 wherein in step (a) said operative means are provided by providing an outer catheter having a cross-sectional area smaller than the shunt and an obturator wire having a diameter substantially smaller than said outer cathether; and wherein in step (b) the opening in the body is made by making a relatively small minor incision to gain access to a vein or artery; and wherein in step (c) the introduction is made through said vein or artery and includes the following steps: i. inserting said outer catheter through the incision into and through the vein/artery until its distal end is in juxtaposition to the shunt and, for said first umbrella-like structure, is passed through the shunt but, for the second umbrella-like structure, is located on the proximal side of the shunt; and ii. moving said umbrella-like structures out of the distal end of said outer catheter.
26. The method of claim 25 wherein in step (c) there is further included in sub-step (ii) the steps of: attaching said first umbrella-like structure to the distal end of said obturator wire and inserting the obturator wire with said first umbrella-like structure attached thereto in its initial size into and through the outer catheter until said first umbrella-like structure has emerged out of the distal end of said oUter catheter; and wherein the step (e) the underside of said first umbrella-like structure is pulled against the distal side of the septum.
27. The method of claim 25 wherein in step (a) in providing said second umbrella-like structure there is further included the providing of a central sleeve with a central orifice having a diameter greater than said obturator wire but less than said outer catheter; and wherein in step (c) there is further included in sub-step (ii) the steps of: sliding said central sleeve of said second umbrella-like structure over said obturator wire and passing said second umbrella-like structure through said outer catheter while in its initial size until said second umbrella-like structure has emerged out of the distal end of said outer catheter; and wherein in step (e) the underside of said second umbrella-like structure is pushed against the proximal side of the septum.
28. The method of claim 27 wherein in step (a) additional operative means are provided by providing a second, inner catheter having a diameter smaller than said outer catheter and having a central longitudinal opening along its length of a diameter larger than the diameter of said obturator wire and being slidable thereon and having a tip at its distal end; and wherein, in the step (e) for said second umbrella-like structure, the underside of said second umbrella-like structure is pushed against the proximal side of the septum by pushing the tip of said inner catheter against the central sleeve of said second umbrella-like structure.
29. The method of claim 28 wherein in step (a) the central hub of said first umbrella-like structure is provided with a centrally located, locking male member, the center of which serves as the connecting means for attaching the central hub to the distal end of the obturator wire; and wherein, the step (e) for said second umbrella-like structure, said inner catheter is used to push the central sleeve of said second umbrella-like structure so that its orifice, which then serves also as a female member, is pushed into the locking male member of said first umbrella-like structure, locking the two umbrella-like structures together.
30. The method of claim 28 wherein in step (a) the strut-like members of said second umbrella-like structure are provided with a set of elevating struts hingedly connected at one end to the strut-like members at a point removed from said central sleeve and at the other end to a centrally located, leading and elevating member; and wherein, in the step (d) for said second umbrella-like member, said second umbrella-like structure is expanded by pushing said central sleeve toward said elevating member by means of said inner catheter, causing said elevating struts to push said strut-like members out away from said central sleeve.
US3874388A 1973-02-12 1973-02-12 Shunt defect closure system Expired - Lifetime US3874388A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US3874388A US3874388A (en) 1973-02-12 1973-02-12 Shunt defect closure system
GB1247575A GB1509023A (en) 1973-02-12 1975-03-25 Septal defect closure apparatus
AU7953175A AU7953175A (en) 1973-02-12 1975-03-26 Shunt defect closure system
FR7509736A FR2305165B1 (en) 1973-02-12 1975-03-27
DE19752514142 DE2514142A1 (en) 1973-02-12 1975-03-29 Device for closing septal defects or nebenschluessen

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3874388A US3874388A (en) 1973-02-12 1973-02-12 Shunt defect closure system
GB1247575A GB1509023A (en) 1973-02-12 1975-03-25 Septal defect closure apparatus
AU7953175A AU7953175A (en) 1973-02-12 1975-03-26 Shunt defect closure system
FR7509736A FR2305165B1 (en) 1973-02-12 1975-03-27
DE19752514142 DE2514142A1 (en) 1973-02-12 1975-03-29 Device for closing septal defects or nebenschluessen

Publications (1)

Publication Number Publication Date
US3874388A true US3874388A (en) 1975-04-01

Family

ID=27507254

Family Applications (1)

Application Number Title Priority Date Filing Date
US3874388A Expired - Lifetime US3874388A (en) 1973-02-12 1973-02-12 Shunt defect closure system

Country Status (4)

Country Link
US (1) US3874388A (en)
DE (1) DE2514142A1 (en)
FR (1) FR2305165B1 (en)
GB (1) GB1509023A (en)

Cited By (888)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4031569A (en) * 1976-03-15 1977-06-28 Jacob H John Nasal septum plug
US4056854A (en) * 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4092742A (en) * 1976-10-18 1978-06-06 Sinai Hospital Of Detroit Dynamic prosthetic myocardium
US4562596A (en) * 1984-04-25 1986-01-07 Elliot Kornberg Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair
FR2573647A1 (en) * 1984-11-28 1986-05-30 Catier Philippe Device for repairing a meniscus by endoscopy alone
US4617932A (en) * 1984-04-25 1986-10-21 Elliot Kornberg Device and method for performing an intraluminal abdominal aortic aneurysm repair
US4710192A (en) * 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4744364A (en) * 1987-02-17 1988-05-17 Intravascular Surgical Instruments, Inc. Device for sealing percutaneous puncture in a vessel
US4773420A (en) * 1987-06-22 1988-09-27 U.S. Surgical Corporation Purse string applicator
US4779616A (en) * 1986-02-04 1988-10-25 Johnson Lanny L Surgical suture-snagging method
US4787899A (en) * 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US4793348A (en) * 1986-11-15 1988-12-27 Palmaz Julio C Balloon expandable vena cava filter to prevent migration of lower extremity venous clots into the pulmonary circulation
US4836204A (en) * 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
US4852568A (en) * 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
WO1989011301A1 (en) * 1988-05-16 1989-11-30 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
EP0362113A1 (en) * 1988-08-29 1990-04-04 Eleftherios B. Sideris Buttoned device for the transvenous occlusion of intracardiac defects
US5021059A (en) * 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
US5053046A (en) * 1988-08-22 1991-10-01 Woodrow W. Janese Dural sealing needle and method of use
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5116357A (en) * 1990-10-11 1992-05-26 Eberbach Mark A Hernia plug and introducer apparatus
US5122155A (en) * 1990-10-11 1992-06-16 Eberbach Mark A Hernia repair apparatus and method of use
US5141515A (en) * 1990-10-11 1992-08-25 Eberbach Mark A Apparatus and methods for repairing hernias
WO1992019162A2 (en) * 1991-04-24 1992-11-12 Seid Arnold S Surgical implantation device and related method of use
US5171259A (en) * 1990-04-02 1992-12-15 Kanji Inoue Device for nonoperatively occluding a defect
US5192302A (en) * 1989-12-04 1993-03-09 Kensey Nash Corporation Plug devices for sealing punctures and methods of use
US5192300A (en) * 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
EP0534696A1 (en) * 1991-09-23 1993-03-31 Jay Erlebacher A sealing device and an insertion tool therefor
EP0544485A1 (en) * 1991-11-25 1993-06-02 Cook Incorporated Tissue aperture repair device
WO1993010714A1 (en) * 1991-11-29 1993-06-10 William Cook Europe A/S Closure prosthesis for transcatheter placement
US5222974A (en) * 1991-11-08 1993-06-29 Kensey Nash Corporation Hemostatic puncture closure system and method of use
WO1993013712A1 (en) * 1992-01-21 1993-07-22 Regents Of The University Of Minnesota Septal defect closure device
EP0556564A2 (en) * 1992-01-22 1993-08-25 C.R. Bard, Inc. System and method for the percutaneous transluminal delivery and retrieval of a prosthetic occluder
US5258000A (en) * 1991-11-25 1993-11-02 Cook Incorporated Tissue aperture repair device
US5275622A (en) * 1983-12-09 1994-01-04 Harrison Medical Technologies, Inc. Endovascular grafting apparatus, system and method and devices for use therewith
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
WO1994008513A1 (en) * 1992-10-13 1994-04-28 Taymor Luria Howard Percutaneous vascular sealing apparatus and method
WO1994017738A2 (en) * 1993-02-03 1994-08-18 Kensey Nash Corporation Hemostatic vessel puncture closure system and method of use
US5342393A (en) * 1992-08-27 1994-08-30 Duke University Method and device for vascular repair
US5383477A (en) * 1991-08-02 1995-01-24 Dematteis; Ralph A. Method and apparatus for laparoscopic repair of hernias
US5383897A (en) * 1992-10-19 1995-01-24 Shadyside Hospital Method and apparatus for closing blood vessel punctures
WO1995002371A2 (en) * 1993-07-15 1995-01-26 Aws Shakir Mustafa Salim Rectal and rectosigmoid cancer tunnelling umbrella
USRE34866E (en) * 1987-02-17 1995-02-21 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
US5397345A (en) * 1983-12-09 1995-03-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US5405360A (en) * 1992-02-24 1995-04-11 United States Surgical Corporation Resilient arm mesh deployer
US5413571A (en) * 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
US5425744A (en) * 1991-11-05 1995-06-20 C. R. Bard, Inc. Occluder for repair of cardiac and vascular defects
FR2714284A1 (en) * 1993-12-23 1995-06-30 Petitier Hubert Prosthesis for repairing heart wall defects
US5431639A (en) * 1993-08-12 1995-07-11 Boston Scientific Corporation Treating wounds caused by medical procedures
US5433727A (en) * 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
US5451235A (en) * 1991-11-05 1995-09-19 C.R. Bard, Inc. Occluder and method for repair of cardiac and vascular defects
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
EP0698373A2 (en) * 1994-08-24 1996-02-28 Bernhard Schneidt Occlusion device for closing an opening in a vessel
US5507744A (en) * 1992-04-23 1996-04-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US5507811A (en) * 1993-11-26 1996-04-16 Nissho Corporation Prosthetic device for atrial septal defect repair
EP0706778A1 (en) * 1994-10-13 1996-04-17 Ethicon, Inc. Applicator for introducing flexible areal implants through an operative channel
WO1996032882A1 (en) 1995-04-20 1996-10-24 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US5593422A (en) * 1989-05-29 1997-01-14 Muijs Van De Moer; Wouter M. Occlusion assembly for sealing openings in blood vessels and a method for sealing openings in blood vessels
US5620461A (en) * 1989-05-29 1997-04-15 Muijs Van De Moer; Wouter M. Sealing device
US5634936A (en) * 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
US5643317A (en) * 1992-11-25 1997-07-01 William Cook Europe S.A. Closure prosthesis for transcatheter placement
US5649959A (en) * 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
US5676689A (en) * 1991-11-08 1997-10-14 Kensey Nash Corporation Hemostatic puncture closure system including vessel location device and method of use
US5683411A (en) * 1994-04-06 1997-11-04 William Cook Europe A/S Medical article for implantation into the vascular system of a patient
WO1997042878A1 (en) 1996-05-14 1997-11-20 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US5713907A (en) * 1995-07-20 1998-02-03 Endotex Interventional Systems, Inc. Apparatus and method for dilating a lumen and for inserting an intraluminal graft
US5741297A (en) * 1996-08-28 1998-04-21 Simon; Morris Daisy occluder and method for septal defect repair
US5749918A (en) * 1995-07-20 1998-05-12 Endotex Interventional Systems, Inc. Intraluminal graft and method for inserting the same
EP0856285A1 (en) * 1997-01-30 1998-08-05 Nissho Corporation Device for intracardiac suture
US5810810A (en) * 1992-04-23 1998-09-22 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US5846261A (en) * 1994-07-08 1998-12-08 Aga Medical Corp. Percutaneous catheter directed occlusion devices
US5853422A (en) * 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
WO1999007289A1 (en) 1997-08-08 1999-02-18 Cardia, Inc. Occlusion device for the closure of a physical anomaly
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5895404A (en) * 1997-09-29 1999-04-20 Ruiz; Carlos E. Apparatus and methods for percutaneously forming a passageway between adjacent vessels or portions of a vessel
JPH11146888A (en) * 1997-08-27 1999-06-02 Ethicon Inc Prosthesis for hernia treatment
EP0920842A1 (en) * 1996-07-09 1999-06-09 Vladimir Leonidovich Karpenko Micro-surgery fixation device, variants and manipulation push-bar for mounting the same
WO1999039646A1 (en) 1998-02-06 1999-08-12 Aga Medical Corp. Percutaneous catheter directed constricting occlusion device
WO1999040849A1 (en) 1998-02-10 1999-08-19 Jeffrey Jump Surgical device for occlusion of defects
US5976174A (en) * 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US6007563A (en) * 1991-11-08 1999-12-28 Kensey Nash Corporation Method of deploying percutaneous puncture closure
US6015427A (en) * 1997-07-07 2000-01-18 Eclipse Surgical Technologies, Inc. Heart stabilizer with controllable stay suture and cutting element
US6024096A (en) * 1998-05-01 2000-02-15 Correstore Inc Anterior segment ventricular restoration apparatus and method
US6029671A (en) * 1991-07-16 2000-02-29 Heartport, Inc. System and methods for performing endovascular procedures
US6063085A (en) * 1992-04-23 2000-05-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US6113641A (en) * 1997-08-27 2000-09-05 Ethicon, Inc. Prosthesis for the obturation of a hernial canal
US6152144A (en) * 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6168615B1 (en) 1998-05-04 2001-01-02 Micrus Corporation Method and apparatus for occlusion and reinforcement of aneurysms
US6171329B1 (en) 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US6180848B1 (en) 1997-08-27 2001-01-30 Ethicon, Inc. Prosthesis obturating device for the obturation of a hernial canal
EP1079741A1 (en) * 1998-05-26 2001-03-07 Boston Scientific Limited Implantable tissue fastener and system for treating gastroesophageal reflux disease
WO2001021247A1 (en) 1999-09-20 2001-03-29 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6214029B1 (en) * 2000-04-26 2001-04-10 Microvena Corporation Septal defect occluder
US6221104B1 (en) 1998-05-01 2001-04-24 Cor Restore, Inc. Anterior and interior segment cardiac restoration apparatus and method
US6290674B1 (en) 1999-09-20 2001-09-18 Appriva Medical, Inc. Method and apparatus for closing intracardiac septal defects
US6293951B1 (en) * 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US6309350B1 (en) 1999-05-03 2001-10-30 Tricardia, L.L.C. Pressure/temperature/monitor device for heart implantation
US6328757B1 (en) 1999-04-23 2001-12-11 Robert G. Matheny Device and method for performing surgery without impeding organ function
US6344053B1 (en) 1993-12-22 2002-02-05 Medtronic Ave, Inc. Endovascular support device and method
US6346074B1 (en) 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US20020022860A1 (en) * 2000-08-18 2002-02-21 Borillo Thomas E. Expandable implant devices for filtering blood flow from atrial appendages
US6368339B1 (en) 1994-07-08 2002-04-09 Aga Medical Corporation Method of forming medical devices: intra-vascular occlusion devices
US6379368B1 (en) * 1999-05-13 2002-04-30 Cardia, Inc. Occlusion device with non-thrombogenic properties
US6387104B1 (en) 1999-11-12 2002-05-14 Scimed Life Systems, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US6398782B1 (en) 1992-10-13 2002-06-04 Edwards Lifesciences Corporation Bipolar vascular sealing apparatus and methods
US20020077661A1 (en) * 2000-12-20 2002-06-20 Vahid Saadat Multi-barbed device for retaining tissue in apposition and methods of use
US20020095209A1 (en) * 1997-09-16 2002-07-18 Gholam-Reza Zadno-Azizi Body fluid flow control device
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
US6440152B1 (en) 2000-07-28 2002-08-27 Microvena Corporation Defect occluder release assembly and method
US6440120B1 (en) * 1998-09-02 2002-08-27 Embol-X, Inc. Bendable shape-retaining cannula
US20020133227A1 (en) * 2001-02-28 2002-09-19 Gregory Murphy Ventricular restoration patch apparatus and method of use
US20020133054A1 (en) * 2001-02-28 2002-09-19 Gregory Murphy Sizing apparatus and method for use during ventricular restoration
US20020143292A1 (en) * 2001-04-02 2002-10-03 Flinchbaugh David E. Conformable balloonless catheter
WO2002038051A3 (en) * 2000-11-07 2002-10-31 Carag Ag A device for plugging an opening such as in a wall of a hollow or tubular organ
US20020165561A1 (en) * 2001-05-01 2002-11-07 Stephen Ainsworth Self-closing surgical clip for tissue
US20020173742A1 (en) * 2001-04-20 2002-11-21 Gad Keren Methods and apparatus for reducing localized circulatory system pressure
US20020183787A1 (en) * 2001-06-01 2002-12-05 Velocimed, L.L.C. Closure devices, related delivery methods and tools, and related methods of use
US20020183823A1 (en) * 2001-06-04 2002-12-05 Ramesh Pappu Cardiac stimulating apparatus having a blood clot filter and atrial pacer
US20030004302A1 (en) * 2001-05-15 2003-01-02 Satoshi Okamoto Process for producing purified polyether sulfones
US6508828B1 (en) 2000-11-03 2003-01-21 Radi Medical Systems Ab Sealing device and wound closure device
WO2003006096A1 (en) * 2001-07-09 2003-01-23 Argmed Kommanditbolag Flow path control catheter with funnel-shaped expandable structure at proximal part and tubular-shaped structure at distal part and perfusion system with such a catheter
US20030023262A1 (en) * 2001-07-18 2003-01-30 Jeffrey Welch Cardiac implant device tether system and method
US20030023300A1 (en) * 1999-12-31 2003-01-30 Bailey Steven R. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20030028213A1 (en) * 2001-08-01 2003-02-06 Microvena Corporation Tissue opening occluder
US20030045901A1 (en) * 2001-09-06 2003-03-06 Nmt Medical, Inc. Flexible delivery system
US20030050682A1 (en) * 1999-08-09 2003-03-13 Sharkey Hugh R. Device for improving cardiac function
US6537300B2 (en) * 2001-05-30 2003-03-25 Scimed Life Systems, Inc. Implantable obstruction device for septal defects
US20030057156A1 (en) * 2001-03-08 2003-03-27 Dean Peterson Atrial filter implants
WO2003024337A1 (en) * 2001-09-20 2003-03-27 Boston Scientific Limited Method and apparatus for treating septal defects
US6544167B2 (en) 1998-05-01 2003-04-08 Correstore, Inc. Ventricular restoration patch
US6543452B1 (en) * 2000-11-16 2003-04-08 Medilyfe, Inc. Nasal intubation device and system for intubation
US6547806B1 (en) * 2000-02-04 2003-04-15 Ni Ding Vascular sealing device and method of use
US20030074012A1 (en) * 2000-10-10 2003-04-17 Coalescent Surgical, Inc. Minimally invasive annuloplasty procedure and apparatus
US20030070682A1 (en) * 2001-10-11 2003-04-17 Wilson Peter M. Bronchial flow control devices and methods of use
US20030070676A1 (en) * 1999-08-05 2003-04-17 Cooper Joel D. Conduits having distal cage structure for maintaining collateral channels in tissue and related methods
US6551344B2 (en) 2000-04-26 2003-04-22 Ev3 Inc. Septal defect occluder
US6551303B1 (en) 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US20030078500A1 (en) * 2000-05-09 2003-04-24 Rami Evron System and method for three-dimensional reconstruction of an artery
US20030078603A1 (en) * 1999-03-01 2003-04-24 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US20030105384A1 (en) * 1999-08-09 2003-06-05 Sharkey Hugh R. Method of improving cardiac function using a porous membrane
US6596012B2 (en) 2000-04-19 2003-07-22 Radi Medical Systems Ab Intra-arterial occluder
WO2003061481A1 (en) * 2002-01-23 2003-07-31 Cardia, Inc. Occlusion device with non-thrombogenic properties
US20030144695A1 (en) * 1999-09-13 2003-07-31 Mcguckin James F. Vascular hole closure device
US20030144694A1 (en) * 2002-01-14 2003-07-31 Nmt Medical, Inc. Patent foramen ovale (PFO) closure method and device
US20030153943A1 (en) * 2001-03-12 2003-08-14 Michael T. Anthony Don Vascular filter with improved strength and flexibility
US20030154988A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Intra-bronchial device that provides a medicant intra-bronchially to the patient
US20030158515A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20030181940A1 (en) * 2001-02-28 2003-09-25 Gregory Murphy Ventricular restoration shaping apparatus and method of use
US20030181945A1 (en) * 2002-03-15 2003-09-25 Nmt Medical, Inc. Coupling system useful in placement of implants
US20030181988A1 (en) * 2002-03-22 2003-09-25 Ethicon, Inc. Hernia repair device
US20030187498A1 (en) * 2002-03-28 2003-10-02 Medtronic Ave, Inc. Chamfered stent strut and method of making same
US20030183235A1 (en) * 2001-10-25 2003-10-02 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030191495A1 (en) * 2001-12-19 2003-10-09 Nmt Medical, Inc. Septal occluder and associated methods
US20030195385A1 (en) * 2002-04-16 2003-10-16 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030192551A1 (en) * 2000-03-04 2003-10-16 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20030195561A1 (en) * 2000-12-07 2003-10-16 Carley Michael T. Closure device and methods for making and using them
US20030199963A1 (en) * 2002-04-23 2003-10-23 Numed, Inc. System for implanting a replacement valve
US20030199923A1 (en) * 1998-11-06 2003-10-23 Ev3 Sunnyvale, Inc., A California Corporation Adjustable left atrial appendage implant deployment system
US20030208232A1 (en) * 2002-05-06 2003-11-06 Velocimed, L.L.C. PFO closure devices and related methods of use
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US20030216769A1 (en) * 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US6652556B1 (en) 1999-10-27 2003-11-25 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6652555B1 (en) 1999-10-27 2003-11-25 Atritech, Inc. Barrier device for covering the ostium of left atrial appendage
US6656219B1 (en) 1987-10-19 2003-12-02 Dominik M. Wiktor Intravascular stent
US20030225421A1 (en) * 2002-03-25 2003-12-04 Nmt Medical, Inc. Patent foramen ovale (PFO) closure clips
US20030228344A1 (en) * 2002-03-08 2003-12-11 Fields Antony J. Methods and devices for inducing collapse in lung regions fed by collateral pathways
WO2004012629A1 (en) * 1999-08-09 2004-02-12 Cardiokinetix, Inc. A device for improving cardiac function
US20040034366A1 (en) * 1999-11-08 2004-02-19 Ev3 Sunnyvale, Inc., A California Corporation Device for containing embolic material in the LAA having a plurality of tissue retention structures
US6695866B1 (en) * 1998-07-15 2004-02-24 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US20040039250A1 (en) * 2002-05-28 2004-02-26 David Tholfsen Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment
US20040044361A1 (en) * 1998-11-06 2004-03-04 Frazier Andrew G.C. Detachable atrial appendage occlusion balloon
US20040055606A1 (en) * 2001-03-02 2004-03-25 Emphasys Medical, Inc. Bronchial flow control devices with membrane seal
US20040060563A1 (en) * 2001-03-02 2004-04-01 Alan Rapacki Bronchial flow control devices and methods of use
US20040078053A1 (en) * 1998-01-30 2004-04-22 St. Jude Medical Atg, Inc. Medical graft connector or plug structures, and methods of making and installing same
US20040074491A1 (en) * 2001-03-02 2004-04-22 Michael Hendricksen Delivery methods and devices for implantable bronchial isolation devices
US20040087980A1 (en) * 2002-08-02 2004-05-06 Ford Steven Palmer Implantable prosthesis
US20040092973A1 (en) * 2002-09-23 2004-05-13 Nmt Medical, Inc. Septal puncture device
US20040092964A1 (en) * 1999-03-04 2004-05-13 Modesitt D. Bruce Articulating suturing device and method
US6736822B2 (en) * 2002-02-20 2004-05-18 Mcclellan Scott B. Device and method for internal ligation of tubular structures
US20040098044A1 (en) * 1989-05-29 2004-05-20 Van De Moer Wouter Matthijs Muijs Sealing device
US20040098031A1 (en) * 1998-11-06 2004-05-20 Van Der Burg Erik J. Method and device for left atrial appendage occlusion
US20040098121A1 (en) * 2002-11-07 2004-05-20 Nmt Medical, Inc. Patent foramen ovale (PFO) closure with magnetic force
US20040098042A1 (en) * 2002-06-03 2004-05-20 Devellian Carol A. Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof
US6749622B2 (en) 1999-09-13 2004-06-15 Rex Medical, L.P. Vascular closure
US20040116949A1 (en) * 2002-12-11 2004-06-17 Ewers Richard C. Apparatus and methods for forming gastrointestinal tissue approximations
US20040122456A1 (en) * 2002-12-11 2004-06-24 Saadat Vahid C. Methods and apparatus for gastric reduction
US20040127855A1 (en) * 2002-10-10 2004-07-01 Nmt Medical, Inc. Hemostasis valve
US20040127969A1 (en) * 1987-04-06 2004-07-01 Lazarus Harrison M. Artificial graft and implantation method
US20040133236A1 (en) * 2001-12-19 2004-07-08 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
US20040143277A1 (en) * 2003-01-22 2004-07-22 Marino Joseph A. Hoop design for occlusion device
US20040143291A1 (en) * 2003-01-22 2004-07-22 Cardia, Inc. Occlusion device having five or more arms
US20040143294A1 (en) * 2003-01-22 2004-07-22 Cardia, Inc. Septal stabilization device
US20040143292A1 (en) * 2003-01-22 2004-07-22 Marino Joseph A. Laminated sheets for use in a fully retrievable occlusion device
US20040143293A1 (en) * 2003-01-22 2004-07-22 Marino Joseph A. Articulated center post
US20040146296A1 (en) * 2002-06-06 2004-07-29 Irwin Gerszberg Integrated electrical/optical hybrid communication system with revertive hitless switch
US20040148035A1 (en) * 2002-11-27 2004-07-29 Michael Barrett Delivery methods and devices for implantable bronchial isolation devices
US20040167546A1 (en) * 2002-12-11 2004-08-26 Vahid Saadat Methods for reduction of a gastric lumen
EP1454587A2 (en) * 2003-03-06 2004-09-08 Aesculap AG & Co. KG Occlusion device for a puncture channel and applicator device
US20040176799A1 (en) * 2002-12-09 2004-09-09 Nmt Medical, Inc. Septal closure devices
US20040176788A1 (en) * 2003-03-07 2004-09-09 Nmt Medical, Inc. Vacuum attachment system
US6790213B2 (en) 2002-01-07 2004-09-14 C.R. Bard, Inc. Implantable prosthesis
US20040181237A1 (en) * 2003-03-12 2004-09-16 Sean Forde Medical device for manipulation of a medical implant
US20040186487A1 (en) * 1992-12-10 2004-09-23 Klein Enrique J. Device and method for suturing tissue
US20040200484A1 (en) * 2003-04-08 2004-10-14 Springmeyer Steven C. Bronchoscopic lung volume reduction method
US20040210307A1 (en) * 2003-04-18 2004-10-21 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
US20040210248A1 (en) * 2003-03-12 2004-10-21 Spiration, Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
US20040206349A1 (en) * 2001-09-11 2004-10-21 Alferness Clifton A. Removable lung reduction devices, systems, and methods
US20040215230A1 (en) * 2003-04-28 2004-10-28 Frazier Andrew G. C. Left atrial appendage occlusion device with active expansion
US20040220610A1 (en) * 1999-11-08 2004-11-04 Kreidler Marc S. Thin film composite lamination
US20040220596A1 (en) * 2003-02-04 2004-11-04 Frazier Andrew G.C. Patent foramen ovale closure system
US6814748B1 (en) 1995-06-07 2004-11-09 Endovascular Technologies, Inc. Intraluminal grafting system
US20040225324A1 (en) * 2003-05-08 2004-11-11 Marino Joseph A. Delivery system with safety tether
US20040225300A1 (en) * 1999-04-09 2004-11-11 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US20040230185A1 (en) * 2003-03-27 2004-11-18 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
WO2004100803A1 (en) * 2003-05-12 2004-11-25 Cardiokinetix, Inc. A system for improving cardiac function
US20040243170A1 (en) * 2001-09-05 2004-12-02 Mitta Suresh Method and device for percutaneous surgical ventricular repair
US20040243393A1 (en) * 2003-05-29 2004-12-02 Microsoft Corporation Semantic object synchronous understanding implemented with speech application language tags
US20040249408A1 (en) * 2001-09-05 2004-12-09 Chase Medical, Lp Method and device for endoscopic surgical ventricular repair
US20040267306A1 (en) * 2003-04-11 2004-12-30 Velocimed, L.L.C. Closure devices, related delivery methods, and related methods of use
US20040267191A1 (en) * 2003-03-27 2004-12-30 Cierra, Inc. Methods and apparatus for treatment of patent foramen ovale
US20050021016A1 (en) * 2003-03-27 2005-01-27 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US20050033326A1 (en) * 1999-09-13 2005-02-10 Briganti Richard T. Vascular hole closure device
US20050033327A1 (en) * 1999-09-07 2005-02-10 John Gainor Retrievable septal defect closure device
US20050033288A1 (en) * 2003-02-13 2005-02-10 Coaptus Medical Corporation Transseptal left atrial access and septal closure
US20050034735A1 (en) * 2003-03-27 2005-02-17 Cierra, Inc. Methods and apparatus for treatment of patent foramen ovale
US20050043759A1 (en) * 2003-07-14 2005-02-24 Nmt Medical, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US20050043751A1 (en) * 2001-09-04 2005-02-24 Broncus Technologies, Inc. Methods and devices for maintaining patency of surgically created channels in a body organ
US20050043752A1 (en) * 2001-09-04 2005-02-24 Broncus Technologies, Inc. Methods and devices for maintaining patency of surgically created channels in a body organ
US6860901B1 (en) 1988-03-09 2005-03-01 Endovascular Technologies, Inc. Intraluminal grafting system
US20050049681A1 (en) * 2003-05-19 2005-03-03 Secant Medical, Llc Tissue distention device and related methods for therapeutic intervention
US20050051163A1 (en) * 2000-03-04 2005-03-10 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20050060041A1 (en) * 2001-09-04 2005-03-17 Broncus Technologies, Inc. Methods and devices for maintaining surgically created channels in a body organ
US20050059984A1 (en) * 2003-09-11 2005-03-17 Andrzej Chanduszko Devices, systems, and methods for suturing tissue
US20050059983A1 (en) * 2003-09-11 2005-03-17 Nmt Medical, Inc. Suture sever tube
US20050065548A1 (en) * 2003-09-23 2005-03-24 Marino Joseph A. Right retrieval mechanism
US20050065546A1 (en) * 2003-09-18 2005-03-24 Cardia, Inc. Self centering closure device for septal occlusion
US20050070923A1 (en) * 2003-09-26 2005-03-31 Mcintosh Scott A. Device and method for suturing intracardiac defects
US20050075653A1 (en) * 1999-06-25 2005-04-07 Usgi Medical Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US20050080430A1 (en) * 2003-08-19 2005-04-14 Nmt Medical, Inc. Expandable sheath tubing
US20050080406A1 (en) * 2003-03-27 2005-04-14 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US20050113868A1 (en) * 2003-11-20 2005-05-26 Devellian Carol A. Device, with electrospun fabric, for a percutaneous transluminal procedure, and methods thereof
US20050113861A1 (en) * 2003-11-25 2005-05-26 Corcoran Michael P. Left atrial appendage closure device
US20050125032A1 (en) * 2003-10-10 2005-06-09 Whisenant Brian K. Patent foramen ovale (PFO) closure devices, delivery apparatus and related methods and systems
US20050131438A1 (en) * 2001-06-29 2005-06-16 Cohn William E. Method and apparatus for resecting and replacing an aortic valve
US20050137712A1 (en) * 2002-04-19 2005-06-23 Michael Biggs Devices for maintaining surgically created openings
US20050137698A1 (en) * 2003-12-23 2005-06-23 Amr Salahieh Leaflet engagement elements and methods for use thereof
US20050137693A1 (en) * 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US20050137694A1 (en) * 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US20050137691A1 (en) * 2003-12-23 2005-06-23 Sadra Medical Two piece heart valve and anchor
US20050137690A1 (en) * 2003-12-23 2005-06-23 Sadra Medical Low profile heart valve and delivery system
US20050137696A1 (en) * 2003-12-23 2005-06-23 Sadra Medical Apparatus and methods for protecting against embolization during endovascular heart valve replacement
US20050137702A1 (en) * 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US20050137714A1 (en) * 2003-08-08 2005-06-23 Gonzalez Hugo X. Bronchoscopic repair of air leaks in a lung
US20050143761A1 (en) * 1999-03-04 2005-06-30 Modesitt D. B. Articulating suturing device and method
US20050148925A1 (en) * 2001-04-20 2005-07-07 Dan Rottenberg Device and method for controlling in-vivo pressure
US20050154252A1 (en) * 2004-01-09 2005-07-14 Cardiokinetix, Inc. Ventricular partitioning device
US20050154321A1 (en) * 2004-01-13 2005-07-14 Remon Medical Technologies Ltd Devices for fixing a sendor in a lumen
US20050155612A1 (en) * 1999-09-20 2005-07-21 Nuvasive, Inc. Annulotomy closure device and related methods
US6923828B1 (en) 1987-10-19 2005-08-02 Medtronic, Inc. Intravascular stent
US20050171564A1 (en) * 2002-06-19 2005-08-04 Manzo Scott E. Method and apparatus for radical prostatectomy anastomosis
US20050178389A1 (en) * 2004-01-27 2005-08-18 Shaw David P. Disease indications for selective endobronchial lung region isolation
US20050187568A1 (en) * 2004-02-20 2005-08-25 Klenk Alan R. Devices and methods for closing a patent foramen ovale with a coil-shaped closure device
US20050192626A1 (en) * 2004-01-30 2005-09-01 Nmt Medical, Inc. Devices, systems, and methods for closure of cardiac openings
US20050192627A1 (en) * 2003-10-10 2005-09-01 Whisenant Brian K. Patent foramen ovale closure devices, delivery apparatus and related methods and systems
US20050192654A1 (en) * 2004-01-30 2005-09-01 Nmt Medical, Inc. Welding systems useful for closure of cardiac openings
US6939361B1 (en) 1999-09-22 2005-09-06 Nmt Medical, Inc. Guidewire for a free standing intervascular device having an integral stop mechanism
US20050197695A1 (en) * 2004-03-03 2005-09-08 Sorin Biomedica Cardio S.R.L. Minimally-invasive cardiac-valve prosthesis
US20050196344A1 (en) * 2004-02-27 2005-09-08 Mccutcheon John Methods and devices for blocking flow through collateral pathways in the lung
US20050197716A1 (en) * 2004-03-03 2005-09-08 Cardiokinetix, Inc. Inflatable ventricular partitioning device
US20050203500A1 (en) * 2004-03-09 2005-09-15 Usgi Medical Inc. Apparatus and methods for mapping out endoluminal gastrointestinal surgery
US20050203618A1 (en) * 2003-12-10 2005-09-15 Adam Sharkawy Prosthetic cardiac valves and systems and methods for implanting thereof
US20050203488A1 (en) * 2004-03-09 2005-09-15 Usgi Medical Inc. Apparatus and methods for mapping out endoluminal gastrointestinal surgery
US6949107B2 (en) 1999-09-13 2005-09-27 Rex Medical, Lp Injection method for locating vessel lumen
EP1582151A2 (en) * 1996-05-08 2005-10-05 Carag AG A device for plugging an opening in a wall of a hollow or tubular organ
US20050228283A1 (en) * 2003-06-10 2005-10-13 Gifford Hanson S Methods and apparatus for non-invasively treating atrial fibrillation using high intensity focused ultrasound
US20050228413A1 (en) * 2004-04-12 2005-10-13 Binmoeller Kenneth F Automated transluminal tissue targeting and anchoring devices and methods
US20050228434A1 (en) * 2004-03-19 2005-10-13 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
US20050245945A1 (en) * 1999-06-25 2005-11-03 Usgi Medical Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US20050250985A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Self-locking removable apparatus and methods for manipulating and securing tissue
US20050251154A1 (en) * 2004-05-06 2005-11-10 Nmt Medical, Inc. Double coil occluder
US20050251162A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Apparatus and methods for manipulating and securing tissue
US20050251176A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. System for treating gastroesophageal reflux disease
US20050251209A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Apparatus and methods for positioning and securing anchors
US20050251157A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Apparatus and methods for positioning and securing anchors
US20050251205A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Apparatus and methods for positioning and securing anchors
US20050251208A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Linear anchors for anchoring to tissue
US20050251189A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Multi-position tissue manipulation assembly
US20050251161A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Needle assembly for tissue manipulation
US20050251210A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Methods and apparatus for grasping and cinching tissue anchors
US20050251165A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Tissue manipulation and securement system
EP1595504A1 (en) * 2004-05-12 2005-11-16 Medtronic Vascular, Inc. Cardiovascular defect patch
US20050267523A1 (en) * 2004-03-03 2005-12-01 Nmt Medical Inc. Delivery/recovery system for septal occluder
US20050267525A1 (en) * 2004-04-26 2005-12-01 Nmt Medical, Inc. Heart-shaped PFO closure device
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US20050273124A1 (en) * 2004-05-06 2005-12-08 Nmt Medical, Inc. Delivery systems and methods for PFO closure device with two anchors
US20050273119A1 (en) * 2003-12-09 2005-12-08 Nmt Medical, Inc. Double spiral patent foramen ovale closure clamp
US20050273135A1 (en) * 2004-05-07 2005-12-08 Nmt Medical, Inc. Catching mechanisms for tubular septal occluder
US20050273136A1 (en) * 2000-01-05 2005-12-08 Integrated Vascular Systems, Inc. Apparatus and methods for delivering a closure device
US20050277981A1 (en) * 2004-06-09 2005-12-15 Usgi Medical Inc. Apparatus and methods for optimizing anchoring force
US20050277966A1 (en) * 2004-06-09 2005-12-15 Usgi Medical Inc. Compressible tissue anchor assemblies
US20050277983A1 (en) * 2004-06-09 2005-12-15 Usgi Medical Inc. System for optimizing anchoring force
US20050283231A1 (en) * 2004-06-16 2005-12-22 Haug Ulrich R Everting heart valve
US20050288786A1 (en) * 2004-05-07 2005-12-29 Nmt Medical, Inc. Closure device with hinges
US20050288706A1 (en) * 2004-05-07 2005-12-29 Nmt Medical, Inc. Inflatable occluder
US20060004305A1 (en) * 2002-11-27 2006-01-05 George Robert M Delivery methods and devices for implantable bronchial isolation devices
US20060009800A1 (en) * 2003-04-11 2006-01-12 Velocimed Pfo, Inc. Closure devices, related delivery methods, and related methods of use
US20060014998A1 (en) * 2002-08-01 2006-01-19 Sharkey Hugh R Multiple partitioning devices for heart treatment
US20060020270A1 (en) * 2003-01-30 2006-01-26 Ronald Jabba Clip applier and methods of use
US20060020276A1 (en) * 2004-07-23 2006-01-26 Usgi Medical Inc. Apparatus and methods for achieving prolonged maintenance of gastrointestinal tissue folds
US20060020347A1 (en) * 2004-03-08 2006-01-26 Michael Barrett Implanted bronchial isolation devices and methods
US20060030881A1 (en) * 2004-08-05 2006-02-09 Cardiokinetix, Inc. Ventricular partitioning device
US20060030863A1 (en) * 2004-07-21 2006-02-09 Fields Antony J Implanted bronchial isolation device delivery devices and methods
US20060058820A1 (en) * 2002-11-15 2006-03-16 Claude Mialhe Occlusive device for medical or surgical use
US20060074397A1 (en) * 2004-10-05 2006-04-06 Jin Shimada Devices and methods for access through a tissue wall
US20060074410A1 (en) * 2004-06-21 2006-04-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US20060079915A1 (en) * 2001-12-26 2006-04-13 Chin Albert K Temporary anastomotic seal and method
US20060106420A1 (en) * 2004-11-12 2006-05-18 Medtronic Vascular, Inc. Patch for treating a septal defect
US20060106447A1 (en) * 2004-01-26 2006-05-18 Nmt Medical, Inc. Adjustable stiffness medical system
US20060107956A1 (en) * 2004-11-19 2006-05-25 Hendricksen Michael J Bronchial flow control devices and methods of use
US20060116710A1 (en) * 2004-11-29 2006-06-01 Cardia, Inc. Self-centering occlusion device
US20060122647A1 (en) * 2004-09-24 2006-06-08 Callaghan David J Occluder device double securement system for delivery/recovery of such occluder device
US20060122646A1 (en) * 2004-12-08 2006-06-08 Cardia, Inc. Daisy design for occlusion device
US20060122522A1 (en) * 2004-12-03 2006-06-08 Abhi Chavan Devices and methods for positioning and anchoring implantable sensor devices
EP1671591A1 (en) 2004-12-17 2006-06-21 Terumo Kabushiki Kaisha Apparatus for closing an opening in a tissue
US20060135962A1 (en) * 2004-09-09 2006-06-22 Kick George F Expandable trans-septal sheath
US20060135971A1 (en) * 2004-05-07 2006-06-22 Usgi Medical Inc. System for treating gastroesophageal reflux disease
US20060142218A1 (en) * 2000-02-18 2006-06-29 Kunihiro Ohta Method of controlling telomere length
US20060155327A1 (en) * 1999-09-13 2006-07-13 Briganti Richard T Vascular hole closure device
US20060167494A1 (en) * 2005-01-21 2006-07-27 Loubert Suddaby Aneurysm repair method and apparatus
US20060173469A1 (en) * 2001-01-24 2006-08-03 Klein Enrique J Device and method for suturing of internal puncture sites
US20060200196A1 (en) * 2005-01-28 2006-09-07 Lifetech Scientific Inc. Heart Septal Defect Occlusion Devices With Adjustable Length Tether Adapting To The Unique Anatomy Of The Patient
US20060217762A1 (en) * 2004-06-09 2006-09-28 Usgi Medical, Inc. Compressible tissue anchor assemblies
US20060217760A1 (en) * 2005-03-17 2006-09-28 Widomski David R Multi-strand septal occluder
US20060217761A1 (en) * 2005-03-24 2006-09-28 Opolski Steven W Curved arm intracardiac occluder
US20060229491A1 (en) * 2002-08-01 2006-10-12 Cardiokinetix, Inc. Method for treating myocardial rupture
US20060235432A1 (en) * 2002-02-21 2006-10-19 Devore Lauri J Intra-bronchial obstructing device that controls biological interaction with the patient
US20060235376A1 (en) * 2003-02-04 2006-10-19 Cardiodex Ltd. Methods and apparatus for hemostasis following arterial catheterization
US20060241687A1 (en) * 2005-03-16 2006-10-26 Glaser Erik N Septal occluder with pivot arms and articulating joints
US20060241690A1 (en) * 2004-03-19 2006-10-26 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects and for occluding fluid flow through portions of the vasculature of the body
US20060241579A1 (en) * 2003-12-26 2006-10-26 Terumo Kabushiki Kaisha Tissue closure and tissue closing device
US20060247642A1 (en) * 2004-11-09 2006-11-02 Stone Kevin T Tissue fixation device
US20060259074A1 (en) * 2005-02-22 2006-11-16 Brian Kelleher Methods and devices for anchoring to soft tissue
US20060271089A1 (en) * 2005-04-11 2006-11-30 Cierra, Inc. Methods and apparatus to achieve a closure of a layered tissue defect
US7144410B2 (en) 2003-09-18 2006-12-05 Cardia Inc. ASD closure device with self centering arm network
US20060276839A1 (en) * 1999-09-13 2006-12-07 Rex Medical Septal defect closure device
US20060282087A1 (en) * 2005-06-09 2006-12-14 Binmoeller Kenneth F Methods and devices for endosonography-guided fundopexy
US20060281965A1 (en) * 2005-06-10 2006-12-14 Alexander Khairkhahan Peripheral seal for a ventricular partitioning device
US20060282161A1 (en) * 2003-06-20 2006-12-14 Medtronic Vascular, Inc. Valve annulus reduction system
US20060287673A1 (en) * 2005-04-29 2006-12-21 Zerusa Limited Interventional medical closure device
US20070005083A1 (en) * 1997-04-30 2007-01-04 Sabaratham Sabanathan Occlusion device
US20070010876A1 (en) * 2003-12-23 2007-01-11 Amr Salahieh Externally Expandable Heart Valve Anchor and Method
US20070010851A1 (en) * 2003-07-14 2007-01-11 Chanduszko Andrzej J Tubular patent foramen ovale (PFO) closure device with catch system
US7169164B2 (en) 2000-09-21 2007-01-30 Atritech, Inc. Apparatus for implanting devices in atrial appendages
US20070032820A1 (en) * 2005-06-02 2007-02-08 Chen Chao-Chin Patent foramen ovale closure device
US20070049967A1 (en) * 2005-08-24 2007-03-01 Sibbitt Wilmer L Jr Vascular closure methods and apparatuses
US20070055333A1 (en) * 2005-09-06 2007-03-08 Sean Forde Removable intracardiac RF device
US7189235B2 (en) 1999-10-20 2007-03-13 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
US20070060895A1 (en) * 2005-08-24 2007-03-15 Sibbitt Wilmer L Jr Vascular closure methods and apparatuses
US20070066993A1 (en) * 2005-09-16 2007-03-22 Kreidler Marc S Intracardiac cage and method of delivering same
US20070088388A1 (en) * 2005-09-19 2007-04-19 Opolski Steven W Delivery device for implant with dual attachment sites
WO2007059243A1 (en) * 2005-11-15 2007-05-24 Aoi Medical, Inc. Arterial closure button
US20070123852A1 (en) * 2003-03-27 2007-05-31 Cierra, Inc. Methods and apparatus for closing a layered tissue defect
US20070123934A1 (en) * 2005-09-26 2007-05-31 Whisenant Brian K Delivery system for patent foramen ovale closure device
US20070135842A1 (en) * 1991-10-22 2007-06-14 Kensey Nash Corporation Sealing device
US20070135825A1 (en) * 2005-06-09 2007-06-14 Binmoeller Kenneth F Methods and devices for anchoring to tissue
US20070135826A1 (en) * 2005-12-01 2007-06-14 Steve Zaver Method and apparatus for delivering an implant without bias to a left atrial appendage
US20070156205A1 (en) * 2006-01-05 2007-07-05 Larson Dennis E Implantable medical device with inductive coil configurable for mechanical fixation
US20070162107A1 (en) 2003-12-23 2007-07-12 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US20070161846A1 (en) * 1999-08-09 2007-07-12 Serjan Nikolic Cardiac device and methods of use thereof
US20070167981A1 (en) * 2005-12-22 2007-07-19 Nmt Medical, Inc. Catch members for occluder devices
US20070179527A1 (en) * 2006-02-02 2007-08-02 Boston Scientific Scimed, Inc. Occlusion apparatus, system, and method
US20070185530A1 (en) * 2005-09-01 2007-08-09 Chao Chin-Chen Patent foramen ovale closure method
US20070219630A1 (en) * 2004-11-24 2007-09-20 Xi Chu Devices and Methods for Beating Heart Cardiac Surgeries
US20070225759A1 (en) * 2006-03-22 2007-09-27 Daniel Thommen Method for delivering a medical device to the heart of a patient
US20070232992A1 (en) * 2006-03-31 2007-10-04 James Kutsko Articulable anchor
US20070239266A1 (en) * 2006-04-06 2007-10-11 Medtronic Vascular, Inc. Reinforced Surgical Conduit for Implantation of a Stented Valve Therein
US20070239271A1 (en) * 2006-04-10 2007-10-11 Than Nguyen Systems and methods for loading a prosthesis onto a minimally invasive delivery system
US20070239269A1 (en) * 2006-04-07 2007-10-11 Medtronic Vascular, Inc. Stented Valve Having Dull Struts
US20070239265A1 (en) * 2006-04-06 2007-10-11 Medtronic Vascular, Inc. Catheter Delivered Valve Having a Barrier to Provide an Enhanced Seal
US20070244545A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Prosthetic Conduit With Radiopaque Symmetry Indicators
US20070244494A1 (en) * 2006-04-18 2007-10-18 Downing Stephen W Methods and devices for treating atrial septal defects
US20070244544A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US20070244546A1 (en) * 2006-04-18 2007-10-18 Medtronic Vascular, Inc. Stent Foundation for Placement of a Stented Valve
US20070244517A1 (en) * 2006-03-31 2007-10-18 Nmt Medical, Inc. Deformable flap catch mechanism for occluder device
US20070255304A1 (en) * 2002-02-21 2007-11-01 Roschak Edmund J Devices for creating passages and sensing for blood vessels
US20070265656A1 (en) * 2004-03-19 2007-11-15 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
US20070270891A1 (en) * 2005-04-22 2007-11-22 Mcguckin James F Jr Closure device for left atrial appendage
US20070276415A1 (en) * 2006-03-31 2007-11-29 Nmt Medical, Inc. Screw catch mechanism for PFO occluder and method of use
US20070282430A1 (en) * 2004-02-04 2007-12-06 Daniel Thommen Implant For Occluding a Body Passage
US20070287886A1 (en) * 2005-02-02 2007-12-13 Voyage Medical Inc. Tissue visualization and manipulation systems
US20070293890A1 (en) * 2006-06-19 2007-12-20 Cardia, Inc. Occlusion device with flexible wire connector
US20070293889A1 (en) * 2006-06-19 2007-12-20 Cardia, Inc. Occlusion device with flexible fabric connector
US20070293891A1 (en) * 2006-06-19 2007-12-20 Cardia, Inc. Occlusion device with flexible polymeric connector
US20080009747A1 (en) * 2005-02-02 2008-01-10 Voyage Medical, Inc. Transmural subsurface interrogation and ablation
US20080027533A1 (en) * 2006-04-19 2008-01-31 Abbott Laboratories Dedicated bifurcation stent apparatus and method
US20080033290A1 (en) * 2005-10-25 2008-02-07 Voyage Medical, Inc. Delivery of biological compounds to ischemic and/or infarcted tissue
US20080039953A1 (en) * 2006-08-09 2008-02-14 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
WO2008019590A1 (en) * 2006-08-08 2008-02-21 Lifetech Scientific (Shenzhen) Co., Ltd Cardiac defect occlusion device
US20080058859A1 (en) * 2002-11-06 2008-03-06 Chanduszko Andrzej J Medical Devices Utilizing Modified Shape Memory Alloy
US20080065148A1 (en) * 2006-06-19 2008-03-13 Corcoran Michael P Occlusion device with flexible spring connector
US20080071178A1 (en) * 2006-09-15 2008-03-20 Cardiac Pacemakers, Inc. Anchor for an implantable sensor
US20080071339A1 (en) * 2006-09-15 2008-03-20 Cardiac Pacemakers, Inc. Mechanism for releasably engaging an implantable medical device for implantation
US20080071248A1 (en) * 2006-09-15 2008-03-20 Cardiac Pacemakers, Inc. Delivery stystem for an implantable physiologic sensor
US20080072914A1 (en) * 2006-08-25 2008-03-27 Hendricksen Michael J Bronchial Isolation Devices for Placement in Short Lumens
US20080082083A1 (en) * 2006-09-28 2008-04-03 Forde Sean T Perforated expandable implant recovery sheath
US20080086168A1 (en) * 2006-09-28 2008-04-10 Ryan Cahill Implant-catheter attachment mechanism using snare and method of use
US7361180B2 (en) 2004-05-07 2008-04-22 Usgi Medical, Inc. Apparatus for manipulating and securing tissue
US20080097476A1 (en) * 2006-09-01 2008-04-24 Voyage Medical, Inc. Precision control systems for tissue visualization and manipulation assemblies
US20080097354A1 (en) * 2006-08-29 2008-04-24 Francois Lavigne Stent for irrigation and delivery of medication
US20080108904A1 (en) * 2006-11-08 2008-05-08 Cardiac Pacemakers, Inc. Implant for securing a sensor in a vessel
US20080133003A1 (en) * 1999-11-17 2008-06-05 Jacques Seguin Prosthetic valve for transluminal delivery
US20080140069A1 (en) * 2006-12-07 2008-06-12 Cierra, Inc. Multi-electrode apparatus for tissue welding and ablation
US20080161825A1 (en) * 2006-11-20 2008-07-03 Stout Medical Group, L.P. Anatomical measurement tool
US20080167682A1 (en) * 2007-01-09 2008-07-10 Cardia, Inc. Bioabsorbable occlusion device
US20080188759A1 (en) * 2005-10-25 2008-08-07 Voyage Medical, Inc. Flow reduction hood systems
US7416554B2 (en) 2002-12-11 2008-08-26 Usgi Medical Inc Apparatus and methods for forming and securing gastrointestinal tissue folds
US7419498B2 (en) 2003-10-21 2008-09-02 Nmt Medical, Inc. Quick release knot attachment system
US20080215089A1 (en) * 2006-09-21 2008-09-04 Williams Michael S Stomach wall closure devices
US20080215086A1 (en) * 2006-09-29 2008-09-04 Daniel Olsen Single disc intraluminal fixation patent foramen ovale closure device
US20080214889A1 (en) * 2006-10-23 2008-09-04 Voyage Medical, Inc. Methods and apparatus for preventing tissue migration
US20080228200A1 (en) * 2007-03-16 2008-09-18 Clinton Baird Closure and reconstruction implants and the apparatus for delivery thereof
US20080243151A1 (en) * 2004-04-12 2008-10-02 Binmoeller Kenneth F Luminal Structure Anchoring Devices and Methods
US7431729B2 (en) 2002-06-05 2008-10-07 Nmt Medical, Inc. Patent foramen ovale (PFO) closure device with radial and circumferential support
US20080249562A1 (en) * 2007-04-05 2008-10-09 Nmt Medical, Inc. Septal closure device with centering mechanism
US20080275350A1 (en) * 2007-05-02 2008-11-06 Cardiac Pacemakers, Inc. System for anchoring an implantable sensor in a vessel
US20080287988A1 (en) * 2007-05-17 2008-11-20 Smith Paul J Tissue aperture securing and sealing apparatuses and related methods of use
US20080283066A1 (en) * 2007-05-17 2008-11-20 Cardiac Pacemakers, Inc. Delivery device for implantable sensors
US20080319254A1 (en) * 2002-08-01 2008-12-25 Cardiokinetix, Inc. Therapeutic methods and devices following myocardial infarction
US7473266B2 (en) 2003-03-14 2009-01-06 Nmt Medical, Inc. Collet-based delivery system
US20090030276A1 (en) * 2007-07-27 2009-01-29 Voyage Medical, Inc. Tissue visualization catheter with imaging systems integration
US20090030380A1 (en) * 2004-12-08 2009-01-29 Xlumena, Inc. Method and Apparatus for Performing Needle Guided Interventions
US20090025820A1 (en) * 2007-07-25 2009-01-29 Aga Medical Corporation Braided occlusion device having repeating expanded volume segments separated by articulation segments
US20090054723A1 (en) * 1999-08-09 2009-02-26 Alexander Khairkhahan Retrievable devices for improving cardiac function
US20090062841A1 (en) * 2004-03-19 2009-03-05 Aga Medical Corporation Device for occluding vascular defects
US20090082623A1 (en) * 2006-06-07 2009-03-26 Rothe Chris A Visualization and treatment via percutaneous methods and devices
US20090082804A1 (en) * 2005-03-29 2009-03-26 Terumo Kabushiki Kaisha Defect-Closure Device and Delivery Apparatus
US20090082803A1 (en) * 2007-09-26 2009-03-26 Aga Medical Corporation Braided vascular devices having no end clamps
US20090084386A1 (en) * 2007-10-01 2009-04-02 Mcclellan Annette M L Tubal ligation
US20090099530A1 (en) * 2007-10-12 2009-04-16 Martin Neal Adams Valve loader method, system, and apparatus
US20090112249A1 (en) * 2007-10-19 2009-04-30 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US20090112251A1 (en) * 2007-07-25 2009-04-30 Aga Medical Corporation Braided occlusion device having repeating expanded volume segments separated by articulation segments
US20090125119A1 (en) * 2007-11-13 2009-05-14 Obermiller F Joseph Fistula grafts and related methods and systems useful for treating gastrointestinal and other fistulae
US7547313B2 (en) 1998-06-03 2009-06-16 Medtronic, Inc. Tissue connector apparatus and methods
US20090163934A1 (en) * 1999-04-09 2009-06-25 Evalve, Inc. Detachment mechanism for implantable fixation devices
US20090171386A1 (en) * 2007-12-28 2009-07-02 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US20090182200A1 (en) * 2008-01-14 2009-07-16 Boston Scientific Scimed, Inc. Medical device
USRE40863E1 (en) * 1992-04-23 2009-07-21 Boston Scientific Scimed, Inc. Apparatus and method for sealing vascular punctures
US20090187074A1 (en) * 2008-01-17 2009-07-23 Nidus Medical, Llc Epicardial access and treatment systems
US20090187213A1 (en) * 2007-07-13 2009-07-23 Mcguckin Jr James F Vascular hole closure device
US20090192591A1 (en) * 2008-01-24 2009-07-30 Medtronic, Inc. Markers for Prosthetic Heart Valves
US7569062B1 (en) * 1998-07-15 2009-08-04 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US20090210048A1 (en) * 2008-02-18 2009-08-20 Aga Medical Corporation Stent/stent graft for reinforcement of vascular abnormalities and associated method
US20090227999A1 (en) * 2007-05-11 2009-09-10 Voyage Medical, Inc. Visual electrode ablation systems
US7591848B2 (en) 2006-04-06 2009-09-22 Medtronic Vascular, Inc. Riveted stent valve for percutaneous use
US20090254195A1 (en) * 1999-08-09 2009-10-08 Alexander Khairkhahan System for improving cardiac function by sealing a partitioning membrane within a ventricle
US7601159B2 (en) 2004-05-07 2009-10-13 Usgi Medical, Inc. Interlocking tissue anchor apparatus and methods
US7608098B1 (en) 2004-11-09 2009-10-27 Biomet Sports Medicine, Llc Bone fixation device
US20090270840A1 (en) * 2008-03-28 2009-10-29 Coherex Medical, Inc. Delivery systems for a medical device and related methods
US7611535B2 (en) 2001-09-07 2009-11-03 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US20090275974A1 (en) * 2008-05-02 2009-11-05 Philippe Marchand Filamentary devices for treatment of vascular defects
US20090275799A1 (en) * 2006-12-21 2009-11-05 Voyage Medical, Inc. Axial visualization systems
US7615076B2 (en) 1999-10-20 2009-11-10 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US20090281379A1 (en) * 2008-05-12 2009-11-12 Xlumena, Inc. System and method for transluminal access
US20090281557A1 (en) * 2008-05-12 2009-11-12 Xlumena, Inc. Tissue anchor for securing tissue layers
US20090287296A1 (en) * 2008-05-16 2009-11-19 Sorin Biomedica Cardio S.R.L. Atraumatic prosthetic heart valve prosthesis
US20090287040A1 (en) * 2005-06-10 2009-11-19 Alexander Khairkhahan Peripheral seal for a ventricular partitioning device
US7625403B2 (en) 2006-04-04 2009-12-01 Medtronic Vascular, Inc. Valved conduit designed for subsequent catheter delivered valve therapy
US20090312789A1 (en) * 2005-07-29 2009-12-17 Kassab Ghassan S Magnetic devices and methods for septal occlusion
US20090326578A1 (en) * 2004-09-30 2009-12-31 Usgi Medical, Inc. Interlocking tissue anchor apparatus and methods
US20100004679A1 (en) * 2006-09-25 2010-01-07 Peter Osypka Stiftung Stiftung Des Burgerlichen Rechts Medical device
US20100016840A1 (en) * 2008-07-15 2010-01-21 Stahmann Jeffrey E Implant assist apparatus for acoustically enabled implantable medical device
US20100016885A1 (en) * 2008-07-21 2010-01-21 Eidenschink Tracee E J Device to close openings in body tissue
US20100030246A1 (en) * 2007-02-01 2010-02-04 Dusan Pavcnik Closure Device and Method For Occluding a Bodily Passageway
US20100030193A1 (en) * 2003-04-04 2010-02-04 Minnesota Medtec, Inc. Guide catheter and method of making same
US7658196B2 (en) 2005-02-24 2010-02-09 Ethicon Endo-Surgery, Inc. System and method for determining implanted device orientation
US7658751B2 (en) 2006-09-29 2010-02-09 Biomet Sports Medicine, Llc Method for implanting soft tissue
US20100036475A1 (en) * 2006-04-27 2010-02-11 Wilifrido Castaneda Methods and apparatus for extraluminal femoropopliteal bypass graft
US7666203B2 (en) 2003-11-06 2010-02-23 Nmt Medical, Inc. Transseptal puncture apparatus
US20100057115A1 (en) * 2005-09-20 2010-03-04 Rao Rob K Surgical method and clamping apparatus for repair of a defect in a dural membrane or a vascular wall, and anastomic method and apparatus for a body
US20100057192A1 (en) * 2006-11-07 2010-03-04 David Stephen Celermajer Devices and methods for the treatment of heart failure
US7678132B2 (en) * 2001-09-06 2010-03-16 Ovalis, Inc. Systems and methods for treating septal defects
US20100069948A1 (en) * 2008-09-12 2010-03-18 Micrus Endovascular Corporation Self-expandable aneurysm filling device, system and method of placement
US7682390B2 (en) 2001-07-31 2010-03-23 Medtronic, Inc. Assembly for setting a valve prosthesis in a corporeal duct
US20100094081A1 (en) * 2008-10-10 2010-04-15 Voyage Medical, Inc. Electrode placement and connection systems
US20100100107A1 (en) * 2008-10-20 2010-04-22 IMDS, Inc. Systems and methods for cerebrospinal fluid repair
US7704269B2 (en) 1999-04-09 2010-04-27 Evalve, Inc. Methods and apparatus for cardiac valve repair
US20100114159A1 (en) * 2008-10-30 2010-05-06 Abbott Vascular Inc. Closure device
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
US7735493B2 (en) 2003-08-15 2010-06-15 Atritech, Inc. System and method for delivering a left atrial appendage containment device
US7736388B2 (en) 1999-04-09 2010-06-15 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US7740640B2 (en) 2001-09-06 2010-06-22 Ovalis, Inc. Clip apparatus for closing septal defects and methods of use
US7744611B2 (en) 2000-10-10 2010-06-29 Medtronic, Inc. Minimally invasive valve repair procedure and apparatus
US7749250B2 (en) 2006-02-03 2010-07-06 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US20100179566A1 (en) * 2008-07-01 2010-07-15 Boris Reydel Dissecting-swatting surgical stapling device and methods of use
US7758606B2 (en) 2000-06-30 2010-07-20 Medtronic, Inc. Intravascular filter with debris entrapment mechanism
US20100185233A1 (en) * 2006-08-22 2010-07-22 Carag Ag Occluding Device
US7763040B2 (en) 1998-06-03 2010-07-27 Medtronic, Inc. Tissue connector apparatus and methods
US7766820B2 (en) 2002-10-25 2010-08-03 Nmt Medical, Inc. Expandable sheath tubing
US7775215B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. System and method for determining implanted device positioning and obtaining pressure data
US7775966B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. Non-invasive pressure measurement in a fluid adjustable restrictive device
US7780726B2 (en) 2001-07-04 2010-08-24 Medtronic, Inc. Assembly for placing a prosthetic valve in a duct in the body
US20100228337A1 (en) * 2009-03-04 2010-09-09 Abbott Laboratories Vascular Enterprises Limited Mirror image stent and method of use
US20100228279A1 (en) * 2009-01-08 2010-09-09 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US20100228241A1 (en) * 2003-02-04 2010-09-09 Cardiodex Ltd. Methods and apparatus for hemostasis following arterial catheterization
US20100234878A1 (en) * 2009-03-16 2010-09-16 Cook Incorporated Closure device with string retractable umbrella
US7806904B2 (en) 2000-12-07 2010-10-05 Integrated Vascular Systems, Inc. Closure device
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US20100262167A1 (en) * 2009-04-09 2010-10-14 Medtronic, Inc. Medical Clip with Radial Tines, System and Method of Using Same
US20100262140A1 (en) * 2008-10-10 2010-10-14 Voyage Medical, Inc. Integral electrode placement and connection systems
US20100268029A1 (en) * 2009-04-21 2010-10-21 Xlumena, Inc. Methods and apparatus for advancing a device from one body lumen to another
US20100268175A1 (en) * 2009-04-21 2010-10-21 Xlumena, Inc. System and method for delivering expanding trocar through a sheath
US7819895B2 (en) 2000-01-05 2010-10-26 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US20100274227A1 (en) * 2009-02-13 2010-10-28 Alexander Khairkhahan Delivery catheter handle cover
US20100274351A1 (en) * 2009-04-27 2010-10-28 Sorin Biomedica Cardio S.R.I. Prosthetic vascular conduit
US20100274267A1 (en) * 2009-04-24 2010-10-28 Medtronics, Inc. Medical Clip with Tines, System and Method of Using Same
US7824442B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
US7828850B2 (en) 1999-10-20 2010-11-09 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US7842068B2 (en) 2000-12-07 2010-11-30 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US7841502B2 (en) 2007-12-18 2010-11-30 Abbott Laboratories Modular clip applier
US7842049B2 (en) 2002-12-31 2010-11-30 Abbott Laboratories Systems for anchoring a medical device in a body lumen
US7842048B2 (en) 2006-08-18 2010-11-30 Abbott Laboratories Articulating suture device and method
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
US7846170B2 (en) 1999-03-04 2010-12-07 Abbott Laboratories Articulating suturing device and method
US7850709B2 (en) 2002-06-04 2010-12-14 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US7850797B2 (en) 2002-12-31 2010-12-14 Integrated Vascular Systems, Inc. Methods for manufacturing a clip and clip
US20100324595A1 (en) * 2006-08-09 2010-12-23 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US20100324587A1 (en) * 2009-06-17 2010-12-23 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US7857830B2 (en) 2006-02-03 2010-12-28 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US7867249B2 (en) 2003-01-30 2011-01-11 Integrated Vascular Systems, Inc. Clip applier and methods of use
US20110009901A1 (en) * 2009-07-13 2011-01-13 Tom Holman Metal vascular aperture closure device
US20110017207A1 (en) * 2001-03-02 2011-01-27 Pulmonx Corporation Bronchial flow control devices with membrane seal
US7879047B2 (en) 2003-12-10 2011-02-01 Medtronic, Inc. Surgical connection apparatus and methods
US20110029013A1 (en) * 2008-02-15 2011-02-03 Mcguckin James F Vascular Hole Closure Device
US7883517B2 (en) 2005-08-08 2011-02-08 Abbott Laboratories Vascular suturing device
US7887563B2 (en) 2001-06-07 2011-02-15 Abbott Vascular Inc. Surgical staple
US7896892B2 (en) 2000-03-31 2011-03-01 Medtronic, Inc. Multiple bias surgical fastener
US7905903B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Method for tissue fixation
US7905904B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US20110066180A1 (en) * 2005-01-28 2011-03-17 Weijun Zeng Heart septal defect occlusion device
US7909851B2 (en) 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US20110071624A1 (en) * 2006-11-07 2011-03-24 Dc Devices, Inc. Devices for retrieving a prosthesis
US7914539B2 (en) 2004-11-09 2011-03-29 Biomet Sports Medicine, Llc Tissue fixation device
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
US7918869B2 (en) 2004-05-07 2011-04-05 Usgi Medical, Inc. Methods and apparatus for performing endoluminal gastroplasty
US7918845B2 (en) 2003-01-15 2011-04-05 Usgi Medical, Inc. Endoluminal tool deployment system
US7922768B2 (en) 1999-10-20 2011-04-12 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and deformable spinal disc annulus stent
US20110087272A1 (en) * 2009-10-08 2011-04-14 Timothy Sargeant Wound Closure Device
US20110087066A1 (en) * 2000-08-09 2011-04-14 Boutillette Michael P Devices and methods for delivering an endocardial device
US7930016B1 (en) 2005-02-02 2011-04-19 Voyage Medical, Inc. Tissue closure system
US7927270B2 (en) 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
US7931669B2 (en) 2000-01-05 2011-04-26 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US7935147B2 (en) 1999-10-20 2011-05-03 Anulex Technologies, Inc. Method and apparatus for enhanced delivery of treatment device to the intervertebral disc annulus
US7938840B2 (en) 1999-04-05 2011-05-10 Medtronic, Inc. Apparatus and methods for anastomosis
US20110112622A1 (en) * 2009-05-29 2011-05-12 Xlumena, Inc. Apparatus and method for deploying stent across adjacent tissue layers
US7942898B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Delivery systems and methods for gastric reduction
US7951201B2 (en) 1999-10-20 2011-05-31 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US7955340B2 (en) 1999-06-25 2011-06-07 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7959650B2 (en) 2006-09-29 2011-06-14 Biomet Sports Medicine, Llc Adjustable knotless loops
US7959672B2 (en) 2003-12-23 2011-06-14 Sadra Medical Replacement valve and anchor
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7963973B2 (en) 1998-06-03 2011-06-21 Medtronic, Inc. Multiple loop tissue connector apparatus and methods
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7972378B2 (en) 2008-01-24 2011-07-05 Medtronic, Inc. Stents for prosthetic heart valves
US7976556B2 (en) 2002-09-12 2011-07-12 Medtronic, Inc. Anastomosis apparatus and methods
US7981123B2 (en) 1997-09-12 2011-07-19 Evalve, Inc. Surgical device for connecting soft tissue
US7981139B2 (en) 2002-03-01 2011-07-19 Evalve, Inc Suture anchors and methods of use
US20110184439A1 (en) * 2008-05-09 2011-07-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biological Matrix for Cardiac Repair
US7988724B2 (en) 2003-12-23 2011-08-02 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US20110190874A1 (en) * 2010-01-29 2011-08-04 Dc Devices, Inc. Devices and methods for reducing venous pressure
US8007512B2 (en) 2002-02-21 2011-08-30 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8016745B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. Monitoring of a food intake restriction device
US8016744B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US8021385B2 (en) 2002-03-20 2011-09-20 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20110226238A1 (en) * 2000-03-04 2011-09-22 Pulmonx Corporation Implanted bronchial isolation devices and methods
US8029519B2 (en) 2003-08-22 2011-10-04 Medtronic, Inc. Eversion apparatus and methods
US8034065B2 (en) 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8034061B2 (en) 2007-07-12 2011-10-11 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US8038688B2 (en) 1999-03-04 2011-10-18 Abbott Laboratories Articulating suturing device and method
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US20110264208A1 (en) * 2010-04-27 2011-10-27 Medtronic, Inc. Prosthetic Heart Valve Devices and Methods of Valve Repair
US8050746B2 (en) 2005-02-02 2011-11-01 Voyage Medical, Inc. Tissue visualization device and method variations
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
US8052749B2 (en) 2003-12-23 2011-11-08 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US8052750B2 (en) 2006-09-19 2011-11-08 Medtronic Ventor Technologies Ltd Valve prosthesis fixation techniques using sandwiching
US8057511B2 (en) 2004-05-07 2011-11-15 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US8057492B2 (en) 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US8066629B2 (en) 2005-02-24 2011-11-29 Ethicon Endo-Surgery, Inc. Apparatus for adjustment and sensing of gastric band pressure
US8070772B2 (en) 2008-02-15 2011-12-06 Rex Medical, L.P. Vascular hole closure device
US8070826B2 (en) 2001-09-07 2011-12-06 Ovalis, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US8075615B2 (en) 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US8083754B2 (en) 2005-08-08 2011-12-27 Abbott Laboratories Vascular suturing device with needle capture
US8088130B2 (en) 2006-02-03 2012-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8100870B2 (en) 2007-12-14 2012-01-24 Ethicon Endo-Surgery, Inc. Adjustable height gastric restriction devices and methods
US8105345B2 (en) 2002-10-04 2012-01-31 Medtronic, Inc. Anastomosis apparatus and methods
US8114345B2 (en) 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
US8118822B2 (en) 1999-03-01 2012-02-21 Medtronic, Inc. Bridge clip tissue connector apparatus and methods
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8123703B2 (en) 1999-04-09 2012-02-28 Evalve, Inc. Steerable access sheath and methods of use
US8128698B2 (en) 1999-10-20 2012-03-06 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US8131350B2 (en) 2006-12-21 2012-03-06 Voyage Medical, Inc. Stabilization of visualization catheters
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8137364B2 (en) 2003-09-11 2012-03-20 Abbott Laboratories Articulating suturing device and method
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8142452B2 (en) 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8152710B2 (en) 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
US8157852B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US8163022B2 (en) 2008-10-14 2012-04-24 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US8167894B2 (en) 2006-08-09 2012-05-01 Coherex Medical, Inc. Methods, systems and devices for reducing the size of an internal tissue opening
US8177836B2 (en) 2008-03-10 2012-05-15 Medtronic, Inc. Apparatus and methods for minimally invasive valve repair
US8187163B2 (en) 2007-12-10 2012-05-29 Ethicon Endo-Surgery, Inc. Methods for implanting a gastric restriction device
US8187162B2 (en) 2008-03-06 2012-05-29 Ethicon Endo-Surgery, Inc. Reorientation port
US8192350B2 (en) 2008-01-28 2012-06-05 Ethicon Endo-Surgery, Inc. Methods and devices for measuring impedance in a gastric restriction system
US8202293B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8211124B2 (en) 2003-07-25 2012-07-03 Medtronic, Inc. Sealing clip, delivery systems, and methods
US8216230B2 (en) 2001-11-15 2012-07-10 Evalve, Inc. Cardiac valve leaflet attachment device and methods thereof
US8216252B2 (en) 2004-05-07 2012-07-10 Usgi Medical, Inc. Tissue manipulation and securement system
US8221439B2 (en) 2008-02-07 2012-07-17 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using kinetic motion
US8221310B2 (en) 2005-10-25 2012-07-17 Voyage Medical, Inc. Tissue visualization device and method variations
US8221454B2 (en) 2004-02-20 2012-07-17 Biomet Sports Medicine, Llc Apparatus for performing meniscus repair
US8226681B2 (en) 2007-06-25 2012-07-24 Abbott Laboratories Methods, devices, and apparatus for managing access through tissue
US8233995B2 (en) 2008-03-06 2012-07-31 Ethicon Endo-Surgery, Inc. System and method of aligning an implantable antenna
US8235985B2 (en) 2007-08-31 2012-08-07 Voyage Medical, Inc. Visualization and ablation system variations
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US8251998B2 (en) 2006-08-16 2012-08-28 Biomet Sports Medicine, Llc Chondral defect repair
US8267947B2 (en) 2005-08-08 2012-09-18 Abbott Laboratories Vascular suturing device
US8277480B2 (en) 2005-03-18 2012-10-02 W.L. Gore & Associates, Inc. Catch member for PFO occluder
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US8292910B2 (en) 2003-11-06 2012-10-23 Pressure Products Medical Supplies, Inc. Transseptal puncture apparatus
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US8298291B2 (en) 2005-05-26 2012-10-30 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
WO2012148696A1 (en) * 2011-04-28 2012-11-01 Cardiotulip Llc Devices for closure of a patent foramen ovale
US8303624B2 (en) 2010-03-15 2012-11-06 Abbott Cardiovascular Systems, Inc. Bioabsorbable plug
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8313497B2 (en) 2005-07-01 2012-11-20 Abbott Laboratories Clip applier and methods of use
US8313505B2 (en) 2004-03-19 2012-11-20 Aga Medical Corporation Device for occluding vascular defects
EP2524653A1 (en) 2011-05-17 2012-11-21 Carag AG Occluder
US8317825B2 (en) 2004-11-09 2012-11-27 Biomet Sports Medicine, Llc Soft tissue conduit device and method
US8323312B2 (en) 2008-12-22 2012-12-04 Abbott Laboratories Closure device
US8328868B2 (en) 2004-11-05 2012-12-11 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
US8337389B2 (en) 2008-01-28 2012-12-25 Ethicon Endo-Surgery, Inc. Methods and devices for diagnosing performance of a gastric restriction system
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US8343174B2 (en) 1999-04-09 2013-01-01 Evalve, Inc. Locking mechanisms for fixation devices and methods of engaging tissue
US8343227B2 (en) 2009-05-28 2013-01-01 Biomet Manufacturing Corp. Knee prosthesis assembly with ligament link
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8366706B2 (en) 2007-08-15 2013-02-05 Cardiodex, Ltd. Systems and methods for puncture closure
US8366741B2 (en) 2007-09-13 2013-02-05 Cardia, Inc. Occlusion device with centering arm
US8377079B2 (en) 2007-12-27 2013-02-19 Ethicon Endo-Surgery, Inc. Constant force mechanisms for regulating restriction devices
US8394114B2 (en) 2003-09-26 2013-03-12 Medtronic, Inc. Surgical connection apparatus and methods
US8398672B2 (en) 2003-11-12 2013-03-19 Nitinol Devices And Components, Inc. Method for anchoring a medical device
US8398656B2 (en) 2003-01-30 2013-03-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8409167B2 (en) 2004-07-19 2013-04-02 Broncus Medical Inc Devices for delivering substances through an extra-anatomic opening created in an airway
US8419753B2 (en) 2003-12-23 2013-04-16 Abbott Laboratories Suturing device with split arm and method of suturing tissue
US8430927B2 (en) 2008-04-08 2013-04-30 Medtronic, Inc. Multiple orifice implantable heart valve and methods of implantation
US20130110228A1 (en) * 2007-06-08 2013-05-02 St. Jude Medical, Inc Devices for transcatheter prosthetic heart valve implantation and access closure
US8435236B2 (en) 2004-11-22 2013-05-07 Cardiodex, Ltd. Techniques for heat-treating varicose veins
US8444657B2 (en) 2004-05-07 2013-05-21 Usgi Medical, Inc. Apparatus and methods for rapid deployment of tissue anchors
US8454652B1 (en) * 2002-10-29 2013-06-04 Adam L. Cohen Releasable tissue anchoring device, methods for using, and methods for making
US8491629B2 (en) 2008-02-15 2013-07-23 Rex Medical Vascular hole closure delivery device
US20130190811A1 (en) * 2005-09-01 2013-07-25 Cordis Corporation Single disc occlusionary patent foramen ovale closure device
US8500818B2 (en) 2006-09-29 2013-08-06 Biomet Manufacturing, Llc Knee prosthesis assembly with ligament link
US8506597B2 (en) 2011-10-25 2013-08-13 Biomet Sports Medicine, Llc Method and apparatus for interosseous membrane reconstruction
US8518063B2 (en) 2001-04-24 2013-08-27 Russell A. Houser Arteriotomy closure devices and techniques
US8529583B1 (en) 1999-09-03 2013-09-10 Medtronic, Inc. Surgical clip removal apparatus
US8540768B2 (en) 2005-02-10 2013-09-24 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US8556977B2 (en) 1999-10-20 2013-10-15 Anulex Technologies, Inc. Tissue anchoring system and method
US8556930B2 (en) 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US8556932B2 (en) 2011-05-19 2013-10-15 Abbott Cardiovascular Systems, Inc. Collapsible plug for tissue closure
US8562672B2 (en) 2004-11-19 2013-10-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US8574235B2 (en) 2006-02-03 2013-11-05 Biomet Sports Medicine, Llc Method for trochanteric reattachment
US8574244B2 (en) 2007-06-25 2013-11-05 Abbott Laboratories System for closing a puncture in a vessel wall
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US8579936B2 (en) 2005-07-05 2013-11-12 ProMed, Inc. Centering of delivery devices with respect to a septal defect
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8590760B2 (en) 2004-05-25 2013-11-26 Abbott Vascular Inc. Surgical stapler
US8591532B2 (en) 2008-02-12 2013-11-26 Ethicon Endo-Sugery, Inc. Automatically adjusting band system
US8591570B2 (en) 2004-09-07 2013-11-26 Medtronic, Inc. Prosthetic heart valve for replacing previously implanted heart valve
US8591395B2 (en) 2008-01-28 2013-11-26 Ethicon Endo-Surgery, Inc. Gastric restriction device data handling devices and methods
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US8603116B2 (en) 2010-08-04 2013-12-10 Abbott Cardiovascular Systems, Inc. Closure device with long tines
US8617184B2 (en) 2011-02-15 2013-12-31 Abbott Cardiovascular Systems, Inc. Vessel closure system
US8623077B2 (en) 2001-06-29 2014-01-07 Medtronic, Inc. Apparatus for replacing a cardiac valve
US8652172B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US8652204B2 (en) 2010-04-01 2014-02-18 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
CN103596508A (en) * 2011-01-11 2014-02-19 阿姆泽尔医药公司 Method and apparatus for treating varicose veins
US8657805B2 (en) 2007-05-08 2014-02-25 Intuitive Surgical Operations, Inc. Complex shape steerable tissue visualization and manipulation catheter
US8663252B2 (en) 2010-09-01 2014-03-04 Abbott Cardiovascular Systems, Inc. Suturing devices and methods
US8672953B2 (en) 2007-12-17 2014-03-18 Abbott Laboratories Tissue closure system and methods of use
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
US8685084B2 (en) 2011-12-29 2014-04-01 Sorin Group Italia S.R.L. Prosthetic vascular conduit and assembly method
US8694071B2 (en) 2010-02-12 2014-04-08 Intuitive Surgical Operations, Inc. Image stabilization techniques and methods
US8694129B2 (en) 2009-02-13 2014-04-08 Cardiac Pacemakers, Inc. Deployable sensor platform on the lead system of an implantable device
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8696611B2 (en) 2009-05-04 2014-04-15 V-Wave Ltd. Device and method for regulating pressure in a heart chamber
US20140114346A1 (en) * 2012-10-23 2014-04-24 Medtronic, Inc. Transapical Entry Point Closure Device
US8709034B2 (en) 2011-05-13 2014-04-29 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
US8728155B2 (en) 2011-03-21 2014-05-20 Cephea Valve Technologies, Inc. Disk-based valve apparatus and method for the treatment of valve dysfunction
US8726909B2 (en) 2006-01-27 2014-05-20 Usgi Medical, Inc. Methods and apparatus for revision of obesity procedures
WO2014078078A1 (en) * 2012-11-16 2014-05-22 W. L. Gore & Associates, Inc. Join assembly for medical devices
US8747458B2 (en) 2007-08-20 2014-06-10 Medtronic Ventor Technologies Ltd. Stent loading tool and method for use thereof
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US20140179993A1 (en) * 1999-08-09 2014-06-26 Miles D. Alexander Systems and methods for improving cardiac function
US8771352B2 (en) 2011-05-17 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US8771302B2 (en) 2001-06-29 2014-07-08 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US8784447B2 (en) 2000-09-08 2014-07-22 Abbott Vascular Inc. Surgical stapler
US8790242B2 (en) 2009-10-26 2014-07-29 Cardiokinetix, Inc. Ventricular volume reduction
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US8801746B1 (en) 2004-05-04 2014-08-12 Covidien Lp System and method for delivering a left atrial appendage containment device
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US8834563B2 (en) 2008-12-23 2014-09-16 Sorin Group Italia S.R.L. Expandable prosthetic valve having anchoring appendages
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US8858573B2 (en) 2012-04-10 2014-10-14 Abbott Cardiovascular Systems, Inc. Apparatus and method for suturing body lumens
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US8858609B2 (en) 2008-02-07 2014-10-14 Intuitive Surgical Operations, Inc. Stent delivery under direct visualization
US8864778B2 (en) 2012-04-10 2014-10-21 Abbott Cardiovascular Systems, Inc. Apparatus and method for suturing body lumens
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
US8870916B2 (en) 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger
US8876791B2 (en) 2005-02-25 2014-11-04 Pulmonx Corporation Collateral pathway treatment using agent entrained by aspiration flow current
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US8920463B2 (en) 2008-02-15 2014-12-30 Rex Medical, L.P. Vascular hole closure device
US8920462B2 (en) 2008-02-15 2014-12-30 Rex Medical, L.P. Vascular hole closure device
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US8934962B2 (en) 2005-02-02 2015-01-13 Intuitive Surgical Operations, Inc. Electrophysiology mapping and visualization system
US8936621B2 (en) 2006-02-03 2015-01-20 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8940014B2 (en) 2011-11-15 2015-01-27 Boston Scientific Scimed, Inc. Bond between components of a medical device
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
US8961541B2 (en) 2007-12-03 2015-02-24 Cardio Vascular Technologies Inc. Vascular closure devices, systems, and methods of use
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
US8992567B1 (en) 2001-04-24 2015-03-31 Cardiovascular Technologies Inc. Compressible, deformable, or deflectable tissue closure devices and method of manufacture
US8998981B2 (en) 2008-09-15 2015-04-07 Medtronic, Inc. Prosthetic heart valve having identifiers for aiding in radiographic positioning
US8998976B2 (en) 2011-07-12 2015-04-07 Boston Scientific Scimed, Inc. Coupling system for medical devices
US8998949B2 (en) 2004-11-09 2015-04-07 Biomet Sports Medicine, Llc Soft tissue conduit device
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US9034034B2 (en) 2010-12-22 2015-05-19 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
US20150157442A1 (en) * 1999-08-27 2015-06-11 Covidien Lp Slideable vascular filter
US9055906B2 (en) 2006-06-14 2015-06-16 Intuitive Surgical Operations, Inc. In-vivo visualization systems
US20150164512A1 (en) * 1997-07-10 2015-06-18 Stryker Corporation Methods and devices for the treatment of aneurysms
US9060858B2 (en) 2009-09-15 2015-06-23 Evalve, Inc. Methods, systems and devices for cardiac valve repair
US9060751B2 (en) 2010-12-30 2015-06-23 Vivasure Medical Limited Surgical closure systems and methods
US9072586B2 (en) 2008-10-03 2015-07-07 C.R. Bard, Inc. Implantable prosthesis
US9078781B2 (en) 2006-01-11 2015-07-14 Medtronic, Inc. Sterile cover for compressible stents used in percutaneous device delivery systems
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US9078658B2 (en) 2013-08-16 2015-07-14 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US20150196300A1 (en) * 2014-01-16 2015-07-16 Boston Scientific Scimed Inc. Retrieval wire centering device
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US9089674B2 (en) 2000-10-06 2015-07-28 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US9101735B2 (en) 2008-07-07 2015-08-11 Intuitive Surgical Operations, Inc. Catheter control systems
US20150238194A1 (en) * 2014-02-24 2015-08-27 Boston Scientific Scimed, Inc. Hemostasis devices and methods utilizing mechanical methods
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
US9138562B2 (en) 2007-04-18 2015-09-22 W.L. Gore & Associates, Inc. Flexible catheter system
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9149276B2 (en) 2011-03-21 2015-10-06 Abbott Cardiovascular Systems, Inc. Clip and deployment apparatus for tissue closure
US9149358B2 (en) 2008-01-24 2015-10-06 Medtronic, Inc. Delivery systems for prosthetic heart valves
US9155452B2 (en) 2007-04-27 2015-10-13 Intuitive Surgical Operations, Inc. Complex shape steerable tissue visualization and manipulation catheter
US9161836B2 (en) 2011-02-14 2015-10-20 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US20150297875A1 (en) * 2013-03-04 2015-10-22 Vascular Solutions,Inc. Vascular dilator systems, kits, and methods
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
WO2015173264A1 (en) * 2014-05-12 2015-11-19 Arrow Occlusion Systems Gmbh Wound occlusion device
US9205236B2 (en) 2011-12-22 2015-12-08 Corvia Medical, Inc. Methods, systems, and devices for resizable intra-atrial shunts
US9211181B2 (en) 2004-11-19 2015-12-15 Pulmonx Corporation Implant loading device and system
US9226738B2 (en) 2008-02-15 2016-01-05 Rex Medical, L.P. Vascular hole closure delivery device
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
US9232997B2 (en) 2006-11-07 2016-01-12 Corvia Medical, Inc. Devices and methods for retrievable intra-atrial implants
US9237886B2 (en) 2007-04-20 2016-01-19 Medtronic, Inc. Implant for treatment of a heart valve, in particular a mitral valve, material including such an implant, and material for insertion thereof
US9241707B2 (en) 2012-05-31 2016-01-26 Abbott Cardiovascular Systems, Inc. Systems, methods, and devices for closing holes in body lumens
US9248017B2 (en) 2010-05-21 2016-02-02 Sorin Group Italia S.R.L. Support device for valve prostheses and corresponding kit
US9259267B2 (en) 2005-09-06 2016-02-16 W.L. Gore & Associates, Inc. Devices and methods for treating cardiac tissue
US9259337B2 (en) 2007-06-04 2016-02-16 Sequent Medical, Inc. Methods and devices for treatment of vascular defects
US9259217B2 (en) 2012-01-03 2016-02-16 Biomet Manufacturing, Llc Suture Button
US9265514B2 (en) 2012-04-17 2016-02-23 Miteas Ltd. Manipulator for grasping tissue
US9271713B2 (en) 2006-02-03 2016-03-01 Biomet Sports Medicine, Llc Method and apparatus for tensioning a suture
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US9289289B2 (en) 2011-02-14 2016-03-22 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US9314230B2 (en) 2009-01-09 2016-04-19 Abbott Vascular Inc. Closure device with rapidly eroding anchor
US9314241B2 (en) 2011-11-10 2016-04-19 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9332992B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Method for making a laminar ventricular partitioning device
US9332993B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US9345460B2 (en) 2001-04-24 2016-05-24 Cardiovascular Technologies, Inc. Tissue closure devices, device and systems for delivery, kits and methods therefor
US9345532B2 (en) 2011-05-13 2016-05-24 Broncus Medical Inc. Methods and devices for ablation of tissue
US9351716B2 (en) 2009-06-17 2016-05-31 Coherex Medical, Inc. Medical device and delivery system for modification of left atrial appendage and methods thereof
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9364209B2 (en) 2012-12-21 2016-06-14 Abbott Cardiovascular Systems, Inc. Articulating suturing device
JP2016517776A (en) * 2013-05-07 2016-06-20 アムセル メディカル コーポレイション To occlude a blood vessel, and / or methods and apparatus for securing two objects together
US9370353B2 (en) 2010-09-01 2016-06-21 Abbott Cardiovascular Systems, Inc. Suturing devices and methods
US9370350B2 (en) 2011-11-10 2016-06-21 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9381041B2 (en) 2009-04-21 2016-07-05 Xlumena, Inc. Methods and devices for access across adjacent tissue layers
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9387634B2 (en) 2012-07-02 2016-07-12 Cavu01, Llc Patching device
US9393115B2 (en) 2008-01-24 2016-07-19 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US9414822B2 (en) 2011-05-19 2016-08-16 Abbott Cardiovascular Systems, Inc. Tissue eversion apparatus and tissue closure device and methods for use thereof
US9415225B2 (en) 2005-04-25 2016-08-16 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9414824B2 (en) 2009-01-16 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9439757B2 (en) 2014-12-09 2016-09-13 Cephea Valve Technologies, Inc. Replacement cardiac valves and methods of use and manufacture
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US9468364B2 (en) 2008-11-14 2016-10-18 Intuitive Surgical Operations, Inc. Intravascular catheter with hood and image processing systems
US9474517B2 (en) 2008-03-07 2016-10-25 W. L. Gore & Associates, Inc. Heart occlusion devices
US9474516B2 (en) 2011-11-08 2016-10-25 Boston Scientific Scimed, Inc. Handle assembly for a left atrial appendage occlusion device
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US9504568B2 (en) 2007-02-16 2016-11-29 Medtronic, Inc. Replacement prosthetic heart valves and methods of implantation
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
US9510732B2 (en) 2005-10-25 2016-12-06 Intuitive Surgical Operations, Inc. Methods and apparatus for efficient purging
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9533128B2 (en) 2003-07-18 2017-01-03 Broncus Medical Inc. Devices for maintaining patency of surgically created channels in tissue
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US9572558B2 (en) 2012-02-29 2017-02-21 Vivasure Medical Limited Devices and methods for delivering implants for percutaneous perforation closure
US9572559B2 (en) 2013-03-15 2017-02-21 Covidien Lp Port site closure
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US9585647B2 (en) 2009-08-26 2017-03-07 Abbott Laboratories Medical device for repairing a fistula
US9585651B2 (en) 2005-05-26 2017-03-07 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US9592118B2 (en) 2011-01-28 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
US20170086975A1 (en) * 2014-06-19 2017-03-30 4Tech Inc. Cardiac tissue cinching
US9610163B2 (en) 2011-01-28 2017-04-04 Middle Peak Medical, Inc. Coaptation enhancement implant, system, and method
US9610070B2 (en) 2007-06-15 2017-04-04 Vivasure Medical Limited Closure device
US9615822B2 (en) 2014-05-30 2017-04-11 Biomet Sports Medicine, Llc Insertion tools and method for soft anchor
US9629635B2 (en) 2014-04-14 2017-04-25 Sequent Medical, Inc. Devices for therapeutic vascular procedures
US9629715B2 (en) 2011-07-28 2017-04-25 V-Wave Ltd. Devices for reducing left atrial pressure having biodegradable constriction, and methods of making and using same
US9629718B2 (en) 2013-05-03 2017-04-25 Medtronic, Inc. Valve delivery tool
US9649115B2 (en) 2009-06-17 2017-05-16 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9681948B2 (en) 2006-01-23 2017-06-20 V-Wave Ltd. Heart anchor device
US9693781B2 (en) 2009-06-17 2017-07-04 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US9700291B2 (en) 2014-06-03 2017-07-11 Biomet Sports Medicine, Llc Capsule retractor
US9713696B2 (en) 2013-05-21 2017-07-25 V-Wave Ltd. Apparatus and methods for delivering devices for reducing left atrial pressure
US9731141B2 (en) 2007-06-14 2017-08-15 Cardiac Pacemakers, Inc. Multi-element acoustic recharging system
US9750595B2 (en) 2012-09-28 2017-09-05 Covidien Lp Implantable medical devices which include grip-members and methods of use thereof
US9757107B2 (en) 2009-09-04 2017-09-12 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having adjustable sizes
US9757119B2 (en) 2013-03-08 2017-09-12 Biomet Sports Medicine, Llc Visual aid for identifying suture limbs arthroscopically
US9757574B2 (en) 2015-05-11 2017-09-12 Rainbow Medical Ltd. Dual chamber transvenous pacemaker
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9775704B2 (en) 2004-04-23 2017-10-03 Medtronic3F Therapeutics, Inc. Implantable valve prosthesis
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US9814522B2 (en) 2010-04-06 2017-11-14 Intuitive Surgical Operations, Inc. Apparatus and methods for ablation efficacy
US9827404B2 (en) 2006-12-20 2017-11-28 Onset Medical Corporation Expandable trans-septal sheath
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
US9850013B2 (en) 2013-03-15 2017-12-26 Vivasure Medical Limited Loading devices and methods for percutaneous perforation closure systems
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
US9883936B2 (en) 2002-01-25 2018-02-06 Boston Scientific Scimed, Inc Atrial appendage blood filtration systems
US9901445B2 (en) 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
US9918720B2 (en) 2009-11-05 2018-03-20 Sequent Medical Inc. Multiple layer filamentary devices for treatment of vascular defects
US9918826B2 (en) 2006-09-29 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9955976B2 (en) 2013-08-16 2018-05-01 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US9955980B2 (en) 2015-02-24 2018-05-01 Biomet Sports Medicine, Llc Anatomic soft tissue repair
US10004388B2 (en) 2006-09-01 2018-06-26 Intuitive Surgical Operations, Inc. Coronary sinus cannulation
US10022114B2 (en) 2013-10-30 2018-07-17 4Tech Inc. Percutaneous tether locking
US10039543B2 (en) 2014-08-22 2018-08-07 Biomet Sports Medicine, Llc Non-sliding soft anchor
US10058323B2 (en) 2010-01-22 2018-08-28 4 Tech Inc. Tricuspid valve repair using tension
US10064696B2 (en) 2000-08-09 2018-09-04 Edwards Lifesciences Corporation Devices and methods for delivering an endocardial device
US10064628B2 (en) 2009-06-17 2018-09-04 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US10064540B2 (en) 2005-02-02 2018-09-04 Intuitive Surgical Operations, Inc. Visualization apparatus for transseptal access
US10076403B1 (en) 2009-05-04 2018-09-18 V-Wave Ltd. Shunt for redistributing atrial blood volume
US10080652B2 (en) 2015-03-13 2018-09-25 Boston Scientific Scimed, Inc. Prosthetic heart valve having an improved tubular seal
US10092288B2 (en) 2006-02-03 2018-10-09 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US10108646B2 (en) 2008-02-15 2018-10-23 Rex Medical, L.P. Vascular hole closure delivery device
US10111664B2 (en) 2014-06-23 2018-10-30 Integrated Vascular Systems, Inc. Closure system and methods of use

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3018608C1 (en) * 1980-05-13 1981-10-01 Irene Dr Warnecke balloon catheter
DE3048923C2 (en) * 1980-05-13 1983-01-20 Irene Dr. 1000 Berlin De Warnecke
FR2567405B1 (en) * 1984-07-12 1988-08-12 Lefebvre Jean Marie Filter medical use
US5003971A (en) * 1988-09-02 1991-04-02 Buckley John T Expansion system for a medical and surgical dressing
US7008439B1 (en) * 1990-09-21 2006-03-07 Datascope Investments Corp. Device and method for sealing puncture wounds
US5391183A (en) * 1990-09-21 1995-02-21 Datascope Investment Corp Device and method sealing puncture wounds
US6325789B1 (en) 1990-12-27 2001-12-04 Datascope Investment Corporation Device and method for sealing puncture wounds
US5403278A (en) * 1992-04-15 1995-04-04 Datascope Investment Corp. Device and method for treating hematomas and false aneurysms
DE4222291C1 (en) * 1992-07-07 1994-01-20 Krmek Mirko Prosthesis for closing atrial or ventricular-septal defect - comprises two equally shaped units of elastic sprung material with six radially running arms spaced apart by equal edges
GB2269321B (en) * 1992-08-05 1996-06-26 Nat Heart & Lung Inst Implantable occluder devices for medical use
US5681349A (en) * 1992-08-13 1997-10-28 Brigham & Women's Hospital Expanding polygonal surgical compressor
WO1994004080A1 (en) * 1992-08-13 1994-03-03 Brigham & Women's Hospital Expanding polygonal surgical compressor
US5891162A (en) * 1992-08-13 1999-04-06 Brigham & Women's Hospital Expanding polygonal surgical compressor
US5383896A (en) * 1993-05-25 1995-01-24 Gershony; Gary Vascular sealing device
US6017359A (en) * 1993-05-25 2000-01-25 Vascular Solutions, Inc. Vascular sealing apparatus
US5728122A (en) * 1994-01-18 1998-03-17 Datascope Investment Corp. Guide wire with releaseable barb anchor
US5868778A (en) 1995-10-27 1999-02-09 Vascular Solutions, Inc. Vascular sealing apparatus and method
DE19604817C2 (en) 1996-02-09 2003-06-12 Pfm Prod Fuer Die Med Ag Device for closure of defect openings in the human or animal body
US6488706B1 (en) 1996-05-08 2002-12-03 Carag Ag Device for plugging an opening such as in a wall of a hollow or tubular organ
US6949116B2 (en) 1996-05-08 2005-09-27 Carag Ag Device for plugging an opening such as in a wall of a hollow or tubular organ including biodegradable elements
US7695492B1 (en) 1999-09-23 2010-04-13 Boston Scientific Scimed, Inc. Enhanced bleed back system
US6200328B1 (en) 1998-05-01 2001-03-13 Sub Q, Incorporated Device and method for facilitating hemostasis of a biopsy tract
US6162192A (en) * 1998-05-01 2000-12-19 Sub Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
EP1156741B1 (en) 1999-02-10 2010-12-22 Sub-Q, Inc. Device for facilitating hemostasis of a biopsy tract
US6183497B1 (en) 1998-05-01 2001-02-06 Sub-Q, Inc. Absorbable sponge with contrasting agent
US6315753B1 (en) 1998-05-01 2001-11-13 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6610026B2 (en) 1998-05-01 2003-08-26 Sub-Q, Inc. Method of hydrating a sponge material for delivery to a body
US20010045575A1 (en) 1998-05-01 2001-11-29 Mark Ashby Device and method for facilitating hemostasis of a biopsy tract
US6071301A (en) 1998-05-01 2000-06-06 Sub Q., Inc. Device and method for facilitating hemostasis of a biopsy tract
US8317821B1 (en) 2002-11-04 2012-11-27 Boston Scientific Scimed, Inc. Release mechanism
DE10000137A1 (en) 2000-01-04 2001-07-12 Pfm Prod Fuer Die Med Ag Implantate for closing defect apertures in human or animal bodies, bearing structure of which can be reversed from secondary to primary form by elastic force
US6540735B1 (en) 2000-05-12 2003-04-01 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US8187625B2 (en) 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
US7955353B1 (en) 2002-11-04 2011-06-07 Sub-Q, Inc. Dissolvable closure device
US7875043B1 (en) 2003-12-09 2011-01-25 Sub-Q, Inc. Cinching loop
US8489649B2 (en) 2010-12-13 2013-07-16 Oracle International Corporation Extensible RDF databases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2493326A (en) * 1949-03-01 1950-01-03 John H Trinder Tampon for control of intractable nasal hemorrhages
US3334629A (en) * 1964-11-09 1967-08-08 Bertram D Cohn Occlusive device for inferior vena cava
US3540431A (en) * 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US3574865A (en) * 1968-08-08 1971-04-13 Michigan Instr Inc Prosthetic sutureless heart valve
US3675639A (en) * 1970-05-11 1972-07-11 Hugo S Cimber Device for and method of temporary sterilizing a female

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2493326A (en) * 1949-03-01 1950-01-03 John H Trinder Tampon for control of intractable nasal hemorrhages
US3334629A (en) * 1964-11-09 1967-08-08 Bertram D Cohn Occlusive device for inferior vena cava
US3540431A (en) * 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US3574865A (en) * 1968-08-08 1971-04-13 Michigan Instr Inc Prosthetic sutureless heart valve
US3675639A (en) * 1970-05-11 1972-07-11 Hugo S Cimber Device for and method of temporary sterilizing a female

Cited By (1935)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2328483A1 (en) * 1975-10-20 1977-05-20 American Hospital Supply Corp Mechanism of deployment of a device umbrella-shaped closure of an intravascular shunt
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4031569A (en) * 1976-03-15 1977-06-28 Jacob H John Nasal septum plug
US4056854A (en) * 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4092742A (en) * 1976-10-18 1978-06-06 Sinai Hospital Of Detroit Dynamic prosthetic myocardium
US6610085B1 (en) 1983-12-09 2003-08-26 Endovascular Technologies, Inc. Intraluminal repair device and method
US6030413A (en) * 1983-12-09 2000-02-29 Endovascular Technologies, Inc. Artificial graft and implantation method
US5275622A (en) * 1983-12-09 1994-01-04 Harrison Medical Technologies, Inc. Endovascular grafting apparatus, system and method and devices for use therewith
US5662700A (en) * 1983-12-09 1997-09-02 Endovascular Technologies, Inc. Artificial graft and implantation method
US4787899A (en) * 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US5397345A (en) * 1983-12-09 1995-03-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US6017364A (en) * 1983-12-09 2000-01-25 Endovascular Technologies, Inc. Intraluminal repair device and catheter
US4562596A (en) * 1984-04-25 1986-01-07 Elliot Kornberg Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair
US4617932A (en) * 1984-04-25 1986-10-21 Elliot Kornberg Device and method for performing an intraluminal abdominal aortic aneurysm repair
FR2573647A1 (en) * 1984-11-28 1986-05-30 Catier Philippe Device for repairing a meniscus by endoscopy alone
US4710192A (en) * 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4779616A (en) * 1986-02-04 1988-10-25 Johnson Lanny L Surgical suture-snagging method
US4793348A (en) * 1986-11-15 1988-12-27 Palmaz Julio C Balloon expandable vena cava filter to prevent migration of lower extremity venous clots into the pulmonary circulation
US4744364A (en) * 1987-02-17 1988-05-17 Intravascular Surgical Instruments, Inc. Device for sealing percutaneous puncture in a vessel
US4890612A (en) * 1987-02-17 1990-01-02 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
USRE34866E (en) * 1987-02-17 1995-02-21 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
US4852568A (en) * 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
US20040127969A1 (en) * 1987-04-06 2004-07-01 Lazarus Harrison M. Artificial graft and implantation method
US6416535B1 (en) 1987-04-06 2002-07-09 Endovascular Technologies, Inc. Artificial graft and implantation method
US4773420A (en) * 1987-06-22 1988-09-27 U.S. Surgical Corporation Purse string applicator
US4836204A (en) * 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
US6923828B1 (en) 1987-10-19 2005-08-02 Medtronic, Inc. Intravascular stent
US6656219B1 (en) 1987-10-19 2003-12-02 Dominik M. Wiktor Intravascular stent
US6860901B1 (en) 1988-03-09 2005-03-01 Endovascular Technologies, Inc. Intraluminal grafting system
US7166125B1 (en) 1988-03-09 2007-01-23 Endovascular Technologies, Inc. Intraluminal grafting system
US6702844B1 (en) 1988-03-09 2004-03-09 Endovascular Technologies, Inc. Artificial graft and implantation method
EP0688544A2 (en) 1988-03-09 1995-12-27 Endovascular Technologies, Inc. Artificial graft and implantation method
WO1989011301A1 (en) * 1988-05-16 1989-11-30 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
US5053046A (en) * 1988-08-22 1991-10-01 Woodrow W. Janese Dural sealing needle and method of use
US4917089A (en) * 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
EP0362113A1 (en) * 1988-08-29 1990-04-04 Eleftherios B. Sideris Buttoned device for the transvenous occlusion of intracardiac defects
US7169168B2 (en) 1989-05-29 2007-01-30 Kensey Nash Corporation Sealing device
US5593422A (en) * 1989-05-29 1997-01-14 Muijs Van De Moer; Wouter M. Occlusion assembly for sealing openings in blood vessels and a method for sealing openings in blood vessels
US20040098044A1 (en) * 1989-05-29 2004-05-20 Van De Moer Wouter Matthijs Muijs Sealing device
US5620461A (en) * 1989-05-29 1997-04-15 Muijs Van De Moer; Wouter M. Sealing device
US6663661B2 (en) 1989-08-24 2003-12-16 Medtronic Ave, Inc. Endovascular support device and method
US6827733B2 (en) 1989-08-24 2004-12-07 Medtronic Ave, Inc. Endovascular support device and method
US20040064180A1 (en) * 1989-08-24 2004-04-01 Boneau Michael D. Endovascular support device and method
US20050119726A1 (en) * 1989-08-24 2005-06-02 Medtronic Vascular, Inc. Endovascular support device and method
WO1993007813A1 (en) * 1989-12-04 1993-04-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5192302A (en) * 1989-12-04 1993-03-09 Kensey Nash Corporation Plug devices for sealing punctures and methods of use
US5171259A (en) * 1990-04-02 1992-12-15 Kanji Inoue Device for nonoperatively occluding a defect
WO1991016858A1 (en) 1990-05-07 1991-11-14 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
US5021059A (en) * 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
US5478352A (en) * 1990-10-01 1995-12-26 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5601602A (en) * 1990-10-01 1997-02-11 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5192300A (en) * 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5591205A (en) * 1990-10-01 1997-01-07 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5141515A (en) * 1990-10-11 1992-08-25 Eberbach Mark A Apparatus and methods for repairing hernias
US5366460A (en) * 1990-10-11 1994-11-22 Cook Incorporated Apparatus and method for laparoscope hernia repair
US5116357A (en) * 1990-10-11 1992-05-26 Eberbach Mark A Hernia plug and introducer apparatus
US5122155A (en) * 1990-10-11 1992-06-16 Eberbach Mark A Hernia repair apparatus and method of use
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
WO1992019162A3 (en) * 1991-04-24 1992-12-10 Arnold S Seid Surgical implantation device and related method of use
US5254133A (en) * 1991-04-24 1993-10-19 Seid Arnold S Surgical implantation device and related method of use
WO1992019162A2 (en) * 1991-04-24 1992-11-12 Seid Arnold S Surgical implantation device and related method of use
US6029671A (en) * 1991-07-16 2000-02-29 Heartport, Inc. System and methods for performing endovascular procedures
US5383477A (en) * 1991-08-02 1995-01-24 Dematteis; Ralph A. Method and apparatus for laparoscopic repair of hernias
WO1993003685A1 (en) * 1991-08-19 1993-03-04 Mark Allen Eberbach Surgical apparatus and method
EP0534696A1 (en) * 1991-09-23 1993-03-31 Jay Erlebacher A sealing device and an insertion tool therefor
US20070135842A1 (en) * 1991-10-22 2007-06-14 Kensey Nash Corporation Sealing device
US5451235A (en) * 1991-11-05 1995-09-19 C.R. Bard, Inc. Occluder and method for repair of cardiac and vascular defects
US5425744A (en) * 1991-11-05 1995-06-20 C. R. Bard, Inc. Occluder for repair of cardiac and vascular defects
US6045569A (en) * 1991-11-08 2000-04-04 Kensey Nash Corporation Hemostatic puncture closure system including closure locking means and methods of use
US5861004A (en) * 1991-11-08 1999-01-19 Kensey Nash Corporation Hemostatic puncture closure system including closure locking means and method of use
US5411520A (en) * 1991-11-08 1995-05-02 Kensey Nash Corporation Hemostatic vessel puncture closure system utilizing a plug located within the puncture tract spaced from the vessel, and method of use
US5222974A (en) * 1991-11-08 1993-06-29 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US6007563A (en) * 1991-11-08 1999-12-28 Kensey Nash Corporation Method of deploying percutaneous puncture closure
US6090130A (en) * 1991-11-08 2000-07-18 Kensey Nash Corporation Hemostatic puncture closure system including blood vessel locator and method of use
US5676689A (en) * 1991-11-08 1997-10-14 Kensey Nash Corporation Hemostatic puncture closure system including vessel location device and method of use
EP0544485A1 (en) * 1991-11-25 1993-06-02 Cook Incorporated Tissue aperture repair device
US5258000A (en) * 1991-11-25 1993-11-02 Cook Incorporated Tissue aperture repair device
WO1993010714A1 (en) * 1991-11-29 1993-06-10 William Cook Europe A/S Closure prosthesis for transcatheter placement
US6077291A (en) * 1992-01-21 2000-06-20 Regents Of The University Of Minnesota Septal defect closure device
US6077281A (en) * 1992-01-21 2000-06-20 Regents Of The University Of Minnesota Septal defect closure device
WO1993013712A1 (en) * 1992-01-21 1993-07-22 Regents Of The University Of Minnesota Septal defect closure device
EP0876793A2 (en) 1992-01-21 1998-11-11 Regents Of The University Of Minnesota Septal Defect Closure Device
US5578045A (en) * 1992-01-21 1996-11-26 Regents Of The University Of Minnesota Septal defect closure device
EP0876793A3 (en) * 1992-01-21 1998-12-02 Regents Of The University Of Minnesota Septal Defect Closure Device
US5334217A (en) * 1992-01-21 1994-08-02 Regents Of The University Of Minnesota Septal defect closure device
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
US5649950A (en) * 1992-01-22 1997-07-22 C. R. Bard System for the percutaneous transluminal front-end loading delivery and retrieval of a prosthetic occluder
US5626599A (en) * 1992-01-22 1997-05-06 C. R. Bard Method for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
EP0556564B1 (en) * 1992-01-22 1997-08-06 C.R. Bard, Inc. System for the percutaneous transluminal delivery and retrieval of a prosthetic occluder
EP0556564A2 (en) * 1992-01-22 1993-08-25 C.R. Bard, Inc. System and method for the percutaneous transluminal delivery and retrieval of a prosthetic occluder
EP0556564A3 (en) * 1992-01-22 1993-10-20 Bard Inc C R System and method for the percutaneous transluminal delivery and retrieval of a prosthetic occluder
US5405360A (en) * 1992-02-24 1995-04-11 United States Surgical Corporation Resilient arm mesh deployer
US5507744A (en) * 1992-04-23 1996-04-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US5810810A (en) * 1992-04-23 1998-09-22 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US6063085A (en) * 1992-04-23 2000-05-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
USRE40863E1 (en) * 1992-04-23 2009-07-21 Boston Scientific Scimed, Inc. Apparatus and method for sealing vascular punctures
US5413571A (en) * 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
US5630833A (en) * 1992-07-16 1997-05-20 Sherwood Medical Company Device for sealing hemostatic incisions
US5540715A (en) * 1992-07-16 1996-07-30 Sherwood Medical Company Device for sealing hemostatic incisions
US5342393A (en) * 1992-08-27 1994-08-30 Duke University Method and device for vascular repair
WO1994008513A1 (en) * 1992-10-13 1994-04-28 Taymor Luria Howard Percutaneous vascular sealing apparatus and method
US6398782B1 (en) 1992-10-13 2002-06-04 Edwards Lifesciences Corporation Bipolar vascular sealing apparatus and methods
US5415657A (en) * 1992-10-13 1995-05-16 Taymor-Luria; Howard Percutaneous vascular sealing method
US5383897A (en) * 1992-10-19 1995-01-24 Shadyside Hospital Method and apparatus for closing blood vessel punctures
US5643317A (en) * 1992-11-25 1997-07-01 William Cook Europe S.A. Closure prosthesis for transcatheter placement
US5947997A (en) * 1992-11-25 1999-09-07 William Cook Europe A/S Closure prothesis for transcatheter placement
US20040186487A1 (en) * 1992-12-10 2004-09-23 Klein Enrique J. Device and method for suturing tissue
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
WO1994017738A2 (en) * 1993-02-03 1994-08-18 Kensey Nash Corporation Hemostatic vessel puncture closure system and method of use
WO1994017738A3 (en) * 1993-02-03 1994-10-13 Kensey Nash Corp Hemostatic vessel puncture closure system and method of use
US6679268B2 (en) 1993-02-22 2004-01-20 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US20020100485A1 (en) * 1993-02-22 2002-08-01 Stevens John H. Method and apparatus for thoracoscopic intracardiac procedures
US7100614B2 (en) 1993-02-22 2006-09-05 Heartport, Inc. Method of Forming a Lesion in Heart Tissue
US6401720B1 (en) 1993-02-22 2002-06-11 John H. Stevens Method and apparatus for thoracoscopic intracardiac procedures
US5829447A (en) * 1993-02-22 1998-11-03 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US6651672B2 (en) 1993-02-22 2003-11-25 Heartport, Inc. Devices for less-invasive intracardiac interventions
US6346074B1 (en) 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US20040117032A1 (en) * 1993-02-22 2004-06-17 Roth Alex T. Devices for less-invasive intracardiac interventions
US5855614A (en) * 1993-02-22 1999-01-05 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US6955175B2 (en) 1993-02-22 2005-10-18 Stevens John H Method and apparatus for thoracoscopic intracardiac procedures
US5823956A (en) * 1993-02-22 1998-10-20 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US5797960A (en) * 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
WO1995002371A3 (en) * 1993-07-15 1995-03-09 Aws Shakir Mustafa Salim Rectal and rectosigmoid cancer tunnelling umbrella
WO1995002371A2 (en) * 1993-07-15 1995-01-26 Aws Shakir Mustafa Salim Rectal and rectosigmoid cancer tunnelling umbrella
US5431639A (en) * 1993-08-12 1995-07-11 Boston Scientific Corporation Treating wounds caused by medical procedures
US5507811A (en) * 1993-11-26 1996-04-16 Nissho Corporation Prosthetic device for atrial septal defect repair
US6344053B1 (en) 1993-12-22 2002-02-05 Medtronic Ave, Inc. Endovascular support device and method
FR2714284A1 (en) * 1993-12-23 1995-06-30 Petitier Hubert Prosthesis for repairing heart wall defects
EP0793457B1 (en) * 1994-04-06 2001-10-31 WILLIAM COOK EUROPE ApS A medical article for implantation into the vascular system of a patient
US5683411A (en) * 1994-04-06 1997-11-04 William Cook Europe A/S Medical article for implantation into the vascular system of a patient
US6368339B1 (en) 1994-07-08 2002-04-09 Aga Medical Corporation Method of forming medical devices: intra-vascular occlusion devices
US5725552A (en) * 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5846261A (en) * 1994-07-08 1998-12-08 Aga Medical Corp. Percutaneous catheter directed occlusion devices
US5433727A (en) * 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
EP0698373A3 (en) * 1994-08-24 1996-06-12 Bernhard Schneidt Occlusion device for closing an opening in a vessel
EP0698373A2 (en) * 1994-08-24 1996-02-28 Bernhard Schneidt Occlusion device for closing an opening in a vessel
EP0706778A1 (en) * 1994-10-13 1996-04-17 Ethicon, Inc. Applicator for introducing flexible areal implants through an operative channel
US6171329B1 (en) 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US5634936A (en) * 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
US6270515B1 (en) 1995-02-06 2001-08-07 Scimed Life Systems, Inc. Device for closing a septal defect
US5649959A (en) * 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
WO1996032882A1 (en) 1995-04-20 1996-10-24 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
EP1980200A2 (en) 1995-04-20 2008-10-15 Heartport, Inc. Method and apparatus for thoracoscopic intradcardiac procedures
US6814748B1 (en) 1995-06-07 2004-11-09 Endovascular Technologies, Inc. Intraluminal grafting system
US5749918A (en) * 1995-07-20 1998-05-12 Endotex Interventional Systems, Inc. Intraluminal graft and method for inserting the same
US5713907A (en) * 1995-07-20 1998-02-03 Endotex Interventional Systems, Inc. Apparatus and method for dilating a lumen and for inserting an intraluminal graft
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US6117159A (en) * 1996-03-22 2000-09-12 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5853422A (en) * 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US6312446B1 (en) 1996-03-22 2001-11-06 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US6024756A (en) * 1996-03-22 2000-02-15 Scimed Life Systems, Inc. Method of reversibly closing a septal defect
EP1582151A3 (en) * 1996-05-08 2006-04-19 Carag AG A device for plugging an opening in a wall of a hollow or tubular organ
EP1582151A2 (en) * 1996-05-08 2005-10-05 Carag AG A device for plugging an opening in a wall of a hollow or tubular organ
EP1994887A1 (en) * 1996-05-08 2008-11-26 Carag AG A device for plugging an opening such as in a wall of a hollow or tubular organ
WO1997042878A1 (en) 1996-05-14 1997-11-20 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
EP0920842A1 (en) * 1996-07-09 1999-06-09 Vladimir Leonidovich Karpenko Micro-surgery fixation device, variants and manipulation push-bar for mounting the same
EP0920842A4 (en) * 1996-07-09 1999-08-25 Boris Petrovich Kruchinin Micro-surgery fixation device, variants and manipulation push-bar for mounting the same
US5741297A (en) * 1996-08-28 1998-04-21 Simon; Morris Daisy occluder and method for septal defect repair
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US6623508B2 (en) 1996-12-20 2003-09-23 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US6056760A (en) * 1997-01-30 2000-05-02 Nissho Corporation Device for intracardiac suture
EP0856285A1 (en) * 1997-01-30 1998-08-05 Nissho Corporation Device for intracardiac suture
US7670373B1 (en) 1997-04-30 2010-03-02 Pulmonx Corporation Occlusion device
US20070005083A1 (en) * 1997-04-30 2007-01-04 Sabaratham Sabanathan Occlusion device
US8136520B2 (en) 1997-04-30 2012-03-20 Pulmonx Corporation Occlusion device
US9795387B2 (en) 1997-05-19 2017-10-24 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US6015427A (en) * 1997-07-07 2000-01-18 Eclipse Surgical Technologies, Inc. Heart stabilizer with controllable stay suture and cutting element
US20150164512A1 (en) * 1997-07-10 2015-06-18 Stryker Corporation Methods and devices for the treatment of aneurysms
US9307998B2 (en) * 1997-07-10 2016-04-12 Stryker Corporation Methods and devices for the treatment of aneurysms
WO1999007289A1 (en) 1997-08-08 1999-02-18 Cardia, Inc. Occlusion device for the closure of a physical anomaly
US6241768B1 (en) 1997-08-27 2001-06-05 Ethicon, Inc. Prosthetic device for the repair of a hernia
US6113641A (en) * 1997-08-27 2000-09-05 Ethicon, Inc. Prosthesis for the obturation of a hernial canal
JPH11146888A (en) * 1997-08-27 1999-06-02 Ethicon Inc Prosthesis for hernia treatment
US6180848B1 (en) 1997-08-27 2001-01-30 Ethicon, Inc. Prosthesis obturating device for the obturation of a hernial canal
WO1999012478A1 (en) 1997-09-08 1999-03-18 Aga Medical Corporation Percutaneous catheter directed occlusion devices
US9510837B2 (en) 1997-09-12 2016-12-06 Evalve, Inc. Surgical device for connecting soft tissue
US7981123B2 (en) 1997-09-12 2011-07-19 Evalve, Inc. Surgical device for connecting soft tissue
US8740918B2 (en) 1997-09-12 2014-06-03 Evalve, Inc. Surgical device for connecting soft tissue
US20030212452A1 (en) * 1997-09-16 2003-11-13 Gholam-Reza Zadno-Azizi Body fluid flow control device
US20030199972A1 (en) * 1997-09-16 2003-10-23 Gholam-Reza Zadno-Azizi Body fluid flow control device
US7276077B2 (en) 1997-09-16 2007-10-02 Emphasys Medical, Inc. Body fluid flow control device
US20020095209A1 (en) * 1997-09-16 2002-07-18 Gholam-Reza Zadno-Azizi Body fluid flow control device
US6632243B1 (en) 1997-09-16 2003-10-14 Emphasys Medical Inc. Body fluid flow control device
US7033387B2 (en) 1997-09-16 2006-04-25 Emphasys Medical, Inc. Body fluid flow control device
US5895404A (en) * 1997-09-29 1999-04-20 Ruiz; Carlos E. Apparatus and methods for percutaneously forming a passageway between adjacent vessels or portions of a vessel
US5976174A (en) * 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US7575586B2 (en) 1998-01-30 2009-08-18 St. Jude Medical Atg, Inc. Medical graft connector or plug structures, and methods of making and installing same
EP1685808A3 (en) * 1998-01-30 2008-02-20 St.Jude Medical ATG, Inc. Medical graft connector or plug structures, and methods of making and installing same
US20040078053A1 (en) * 1998-01-30 2004-04-22 St. Jude Medical Atg, Inc. Medical graft connector or plug structures, and methods of making and installing same
EP2263569A1 (en) 1998-02-06 2010-12-22 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
WO1999039646A1 (en) 1998-02-06 1999-08-12 Aga Medical Corp. Percutaneous catheter directed constricting occlusion device
US5944738A (en) * 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
EP1844717A2 (en) 1998-02-06 2007-10-17 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
WO1999040849A1 (en) 1998-02-10 1999-08-19 Jeffrey Jump Surgical device for occlusion of defects
US20100081869A1 (en) * 1998-05-01 2010-04-01 Buckberg Gerald D Ventricular Restoration Patch
US20030191538A1 (en) * 1998-05-01 2003-10-09 Buckberg Gerald D. Method of using ventricular restoration patch
US7056280B2 (en) 1998-05-01 2006-06-06 Correstore, Inc. Anterior segment ventricular restoration apparatus and method
US6544167B2 (en) 1998-05-01 2003-04-08 Correstore, Inc. Ventricular restoration patch
US20050119520A1 (en) * 1998-05-01 2005-06-02 Buckberg Gerald D. Method of using ventricular restoration patch
US20060258900A1 (en) * 1998-05-01 2006-11-16 Buckberg Gerald D Anterior Segment Ventricular Restoration Apparatus and Method
US6450171B1 (en) 1998-05-01 2002-09-17 Correstore, Inc. Anterior and inferior segment ventricular restoration apparatus and method
US6837247B2 (en) 1998-05-01 2005-01-04 Correstore, Inc. Method of using ventricular restoration patch
US20020198603A1 (en) * 1998-05-01 2002-12-26 Correstore, Inc. Anterior segment ventricular restoration apparatus and method
US20040181126A1 (en) * 1998-05-01 2004-09-16 Buckberg Gerald D. Anterior and inferior segment ventricular restoration apparatus and method
US7914438B2 (en) 1998-05-01 2011-03-29 Correstore Llc Ventricular restoration patch
US6221104B1 (en) 1998-05-01 2001-04-24 Cor Restore, Inc. Anterior and interior segment cardiac restoration apparatus and method
US7758494B2 (en) 1998-05-01 2010-07-20 Correstore, Inc. Anterior segment ventricular restoration apparatus and method
US6024096A (en) * 1998-05-01 2000-02-15 Correstore Inc Anterior segment ventricular restoration apparatus and method
US7594886B2 (en) 1998-05-01 2009-09-29 Correstore Llc Method of using ventricular restoration patch
US6439237B1 (en) 1998-05-01 2002-08-27 Correstore, Inc. Anterior segment coronary restoration apparatus and method
US7275546B2 (en) 1998-05-01 2007-10-02 Buckberg Gerald D Anterior and inferior segment ventricular restoration apparatus and method
US6168615B1 (en) 1998-05-04 2001-01-02 Micrus Corporation Method and apparatus for occlusion and reinforcement of aneurysms
US9282969B2 (en) 1998-05-26 2016-03-15 Boston Scientific Scimed, Inc. Methods for treating a gastrointestinal tract
EP1079741A1 (en) * 1998-05-26 2001-03-07 Boston Scientific Limited Implantable tissue fastener and system for treating gastroesophageal reflux disease
US8157836B2 (en) 1998-05-26 2012-04-17 Boston Scientific Scimed, Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
EP1079741A4 (en) * 1998-05-26 2004-12-08 Boston Scient Ltd Implantable tissue fastener and system for treating gastroesophageal reflux disease
US8663274B2 (en) 1998-05-26 2014-03-04 Boston Scientific Scimed, Inc. Implantable tissue fastener and system for treating a gastrointestinal tract
US20040097986A1 (en) * 1998-05-26 2004-05-20 Scimed Life Systems Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
US7763040B2 (en) 1998-06-03 2010-07-27 Medtronic, Inc. Tissue connector apparatus and methods
US7963973B2 (en) 1998-06-03 2011-06-21 Medtronic, Inc. Multiple loop tissue connector apparatus and methods
US7547313B2 (en) 1998-06-03 2009-06-16 Medtronic, Inc. Tissue connector apparatus and methods
US7569062B1 (en) * 1998-07-15 2009-08-04 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US20040167539A1 (en) * 1998-07-15 2004-08-26 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US6695866B1 (en) * 1998-07-15 2004-02-24 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US6440120B1 (en) * 1998-09-02 2002-08-27 Embol-X, Inc. Bendable shape-retaining cannula
US20030199923A1 (en) * 1998-11-06 2003-10-23 Ev3 Sunnyvale, Inc., A California Corporation Adjustable left atrial appendage implant deployment system
US7128073B1 (en) 1998-11-06 2006-10-31 Ev3 Endovascular, Inc. Method and device for left atrial appendage occlusion
US8080032B2 (en) 1998-11-06 2011-12-20 Atritech, Inc. Method and device for left atrial appendage occlusion
US20050004652A1 (en) * 1998-11-06 2005-01-06 Van Der Burg Eric J. Method for left atrial appendage occlusion
US20050203568A1 (en) * 1998-11-06 2005-09-15 Burg Erik J.V. Filter mesh for preventing passage of embolic material form an atrial appendage
US20040044361A1 (en) * 1998-11-06 2004-03-04 Frazier Andrew G.C. Detachable atrial appendage occlusion balloon
US7722641B2 (en) 1998-11-06 2010-05-25 Atritech, Inc. Filter mesh for preventing passage of embolic material form an atrial appendage
US7152605B2 (en) * 1998-11-06 2006-12-26 Ev3 Endovascular, Inc. Adjustable left atrial appendage implant deployment system
US8834519B2 (en) 1998-11-06 2014-09-16 Artritech, Inc. Method and device for left atrial appendage occlusion
US6152144A (en) * 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US20040098031A1 (en) * 1998-11-06 2004-05-20 Van Der Burg Erik J. Method and device for left atrial appendage occlusion
US7713282B2 (en) 1998-11-06 2010-05-11 Atritech, Inc. Detachable atrial appendage occlusion balloon
US9168043B2 (en) 1998-11-06 2015-10-27 Atritech, Inc. Method for left atrial appendage occlusion
US8523897B2 (en) 1998-11-06 2013-09-03 Atritech, Inc. Device for left atrial appendage occlusion
US8535343B2 (en) 1998-11-06 2013-09-17 Atritech, Inc. Method for left atrial appendage occlusion
US20110218566A1 (en) * 1998-11-06 2011-09-08 Atritech, Inc. Method for left atrial appendage occlusion
US7892255B2 (en) 1999-03-01 2011-02-22 Medtronic, Inc. Tissue connector apparatus and methods
US8353921B2 (en) 1999-03-01 2013-01-15 Medtronic, Inc Tissue connector apparatus and methods
US20030078603A1 (en) * 1999-03-01 2003-04-24 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US7722643B2 (en) 1999-03-01 2010-05-25 Medtronic, Inc. Tissue connector apparatus and methods
US8118822B2 (en) 1999-03-01 2012-02-21 Medtronic, Inc. Bridge clip tissue connector apparatus and methods
US7842047B2 (en) 1999-03-04 2010-11-30 Abbott Laboratories Articulating suturing device and method
US8048092B2 (en) 1999-03-04 2011-11-01 Abbott Laboratories Articulating suturing device and method
US7837696B2 (en) 1999-03-04 2010-11-23 Abbott Laboratories Articulating suturing device and method
US20040092964A1 (en) * 1999-03-04 2004-05-13 Modesitt D. Bruce Articulating suturing device and method
US8172860B2 (en) 1999-03-04 2012-05-08 Abbott Laboratories Articulating suturing device and method
US8057491B2 (en) 1999-03-04 2011-11-15 Abbott Laboratories Articulating suturing device and method
US9282960B2 (en) 1999-03-04 2016-03-15 Abbott Laboratories Articulating suturing device and method
US8323298B2 (en) 1999-03-04 2012-12-04 Abbott Laboratories Articulating suturing device and method
US7846170B2 (en) 1999-03-04 2010-12-07 Abbott Laboratories Articulating suturing device and method
US8038688B2 (en) 1999-03-04 2011-10-18 Abbott Laboratories Articulating suturing device and method
US7850701B2 (en) 1999-03-04 2010-12-14 Abbott Laboratories Articulating suturing device and method
US9993237B2 (en) 1999-03-04 2018-06-12 Abbott Laboratories Articulating suturing device and method
US20050143761A1 (en) * 1999-03-04 2005-06-30 Modesitt D. B. Articulating suturing device and method
US9301747B2 (en) 1999-03-04 2016-04-05 Abbott Laboratories Articulating suturing device and method
US8663248B2 (en) 1999-03-04 2014-03-04 Abbott Laboratories Articulating suturing device and method
US8211131B2 (en) 1999-04-05 2012-07-03 Medtronic, Inc. Apparatus and methods for anastomosis
US7938840B2 (en) 1999-04-05 2011-05-10 Medtronic, Inc. Apparatus and methods for anastomosis
US8409273B2 (en) 1999-04-09 2013-04-02 Abbott Vascular Inc Multi-catheter steerable guiding system and methods of use
US8734505B2 (en) 1999-04-09 2014-05-27 Evalve, Inc. Methods and apparatus for cardiac valve repair
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US7704269B2 (en) 1999-04-09 2010-04-27 Evalve, Inc. Methods and apparatus for cardiac valve repair
US8029518B2 (en) 1999-04-09 2011-10-04 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US20090163934A1 (en) * 1999-04-09 2009-06-25 Evalve, Inc. Detachment mechanism for implantable fixation devices
US8500761B2 (en) 1999-04-09 2013-08-06 Abbott Vascular Fixation devices, systems and methods for engaging tissue
US7563273B2 (en) * 1999-04-09 2009-07-21 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US8343174B2 (en) 1999-04-09 2013-01-01 Evalve, Inc. Locking mechanisms for fixation devices and methods of engaging tissue
US8123703B2 (en) 1999-04-09 2012-02-28 Evalve, Inc. Steerable access sheath and methods of use
US8740920B2 (en) 1999-04-09 2014-06-03 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US9044246B2 (en) 1999-04-09 2015-06-02 Abbott Vascular Inc. Methods and devices for capturing and fixing leaflets in valve repair
US7736388B2 (en) 1999-04-09 2010-06-15 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US8187299B2 (en) 1999-04-09 2012-05-29 Evalve, Inc. Methods and apparatus for cardiac valve repair
US8057493B2 (en) 1999-04-09 2011-11-15 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US20040225300A1 (en) * 1999-04-09 2004-11-11 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US7998151B2 (en) 1999-04-09 2011-08-16 Evalve, Inc. Leaflet suturing
US7753923B2 (en) 1999-04-09 2010-07-13 Evalve, Inc. Leaflet suturing
US9510829B2 (en) 1999-04-09 2016-12-06 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US6328757B1 (en) 1999-04-23 2001-12-11 Robert G. Matheny Device and method for performing surgery without impeding organ function
US6309350B1 (en) 1999-05-03 2001-10-30 Tricardia, L.L.C. Pressure/temperature/monitor device for heart implantation
US6645143B2 (en) 1999-05-03 2003-11-11 Tricardia, L.L.C. Pressure/temperature/flow monitor device for vascular implantation
US6656206B2 (en) * 1999-05-13 2003-12-02 Cardia, Inc. Occlusion device with non-thrombogenic properties
US6379368B1 (en) * 1999-05-13 2002-04-30 Cardia, Inc. Occlusion device with non-thrombogenic properties
US7744613B2 (en) 1999-06-25 2010-06-29 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7955340B2 (en) 1999-06-25 2011-06-07 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7704264B2 (en) 1999-06-25 2010-04-27 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US8343175B2 (en) 1999-06-25 2013-01-01 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US8574243B2 (en) 1999-06-25 2013-11-05 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US20050245945A1 (en) * 1999-06-25 2005-11-03 Usgi Medical Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US20050075653A1 (en) * 1999-06-25 2005-04-07 Usgi Medical Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US20100211086A1 (en) * 1999-06-25 2010-08-19 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US20030070676A1 (en) * 1999-08-05 2003-04-17 Cooper Joel D. Conduits having distal cage structure for maintaining collateral channels in tissue and related methods
US20030050685A1 (en) * 1999-08-09 2003-03-13 Nikolic Serjan D. Method for improving cardiac function
US9694121B2 (en) * 1999-08-09 2017-07-04 Cardiokinetix, Inc. Systems and methods for improving cardiac function
US20090254195A1 (en) * 1999-08-09 2009-10-08 Alexander Khairkhahan System for improving cardiac function by sealing a partitioning membrane within a ventricle
WO2004012629A1 (en) * 1999-08-09 2004-02-12 Cardiokinetix, Inc. A device for improving cardiac function
US7887477B2 (en) 1999-08-09 2011-02-15 Cardiokinetix, Inc. Method of improving cardiac function using a porous membrane
US7303526B2 (en) 1999-08-09 2007-12-04 Cardiokinetix, Inc. Device for improving cardiac function
US8657873B2 (en) 1999-08-09 2014-02-25 Cardiokinetix, Inc. System for improving cardiac function
US8246671B2 (en) 1999-08-09 2012-08-21 Cardiokinetix, Inc. Retrievable cardiac devices
US8257428B2 (en) 1999-08-09 2012-09-04 Cardiokinetix, Inc. System for improving cardiac function
US20030109770A1 (en) * 1999-08-09 2003-06-12 Sharkey Hugh R. Device with a porous membrane for improving cardiac function
US20030105384A1 (en) * 1999-08-09 2003-06-05 Sharkey Hugh R. Method of improving cardiac function using a porous membrane
US20090062601A1 (en) * 1999-08-09 2009-03-05 Alexander Khairkhahan System for improving cardiac function
US20030163191A1 (en) * 1999-08-09 2003-08-28 Nikolic Serjan D. Method for improving cardiac function
US20100121132A1 (en) * 1999-08-09 2010-05-13 Serjan Nikolic Cardiac device and methods of use thereof
US8672827B2 (en) 1999-08-09 2014-03-18 Cardiokinetix, Inc. Cardiac device and methods of use thereof
US9872767B2 (en) 1999-08-09 2018-01-23 Edwards Lifesciences Corporation Retrievable cardiac devices
US9017394B2 (en) 1999-08-09 2015-04-28 Cardiokinetix, Inc. Retrievable cardiac devices
US7279007B2 (en) 1999-08-09 2007-10-09 Cardioklnetix, Inc. Method for improving cardiac function
US8500795B2 (en) 1999-08-09 2013-08-06 Cardiokinetix, Inc. Retrievable devices for improving cardiac function
US20100048987A1 (en) * 1999-08-09 2010-02-25 Alexander Khairkhahan Retrievable cardiac devices
US7674222B2 (en) 1999-08-09 2010-03-09 Cardiokinetix, Inc. Cardiac device and methods of use thereof
US8377114B2 (en) 1999-08-09 2013-02-19 Cardiokinetix, Inc. Sealing and filling ventricular partitioning devices to improve cardiac function
US20070213578A1 (en) * 1999-08-09 2007-09-13 Alexander Khairkhahan System for improving cardiac function
US20060264980A1 (en) * 1999-08-09 2006-11-23 Alexander Khairkhahan System for improving cardiac function
US20100262168A1 (en) * 1999-08-09 2010-10-14 Alexander Khairkhahan Sealing and filling ventricular partitioning devices to improve cardiac function
US8500790B2 (en) 1999-08-09 2013-08-06 Cardiokinetix, Inc. Retrievable cardiac devices
US8388672B2 (en) 1999-08-09 2013-03-05 Cardiokinetix, Inc. System for improving cardiac function by sealing a partitioning membrane within a ventricle
US20070161846A1 (en) * 1999-08-09 2007-07-12 Serjan Nikolic Cardiac device and methods of use thereof
US20090054723A1 (en) * 1999-08-09 2009-02-26 Alexander Khairkhahan Retrievable devices for improving cardiac function
US6852076B2 (en) 1999-08-09 2005-02-08 Cardiokinetix, Inc. Method for improving cardiac function
US8747454B2 (en) 1999-08-09 2014-06-10 Cardiokinetix, Inc. System for improving cardiac function
US20030050682A1 (en) * 1999-08-09 2003-03-13 Sharkey Hugh R. Device for improving cardiac function
US20140179993A1 (en) * 1999-08-09 2014-06-26 Miles D. Alexander Systems and methods for improving cardiac function
US20070213815A1 (en) * 1999-08-09 2007-09-13 Alexander Khairkhahan System for improving cardiac function
US8192478B2 (en) 1999-08-09 2012-06-05 Cardiokinetix, Inc. System for improving cardiac function
US6293951B1 (en) * 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US20150157442A1 (en) * 1999-08-27 2015-06-11 Covidien Lp Slideable vascular filter
US9649184B2 (en) * 1999-08-27 2017-05-16 Covidien Lp Slidable vascular filter
US8529583B1 (en) 1999-09-03 2013-09-10 Medtronic, Inc. Surgical clip removal apparatus
US6911037B2 (en) 1999-09-07 2005-06-28 Ev3, Inc. Retrievable septal defect closure device
US7377936B2 (en) 1999-09-07 2008-05-27 Ev3, Inc. Retrievable septal defect closure device
US20050033327A1 (en) * 1999-09-07 2005-02-10 John Gainor Retrievable septal defect closure device
US20050055049A1 (en) * 1999-09-13 2005-03-10 Mcguckin James F. Vascular closure
US7942888B2 (en) 1999-09-13 2011-05-17 Rex Medical, L.P. Vascular hole closure device
US7341595B2 (en) 1999-09-13 2008-03-11 Rex Medical, L.P Vascular hole closure device
US20140142622A1 (en) * 1999-09-13 2014-05-22 Rex Medical, L.P. Vascular hole closure device
US6949107B2 (en) 1999-09-13 2005-09-27 Rex Medical, Lp Injection method for locating vessel lumen
US20050033326A1 (en) * 1999-09-13 2005-02-10 Briganti Richard T. Vascular hole closure device
US7267679B2 (en) 1999-09-13 2007-09-11 Rex Medical, L.P Vascular hole closure device
US8597324B2 (en) * 1999-09-13 2013-12-03 Rex Medical L.P. Vascular hole closure device
US8128653B2 (en) 1999-09-13 2012-03-06 Rex Medical, L.P. Vascular hole closure device
US20060155327A1 (en) * 1999-09-13 2006-07-13 Briganti Richard T Vascular hole closure device
US8083766B2 (en) 1999-09-13 2011-12-27 Rex Medical, Lp Septal defect closure device
US7662168B2 (en) 1999-09-13 2010-02-16 Rex Medical, L.P. Vascular closure
US20100305588A1 (en) * 1999-09-13 2010-12-02 Briganti Richard T Vascular hole closure device
US20070293880A1 (en) * 1999-09-13 2007-12-20 Rex Medical Vascular hole closure device
US6749622B2 (en) 1999-09-13 2004-06-15 Rex Medical, L.P. Vascular closure
US20030144695A1 (en) * 1999-09-13 2003-07-31 Mcguckin James F. Vascular hole closure device
US7662161B2 (en) 1999-09-13 2010-02-16 Rex Medical, L.P Vascular hole closure device
US20060276839A1 (en) * 1999-09-13 2006-12-07 Rex Medical Septal defect closure device
US9968345B2 (en) * 1999-09-13 2018-05-15 Rex Medical, L.P. Vascular hole closure device
US8603108B2 (en) 1999-09-20 2013-12-10 Atritech, Inc. Method of closing an opening in a wall of the heart
US6712804B2 (en) 1999-09-20 2004-03-30 Ev3 Sunnyvale, Inc. Method of closing an opening in a wall of the heart
US6458100B2 (en) 1999-09-20 2002-10-01 Appriva Medical, Inc. Atrial septal defect closure catheter
US9089313B2 (en) * 1999-09-20 2015-07-28 Atritech, Inc. Method of closing an opening in a wall of the heart
US6419669B1 (en) 1999-09-20 2002-07-16 Appriva Medical, Inc. Method and apparatus for patching a tissue opening
US20150313604A1 (en) * 1999-09-20 2015-11-05 Atritech, Inc. Method of closing an opening in a wall of the heart
US9277903B2 (en) 1999-09-20 2016-03-08 Nuvasive, Inc. Annulotomy closure device and related methods
US7901430B2 (en) 1999-09-20 2011-03-08 Nuvasive, Inc. Annulotomy closure device and related methods
EP1852141A2 (en) 1999-09-20 2007-11-07 ev3 Endovascular, Inc. Method and apparatus for closing a body lumen
US20040186486A1 (en) * 1999-09-20 2004-09-23 Ev3 Sunnyvale, Inc. Method of closing an opening in a wall of the heart
US6964674B1 (en) * 1999-09-20 2005-11-15 Nuvasive, Inc. Annulotomy closure device
US6702825B2 (en) 1999-09-20 2004-03-09 Ev3 Sunnyvale, Inc. Anastomosis catheter
US20070265641A1 (en) * 1999-09-20 2007-11-15 Roue Chad C Method of closing an opening in a wall of the heart
US20140100606A1 (en) * 1999-09-20 2014-04-10 Atritech, Inc. Method of closing an opening in a wall of the heart
US7549983B2 (en) 1999-09-20 2009-06-23 Atritech, Inc. Method of closing an opening in a wall of the heart
US6436088B2 (en) 1999-09-20 2002-08-20 Appriva Medical, Inc. Method and apparatus for closing a subcutaneous tissue opening
US9421004B2 (en) * 1999-09-20 2016-08-23 Atritech Inc. Method of closing an opening in a wall of the heart
US6561969B2 (en) 1999-09-20 2003-05-13 Ev3 Inc. Method of reducing the volume of the heart
US7427279B2 (en) 1999-09-20 2008-09-23 Atritech, Inc. Method of closing an opening in a wall of a heart
US6641557B1 (en) 1999-09-20 2003-11-04 Ev3 Sunnyvale, Inc. Method and apparatus for closing a body lumen
US7115110B2 (en) * 1999-09-20 2006-10-03 Ev3 Sunnyvale, Inc. Method and apparatus for closing a body lumen
US6746472B2 (en) 1999-09-20 2004-06-08 Ev3 Sunnyvale, Inc. Endoluminal anchor
US20080071301A1 (en) * 1999-09-20 2008-03-20 Nuvasive, Inc. Annulotomy closure device and related methods
US6290674B1 (en) 1999-09-20 2001-09-18 Appriva Medical, Inc. Method and apparatus for closing intracardiac septal defects
US20040220595A1 (en) * 1999-09-20 2004-11-04 Frazier Andrew G.C. Method of securing tissue
US20040098047A1 (en) * 1999-09-20 2004-05-20 Frazier Andrew G.C. Method and apparatus for closing a body lumen
US7780683B2 (en) * 1999-09-20 2010-08-24 Roue Chad C Method of closing an opening in a wall of the heart
WO2001021247A1 (en) 1999-09-20 2001-03-29 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US8197496B2 (en) * 1999-09-20 2012-06-12 Atritech, Inc. Method of closing an opening in a wall of the heart
US20050155612A1 (en) * 1999-09-20 2005-07-21 Nuvasive, Inc. Annulotomy closure device and related methods
US20080140108A1 (en) * 1999-09-20 2008-06-12 Nuvasive, Inc Annulotomy closure device and related methods
US7025756B2 (en) 1999-09-20 2006-04-11 Ev 3 Sunnyvale, Inc. Method of securing tissue
US7883527B2 (en) 1999-09-20 2011-02-08 Nuvasive, Inc. Annulotomy closure device and related methods
US6939361B1 (en) 1999-09-22 2005-09-06 Nmt Medical, Inc. Guidewire for a free standing intervascular device having an integral stop mechanism
US7935147B2 (en) 1999-10-20 2011-05-03 Anulex Technologies, Inc. Method and apparatus for enhanced delivery of treatment device to the intervertebral disc annulus
US7922768B2 (en) 1999-10-20 2011-04-12 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and deformable spinal disc annulus stent
US7670379B2 (en) 1999-10-20 2010-03-02 Anulex Technologies, Inc. Spinal disc annulus reconstruction method
US7985257B2 (en) 1999-10-20 2011-07-26 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US8048160B2 (en) 1999-10-20 2011-11-01 Anulex Technologies, Inc. Intervertebral disc annulus stent
US7951201B2 (en) 1999-10-20 2011-05-31 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US9095442B2 (en) 1999-10-20 2015-08-04 Krt Investors, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US7993405B2 (en) 1999-10-20 2011-08-09 Anulex Technologies, Inc. Spinal disc annulus repair system and methods
US9114025B2 (en) 1999-10-20 2015-08-25 Krt Investors, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US7963992B2 (en) 1999-10-20 2011-06-21 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US8088165B2 (en) 1999-10-20 2012-01-03 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and deformable spinal disc annulus stent
US9675347B2 (en) 1999-10-20 2017-06-13 Krt Investors, Inc. Apparatus for the treatment of tissue
US7909879B2 (en) 1999-10-20 2011-03-22 Anulex Technologies, Inc. Intervertebral disc annulus stent
US8128698B2 (en) 1999-10-20 2012-03-06 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US7749273B2 (en) 1999-10-20 2010-07-06 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US8556977B2 (en) 1999-10-20 2013-10-15 Anulex Technologies, Inc. Tissue anchoring system and method
US7615076B2 (en) 1999-10-20 2009-11-10 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US7189235B2 (en) 1999-10-20 2007-03-13 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
US7828850B2 (en) 1999-10-20 2010-11-09 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US8034112B2 (en) 1999-10-20 2011-10-11 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
US8632590B2 (en) 1999-10-20 2014-01-21 Anulex Technologies, Inc. Apparatus and methods for the treatment of the intervertebral disc
US20040049210A1 (en) * 1999-10-27 2004-03-11 Vantassel Robert A. Filter apparatus for ostium of left atrial appendage
EP1223890B1 (en) * 1999-10-27 2004-04-21 Atritech, Inc. Barrier device for covering the ostium of left atrial appendage
US20040127935A1 (en) * 1999-10-27 2004-07-01 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6730108B2 (en) 1999-10-27 2004-05-04 Atritech, Inc. Barrier device for ostium of left atrial appendage
US9132000B2 (en) 1999-10-27 2015-09-15 Atritech Inc. Filter apparatus for ostium of left atrial appendage
US7727189B2 (en) 1999-10-27 2010-06-01 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6652555B1 (en) 1999-10-27 2003-11-25 Atritech, Inc. Barrier device for covering the ostium of left atrial appendage
US8685055B2 (en) 1999-10-27 2014-04-01 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6652556B1 (en) 1999-10-27 2003-11-25 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6949113B2 (en) 1999-10-27 2005-09-27 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6689150B1 (en) 1999-10-27 2004-02-10 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
EP1227770B1 (en) * 1999-10-27 2004-09-15 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US20050049573A1 (en) * 1999-10-27 2005-03-03 Atritech, Inc. Barrier device for ostium of left atrial appendage
US8221445B2 (en) 1999-10-27 2012-07-17 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6551303B1 (en) 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US20030204203A1 (en) * 1999-11-08 2003-10-30 Ev3 Sunnyvale, Inc., A California Corporation Adjustable left atrial appendage implant
US7192439B2 (en) 1999-11-08 2007-03-20 Ev3 Endovascular, Inc. Method of removing an implanted device
US8663273B2 (en) * 1999-11-08 2014-03-04 Atritech, Inc. Method of implanting an adjustable occlusion device
US20030212432A1 (en) * 1999-11-08 2003-11-13 Ev3 Sunnyvale, Inc., A California Corporation Method of removing an implanted device
US20040034366A1 (en) * 1999-11-08 2004-02-19 Ev3 Sunnyvale, Inc., A California Corporation Device for containing embolic material in the LAA having a plurality of tissue retention structures
US8043329B2 (en) 1999-11-08 2011-10-25 Atritech, Inc. Method of implanting an adjustable occlusion device
US20140148842A1 (en) * 1999-11-08 2014-05-29 Atritech, Inc. Method of implanting an adjustable occlusion device
US8323309B2 (en) * 1999-11-08 2012-12-04 Atritech, Inc. Adjustable left atrial appendage implant
US6994092B2 (en) 1999-11-08 2006-02-07 Ev3 Sunnyvale, Inc. Device for containing embolic material in the LAA having a plurality of tissue retention structures
US8287563B2 (en) 1999-11-08 2012-10-16 Atritech, Inc. Implant retrieval system
US9943299B2 (en) * 1999-11-08 2018-04-17 Atritech, Inc. Method of implanting an adjustable occlusion device
US20060206148A1 (en) * 1999-11-08 2006-09-14 Khairkhahan Alexander K Method of implanting an adjustable occlusion device
US20040220610A1 (en) * 1999-11-08 2004-11-04 Kreidler Marc S. Thin film composite lamination
US7044134B2 (en) 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
US6387104B1 (en) 1999-11-12 2002-05-14 Scimed Life Systems, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US8628543B2 (en) 1999-11-12 2014-01-14 Boston Scientific Scimed, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US7918864B2 (en) 1999-11-12 2011-04-05 Boston Scientific Scimed, Inc. Apparatus for endoscopic repair of the lower esophageal sphincter
US20050149074A1 (en) * 1999-11-12 2005-07-07 Scimed Life Systems, Inc. Apparatus for endoscopic repair of the lower esophageal sphincter
US20110208219A1 (en) * 1999-11-12 2011-08-25 Boston Scientific Scimed, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US9247939B2 (en) 1999-11-12 2016-02-02 Boston Scientific Scimed, Inc. Methods and devices for manipulating tissue
US6837894B2 (en) 1999-11-12 2005-01-04 Scimed Life Systems, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US8876896B2 (en) 1999-11-17 2014-11-04 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8721708B2 (en) 1999-11-17 2014-05-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8998979B2 (en) 1999-11-17 2015-04-07 Medtronic Corevalve Llc Transcatheter heart valves
US8603159B2 (en) 1999-11-17 2013-12-10 Medtronic Corevalve, Llc Prosthetic valve for transluminal delivery
US8801779B2 (en) 1999-11-17 2014-08-12 Medtronic Corevalve, Llc Prosthetic valve for transluminal delivery
US9962258B2 (en) 1999-11-17 2018-05-08 Medtronic CV Luxembourg S.a.r.l. Transcatheter heart valves
US7892281B2 (en) 1999-11-17 2011-02-22 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8986329B2 (en) 1999-11-17 2015-03-24 Medtronic Corevalve Llc Methods for transluminal delivery of prosthetic valves
US9066799B2 (en) 1999-11-17 2015-06-30 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US20080133003A1 (en) * 1999-11-17 2008-06-05 Jacques Seguin Prosthetic valve for transluminal delivery
US9060856B2 (en) 1999-11-17 2015-06-23 Medtronic Corevalve Llc Transcatheter heart valves
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US9421100B2 (en) 1999-12-31 2016-08-23 ABPS Venture One, Ltd., a wholly owned subsidiary of Palmaz Scientific, Inc. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US7338520B2 (en) * 1999-12-31 2008-03-04 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US8221493B2 (en) 1999-12-31 2012-07-17 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US8992597B2 (en) 1999-12-31 2015-03-31 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20030023300A1 (en) * 1999-12-31 2003-01-30 Bailey Steven R. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US8758396B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US9050087B2 (en) 2000-01-05 2015-06-09 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US7828817B2 (en) * 2000-01-05 2010-11-09 Integrated Vascular Systems, Inc. Apparatus and methods for delivering a closure device
US20050273136A1 (en) * 2000-01-05 2005-12-08 Integrated Vascular Systems, Inc. Apparatus and methods for delivering a closure device
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US7901428B2 (en) 2000-01-05 2011-03-08 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US8956388B2 (en) 2000-01-05 2015-02-17 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant
US7931669B2 (en) 2000-01-05 2011-04-26 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US7819895B2 (en) 2000-01-05 2010-10-26 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US9949831B2 (en) 2000-01-19 2018-04-24 Medtronics, Inc. Image-guided heart valve placement
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US6547806B1 (en) * 2000-02-04 2003-04-15 Ni Ding Vascular sealing device and method of use
US20060142218A1 (en) * 2000-02-18 2006-06-29 Kunihiro Ohta Method of controlling telomere length
US7662181B2 (en) 2000-03-04 2010-02-16 Pulmonx Corporation Methods and devices for use in performing pulmonary procedures
US20040134487A1 (en) * 2000-03-04 2004-07-15 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US6694979B2 (en) 2000-03-04 2004-02-24 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US6679264B1 (en) 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US6840243B2 (en) 2000-03-04 2005-01-11 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US8474460B2 (en) 2000-03-04 2013-07-02 Pulmonx Corporation Implanted bronchial isolation devices and methods
US8357139B2 (en) 2000-03-04 2013-01-22 Pulmonx Corporation Methods and devices for use in performing pulmonary procedures
US20060174870A1 (en) * 2000-03-04 2006-08-10 Deem Mark E Methods and devices for use in performing pulmonary procedures
US7165548B2 (en) 2000-03-04 2007-01-23 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US6901927B2 (en) 2000-03-04 2005-06-07 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US20110226238A1 (en) * 2000-03-04 2011-09-22 Pulmonx Corporation Implanted bronchial isolation devices and methods
US20030192551A1 (en) * 2000-03-04 2003-10-16 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US6904909B2 (en) 2000-03-04 2005-06-14 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US20050051163A1 (en) * 2000-03-04 2005-03-10 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US8353092B2 (en) 2000-03-31 2013-01-15 Medtronic, Inc. Multiple bias surgical fastener
US7896892B2 (en) 2000-03-31 2011-03-01 Medtronic, Inc. Multiple bias surgical fastener
US6596012B2 (en) 2000-04-19 2003-07-22 Radi Medical Systems Ab Intra-arterial occluder
US6214029B1 (en) * 2000-04-26 2001-04-10 Microvena Corporation Septal defect occluder
US20030195530A1 (en) * 2000-04-26 2003-10-16 Microvena Corporation, A Minnesota Corporation, And Into Ev3 Inc., A Delaware Corpora Septal defect occluder
US6551344B2 (en) 2000-04-26 2003-04-22 Ev3 Inc. Septal defect occluder
US20030078500A1 (en) * 2000-05-09 2003-04-24 Rami Evron System and method for three-dimensional reconstruction of an artery
US7758606B2 (en) 2000-06-30 2010-07-20 Medtronic, Inc. Intravascular filter with debris entrapment mechanism
US8777980B2 (en) 2000-06-30 2014-07-15 Medtronic, Inc. Intravascular filter with debris entrapment mechanism
US8092487B2 (en) 2000-06-30 2012-01-10 Medtronic, Inc. Intravascular filter with debris entrapment mechanism
EP2158847A1 (en) 2000-07-28 2010-03-03 ev3 Endovascular, Inc. Occluder delivery system
US6440152B1 (en) 2000-07-28 2002-08-27 Microvena Corporation Defect occluder release assembly and method
US20020198563A1 (en) * 2000-07-28 2002-12-26 Microvena Corporation Defect occluder release assembly & method
US7479155B2 (en) 2000-07-28 2009-01-20 Ev3 Endovascular, Inc. Defect occluder release assembly and method
US20110087066A1 (en) * 2000-08-09 2011-04-14 Boutillette Michael P Devices and methods for delivering an endocardial device
US9078660B2 (en) 2000-08-09 2015-07-14 Cardiokinetix, Inc.<