US20040102855A1 - Anti-reflux stent - Google Patents

Anti-reflux stent Download PDF

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US20040102855A1
US20040102855A1 US10/302,781 US30278102A US2004102855A1 US 20040102855 A1 US20040102855 A1 US 20040102855A1 US 30278102 A US30278102 A US 30278102A US 2004102855 A1 US2004102855 A1 US 2004102855A1
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stent
tube
weave
inner sleeve
anti
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US10/302,781
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Peter Shank
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Boston Scientific Scimed Inc
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Priority to US10/302,781 priority Critical patent/US20040102855A1/en
Assigned to SCIMED LIFE SYSTEMS, INC. reassignment SCIMED LIFE SYSTEMS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SHANK, PETER J.
Publication of US20040102855A1 publication Critical patent/US20040102855A1/en
Assigned to BOSTON SCIENTIFIC SCIMED, INC. reassignment BOSTON SCIENTIFIC SCIMED, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: SCIMED LIFE SYSTEMS, INC.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/044Oesophagi or esophagi or gullets
    • AHUMAN NECESSITIES
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/072Encapsulated stents, e.g. wire or whole stent embedded in lining
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/075Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9528Instruments specially adapted for placement or removal of stents or stent-grafts for retrieval of stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0067Three-dimensional shapes conical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0073Quadric-shaped
    • A61F2230/0078Quadric-shaped hyperboloidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001Designing or manufacturing processes

Abstract

An anti-reflux stent includes an extended inner sleeve, a stent surrounding at least a portion of the inner sleeve and a coating that bonds the stent to the inner sleeve whereby the extended inner sleeve can have a cross-sectional thickness that varies along the length of the inner sleeve. The inner sleeve is made of a material having a thickness and/or flexibility such that the distal end not surrounded by the stent collapses under gastric pressure to prevent the contents of the stomach from flowing into an esophagus. Food and liquid can pass through an inner lumen of the inner sleeve to enter a stomach when desired.

Description

    FIELD OF THE INVENTION
  • The present invention relates to medical devices in general, and to anti-reflux stents in particular. [0001]
  • BACKGROUND OF THE INVENTION
  • Gastroespohageal reflux disease (GERD) is a medical condition whereby stomach acids repeatedly enter the lower portion of the esophagus because the lower esophageal sphincter (LES) at the entrance of the stomach fails to close properly. The LES may fail to close because it is diseased or has atrophied. Alternatively, patients having cancer or a tumor in the esophagus may have the LES forced open by a stent so that food and liquids can be ingested. The reflux of stomach acids into the esophagus causes severe heartburn and may contribute to the onset of other diseases. [0002]
  • One method of relieving GERD is to place an anti-reflux stent into the entrance of the stomach. An anti-reflux stent is a device that has a one-way valve to allow food and liquid to enter the stomach but prevents liquids from passing back through the valve. Examples of anti-reflux stents can be found in J. Valbuena, “Palliation of Gastroesophageal Carcinoma with Endoscopic Insertion of a New Anti-reflux Prosthesis,” Gastrointestinal Endoscopy, Vol. 30, No. 4 pp. 241-243 (August 1994) and U.S. Pat. No. 6,302,917. [0003]
  • A conventional anti-reflux stent has a tubular sleeve that hangs into the stomach and a stent that surrounds a portion of the sleeve to provide a lumen through which food and liquids may pass. [0004]
  • In general it is desirable that an anti-reflux stent provide a smooth lumen opening into the stomach and an outer surface that will limit tissue growth into the stent such that it remains open and could be removed if desired. In addition, it is desirable that the valve characteristics that are provided by the sleeve can be easily selected during manufacture. [0005]
  • SUMMARY OF THE INVENTION
  • The present invention is an anti-reflux stent that is placed into the opening of a stomach by a physician. The anti-reflux stent includes an extended inner sleeve, a stent surrounding a portion of the inner sleeve, and a coating over the stent such that the stent is bonded to the inner sleeve. The distal end of the inner sleeve is flexible such that it compresses under normal gastric pressure in the stomach to prevent stomach contents from flowing back into the esophagus. However, under increased esophageal pressure and peristaltic action, food and liquid can pass through the sleeve in its collapsed state to enter the stomach. [0006]
  • In one embodiment of the invention, the inner sleeve has thickness and flexibility such that it inverts into the stent with sufficient gastric pressure. The proximal end of the stent may be coated to allow the stent to be removed or may be free of coating to aid in stent retention. The proximal end of the stent may be cylindrical or flared radially outward such that the stent can be embedded in or secured to an esophageal lining.[0007]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The foregoing aspects and many of the attendant advantages of this invention will become more readily appreciated as the same become better understood by reference to the following detailed description, when taken in conjunction with the accompanying drawings, wherein: [0008]
  • FIG. 1 illustrates a conventional anti-reflux esophageal stent in place in an opening of a stomach; [0009]
  • FIG. 2 is a cross-sectional view of an anti-reflux esophageal stent in a pressurized or closed position in accordance with one embodiment of the present invention; [0010]
  • FIGS. 2A, 2B illustrate one technique for removing an anti-reflux stent in accordance with the present invention; [0011]
  • FIG. 3 illustrates the proximal end of an anti-reflux esophageal stent having a flared end; [0012]
  • FIG. 4 illustrates an anti-reflux esophageal stent having a non-coated portion; [0013]
  • FIG. 5 is a flow chart showing a series of process steps used to make an anti-reflux esophageal stent in accordance with one embodiment of the invention; [0014]
  • FIG. 6 is a flow chart showing a series of process steps used to make an anti-reflux esophageal stent in accordance with another embodiment of the present invention; [0015]
  • FIG. 7 shows one embodiment of a form that creates a valve within an anti-reflux stent in accordance with another embodiment of the present invention; [0016]
  • FIG. 8[0017] a shows a tube forming the basis of the stent;
  • FIG. 8[0018] b shows a weave forming the basis of the stent;
  • FIG. 8[0019] c shows a layer forming the basis of the stent in accordance with the invention;
  • FIG. 8[0020] d is a schematic representation of the composition forming the stent in accordance with the invention comprising a tube, a weave and a coating;
  • FIG. 9 shows a schematic cross section or end view of the stent of the invention in accordance with FIG. 8[0021] d;
  • FIG. 10[0022] a shows an embodiment in accordance with the invention of capturing free filament ends using a cover cap;
  • FIG. 10[0023] b shows an additional embodiment in accordance with the invention of captured filament ends using a filament tube;
  • FIG. 10[0024] c shows an embodiment having welded filament ends;
  • FIG. 10[0025] d shows a folding-over of the tube to effect capture of the filament ends;
  • FIG. 11[0026] a shows an application device for placing the stent in accordance with the invention;
  • FIG. 11[0027] b shows an application device in accordance with FIG. 11a having an inserted stent and conical plug;
  • FIG. 11[0028] c shows an application device having a capture and displacement device turned with respect to FIG. 11a;
  • FIG. 12 shows a stent having raised portions on the outer peripheral surface formed by free ends of filament pieces; [0029]
  • FIG. 13 shows a stent having anchors introduced on the outer surface in the extended state; [0030]
  • FIG. 14 shows a stent in accordance with FIG. 13 in an expanded state. [0031]
  • FIG. 15 shows a stent having differing surface contours in dependence on axial and radial directions; and [0032]
  • FIG. 16 shows a stent in an expanded state having widened lumens at each free end region.[0033]
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
  • As indicated above, the present invention is an anti-reflux esophageal stent that allows a patient to ingest food or other liquid while preventing stomach acids from flowing back into the esophagus. FIG. 1 illustrates a conventional anti-reflux stent [0034] 10 that is placed at the entrance of a stomach 12 in the area of the lower esophageal sphincter (LES) 14. With the anti-reflux stent 10 in place, the proximal end of the stent forms a lumen into the opening of the stomach while the distal end acts to prevent the contents of the stomach 12 from entering the esophagus. The anti-reflux stent 10 comprises a flexible polymeric sleeve that collapses under the gastric pressure of the stomach 12 thereby forming a one-way valve. Food and liquid can pass in the distal direction through the collapsed sleeve but stomach acids do not flow in the proximal direction through the collapsed sleeve. However, the one-way valve can invert if the stomach pressure is sufficient to force the distal end 16 of the sleeve into the stent such as during vomiting or if the patient needs to belch. Details of the anti-reflux stent 10 are considered known to those of ordinary skill in the art and are for example disclosed in U.S. Pat. Nos. 6,302,917 and 6,162,244, which are herein incorporated by reference.
  • FIG. 2 is a cross-section view of an anti-reflux esophageal stent in accordance with one embodiment of the present invention. The anti-reflux stent [0035] 20 has an inner sleeve 22, a stent 24 surrounding a portion of the inner sleeve 22 at the proximal end, and a coating 26 over the stent 24 that bonds the stent 24 to the inner sleeve 22. The inner sleeve 22 is preferably a polymeric tube that can be manufactured in a variety of manners including extrusion, molding, or forming the sleeve on a mandrel that is dipped into a polymeric solution. The materials and dimensions of the inner sleeve 22 are selected such that it will collapse in the area where it is not supported by the stent 24. Therefore, the sleeve 22 forms a one-way valve for passage of food or liquids into the stomach of a patient. Representative materials for the inner sleeve 22 include silicone, urethane or other flexible, bio-compatible materials.
  • In accordance with the present invention, the closure characteristics of the one-way valve can be tailored by the selection of the materials and/or dimensions of the inner sleeve. The sleeve may have different dimensions or thicknesses along its length. For example, the sleeve might be thicker in the portion that is covered by the stent and thinner at the portion that is not covered by the stent. In yet another embodiment, the inner sleeve may be made of different layers along its length by coating the inner sleeve with different materials such as silicone, polyurethane, or other surface enhancing, friction reducing or other modifying coatings. Furthermore, the sleeve could be extruded using two or more different materials in order to tailor the characteristics of the inner sleeve along its length. [0036]
  • The stent [0037] 24 bonded to the inner sleeve 22 may be a braided or knitted stent made from a variety of materials including polyester, nylon, stainless steel, Nitinol™ brand metal alloy, Kevlar™ or other materials that provide sufficient rigidity and strength. The stent is preferably self expanding but could be expandable by a balloon or other device. Examples of particular stents that could be used in an anti-reflux stent of the present invention are set forth in U.S. Pat. Nos. 4,954,126 and 4,655,771, which are herein incorporated by reference.
  • To bond the stent [0038] 24 to the inner sleeve 22, a coating 26 covers the stent 24. The coating covers the fibers that comprise the stent thereby sealing it to the inner sleeve 22. To obtain the best possible adhesion, it is believed that the coating 26 should be made of the same material as the inner sleeve 22. Therefore, if the inner sleeve 22 is made of a silicone material, then the coating 26 should be similarly made of a silicone material. Alternatively, if the inner tube 22 is made from a urethane material, then the coating 26 should also be made of a urethane-type material. While the use of similar materials is believed to be preferred, other materials may provide sufficient strength and bonding properties to coat the stent and adhere it to the outer surface of the inner sleeve 22. Various thicknesses of the outer coating can be made by varying the dipping rate or building up a coating as a number of different layers.
  • As shown in FIG. 2A, the majority of the stent [0039] 24 is covered by a coating 26. At the proximal end of the stent are a number of bare wire or thread loops 30 that allow the anti-reflux stent to be retrieved from the patient.
  • As shown in FIG. 2B, to retrieve the stent, a catheter [0040] 32 is inserted into the esophagus and a suture is passed through a lumen of the catheter and through a number of the loops 30 to cinch the proximal end of the stent closed. With the proximal end of the stent 24 cinched, its diameter is decreased and the endoscope and anti-reflux stent can be withdrawn from the patient's esophagus. Alternatively, the cinched anti-reflux stent may be fully or partially retracted into a retrieval tube prior to being withdrawn from the patient. The coating 26 over the stent 24 limits the ingrowth of tissue into the stent and may be lubricous to aid in its removal.
  • In the example shown in FIG. 2, the proximal end of the stent [0041] 24 has a generally cylindrical cross-section. However the diameter of the stent may vary along its length. For example, the proximal end of the stent may be flared radially outward such as that shown in FIG. 3. The flared proximal end 40 extends radially outward and may provide additional ability to hold the stent in place within the esophagus.
  • In yet another embodiment of the invention, the proximal end of the stent [0042] 24 does not overlap with the inner sleeve 22. That is, the proximal end of the stent 24 comprises a length of bare mesh. If the proximal end of the stent is not coated, tissue may grow into the interstitial spaces between the fibers or wires that comprise the stent thereby acting to secure the stent within the esophagus if desired. Alternatively, the physician can put a suture or other attachment mechanisms through the exposed portion of the stent to help maintain its position within the esophagus.
  • FIG. 5 shows a series of process steps that can be used to manufacture an anti-reflux stent in accordance with one embodiment of the invention. [0043]
  • Beginning at a block [0044] 50, an extrusion that forms the inner sleeve is placed over a mandrel. At a block 52, a stent is placed over the proximal end of the extrusion. At a block 54, a coating is formed over the stent to secure it to the extruded inner sleeve. The coating may be formed by dipping the portion of the mandrel including the stent into a 2-part silicone bath or other coating material. Alternatively, the coating may be formed by spraying it or molding it over the stent. The mandrel is then removed from the inner diameter of the inner sleeve.
  • FIG. 6 shows an alternate series of process steps that can be used to make an anti-reflux stent in accordance with the present invention. Beginning at a block [0045] 60, an inner sleeve is created on a mandrel by dipping it in a material such as silicone or urethane bath. With the inner sleeve created on the mandrel, a stent is placed over the proximal end of the inner sleeve at a block 62. The exterior of the stent is then coated at a block 64 by dipping the mandrel including the stent into a material such as 2-part silicone or urethane bath. Alternatively, the coating can be applied by spraying or molding it over the stent. The mandrel is then removed from the inner sleeve.
  • In some embodiments, it may be desirable to add one or more valves to the anti-reflux stent. FIG. 7 illustrates one method of creating a set of valves in an anti-reflux stent [0046] 70. The anti-reflux stent has an inner sleeve 72, a stent 74 covering a portion of the inner sleeve 72 and a coating 76 that bonds the stent 74 to the inner sleeve 72. A set of valve flaps 78 a, 78 b, 78 c can be formed in an inner lumen of the inner sleeve 72 by inserting a form 79 into the inner lumen. The form has a divider 80 that divides the area of the lumen into sections. With the form 79 in place, the anti-reflux stent is dipped into a polymeric solution and the divider 80 creates valve flaps that are bonded to the interior lumen of the inner sleeve. The one or more valve flaps created when the form 79 is removed from the stent 70 further prevent the reflux of stomach acids into the esophagus. The valve flaps can be positioned anywhere along the length of the stent but may be advantageously positioned to align with an LES when the stent is installed.
  • FIGS. 8[0047] a-8 d illustrate the construction of a stent 100 in accordance with the invention. The stent 100 consists essentially of an inner sleeve 102 (see FIG. 8a) made from elastic material, a tubular weave 103 tightly seating on the outer surface of the inner sleeve 102 (see FIG. 8b) and woven together from a plurality of filaments 105, as well as a coating 104 (FIG. 8c) introduced onto the outer surface of the inner sleeve 102. FIG. 8d shows the stent 100 in the constructed state. The inner sleeve 102 has a smooth inner surface and is strengthened through integration with the weaving 103 comprising the filaments 105, wherein the tubular weaving 103 and the inner sleeve 102 are joined by means of the coating 104. In accordance with FIG. 8d, the coating 104 is constructed in such a fashion that the prominent structure caused by the filaments 105 on the outer surface of the tube 102 projects through the coating 104 to lead to a structured outer surface of the coating 104.
  • FIG. 9 shows a schematic cross-section or end view of the stent in accordance with the invention. The inner sleeve [0048] 102 as well as the weave 103, comprising the filaments 105 and tightly seating on the outer surface of the inner sleeve 102, are bonded together by means of the relatively thin coating 104. In the embodiment in accordance with FIG. 9, the stent 100 has a structured outer surface dominated by the filaments 105 of rounded cross-section on the outer surface of the inner sleeve 102. The coating 104 is thereby sufficiently thin that the spaces between the filaments 105 are not completely filled up, wherein the structure dominated by the filaments 105 at the outer surface of the inner sleeve 102 is simply covered in a sealed fashion using the coating 104.
  • The embodiments in accordance with FIGS. 10[0049] a-10 d show different ways of holding the filament ends 109 together. In FIG. 10a, the ends 109 of the filaments 105 are connected to each other in a protected fashion using a cover cap 106. In accordance with FIG. 10b, the ends 109 of the filaments 105 are each connected to each other by means of a common filament tube 107. The free ends 109 of the filament 105 in accordance with FIG. 10c are held together and captured by means of a weldment 108. In accordance with FIG. 10d, it is also possible to capture the free ends of the filament 105 by means of a folding-over 120 of the inner sleeve 102.
  • FIGS. 11[0050] a and 11 b show an application device 110 which is suitable for introducing the stent 100 into a body cavity. The application device 110 in accordance with FIGS. 11a and 11 b consists essentially of an outer application bushing 115 as well as an inner capture and displacement device 111. The inner capture and displacement device 111 has a spread-out capture device 112 at one end and is configured smoothly at the end opposite to the capture device 112. In addition, the capture and displacement device 111 has a lumen 114. In FIG. 11a, the stent 100 is pulled into the application device 110 in the direction of arrow 121 using the spread-out end of the capture device 112. The outer diameter of the capture and displacement device 111 is thereby dimensioned in such a fashion that it can be displaced within a lumen 113 of the application bushing 115. In accordance with FIG. 11c, a stent 100 which is already captured using the capture and displacement device 111 is displaced in the direction of arrow 122 out of the application bushing 115 and positioned within a body cavity.
  • In order to utilize the application device in accordance with FIGS. 11[0051] a, 11 b and 11 c, the stent is initially pulled into the application bushing 115 in accordance with FIG. 11a by means of the spread-out end 112 of the capture and displacement device 111. After the stent 100 is completely within the application bushing 115 in accordance with FIG. 11b the stent 100 is positioned within the lumen 113 of the application bushing 115 by means of the conical plug 116. A guided motion of the capture device 112 in the direction of arrow 121 then frees the stent 100. The conical plug 116 is removed from the application bushing 115 and the capture and displacement device 111 is pulled out of the application bushing 115, turned around and once more inserted into the application bushing 115 at its other end (see FIG. 11c). Optical observation of the placing of the stent 100 is facilitated by an instrument which can be guided through a lumen 114. The application device 110 is subsequently placed and situated within the body cavity through displacement of the capture and displacement device 111.
  • FIG. 12 shows a stent [0052] 150 which is formed from a tube 151, a weave 152 and a coating 153. In addition to filament threads 154 from which the weave 152 is produced, a second filament thread 155 is adjacent to the threads 154 and is interrupted in sections, the free ends 156 of which protrude above the weave 152 and the coating 153. The free ends 156 build hooks for tissue adjacent to the outer surface of the stent.
  • FIG. 13 shows another embodiment of a stent [0053] 160, in the elongated state, which has a weave 162. Anchors 165 are introduced on a flat section of outer surface 164 of the stent 166. Each anchor 165 is connected to the outer surface 164 of the stent 160 in a position-stable manner via first end 166. A second end 167 seats on the outer surface 164 of the stent 160. The stent 160 is elongated in the direction of arrow 168.
  • FIG. 14 shows the stent [0054] 160 of FIG. 13 in an expanded state. The stent 160 expands in the direction of arrow 171 so that an increased lumen 172 results. During expansion, the second ends 167 of the anchors 165 “stand up” and become separated from the outer surface 164. The second ends 167 facilitate the hooking or digging of the anchors 165 of the stent 160 into an adjacent surface.
  • FIG. 15 shows a stent [0055] 180 which likewise consists essentially of a tube 181, a weave 182 and a coating 183. The shape of the stent 180 differs in dependence on its axial and radial dimensions. The stent 180 assumes a distended shape 184 in an expanded state. The distended shape 184 is effected by weaving the weave 182 over a mould having this distended contour 184. The shape can be arbitrary and can be adjusted to the application. The distended shape 164 shown in FIG. 11 can be fashioned in a permanent manner using thermal shaping techniques.
  • FIG. 16 shows an additional embodiment of a stent [0056] 190, consisting essentially of a tube 191 supporting a weave 192 covered by a coating 193. As seen from the side, the outer shape of the stent 190 has a concave dependence 194 along its axial extent so that the stent 190 has free ends 195, 196 which define a wider lumen in both end regions of the stent 190. The free ends 195, 196 can be reinforced by means of ring structures on the outer surface of the stent 190. These ring structures can also be introduced on arbitrary sections of the stent at the outer surface thereof independent of the embodiment of FIG. 16.
  • The invention concerns a stent [0057] 100 for the bracing and/or holding-open of a body cavity having a tube 102 made from an elastic material, a tubular weave 113 comprising filaments 105 seating in close adjacency to the outer surface of the inner sleeve 102 as well as a coating 104 applied to the outer surface of the inner sleeve 102 which attaches the weave 103 to the outer surface of the inner sleeve 102. The coating 104 is adapted to have a structured outer surface dominated by the weave 103. The stent 100 in accordance with the invention can be produced economically with adjustable restoring forces and facilitates a secure placing within a body cavity. Means for preventing drifting within the body cavity can also be introduced onto the outer surface of the stent. In each of the FIGS. 8-16, an anti-reflux stent is created by lengthening the inner sleeve such that it is longer than the stent. With the sleeve sufficiently long, it will collapse in the stomach thereby forming a one-way valve to allow the passage of food and fluids into the stomach but prevent stomach acids from flowing back into the esophagus.
  • While the preferred embodiment of the invention has been illustrated and described, it will be appreciated that various changes can be made therein without departing from the spirit and scope of the invention. [0058]

Claims (20)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
1. An anti-reflux stent, comprising:
an inner sleeve;
a stent covering at least a portion of the inner sleeve;
a coating on the stent to bond the stent to an exterior of the inner sleeve;
wherein said inner sleeve includes a lumen through which food and liquid may pass and wherein at least a portion of the inner sleeve has a flexibility such that it collapses where the inner sleeve is not covered by the stent.
2. The anti-reflux stent of claim 1, wherein all the stent is coated.
3. The anti-reflux stent of claim 1, wherein a portion of the stent is not coated.
4. The anti-reflux stent of claim 1, wherein the proximal end of the stent is flared radially outwards.
5. An anti-reflux stent for deployment in an opening of a patient's stomach, comprising:
an inner sleeve having a proximal end, a distal end and a lumen extending therethrough;
a stent covering at least a portion of the proximal end of the inner sleeve and not covering the distal end of the inner sleeve;
a coating that bonds the stent to the inner sleeve;
wherein the anti-reflux stent is adapted to be deployed in an entrance to the stomach such that the stent maintains the lumen of the inner sleeve open so food and liquid can pass into the stomach and the distal end of the sleeve collapses due to pressure in the stomach to prevent reflux into the esophagus.
6. An anti-reflux stent, comprising:
an inner sleeve having a proximal end, a distal end and a lumen extending therethrough;
a stent that covers a proximal portion of the inner sleeve and does not cover a distal portion of the inner sleeve; and
a coating that bonds the stent to the inner sleeve, wherein the portion of the inner sleeve that is not covered collapses to form a one-way valve.
7. The anti-reflux stent of claim 6, wherein the inner sleeve includes one or more valve flaps formed in a lumen of the inner sleeve.
8. The anti-reflux stent of claim 6, wherein the inner sleeve has different flexibility characteristics along its length.
9. The anti-reflux stent of claim 6, wherein the inner sleeve has a varying thickness along its length.
10. The anti-reflux system of claim 6 wherein the inner sleeve is made of different materials along its length.
11. The anti-reflux stent of claim 6, wherein the anti-reflux stent is removable.
12. The anti-reflux stent of claim 6, wherein the proximal end of the stent has a mechanism for allowing the stent to be grasped and removed from a patient.
13. The anti-reflux of claim 12, wherein the mechanism for allowing a stent to be grasped includes a number of exposed loops at the proximal end of the stent.
14. The anti-reflux stent of claim 11, wherein the coating that covers the stent is lubricous.
15. In a stent system for splitting and holding open a body cavity of the type having:
a tube made from an elastic material;
a tubular weave seating firmly on an outer surface of said tube, said weave having a filament with a diameter and;
a coating covering said tube and said weave to hold said weave on said tube, said coating having a thickness less than said filament diameter, said coating consisting essentially of a self-solidifying fluid into which said tube and said weave are dipped, whereby the stent has a structured outer surface defined by said weave, and further having an application device for introducing the stent into a body cavity, said application device including a capture and a displacement device, an application bushing, and a conical plug, the improvement comprising: a one-way valve formed by the tube having a length that extends beyond the tubular weave such that a portion of the tube that extends beyond the tubular weave collapses on itself due to pressure in the body cavity.
16. In a stent system for splitting and holding open a body cavity of the type having:
a tube made from an elastic material;
a tubular weave seating firmly on an outer surface of said tube, said weave having a filament with a diameter and;
a coating covering said tube and said weave to hold said weave on said tube, said coating having a thickness less than said filament diameter, said coating consisting essentially of a self-solidifying fluid into which said tube and said weave are dipped, whereby the stent has a structured outer surface defined by said weave, wherein said filament has a fixed end, and wherein said filament comprises a plurality of threads having neighboring ends pair-wises connected to each other and further comprising a covering element for pair-wise connecting said neighboring ends, the improvement comprising: a valve formed by the tube extending beyond the tubular weave such that the tube is collapsible in the body cavity.
17. In a stent system for splitting and holding open a body cavity of the type including:
a tube made from an elastic material;
a tubular weave seating firmly on an outer surface of said tube, said weave having a filament with a diameter and;
a coating covering said tube and said weave to hold said weave on said tube, said coating having a thickness less than said filament diameter, said coating consisting essentially of a self-solidifying fluid into which said tube and said weave are dipped, whereby the stent has a structured outer surface defined by said weave, and further comprising raised portions protruding beyond said structured outer surface, the improvement comprising: a valve formed by the tube having a length extending beyond the tubular weave and a flexibility such that the tube is compressible in the body cavity.
18. In a stent system for splitting and holding open a body cavity of the type including:
a tube made from an elastic material;
a tubular weave seating firmly on an outer surface of said tube, said weave having a filament with a diameter and;
a coating covering said tube and said weave to hold said weave on said tube, said coating having a thickness less than said filament diameter, said coating consisting essentially of a self-solidifying fluid into which said tube and said weave are dipped, whereby the stent has a structured outer surface defined by said weave, wherein said weave has shapes differing in at least one of an axial and a radial direction, the improvement comprising: an anti-reflux valve formed by the tube having a length that is longer than the tube and a flexibility that allows the tube to collapse in the body cavity.
19. In a stent system for splitting and holding open a body cavity of the type including:
a tube made from an elastic material;
a tubular weave seating firmly on an outer surface of said tube, said weave having a filament with a diameter and;
a coating covering said tube and said weave to hold said weave on said tube, said coating having a thickness less than said filament diameter, said coating consisting essentially of a self-solidifying fluid into which said tube and said weave are dipped, whereby the stent has a structured outer surface defined by said weave, wherein said tube has fold-over covering an end of said filament, the improvement comprising: an anti-reflux valve formed by the tube having a length that is longer than the tubular weave and a flexibility that allows a portion of the tube not covered by the tubular weave to collapse in the body cavity.
20. In a stent system for splitting and holding open a body cavity of the type including:
a tube made from an elastic material;
a tubular weave seating firmly on an outer surface of said tube, said weave having a filament with a diameter and;
a coating covering said tube and said weave to hold said weave on said tube, said coating having a thickness less than said filament diameter, said coating consisting essentially of a self-solidifying fluid into which said tube and said weave are dipped, whereby the stent has a structured outer surface defined by said weave, wherein said filament comprises a plurality of threads having at least one of differing separations with respect to each other and differing diameters, the improvement comprising: an anti-reflux valve formed by the tube having a length that is longer than the tubular weave and a flexibility that allows a portion of the tube not covered by the tubular weave to collapse in the body cavity.
US10/302,781 2002-11-21 2002-11-21 Anti-reflux stent Abandoned US20040102855A1 (en)

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Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040092892A1 (en) * 2002-11-01 2004-05-13 Jonathan Kagan Apparatus and methods for treatment of morbid obesity
US20050049718A1 (en) * 2002-11-01 2005-03-03 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20050060029A1 (en) * 2003-07-29 2005-03-17 Trong-Phi Le Implantable device as organ valve replacement
US20050085900A1 (en) * 2003-07-31 2005-04-21 Case Brian C. Prosthetic valve for implantation in a body vessel
US20050177181A1 (en) * 2002-11-01 2005-08-11 Jonathan Kagan Devices and methods for treating morbid obesity
US20050240279A1 (en) * 2002-11-01 2005-10-27 Jonathan Kagan Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20060015125A1 (en) * 2004-05-07 2006-01-19 Paul Swain Devices and methods for gastric surgery
US20060020247A1 (en) * 2002-11-01 2006-01-26 Jonathan Kagan Devices and methods for attaching an endolumenal gastrointestinal implant
WO2006083763A1 (en) * 2005-01-31 2006-08-10 Wilson-Cook Medical Inc. Prosthesis having a sleeve valve
US20060259113A1 (en) * 2005-04-26 2006-11-16 Alveolus, Inc. Esophageal stent and associated method
US20070010864A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Gastrointestinal implant system
US20070016306A1 (en) * 1998-08-31 2007-01-18 Wilson-Cook Medical Inc. Prosthesis having a sleeve valve
US20070100440A1 (en) * 2005-10-28 2007-05-03 Jen.Cardiotec Gmbh Device for the implantation and fixation of prosthetic valves
US20070123994A1 (en) * 2005-11-29 2007-05-31 Ethicon Endo-Surgery, Inc. Internally Placed Gastric Restriction Device
US20080046071A1 (en) * 2006-08-21 2008-02-21 Dusan Pavcnik Biomedical valve devices, support frames for use in such devices, and related methods
US20080086214A1 (en) * 1998-08-31 2008-04-10 Wilson-Cook Medical Inc. Medical device having a sleeve valve with bioactive agent
US20080167610A1 (en) * 2006-09-25 2008-07-10 Valentx, Inc. Toposcopic methods and devices for delivering a sleeve having axially compressed and elongate configurations
EP1952785A1 (en) * 2005-11-16 2008-08-06 Yingsheng Cheng A cardia stent
US20080208314A1 (en) * 2007-02-22 2008-08-28 Wilson-Cook Medical Inc. Prosthesis having a sleeve valve
US20080213652A1 (en) * 2007-02-08 2008-09-04 Karl Frederick Scheucher Battery pack safety and thermal management apparatus and method
US20090012544A1 (en) * 2007-06-08 2009-01-08 Valen Tx, Inc. Gastrointestinal bypass sleeve as an adjunct to bariatric surgery
US20090012553A1 (en) * 2007-06-08 2009-01-08 Valentx, Inc. Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US20090143760A1 (en) * 2007-11-30 2009-06-04 Jacques Van Dam Methods, Devices, Kits and Systems for Defunctionalizing the Gallbladder
US20100298632A1 (en) * 2005-01-19 2010-11-25 Gi Dynamics, Inc. Resistive Anti-Obesity Devices
US7881797B2 (en) 2006-04-25 2011-02-01 Valentx, Inc. Methods and devices for gastrointestinal stimulation
US20110054381A1 (en) * 2009-05-29 2011-03-03 Jacques Van Dam Biliary shunts, delivery systems, and methods of using the same
EP2174620B1 (en) * 2004-10-25 2012-10-17 Merit Medical Systems, Inc. Stent removal and repositioning aid
WO2013163076A1 (en) * 2012-04-27 2013-10-31 Cook Medical Technologies Llc Anti-aspiration valve
US8677874B2 (en) 2009-01-26 2014-03-25 Boston Scientific Scimed, Inc. Atraumatic stent and method and apparatus for making the same
WO2015020951A1 (en) * 2013-08-07 2015-02-12 Boston Scientific Scimed, Inc Silicone reflux valve for polymeric stents
US8956318B2 (en) 2012-05-31 2015-02-17 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9211182B2 (en) 2009-11-20 2015-12-15 E2, Llc Anti-reflux devices and methods for treating gastro-esophageal reflux disease (GERD)
EP3005978A1 (en) * 2014-10-10 2016-04-13 Rex Medical, L.P. Esophageal device for treating acid reflux
US9358095B2 (en) 2012-10-24 2016-06-07 Cook Medical Technologies Llc Anti-reflux prosthesis
US9451960B2 (en) 2012-05-31 2016-09-27 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9510934B2 (en) 2012-07-20 2016-12-06 Cook Medical Technologies Llc Implantable medical device having a sleeve
US9526605B2 (en) 2013-01-08 2016-12-27 Cook Medical Technologies Llc Multi valve anti-reflux prosthesis
US9675489B2 (en) 2012-05-31 2017-06-13 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9757264B2 (en) 2013-03-13 2017-09-12 Valentx, Inc. Devices and methods for gastrointestinal bypass
US10231819B2 (en) * 2012-04-27 2019-03-19 Cook Medical Technologies Llc Anti-aspiration prosthesis
WO2019052610A1 (en) * 2017-09-13 2019-03-21 Universitätsklinikum Hamburg-Eppendorf Implantable valve prosthesis

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040143342A1 (en) 2003-01-16 2004-07-22 Stack Richard S. Satiation pouches and methods of use
US7766973B2 (en) * 2005-01-19 2010-08-03 Gi Dynamics, Inc. Eversion resistant sleeves
EP2242455A1 (en) * 2007-12-28 2010-10-27 Boston Scientific Scimed, Inc. Prosthesis loading delivery and deployment apparatus
US9687370B2 (en) * 2008-05-09 2017-06-27 C.R. Bard, Inc. Method of loading a stent into a sheath
US20130018215A1 (en) * 2011-01-18 2013-01-17 Merit Medical Systems, Inc. Esophageal stent and methods for use of same
US8986368B2 (en) 2011-10-31 2015-03-24 Merit Medical Systems, Inc. Esophageal stent with valve
JP6179949B2 (en) 2012-01-30 2017-08-16 川澄化学工業株式会社 Biliary stent
WO2013184630A1 (en) 2012-06-05 2013-12-12 Merit Medical Systems, Inc. Esophageal stent
US20140156020A1 (en) * 2012-12-04 2014-06-05 Shanda Haley Blackmon Stent system and methods of use
WO2014138006A1 (en) 2013-03-05 2014-09-12 Merit Medical Systems, Inc. Reinforced valve
EP3062863A1 (en) 2014-04-04 2016-09-07 Gyrus ACMI, Inc. (d.b.a.Olympus Surgical Technologies America) Ureteral stent with anti-migration features
US10004617B2 (en) 2015-10-20 2018-06-26 Cook Medical Technologies Llc Woven stent device and manufacturing method

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9236A (en) * 1852-08-31 Governor for steam-engines
US4655771A (en) * 1982-04-30 1987-04-07 Shepherd Patents S.A. Prosthesis comprising an expansible or contractile tubular body
US4850999A (en) * 1980-05-24 1989-07-25 Institute Fur Textil-Und Faserforschung Of Stuttgart Flexible hollow organ
US4857069A (en) * 1984-03-01 1989-08-15 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Artificial vessel and process for preparing the same
US5123917A (en) * 1990-04-27 1992-06-23 Lee Peter Y Expandable intraluminal vascular graft
US5314473A (en) * 1989-07-20 1994-05-24 Godin Norman J Prosthesis for preventing gastric reflux into the esophagus
US5788626A (en) * 1995-11-21 1998-08-04 Schneider (Usa) Inc Method of making a stent-graft covered with expanded polytetrafluoroethylene
US5824049A (en) * 1995-06-07 1998-10-20 Med Institute, Inc. Coated implantable medical device
US5861036A (en) * 1995-03-28 1999-01-19 Biomedix S.A. Switzerland Medical prosthesis for preventing gastric reflux in the esophagus
US6162244A (en) * 1996-03-29 2000-12-19 Willy Ruesch Ag Layered stent
US6302917B1 (en) * 1998-08-31 2001-10-16 Wilson-Cook Medical Incorporated Anti-reflux esophageal prosthesis
US20020107565A1 (en) * 2000-12-01 2002-08-08 E. Skott Greenhalgh Endovascular valve
US20030212450A1 (en) * 2002-05-11 2003-11-13 Tilman Schlick Stent

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069339B (en) * 1980-02-18 1983-08-10 Keymed Medicals & Ind Equip Endo-oesophageal tube
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve
US5800339A (en) * 1989-02-09 1998-09-01 Opticon Medical Inc. Urinary control valve
DK124690D0 (en) * 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes for implantation in the body for replacement of the natural folding and catheter for use in the implantation of such a prosthesis flap
DE69719237D1 (en) * 1996-05-23 2003-04-03 Samsung Electronics Co Ltd Flexible, self-expanding stent and method for its production
JP3434160B2 (en) * 1997-01-31 2003-08-04 吉則 水本 Stent
CZ5985U1 (en) 1997-03-21 1997-06-11 Ella-Cs - Dr. Karel Volenec, Csc. Stent
US6254642B1 (en) * 1997-12-09 2001-07-03 Thomas V. Taylor Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US6117117A (en) * 1998-08-24 2000-09-12 Advanced Cardiovascular Systems, Inc. Bifurcated catheter assembly
US6264700B1 (en) * 1998-08-27 2001-07-24 Endonetics, Inc. Prosthetic gastroesophageal valve
US6746489B2 (en) * 1998-08-31 2004-06-08 Wilson-Cook Medical Incorporated Prosthesis having a sleeve valve
FR2788217A1 (en) * 1999-01-12 2000-07-13 Brice Letac Implantable prosthetic valve by catheterization, or surgically
US7018401B1 (en) * 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
EP1108400A1 (en) * 1999-12-13 2001-06-20 Biomedix S.A. Removable fixation apparatus for a prosthesis in a body vessel
US6821291B2 (en) * 2001-06-01 2004-11-23 Ams Research Corporation Retrievable stent and method of use thereof
US6845776B2 (en) * 2001-08-27 2005-01-25 Richard S. Stack Satiation devices and methods
US6790237B2 (en) * 2001-10-09 2004-09-14 Scimed Life Systems, Inc. Medical stent with a valve and related methods of manufacturing
US7211114B2 (en) * 2002-08-26 2007-05-01 The Trustees Of Columbia University In The City Of New York Endoscopic gastric bypass

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9236A (en) * 1852-08-31 Governor for steam-engines
US4850999A (en) * 1980-05-24 1989-07-25 Institute Fur Textil-Und Faserforschung Of Stuttgart Flexible hollow organ
US4954126B1 (en) * 1982-04-30 1996-05-28 Ams Med Invent S A Prosthesis comprising an expansible or contractile tubular body
US4655771A (en) * 1982-04-30 1987-04-07 Shepherd Patents S.A. Prosthesis comprising an expansible or contractile tubular body
US4954126A (en) * 1982-04-30 1990-09-04 Shepherd Patents S.A. Prosthesis comprising an expansible or contractile tubular body
US4655771B1 (en) * 1982-04-30 1996-09-10 Medinvent Ams Sa Prosthesis comprising an expansible or contractile tubular body
US4857069A (en) * 1984-03-01 1989-08-15 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Artificial vessel and process for preparing the same
US5314473A (en) * 1989-07-20 1994-05-24 Godin Norman J Prosthesis for preventing gastric reflux into the esophagus
US5123917A (en) * 1990-04-27 1992-06-23 Lee Peter Y Expandable intraluminal vascular graft
US5861036A (en) * 1995-03-28 1999-01-19 Biomedix S.A. Switzerland Medical prosthesis for preventing gastric reflux in the esophagus
US5824049A (en) * 1995-06-07 1998-10-20 Med Institute, Inc. Coated implantable medical device
US5788626A (en) * 1995-11-21 1998-08-04 Schneider (Usa) Inc Method of making a stent-graft covered with expanded polytetrafluoroethylene
US6162244A (en) * 1996-03-29 2000-12-19 Willy Ruesch Ag Layered stent
US6302917B1 (en) * 1998-08-31 2001-10-16 Wilson-Cook Medical Incorporated Anti-reflux esophageal prosthesis
US20020107565A1 (en) * 2000-12-01 2002-08-08 E. Skott Greenhalgh Endovascular valve
US20030212450A1 (en) * 2002-05-11 2003-11-13 Tilman Schlick Stent

Cited By (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080086214A1 (en) * 1998-08-31 2008-04-10 Wilson-Cook Medical Inc. Medical device having a sleeve valve with bioactive agent
US20070016306A1 (en) * 1998-08-31 2007-01-18 Wilson-Cook Medical Inc. Prosthesis having a sleeve valve
US20090149871A9 (en) * 2002-11-01 2009-06-11 Jonathan Kagan Devices and methods for treating morbid obesity
US7794447B2 (en) 2002-11-01 2010-09-14 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20050096750A1 (en) * 2002-11-01 2005-05-05 Jonathan Kagan Apparatus and methods for treatment of morbid obesity
US20050177181A1 (en) * 2002-11-01 2005-08-11 Jonathan Kagan Devices and methods for treating morbid obesity
US20050240279A1 (en) * 2002-11-01 2005-10-27 Jonathan Kagan Gastrointestinal sleeve device and methods for treatment of morbid obesity
US9839546B2 (en) 2002-11-01 2017-12-12 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US20060020247A1 (en) * 2002-11-01 2006-01-26 Jonathan Kagan Devices and methods for attaching an endolumenal gastrointestinal implant
US9561127B2 (en) 2002-11-01 2017-02-07 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US20060206064A1 (en) * 2002-11-01 2006-09-14 Jonathan Kagan Methods of adjusting therapy in a patient having an endolumenal bypass to treat obesity
US8012135B2 (en) 2002-11-01 2011-09-06 Valentx, Inc. Attachment cuff for gastrointestinal implant
US20060293742A1 (en) * 2002-11-01 2006-12-28 Mitchell Dann Cuff and sleeve system for gastrointestinal bypass
US20070010864A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Gastrointestinal implant system
US20070010794A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Devices and methods for endolumenal gastrointestinal bypass
US20070010865A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Everting gastrointestinal sleeve
US20050049718A1 (en) * 2002-11-01 2005-03-03 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US9060844B2 (en) 2002-11-01 2015-06-23 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US7220284B2 (en) 2002-11-01 2007-05-22 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US8968270B2 (en) 2002-11-01 2015-03-03 Valentx, Inc. Methods of replacing a gastrointestinal bypass sleeve for therapy adjustment
US20070198074A1 (en) * 2002-11-01 2007-08-23 Mitchell Dann Devices and methods for endolumenal gastrointestinal bypass
US8182459B2 (en) 2002-11-01 2012-05-22 Valentx, Inc. Devices and methods for endolumenal gastrointestinal bypass
US8070743B2 (en) 2002-11-01 2011-12-06 Valentx, Inc. Devices and methods for attaching an endolumenal gastrointestinal implant
US8012140B1 (en) 2002-11-01 2011-09-06 Valentx, Inc. Methods of transmural attachment in the gastrointestinal system
US20040092892A1 (en) * 2002-11-01 2004-05-13 Jonathan Kagan Apparatus and methods for treatment of morbid obesity
US7892214B2 (en) 2002-11-01 2011-02-22 Valentx, Inc. Attachment system for transmural attachment at the gastroesophageal junction
US7846138B2 (en) 2002-11-01 2010-12-07 Valentx, Inc. Cuff and sleeve system for gastrointestinal bypass
US7837669B2 (en) 2002-11-01 2010-11-23 Valentx, Inc. Devices and methods for endolumenal gastrointestinal bypass
US20050060029A1 (en) * 2003-07-29 2005-03-17 Trong-Phi Le Implantable device as organ valve replacement
US7510574B2 (en) * 2003-07-29 2009-03-31 Pfm, Produkte Fur Die Medizin Ag Implantable device as organ valve replacement
US20050085900A1 (en) * 2003-07-31 2005-04-21 Case Brian C. Prosthetic valve for implantation in a body vessel
US7686844B2 (en) 2003-07-31 2010-03-30 Cook Incorporated Prosthetic valve for implantation in a body vessel
US20100063577A1 (en) * 2003-07-31 2010-03-11 Cook Incorporated Method of implanting a prosthetic valve
US20060015125A1 (en) * 2004-05-07 2006-01-19 Paul Swain Devices and methods for gastric surgery
EP2174620B1 (en) * 2004-10-25 2012-10-17 Merit Medical Systems, Inc. Stent removal and repositioning aid
US8920358B2 (en) * 2005-01-19 2014-12-30 Gi Dynamics, Inc. Resistive anti-obesity devices
US20100298632A1 (en) * 2005-01-19 2010-11-25 Gi Dynamics, Inc. Resistive Anti-Obesity Devices
WO2006083763A1 (en) * 2005-01-31 2006-08-10 Wilson-Cook Medical Inc. Prosthesis having a sleeve valve
US20060259113A1 (en) * 2005-04-26 2006-11-16 Alveolus, Inc. Esophageal stent and associated method
US8834558B2 (en) * 2005-04-26 2014-09-16 Merit Medical Systems, Inc. Esophageal stent and associated method
USRE45790E1 (en) * 2005-10-28 2015-11-03 Jenavalve Technology Gmbh Device for the implantation and fixation of prosthetic valves
US8551160B2 (en) 2005-10-28 2013-10-08 Jenavalve Technology, Inc. Device for the implantation and fixation of prosthetic valves
US20070100440A1 (en) * 2005-10-28 2007-05-03 Jen.Cardiotec Gmbh Device for the implantation and fixation of prosthetic valves
US8092521B2 (en) * 2005-10-28 2012-01-10 Jenavalve Technology, Inc. Device for the implantation and fixation of prosthetic valves
USRE45962E1 (en) 2005-10-28 2016-04-05 Jenavalve Technology Gmbh Device for the implantation and fixation of prosthetic valves
EP1952785A1 (en) * 2005-11-16 2008-08-06 Yingsheng Cheng A cardia stent
EP1952785A4 (en) * 2005-11-16 2010-11-17 Yingsheng Cheng A cardia stent
US20070123994A1 (en) * 2005-11-29 2007-05-31 Ethicon Endo-Surgery, Inc. Internally Placed Gastric Restriction Device
US7881797B2 (en) 2006-04-25 2011-02-01 Valentx, Inc. Methods and devices for gastrointestinal stimulation
US8992598B2 (en) 2006-08-21 2015-03-31 Oregan Health And Science University Biomedical valve devices, support frames for use in such devices, and related methods
US20080046071A1 (en) * 2006-08-21 2008-02-21 Dusan Pavcnik Biomedical valve devices, support frames for use in such devices, and related methods
US8257429B2 (en) 2006-08-21 2012-09-04 Oregon Health & Science University Biomedical valve devices, support frames for use in such devices, and related methods
US20080167610A1 (en) * 2006-09-25 2008-07-10 Valentx, Inc. Toposcopic methods and devices for delivering a sleeve having axially compressed and elongate configurations
US20080167629A1 (en) * 2006-09-25 2008-07-10 Valentx, Inc. Methods for toposcopic sleeve delivery
US8118774B2 (en) 2006-09-25 2012-02-21 Valentx, Inc. Toposcopic access and delivery devices
US20080167606A1 (en) * 2006-09-25 2008-07-10 Valentx, Inc. Toposcopic access and delivery devices
US8808270B2 (en) 2006-09-25 2014-08-19 Valentx, Inc. Methods for toposcopic sleeve delivery
US20080213652A1 (en) * 2007-02-08 2008-09-04 Karl Frederick Scheucher Battery pack safety and thermal management apparatus and method
US8221505B2 (en) 2007-02-22 2012-07-17 Cook Medical Technologies Llc Prosthesis having a sleeve valve
US20080208314A1 (en) * 2007-02-22 2008-08-28 Wilson-Cook Medical Inc. Prosthesis having a sleeve valve
US20090012544A1 (en) * 2007-06-08 2009-01-08 Valen Tx, Inc. Gastrointestinal bypass sleeve as an adjunct to bariatric surgery
US8182441B2 (en) 2007-06-08 2012-05-22 Valentx, Inc. Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US20090012553A1 (en) * 2007-06-08 2009-01-08 Valentx, Inc. Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US9486219B2 (en) 2007-11-30 2016-11-08 Treus Medical, Inc. Biliary shunts, delivery systems, methods of using the same and kits therefor
US20090143759A1 (en) * 2007-11-30 2009-06-04 Jacques Van Dam Methods, Devices, Kits and Systems for Defunctionalizing the Cystic Duct
US9282968B2 (en) 2007-11-30 2016-03-15 Treus Medical, Inc. Applicator for endoscopic treatment of biliary disease
US20110071350A1 (en) * 2007-11-30 2011-03-24 Jacques Van Dam Applicator for endoscopic treatment of biliary disease
US20090143713A1 (en) * 2007-11-30 2009-06-04 Jacques Van Dam Biliary Shunts, Delivery Systems, Methods of Using the Same and Kits Therefor
US20090143760A1 (en) * 2007-11-30 2009-06-04 Jacques Van Dam Methods, Devices, Kits and Systems for Defunctionalizing the Gallbladder
US8677874B2 (en) 2009-01-26 2014-03-25 Boston Scientific Scimed, Inc. Atraumatic stent and method and apparatus for making the same
US9388517B2 (en) 2009-01-26 2016-07-12 Boston Scientific Scimed, Inc. Atraumatic stent and method and apparatus for making the same
US9901347B2 (en) 2009-05-29 2018-02-27 Terus Medical, Inc. Biliary shunts, delivery systems, and methods of using the same
US20110054381A1 (en) * 2009-05-29 2011-03-03 Jacques Van Dam Biliary shunts, delivery systems, and methods of using the same
US9211182B2 (en) 2009-11-20 2015-12-15 E2, Llc Anti-reflux devices and methods for treating gastro-esophageal reflux disease (GERD)
WO2013163076A1 (en) * 2012-04-27 2013-10-31 Cook Medical Technologies Llc Anti-aspiration valve
US10231819B2 (en) * 2012-04-27 2019-03-19 Cook Medical Technologies Llc Anti-aspiration prosthesis
US9427303B2 (en) 2012-04-27 2016-08-30 Cook Medical Technologies Llc Anti-aspiration valve
US9050168B2 (en) 2012-05-31 2015-06-09 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9681975B2 (en) 2012-05-31 2017-06-20 Valentx, Inc. Devices and methods for gastrointestinal bypass
US8956318B2 (en) 2012-05-31 2015-02-17 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9566181B2 (en) 2012-05-31 2017-02-14 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9451960B2 (en) 2012-05-31 2016-09-27 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9039649B2 (en) 2012-05-31 2015-05-26 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9173759B2 (en) 2012-05-31 2015-11-03 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9675489B2 (en) 2012-05-31 2017-06-13 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9510934B2 (en) 2012-07-20 2016-12-06 Cook Medical Technologies Llc Implantable medical device having a sleeve
US9358095B2 (en) 2012-10-24 2016-06-07 Cook Medical Technologies Llc Anti-reflux prosthesis
US9526605B2 (en) 2013-01-08 2016-12-27 Cook Medical Technologies Llc Multi valve anti-reflux prosthesis
US9757264B2 (en) 2013-03-13 2017-09-12 Valentx, Inc. Devices and methods for gastrointestinal bypass
CN105658175A (en) * 2013-08-07 2016-06-08 波士顿科学国际有限公司 Silicone reflux valve for polymeric stents
US20150045908A1 (en) * 2013-08-07 2015-02-12 Boston Scientific Scimed, Inc. Silicone reflux valve for polymeric stents
WO2015020951A1 (en) * 2013-08-07 2015-02-12 Boston Scientific Scimed, Inc Silicone reflux valve for polymeric stents
US9901436B2 (en) 2014-10-10 2018-02-27 Rex Medical, L.P. Esophageal sleeve
EP3005978A1 (en) * 2014-10-10 2016-04-13 Rex Medical, L.P. Esophageal device for treating acid reflux
WO2019052610A1 (en) * 2017-09-13 2019-03-21 Universitätsklinikum Hamburg-Eppendorf Implantable valve prosthesis

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US20070112437A1 (en) 2007-05-17
WO2004047686A1 (en) 2004-06-10

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