UA75026C2 - Tripeptide inhibitors of hepatitis c virus, a method for producing thereof and a pharmaceutical composition - Google Patents
Tripeptide inhibitors of hepatitis c virus, a method for producing thereof and a pharmaceutical composition Download PDFInfo
- Publication number
- UA75026C2 UA75026C2 UA2001031603A UA2001031603A UA75026C2 UA 75026 C2 UA75026 C2 UA 75026C2 UA 2001031603 A UA2001031603 A UA 2001031603A UA 2001031603 A UA2001031603 A UA 2001031603A UA 75026 C2 UA75026 C2 UA 75026C2
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- butyl
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 15
- 241000711549 Hepacivirus C Species 0.000 title claims description 13
- 239000003112 inhibitor Substances 0.000 title description 24
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 225
- 125000003368 amide group Chemical group 0.000 claims abstract description 161
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 157
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 128
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- 229910052736 halogen Inorganic materials 0.000 claims abstract description 70
- 125000003118 aryl group Chemical group 0.000 claims abstract description 30
- 150000002148 esters Chemical class 0.000 claims abstract description 30
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 23
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract description 19
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 18
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 18
- 150000003839 salts Chemical class 0.000 claims abstract description 16
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- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 14
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- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 claims abstract description 10
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
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PCT/CA1999/000736 WO2000009543A2 (en) | 1998-08-10 | 1999-08-09 | Hepatitis c inhibitor tri-peptides |
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UA2001031603A UA75026C2 (en) | 1998-08-10 | 1999-09-08 | Tripeptide inhibitors of hepatitis c virus, a method for producing thereof and a pharmaceutical composition |
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