NO324227B1 - Cyclopropyl-kondenserte pyrrolidin-baserte forbindelser, farmasoytiske blandinger og kombinasjoner inneholdende slike samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdommer - Google Patents

Cyclopropyl-kondenserte pyrrolidin-baserte forbindelser, farmasoytiske blandinger og kombinasjoner inneholdende slike samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdommer

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Publication number
NO324227B1
NO324227B1 NO20024295A NO20024295A NO324227B1 NO 324227 B1 NO324227 B1 NO 324227B1 NO 20024295 A NO20024295 A NO 20024295A NO 20024295 A NO20024295 A NO 20024295A NO 324227 B1 NO324227 B1 NO 324227B1
Authority
NO
Norway
Prior art keywords
medicaments
cyclopropyl
diseases
manufacture
treatment
Prior art date
Application number
NO20024295A
Other languages
English (en)
Norwegian (no)
Other versions
NO20024295L (no
NO20024295D0 (no
Inventor
David R Magnin
Jeffrey A Robl
Richard B Sulsky
David J Augeri
Lawrence G Hamann
David A Betenbenner
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22693638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO324227(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20024295D0 publication Critical patent/NO20024295D0/no
Publication of NO20024295L publication Critical patent/NO20024295L/no
Publication of NO324227B1 publication Critical patent/NO324227B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A—HUMAN NECESSITIES
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
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  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
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  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
NO20024295A 2000-03-10 2002-09-09 Cyclopropyl-kondenserte pyrrolidin-baserte forbindelser, farmasoytiske blandinger og kombinasjoner inneholdende slike samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdommer NO324227B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18855500P 2000-03-10 2000-03-10
PCT/US2001/007151 WO2001068603A2 (en) 2000-03-10 2001-03-05 Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl iv, processes for their preparation, and their use

Publications (3)

Publication Number Publication Date
NO20024295D0 NO20024295D0 (no) 2002-09-09
NO20024295L NO20024295L (no) 2002-11-06
NO324227B1 true NO324227B1 (no) 2007-09-10

Family

ID=22693638

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20024295A NO324227B1 (no) 2000-03-10 2002-09-09 Cyclopropyl-kondenserte pyrrolidin-baserte forbindelser, farmasoytiske blandinger og kombinasjoner inneholdende slike samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdommer
NO2010006C NO2010006I2 (no) 2000-03-10 2010-03-16 Saksagliptin og farmasøytisk akseptable salter derav, inklusive saksagliptin hydroklorid
NO2012009C NO2012009I2 (no) 2000-03-10 2012-05-21 Kombinasjonsprodukt av saxaglipin og metformin og farmasøytisk akseptable salter derav, herunder HCIsaltene av saxaglipin og metformin

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO2010006C NO2010006I2 (no) 2000-03-10 2010-03-16 Saksagliptin og farmasøytisk akseptable salter derav, inklusive saksagliptin hydroklorid
NO2012009C NO2012009I2 (no) 2000-03-10 2012-05-21 Kombinasjonsprodukt av saxaglipin og metformin og farmasøytisk akseptable salter derav, herunder HCIsaltene av saxaglipin og metformin

Country Status (37)

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US (2) US6395767B2 (cg-RX-API-DMAC10.html)
EP (4) EP2995615B1 (cg-RX-API-DMAC10.html)
JP (5) JP4460205B2 (cg-RX-API-DMAC10.html)
KR (2) KR100758407B1 (cg-RX-API-DMAC10.html)
CN (2) CN1698601A (cg-RX-API-DMAC10.html)
AR (1) AR027634A1 (cg-RX-API-DMAC10.html)
AT (1) ATE396176T1 (cg-RX-API-DMAC10.html)
AU (2) AU4546601A (cg-RX-API-DMAC10.html)
BE (2) BE2010C008I2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0109115B8 (cg-RX-API-DMAC10.html)
CA (1) CA2402894C (cg-RX-API-DMAC10.html)
CO (1) CO5280198A1 (cg-RX-API-DMAC10.html)
CY (3) CY1108273T1 (cg-RX-API-DMAC10.html)
CZ (3) CZ307821B6 (cg-RX-API-DMAC10.html)
DE (3) DE122010000008I1 (cg-RX-API-DMAC10.html)
DK (1) DK1261586T3 (cg-RX-API-DMAC10.html)
EG (1) EG25854A (cg-RX-API-DMAC10.html)
ES (4) ES2768961T3 (cg-RX-API-DMAC10.html)
FR (2) FR10C0010I2 (cg-RX-API-DMAC10.html)
HK (1) HK1049330B (cg-RX-API-DMAC10.html)
HU (5) HU230380B1 (cg-RX-API-DMAC10.html)
IL (4) IL151372A0 (cg-RX-API-DMAC10.html)
LU (2) LU91650I2 (cg-RX-API-DMAC10.html)
MX (1) MXPA02008837A (cg-RX-API-DMAC10.html)
MY (1) MY124512A (cg-RX-API-DMAC10.html)
NL (1) NL300436I1 (cg-RX-API-DMAC10.html)
NO (3) NO324227B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ520821A (cg-RX-API-DMAC10.html)
PE (1) PE20020771A1 (cg-RX-API-DMAC10.html)
PL (1) PL207041B1 (cg-RX-API-DMAC10.html)
PT (1) PT1261586E (cg-RX-API-DMAC10.html)
RU (1) RU2286986C2 (cg-RX-API-DMAC10.html)
SG (1) SG152030A1 (cg-RX-API-DMAC10.html)
TW (2) TWI258468B (cg-RX-API-DMAC10.html)
UY (2) UY26613A1 (cg-RX-API-DMAC10.html)
WO (1) WO2001068603A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200206816B (cg-RX-API-DMAC10.html)

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