JP5667440B2 - グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 - Google Patents

グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 Download PDF

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JP5667440B2
JP5667440B2 JP2010503514A JP2010503514A JP5667440B2 JP 5667440 B2 JP5667440 B2 JP 5667440B2 JP 2010503514 A JP2010503514 A JP 2010503514A JP 2010503514 A JP2010503514 A JP 2010503514A JP 5667440 B2 JP5667440 B2 JP 5667440B2
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alkyl
methyl
phenyl
imidazol
thiourea
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JP2010524897A (ja
JP2010524897A5 (en:Method
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ブクフホルズ ミルコ
ブクフホルズ ミルコ
ジェイ．ニエストロジェ アンドレ
ジェイ．ニエストロジェ アンドレ
ヘイセル ウルリクフ
ヘイセル ウルリクフ
ソムメル ロベルト
ソムメル ロベルト
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プロビオドルグ エージー
プロビオドルグ エージー
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heart & Thoracic Surgery (AREA)
JP2010503514A 2007-04-18 2008-04-18 グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 Expired - Fee Related JP5667440B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91253107P 2007-04-18 2007-04-18
US60/912,531 2007-04-18
PCT/EP2008/054715 WO2008128985A1 (en) 2007-04-18 2008-04-18 Thiourea derivatives as glutaminyl cyclase inhibitors

Related Child Applications (1)

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JP2014179194A Division JP5891278B2 (ja) 2007-04-18 2014-09-03 グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体

Publications (3)

Publication Number Publication Date
JP2010524897A JP2010524897A (ja) 2010-07-22
JP2010524897A5 JP2010524897A5 (en:Method) 2011-06-02
JP5667440B2 true JP5667440B2 (ja) 2015-02-12

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JP2010503514A Expired - Fee Related JP5667440B2 (ja) 2007-04-18 2008-04-18 グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
JP2014179194A Expired - Fee Related JP5891278B2 (ja) 2007-04-18 2014-09-03 グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体

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Country Status (6)

Country Link
US (1) US9656991B2 (en:Method)
EP (2) EP2142514B1 (en:Method)
JP (2) JP5667440B2 (en:Method)
DK (1) DK2142514T3 (en:Method)
ES (1) ES2533484T3 (en:Method)
WO (1) WO2008128985A1 (en:Method)

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US8338120B2 (en) * 2003-05-05 2012-12-25 Probiodrug Ag Method of treating inflammation with glutaminyl cyclase inhibitors
US7732162B2 (en) * 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
EP2142536B1 (en) * 2007-04-20 2015-10-21 Probiodrug AG Aminopyrimidine derivatives as glutaminyl cyclase inhibitors
JP2011501652A (ja) * 2007-09-12 2011-01-13 プロビオドルグ エージー トランスジェニックマウス
EP2238252B1 (en) * 2008-01-14 2013-07-31 Probiodrug AG Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene
AU2009273387B9 (en) 2008-07-21 2015-06-11 Vivoryon Therapeutics N.V. Diagnostic antibody assay
NZ598685A (en) 2009-09-11 2013-05-31 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
US20110152341A1 (en) 2009-12-22 2011-06-23 Probiodrug Ag Cleavage of b-amyloid precursor protein
US20110212853A1 (en) 2010-02-18 2011-09-01 Probiodrug Ag Novel diagnostic method
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
SG192805A1 (en) 2011-03-16 2013-09-30 Probiodrug Ag Diagnostic antibody assay
KR101450960B1 (ko) 2011-05-23 2014-10-22 서울대학교산학협력단 ＲＯＲα의 활성자로서의 신규한 ｔｈｉｏｕｒｅａ 유도체 및 이를 함유하는 약학적 조성물
KR20210149905A (ko) 2013-01-22 2021-12-09 비스타젠 쎄라퓨틱스, 인크. L-4-클로로키뉴레닌의 투여형 및 치료적 용도
JP2018501482A (ja) 2014-12-19 2018-01-18 プロビオドルグ エージー ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法
KR101909089B1 (ko) * 2016-11-30 2018-10-18 (주) 메디프론디비티 페닐티오우레아 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 글루타미닐 사이클레이즈 활성 관련 질환의 예방 또는 치료용 약학적 조성물
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
TWI715156B (zh) 2018-08-31 2021-01-01 財團法人國家衛生研究院 苯并咪唑化合物及其用於治療阿茲海默症或亨丁頓氏症之用途
KR102405760B1 (ko) * 2018-08-31 2022-06-07 내셔날 헬스 리서치 인스티튜트 벤즈이미다졸 화합물 및 알츠하이머 질환 또는 헌팅톤병을 치료하기 위한 그의 용도
KR102230832B1 (ko) * 2019-06-17 2021-03-24 (주) 메디프론디비티 N-치환된 티오우레아 또는 우레아 유도체 및 이를 유효성분으로 함유하는 글루타미닐 사이클레이즈 활성 관련 질환의 예방 또는 치료용 약학적 조성물
CN116768770A (zh) * 2023-06-06 2023-09-19 上海交通大学医学院 二芳基硫脲类化合物及其应用

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US20080286231A1 (en) 2008-11-20
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