PE20050555A1 - Compuestos con puente n-arilsulfonilpiperidina como inhibidores de la gamma-secretasa - Google Patents

Compuestos con puente n-arilsulfonilpiperidina como inhibidores de la gamma-secretasa

Info

Publication number
PE20050555A1
PE20050555A1 PE2004000484A PE2004000484A PE20050555A1 PE 20050555 A1 PE20050555 A1 PE 20050555A1 PE 2004000484 A PE2004000484 A PE 2004000484A PE 2004000484 A PE2004000484 A PE 2004000484A PE 20050555 A1 PE20050555 A1 PE 20050555A1
Authority
PE
Peru
Prior art keywords
cycloalkyl
nr6r7
heteroaryl
alkyl
halogen
Prior art date
Application number
PE2004000484A
Other languages
English (en)
Inventor
Hubert Josien
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20050555A1 publication Critical patent/PE20050555A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A COMPUESTOS QUE CONTIENEN UN PUENTE DERIVADO DE N-ARILSULFONILPIPERIDINAS DE FORMULA (I), EN DONDE Ar ES ARILO O HETEROARILO; X ES O, NH O NR6; m ES DE 0 A 3, SIEMPRE QUE CUANDO SEA 0, NO HAYA DOBLE ENLACE, Y SI m > 0, PUEDE HABER DOBLE O TRIPLE ENLACE; n ES DE 0 A 3; R1 ES DE 1 A 3 SUSTITUYENTES DE HALOGENO, H, CICLOALQUILO, HALOGENO, -CF3, -NR6R7, CN, ENTRE OTROS; R2 ES H, ALQUILO, CICLOALQUILO, ALQUILEN-CICLOALQUILO, ENTRE OTROS; R3 ES H, HALOGENO, CICLOALQUILO, -OH, -OCF3, ENTRE OTROS; R4 ES H, ALQUILO, CICLOALQUILO, ARILO O HETEROARILO O R3 Y R4 JUNTOS FORMAN UN ANILLO DE 3 A 6 MIEMBROS; R5 ES -NR6R7, -N(R6)-ALQUILEN-NR6R7, ALQUILO, HETEROARILO, ENTRE OTROS O BIEN UN RADICAL PIRROLIDINIL, PIPERIDINIL, MORFOLINIL, PIPERAZINIL, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON (R8)r, R9, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(N-2-HIDROXIETIL)PIPERAZIN-1-CARBOXIL]-9- [4-CLORO-BENZENSULFONIL]-AZABICICLO-[3,3,1]-NONATO, ENTRE OTROS. ESTOS COMPUESTOS SON INHIBIDORES DE LA GAMMA SECRETASA, POR LO INHIBEN LA DEPOSICION DE LA PROTEINA BETA-AMILOIDE Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS COMO EL ALZHEIMER
PE2004000484A 2003-05-13 2004-05-11 Compuestos con puente n-arilsulfonilpiperidina como inhibidores de la gamma-secretasa PE20050555A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47014603P 2003-05-13 2003-05-13

Publications (1)

Publication Number Publication Date
PE20050555A1 true PE20050555A1 (es) 2005-07-19

Family

ID=33452372

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000484A PE20050555A1 (es) 2003-05-13 2004-05-11 Compuestos con puente n-arilsulfonilpiperidina como inhibidores de la gamma-secretasa

Country Status (14)

Country Link
US (1) US7368457B2 (es)
EP (1) EP1641801B9 (es)
JP (1) JP2007501859A (es)
CN (1) CN1820010A (es)
AR (1) AR044294A1 (es)
AT (1) ATE401328T1 (es)
CA (1) CA2525124A1 (es)
CL (1) CL2004001011A1 (es)
DE (1) DE602004015110D1 (es)
ES (1) ES2308206T3 (es)
MX (1) MXPA05012268A (es)
PE (1) PE20050555A1 (es)
TW (1) TW200510405A (es)
WO (1) WO2004101562A2 (es)

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AU2002217999A1 (en) 2000-11-01 2002-05-15 Cor Therapeutics, Inc. Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
AR050994A1 (es) * 2004-06-30 2006-12-13 Schering Corp N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas, y composicion farmaceutica en base al compuesto
CN101426860A (zh) * 2005-08-19 2009-05-06 伊兰医药品股份有限公司 γ-分泌酶的桥连N-环磺酰氨基抑制剂
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
CA2679446C (en) 2007-03-01 2016-05-17 Probiodrug Ag New use of glutaminyl cyclase inhibitors
DK2142514T3 (da) 2007-04-18 2015-03-23 Probiodrug Ag Thioureaderivater som glutaminylcyclase-inhibitorer
AR076936A1 (es) * 2009-06-02 2011-07-20 Vitae Pharmaceuticals Inc Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1
WO2011029920A1 (en) 2009-09-11 2011-03-17 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
BR112012022478B1 (pt) 2010-03-10 2021-09-21 Probiodrug Ag Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
KR20190007106A (ko) 2011-12-21 2019-01-21 노비라 테라퓨틱스, 인코포레이티드 B형 간염의 항바이러스성 제제
BR112015004205B1 (pt) 2012-08-28 2022-02-01 Janssen Sciences Ireland Uc Sulfamoil-arilamidas, seu uso das mesmas como medicamentos para o tratamento da hepatite b, composição farmacêutica que as compreende e produto
SI2961732T1 (sl) 2013-02-28 2017-07-31 Janssen Sciences Ireland Uc Sulfamoil-arilamidi in njihova uporaba kot zdravila za zdravljenje hepatitisa B
EP2981536B1 (en) 2013-04-03 2017-06-14 Janssen Sciences Ireland UC N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
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ES2695182T3 (es) 2013-05-17 2019-01-02 Janssen Sciences Ireland Uc Derivados de sulfamoil tiofenamida y su uso como medicamentos para tratar la hepatitis B
DK3024819T3 (en) 2013-07-25 2018-06-06 Janssen Sciences Ireland Uc GLYOXAMIDE-SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B
WO2015059212A1 (en) 2013-10-23 2015-04-30 Janssen R&D Ireland Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US20150216938A1 (en) 2014-02-05 2015-08-06 Novira Therapeutics Inc. Combination therapy for treatment of hbv infections
EA035848B1 (ru) 2014-02-06 2020-08-20 Янссен Сайенсиз Айрлэнд Юси Производные сульфамоилпирроламида и их применение в качестве медикаментов для лечения гепатита b
WO2015131773A1 (zh) 2014-03-06 2015-09-11 上海海雁医药科技有限公司 作为食欲素受体拮抗剂的哌啶衍生物
EA201792069A1 (ru) 2015-03-19 2018-04-30 Новира Терапьютикс, Инк. Производные азокана и азонана и способы лечения инфекций гепатита в
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
CA3000197A1 (en) 2015-09-29 2017-04-06 Novira Therapeutics, Inc. Crystalline forms of a hepatitis b antiviral agent
JP2019511542A (ja) 2016-04-15 2019-04-25 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー カプシド集合阻害剤を含む組み合わせ及び方法
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase
MX2020009531A (es) 2018-03-14 2020-10-05 Janssen Sciences Ireland Unlimited Co Regimen posologico del modulador del ensamblaje de la capside.
AU2020223865A1 (en) 2019-02-22 2021-07-15 Janssen Sciences Ireland Unlimited Company Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
JP2022532526A (ja) 2019-05-06 2022-07-15 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Ｈｂｖ感染又はｈｂｖ誘導性疾患の処置において有用なアミド誘導体

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Also Published As

Publication number Publication date
MXPA05012268A (es) 2006-02-10
EP1641801B1 (en) 2008-07-16
US7368457B2 (en) 2008-05-06
TW200510405A (en) 2005-03-16
ATE401328T1 (de) 2008-08-15
DE602004015110D1 (de) 2008-08-28
WO2004101562A3 (en) 2005-02-10
CL2004001011A1 (es) 2005-03-18
WO2004101562A2 (en) 2004-11-25
CN1820010A (zh) 2006-08-16
US20040229902A1 (en) 2004-11-18
AR044294A1 (es) 2005-09-07
CA2525124A1 (en) 2004-11-25
EP1641801B9 (en) 2009-02-25
ES2308206T3 (es) 2008-12-01
EP1641801A2 (en) 2006-04-05
JP2007501859A (ja) 2007-02-01

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