PE20061444A1 - Anticuerpo anti-mcp-1, composiciones, metodos y usos - Google Patents
Anticuerpo anti-mcp-1, composiciones, metodos y usosInfo
- Publication number
- PE20061444A1 PE20061444A1 PE2006000524A PE2006000524A PE20061444A1 PE 20061444 A1 PE20061444 A1 PE 20061444A1 PE 2006000524 A PE2006000524 A PE 2006000524A PE 2006000524 A PE2006000524 A PE 2006000524A PE 20061444 A1 PE20061444 A1 PE 20061444A1
- Authority
- PE
- Peru
- Prior art keywords
- mcp
- antibody
- sequences
- seq
- nos
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
SE REFIERE A ANTICUERPOS ANTI-MCP-1 AISLADOS DE MAMIFERO QUE COMPRENDE POR LO MENOS UNA REGION VARIABLE DE CADENA PESADA Y POR LO MENOS UNA REGION VARIABLE DE CADENA LIVIANA DONDE DICHO ANTICUERPO COMPRENDE LA TOTALIDAD DE LAS SECUENCIAS DE AMINOACIDOS DE LA REGION DETERMINANTE DE COMPLEMENTARIEDAD (CDR) DE CADENA PESADA Y DE CADENA LIVIANA, DE LAS SECUENCIAS SEQ ID NOS: 42-45 Y 51-57 O LAS SECUENCIAS SEQ ID NOS: 48 Y 49. DICHO ANTICUERPO MCP-1, MODULA POR LO MENOS LA ACTIVIDAD DE POR LO MENOS UN POLIPEPTIDO MCP-1 (PROTEINA QUIMIOATRACTIVA MONOCICLICA HUMANA O CCL-2). TAMBIEN SE REFIERE A ACIDOS NUCLEICOS QUE CODIFICAN POR LO MENOS UN ANTICUERPO ANTI-MCP-1, MCP-1, VECTORES, CELULAS HUESPED, ANIMALES O PLANTAS TRANSGENICAS. UNA COMPOSICON FARMACEUTICA Y UN DISPOSITIVO TERAPEUTICO
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EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
WO2009006359A2 (en) * | 2007-06-29 | 2009-01-08 | Centocor, Inc. | Anti- mcp-1 antibodies, compositions, methods and uses |
DK2328930T3 (da) | 2008-08-20 | 2015-03-30 | Probiodrug Ag | Antistoffer rettet mod pyroglutamat-monocyt-kemoattraktant-protein-1 (mcp-1N1pE) |
CA2772488C (en) | 2009-09-11 | 2018-04-17 | Probiodrug Ag | Heterocyclic derivatives as inhibitors of glutaminyl cyclase |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
US8269019B2 (en) | 2010-03-10 | 2012-09-18 | Probiodrug Ag | Inhibitors |
EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
AU2013266340A1 (en) * | 2012-05-22 | 2014-12-04 | Shire Human Genetic Therapies, Inc. | Anti-CCL2 antibodies for treatment of scleroderma |
EP2727944A1 (en) * | 2012-10-30 | 2014-05-07 | Universitätsklinikum Regensburg | Depletion of CCR2-positive monocytes for the treatment of inflammatory conditions in the gastrointestinal system |
EP3108013B1 (en) | 2014-02-18 | 2019-09-18 | Dignity Health | Lkb1 related diagnostics and treatments of cancer |
EP3050574B1 (en) | 2015-01-28 | 2019-10-09 | Universite De Bordeaux | Use of plerixafor for treating and/or preventing acute exacerbations of chronic obstructive pulmonary disease |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
US20220204608A1 (en) | 2019-04-17 | 2022-06-30 | Hiroshima University | Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination |
CN114867532A (zh) * | 2019-12-18 | 2022-08-05 | 豪夫迈·罗氏有限公司 | 双特异性抗ccl2抗体 |
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CN114990073A (zh) * | 2022-05-27 | 2022-09-02 | 河南农业大学 | 一种抗猪ccl2蛋白的单克隆抗体及其制备方法和应用 |
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CN101511869A (zh) | 2009-08-19 |
NO20076563L (no) | 2008-02-05 |
ES2438193T3 (es) | 2014-01-16 |
JP4975020B2 (ja) | 2012-07-11 |
EP1888114A4 (en) | 2010-02-24 |
ZA200711073B (en) | 2009-09-30 |
CA2609349C (en) | 2012-10-30 |
EA200702532A1 (ru) | 2008-06-30 |
CN101511869B (zh) | 2012-12-12 |
WO2006125202A3 (en) | 2009-05-07 |
EP1888114B1 (en) | 2013-09-18 |
EP1888114A2 (en) | 2008-02-20 |
AU2010202813B2 (en) | 2011-11-03 |
IL187459A0 (en) | 2008-03-20 |
AU2006247034A1 (en) | 2006-11-23 |
AR053470A1 (es) | 2007-05-09 |
AU2006247034B2 (en) | 2010-12-02 |
WO2006125202A2 (en) | 2006-11-23 |
AU2010202813A1 (en) | 2010-07-22 |
EA014229B1 (ru) | 2010-10-29 |
PE20110071A1 (es) | 2011-01-31 |
JP2008546374A (ja) | 2008-12-25 |
KR20080012968A (ko) | 2008-02-12 |
KR100977823B1 (ko) | 2010-08-25 |
CR9606A (es) | 2010-08-18 |
TW200716174A (en) | 2007-05-01 |
CA2609349A1 (en) | 2006-11-23 |
BRPI0613164A2 (pt) | 2010-12-21 |
PA8675801A1 (es) | 2006-12-07 |
MX2007014610A (es) | 2008-04-14 |
NZ563516A (en) | 2011-04-29 |
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