|
JPS5144499B1
(OSRAM)
|
1970-08-29 |
1976-11-29 |
|
|
|
JPS5334319B2
(OSRAM)
|
1971-12-28 |
1978-09-20 |
|
|
|
JPS5717624B2
(OSRAM)
|
1974-04-17 |
1982-04-12 |
|
|
|
JPS59878B2
(ja)
|
1975-09-04 |
1984-01-09 |
松下電工株式会社 |
感知器
|
|
US4208479A
(en)
|
1977-07-14 |
1980-06-17 |
Syva Company |
Label modified immunoassays
|
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
US4444878A
(en)
|
1981-12-21 |
1984-04-24 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
|
JPS58201994A
(ja)
|
1982-05-21 |
1983-11-25 |
Hideaki Hagiwara |
抗原特異的ヒト免疫グロブリンの生産方法
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
JPH0234615Y2
(OSRAM)
|
1986-08-08 |
1990-09-18 |
|
|
|
JPH06104071B2
(ja)
|
1986-08-24 |
1994-12-21 |
財団法人化学及血清療法研究所 |
第▲ix▼因子コンホメ−シヨン特異性モノクロ−ナル抗体
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
US5670373A
(en)
*
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
|
US5322678A
(en)
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
|
US6010902A
(en)
|
1988-04-04 |
2000-01-04 |
Bristol-Meyers Squibb Company |
Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
|
|
US5126250A
(en)
|
1988-09-28 |
1992-06-30 |
Eli Lilly And Company |
Method for the reduction of heterogeneity of monoclonal antibodies
|
|
IL89491A0
(en)
|
1988-11-17 |
1989-09-10 |
Hybritech Inc |
Bifunctional chimeric antibodies
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
JPH0341033A
(ja)
|
1989-07-07 |
1991-02-21 |
Kyowa Hakko Kogyo Co Ltd |
安定なモチリン類含有製剤
|
|
GB8916400D0
(en)
|
1989-07-18 |
1989-09-06 |
Dynal As |
Modified igg3
|
|
WO1991008770A1
(en)
|
1989-12-11 |
1991-06-27 |
Immunomedics, Inc. |
Method for antibody targeting of diagnostic or therapeutic agents
|
|
US5859205A
(en)
*
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
TW212184B
(OSRAM)
|
1990-04-02 |
1993-09-01 |
Takeda Pharm Industry Co Ltd |
|
|
JPH05184383A
(ja)
|
1990-06-19 |
1993-07-27 |
Dainabotsuto Kk |
二重特異性抗体
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
ES2139598T3
(es)
|
1990-07-10 |
2000-02-16 |
Medical Res Council |
Procedimientos para la produccion de miembros de parejas de union especifica.
|
|
JPH05199894A
(ja)
|
1990-08-20 |
1993-08-10 |
Takeda Chem Ind Ltd |
二重特異性抗体および抗体含有薬剤
|
|
JP2938569B2
(ja)
|
1990-08-29 |
1999-08-23 |
ジェンファーム インターナショナル,インコーポレイティド |
異種免疫グロブリンを作る方法及びトランスジェニックマウス
|
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5795965A
(en)
|
1991-04-25 |
1998-08-18 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human to human interleukin-6 receptor
|
|
JPH05304992A
(ja)
|
1991-06-20 |
1993-11-19 |
Takeda Chem Ind Ltd |
ハイブリッド・モノクローナル抗体および抗体含有薬剤
|
|
US5637481A
(en)
*
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
|
US6136310A
(en)
|
1991-07-25 |
2000-10-24 |
Idec Pharmaceuticals Corporation |
Recombinant anti-CD4 antibodies for human therapy
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
US6027725A
(en)
|
1991-11-25 |
2000-02-22 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
EP1136556B1
(en)
|
1991-11-25 |
2005-06-08 |
Enzon, Inc. |
Method of producing multivalent antigen-binding proteins
|
|
WO1993011236A1
(en)
|
1991-12-02 |
1993-06-10 |
Medical Research Council |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
JPH05203652A
(ja)
|
1992-01-28 |
1993-08-10 |
Fuji Photo Film Co Ltd |
抗体酵素免疫分析法
|
|
JPH05213775A
(ja)
|
1992-02-05 |
1993-08-24 |
Otsuka Pharmaceut Co Ltd |
Bfa抗体
|
|
US6749853B1
(en)
|
1992-03-05 |
2004-06-15 |
Board Of Regents, The University Of Texas System |
Combined methods and compositions for coagulation and tumor treatment
|
|
JP3507073B2
(ja)
|
1992-03-24 |
2004-03-15 |
ケンブリッジ アンティボディー テクノロジー リミティド |
特異的結合対の成員の製造方法
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
US5744446A
(en)
|
1992-04-07 |
1998-04-28 |
Emory University |
Hybrid human/animal factor VIII
|
|
SG48760A1
(en)
|
1992-07-24 |
2003-03-18 |
Abgenix Inc |
Generation of xenogenetic antibodies
|
|
ZA936260B
(en)
|
1992-09-09 |
1994-03-18 |
Smithkline Beecham Corp |
Novel antibodies for conferring passive immunity against infection by a pathogen in man
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US5837821A
(en)
*
|
1992-11-04 |
1998-11-17 |
City Of Hope |
Antibody construct
|
|
EP0672142B1
(en)
|
1992-12-04 |
2001-02-28 |
Medical Research Council |
Multivalent and multispecific binding proteins, their manufacture and use
|
|
SG55079A1
(en)
|
1992-12-11 |
1998-12-21 |
Dow Chemical Co |
Multivalent single chain antibodies
|
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
|
EP0660937A1
(en)
|
1993-07-01 |
1995-07-05 |
Dade International Inc. |
Process for the preparation of factor x depleted plasma
|
|
UA40577C2
(uk)
|
1993-08-02 |
2001-08-15 |
Мерк Патент Гмбх |
Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин
|
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
|
US6214613B1
(en)
|
1993-12-03 |
2001-04-10 |
Ashai Kasei Kogyo Kabushiki Kaisha |
Expression screening vector
|
|
EP0731842A1
(en)
|
1993-12-03 |
1996-09-18 |
Medical Research Council |
Recombinant binding proteins and peptides
|
|
DE122009000068I2
(de)
|
1994-06-03 |
2011-06-16 |
Ascenion Gmbh |
Verfahren zur Herstellung von heterologen bispezifischen Antikörpern
|
|
US5945311A
(en)
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
|
US8017121B2
(en)
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
JP4361133B2
(ja)
|
1994-07-11 |
2009-11-11 |
ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム |
血管系の特異的凝固のための方法および組成物
|
|
DE69535243T2
(de)
|
1994-07-13 |
2007-05-10 |
Chugai Seiyaku K.K. |
Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper
|
|
DE69534530T2
(de)
|
1994-08-12 |
2006-07-06 |
Immunomedics, Inc. |
Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
|
|
US6451523B1
(en)
*
|
1994-09-14 |
2002-09-17 |
Interneuron Pharmaceuticals, Inc. |
Detection of a leptin receptor variant and methods for regulating obesity
|
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
|
EP0783893B1
(en)
|
1994-10-07 |
2012-04-04 |
Chugai Seiyaku Kabushiki Kaisha |
Inhibition of abnormal growth of synovial cells using il-6 antagonist as active ingredient
|
|
CA2203182C
(en)
|
1994-10-21 |
2009-11-24 |
Asao Katsume |
Remedy for diseases caused by il-6 production
|
|
WO1996016673A1
(en)
|
1994-12-02 |
1996-06-06 |
Chiron Corporation |
Method of promoting an immune response with a bispecific antibody
|
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
|
DE69611288T2
(de)
|
1995-02-28 |
2001-07-19 |
The Procter & Gamble Company, Cincinnati |
Herstellung eines kohlensäurefreien getränks mit verbesserter mikrobieller stabilität
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
DE69637481T2
(de)
|
1995-04-27 |
2009-04-09 |
Amgen Fremont Inc. |
Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
JP4212111B2
(ja)
|
1995-05-03 |
2009-01-21 |
バイオエンハンスメンツ リミテッド |
結合能力が光開裂性分子により可逆的に阻害される二重特異性抗体
|
|
JP3946256B2
(ja)
|
1995-09-11 |
2007-07-18 |
協和醗酵工業株式会社 |
ヒトインターロイキン5受容体α鎖に対する抗体
|
|
CA2241564C
(en)
|
1996-01-08 |
2013-09-03 |
Genentech, Inc. |
Wsx receptor and ligands
|
|
MA24512A1
(fr)
|
1996-01-17 |
1998-12-31 |
Univ Vermont And State Agrienl |
Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
|
|
FR2745008A1
(fr)
*
|
1996-02-20 |
1997-08-22 |
Ass Pour Le Dev De La Rech En |
Recepteur nucleaire de glucocorticoides modifie, fragments d'adn codant pour ledit recepteur et procedes dans lesquels ils sont mis en oeuvre
|
|
US5945231A
(en)
*
|
1996-03-26 |
1999-08-31 |
California Institute Of Technology |
Direct liquid-feed fuel cell with membrane electrolyte and manufacturing thereof
|
|
JP3032287U
(ja)
|
1996-06-10 |
1996-12-17 |
幸喜 高橋 |
人 形
|
|
US20020147326A1
(en)
|
1996-06-14 |
2002-10-10 |
Smithkline Beecham Corporation |
Hexameric fusion proteins and uses therefor
|
|
US6211150B1
(en)
|
1996-07-19 |
2001-04-03 |
Amgen Inc. |
Analogs of cationic proteins
|
|
US6903194B1
(en)
|
1996-09-26 |
2005-06-07 |
Chungai Seiyaku Kabushiki Kaisha |
Antibody against human parathormone related peptides
|
|
JPH10165184A
(ja)
|
1996-12-16 |
1998-06-23 |
Tosoh Corp |
抗体、遺伝子及びキメラ抗体の製法
|
|
US5990286A
(en)
|
1996-12-18 |
1999-11-23 |
Techniclone, Inc. |
Antibodies with reduced net positive charge
|
|
US6323000B2
(en)
*
|
1996-12-20 |
2001-11-27 |
Clark A. Briggs |
Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
|
|
ATE383430T1
(de)
|
1997-03-20 |
2008-01-15 |
Us Gov Health & Human Serv |
Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumoren
|
|
US6183744B1
(en)
|
1997-03-24 |
2001-02-06 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
US6306393B1
(en)
|
1997-03-24 |
2001-10-23 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
US20070059302A1
(en)
*
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
FR2761994B1
(fr)
|
1997-04-11 |
1999-06-18 |
Centre Nat Rech Scient |
Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
|
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
DK0979281T3
(da)
|
1997-05-02 |
2005-11-21 |
Genentech Inc |
Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele
|
|
DE19725586C2
(de)
|
1997-06-17 |
1999-06-24 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper
|
|
AU8296098A
(en)
|
1997-07-08 |
1999-02-08 |
Board Of Regents, The University Of Texas System |
Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
|
|
US5980893A
(en)
|
1997-07-17 |
1999-11-09 |
Beth Israel Deaconess Medical Center, Inc. |
Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
|
|
US6207805B1
(en)
|
1997-07-18 |
2001-03-27 |
University Of Iowa Research Foundation |
Prostate cell surface antigen-specific antibodies
|
|
US20020187150A1
(en)
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
US6342220B1
(en)
*
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
|
ATE373712T1
(de)
|
1997-10-03 |
2007-10-15 |
Chugai Pharmaceutical Co Ltd |
Natürlicher menschlicher antikörper
|
|
ES2299241T3
(es)
|
1998-03-17 |
2008-05-16 |
Chugai Seiyaku Kabushiki Kaisha |
Preventivos o remedios para enfermedades intestinales inflamatorias que contienen anticuerpos antagonistas del receptor il-6.
|
|
ATE512225T1
(de)
|
1998-04-03 |
2011-06-15 |
Chugai Pharmaceutical Co Ltd |
Humanisierter antikörper gegen den menschlichen gewebefaktor (tf) und verfahren für die konstruktion eines solchen humanisierten antikörpers.
|
|
DE19819846B4
(de)
|
1998-05-05 |
2016-11-24 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Multivalente Antikörper-Konstrukte
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US7081360B2
(en)
*
|
1998-07-28 |
2006-07-25 |
Cadus Technologies, Inc. |
Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
|
|
AU770555B2
(en)
*
|
1998-08-17 |
2004-02-26 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
WO2000018806A1
(de)
|
1998-09-25 |
2000-04-06 |
Horst Lindhofer |
Bispezifische und trispezifische antikörper, die spezifisch mit induzierbaren oberflächenantigenen als operationelle zielstrukturen reagieren
|
|
WO2000032634A1
(en)
|
1998-12-01 |
2000-06-08 |
Protein Design Labs, Inc. |
Humanized antibodies to gamma-interferon
|
|
US7286585B2
(en)
*
|
1998-12-21 |
2007-10-23 |
Finisar Corporation |
Low temperature grown layers with migration enhanced epitaxy adjacent to an InGaAsN(Sb) based active region
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
ES2694002T3
(es)
|
1999-01-15 |
2018-12-17 |
Genentech, Inc. |
Polipéptido que comprende una región Fc de IgG1 humana variante
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6897044B1
(en)
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
|
US6972125B2
(en)
|
1999-02-12 |
2005-12-06 |
Genetics Institute, Llc |
Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
|
|
AR030019A1
(es)
|
1999-05-18 |
2003-08-13 |
Smithkline Beecham Corp |
Anticuerpos monoclonales humanos y fragmentos funcionales del mismo, un procedimiento para su produccion, composiciones farmaceuticas que los comprenden, una molecula aislada de acido nucleico, un plasmido recombinante, una celula hospedante y el uso de dichos anticuerpos para la manufactura de un m
|
|
SK782002A3
(en)
*
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
AT411997B
(de)
|
1999-09-14 |
2004-08-26 |
Baxter Ag |
Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
|
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
|
US20020028178A1
(en)
|
2000-07-12 |
2002-03-07 |
Nabil Hanna |
Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
|
|
AU1290001A
(en)
|
1999-11-18 |
2001-05-30 |
Oxford Biomedica (Uk) Limited |
Antibodies
|
|
AU2578401A
(en)
|
1999-12-14 |
2001-06-25 |
Burnham Institute, The |
Bcl-g polypeptides, encoding nucleic acids and methods of use
|
|
AU2001256174A1
(en)
|
2000-03-01 |
2001-09-12 |
Christoph Gasche |
Mammalian interleukin-10 (il-10) receptor variants
|
|
TWI241345B
(en)
|
2000-03-10 |
2005-10-11 |
Chugai Pharmaceutical Co Ltd |
Apoptosis inducing polypeptide
|
|
JP2003527849A
(ja)
|
2000-03-22 |
2003-09-24 |
キュラゲン コーポレイション |
新規ペプチド及びこれをコードする核酸
|
|
CN1981868A
(zh)
|
2000-03-31 |
2007-06-20 |
拜奥根Idec公司 |
抗细胞因子抗体或拮抗剂与抗-cd20在b细胞淋巴瘤治疗中的联合应用
|
|
AU2001249835A1
(en)
*
|
2000-04-03 |
2001-10-15 |
Oxford Glycosciences (Uk) Ltd. |
Diagnosis and treatment of alzheimer's disease
|
|
AU2001246934A1
(en)
|
2000-04-17 |
2001-10-30 |
Chugai Seiyaku Kabushiki Kaisha |
Agonist antibodies
|
|
WO2001082899A2
(en)
|
2000-05-03 |
2001-11-08 |
Mbt Munich Biotechnology Ag |
Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
|
|
EP1299419A2
(en)
|
2000-05-24 |
2003-04-09 |
Imclone Systems, Inc. |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
|
JP2004512262A
(ja)
|
2000-06-20 |
2004-04-22 |
アイデック ファーマスーティカルズ コーポレイション |
非放射性抗cd20抗体/放射標識抗cd22抗体の組合せ
|
|
CA2415100A1
(en)
|
2000-07-12 |
2002-01-17 |
Idec Pharmaceutical Corporation |
Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications
|
|
WO2002006838A1
(en)
|
2000-07-17 |
2002-01-24 |
Chugai Seiyaku Kabushiki Kaisha |
Method for screening ligand having biological activity
|
|
KR20040023565A
(ko)
|
2000-09-18 |
2004-03-18 |
아이덱 파마슈티칼즈 코포레이션 |
B 세포 고갈/면역조절 항체 조합을 이용한 자가면역질환의 치료를 위한 조합 요법
|
|
ES2332402T5
(es)
|
2000-10-12 |
2018-05-14 |
Genentech, Inc. |
Formulaciones de proteína concentradas de viscosidad reducida
|
|
EP2351838A1
(en)
*
|
2000-10-20 |
2011-08-03 |
Chugai Seiyaku Kabushiki Kaisha |
Crosslinking agonistic antibodies
|
|
AU2002210917B2
(en)
|
2000-10-20 |
2006-05-18 |
Chugai Seiyaku Kabushiki Kaisha |
Degraded TPO agonist antibody
|
|
AU2002210918B2
(en)
|
2000-10-20 |
2006-03-16 |
Chugai Seiyaku Kabushiki Kaisha |
Degraded agonist antibody
|
|
US8034903B2
(en)
*
|
2000-10-20 |
2011-10-11 |
Chugai Seiyaku Kabushiki Kaisha |
Degraded TPO agonist antibody
|
|
AU2000279625A1
(en)
|
2000-10-27 |
2002-05-15 |
Chugai Seiyaku Kabushiki Kaisha |
Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient
|
|
ES2649037T3
(es)
|
2000-12-12 |
2018-01-09 |
Medimmune, Llc |
Moléculas con semividas prolongadas, composiciones y usos de las mismas
|
|
RU2003129528A
(ru)
|
2001-03-07 |
2005-04-10 |
Мерк Патент ГмбХ (DE) |
Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
AU2002307062A1
(en)
|
2001-04-02 |
2002-10-15 |
Purdue Pharma L.P. |
Thrombopoietin (tpo) synthebody for stimulation of platelet production
|
|
CN1294148C
(zh)
|
2001-04-11 |
2007-01-10 |
中国科学院遗传与发育生物学研究所 |
环状单链三特异抗体
|
|
NZ529494A
(en)
*
|
2001-04-13 |
2005-08-26 |
Biogen Idec Inc |
Antibodies to VLA-1
|
|
CA2451493C
(en)
*
|
2001-06-22 |
2016-08-23 |
Chugai Seiyaku Kabushiki Kaisha |
Cell growth inhibitors containing anti-glypican 3 antibody
|
|
EP1399484B1
(en)
*
|
2001-06-28 |
2010-08-11 |
Domantis Limited |
Dual-specific ligand and its use
|
|
US20030049203A1
(en)
|
2001-08-31 |
2003-03-13 |
Elmaleh David R. |
Targeted nucleic acid constructs and uses related thereto
|
|
JP2005507659A
(ja)
|
2001-10-15 |
2005-03-24 |
イミューノメディクス、インコーポレイテッド |
直接ターゲッティング結合タンパク質
|
|
NZ532526A
(en)
|
2001-10-25 |
2007-01-26 |
Genentech Inc |
Compositions comprising a glycoprotein having a Fc region
|
|
US20030190705A1
(en)
*
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
|
DE10156482A1
(de)
|
2001-11-12 |
2003-05-28 |
Gundram Jung |
Bispezifisches Antikörper-Molekül
|
|
BR0307548A
(pt)
*
|
2002-02-11 |
2006-01-17 |
Genentech Inc |
Método de produção de uma variante de anticorpo, variante de anticorpo, composição, ácido nucléico isolado, vetor, célula hospedeira, processo para a produção de uma variante de anticorpo e método de determinação do coeficiente de associação de antìgeno de um anticorpo
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
WO2003074679A2
(en)
|
2002-03-01 |
2003-09-12 |
Xencor |
Antibody optimization
|
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
AU2003227504A1
(en)
*
|
2002-04-15 |
2003-10-27 |
Chugai Seiyaku Kabushiki Kaisha |
METHOD OF CONSTRUCTING scDb LIBRARY
|
|
DE60327199D1
(de)
|
2002-04-26 |
2009-05-28 |
Chugai Pharmaceutical Co Ltd |
Verfahren zum screening auf agonistische antikörper
|
|
EP1510943A4
(en)
|
2002-05-31 |
2007-05-09 |
Celestar Lexico Sciences Inc |
INTERACTION PREDICTION DEVICE
|
|
JP2004086862A
(ja)
|
2002-05-31 |
2004-03-18 |
Celestar Lexico-Sciences Inc |
タンパク質相互作用情報処理装置、タンパク質相互作用情報処理方法、プログラム、および、記録媒体
|
|
AU2003239197A1
(en)
|
2002-06-07 |
2003-12-22 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of |
Novel stable anti-cd22 antibodies
|
|
US20060141456A1
(en)
|
2002-06-12 |
2006-06-29 |
Cynthia Edwards |
Methods and compositions for milieu-dependent binding of a targeted agent to a target
|
|
DE60305919T2
(de)
|
2002-06-28 |
2007-01-18 |
Domantis Limited, Cambridge |
Dual-specifische liganden mit erhöhter halbwertszeit
|
|
CN105884893A
(zh)
|
2002-07-18 |
2016-08-24 |
莫鲁斯有限公司 |
抗体混合物的重组生产
|
|
JP2005535341A
(ja)
|
2002-08-15 |
2005-11-24 |
エピトミスク インコーポレーティッド |
ヒト化ウサギ抗体
|
|
US20060058511A1
(en)
*
|
2002-08-27 |
2006-03-16 |
Chugai Seiyaku Kabushiki Kaisha |
Method for stabilizing protein solution preparation
|
|
US20060235208A1
(en)
|
2002-09-27 |
2006-10-19 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
EP1561759B9
(en)
|
2002-10-11 |
2009-08-26 |
Chugai Seiyaku Kabushiki Kaisha |
Cell death-inducing agent
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
GB0224082D0
(en)
*
|
2002-10-16 |
2002-11-27 |
Celltech R&D Ltd |
Biological products
|
|
PT1558648E
(pt)
|
2002-10-17 |
2012-04-23 |
Genmab As |
Anticorpos monoclonais humanos contra cd20
|
|
CA2511598C
(en)
|
2002-12-24 |
2016-09-13 |
Rinat Neuroscience Corp. |
Anti-ngf antibodies and methods using same
|
|
AU2003303543A1
(en)
|
2002-12-26 |
2004-07-29 |
Chugai Seiyaku Kabushiki Kaisha |
Agonist antibody against heteroreceptor
|
|
DE602004021095D1
(de)
|
2003-01-21 |
2009-06-25 |
Chugai Pharmaceutical Co Ltd |
Verfahren zum screening der leichten kette eines antikörpers
|
|
JP2006517109A
(ja)
|
2003-02-07 |
2006-07-20 |
プロテイン デザイン ラブス インコーポレイテッド |
アンフィレグリン抗体ならびに癌および乾癬を処置するためのその使用
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
WO2004081048A1
(ja)
|
2003-03-13 |
2004-09-23 |
Chugai Seiyaku Kabushiki Kaisha |
変異受容体に対するアゴニスト活性を有するリガンド
|
|
JP2004279086A
(ja)
*
|
2003-03-13 |
2004-10-07 |
Konica Minolta Holdings Inc |
放射線画像変換パネル及び放射線画像変換パネルの製造方法
|
|
US20070003556A1
(en)
*
|
2003-03-31 |
2007-01-04 |
Masayuki Tsuchiya |
Modified antibodies against cd22 and utilization thereof
|
|
GB2400851B
(en)
|
2003-04-25 |
2004-12-15 |
Bioinvent Int Ab |
Identifying binding of a polypeptide to a polypeptide target
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
WO2004106375A1
(en)
*
|
2003-05-30 |
2004-12-09 |
Merus Biopharmaceuticals B.V. I.O. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
|
NZ543712A
(en)
|
2003-06-05 |
2008-06-30 |
Genentech Inc |
Combination therapy for B cell disorders
|
|
JP4794301B2
(ja)
|
2003-06-11 |
2011-10-19 |
中外製薬株式会社 |
抗体の製造方法
|
|
EP1636264A2
(en)
|
2003-06-24 |
2006-03-22 |
MERCK PATENT GmbH |
Tumour necrosis factor receptor molecules with reduced immunogenicity
|
|
US20050033029A1
(en)
|
2003-06-30 |
2005-02-10 |
Jin Lu |
Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
|
|
US7297336B2
(en)
|
2003-09-12 |
2007-11-20 |
Baxter International Inc. |
Factor IXa specific antibodies displaying factor VIIIa like activity
|
|
JP2005101105A
(ja)
|
2003-09-22 |
2005-04-14 |
Canon Inc |
位置決め装置、露光装置、デバイス製造方法
|
|
JP2005112514A
(ja)
|
2003-10-06 |
2005-04-28 |
Tadano Ltd |
伸縮ブーム
|
|
WO2005035754A1
(ja)
|
2003-10-14 |
2005-04-21 |
Chugai Seiyaku Kabushiki Kaisha |
機能蛋白質を代替する二重特異性抗体
|
|
AU2003271174A1
(en)
|
2003-10-10 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
|
WO2005063815A2
(en)
|
2003-11-12 |
2005-07-14 |
Biogen Idec Ma Inc. |
Fcϝ receptor-binding polypeptide variants and methods related thereto
|
|
AU2004290070A1
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
|
|
EP1701979A2
(en)
|
2003-12-03 |
2006-09-20 |
Xencor, Inc. |
Optimized antibodies that target the epidermal growth factor receptor
|
|
SI2383295T1
(sl)
*
|
2003-12-10 |
2015-07-31 |
E.R. Squibb & Sons, L.L.C. |
Protitelesa IP-10 in njihova uporaba
|
|
KR101151477B1
(ko)
|
2003-12-10 |
2012-06-22 |
메다렉스, 인코포레이티드 |
인터페론 알파 항체 및 그의 용도
|
|
JPWO2005056602A1
(ja)
*
|
2003-12-12 |
2008-03-06 |
中外製薬株式会社 |
アゴニスト活性を有する改変抗体のスクリーニング方法
|
|
TW200530266A
(en)
*
|
2003-12-12 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Method of reinforcing antibody activity
|
|
TW200530269A
(en)
|
2003-12-12 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Anti-Mpl antibodies
|
|
EP1710255A4
(en)
*
|
2003-12-12 |
2008-09-24 |
Chugai Pharmaceutical Co Ltd |
MODIFIED ANTIBODIES RECOGNIZING A TRIMER OR LARGER RECEPTOR
|
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
EP1697748A4
(en)
|
2003-12-22 |
2007-07-04 |
Centocor Inc |
METHODS FOR GENERATING MULTIMEDIA MOLECULES
|
|
TW200540186A
(en)
|
2003-12-25 |
2005-12-16 |
Kirin Brewery |
Mutants of anti-CD40 antibody
|
|
US20050266425A1
(en)
*
|
2003-12-31 |
2005-12-01 |
Vaccinex, Inc. |
Methods for producing and identifying multispecific antibodies
|
|
NZ548702A
(en)
|
2004-01-09 |
2009-06-26 |
Pfizer |
Antibodies to MAdCAM
|
|
CN1330448C
(zh)
*
|
2004-02-25 |
2007-08-08 |
苏州宝时得电动工具有限公司 |
往复式电动工具的往复杆平衡机构
|
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
|
EP2053062A1
(en)
|
2004-03-24 |
2009-04-29 |
Xencor, Inc. |
Immunoglobin variants outside the Fc region
|
|
WO2005112564A2
(en)
|
2004-04-15 |
2005-12-01 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Germline and sequence variants of humanized antibodies and methods of making and using them
|
|
TW200605906A
(en)
|
2004-05-11 |
2006-02-16 |
Chugai Pharmaceutical Co Ltd |
Remedy for thrombopenia
|
|
WO2005118635A2
(en)
|
2004-06-03 |
2005-12-15 |
Novimmune S.A. |
Anti-cd3 antibodies and methods of use thereof
|
|
KR100620554B1
(ko)
|
2004-06-05 |
2006-09-06 |
한국생명공학연구원 |
Tag-72에 대한 인간화 항체
|
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
|
US20060019342A1
(en)
*
|
2004-06-25 |
2006-01-26 |
Medimmune, Inc. |
Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis
|
|
DE102004032634A1
(de)
|
2004-07-06 |
2006-02-16 |
Sms Demag Ag |
Verfahren und Einrichtung zum Messen und Regeln der Planheit und/oder der Bandspannungen eines Edelstahlbandes oder einer Edelstahlfolie beim Kaltwalzen in einem Vielwalzengerüst, insbesondere in einem 20-Walzen-Sendizimir-Walzwerk
|
|
PT1674111E
(pt)
|
2004-07-09 |
2010-12-15 |
Chugai Pharmaceutical Co Ltd |
Anticorpo anti-glipicano 3
|
|
DK2471813T3
(en)
|
2004-07-15 |
2015-03-02 |
Xencor Inc |
Optimized Fc variants
|
|
DK2213683T3
(da)
|
2004-08-04 |
2013-09-02 |
Mentrik Biotech Llc |
VARIANT-Fc-REGIONER
|
|
EP1789446A2
(en)
*
|
2004-09-02 |
2007-05-30 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
MX2007002883A
(es)
|
2004-09-13 |
2007-06-15 |
Macrogenics Inc |
Anticuerpos humanizados contra el virus de nilo occidental y usos terapeuticos y profilacticos del mismo.
|
|
US20080233131A1
(en)
|
2004-09-14 |
2008-09-25 |
Richard John Stebbings |
Vaccine
|
|
WO2006031994A2
(en)
|
2004-09-14 |
2006-03-23 |
Xencor, Inc. |
Monomeric immunoglobulin fc domains
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
EP1810979B1
(en)
|
2004-09-22 |
2012-06-20 |
Kyowa Hakko Kirin Co., Ltd. |
STABILIZED HUMAN IgG4 ANTIBODIES
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
AU2005299716B2
(en)
|
2004-10-22 |
2012-09-06 |
Amgen Inc. |
Methods for refolding of recombinant antibodies
|
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
|
US7632497B2
(en)
*
|
2004-11-10 |
2009-12-15 |
Macrogenics, Inc. |
Engineering Fc Antibody regions to confer effector function
|
|
CA2586803C
(en)
|
2004-12-14 |
2012-12-11 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
|
US8728828B2
(en)
|
2004-12-22 |
2014-05-20 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
|
US20090061485A1
(en)
*
|
2004-12-22 |
2009-03-05 |
Chugai Seiyaku Kabushiki Kaisha |
Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited
|
|
WO2006071877A2
(en)
|
2004-12-27 |
2006-07-06 |
Progenics Pharmaceuticals (Nevada), Inc. |
Orally deliverable and anti-toxin antibodies and methods for making and using them
|
|
MX2007007935A
(es)
|
2004-12-28 |
2007-12-06 |
Innate Pharma Sa |
Anticuerpos monoclonales contra nkg2a.
|
|
US8716451B2
(en)
|
2005-01-12 |
2014-05-06 |
Kyowa Hakko Kirin Co., Ltd |
Stabilized human IgG2 and IgG3 antibodies
|
|
EP1858925A2
(en)
*
|
2005-01-12 |
2007-11-28 |
Xencor, Inc. |
Antibodies and fc fusion proteins with altered immunogenicity
|
|
CN101198698B
(zh)
|
2005-03-31 |
2014-03-19 |
中外制药株式会社 |
通过调节多肽缔合制备多肽的方法
|
|
WO2006106903A1
(ja)
|
2005-03-31 |
2006-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
sc(Fv)2構造異性体
|
|
CA2602663A1
(en)
|
2005-03-31 |
2006-10-05 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
EP2824183B1
(en)
|
2005-04-08 |
2020-07-29 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for producing bispecific antibodies
|
|
KR101259655B1
(ko)
|
2005-04-15 |
2013-04-30 |
제넨테크, 인크. |
Hgf 베타 사슬 변이체
|
|
US8008443B2
(en)
|
2005-04-26 |
2011-08-30 |
Medimmune, Llc |
Modulation of antibody effector function by hinge domain engineering
|
|
EP1885755A4
(en)
|
2005-05-05 |
2009-07-29 |
Univ Duke |
CD19 ANTIBODY THERAPY FOR AUTOIMMUNE DISEASES
|
|
WO2006132363A1
(ja)
*
|
2005-06-10 |
2006-12-14 |
Chugai Seiyaku Kabushiki Kaisha |
メグルミンを含有するタンパク質製剤の安定化剤、およびその利用
|
|
JP5085322B2
(ja)
*
|
2005-06-10 |
2012-11-28 |
中外製薬株式会社 |
sc(Fv)2を含有する医薬組成物
|
|
EP3348639A3
(en)
*
|
2005-06-10 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Sc(fv)2 site-directed mutant
|
|
US20070110757A1
(en)
*
|
2005-06-23 |
2007-05-17 |
Ziping Wei |
Antibody formulations having optimized aggregation and fragmentation profiles
|
|
US20070036786A1
(en)
|
2005-07-11 |
2007-02-15 |
Nadine Tuaillon |
Method of treating autoimmune disease using humanized anti-CD16A antibodies
|
|
PL1919503T3
(pl)
|
2005-08-10 |
2015-04-30 |
Macrogenics Inc |
Identyfikacja i inżynieria przeciwciał ze zmiennymi regionami FC oraz sposoby ich stosowania
|
|
SI1915397T1
(sl)
|
2005-08-19 |
2015-05-29 |
Wyeth Llc |
Antagonistična protitelesa proti GDF-8 in uporabe pri zdravljenju ALS in drugih obolenj, povezanih z GDF-8
|
|
EP1928916A2
(en)
|
2005-09-29 |
2008-06-11 |
Viral Logic Systems Technology Corp. |
Immunomodulatory compositions and uses therefor
|
|
WO2007043641A1
(ja)
|
2005-10-14 |
2007-04-19 |
Fukuoka University |
膵島移植における移植膵島障害抑制剤
|
|
AU2006305119B2
(en)
|
2005-10-21 |
2012-12-20 |
Chugai Seiyaku Kabushiki Kaisha |
Agents for treating cardiopathy
|
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
|
EP1820513A1
(en)
|
2006-02-15 |
2007-08-22 |
Trion Pharma Gmbh |
Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
|
|
TW200745163A
(en)
|
2006-02-17 |
2007-12-16 |
Syntonix Pharmaceuticals Inc |
Peptides that block the binding of IgG to FcRn
|
|
CA2644663A1
(en)
|
2006-03-23 |
2007-09-27 |
Kirin Pharma Kabushiki Kaisha |
Agonist antibody to human thrombopoietin receptor
|
|
ES2395969T3
(es)
|
2006-03-24 |
2013-02-18 |
Merck Patent Gmbh |
Dominios de proteínas heterodiméricas genéticamente modificados
|
|
EP3056568B1
(en)
|
2006-03-31 |
2021-09-15 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
JP5144499B2
(ja)
|
2006-03-31 |
2013-02-13 |
中外製薬株式会社 |
二重特異性抗体を精製するための抗体改変方法
|
|
JP5754875B2
(ja)
|
2006-04-07 |
2015-07-29 |
国立大学法人大阪大学 |
筋再生促進剤
|
|
NZ573132A
(en)
|
2006-06-06 |
2012-05-25 |
Glaxo Group Ltd |
Administration of anti-cd3 antibodies in the treatment of autoimmune diseases
|
|
PT2047863E
(pt)
|
2006-06-08 |
2013-10-21 |
Chugai Pharmaceutical Co Ltd |
Prevenção ou tratamento para doença inflamatória
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
US20110236374A1
(en)
|
2007-01-24 |
2011-09-29 |
Kyowa Hakko Kirin Co., Ltd. |
Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2
|
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
|
AU2008234248C1
(en)
|
2007-03-29 |
2015-01-22 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
|
CA2688275A1
(en)
|
2007-05-31 |
2008-12-04 |
Genmab A/S |
Stable igg4 antibodies
|
|
WO2008145141A1
(en)
|
2007-05-31 |
2008-12-04 |
Genmab A/S |
Method for extending the half-life of exogenous or endogenous soluble molecules
|
|
ES2540854T3
(es)
|
2007-06-29 |
2015-07-14 |
Merck Sharp & Dohme Corp. |
Usos de antagonistas MDL-1
|
|
EP2031064A1
(de)
|
2007-08-29 |
2009-03-04 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Verfahren zur Steigerung von Proteintitern
|
|
MX2010002683A
(es)
|
2007-09-14 |
2010-03-26 |
Amgen Inc |
Poblaciones de anticuerpos homogeneos.
|
|
CN101874042B9
(zh)
|
2007-09-26 |
2019-01-01 |
中外制药株式会社 |
利用cdr的氨基酸取代来改变抗体等电点的方法
|
|
AU2008304756B8
(en)
|
2007-09-26 |
2015-02-12 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-IL-6 receptor antibody
|
|
WO2009041734A1
(ja)
|
2007-09-26 |
2009-04-02 |
Kyowa Hakko Kirin Co., Ltd. |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
|
RU2526512C2
(ru)
|
2007-09-26 |
2014-08-20 |
Чугаи Сейяку Кабусики Кайся |
Модифицированная константная область антитела
|
|
KR20150126724A
(ko)
|
2007-09-28 |
2015-11-12 |
추가이 세이야쿠 가부시키가이샤 |
혈장 중 반응속도가 개선된 항-글리피칸-3 항체
|
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
JP5314033B2
(ja)
|
2007-10-22 |
2013-10-16 |
メルク セローノ ソシエテ アノニム |
突然変異IgGFcフラグメントと融合した単一IFN−ベータ
|
|
WO2009072604A1
(ja)
|
2007-12-05 |
2009-06-11 |
Chugai Seiyaku Kabushiki Kaisha |
抗nr10抗体、およびその利用
|
|
BRPI0820452A2
(pt)
|
2007-12-18 |
2015-06-16 |
Bioalliance Cv |
Anticorpos que reconhecendo um epítopo contendo um carboidrato em cd-43 e cea expressos em células cancerosas e métodos de uso dos mesmos.
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US8242247B2
(en)
|
2007-12-21 |
2012-08-14 |
Hoffmann-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
AU2009204501B2
(en)
|
2008-01-07 |
2015-02-12 |
Amgen Inc. |
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
|
|
PL2250279T3
(pl)
|
2008-02-08 |
2016-11-30 |
|
Przeciwciała anty-ifnar1 o zmniejszonym powinowactwie do liganda fc
|
|
SI2274008T1
(sl)
|
2008-03-27 |
2014-08-29 |
Zymogenetics, Inc. |
Sestavki in metode za zaviranje PDGFRBETA in VEGF-A
|
|
CA2721052C
(en)
|
2008-04-11 |
2023-02-21 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
|
EP2899209A1
(en)
|
2008-04-29 |
2015-07-29 |
Abbvie Inc. |
Dual Variable Domain Immunoglobulins and uses thereof
|
|
EP2620448A1
(en)
|
2008-05-01 |
2013-07-31 |
Amgen Inc. |
Anti-hepcidin antibodies and methods of use
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
MX2011003133A
(es)
|
2008-09-26 |
2011-04-21 |
Roche Glycart Ag |
Anticuerpos biespecificos anti-egfr/anti-igf-1r.
|
|
AR074438A1
(es)
|
2008-12-02 |
2011-01-19 |
Pf Medicament |
Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal
|
|
WO2010064090A1
(en)
|
2008-12-02 |
2010-06-10 |
Pierre Fabre Medicament |
Process for the modulation of the antagonistic activity of a monoclonal antibody
|
|
DE202008016028U1
(de)
|
2008-12-04 |
2010-04-15 |
Melitta Haushaltsprodukte Gmbh & Co. Kg |
Behälter zur Aufbewahrung von Gegenständen
|
|
CA2750533A1
(en)
|
2009-01-23 |
2010-07-29 |
Biogen Idec Ma Inc. |
Stabilized fc polypeptides with reduced effector function and methods of use
|
|
TW201613969A
(en)
|
2009-03-05 |
2016-04-16 |
Abbvie Inc |
IL-17 binding proteins
|
|
JP2010210772A
(ja)
|
2009-03-13 |
2010-09-24 |
Dainippon Screen Mfg Co Ltd |
液晶表示装置の製造方法
|
|
EP2409990A4
(en)
|
2009-03-19 |
2013-01-23 |
Chugai Pharmaceutical Co Ltd |
VARIANT OF A CONSTANT ANTIBODY REGION
|
|
JP5717624B2
(ja)
|
2009-03-19 |
2015-05-13 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
|
WO2010120561A1
(en)
|
2009-04-01 |
2010-10-21 |
Genentech, Inc. |
Anti-fcrh5 antibodies and immunoconjugates and methods of use
|
|
SI2417156T1
(sl)
|
2009-04-07 |
2015-06-30 |
Roche Glycart Ag |
Trivalentna, bispecifiäśna protitelesa
|
|
WO2010129304A2
(en)
|
2009-04-27 |
2010-11-11 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
ES2865648T3
(es)
|
2009-06-26 |
2021-10-15 |
Regeneron Pharma |
Anticuerpos biespecíficos fácilmente aislados con formato de inmunoglobulina nativa
|
|
WO2011037158A1
(ja)
|
2009-09-24 |
2011-03-31 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
ES2777901T3
(es)
|
2009-12-25 |
2020-08-06 |
Chugai Pharmaceutical Co Ltd |
Método de modificación de polipéptidos para purificar multímeros polipeptídicos
|
|
PT2519543T
(pt)
|
2009-12-29 |
2016-10-07 |
Emergent Product Dev Seattle |
Proteínas de ligação de heterodímero e suas utilizações
|
|
TWI505838B
(zh)
|
2010-01-20 |
2015-11-01 |
Chugai Pharmaceutical Co Ltd |
Stabilized antibody solution containing
|
|
JP5947727B2
(ja)
|
2010-01-20 |
2016-07-06 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
抗ilt5抗体およびilt5結合抗体断片による免疫調節
|
|
US9023997B2
(en)
|
2010-01-20 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Anti-ILT5 antibodies and ILT5-binding antibody fragments
|
|
WO2011108502A1
(ja)
|
2010-03-02 |
2011-09-09 |
協和発酵キリン株式会社 |
改変抗体組成物
|
|
WO2011108714A1
(ja)
|
2010-03-04 |
2011-09-09 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
AU2011225716A1
(en)
|
2010-03-11 |
2012-09-27 |
Pfizer Inc. |
Antibodies with pH dependent antigen binding
|
|
US9162161B2
(en)
|
2010-03-31 |
2015-10-20 |
Jsr Corporation |
Filler for affinity chromatography
|
|
US9150663B2
(en)
|
2010-04-20 |
2015-10-06 |
Genmab A/S |
Heterodimeric antibody Fc-containing proteins and methods for production thereof
|
|
KR101860963B1
(ko)
|
2010-04-23 |
2018-05-24 |
제넨테크, 인크. |
이종다량체 단백질의 생산
|
|
WO2011143545A1
(en)
|
2010-05-14 |
2011-11-17 |
Rinat Neuroscience Corporation |
Heterodimeric proteins and methods for producing and purifying them
|
|
IL299365A
(en)
|
2010-05-27 |
2023-02-01 |
Genmab As |
Monoclonal antibodies against 2HER
|
|
CN103052649B
(zh)
|
2010-07-29 |
2015-12-16 |
Xencor公司 |
具有修改的等电点的抗体
|
|
AU2011288412A1
(en)
|
2010-08-13 |
2013-02-21 |
Medimmune Limited |
Monomeric polypeptides comprising variant Fc regions and methods of use
|
|
AU2011325833C1
(en)
|
2010-11-05 |
2017-07-13 |
Zymeworks Bc Inc. |
Stable heterodimeric antibody design with mutations in the Fc domain
|
|
KR101962483B1
(ko)
|
2010-11-17 |
2019-03-29 |
추가이 세이야쿠 가부시키가이샤 |
혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
|
|
EP4279513A3
(en)
|
2010-11-30 |
2024-02-28 |
Chugai Seiyaku Kabushiki Kaisha |
Cytotoxicity-inducing therapeutic agent
|
|
EP2699263A4
(en)
|
2011-04-20 |
2014-12-24 |
Liquidating Trust |
METHOD FOR REDUCING AN UNWANTED IMMUNE RESPONSE TO A FOREIGN-LIKE IN A HUMAN PATIENT WITH ANTI-CD4 ANTIBODIES OR CD4-BINDING FRAGMENTS THEREOF OR CD4-BINDING MOLECULES
|
|
DK2771364T3
(da)
|
2011-10-27 |
2019-08-19 |
Genmab As |
Fremstilling af heterodimere proteiner
|
|
EP2787078B1
(en)
|
2011-10-31 |
2019-05-22 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain
|
|
WO2013063702A1
(en)
|
2011-11-04 |
2013-05-10 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
|
PL2822587T3
(pl)
|
2012-03-08 |
2016-07-29 |
Hoffmann La Roche |
Preparat przeciwciała abeta
|
|
CA2867020C
(en)
|
2012-03-13 |
2022-11-15 |
Novimmune S.A. |
Readily isolated bispecific antibodies with native immunoglobulin format
|
|
EP2832856A4
(en)
|
2012-03-29 |
2016-01-27 |
Chugai Pharmaceutical Co Ltd |
ANTI-LAMP5 ANTIBODIES AND USE THEREOF
|
|
PT2838917T
(pt)
|
2012-04-20 |
2019-09-12 |
Merus Nv |
Métodos e meios para a produção de moléculas similares a ig heterodiméricas
|
|
AU2013302925B2
(en)
|
2012-08-13 |
2018-07-05 |
Regeneron Pharmaceuticals, Inc. |
Anti-PCSK9 antibodies with pH-dependent binding characteristics
|
|
EP2905290B1
(en)
|
2012-10-05 |
2019-12-04 |
Kyowa Kirin Co., Ltd. |
Heterodimeric protein composition
|
|
AU2013337578C1
(en)
|
2012-11-02 |
2018-04-12 |
Zymeworks Inc. |
Crystal structures of heterodimeric Fc domains
|
|
ES2699599T3
(es)
|
2013-03-15 |
2019-02-11 |
Abbvie Biotherapeutics Inc |
Variantes de Fc
|
|
AU2014325063B2
(en)
|
2013-09-27 |
2019-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide heteromultimer
|
|
MY176522A
(en)
|
2013-11-04 |
2020-08-13 |
Ichnos Sciences SA |
Production of t cell retargeting hetero-dimeric immunoglobulins
|
|
TWI831106B
(zh)
|
2014-06-20 |
2024-02-01 |
日商中外製藥股份有限公司 |
用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物
|
|
JP6630036B2
(ja)
|
2014-09-30 |
2020-01-15 |
Jsr株式会社 |
標的物の精製方法、及び、ミックスモード用担体
|
|
SG10201907215QA
(en)
|
2015-02-05 |
2019-09-27 |
Chugai Pharmaceutical Co Ltd |
Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof
|
|
WO2016159213A1
(ja)
|
2015-04-01 |
2016-10-06 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
CN107454906B
(zh)
|
2015-04-17 |
2022-05-27 |
豪夫迈·罗氏有限公司 |
使用凝固因子和多特异性抗体的联合治疗
|
|
JP2018123055A
(ja)
|
2015-04-24 |
2018-08-09 |
公立大学法人奈良県立医科大学 |
血液凝固第viii因子(fviii)の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第xi因子(fxi)異常症の予防および/または治療に用いられる医薬組成物
|
|
BR112018009312A8
(pt)
|
2015-12-28 |
2019-02-26 |
Chugai Pharmaceutical Co Ltd |
método para promover eficiência de purificação de polipeptídeo contendo região de fc
|
|
SG11201807765PA
(en)
|
2016-04-28 |
2018-10-30 |
Chugai Pharmaceutical Co Ltd |
Antibody-containing preparation
|
|
TW201836636A
(zh)
|
2017-03-31 |
2018-10-16 |
公立大學法人奈良縣立醫科大學 |
含有替代凝血因子viii功能之多特異性抗原結合分子之用於預防和/或治療凝血因子ix異常症的醫藥組合物
|