US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
US8093357B2
(en)
|
2002-03-01 |
2012-01-10 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
ES2429112T3
(es)
*
|
2002-04-10 |
2013-11-13 |
Genentech, Inc. |
Variantes de anticuerpos anti-HER2
|
US20060235208A1
(en)
*
|
2002-09-27 |
2006-10-19 |
Xencor, Inc. |
Fc variants with optimized properties
|
US8388955B2
(en)
*
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
US9051373B2
(en)
|
2003-05-02 |
2015-06-09 |
Xencor, Inc. |
Optimized Fc variants
|
KR101412271B1
(ko)
*
|
2003-05-09 |
2014-06-25 |
듀크 유니버시티 |
Cd20-특이적 항체 및 이를 이용한 방법
|
US8597911B2
(en)
*
|
2003-06-11 |
2013-12-03 |
Chugai Seiyaku Kabushiki Kaisha |
Process for producing antibodies
|
AU2004253868B2
(en)
*
|
2003-06-13 |
2011-06-16 |
Biogen Ma Inc. |
Aglycosyl anti-CD154 (CD40 ligand) antibodies and uses thereof
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
EP1737890A2
(en)
|
2004-03-24 |
2007-01-03 |
Xencor, Inc. |
Immunoglobulin variants outside the fc region
|
US20060018902A1
(en)
*
|
2004-04-09 |
2006-01-26 |
Reilly Edward B |
Antibodies to erythropoietin receptor and uses thereof
|
US20050227289A1
(en)
*
|
2004-04-09 |
2005-10-13 |
Reilly Edward B |
Antibodies to erythropoietin receptor and uses thereof
|
US20150010550A1
(en)
|
2004-07-15 |
2015-01-08 |
Xencor, Inc. |
OPTIMIZED Fc VARIANTS
|
WO2006033702A2
(en)
*
|
2004-07-26 |
2006-03-30 |
Biogen Idec Ma Inc. |
Anti-cd154 antibodies
|
DK1817340T3
(da)
|
2004-11-12 |
2012-08-13 |
Xencor Inc |
Fc-varianter med ændret binding til fcrn
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
US8546543B2
(en)
|
2004-11-12 |
2013-10-01 |
Xencor, Inc. |
Fc variants that extend antibody half-life
|
CA2600929A1
(en)
*
|
2005-03-04 |
2006-09-14 |
Biogen Idec Ma Inc. |
Methods of humanizing immunoglobulin variable regions through rational modification of complementarity determining residues
|
WO2006106905A1
(ja)
*
|
2005-03-31 |
2006-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
会合制御によるポリペプチド製造方法
|
US20100261288A1
(en)
|
2005-06-13 |
2010-10-14 |
Fortebio, Inc. |
Tip tray assembly for optical sensors
|
EP1931709B1
(en)
|
2005-10-03 |
2016-12-07 |
Xencor, Inc. |
Fc variants with optimized fc receptor binding properties
|
AU2006302254B2
(en)
|
2005-10-06 |
2011-05-26 |
Xencor, Inc. |
Optimized anti-CD30 antibodies
|
US8128933B2
(en)
*
|
2005-11-23 |
2012-03-06 |
Acceleron Pharma, Inc. |
Method of promoting bone growth by an anti-activin B antibody
|
CA3045808C
(en)
|
2005-11-23 |
2022-08-16 |
Acceleron Pharma, Inc. |
Activin-actriia antagonists and uses for promoting bone growth
|
US20070161042A1
(en)
*
|
2006-01-11 |
2007-07-12 |
Fortebio, Inc. |
Methods for characterizing molecular interactions
|
KR101413615B1
(ko)
*
|
2006-03-23 |
2014-07-18 |
바이오악틱 뉴로사이언스 에이비 |
인간 프로토피브릴에 선택적인 개선된 항체 및 이의 용도
|
ES2568436T3
(es)
*
|
2006-03-31 |
2016-04-29 |
Chugai Seiyaku Kabushiki Kaisha |
Procedimiento para controlar la farmacocinética en sangre de anticuerpos
|
US9670269B2
(en)
*
|
2006-03-31 |
2017-06-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of modifying antibodies for purification of bispecific antibodies
|
SI2059536T1
(sl)
|
2006-08-14 |
2014-06-30 |
Xencor, Inc. |
Optimirana protitelesa, ki ciljajo CD19
|
WO2008033535A2
(en)
*
|
2006-09-14 |
2008-03-20 |
Fortebio, Inc. |
Amine-reactive biosensor
|
AU2007299843B2
(en)
|
2006-09-18 |
2012-03-08 |
Xencor, Inc |
Optimized antibodies that target HM1.24
|
WO2008063932A2
(en)
*
|
2006-11-10 |
2008-05-29 |
Genentech, Inc. |
Method for treating age-related macular degeneration
|
US8895016B2
(en)
|
2006-12-18 |
2014-11-25 |
Acceleron Pharma, Inc. |
Antagonists of activin-actriia and uses for increasing red blood cell levels
|
ES2415666T3
(es)
|
2007-02-01 |
2013-07-26 |
Acceleron Pharma, Inc. |
Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIa para uso en la prevención o el tratamiento de metástasis de cáncer de mama o pérdida ósea relacionada con el cáncer de mama
|
TW201907946A
(zh)
|
2007-02-02 |
2019-03-01 |
美商艾瑟勒朗法瑪公司 |
衍生自ActRIIB的變體與其用途
|
EP2484372A1
(en)
|
2007-02-09 |
2012-08-08 |
Acceleron Pharma, Inc. |
Activin-ActRIIa Antagonists and Uses for Promoting Bone Growth in Cancer Patients
|
CA2699936A1
(en)
|
2007-09-18 |
2009-03-26 |
Acceleron Pharma Inc. |
Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
|
EP3689912A1
(en)
|
2007-09-26 |
2020-08-05 |
Chugai Seiyaku Kabushiki Kaisha |
Method of modifying isoelectric point of antibody via amino acid substitution in cdr
|
SG10201605394SA
(en)
|
2007-09-26 |
2016-08-30 |
Chugai Pharmaceutical Co Ltd |
Modified Antibody Constant Region
|
ES2532461T3
(es)
|
2007-12-26 |
2015-03-27 |
Xencor, Inc. |
Variantes de FC con enlazamiento alterado a FCRN
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至her2結構域ii之抗體及其酸性變異體的組合物
|
EP4238993A3
(en)
|
2008-04-11 |
2023-11-29 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
CA2722466A1
(en)
|
2008-04-29 |
2009-11-05 |
Tariq Ghayur |
Dual variable domain immunoglobulins and uses thereof
|
CA2722622C
(en)
*
|
2008-05-07 |
2018-01-02 |
Novo Nordisk A/S |
Humanized antibodies against human interferon-alpha
|
CA2725666A1
(en)
|
2008-06-03 |
2009-12-10 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
AU2009256250B2
(en)
|
2008-06-03 |
2013-05-30 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
NZ590074A
(en)
|
2008-07-08 |
2012-12-21 |
Abbott Lab |
Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
|
HRP20230761T1
(hr)
|
2008-08-14 |
2023-10-13 |
Acceleron Pharma Inc. |
Gdf zamke
|
US8216997B2
(en)
|
2008-08-14 |
2012-07-10 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
AU2009308707A1
(en)
*
|
2008-10-31 |
2010-05-06 |
Biogen Idec Ma Inc. |
LIGHT targeting molecules and uses thereof
|
JP5787446B2
(ja)
|
2009-03-19 |
2015-09-30 |
中外製薬株式会社 |
抗体定常領域改変体
|
US9228017B2
(en)
|
2009-03-19 |
2016-01-05 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
RU2595379C2
(ru)
|
2009-04-16 |
2016-08-27 |
АббВай Биотерапеутикс Инк. |
АНТИТЕЛА ПРОТИВ TNF-α И ИХ ПРИМЕНЕНИЯ
|
WO2010129532A2
(en)
*
|
2009-05-05 |
2010-11-11 |
Trustees Of Boston University |
Method and device for rapid detection of bacterial antibiotic resistance/susceptibility
|
AU2010258931B2
(en)
|
2009-06-08 |
2015-04-23 |
Acceleron Pharma Inc. |
Methods for increasing thermogenic adipocytes
|
US8293881B2
(en)
|
2009-06-12 |
2012-10-23 |
Acceleron Pharma Inc. |
Isolated nucleic acid encoding a truncated ActRIIB fusion protein
|
EP2443150B1
(en)
*
|
2009-06-17 |
2015-01-21 |
AbbVie Biotherapeutics Inc. |
Anti-vegf antibodies and their uses
|
IN2012DN02737A
(pt)
|
2009-09-01 |
2015-09-11 |
Abbott Lab |
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
EP2481752B1
(en)
|
2009-09-24 |
2016-11-09 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
KR20140015139A
(ko)
|
2009-10-15 |
2014-02-06 |
애브비 인코포레이티드 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
ES2658292T3
(es)
|
2009-11-17 |
2018-03-09 |
Acceleron Pharma, Inc. |
Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular
|
CA2781682A1
(en)
|
2009-12-04 |
2011-06-09 |
Genentech, Inc. |
Multispecific antibodies, antibody analogs, compositions, and methods
|
WO2011084496A1
(en)
*
|
2009-12-16 |
2011-07-14 |
Abbott Biotherapeutics Corp. |
Anti-her2 antibodies and their uses
|
US8362210B2
(en)
|
2010-01-19 |
2013-01-29 |
Xencor, Inc. |
Antibody variants with enhanced complement activity
|
JP5889181B2
(ja)
|
2010-03-04 |
2016-03-22 |
中外製薬株式会社 |
抗体定常領域改変体
|
FR2958753B1
(fr)
*
|
2010-04-13 |
2018-03-16 |
Institut De Recherche Pour Le Developpement (Ird) |
Construction antigenique et ses applications pour le depistage de trypanosomoses chez l'homme et l'animal
|
MX2012012736A
(es)
*
|
2010-05-07 |
2013-02-26 |
Hoffmann La Roche |
Metodo de diagnostico para la deteccion de celulas ex vivo.
|
CA2807014A1
(en)
|
2010-08-03 |
2012-02-09 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
TW201211252A
(en)
|
2010-08-26 |
2012-03-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
CN103154741B
(zh)
*
|
2010-09-17 |
2016-02-03 |
国立大学法人东北大学 |
含有抗体作为成分的医药品的有效性的判定方法
|
EP2638065A4
(en)
|
2010-11-08 |
2014-04-09 |
Acceleron Pharma Inc |
ACTRIIA BINDING AGENTS AND USES THEREOF
|
MY166429A
(en)
|
2010-11-17 |
2018-06-26 |
Chugai Pharmaceutical Co Ltd |
Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
|
KR102147548B1
(ko)
|
2011-02-25 |
2020-08-24 |
추가이 세이야쿠 가부시키가이샤 |
FcγRIIb 특이적 Fc 항체
|
WO2012133047A1
(ja)
*
|
2011-03-25 |
2012-10-04 |
コニカミノルタエムジー株式会社 |
免疫組織染色法、およびこれを用いた抗体医薬の有効性を判定する方法
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
TW201817745A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
US11851476B2
(en)
|
2011-10-31 |
2023-12-26 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain
|
UY34558A
(es)
|
2011-12-30 |
2013-07-31 |
Abbvie Inc |
Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17
|
US9777067B2
(en)
|
2012-09-27 |
2017-10-03 |
Massachusetts Institute Of Technology |
HER2- and VEGF-A-binding proteins with enhanced stability
|
AU2013337775B2
(en)
|
2012-11-01 |
2017-03-30 |
Abbvie Inc. |
Anti-VEGF/DLL4 dual variable domain immunoglobulins and uses thereof
|
WO2014071158A1
(en)
|
2012-11-02 |
2014-05-08 |
Celgene Corporation |
Activin-actrii antagonists and uses for treating bone and other disorders
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
US20140154255A1
(en)
|
2012-11-30 |
2014-06-05 |
Abbvie Biotherapeutics Inc. |
Anti-vegf antibodies and their uses
|
CN105324396A
(zh)
|
2013-03-15 |
2016-02-10 |
艾伯维公司 |
针对IL-1β和/或IL-17的双重特异性结合蛋白
|
KR102441231B1
(ko)
|
2013-09-27 |
2022-09-06 |
추가이 세이야쿠 가부시키가이샤 |
폴리펩티드 이종 다량체의 제조방법
|
CA2951926C
(en)
|
2014-06-13 |
2023-01-10 |
Acceleron Pharma, Inc. |
Methods and compositions for treating ulcers
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
MA41052A
(fr)
|
2014-10-09 |
2017-08-15 |
Celgene Corp |
Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
|
ES2946160T3
(es)
|
2014-12-03 |
2023-07-13 |
Celgene Corp |
Antagonistas de activina-ActRII y usos para tratar síndrome mielodisplásico
|
US10093733B2
(en)
|
2014-12-11 |
2018-10-09 |
Abbvie Inc. |
LRP-8 binding dual variable domain immunoglobulin proteins
|
SG11201607165YA
(en)
|
2014-12-19 |
2016-09-29 |
Chugai Pharmaceutical Co Ltd |
Anti-c5 antibodies and methods of use
|
TWI808330B
(zh)
|
2014-12-19 |
2023-07-11 |
日商中外製藥股份有限公司 |
抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法
|
TW202248212A
(zh)
|
2015-02-05 |
2022-12-16 |
日商中外製藥股份有限公司 |
包含離子濃度依賴之抗原結合域的抗體、Fc區變體、IL-8結合抗體與其用途
|
TW202339800A
(zh)
|
2015-02-27 |
2023-10-16 |
日商中外製藥股份有限公司 |
Il-6受體抗體用於製備醫藥組成物的用途
|
EP3279216A4
(en)
|
2015-04-01 |
2019-06-19 |
Chugai Seiyaku Kabushiki Kaisha |
PROCESS FOR PREPARING POLYPEPTIDE HETERO OLIGOMER
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
EP3394098A4
(en)
|
2015-12-25 |
2019-11-13 |
Chugai Seiyaku Kabushiki Kaisha |
ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE
|
AU2016381992B2
(en)
|
2015-12-28 |
2024-01-04 |
Chugai Seiyaku Kabushiki Kaisha |
Method for promoting efficiency of purification of Fc region-containing polypeptide
|
AU2017233658B2
(en)
|
2016-03-14 |
2023-09-21 |
Chugai Seiyaku Kabushiki Kaisha |
Cell injury inducing therapeutic drug for use in cancer therapy
|
EP3452103A1
(en)
|
2016-04-15 |
2019-03-13 |
The Trustees Of The University Of Pennsylvania |
Compositions for treatment of wet age-related macular degeneration
|
EP3494991A4
(en)
|
2016-08-05 |
2020-07-29 |
Chugai Seiyaku Kabushiki Kaisha |
COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATING TO IL-8
|
US11851486B2
(en)
|
2017-05-02 |
2023-12-26 |
National Center Of Neurology And Psychiatry |
Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
|
TW202034958A
(zh)
*
|
2018-10-30 |
2020-10-01 |
丹麥商珍美寶股份有限公司 |
使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法
|