JP2004510698A5 - - Google Patents
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- Publication number
- JP2004510698A5 JP2004510698A5 JP2002500895A JP2002500895A JP2004510698A5 JP 2004510698 A5 JP2004510698 A5 JP 2004510698A5 JP 2002500895 A JP2002500895 A JP 2002500895A JP 2002500895 A JP2002500895 A JP 2002500895A JP 2004510698 A5 JP2004510698 A5 JP 2004510698A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- phosphate
- alkyl
- acyl
- flavivirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 bromo, chloro, fluoro, iodo Chemical group 0.000 description 30
- 150000001875 compounds Chemical class 0.000 description 22
- 229910019142 PO4 Inorganic materials 0.000 description 20
- 239000003814 drug Substances 0.000 description 20
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 20
- 239000010452 phosphate Substances 0.000 description 20
- 150000003839 salts Chemical class 0.000 description 20
- 241000710831 Flavivirus Species 0.000 description 16
- 229940079593 drug Drugs 0.000 description 12
- 125000002252 acyl group Chemical group 0.000 description 10
- 206010054261 Flavivirus infection Diseases 0.000 description 8
- 241000710778 Pestivirus Species 0.000 description 8
- 208000004571 Pestivirus Infections Diseases 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 8
- 239000003443 antiviral agent Substances 0.000 description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 125000005354 acylalkyl group Chemical group 0.000 description 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 125000005140 aralkylsulfonyl group Chemical group 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 235000012000 cholesterol Nutrition 0.000 description 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 4
- 239000001177 diphosphate Substances 0.000 description 4
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 4
- 235000011180 diphosphates Nutrition 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 4
- 150000004712 monophosphates Chemical class 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 150000003904 phospholipids Chemical class 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 150000003459 sulfonic acid esters Chemical class 0.000 description 4
- 239000001226 triphosphate Substances 0.000 description 4
- 235000011178 triphosphate Nutrition 0.000 description 4
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 0 CC1([C@@]([n]2c(ncnc3*)c3nc2)O[C@](C[N+]([O-])=O)C1O)O Chemical compound CC1([C@@]([n]2c(ncnc3*)c3nc2)O[C@](C[N+]([O-])=O)C1O)O 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 2
- 229940126062 Compound A Drugs 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20767400P | 2000-05-26 | 2000-05-26 | |
| US60/207,674 | 2000-05-26 | ||
| US28327601P | 2001-04-11 | 2001-04-11 | |
| US60/283,276 | 2001-04-11 | ||
| PCT/US2001/016687 WO2001092282A2 (en) | 2000-05-26 | 2001-05-23 | Methods and compositions for treating flaviviruses and pestiviruses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267194A Division JP2013079257A (ja) | 2000-05-26 | 2012-12-06 | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510698A JP2004510698A (ja) | 2004-04-08 |
| JP2004510698A5 true JP2004510698A5 (enExample) | 2008-07-10 |
| JP5230052B2 JP5230052B2 (ja) | 2013-07-10 |
Family
ID=26902464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002500895A Expired - Lifetime JP5230052B2 (ja) | 2000-05-26 | 2001-05-23 | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
| JP2012267194A Pending JP2013079257A (ja) | 2000-05-26 | 2012-12-06 | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267194A Pending JP2013079257A (ja) | 2000-05-26 | 2012-12-06 | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (9) | US6812219B2 (enExample) |
| EP (2) | EP1294735A2 (enExample) |
| JP (2) | JP5230052B2 (enExample) |
| KR (2) | KR20080021797A (enExample) |
| CN (2) | CN101099745A (enExample) |
| AP (2) | AP1727A (enExample) |
| AR (1) | AR032883A1 (enExample) |
| AU (2) | AU2001272923A1 (enExample) |
| BR (1) | BR0111196A (enExample) |
| CA (1) | CA2410579C (enExample) |
| CZ (1) | CZ301182B6 (enExample) |
| EA (2) | EA007867B1 (enExample) |
| IL (1) | IL153020A0 (enExample) |
| MA (1) | MA26916A1 (enExample) |
| MX (1) | MXPA02011691A (enExample) |
| NO (1) | NO327249B1 (enExample) |
| NZ (2) | NZ536570A (enExample) |
| OA (1) | OA12382A (enExample) |
| PE (1) | PE20020051A1 (enExample) |
| PL (1) | PL359169A1 (enExample) |
| TW (1) | TW200425898A (enExample) |
| WO (1) | WO2001092282A2 (enExample) |
| YU (1) | YU92202A (enExample) |
| ZA (2) | ZA200210112B (enExample) |
Families Citing this family (241)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| KR20090089922A (ko) * | 2000-10-18 | 2009-08-24 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| US7105499B2 (en) | 2001-01-22 | 2006-09-12 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| MXPA03006514A (es) | 2001-01-22 | 2004-12-02 | Merck & Co Inc | Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico. |
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| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| WO2003000200A2 (en) | 2001-06-22 | 2003-01-03 | Pharmasset Ltd. | β-2'-OR 3'-HALONUCLEOSIDES |
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| WO2003062256A1 (en) * | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents |
| EP1572705A2 (en) * | 2002-01-17 | 2005-09-14 | Ribapharm, Inc. | Sugar modified nucleosides as viral replication inhibitors |
| US7217815B2 (en) | 2002-01-17 | 2007-05-15 | Valeant Pharmaceuticals North America | 2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents |
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| US7247621B2 (en) * | 2002-04-30 | 2007-07-24 | Valeant Research & Development | Antiviral phosphonate compounds and methods therefor |
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| AU2003247084B9 (en) * | 2002-06-28 | 2018-07-26 | Centre National De La Recherche Scientifique | Modified 2' and 3'-nucleoside prodrugs for treating flaviridae infections |
| KR20050035194A (ko) * | 2002-06-28 | 2005-04-15 | 이데닉스 (케이만) 리미티드 | 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘 |
| KR20050055630A (ko) * | 2002-06-28 | 2005-06-13 | 이데닉스 (케이만) 리미티드 | 플라비비리다에 감염 치료를 위한 1'-, 2'- 및 3'-변형된뉴클레오시드 유도체 |
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2001
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- 2001-05-23 CN CNA2007100896090A patent/CN101099745A/zh active Pending
- 2001-05-23 WO PCT/US2001/016687 patent/WO2001092282A2/en not_active Ceased
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