FI94767B - För icke-terapeutisk användning avsedda fullständiga och partiella estrar av hyaluronsyra - Google Patents
För icke-terapeutisk användning avsedda fullständiga och partiella estrar av hyaluronsyra Download PDFInfo
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- FI94767B FI94767B FI901341A FI901341A FI94767B FI 94767 B FI94767 B FI 94767B FI 901341 A FI901341 A FI 901341A FI 901341 A FI901341 A FI 901341A FI 94767 B FI94767 B FI 94767B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Claims (27)
1. För icke-terapeutisk användning avsedda fullständiga eller partiella estrar av hyaluronsyra och alkoholer av den alifa-5 tiska, aralifatiska eller cykloalifatiska serien saint salter av dessa partiella estrar bildade med oorganiska eller or-ganiska syror, med undantag för hyaluronsyrans fullständiga metylester.
2. Hyaluronsyrans estrar och deras salter enligt patentkrav 1, kännetecknade av att alifatiska seriens alkoholer uppvisar högst 34 kolatomer och är osubstituerade eller subs-tituerade med en eller tvä funktionella grupper, vilka utgörs av amino-, hydroxi-, merkapto-, aldehyd-, keto-, karboxi-, 15 vätekarbyl- eller divätekarbylaminogrupper, eter-, ester-, tioeter-, tioester-, acetal-, ketal-, karbalkoxi-, karbamid-eller substituoerade karbamidgrupper, varvid i vätekarbylradi-kalerna uppvisar en eller tvä alkylgrupper i dessa funk-tionellt modifierade grupper högst 6 kolatomer, och varvid 20 kolatomkedjorna i dessa alkoholer av den alifatiska serien kan uppvisa heteroatomer, som utgörs av syre, svavel eller kväve.
3. Hyaluronsyrans estrar och deras salter enligt patentkrav 2, kännetecknade av att den förestrande alkoholkom-25 ponenten är härledd frän etylalkohol, propylalkohol, isopropy-lalkohol, n-butylalkohol, isobutylalkohol, t-butylalkohol, amylalkohol, pentylalkohol, hexylalkohol, oktylalkohol, ety-lenglykol, propylenglykol, butylenglykol eller glycerin.
4. Hyaluronsyrans estrar och deras salter enligt patentkrav 1, kännetecknade av att alkoholerna av den aralifa-. **. tiska serien utgörs av sädana som uppvisar högst en bensenrest och den alifatiska kedjan har högst 4 kolatomer och bensenres-ten kan säsom substituenter uppvisa 1-3 metyl- eller hydro-35 xigrupper eller halogenatomer, och den alifatiska kedjan kan säsom substituenter uppvisa högst en eller tvä funktionella grupper, som utgörs av fria aminogrupper, mono- eller diety- ™ 94767 lgrupper eller pyrrolidin- eller piperidingrupper.
5. Hyaluronsyrans estrar och deras salter enligt patentkrav 1, kännetecknade av att alkoholen är bensenalkohol, 5 etanol eller propanol.
6. Hyaluronsyrans estrar och deras salter enligt patentkrav l, kännetecknade av att alkoholen utgörs av en alkohol av den cykloalifatiska eller alifatisk-cykloalifatiska 10 serien och den är härledd frän en mono- eller polycyklisk kolkarbid med högst 34 kolatomer.
7. Sait av hyaluronsyraester enligt nägot av patentkraven 1 -6, kännetecknat av att det är bildat av en 15 alkalimetall eller en alkalisk jordartsmetall, magnesium eller aluminium.
8. Salt av hyaluronsyraester enligt patentkrav 7, kännetecknat av att det utgörs av ett natrium- eller ett 2. ammoniumsalt.
9. Förening enligt patentkrav 1, kännetecknad av att den utgörs av 25 en partiell propylester av hyaluronsyra, väri 50 % av karbo- xylgrupperna för förestrade och 50 % av karboxylgrupperna är i formen av ett natriumsalt, en partiell isopropylester av hyaluronsyra, väri 50 % av 30 karboxylgrupperna är förestrade och 50 % av karboxylgrupperna är i formen av ett natriumsalt, • en partiell propylester av hyaluronsyra, väri 85 % av av karboxylgrupperna är förestrade och 15 % av karboxylgrupperna är 35. formen av ett natriumsalt, en partiell etylester av hyaluronsyra, väri 75 % av 71 94767 karboxylgrupperna är förestrade och 25 % av karboxylgrupperna är i formen av ett natriumsalt, en partiell metylester av hyaluronsyra, väri 75 % 5 av karboxylgrupperna är förestrade och 25 % av karboxylgrup perna är i formen av ett natriumsalt, hyaluronsyrans fullständiga etylester, 10 hyaluronsyrans fullständiga propylester, en partiell butylester av hyaluronsyra, väri 50 % av karboxylgrupperna är förestrade och 50 % av karboxylgrupperna är i formen av ett natriumsalt, 15 en partiell etoxikarbonylmetylester av hyaluronsyra, väri 75 % av karboxylgrupperna är förestrade och 25 % av karboxylgrupperna är i formen av ett natiumsalt, 20 hyaluronsyrans fullständiga pentylester, hyaluronsyrans fullständiga isopentylester, hyaluronsyrans fullständiga bensylester, 25 ’ hyaluronsyrans fullständiga /3-fenyletylester.
10. Estrar enligt nägot av patentkraven 1-9, känne-tecknade av att hyaluronsyraestrarna är härledda frän 30 hela det hyaluronsyraextrakt som erhälls frän tuppkammar eller salter av dessa syror, varvid molekylvikten hos hyaluronsyror-na uppgär till 8...13 miljoner.
11. Estrar enligt nägot av patentkraven 1-9, känne-35 tecknade av att hyaluronsyraestern är härledd frän en hyaluronsyrafraktion, vars molekylvikt uppgär tili ca 90... 80 % - 0,23 % av den totala molekylvikten för en hyaluronsyra, • « 72 94767 vars molekylvikt uppgär till 13 miljoner.
12. Estrar enligt nägot av patentkraven 1-9, k ä n n e -tecknade av att hyaluronsyraestrarna är härledda frän 5 en molekylfraktion som i beskrivningen kallas Hyalastine och vars genomsnittliga molekylvikt uppgär tili ca 50.000 - 100.-000 och som är väsentligen fri frän hyaluronsyror med molekyl-vikter under 30.000.
13. Estrar enligt nägot av patentkraven 1-9, känne- tecknade av att hyaluronsyraestrarna är härledda frän en molekylfraktion som i beskrivningen kallas Hyalectin och vars genomsnittliga molekylvikt uppgär tili ca 500.000 - 730.000 och som är väsentligen fri frän hyaluronsyror med 15 molekylvikter under 30.000.
14. Användningen av en ester enligt nägot av patentkraven 1 -9 eller ett sait därav eller av hyaluronsyrans fullständiga metylester i sanitets- eller kirurgiska produkter. 20
15. Användningen av en ester enligt nägot av patentkraven 1 -9 eller ett sait därav eller av hyaluronsyrans fullständiga metylester i sanitets- eller kirurgiska produkter i form av folier, trädar, suturer eller nät. 25 t
16. Förfarande för framställning av fullständiga och partiella hyaluronsyraestrar och salter därav, vilka är avsedda för icke-terapeutiska användning, kännetecknat av att hyaluronsyrans karboxylsyragrupper förestras fullständigt 30 eller partiellt med en biologiskt inert alkohol av den alifa-tiska, aralifatiska eller cykloalifatiska serien, förutsatt att alkoholen är en annan än metanol, och, om sä önskas, bildas salter av de fria karboxylgrupperna eller sä frigörs karboxylgrupper som är i saltform. 35
17. Förfarande enligt patentkrav 16 för framställning av hyaluronsyraestrar, kännetecknat av att forest- II 73 94767 ringsämnet omsätt i ett organiskt lösningsmedel med ett kva-ternärt ammoniumsalt av hyaluronsyra.
18. Förfarande enligt patentkrav 16 eller 17, k ä n n e - 5 tecknat av att säsom det ammoniumsalt som fungerar som utgängsämne används ett lägre tetra-alkylammoniumsalt.
19. Förfarande enligt patentkrav 16, kännetecknat av att hyaluronsyran behandlas med en önskad alkohol i närvaro 10 av katalysatorer eller med ett företringsmedel, som förmär ansluta den önskade alkoholresten, i närvaro av en oorganisk eller organisk bas.
20. Förfarande enligt patentkrav 16, kännetecknat 15 av att hyaluronsyrans metallsalt eller ett sait, som är bildat med en kvävehaltig organisk bas, behandlas med ett företringsmedel .
21. Förfarande enligt patentkrav 16, kännetecknat 20 av att hyaluronsyran behandlas med diazoalkan.
22. Förfarande enligt nägot av patentkraven 16 - 21, kännetecknat av att den förestrande alkoholkom-ponenten erhälles frän etyl-, propyl-, isopropyl-, n-propyl-, 25 isobutyl- eller t-butylalkohol, frän amyl-, pentyl-, hexyl-I eller oktylalkohol, frän etylenglykol, propylenglykol, buty-lenglykol, glycerin, tartronsyra, mjölksyra, glykolsyra, äppelsyra, vinsyra, citronsyra, aminoetanol, aminopropanol, n-aminobutanol eller frän ett dimetyl- eller dietylderivat av 30 aminoetanolens, aminopropanolens eller n-aminobutanolens aminofunktion, frän kolin, pyrroldinyl-etanol, piperidinyl-etanol, piperazinyl-etanol eller motsvarande n-propyl- eller n-butylalkoholderivat, frän monotioetylenglykol eller ett lägre alkylderivat av dess merkaptofunktionella grupp, eller 2Ξ frän en högre alifatisk alkohol, som utgörs av cetylalkohol, myrisylalkohol, sitronellol, geraniol, nerol, nerolidol, lina-lol, farnesol, fytol bensylalkohol, fenetylalkohol, cyklo- 74 94767 hexanol, cyklohexandil, 1,2,3-cyklohexantriol, 1,3,5-cyklo-hexantriol, inositol, karvomentol, mentol, piperitol, 1,4-eller 1,8-terpin, tujan, sabinol, hydraterad pinol, D- eller L-borneol eller D- eller L-isoborneol. 5
23. Förfarande enligt nägot av patentkraven 16 - 22, kännetecknat av att minst 5 % och högst 95 % av alla karboxylsyragrupperna i hyaluronsyran förestras. 10
24. Förfarande enligt nägot av patentkraven 16 - 23, kännetecknat av att 50 - 80 % av hyaluronsyrans karboxylgrupper förestras.
25. Förfarande enligt nägot av patentkraven 16 - 24, 15 kännetecknat av att de erhällna partiella estrarna överförs tili sinä salter, som är härledda frän alkalimetaller eller alkaliska jordartsmetaller, magnesium eller aluminium.
26. Förfarande enligt nägot av patentkraven 16 - 24, 20 kännetecknat av att de erhällna partiella estrarna överförs tili sinä salter, som är härledda frän ammonium eller alifatiska, aralifatiska, cykloalifatiska eller heterocykliska aminer. 23
27. Förfarande enligt nägot av patentkraven 16 - 22, kännetecknat av att säsom utgängsämne används en hyaluronsyrafraktion med en medelmolekylvikt pä ca 50.000 - 100.000, ca 500.000 - 730.000 eller ca 250.000 - 350.000. 30 II
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI912619A FI912619A0 (fi) | 1985-07-08 | 1991-05-31 | Hyaluronsyraestrar, foerfarande foer framstaellning daerav samt sanitets- och kirurgiska produkter innehaollande hyaluronsyraestrar. |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT4832285 | 1985-07-08 | ||
IT8548322A IT1214658B (it) | 1985-07-08 | 1985-07-08 | Esteri polisaccaridici e loro sali |
IT4820286 | 1986-06-30 | ||
IT48202/86A IT1203815B (it) | 1986-06-30 | 1986-06-30 | Esteri polisaccaridici e loro sali |
Publications (3)
Publication Number | Publication Date |
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FI901341A0 FI901341A0 (sv) | 1990-03-16 |
FI94767B true FI94767B (sv) | 1995-07-14 |
FI94767C FI94767C (sv) | 1995-10-25 |
Family
ID=26329289
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI862878A FI94766C (sv) | 1985-07-08 | 1986-07-08 | Förfarande för framställning av nya terapeutiskt användbara fullständiga och partiella hyaluronsyraestrar samt salter av dessa |
FI892711A FI892711A (fi) | 1985-07-08 | 1989-06-02 | Foerfarande foer framstaellning av sura polysackaridestrar innehaollande karboxylgrupper. |
FI892710A FI94778C (sv) | 1985-07-08 | 1989-06-02 | Förfarande för framställning av membraner eller fibrer bestående av hyaluronsyraestrar eller deras salter samt av hyaluronsyraestrar eller deras salter framställda, icke-terapeutiskt användbara fibrer och membraner |
FI901341A FI94767C (sv) | 1985-07-08 | 1990-03-16 | För icke-terapeutisk användning avsedda fullständiga och partiella estrar av hyaluronsyra |
FI912619A FI912619A0 (fi) | 1985-07-08 | 1991-05-31 | Hyaluronsyraestrar, foerfarande foer framstaellning daerav samt sanitets- och kirurgiska produkter innehaollande hyaluronsyraestrar. |
FI912618A FI912618A0 (fi) | 1985-07-08 | 1991-05-31 | Folier och fibrer av hyaluronsyraestrar eller salter daerav samt foerfarande foer framstaellning av dessa. |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI862878A FI94766C (sv) | 1985-07-08 | 1986-07-08 | Förfarande för framställning av nya terapeutiskt användbara fullständiga och partiella hyaluronsyraestrar samt salter av dessa |
FI892711A FI892711A (fi) | 1985-07-08 | 1989-06-02 | Foerfarande foer framstaellning av sura polysackaridestrar innehaollande karboxylgrupper. |
FI892710A FI94778C (sv) | 1985-07-08 | 1989-06-02 | Förfarande för framställning av membraner eller fibrer bestående av hyaluronsyraestrar eller deras salter samt av hyaluronsyraestrar eller deras salter framställda, icke-terapeutiskt användbara fibrer och membraner |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI912619A FI912619A0 (fi) | 1985-07-08 | 1991-05-31 | Hyaluronsyraestrar, foerfarande foer framstaellning daerav samt sanitets- och kirurgiska produkter innehaollande hyaluronsyraestrar. |
FI912618A FI912618A0 (fi) | 1985-07-08 | 1991-05-31 | Folier och fibrer av hyaluronsyraestrar eller salter daerav samt foerfarande foer framstaellning av dessa. |
Country Status (21)
Country | Link |
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US (3) | US4851521A (sv) |
EP (2) | EP0216453B1 (sv) |
JP (1) | JP2569012B2 (sv) |
KR (1) | KR870001901B1 (sv) |
AR (1) | AR242593A1 (sv) |
AT (2) | ATE227741T1 (sv) |
AU (1) | AU591501B2 (sv) |
CA (2) | CA1341276C (sv) |
DE (2) | DE3650776T2 (sv) |
DK (1) | DK175661B1 (sv) |
ES (1) | ES2001512A6 (sv) |
FI (6) | FI94766C (sv) |
HU (1) | HU201966B (sv) |
IE (1) | IE81120B1 (sv) |
IL (1) | IL79362A (sv) |
IN (1) | IN165582B (sv) |
NO (2) | NO175716C (sv) |
NZ (2) | NZ233045A (sv) |
PH (1) | PH25189A (sv) |
PT (1) | PT82941B (sv) |
SG (1) | SG90006A1 (sv) |
Families Citing this family (348)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
US5202431A (en) * | 1985-07-08 | 1993-04-13 | Fidia, S.P.A. | Partial esters of hyaluronic acid |
AU600257B2 (en) * | 1986-03-21 | 1990-08-09 | International Pharmaceutical Products, Inc. | Non-inflammatory hyaluronic acid fraction and process for preparing it |
IT1203814B (it) * | 1986-06-30 | 1989-02-23 | Fidia Farmaceutici | Esteri dell'acido alginico |
US5264422A (en) * | 1986-06-30 | 1993-11-23 | Fidia S.P.A. | Esters of alginic acid with steroidal alcohols |
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
IT1198449B (it) * | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
IT1219587B (it) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
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- 1986-07-07 DK DK198603236A patent/DK175661B1/da not_active IP Right Cessation
- 1986-07-07 SG SG9605757A patent/SG90006A1/en unknown
- 1986-07-07 EP EP86305233A patent/EP0216453B1/en not_active Expired - Lifetime
- 1986-07-07 AT AT95202284T patent/ATE227741T1/de not_active IP Right Cessation
- 1986-07-07 EP EP95202284A patent/EP0696598B1/en not_active Expired - Lifetime
- 1986-07-07 DE DE3650776T patent/DE3650776T2/de not_active Expired - Lifetime
- 1986-07-07 AT AT86305233T patent/ATE135713T1/de not_active IP Right Cessation
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- 1986-07-07 NO NO862734A patent/NO175716C/no not_active IP Right Cessation
- 1986-07-08 HU HU862845A patent/HU201966B/hu unknown
- 1986-07-08 PH PH33990A patent/PH25189A/en unknown
- 1986-07-08 IL IL7936286A patent/IL79362A/en not_active IP Right Cessation
- 1986-07-08 ES ES8601101A patent/ES2001512A6/es not_active Expired
- 1986-07-08 AR AR86304466A patent/AR242593A1/es active
- 1986-07-08 CA CA000513350A patent/CA1341276C/en not_active Expired - Lifetime
- 1986-07-08 NZ NZ233045A patent/NZ233045A/en unknown
- 1986-07-08 AU AU59836/86A patent/AU591501B2/en not_active Expired
- 1986-07-08 KR KR1019860005509A patent/KR870001901B1/ko not_active IP Right Cessation
- 1986-07-08 NZ NZ216786A patent/NZ216786A/en unknown
- 1986-07-08 PT PT82941A patent/PT82941B/pt unknown
- 1986-07-08 FI FI862878A patent/FI94766C/sv not_active IP Right Cessation
- 1986-07-08 JP JP61161769A patent/JP2569012B2/ja not_active Expired - Lifetime
- 1986-07-08 IN IN505/CAL/86A patent/IN165582B/en unknown
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1989
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1990
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1991
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1992
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