FI94778B - Förfarande för framställning av membraner eller fibrer bestående av hyaluronsyraestrar eller deras salter samt av hyaluronsyraestrar eller deras salter framställda, icke-terapeutiskt användbara fibrer och membraner - Google Patents

Förfarande för framställning av membraner eller fibrer bestående av hyaluronsyraestrar eller deras salter samt av hyaluronsyraestrar eller deras salter framställda, icke-terapeutiskt användbara fibrer och membraner Download PDF

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Publication number
FI94778B
FI94778B FI892710A FI892710A FI94778B FI 94778 B FI94778 B FI 94778B FI 892710 A FI892710 A FI 892710A FI 892710 A FI892710 A FI 892710A FI 94778 B FI94778 B FI 94778B
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FI
Finland
Prior art keywords
hyaluronic acid
ester
esters
groups
alcohols
Prior art date
Application number
FI892710A
Other languages
English (en)
Finnish (fi)
Other versions
FI892710A0 (sv
FI94778C (sv
FI892710A (sv
Inventor
Valle Francesco Della
Aurelio Romeo
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT8548322A external-priority patent/IT1214658B/it
Priority claimed from IT48202/86A external-priority patent/IT1203815B/it
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of FI892710A0 publication Critical patent/FI892710A0/sv
Publication of FI892710A publication Critical patent/FI892710A/sv
Priority to FI912618A priority Critical patent/FI912618A0/fi
Application granted granted Critical
Publication of FI94778B publication Critical patent/FI94778B/sv
Publication of FI94778C publication Critical patent/FI94778C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Claims (8)

1. Förfarande för framställning av folier eller fibrer bestäende av hyaluronsyraestrar eller salter därav, kännetecknat av att en fullständig eller partiell ester av hyaluronsyra och alkoholer av den alifatiska eller den aralifatiska serien loses i ett organiskt lösningsmedel och lösningen bringas i foiie- respektive fiberform, och sedan avlägsnas det organiska lösningsmedlet genom behandling med ett annat lämpligt organiskt eller vattenhaltigt lösningsmedel, som är lösligt i det första lösningsmedlet.
2. Förfarande enligt patentkrav 1, kännetecknat av att säsom lösningsmedel används dimetylsulfoxid.
3. Förfarande för framställning av folier eller fibrer bestäende av hyaluronsyraestrar eller salter därav, kännetecknat av att en fullständig eller partiell ester av hyaluronsyra och alkoholer av den alifatiska eller aralifatiska serien loses i ett organiskt lösningsmedel, lösningen bringas i folie- respektive fiberform, och sedan avlägsnas det organiska lösningsmedlet genom behandling med elström eller en lämpligt upphettad inert gas.
4. Förfarande enligt patentkrav 3, kännetecknat ,» av att säsom lösningsmedel används hexafluorisopropanol.
5. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att folierna eller fibrerna fram-ställs av estrar av den alifatiska serien, varvid alkoholerna av den alifatiska serien uppvisar högst 12 kolatomer och de är osubstituerade eller substituerade med en eller tvä funk-tionella grupper, vilka är valda bland en grupp som bestär av amino-, hydroxi-, merkapto-, aldehyd-, keto-, karboxi-, vätekarbyl- och divätekarbylaminogrupper, eter-, ester-, tioeter-, tioester-, acetal-, ketal-, karbalkoxi-, karbamid- . och substituerade karbamidigrupper, varvid vätekarbylradika- 4β 94778 lerna har en eller tvä alkylgrupper som i dessa funktionellt modifierade grupper uppvisar högst 6 kolatomer och varvid kolatomkedjan i dylika alkoholer av den alifatiska serien kan uppvisa heteroatomer, som är syre, svavel eller kväve.
6. Förfarande enligt nägot av patentkraven 1-4, kännetecknatav att folierna eller fibrerna fram-ställs av estrar av den aralifatiska serien, varvid alkoholeina av den aralifatiska serien har minst en bensenrest och den alifatiska kedjan har högst 4 kolatomer och bensenresten säsom substituenter uppvisar 1-3 metyl- eller hydroxigrup-per eller halogenatomer och den alifatiska kedjan säsom substituenter kan ha en eller tvä funktionella grupper, vilka är valda bland en grupp bestäende av fria aminogrupper, mono-eller dietylgrupper eller pyrrolidin- eller piperidingrupper.
7. Förfarande enligt nägot av de föregäende patentkraven, kännetecknatav att för framställning av folierna eller fibrerna används ett eller flera av följande ämnen: hyaluronsyrans partiella propylester, vars karboxylgrupper tili 50 % är i esterform och tili 50 % i formen av ett nat-riumsalt, hyaluronsyrans partiella isopropylester, vars karboxylgrupper ♦ · tili 50 % är i esterform och tili 50 % i formen av ett nat-riumsalt, hyaluronsyrans partiella propylester, vars karboxylgrupper tili 85 % är i esterform och tili 15 % i formen av ett nat-riumsalt, hyaluronsyrans partiella etylester, vars karboxylgrupper tili 75 % är i esterform och tili 25 % i formen av ett natrium-sait , hyaluronsyrans partiella metylester, vars karboxylgrupper 49 94778 till 75 % är i esterform och till 25 % i formen av ett nat-riumsalt, hyaluronsyrans fullständiga metylester, hyaluronsyrans fullständiga etylester, hyaluronsyrans fullständiga propylester, hyaluronsyrans partiella butylester, vars karboxylgrupper till 50 % är i esterform och till 50 % i formen av ett nat-riumsalt, hyaluronsyrans partiella etoxikarbonylmetylester, vars karboxylgrupper till 75 % är i esterform och till 25 % i formen av ett natriumsalt, hyaluronsyrans fullständiga pentylester, » « - hyaluronsyrans fullständiga isopentylester, hyaluronsyrans fullständiga bensenester, hyaluronsyrans fullständiga fenyletylester, «
8. För sanitets- och kirurgiskt bruk avsedda folier och fibrer, vilka är ämnade för icke-terapeutisk användning, kännetecknade av att de innehäller fullständiga eller partiella estrar bildade av hyaluronsyra och alkoholer av den alifatiska eller den aralifatiska serien eller salter av dessa estrar bildade av oorganiska eller organiska syror.
FI892710A 1985-07-08 1989-06-02 Förfarande för framställning av membraner eller fibrer bestående av hyaluronsyraestrar eller deras salter samt av hyaluronsyraestrar eller deras salter framställda, icke-terapeutiskt användbara fibrer och membraner FI94778C (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI912618A FI912618A0 (fi) 1985-07-08 1991-05-31 Folier och fibrer av hyaluronsyraestrar eller salter daerav samt foerfarande foer framstaellning av dessa.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IT4832285 1985-07-08
IT8548322A IT1214658B (it) 1985-07-08 1985-07-08 Esteri polisaccaridici e loro sali
IT4820286 1986-06-30
IT48202/86A IT1203815B (it) 1986-06-30 1986-06-30 Esteri polisaccaridici e loro sali
FI862878A FI94766C (sv) 1985-07-08 1986-07-08 Förfarande för framställning av nya terapeutiskt användbara fullständiga och partiella hyaluronsyraestrar samt salter av dessa
FI862878 1986-07-08

Publications (4)

Publication Number Publication Date
FI892710A0 FI892710A0 (sv) 1989-06-02
FI892710A FI892710A (sv) 1989-06-02
FI94778B true FI94778B (sv) 1995-07-14
FI94778C FI94778C (sv) 1995-10-25

Family

ID=26329289

Family Applications (6)

Application Number Title Priority Date Filing Date
FI862878A FI94766C (sv) 1985-07-08 1986-07-08 Förfarande för framställning av nya terapeutiskt användbara fullständiga och partiella hyaluronsyraestrar samt salter av dessa
FI892711A FI892711A0 (fi) 1985-07-08 1989-06-02 Foerfarande foer framstaellning av sura polysackaridestrar innehaollande karboxylgrupper.
FI892710A FI94778C (sv) 1985-07-08 1989-06-02 Förfarande för framställning av membraner eller fibrer bestående av hyaluronsyraestrar eller deras salter samt av hyaluronsyraestrar eller deras salter framställda, icke-terapeutiskt användbara fibrer och membraner
FI901341A FI94767C (sv) 1985-07-08 1990-03-16 För icke-terapeutisk användning avsedda fullständiga och partiella estrar av hyaluronsyra
FI912618A FI912618A0 (fi) 1985-07-08 1991-05-31 Folier och fibrer av hyaluronsyraestrar eller salter daerav samt foerfarande foer framstaellning av dessa.
FI912619A FI912619A0 (fi) 1985-07-08 1991-05-31 Hyaluronsyraestrar, foerfarande foer framstaellning daerav samt sanitets- och kirurgiska produkter innehaollande hyaluronsyraestrar.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FI862878A FI94766C (sv) 1985-07-08 1986-07-08 Förfarande för framställning av nya terapeutiskt användbara fullständiga och partiella hyaluronsyraestrar samt salter av dessa
FI892711A FI892711A0 (fi) 1985-07-08 1989-06-02 Foerfarande foer framstaellning av sura polysackaridestrar innehaollande karboxylgrupper.

Family Applications After (3)

Application Number Title Priority Date Filing Date
FI901341A FI94767C (sv) 1985-07-08 1990-03-16 För icke-terapeutisk användning avsedda fullständiga och partiella estrar av hyaluronsyra
FI912618A FI912618A0 (fi) 1985-07-08 1991-05-31 Folier och fibrer av hyaluronsyraestrar eller salter daerav samt foerfarande foer framstaellning av dessa.
FI912619A FI912619A0 (fi) 1985-07-08 1991-05-31 Hyaluronsyraestrar, foerfarande foer framstaellning daerav samt sanitets- och kirurgiska produkter innehaollande hyaluronsyraestrar.

Country Status (21)

Country Link
US (3) US4851521A (sv)
EP (2) EP0696598B1 (sv)
JP (1) JP2569012B2 (sv)
KR (1) KR870001901B1 (sv)
AR (1) AR242593A1 (sv)
AT (2) ATE135713T1 (sv)
AU (1) AU591501B2 (sv)
CA (2) CA1341603C (sv)
DE (2) DE3650501T2 (sv)
DK (1) DK175661B1 (sv)
ES (1) ES2001512A6 (sv)
FI (6) FI94766C (sv)
HU (1) HU201966B (sv)
IE (1) IE81120B1 (sv)
IL (1) IL79362A (sv)
IN (1) IN165582B (sv)
NO (2) NO175716C (sv)
NZ (2) NZ216786A (sv)
PH (1) PH25189A (sv)
PT (1) PT82941B (sv)
SG (1) SG90006A1 (sv)

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GB8519416D0 (en) * 1985-08-01 1985-09-04 Unilever Plc Oligosaccharides
DE3684887D1 (de) * 1985-11-29 1992-05-21 Biomatrix Inc Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung.
US4696677A (en) * 1986-04-11 1987-09-29 Merck & Co., Inc. Quaternary ammonium salts of anionic gums
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico

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PT82941B (pt) 1988-05-27
FI94767C (sv) 1995-10-25
ES2001512A6 (es) 1988-06-01
IE81120B1 (en) 2000-03-22
IL79362A0 (en) 1986-10-31
FI862878A (sv) 1987-01-09
DE3650776D1 (de) 2002-12-19
SG90006A1 (en) 2002-07-23
NO862734D0 (no) 1986-07-07
FI892710A0 (sv) 1989-06-02
FI892711A (fi) 1989-06-02
EP0696598A1 (en) 1996-02-14
US4965353A (en) 1990-10-23
FI94766C (sv) 1995-10-25
HUT42512A (en) 1987-07-28
PT82941A (en) 1986-08-01
FI94766B (sv) 1995-07-14
NO910295L (no) 1987-01-09
FI912618A0 (fi) 1991-05-31
NZ233045A (en) 1992-05-26
FI862878A0 (sv) 1986-07-08
ATE227741T1 (de) 2002-11-15
DE3650776T2 (de) 2004-03-11
KR870001901B1 (ko) 1987-10-21
KR870001230A (ko) 1987-03-12
FI892711A0 (fi) 1989-06-02
ATE135713T1 (de) 1996-04-15
AU591501B2 (en) 1989-12-07
NO175716B (no) 1994-08-15
CA1341276C (en) 2001-07-31
JP2569012B2 (ja) 1997-01-08
HU201966B (en) 1991-01-28
DK323686D0 (da) 1986-07-07
US4851521A (en) 1989-07-25
DK175661B1 (da) 2005-01-10
DE3650501T2 (de) 1996-11-21
PH25189A (en) 1991-03-27
JPS6264802A (ja) 1987-03-23
NO910295D0 (no) 1991-01-25
EP0216453A3 (en) 1988-10-26
EP0216453A2 (en) 1987-04-01
AR242593A1 (es) 1993-04-30
FI94778C (sv) 1995-10-25
IE861813L (en) 1987-01-08
IN165582B (sv) 1989-11-25
NO862734L (no) 1987-01-09
FI912619A0 (fi) 1991-05-31
IL79362A (en) 1995-07-31
DE3650501D1 (de) 1996-04-25
FI892710A (sv) 1989-06-02
FI901341A0 (sv) 1990-03-16
US5336767A (en) 1994-08-09
EP0696598B1 (en) 2002-11-13
NZ216786A (en) 1992-05-26
FI94767B (sv) 1995-07-14
AU5983686A (en) 1987-02-26
DK323686A (da) 1987-01-09
CA1341603C (en) 2010-04-20
EP0216453B1 (en) 1996-03-20
NO175716C (no) 1994-11-23
NO305369B1 (no) 1999-05-18

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