JP6394916B2 - 乾燥止血組成物 - Google Patents
乾燥止血組成物 Download PDFInfo
- Publication number
- JP6394916B2 JP6394916B2 JP2015516467A JP2015516467A JP6394916B2 JP 6394916 B2 JP6394916 B2 JP 6394916B2 JP 2015516467 A JP2015516467 A JP 2015516467A JP 2015516467 A JP2015516467 A JP 2015516467A JP 6394916 B2 JP6394916 B2 JP 6394916B2
- Authority
- JP
- Japan
- Prior art keywords
- paste
- polyols
- dry composition
- composition
- dry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/081—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/082—X-rays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/087—Particle radiation, e.g. electron-beam, alpha or beta radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultra-violet radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/202—Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/204—Formaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/206—Ethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/208—Hydrogen peroxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0038—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Description
a.粉末状の生体適合性重合体、1種または複数のポリオール、および水性媒体を用意する工程、
b.生体適合性重合体、1種または複数のポリオール、および水性媒体を混合してペーストとする工程、および
c.ペーストを乾燥させる工程。
「生理活性作用剤」は、in vivoまたはin vitroで実証可能なある薬理作用(たいていは有益なものである)を提供する任意の作用剤、薬物、化合物、組成物、または混合物である。すなわち、ある作用剤がヒトまたは動物の身体で細胞組織と相互作用するまたは細胞組織に影響を及ぼすならば、それは生理活性であるとみなされる。本明細書中使用される場合、この用語はさらに、個体において局所的または全身的な作用をもたらす任意の生理学的または薬理学的活性物質を含む。生理活性作用剤は、タンパク質(酵素など)であってもよい。生理活性作用剤のさらなる例として、オリゴ糖、多糖、随意にグリコシル化されたペプチド、随意にグリコシル化されたポリペプチド、オリゴヌクレオチド、ポリヌクレオチド、脂質、脂肪酸、脂肪酸エステル、および二次代謝産物それぞれを含む、またはそれぞれのみからなる作用剤が挙げられるが、それらに限定されない。生理活性作用剤は、個体(ヒトまたは他の任意の動物など)の治療に関連して、予防、治療のいずれかとして用いることができる。
本発明は、適切な量の水性媒体が添加されると、止血手当に使用するのに適した実質的に均質なペーストを形成する、乾燥組成物に関する。このペーストは、液体成分が添加されると自然に形成される、すなわちこのペーストを形成するのに機械撹拌は不要である。
a.粉末状の生体適合性重合体、1種または複数のポリオール、および水性媒体を用意する工程、
b.生体適合性重合体、1種または複数のポリオール、および水性媒体を混合してペーストとする工程、および
c.ペーストを乾燥させる工程。
・ペーストを調製するのにかかる時間が短くなり、例えば出血をより早く止めることができる。
・作業工程が少なくなるので、調製中にペーストの滅菌が損なわれる危険性が低下する。
・ペースト調製が単純になるので、調製中に間違いを起こす危険性が低下する。
・最適な堅牢度のペーストが毎回得られる。
・溶液中では不安定な生理活性作用剤を乾燥前のペーストに添加することができ、したがって、そのような作用剤を本発明の乾燥組成物中に存在させることができる。例えば、トロンビンを乾燥前のペーストに添加することができ、そうすることで、時間がかかり間違いを起こしやすいトロンビン希釈工程を回避することができる。
本発明は、粉末状の生体適合性作用剤に関連し、この作用剤を用いてペーストを作る。次いで、ペーストを乾燥させて、止血および創傷治癒手当に使用するのに適した乾燥組成物を得る。
本発明の水性媒体は、当業者に既知の止血用途に適したペーストを調製するのに適していればどんな水性媒体でもよく、例えば水、生理食塩水、塩化カルシウム溶液、または緩衝化水性媒体が可能である。水は、WFI(輸液用水)であってもよい。ヒトまたは動物を対象として用いる予定の場合には再構築されたペースト生成物が等張性になるように、水性媒体を選択することが重要である。
本発明に従って、乾燥前の組成物に1種または複数のポリオールが添加される。1種または複数のポリオールは、水性媒体である液体(水など)を添加すると、どのような種類の機械混合または撹拌も用いることなく、自然に再構築されて止血目的に最適な堅牢度のペーストを形成する、乾燥組成物を得る上で役割を果たす。
本発明の1つの実施形態において、乾燥組成物は、1種または複数の生理活性作用剤を含む。生理活性作用剤がその生理活性を保持すること、すなわち生理活性作用剤が乾燥組成物の再構築後のペーストにおいて生理活性であることは、必須である。多くの生理活性作用剤が溶液中で不安定であり、特に酵素および他のタンパク質は、水が存在すると、分解してしまうか、その二次構造を失ってしまう可能性がある。
本発明の乾燥組成物は、以下:DMSO(ジメチルスルホキシド)、2−メチル−2,4−ペンタンジオール(MPD)のうち1種または複数、および/または以下の表に記載される化合物のうち1種または複数を、さらに含むことができる。
本発明の方法に従って、生体適合性重合体および1種または複数のポリオールを、適切な水性媒体と混合してペーストとする。混合は、当業者に既知の任意の適切なやり方で、例えば、内容物を手作業で混合すること、または電動混合装置(ハンドミキサー、キッチンミキサー、または業務用ミキサーなど)を用いることなどにより、行うことができる。
本発明のペーストの調製および乾燥中の収容には、当業者に既知の任意の適切な容器(バイアル、ジャー、チューブ、トレイ、カートリッジ、またはシリンジなど)を使用することができる。
1つの実施形態において、乾燥組成物は、シート状である、すなわち、実質的に平坦な組成物である。
本発明に従って、ペーストを乾燥させて、乾燥組成物とする。ペーストは、当業者に既知の任意の適切な方法で乾燥させることができる。適切な乾燥方法の例として、凍結乾燥および噴霧乾燥が挙げられる。
1つの実施形態において、乾燥組成物は、例えばシリンジまたは他の収容ユニットに収容された状態で、さらに外側包装材に収容され、それにより、その乾燥製品を使用時まで滅菌に保つことができる。そうすると、使用者は、外側包装を取り去って乾燥組成物を滅菌場に移すことができる。そこで、適切な量の水性媒体を加えることができ、添加されると、すぐに使えるペーストが、機械的な振盪、撹拌、または混合をまったく必要とせずに、数秒以内に自然に形成される。
本発明の乾燥組成物は、好ましくは、滅菌されている。当該分野で既知の任意の適切な滅菌技法を利用できる。滅菌は、好ましくは、包装工程後、すなわち乾燥組成物が外側包装材に収容された後に行われる。したがって、好適な実施形態において、滅菌は、最終滅菌である。
本発明はさらに、乾燥組成物から得られるペーストの、止血および/または創傷治癒を促進するための使用に関する。
本発明はさらに、本発明の乾燥組成物および乾燥組成物の量に合致した量の水性媒体を含み、水性媒体が添加されると、止血ペーストとして用いるのに適した堅牢度の止血ペーストが自然に、すなわち数秒以内に形成される、止血キットに関する。
a)本発明の方法により得られた乾燥組成物の入った容器、
b)水性媒体の入った容器、および
c)任意選択の外側包装材。
1.以下の工程を逐次含む、乾燥止血組成物の調製法:
a.粉末状の止血剤、1種または複数のポリオール、および水性媒体を用意する工程、
b.止血剤、1種または複数のポリオール、および水性媒体を混合してペーストとする工程、および
c.ペーストを乾燥させる工程。
a.約2%〜約40%の1種または複数のポリオール、
b.約10%〜約60%の止血剤、および
c.約50%〜約90%の水。
a.約5%〜約20%の1種または複数のポリオール、
b.約15%〜約25%の止血剤、および
c.約60%〜約80%の水。
a.約10%〜約60%の1種または複数のポリオール、
b.約40%〜約80%の止血剤、および
c.約0.1%〜約5%の水。
a.約20%〜約50%の1種または複数のポリオール、
b.約50%〜約80%の止血剤、および
c.約0.1%〜約2%の水。
a.項目1〜23のいずれか1つに記載の方法により得られる乾燥止血組成物、または項目24〜34のいずれか1つに記載の乾燥止血組成物、
b.容器、
c.水性媒体、および
d.任意選択の外側包装材。
材料
ゼラチン粉末50g(架橋ゼラチンスポンジを粉砕したもの)
緩衝液200ml
ポリオール
50%塩化ベンザルコニウム(BAC)
0.9%生理食塩水
凍結乾燥機:Leybold−Heraus、Lyovac GT2またはChrist Alpha 1−4 LSC
ミキサー:Kenwood、Major KM616
緩衝液:
BAC(50%)2.0g±0.1gを青キャップの付いた250mLビンに入れる
BACに生理食塩水98.0g±0.5gを加える
磁気撹拌子で2分間混合する−これをBAC原液とする
グリセロール123.0g±0.5gを2000mLメスフラスコに入れる
BAC原液10g±0.5gを加える
2000mLの印まで生理食塩水を加える
フラスコに栓をして、数回上下をひっくり返す
磁気撹拌子で5±1分間混合する
ミキサーで撹拌しながら、緩衝液200mlにポリオールxgを溶解させる。溶解したポリオールにゼラチン粉末50gを加え、均質なペーストが得られるまで、約5分間、混合する。ペーストの混合は、室温(約20℃)で行った。
得られるペーストを、10mlの使い捨てプラスティックシリンジに充填し(シリンジ1本あたり5.5ml)、最低でも4時間−30℃下に置く。凍結したペーストを凍結乾燥機に移し、乾燥するまで15時間凍結乾燥させる。
各シリンジに液体8mlを加える、すなわち、凍結乾燥プロセス中に組成物から除去された量の水を加えることで、乾燥組成物を再構築させる。機械的な混合または撹拌は一切行わなかった。水を乾燥組成物にただ加えただけであり、ペーストが再形成されるまで組成物には手を触れずに放置した。
様々な配合について、再構築にかかる時間、すなわちどのような種類の機械的振盪撹拌もせずに、止血目的に適したペーストが自然に形成されるのに必要な時間を調べた。
配合例5は、5秒で自然に再構築された。配合例5の内容を、ペースト(湿潤下)および乾燥組成物(乾燥下)のそれぞれについて、以下の表に明記する。
実施例1に記載の方法に従って、ペーストを作り、乾燥させ、再構築させた。ペーストの内容を以下の表に示す。
実施例1に記載の方法に従って、ペーストを作り、乾燥させ、再構築させたが、ただし実施例1の緩衝液の代わりに水を用いた。ペーストの内容を以下の表に示す。
実施例1に記載の方法に従って、ペーストを作り、乾燥させ、再構築させた。ペーストの内容を以下の表に示す。
実施例1の配合例5のペーストに、トロンビンを、2500IU/生成物(8ml)の理論濃度で含ませた。ペーストは、実施例1に記載のとおり、室温(約20℃)で作り混合した。
基本的に実施例1に記載のとおり、様々なポリオールを含むペーストを作り、乾燥させ、再構築させたが、ただし実施例1の緩衝液の代わりにBACを含むH2Oを用いた。ペーストの内容を以下の表に示す。
Claims (18)
- 以下の工程:
a.粉末状の架橋した生体適合性重合体、1種または複数の糖アルコール、および水性媒体を用意する工程、
b.該生体適合性重合体、該1種または複数の糖アルコール、および該水性媒体を混合してペーストとする工程、および
c.該ペーストを凍結乾燥させる工程、
を逐次含む、止血および創傷治癒に用いられる乾燥組成物の調製方法であって、
該乾燥組成物は、10%w/w〜60%w/wの一種または複数の糖アルコールを含む、方法。 - 前記ペーストは、乾燥前に、3%w/w〜20%w/wの1種または複数の糖アルコールを含む、請求項1に記載の方法。
- 前記生体適合性重合体はゼラチンである、請求項1または2に記載の方法。
- 前記ゼラチンは架橋ゼラチンスポンジから得られる、請求項3に記載の方法。
- 前記ペーストは、凍結乾燥前に、以下:
a.5%w/w〜20%w/wの1種または複数の糖アルコール、
b.15%w/w〜25%w/wの生体適合性重合体、および
c.60%w/w〜80%w/wの水、
を含む、請求項1から4のいずれか1項に記載の方法。 - 前記乾燥組成物は、5%w/w未満の水を含む、請求項1から5のいずれか1項に記載の方法。
- 前記1種または複数の糖アルコールは、グリコール、グリセロール、エリスリトール、トレイトール、アラビトール、キシリトール、リビトール、マンニトール、ソルビトール、ズルシトール、フシトール、イジトール、イノシトール、ボレミトール、イソマルト、マルチトール、ラクチトール、およびポリグリシトールからなる群より選択される、請求項1に記載の方法。
- 前記1種または複数の糖アルコールは、グリコール、エリスリトール、トレイトール、アラビトール、キシリトール、リビトール、マンニトール、ソルビトール、ズルシトール、フシトール、イジトール、イノシトール、ボレミトール、イソマルト、マルチトール、ラクチトール、およびポリグリシトールからなる群より選択される、請求項1に記載の方法。
- 前記1種または複数の糖アルコールは、マンニトールおよび前記組成物の任意選択からなる1種または複数の追加の糖アルコールである、請求項1から8のいずれか1項に記載の方法。
- 前記乾燥組成物はさらに、止血、あるいは創傷、骨、腱、および/または組織の治癒を刺激する1種または複数の生理活性作用剤を含む、請求項1から9のいずれか1項に記載の方法。
- 前記生理活性作用剤はトロンビンである、請求項10に記載の方法。
- 前記水性媒体は、水、生理食塩水、塩化カルシウム溶液、および緩衝化水性媒体からなる群より選択される、請求項1から11のいずれか1項に記載の方法。
- 前記方法は、前記乾燥組成物を外側包装材に入れるさらなる工程を含む、請求項1から12のいずれか1項に記載の方法。
- 前記方法は、前記乾燥組成物を滅菌するさらなる工程を含む、請求項1から13のいずれか1項に記載の方法。
- 前記ペーストは、流動性止血組成物を分配するのに用いられるシリンジまたは他の既知のアプリケーターに充填される、請求項1から14のいずれか1項に記載の方法。
- 前記乾燥組成物は、20%w/w〜50%w/wの1種または複数の糖アルコールを含む、請求項1から15のいずれか1項に記載の方法。
- 以下:
a.請求項1から16のいずれか1項に記載の方法により得られる乾燥組成物、および
b.水性媒体を該乾燥組成物に添加する工程
によってペーストを調製する工程を含む、止血および創傷治癒に用いられる乾燥組成物を再構築させる方法。 - 前記乾燥組成物は、シリンジに存在する、請求項17に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261658586P | 2012-06-12 | 2012-06-12 | |
DKPA201270319 | 2012-06-12 | ||
DKPA201270319 | 2012-06-12 | ||
US61/658,586 | 2012-06-12 | ||
PCT/DK2013/050191 WO2013185776A1 (en) | 2012-06-12 | 2013-06-12 | Dry haemostatic composition |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015519152A JP2015519152A (ja) | 2015-07-09 |
JP6394916B2 true JP6394916B2 (ja) | 2018-09-26 |
Family
ID=49757603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015516467A Active JP6394916B2 (ja) | 2012-06-12 | 2013-06-12 | 乾燥止血組成物 |
Country Status (11)
Country | Link |
---|---|
US (3) | US9265858B2 (ja) |
EP (2) | EP2825216B1 (ja) |
JP (1) | JP6394916B2 (ja) |
CN (1) | CN104349797B (ja) |
AU (1) | AU2013275758B2 (ja) |
BR (1) | BR112014030962A2 (ja) |
CA (1) | CA2874290C (ja) |
HK (1) | HK1205008A1 (ja) |
IN (1) | IN2014DN10106A (ja) |
RU (1) | RU2636240C2 (ja) |
WO (1) | WO2013185776A1 (ja) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10500309B2 (en) * | 2007-10-05 | 2019-12-10 | Cook Biotech Incorporated | Absorbable adhesives and their formulation for use in medical applications |
US8642831B2 (en) | 2008-02-29 | 2014-02-04 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
WO2013131520A2 (en) | 2012-03-06 | 2013-09-12 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
RU2636240C2 (ru) | 2012-06-12 | 2017-11-21 | Ферросан Медикал Дивайсиз А/С | Сухая гемостатическая композиция |
JP6390873B2 (ja) | 2013-06-21 | 2018-09-19 | フェッローサン メディカル ディバイス エー/エス | 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ |
RU2678592C1 (ru) | 2013-12-11 | 2019-01-30 | Ферросан Медикал Дивайсиз А/С | Сухая композиция, содержащая компонент, улучшающий экструзию |
WO2016022807A1 (en) | 2014-08-08 | 2016-02-11 | The Brigham And Women's Hospital, Inc. | Elastic biopolymer and use as a tissue adhesive |
BR112017007466B1 (pt) * | 2014-10-13 | 2021-03-02 | Ferrosan Medical Devices A/S | método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca |
JP6747650B2 (ja) | 2014-12-24 | 2020-08-26 | フェロサン メディカル デバイシーズ エイ/エス | 第1の物質と第2の物質を保持し混合するためのシリンジ |
EP3270985B1 (en) | 2015-03-19 | 2021-02-24 | The Brigham and Women's Hospital, Inc. | Polypeptide compositions and methods of using the same |
US10918796B2 (en) | 2015-07-03 | 2021-02-16 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
US10751444B2 (en) | 2015-08-07 | 2020-08-25 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
US10660945B2 (en) | 2015-08-07 | 2020-05-26 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
EP3413940A4 (en) | 2016-02-08 | 2020-07-15 | The Brigham and Women's Hospital, Inc. | BIOADHESIVE FOR CORNEAL REPAIR |
KR20180027126A (ko) * | 2016-09-06 | 2018-03-14 | (주)한국비엠아이 | 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물 |
IL311121A (en) * | 2017-03-27 | 2024-04-01 | Regeneron Pharma | Sterilization method |
US10507165B2 (en) * | 2017-05-31 | 2019-12-17 | Adienne Pharma & Biotech Sa | Multi chamber flexible bag and methods of using same |
US11679177B2 (en) | 2017-08-08 | 2023-06-20 | Baxter International Inc. | Polymeric compositions, delivery devices, and methods |
KR20210008479A (ko) * | 2018-05-09 | 2021-01-22 | 훼로산 메디칼 디바이스 에이/에스 | 지혈 조성물을 제조하는 방법 |
CN110732037B (zh) * | 2018-07-20 | 2023-05-26 | 广州倍绣生物技术有限公司 | 止血糊剂及其制备方法 |
IL261190A (en) * | 2018-08-16 | 2019-01-31 | Omrix Biopharmaceuticals Ltd | Stable liquid preparations of thrombin |
CN111346256A (zh) * | 2018-12-22 | 2020-06-30 | 江苏昌吉永生物科技股份有限公司 | 一种医用止血愈合海绵的冻干成型优化方法 |
US20230001048A1 (en) * | 2019-12-25 | 2023-01-05 | Guangzhou Bioseal Biotech Co., Ltd. | Hemostatic paste and uses thereof |
CN115025274B (zh) * | 2021-03-04 | 2023-03-17 | 海宁侏罗纪生物科技有限公司 | 一种医用组织粘合胶及其制备方法 |
EP4312803A1 (en) | 2021-03-31 | 2024-02-07 | Ethicon, Inc | Systems, devices and methods for dispensing flowable hemostats that incorporate safety mechanisms for preventing air embolisms |
CN113144277B (zh) * | 2021-04-13 | 2022-06-14 | 武汉理工大学 | 一种可注射流体明胶及其制备方法和应用 |
CN117750985A (zh) | 2021-04-14 | 2024-03-22 | 广州倍绣生物技术有限公司 | 可流动的止血糊剂 |
WO2023056588A1 (en) | 2021-10-08 | 2023-04-13 | Guangzhou Bioseal Biotech Co., Ltd. | Systems, devices and methods of using hydraulic forces for delivering flowable, therapeutic compositions to surgical sites |
Family Cites Families (519)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2899362A (en) | 1959-08-11 | Hemostatic sponges and method of | ||
US2465357A (en) | 1944-08-14 | 1949-03-29 | Upjohn Co | Therapeutic sponge and method of making |
US2465860A (en) | 1945-10-13 | 1949-03-29 | Standard Manifold Company Inc | Carbon holder |
GB648619A (en) | 1947-03-19 | 1951-01-10 | Ferrosan As | Process of producing sponges of gelatine and the like proteins |
US2507244A (en) | 1947-04-14 | 1950-05-09 | Upjohn Co | Surgical gelatin dusting powder and process for preparing same |
CH264752A (de) | 1947-06-03 | 1949-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Trägern für Arzneimittel. |
GB697603A (en) | 1948-10-06 | 1953-09-23 | Sydney Arthur Gladstone | Improvements in or relating to method of and devices for obtaining tissue from a tumour carried by a patient |
US3089815A (en) | 1951-10-11 | 1963-05-14 | Lieb Hans | Injectable pharmaceutical preparation, and a method of making same |
US3224434A (en) | 1962-11-06 | 1965-12-21 | Waldemar Medical Res Foundatio | Cell collector |
GB1037937A (en) | 1963-06-26 | 1966-08-03 | Colgate Palmolive Co | Pressurized dispensing containers |
US3869539A (en) | 1966-12-01 | 1975-03-04 | Ferrosan As | Preparations containing fat-soluble vitamins in dry, particulate, free-flowing form dispersible in cold water and method of producing such preparations |
US3514518A (en) | 1967-12-19 | 1970-05-26 | Pierre Charier Vadrot | Process for preparation of gelatinous material from animal collagen |
US3470109A (en) | 1968-01-31 | 1969-09-30 | Aloe Creme Lab Inc | Method of making reconstitutable aloe gel in crystalline form |
US3608593A (en) | 1970-02-27 | 1971-09-28 | Lilly Co Eli | Method of filling powders into containers |
US3678933A (en) | 1970-07-17 | 1972-07-25 | Moore Perk Corp | Surgical sponge or bandage |
US3892876A (en) | 1971-11-30 | 1975-07-01 | Leiner & Sons Wales Limited P | Process of preparing freeze-dried gelatin |
FR2167197B1 (fr) | 1972-01-10 | 1974-06-21 | Pont Brule Sa | Compositions ameliorees contenant de la gelatine |
US3815580A (en) | 1972-08-31 | 1974-06-11 | C Oster | Apparatus for and method of collecting and preserving cytologic samples |
US3946732A (en) | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
SE420565B (sv) | 1974-06-06 | 1981-10-19 | Pharmacia Ab | Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel |
US4002173A (en) | 1974-07-23 | 1977-01-11 | International Paper Company | Diester crosslinked polyglucan hydrogels and reticulated sponges thereof |
US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
US4013078A (en) | 1974-11-25 | 1977-03-22 | Feild James Rodney | Intervertebral protector means |
JPS5823410B2 (ja) | 1974-11-12 | 1983-05-14 | 株式会社クラレ | ヒドロゲルヨウキザイ |
JPS51125156U (ja) | 1975-03-31 | 1976-10-09 | ||
US4006220A (en) | 1975-06-04 | 1977-02-01 | Gottlieb Sheldon K | Compositions and methods useful for repairing depressed cutaneous scars |
US4280954A (en) | 1975-07-15 | 1981-07-28 | Massachusetts Institute Of Technology | Crosslinked collagen-mucopolysaccharide composite materials |
US4160022A (en) | 1975-09-15 | 1979-07-03 | Colgate Palmolive Company | Toothpaste |
US4098728A (en) | 1976-01-02 | 1978-07-04 | Solomon Rosenblatt | Medical surgical sponge and method of making same |
US4150744A (en) | 1976-02-27 | 1979-04-24 | Smith & Nephew Pharmaceuticals Ltd. | Packaging |
JPS5329936A (en) | 1976-08-31 | 1978-03-20 | Takeda Chem Ind Ltd | Antibiotic composition |
SE430609B (sv) | 1976-12-21 | 1983-11-28 | Sca Development Ab | Sett att ur cellulosaderivat framstella absorberande material |
DE2816130A1 (de) | 1977-06-10 | 1978-12-21 | Ato Chimie | Verfahren und vorrichtung zur messung des haftvermoegens eines haftklebers |
US4164559A (en) | 1977-09-21 | 1979-08-14 | Cornell Research Foundation, Inc. | Collagen drug delivery device |
US4208439A (en) | 1977-10-25 | 1980-06-17 | Societe D'assistance Technique Pour Produits Nestle S.A. | Preparation of pasta |
GB1584080A (en) | 1977-12-05 | 1981-02-04 | Ethicon Inc | Absorbable hemostatic composition |
DE2843963A1 (de) | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
US4265233A (en) | 1978-04-12 | 1981-05-05 | Unitika Ltd. | Material for wound healing |
US4179400A (en) | 1978-05-09 | 1979-12-18 | W. R. Grace & Co. | Process for preparing catalytic solutions of sulfonium salts |
AT359652B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
AT359653B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
DE3036033A1 (de) | 1980-09-24 | 1982-05-06 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung |
US4300494A (en) | 1979-09-26 | 1981-11-17 | Shell Oil Company | Thermal insulated intake ports |
DE2943520C2 (de) | 1979-10-27 | 1982-05-19 | Fa. Carl Freudenberg, 6940 Weinheim | Verfahren zur Herstellung von Kollagenschwamm für medizinische oder kosmetische Zwecke |
US4292972A (en) | 1980-07-09 | 1981-10-06 | E. R. Squibb & Sons, Inc. | Lyophilized hydrocolloio foam |
DE3105624A1 (de) | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
DE3267499D1 (en) | 1981-03-18 | 1986-01-02 | Fujirebio Kk | Support material for use in serological testing and process for the production thereof |
BR8207913A (pt) | 1981-10-06 | 1983-09-13 | Rocep Lusol Holdings | Aparelho aplicador pressurizado |
DE3146841A1 (de) | 1981-11-26 | 1983-06-01 | Beiersdorf Ag, 2000 Hamburg | "neue wundbehandlungsmittel" |
US4424208A (en) | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
EP0086627B1 (en) | 1982-02-12 | 1985-08-28 | Unitika Ltd. | Anti-cancer device |
US4482386A (en) | 1982-03-26 | 1984-11-13 | Warner-Lambert Company | Method of conditioning a water swellable hydrocolloid |
US4543332A (en) | 1982-03-29 | 1985-09-24 | Miles Laboratories, Inc. | Method for the preparation of spherical microorganism cell aggregates |
JPS5928472A (ja) | 1982-08-09 | 1984-02-15 | Koken:Kk | 細胞培養用基質およびこの基質を用いた細胞培養・分離法 |
EP0106648B1 (en) | 1982-10-16 | 1988-05-18 | Johnsen & Jorgensen Jaypak Limited | Bag apparatus |
US4540410A (en) | 1982-11-16 | 1985-09-10 | Serono Pharmaceutical Partners | Lyophilized compositions, preparation and use thereof |
JPS59113889A (ja) | 1982-12-17 | 1984-06-30 | Sumitomo Chem Co Ltd | 固定化酵素もしくは固定化微生物菌体の製造方法 |
JPS59113889U (ja) | 1983-01-24 | 1984-08-01 | 西部電機工業株式会社 | カウンタ式エンコ−ダ |
US4492305A (en) | 1983-07-08 | 1985-01-08 | Marion Laboratories, Inc. | Package for collecting cultures |
DE3466702D1 (en) | 1983-07-14 | 1987-11-12 | Hitachi Chemical Co Ltd | Gelatin spherical gels and production thereof |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
JPS60110669A (ja) | 1983-11-12 | 1985-06-17 | 株式会社林原生物化学研究所 | 圧出容器とその製造方法 |
US4515637A (en) | 1983-11-16 | 1985-05-07 | Seton Company | Collagen-thrombin compositions |
US4522302A (en) | 1984-03-05 | 1985-06-11 | Sterling Drug Inc. | Pre-sterilized medical procedure kit packages |
AT389815B (de) | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
US4600574A (en) | 1984-03-21 | 1986-07-15 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of producing a tissue adhesive |
US4837285A (en) | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
ZA851661B (en) | 1984-03-29 | 1986-10-29 | Minnesota Mining & Mfg | Sorbent sheet material |
JPS60214728A (ja) | 1984-04-06 | 1985-10-28 | Unitika Ltd | 生理活性物質徐放性材料 |
SE456346B (sv) | 1984-07-23 | 1988-09-26 | Pharmacia Ab | Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning |
JPS6144825A (ja) | 1984-08-09 | 1986-03-04 | Unitika Ltd | 止血剤 |
GB8422950D0 (en) | 1984-09-11 | 1984-10-17 | Warne K J | Hydrogel |
JPS61122222A (ja) | 1984-11-19 | 1986-06-10 | Koken:Kk | コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤 |
US5165938A (en) | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
US5178883A (en) | 1984-11-29 | 1993-01-12 | Regents Of The University Of Minnesota | Method for promoting hair growth |
US4600533A (en) | 1984-12-24 | 1986-07-15 | Collagen Corporation | Collagen membranes for medical use |
JPS61209590A (ja) | 1985-03-13 | 1986-09-17 | Asama Kasei Kk | 新規な固定化細胞およびそれを利用する醗酵生産法 |
US4997753A (en) | 1985-04-04 | 1991-03-05 | Verax Corporation | Weighted collagen microsponge for immobilizing bioactive material |
US4863856A (en) | 1985-04-04 | 1989-09-05 | Verax Corporation | Weighted collagen microsponge for immobilizing bioactive materials |
US4861714A (en) | 1985-04-04 | 1989-08-29 | Verax Corporation | Weighted collagen microsponge for immobilizing bioactive material |
AT382783B (de) | 1985-06-20 | 1987-04-10 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
US5112750A (en) | 1985-06-25 | 1992-05-12 | Asama Chemical Co., Ltd. | Immobilized cells and culture method utilizing the same |
US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
US5007916A (en) | 1985-08-22 | 1991-04-16 | Johnson & Johnson Medical, Inc. | Method and material for prevention of surgical adhesions |
JPS6270318A (ja) | 1985-09-25 | 1987-03-31 | Nippon Kayaku Co Ltd | 止血及び創傷保護剤 |
JPS6270318U (ja) | 1985-10-22 | 1987-05-02 | ||
US4696812A (en) | 1985-10-28 | 1987-09-29 | Warner-Lambert Company | Thrombin preparations |
US5180583A (en) | 1985-11-26 | 1993-01-19 | Hedner Ulla K E | Method for the treatment of bleeding disorders |
US20020192271A1 (en) | 1985-11-26 | 2002-12-19 | Hedner Ulla Karin Elisabeth | Method for causing local hemostasis and hemostatic composition for local hemostasis |
IE59361B1 (en) | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
JPS62221357A (ja) | 1986-03-20 | 1987-09-29 | ジエクス株式会社 | 生物体表面への塗布剤 |
IL78826A (en) | 1986-05-19 | 1991-05-12 | Yissum Res Dev Co | Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom |
US4946870A (en) | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
US5300494A (en) | 1986-06-06 | 1994-04-05 | Union Carbide Chemicals & Plastics Technology Corporation | Delivery systems for quaternary and related compounds |
US4832686A (en) | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
US4803075A (en) | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
US4702737A (en) | 1986-07-14 | 1987-10-27 | Pizzino Joanne L | Dual dose syringe |
US4743229A (en) | 1986-09-29 | 1988-05-10 | Collagen Corporation | Collagen/mineral mixing device and method |
US4965203A (en) | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
US4885161A (en) | 1987-03-11 | 1989-12-05 | Medi-Tech International Corporation | Wound dressings in gelled paste form |
CA1305069C (en) | 1987-03-11 | 1992-07-14 | John Cornell | Wound dressings in sheet or gelled paste form |
US5080893A (en) | 1988-05-31 | 1992-01-14 | University Of Florida | Method for preventing surgical adhesions using a dilute solution of polymer |
US5690954A (en) | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
US4887743A (en) | 1987-06-10 | 1989-12-19 | Blake William S | Aerosol valve |
US4752466A (en) | 1987-08-31 | 1988-06-21 | Johnson & Johnson Products, Inc. | Thrombin aerosol |
US5017229A (en) | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
JPS6485653A (en) | 1987-09-28 | 1989-03-30 | Terumo Corp | Drug receiving container |
JPH01130519A (ja) | 1987-11-16 | 1989-05-23 | Mitsubishi Electric Corp | Mocvd結晶成長装置 |
ES2064439T3 (es) | 1988-05-02 | 1995-02-01 | Project Hear | Material adhesivo quirurgico. |
IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
US4936835A (en) | 1988-05-26 | 1990-06-26 | Haaga John R | Medical needle with bioabsorbable tip |
US5350573A (en) | 1988-05-31 | 1994-09-27 | University Of Florida Research Foundation, Inc. | Method and composition for preventing surgical adhesions |
US5140016A (en) | 1988-05-31 | 1992-08-18 | University Of Florida | Method and composition for preventing surgical adhesions using a dilute solution of polymer |
US5024841A (en) | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5447966A (en) | 1988-07-19 | 1995-09-05 | United States Surgical Corporation | Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin |
US4920158A (en) | 1989-10-11 | 1990-04-24 | Medipro Sciences Limited | Hydrogel-forming wound dressing or skin coating material |
BG51589A1 (en) | 1988-08-26 | 1993-07-15 | Bg Min Na Narodnata Otbrana | Method for the production of haemostatic layer material |
US4925677A (en) | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
US5041292A (en) | 1988-08-31 | 1991-08-20 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
EP0365705A1 (de) | 1988-10-26 | 1990-05-02 | Zentralna Problemna Laboratoria Po Kryobiologia I Lyophilisazia | Biopräparat zur Behandlung von Wunden |
US5135751A (en) | 1988-11-16 | 1992-08-04 | Mediventures Incorporated | Composition for reducing postsurgical adhesions |
US5126141A (en) | 1988-11-16 | 1992-06-30 | Mediventures Incorporated | Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides |
US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US5614587A (en) | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
US4891359A (en) * | 1988-12-08 | 1990-01-02 | Johnson & Johnson Patient Care, Inc. | Hemostatic collagen paste composition |
DE3903672C1 (ja) | 1989-02-08 | 1990-02-01 | Lohmann Gmbh & Co Kg | |
US5062834A (en) | 1989-02-24 | 1991-11-05 | Product Development (S.G.Z.) Ltd | Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate |
DK223389D0 (da) | 1989-05-05 | 1989-05-05 | Ferrosan As | Saarsvamp |
KR910007847Y1 (ko) | 1989-05-31 | 1991-10-07 | 삼성중공업 주식회사 | 무한궤도용 슈우플레이트 |
KR910007847B1 (ko) | 1989-06-10 | 1991-10-02 | 한국과학기술원 | 스폰지 구조를 갖는 새로운 다공성 젤라틴 미립 담체 및 그 제조방법 |
US5356883A (en) | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
EP0493387B1 (en) | 1989-08-10 | 1993-10-20 | W.L. Gore & Associates, Inc. | A medical dispensing system for tissue adhesive components |
JPH0790241B2 (ja) | 1989-09-01 | 1995-10-04 | 日本鋼管株式会社 | 条鋼の圧延方法 |
US5196185A (en) | 1989-09-11 | 1993-03-23 | Micro-Collagen Pharmaceutics, Ltd. | Collagen-based wound dressing and method for applying same |
FR2652573B1 (fr) | 1989-10-03 | 1991-12-13 | Atochem | Procede de fabrication du 1,1,1-chlorodifluoroethane. |
US5061274A (en) | 1989-12-04 | 1991-10-29 | Kensey Nash Corporation | Plug device for sealing openings and method of use |
US5350581A (en) | 1989-12-14 | 1994-09-27 | Pharmetrix Corporation | Method for manufacturing transdermal devices |
US5281528A (en) | 1989-12-18 | 1994-01-25 | Warner-Lambert Company | Process for purified thromboplastin for ultra-pure thrombin preparation |
US5219328A (en) | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
US5134229A (en) | 1990-01-12 | 1992-07-28 | Johnson & Johnson Medical, Inc. | Process for preparing a neutralized oxidized cellulose product and its method of use |
US4982769A (en) | 1990-02-21 | 1991-01-08 | Survival Technology, Inc. | Package |
JPH0813750B2 (ja) | 1990-03-01 | 1996-02-14 | 持田製薬株式会社 | 経口用トロンビン製剤 |
US5306501A (en) | 1990-05-01 | 1994-04-26 | Mediventures, Inc. | Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers |
US5595735A (en) | 1990-05-23 | 1997-01-21 | Johnson & Johnson Medical, Inc. | Hemostatic thrombin paste composition |
US5634943A (en) | 1990-07-12 | 1997-06-03 | University Of Miami | Injectable polyethylene oxide gel implant and method for production |
US5292362A (en) | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
US5209776A (en) | 1990-07-27 | 1993-05-11 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
US5108421A (en) | 1990-10-01 | 1992-04-28 | Quinton Instrument Company | Insertion assembly and method of inserting a vessel plug into the body of a patient |
US5192300A (en) | 1990-10-01 | 1993-03-09 | Quinton Instrument Company | Insertion assembly and method of inserting a vessel plug into the body of a patient |
DE59005286D1 (de) | 1990-10-04 | 1994-05-11 | Kallies Import Export Vertrieb | Stabilisiertes Thrombin, seine Herstellung und seine Verwendung als Thrombinzeitreagens. |
ZA918168B (en) | 1990-10-16 | 1993-04-14 | Takeda Chemical Industries Ltd | Prolonged release preparation and polymers thereof. |
US5129882A (en) | 1990-12-27 | 1992-07-14 | Novoste Corporation | Wound clotting device and method of using same |
US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
US5669934A (en) | 1991-02-13 | 1997-09-23 | Fusion Medical Technologies, Inc. | Methods for joining tissue by applying radiofrequency energy to performed collagen films and sheets |
US5749895A (en) | 1991-02-13 | 1998-05-12 | Fusion Medical Technologies, Inc. | Method for bonding or fusion of biological tissue and material |
WO1992014513A1 (en) | 1991-02-13 | 1992-09-03 | Interface Biomedical Laboratories Corp. | Filler material for use in tissue welding |
US5690675A (en) | 1991-02-13 | 1997-11-25 | Fusion Medical Technologies, Inc. | Methods for sealing of staples and other fasteners in tissue |
DK0525132T3 (da) | 1991-02-14 | 1996-02-05 | Baxter Int | Binding af genkendende stoffer til liposomer |
US5605938A (en) | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
DE4119140C2 (de) | 1991-06-11 | 1994-05-11 | Merz & Co Gmbh & Co | Poröser, in Körperflüssigkeiten und Sekreten löslicher, spongoider Formkörper, dessen Herstellung und Verwendung |
CA2089487A1 (en) | 1991-06-14 | 1992-12-15 | Suk-Zu Song | Collagen film drug delivery for proteins |
NL9101051A (nl) | 1991-06-18 | 1993-01-18 | Ashridge Ag | Sluitinrichting voor een bloedvat of dergelijke. |
FR2679772B1 (fr) | 1991-08-02 | 1995-05-19 | Peters Sa | Emboles en particules non resorbables enrobees de materiau hemostatique. |
IT1251151B (it) | 1991-08-05 | 1995-05-04 | Fidia Spa | Materiale spugnoso essenzialmente costituito da acido ialuronico,o suoi derivati |
US6620436B1 (en) | 1991-10-09 | 2003-09-16 | Lectec Corporation | Mixing and dispensing package for a wound dressing |
JPH07500035A (ja) | 1991-10-09 | 1995-01-05 | レクテック コーポレイション | 水性ゲル傷用包帯剤およびパッケージ |
AU2793292A (en) | 1991-10-11 | 1993-05-03 | Novo Nordisk A/S | Hemostatic composition for local hemostasis |
AT398079B (de) | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
WO1993010768A1 (de) | 1991-12-05 | 1993-06-10 | Alfatec-Pharma Gmbh | Pharmazeutisch applizierbares nanosol und verfahren zu seiner herstellung |
US5468505A (en) | 1992-02-28 | 1995-11-21 | Board Of Regents, The University Of Texas System | Local delivery of fibrinolysis enhancing agents |
AU3665693A (en) | 1992-02-28 | 1993-09-13 | Collagen Corporation | High concentration homogenized collagen compositions |
US5204382A (en) | 1992-02-28 | 1993-04-20 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
JPH07504106A (ja) | 1992-02-28 | 1995-05-11 | コラーゲン コーポレイション | 注射可能なセラミック組成物及びそれらの製造及び使用のための方法 |
US5384333A (en) | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
GB9206509D0 (en) | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges containing active agents |
GB2266239B (en) | 1992-03-25 | 1996-03-06 | Jevco Ltd | Wound healing compositions containing chondroitin sulphate oligosaccharides |
WO1993021844A1 (en) | 1992-04-23 | 1993-11-11 | Scimed Life Systems, Inc. | Apparatus and method for sealing vascular punctures |
IL105529A0 (en) | 1992-05-01 | 1993-08-18 | Amgen Inc | Collagen-containing sponges as drug delivery for proteins |
JPH05308969A (ja) | 1992-05-13 | 1993-11-22 | Japan Vilene Co Ltd | 酵素保持体及びその製造方法 |
AU4406793A (en) | 1992-06-04 | 1993-12-30 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
US5547376A (en) | 1992-06-18 | 1996-08-20 | Harrel; Stephen K. | Methods and apparatus for containing and recovering abrasive powders from an abrasive polisher |
US5385606A (en) | 1992-07-06 | 1995-01-31 | Kowanko; Nicholas | Adhesive composition and method |
US5413571A (en) | 1992-07-16 | 1995-05-09 | Sherwood Medical Company | Device for sealing hemostatic incisions |
US5443481A (en) | 1992-07-27 | 1995-08-22 | Lee; Benjamin I. | Methods and device for percutaneous sealing of arterial puncture sites |
US5428022A (en) | 1992-07-29 | 1995-06-27 | Collagen Corporation | Composition of low type III content human placental collagen |
US5514379A (en) | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
DE4227681C2 (de) | 1992-08-21 | 1995-05-18 | Becker & Co Naturinwerk | Wundabdeckungsmaterial auf der Basis von Kollagenfasern und Verfahren zu seiner Herstellung |
AU4926193A (en) | 1992-09-21 | 1994-04-12 | Vitaphore Corporation | Embolization plugs for blood vessels |
SK279327B6 (sk) | 1992-10-19 | 1998-10-07 | Dura Pharmaceuticals | Zariadenie na vytváranie aerosolu z práškového lie |
ATE206602T1 (de) | 1992-11-12 | 2001-10-15 | Neville Alleyne | Einrichtung zum schutz des herzens |
US5334216A (en) | 1992-12-10 | 1994-08-02 | Howmedica Inc. | Hemostatic plug |
JPH0824325B2 (ja) | 1993-01-25 | 1996-03-06 | 日本電気株式会社 | 携帯電話機 |
US5667839A (en) | 1993-01-28 | 1997-09-16 | Collagen Corporation | Human recombinant collagen in the milk of transgenic animals |
IT1263144B (it) | 1993-02-04 | 1996-08-01 | Lanfranco Callegaro | Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive |
JPH08131B2 (ja) | 1993-03-05 | 1996-01-10 | 新田ゼラチン株式会社 | 止血用パッド |
DE69429337T3 (de) | 1993-04-02 | 2012-08-30 | Anticancer Inc. | Verfahren zur verabreichung von förderlichen zusammensetzungen auf die haarfollikel |
AU6705894A (en) | 1993-04-20 | 1994-11-08 | Medchem Products, Inc. | Apparatus and method for applying a particulate hemostatic agent to living tissue |
US5723308A (en) | 1993-05-14 | 1998-03-03 | Minnesota Mining And Manufacturing Company | Culture medium for rapid count of coliform bacteria |
US5951583A (en) | 1993-05-25 | 1999-09-14 | Vascular Solutions, Inc. | Thrombin and collagen procoagulant and process for making the same |
WO1994027630A1 (fr) | 1993-05-31 | 1994-12-08 | Kaken Pharmaceutical Co., Ltd. | Preparation de gel a base de gelatine reticulee contenant un facteur de croissance de fibroblaste de base |
US5387208A (en) | 1993-07-26 | 1995-02-07 | The Procter & Gamble Co. | Absorbent core having improved dry/wet integrity |
US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
US6861046B1 (en) | 1993-08-18 | 2005-03-01 | Dow Corning France | Device for dispensing a therapeutic or cosmetic substance onto the skin and a method of skin treatment |
US5394886A (en) | 1993-09-20 | 1995-03-07 | Nabai; Hossein | Skin biopsy plug and method |
JPH0790241A (ja) | 1993-09-22 | 1995-04-04 | Menicon Co Ltd | 眼用レンズ材料用仮接着剤 |
CA2175203A1 (en) | 1993-11-03 | 1995-05-11 | Thaddeus P. Pruss | Hemostatic patch |
WO1995018216A1 (fr) | 1993-12-30 | 1995-07-06 | Nitta Gelatin Inc. | Procedes permettant d'enrober des cultures de cellules animales |
FR2715309B1 (fr) | 1994-01-24 | 1996-08-02 | Imedex | Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé. |
US5441491A (en) | 1994-02-04 | 1995-08-15 | Verschoor; Jacob | Method and composition for treating biopsy wounds |
DE4407875C2 (de) | 1994-03-04 | 1996-04-04 | Ankerpharm Gmbh Ankerwerk Rudo | Medizinischer Schwamm aus biologisch resorbierbaren Materialien, Verfahren und Vorrichtung zu dessen Herstellung |
CA2162997A1 (en) | 1994-03-18 | 1995-09-28 | Daphne C. Tse | Topical fibrinogen complex |
ITPD940054A1 (it) | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
US5674275A (en) | 1994-04-06 | 1997-10-07 | Graphic Controls Corporation | Polyacrylate and polymethacrylate ester based hydrogel adhesives |
US5531759A (en) | 1994-04-29 | 1996-07-02 | Kensey Nash Corporation | System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating |
CA2146090C (en) | 1994-05-10 | 1998-11-24 | Mark E. Mitchell | Apparatus and method of mixing materials in a sterile environment |
JP3107726B2 (ja) | 1994-05-13 | 2000-11-13 | 株式会社クラレ | 水膨潤性高分子ゲル |
WO1995031223A1 (fr) | 1994-05-13 | 1995-11-23 | Kuraray Co., Ltd. | Gel polymere a usage medical |
KR970703123A (ko) | 1994-05-23 | 1997-07-03 | 카롤 질레스피 | 조성물 준비 장치(formulation preparation device) |
US5462860A (en) | 1994-06-06 | 1995-10-31 | Minnesota Mining And Manufacturing Company | Conditioned culture medium for rapid growth and detection of microbes |
GB9415739D0 (en) | 1994-07-30 | 1994-09-21 | Scimat Ltd | Gel wound dressing |
US5599735A (en) | 1994-08-01 | 1997-02-04 | Texas Instruments Incorporated | Method for doped shallow junction formation using direct gas-phase doping |
US5516532A (en) | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
US5588745A (en) | 1994-09-02 | 1996-12-31 | Howmedica | Methods and apparatus for mixing bone cement components using an evacuated mixing chamber |
US5931165A (en) | 1994-09-06 | 1999-08-03 | Fusion Medical Technologies, Inc. | Films having improved characteristics and methods for their preparation and use |
JP2858087B2 (ja) | 1994-09-19 | 1999-02-17 | グンゼ株式会社 | 組織培養用基材及び組織培養法 |
AU1287895A (en) | 1994-10-03 | 1996-04-26 | Otogen Corporation | Differentially biodegradable biomedical implants |
FR2726571B1 (fr) | 1994-11-03 | 1997-08-08 | Izoret Georges | Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique |
US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
US5804203A (en) | 1994-12-21 | 1998-09-08 | Cosmederm Technologies | Topical product formulations containing strontium for reducing skin irritation |
WO1996022115A1 (en) | 1995-01-16 | 1996-07-25 | Baxter International Inc. | Self-supporting sheet-like material of cross-linked fibrin for preventing post operative adhesions |
US20030039695A1 (en) | 2001-08-10 | 2003-02-27 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Collagen carrier of therapeutic genetic material, and method |
US5698213A (en) | 1995-03-06 | 1997-12-16 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters |
US5580923A (en) | 1995-03-14 | 1996-12-03 | Collagen Corporation | Anti-adhesion films and compositions for medical use |
US5876372A (en) | 1995-03-22 | 1999-03-02 | Abbott Laboratories | Syringe system accomodating seperate prefilled barrels for two constituents |
DE19513666C1 (de) | 1995-04-11 | 1996-11-28 | Behringwerke Ag | Vorrichtung zum Zusammenführen einer ersten flüssigen und einer zweiten festen oder flüssigen Komponente mittels Unterdruck unter sterilen Bedingungen |
JP3799626B2 (ja) | 1995-04-25 | 2006-07-19 | 有限会社ナイセム | 心臓血管修復材及びその製造方法 |
US5677284A (en) | 1995-06-06 | 1997-10-14 | Regen Biologics, Inc. | Charged collagen particle-based delivery matrix |
US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
WO1996040033A1 (en) | 1995-06-07 | 1996-12-19 | Clarion Pharmaceuticals Inc. | Non-biological patch for hemostasis |
DE19521324C1 (de) | 1995-06-12 | 1996-10-31 | Immuno Ag | Gewebeklebstoff und Verwendung desselben als Hämostyptikum |
BG99900A (en) | 1995-09-04 | 1997-03-31 | Bildireva | Absorbent sponge of haemostatic application and method for its preparation |
AU7398196A (en) | 1995-10-11 | 1997-04-30 | Fusion Medical Technologies, Inc. | Device and method for sealing tissue |
WO1997017025A1 (en) | 1995-11-07 | 1997-05-15 | Fusion Medical Technologies, Inc. | Methods and articles for fusing matrix layers containing non-collagenous proteins to tissue |
WO1997017023A1 (en) | 1995-11-07 | 1997-05-15 | Fusion Medical Technologies, Inc. | Methods and articles for fusing polysaccharide-containing matrix layers to tissue |
WO1997017024A1 (en) | 1995-11-07 | 1997-05-15 | Fusion Medical Technologies, Inc. | Methods and articles for fusing matrix layers containing non-biologic polymers to tissue |
US6464111B2 (en) | 1995-11-13 | 2002-10-15 | L'oreal | Dispenser containing a product and dispensing method |
EP1704878B1 (en) | 1995-12-18 | 2013-04-10 | AngioDevice International GmbH | Crosslinked polymer compositions and methods for their use |
US5752974A (en) | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
US6458889B1 (en) | 1995-12-18 | 2002-10-01 | Cohesion Technologies, Inc. | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
US5748318A (en) | 1996-01-23 | 1998-05-05 | Brown University Research Foundation | Optical stress generator and detector |
JP2002514948A (ja) | 1996-02-20 | 2002-05-21 | コーヒージョン・コーポレーション | 組織シーラント組成物とその使用方法 |
US5782917A (en) | 1996-02-26 | 1998-07-21 | Sunmed, Inc. | Intramedullary bone plug |
ES2241030T3 (es) | 1996-03-20 | 2005-10-16 | Baxter Aktiengesellschaft | Preparado farmaceutico para el tratamiento de alteraciones de la coagulacion sanguinea. |
HUP9903586A3 (en) | 1996-04-04 | 2003-02-28 | Baxter Ag | Hemostatic sponge based on collagen |
US5948427A (en) | 1996-04-25 | 1999-09-07 | Point Medical Corporation | Microparticulate surgical adhesive |
EP0914168A1 (en) | 1996-05-03 | 1999-05-12 | Innogenetics N.V. | New medicaments containing gelatin cross-linked with oxidized polysaccharides |
JP4024302B2 (ja) | 1996-05-17 | 2007-12-19 | クアドラント、 ドラッグ、 デリバリー、 リミテッド | 微粒子および創傷治療におけるその用途 |
FR2749759B1 (fr) | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
US5791352A (en) | 1996-06-19 | 1998-08-11 | Fusion Medical Technologies, Inc. | Methods and compositions for inhibiting tissue adhesion |
EP0917444A1 (en) | 1996-07-12 | 1999-05-26 | Baxter Travenol Laboratories, Inc. | A fibrin delivery device and method for forming fibrin on a surface |
US5902832A (en) | 1996-08-20 | 1999-05-11 | Menlo Care, Inc. | Method of synthesizing swollen hydrogel for sphincter augmentation |
US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
US7320962B2 (en) | 1996-08-27 | 2008-01-22 | Baxter International Inc. | Hemoactive compositions and methods for their manufacture and use |
US7435425B2 (en) | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
US6706690B2 (en) | 1999-06-10 | 2004-03-16 | Baxter Healthcare Corporation | Hemoactive compositions and methods for their manufacture and use |
US6063061A (en) | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
US7871637B2 (en) | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
CA2211629A1 (en) | 1996-09-17 | 1998-03-17 | Bernard Sams | Vial connector assembly for a medicament container |
AU4648697A (en) | 1996-09-23 | 1998-04-14 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
US5795330A (en) | 1996-10-10 | 1998-08-18 | Etex Corporation | Mixing device |
US7341598B2 (en) | 1999-01-13 | 2008-03-11 | Boston Scientific Scimed, Inc. | Stent with protruding branch portion for bifurcated vessels |
US5863496A (en) | 1996-11-25 | 1999-01-26 | Prepared Media Laboratory, Inc. | Sterile packaging |
CA2277814A1 (en) | 1997-01-16 | 1998-07-23 | Cohesion Corporation | Lyophilized collagen-based biomaterials, process of preparation and uses thereof |
US6045570A (en) | 1997-02-11 | 2000-04-04 | Biointerventional Corporation | Biological sealant mixture and system for use in percutaneous occlusion of puncture sites and tracts in the human body and method |
US5782860A (en) | 1997-02-11 | 1998-07-21 | Biointerventional Corporation | Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method |
US6193670B1 (en) | 1997-02-14 | 2001-02-27 | Tricardia, Llc | Hemostatic agent delivery device having built-in pressure sensor |
US5905029A (en) | 1997-02-19 | 1999-05-18 | Fritz Berthold | Method for rapid hygiene testing |
KR100526913B1 (ko) | 1997-02-20 | 2005-11-09 | 쿡 인코포레이티드 | 코팅된 이식가능한 의료 장치 |
FR2759980A1 (fr) | 1997-02-25 | 1998-08-28 | Bras Michel | Conditionnement de deux substances destinees a etre melangees |
US5965377A (en) | 1997-03-24 | 1999-10-12 | Baystate Medical Center | Method for determining the presence of mutated BRCA protein |
US5939259A (en) | 1997-04-09 | 1999-08-17 | Schleicher & Schuell, Inc. | Methods and devices for collecting and storing clinical samples for genetic analysis |
US6117444A (en) | 1997-04-10 | 2000-09-12 | Brigham & Women's Hospital | Polyethylene glycol/microfibrillar collagen composite serves as a resorbable hemostatic agent |
US6716435B1 (en) | 1997-04-18 | 2004-04-06 | Ganeden Biotech, Inc. | Absorbent product containing absorbent structure and Bacillus coagulans |
US20020039594A1 (en) | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
JP3602145B2 (ja) | 1997-06-03 | 2004-12-15 | イノジェネティックス・ナムローゼ・フェンノートシャップ | メタクリルアミド修飾ゼラチンから構成されるポリマーに基づく新たな医薬品 |
US5908054A (en) | 1997-06-16 | 1999-06-01 | Fusion Medical Technologies, Inc. | Fluid dispersion and delivery assembly and method |
US5957166A (en) | 1997-06-16 | 1999-09-28 | Fusion Medical Technologies, Inc. | Method and apparatus for dispersing fluid into a material |
WO1998057678A2 (en) * | 1997-06-18 | 1998-12-23 | Cohesion Technologies, Inc. | Compositions containing thrombin and microfibrillar collagen |
IT1294797B1 (it) | 1997-07-28 | 1999-04-15 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante |
US6042262A (en) | 1997-07-29 | 2000-03-28 | Stryker Technologies Corportion | Apparatus for storing, mixing, and dispensing two-component bone cement |
US6171276B1 (en) | 1997-08-06 | 2001-01-09 | Pharmacia & Upjohn Ab | Automated delivery device and method for its operation |
US6162241A (en) | 1997-08-06 | 2000-12-19 | Focal, Inc. | Hemostatic tissue sealants |
AU742675B2 (en) | 1997-08-22 | 2002-01-10 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid gel, method of its production and medical material containing it |
AU9111698A (en) | 1997-09-04 | 1999-03-22 | Pharmacia & Upjohn Company | A method for the evaluation of antiviral drugs |
DE69831964T2 (de) | 1997-09-16 | 2006-07-27 | Integra Lifesciences Corp. | Zusammensetzung zur förderung des wachstums von duralem oder meningealem gewebe enthaltend kollagen |
US5997895A (en) | 1997-09-16 | 1999-12-07 | Integra Lifesciences Corporation | Dural/meningeal repair product using collagen matrix |
US6168788B1 (en) | 1997-09-26 | 2001-01-02 | Leon Wortham | Fibrin glue without fibrinogen and biosealant compositions and methods |
GB2329840C (en) | 1997-10-03 | 2007-10-05 | Johnson & Johnson Medical | Biopolymer sponge tubes |
US6303323B1 (en) | 1997-10-21 | 2001-10-16 | Cancer Research Campaign Technology Limited | Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies |
JPH11155951A (ja) | 1997-12-01 | 1999-06-15 | Kaken Pharmaceut Co Ltd | 減圧シリンジおよびその製造方法 |
GB9727102D0 (en) | 1997-12-22 | 1998-02-25 | Andaris Ltd | Microparticles and their therapeutic use |
JP3483753B2 (ja) | 1997-12-29 | 2004-01-06 | タキロン株式会社 | 生体内分解吸収性可塑性粘着物 |
US6099952A (en) | 1998-02-18 | 2000-08-08 | Xomed Surgical Products, Inc. | Medical sponge having mucopolysaccharide coating |
ES2293719T3 (es) | 1998-03-06 | 2008-03-16 | Baxter International Inc. | Cabezal mezclador con turbulencia para un aplicador de adhesivo quirurgico y cabezal de pulverizacion correspondiente. |
AUPP223498A0 (en) | 1998-03-06 | 1998-04-02 | Southcorp Australia Pty Ltd | A container |
EP1061931A2 (en) | 1998-03-10 | 2000-12-27 | Baxter International Inc. | Thrombin preparation and products and fibrin sealant methods employing same |
US6179872B1 (en) | 1998-03-17 | 2001-01-30 | Tissue Engineering | Biopolymer matt for use in tissue repair and reconstruction |
US6092543A (en) | 1998-03-18 | 2000-07-25 | Roh; Warren E. | Protective cover for a baby carrier which provides sun, insect, and impact protection |
US20020025921A1 (en) | 1999-07-26 | 2002-02-28 | Petito George D. | Composition and method for growing, protecting, and healing tissues and cells |
CA2327685C (en) | 1998-04-03 | 2008-11-18 | Bm Research A/S | Controlled release composition |
US20020061842A1 (en) | 1998-04-10 | 2002-05-23 | Octapharma Ag | Method for sterilizing a native collagen in liquid medium, sterile native collagen obtained, compositions containing it and uses |
US6200328B1 (en) | 1998-05-01 | 2001-03-13 | Sub Q, Incorporated | Device and method for facilitating hemostasis of a biopsy tract |
US6056970A (en) * | 1998-05-07 | 2000-05-02 | Genzyme Corporation | Compositions comprising hemostatic compounds and bioabsorbable polymers |
ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
US6613070B2 (en) | 1998-08-04 | 2003-09-02 | Baxter International Inc. | System and method for sealing vascular penetrations with hemostatic gels |
JP2003521270A (ja) | 1998-08-04 | 2003-07-15 | フュージョン メディカル テクノロジーズ, インコーポレイテッド | 経皮組織路閉塞アセンブリおよび方法 |
US6334865B1 (en) | 1998-08-04 | 2002-01-01 | Fusion Medical Technologies, Inc. | Percutaneous tissue track closure assembly and method |
US6274090B1 (en) | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
WO2000009018A1 (en) | 1998-08-10 | 2000-02-24 | Fibrogen, Inc. | Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing |
US20020015724A1 (en) | 1998-08-10 | 2002-02-07 | Chunlin Yang | Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing |
JP2003517997A (ja) | 1998-11-12 | 2003-06-03 | ポリマー・バイオサイエンシス,インコーポレイテッド | 急速な血液凝集及び止血に有用な止血ポリマー |
US6110484A (en) | 1998-11-24 | 2000-08-29 | Cohesion Technologies, Inc. | Collagen-polymer matrices with differential biodegradability |
US6454787B1 (en) | 1998-12-11 | 2002-09-24 | C. R. Bard, Inc. | Collagen hemostatic foam |
US6361551B1 (en) | 1998-12-11 | 2002-03-26 | C. R. Bard, Inc. | Collagen hemostatic fibers |
US6328229B1 (en) | 1998-12-18 | 2001-12-11 | Cohesion Technologies, Inc. | Low volume mixing spray head for mixing and dispensing of two reactive fluid components |
US6283933B1 (en) | 1998-12-23 | 2001-09-04 | Closure Medical Corporation | Applicator for dispensable liquids |
WO2000038752A1 (de) | 1998-12-23 | 2000-07-06 | Aventis Behring Gmbh | Fibrinklebergranulat und verfahren zu dessen herstellung |
DE60018814T2 (de) | 1999-01-21 | 2006-04-06 | Nipro Corp. | Nähbare Membran zur Adhäsionsverhinderung |
US6862470B2 (en) | 1999-02-02 | 2005-03-01 | Senorx, Inc. | Cavity-filling biopsy site markers |
EP1174463A4 (en) | 1999-02-19 | 2008-04-16 | Denki Kagaku Kogyo Kk | HYALURONIC ACID-BASED GELIFIED COMPOSITION, PROCESS FOR THE PRODUCTION THEREOF, AND MEDICAL MATERIAL CONTAINING THE SAME |
JP2002540900A (ja) | 1999-04-14 | 2002-12-03 | ガネデン バイオテック, インコーポレイテッド | 衛生製品に関連する微生物感染の阻害方法 |
US6312725B1 (en) | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
EP1053758A1 (de) | 1999-05-19 | 2000-11-22 | Resorba Chirurgisches Nahtmaterial Franz Hiltner GmbH & Co. | Bioabsorbierbares Implantat |
US6544541B1 (en) | 1999-06-02 | 2003-04-08 | Cardiovascular Solutions, Inc. | Devices and compounds for treating arterial restenosis |
US6472162B1 (en) | 1999-06-04 | 2002-10-29 | Thermogenesis Corp. | Method for preparing thrombin for use in a biological glue |
US20020019062A1 (en) | 1999-06-18 | 2002-02-14 | Peter Lea | Assay devices |
EP1212093B1 (en) | 1999-08-26 | 2004-07-07 | Ganeden Biotech, Inc. | Use of emu oil as a carrier for antifungal, antibacterial and antiviral medications |
EP1218437B1 (en) | 1999-08-27 | 2009-06-17 | AngioDevice International GmbH | Compositions that form interpenetrating polymer networks for use as high strength medical sealants |
US6221109B1 (en) | 1999-09-15 | 2001-04-24 | Ed. Geistlich Söhne AG fur Chemische Industrie | Method of protecting spinal area |
US6312474B1 (en) | 1999-09-15 | 2001-11-06 | Bio-Vascular, Inc. | Resorbable implant materials |
EP1220693B1 (en) | 1999-10-15 | 2004-12-08 | Genetics Institute, LLC | Formulations for delivery of osteogenic proteins |
JP2001199903A (ja) | 1999-11-09 | 2001-07-24 | Eizo Mori | 核酸含有複合体 |
AU2351601A (en) | 1999-12-28 | 2001-07-09 | Asger Lau Dalmose | Dual chamber syringe with a dual function piston |
US20030095993A1 (en) | 2000-01-28 | 2003-05-22 | Hanne Bentz | Gel-infused sponges for tissue repair and augmentation |
WO2001054735A2 (en) | 2000-01-28 | 2001-08-02 | Orthogene, Inc. | Gel-infused sponges for tissue repair and augmentation |
IT1317832B1 (it) | 2000-02-15 | 2003-07-15 | Eurores S R L | Procedimento per la preparazione di collagene micronizzato e sueapplicazioni terapeutiche. |
EP1286707A2 (en) | 2000-02-18 | 2003-03-05 | Regeneration Technologies, Inc. | Implantable tissues infused with growth factors and other additives |
US7220276B1 (en) | 2000-03-06 | 2007-05-22 | Surmodics, Inc. | Endovascular graft coatings |
JP4580610B2 (ja) | 2000-04-04 | 2010-11-17 | リンテック株式会社 | 粘着力測定装置 |
CN1114728C (zh) | 2000-04-21 | 2003-07-16 | 中国石油化工集团公司 | 止血纤维及其制造方法 |
EP1149906A1 (en) | 2000-04-25 | 2001-10-31 | Pliva, Farmaceutska, Industrija, Dionicko Drustvo | Thrombopoietin receptor modulating peptide |
CA2407235A1 (en) | 2000-04-28 | 2001-11-08 | Fziomed, Inc. | Hemostatic compositions of polyacids and polyalkylene oxides and methods for their use |
WO2001097826A2 (en) | 2000-06-16 | 2001-12-27 | University Of Medicine And Dentistry Of New Jersey | Hemostatic compositions, devices and methods |
AT411326B (de) | 2000-06-20 | 2003-12-29 | Biering Wolfgang | Hämostatische collagen-pellets |
AT412445B (de) | 2000-06-20 | 2005-03-25 | Biering Wolfgang | Flüssiges collagen-hämostatikum |
JP2004504330A (ja) | 2000-07-13 | 2004-02-12 | インヴィトロジェン コーポレーション | 溶解マトリクスを用いてタンパク質およびペプチドの迅速な抽出および単離のための方法および組成物 |
US6554903B1 (en) | 2000-07-19 | 2003-04-29 | Nylok Corporation | Unitary spray nozzle |
US20030032143A1 (en) | 2000-07-24 | 2003-02-13 | Neff Thomas B. | Collagen type I and type III compositions for use as an adhesive and sealant |
AU2001265400A1 (en) | 2000-07-28 | 2002-02-13 | Anika Therapeutics, Inc. | Bioabsorbable composites of derivatized hyaluronic acid |
US6890342B2 (en) | 2000-08-02 | 2005-05-10 | Loma Linda University | Method and apparatus for closing vascular puncture using hemostatic material |
IT1317358B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Derivati cross-linkati dell'acido ialuronico. |
CN1455659A (zh) | 2000-09-12 | 2003-11-12 | 弗吉尼亚州立大学 | 高压出血的治疗 |
CA2777791A1 (en) | 2000-09-18 | 2002-03-21 | Organogenesis Inc. | Methods for treating a patient using a bioengineered flat sheet graft prostheses |
US6364519B1 (en) | 2000-09-26 | 2002-04-02 | Smith & Nephew, Inc. | Bone cement system |
US6309221B1 (en) * | 2000-10-13 | 2001-10-30 | Ultradent Products, Inc. | Compositions, methods and kits for hemostasis and sealing of pulp during invasive dental procedures |
US6635272B2 (en) | 2000-11-09 | 2003-10-21 | Richard N. Leaderman | Wound dressing and drug delivery system |
US6458380B1 (en) | 2000-11-09 | 2002-10-01 | Richard Leaderman | Dressing and preparation delivery system |
US20030009194A1 (en) | 2000-12-07 | 2003-01-09 | Saker Mark B. | Tissue tract sealing device |
US20020082620A1 (en) | 2000-12-27 | 2002-06-27 | Elaine Lee | Bioactive materials for aneurysm repair |
US7041868B2 (en) | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Bioabsorbable wound dressing |
US6733774B2 (en) | 2001-01-25 | 2004-05-11 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
TWI237573B (en) | 2001-01-25 | 2005-08-11 | Nycomed Pharma As | A method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge |
US20020164322A1 (en) | 2001-01-25 | 2002-11-07 | Alfred Schaufler | Suspension comprising fibrinogen, thrombin and alcohol, a method for preparing such a suspension, a method for coating a carrier with such a suspension, a method of drying a coating of a carrier, and a coated collagen sponge |
US7052713B2 (en) | 2001-02-13 | 2006-05-30 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
WO2002064182A2 (en) | 2001-02-14 | 2002-08-22 | Genzyme Corporation | Biocompatible fleece for hemostasis and tissue engineering |
US8187625B2 (en) | 2001-03-12 | 2012-05-29 | Boston Scientific Scimed, Inc. | Cross-linked gelatin composition comprising a wetting agent |
TW526069B (en) | 2001-04-10 | 2003-04-01 | Sod Conseils Rech Applic | Injection device |
US6685745B2 (en) | 2001-05-15 | 2004-02-03 | Scimed Life Systems, Inc. | Delivering an agent to a patient's body |
BR0102637A (pt) | 2001-05-17 | 2003-02-25 | Johnson & Johnson Ind Com | Curativo adesivo |
US20050271737A1 (en) | 2001-06-07 | 2005-12-08 | Chinea Vanessa I | Application of a bioactive agent to a substrate |
US6962715B2 (en) | 2001-10-24 | 2005-11-08 | Hewlett-Packard Development Company, L.P. | Method and dosage form for dispensing a bioactive substance |
US7371403B2 (en) | 2002-06-14 | 2008-05-13 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
US6676987B2 (en) | 2001-07-02 | 2004-01-13 | Scimed Life Systems, Inc. | Coating a medical appliance with a bubble jet printing head |
EP2957281A1 (en) | 2001-09-21 | 2015-12-23 | Egalet Ltd. | Polymer release system |
WO2003024426A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Controlled release solid dispersions |
JP4668510B2 (ja) | 2001-09-29 | 2011-04-13 | 持田製薬株式会社 | 可撓性容器入り局所止血用医薬組成物 |
JP4112851B2 (ja) | 2001-11-27 | 2008-07-02 | テルモ株式会社 | 2室型プレフィルドシリンジ |
US7923431B2 (en) | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
AU2002367086B2 (en) | 2001-12-21 | 2008-08-21 | Ferrosan Medical Devices A/S | A hemostatic kit, a method of preparing a hemostatic agent and a method of promoting hemostasis |
JP4152104B2 (ja) | 2001-12-28 | 2008-09-17 | テルモ株式会社 | シリンジおよびガスケット |
US20060189516A1 (en) | 2002-02-19 | 2006-08-24 | Industrial Technology Research Institute | Method for producing cross-linked hyaluronic acid-protein bio-composites |
CN101898004A (zh) | 2002-02-20 | 2010-12-01 | 21世纪国际新技术株式会社 | 施用药物的装置 |
JP4489437B2 (ja) | 2002-02-21 | 2010-06-23 | エンセル,インコーポレイテッド | 表面コーティングとしての固定化生物活性ヒドロゲルマトリックス |
US20030175410A1 (en) | 2002-03-18 | 2003-09-18 | Campbell Phil G. | Method and apparatus for preparing biomimetic scaffold |
US20030225378A1 (en) | 2002-04-26 | 2003-12-04 | Surgical Sealants, Inc. | Mixing device for surgical sealants, and method thereof |
WO2003094983A1 (de) | 2002-05-08 | 2003-11-20 | Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) | Resorbierbare pharmazeutische formulierung zur kontinuierlichen thrombinfreisetzung |
US7670623B2 (en) | 2002-05-31 | 2010-03-02 | Materials Modification, Inc. | Hemostatic composition |
US20050137512A1 (en) | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
US20040101546A1 (en) | 2002-11-26 | 2004-05-27 | Gorman Anne Jessica | Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents |
US20040120993A1 (en) | 2002-12-20 | 2004-06-24 | Guanghui Zhang | Hemostatic wound dressing and fabric and methods of making and using same |
ATE487470T1 (de) | 2002-09-11 | 2010-11-15 | Elan Pharma Int Ltd | Gel-stabilisierte wirkstoff-zusammensetzungen in nanoteilchengrösse |
GB2393120A (en) | 2002-09-18 | 2004-03-24 | Johnson & Johnson Medical Ltd | Compositions for wound treatment |
JP2006515186A (ja) | 2002-09-26 | 2006-05-25 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 血管周囲ラップ |
GB2393655B (en) | 2002-09-27 | 2005-08-24 | Johnson & Johnson Medical Ltd | Wound treatment device |
AU2003279730A1 (en) | 2002-09-30 | 2004-04-19 | Fibrogen, Inc. | Dry tissue sealant compositions |
IL152030A0 (en) | 2002-09-30 | 2003-05-29 | Nvr Labs Ltd Neural & Vascular | Cohesive biopolymers comprising sulfated polysaccharides and fibrillar proteins and use thereof for tissue repair |
GB2393656B (en) | 2002-10-01 | 2005-11-16 | Johnson & Johnson Medical Ltd | Enzyme-sensitive therapeutic wound dressings |
US7135027B2 (en) | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
ITPD20020271A1 (it) | 2002-10-18 | 2004-04-19 | Fidia Farmaceutici | Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati. |
US20040079763A1 (en) | 2002-10-29 | 2004-04-29 | Powell Cindy Hagood | Duplex storage pouch |
JP2004147959A (ja) | 2002-10-31 | 2004-05-27 | Nipro Corp | 2成分混合型プレフィルドシリンジ |
IL152574A (en) | 2002-10-31 | 2009-09-22 | Transpharma Medical Ltd | A system for passing through the skin of dry items or dried medicines |
US20060121080A1 (en) | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
PL377477A1 (pl) | 2002-12-11 | 2006-02-06 | Ferrosan A/S | Materiały na bazie żelatyny jako waciki |
US7699804B2 (en) | 2003-01-31 | 2010-04-20 | Creare Inc. | Fluid ejection system |
GB0304716D0 (en) | 2003-02-28 | 2003-04-02 | Uws Ventures Ltd | Method for producing partially frozen ice-water-air mixtures |
US7112713B2 (en) | 2003-03-12 | 2006-09-26 | Gelsus Research And Consulting, Inc. | Dressing based on the Teorell-Meyer gradient |
US20040181183A1 (en) | 2003-03-12 | 2004-09-16 | Sceusa Nicholas A. | Bandage based on the teorell-meyer gradient |
JP4989217B2 (ja) | 2003-03-26 | 2012-08-01 | エガレット エイ/エス | 薬剤物質の送達制御用マトリックス組成物 |
US7051654B2 (en) | 2003-05-30 | 2006-05-30 | Clemson University | Ink-jet printing of viable cells |
GB2403409B (en) | 2003-06-05 | 2005-11-23 | Baxter Int | Methods for repairing and regenerating human dura mater |
US8834864B2 (en) | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
CN1835723B (zh) | 2003-06-16 | 2011-06-22 | 洛马林达大学医学中心 | 可展开的多功能止血剂 |
EP1643934A4 (en) | 2003-06-16 | 2008-05-28 | Univ Loma Linda Med | DEPLOYABLE HEMOSTATIC AGENT |
US7129210B2 (en) | 2003-07-23 | 2006-10-31 | Covalent Medical, Inc. | Tissue adhesive sealant |
US20060019868A1 (en) | 2004-01-30 | 2006-01-26 | Pendharkar Sanyog M | Hemostatic compositions and devices |
US7927626B2 (en) | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
KR100588614B1 (ko) | 2003-11-10 | 2006-06-13 | 주식회사 바이오레인 | 기포를 포함하는 유착방지제 |
CA2536042A1 (en) | 2003-11-10 | 2005-06-02 | Angiotech International Ag | Medical implants and anti-scarring agents |
CN1270240C (zh) | 2003-12-10 | 2006-08-16 | 中国科学院计算技术研究所 | 一种大规模机群系统的监控方法 |
JP2005169008A (ja) | 2003-12-15 | 2005-06-30 | Nipro Corp | 生体適合性材料の滅菌方法 |
US20050136112A1 (en) | 2003-12-19 | 2005-06-23 | Pediamed Pharmaceuticals, Inc. | Oral medicament delivery system |
US7109163B2 (en) * | 2004-01-30 | 2006-09-19 | Ethicon, Inc. | Hemostatic compositions and devices |
CA2554994C (en) * | 2004-01-30 | 2015-05-19 | Ferrosan A/S | Haemostatic sprays and compositions |
EP1602365A1 (en) | 2004-03-03 | 2005-12-07 | Switch Biotech Aktiengesellschaft | Pharmaceutical composition for topical use in form of xerogels or films and methods for production |
US20050218541A1 (en) | 2004-04-02 | 2005-10-06 | Peng Henry T | Method of producing interpenetrating polymer network |
US20050245905A1 (en) | 2004-04-30 | 2005-11-03 | Schmidt Steven P | Local drug-delivery system |
GB2414021A (en) | 2004-05-10 | 2005-11-16 | Johnson & Johnson Medical Ltd | Absorbable haemostatic materials |
US8383154B2 (en) | 2004-05-11 | 2013-02-26 | Egalet A/S | Swellable dosage form comprising gellan gum |
SE527528C2 (sv) | 2004-06-22 | 2006-04-04 | Bone Support Ab | Anordning för framställning av härdbar massa samt användning av anordningen |
US7393674B2 (en) | 2004-06-22 | 2008-07-01 | Zymogenetics, Inc. | Thrombin compositions |
US8119160B2 (en) | 2004-06-29 | 2012-02-21 | Ethicon, Inc. | Hemostatic compositions and devices |
US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
US8021684B2 (en) | 2004-07-09 | 2011-09-20 | Ferrosan Medical Devices A/S | Haemostatic composition comprising hyaluronic acid |
WO2006031358A2 (en) | 2004-08-13 | 2006-03-23 | Hyperbranch Medical Technology, Inc. | Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses |
US20080091277A1 (en) | 2004-08-13 | 2008-04-17 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
WO2006036984A2 (en) | 2004-09-28 | 2006-04-06 | Atrium Medical Corporation | Stand-alone film and methods for making the same |
ES2581558T3 (es) | 2004-09-30 | 2016-09-06 | Covalon Technologies Inc. | Matrices de gelatina elásticas no adhesivas |
ES2226587B1 (es) | 2004-10-22 | 2005-12-16 | Probitas Pharma, S.A. | Composicion de trombina estable. |
AU2005312310A1 (en) | 2004-12-03 | 2006-06-08 | Duoject Medical Systems Inc. | Cartridge, device and method for pharmaceutical storage, mixing and delivery |
DE602005009978D1 (de) | 2004-12-14 | 2008-11-06 | Fidia Advanced Biopolymers Srl | Verfahren zur herstellung von zwei- und dreidimensionalen polymergerüsten |
JP2006296896A (ja) | 2005-04-22 | 2006-11-02 | Tohoku Univ | コラーゲン薄膜シート、その製造方法、それを用いた再建方法、および自己組織再生誘導型人工皮膚・粘膜 |
US20060255053A1 (en) | 2005-05-16 | 2006-11-16 | Empire Industrial Corp. | Sealable container |
CA2611081C (en) | 2005-06-03 | 2016-05-31 | Egalet A/S | A drug delivery system for delivering active substances dispersed in a dispersion medium |
US20060282138A1 (en) | 2005-06-10 | 2006-12-14 | Ohshin Mlp Co., Ltd. | Exothermic structure that is directly applied to skin |
WO2007001926A2 (en) | 2005-06-24 | 2007-01-04 | Hyperbranch Medical Technology, Inc. | Low-swelling hydrogel sealants for wound repair |
JP4421542B2 (ja) | 2005-09-29 | 2010-02-24 | 株式会社東芝 | 燃料電池システム用触媒構造体および燃料電池システム |
US20070086958A1 (en) | 2005-10-14 | 2007-04-19 | Medafor, Incorporated | Formation of medically useful gels comprising microporous particles and methods of use |
WO2007059144A1 (en) | 2005-11-15 | 2007-05-24 | Surmodics, Inc. | Ultrasonic nozzles for applying two-component coatings |
US20070264130A1 (en) | 2006-01-27 | 2007-11-15 | Phluid, Inc. | Infusion Pumps and Methods for Use |
EP2338547B1 (en) | 2006-02-09 | 2013-04-17 | DEKA Products Limited Partnership | Fluid delivery systems |
US20070250007A1 (en) | 2006-04-23 | 2007-10-25 | Nilimedix Ltd. | Drug Delivery Device With Air Pressure Spring And Safety Valve |
WO2007133699A2 (en) | 2006-05-12 | 2007-11-22 | Gore Enterprise Holding, Inc. | Immobilized biologically active entities having a high degree of biological activity following mecanical manipulation or sterilization |
US8496953B2 (en) | 2006-05-12 | 2013-07-30 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having a high degree of biological activity following sterilization |
US9114194B2 (en) | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
CA2652559A1 (en) | 2006-05-18 | 2007-11-29 | Biobalance Llc | Biotherapeutic compositions and uses thereof |
AU2007267338B2 (en) | 2006-05-31 | 2013-04-04 | Baxter Healthcare S.A. | Method for directed cell in-growth and controlled tissue regeneration in spinal surgery |
KR100751046B1 (ko) | 2006-07-21 | 2007-08-21 | 이가식품(주) | 수용성 키토산을 함유하는 당면의 제조방법 |
TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
WO2008019126A2 (en) | 2006-08-04 | 2008-02-14 | Stb Lifesaving Technologies, Inc. | Process for production of solid wound dressing |
US20080095830A1 (en) | 2006-10-20 | 2008-04-24 | Van Holten Robert W | Method for making a dressing |
WO2008057600A2 (en) | 2006-11-09 | 2008-05-15 | Kci Licensing Inc. | Porous bioresorbable dressing conformable to a wound and methods of making same |
CN102552967B (zh) * | 2006-12-15 | 2015-08-12 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
US20100143447A1 (en) | 2006-12-19 | 2010-06-10 | Ferrosan A/S | Wound or tissue dressing comprising lactic acid bacteria |
WO2008090554A2 (en) | 2007-01-22 | 2008-07-31 | Elutex Ltd. | Modified conductive surfaces prepared by electrografting of diazonium salts |
US8703634B2 (en) | 2007-02-21 | 2014-04-22 | The Regents Of The University Of California | Hemostatic compositions and methods of use |
US20080311172A1 (en) | 2007-04-25 | 2008-12-18 | Schapira Jay N | Programmed-release, nanostructured biological construct |
EP2167041B1 (en) | 2007-06-15 | 2012-11-07 | Zymogenetics, Inc. | Stabilized thrombin compositions |
US20090075891A1 (en) | 2007-08-06 | 2009-03-19 | Macphee Martin | Methods and dressings for sealing internal injuries |
US20090087569A1 (en) | 2007-09-27 | 2009-04-02 | Fenchem Enterprises Ltd. | Methods for Preparing Highly Stable Hyaluronic Acid |
JP2011500237A (ja) | 2007-10-30 | 2011-01-06 | バクスター・インターナショナル・インコーポレイテッド | 内臓または体腔壁の欠陥を治療するための再生性の生体機能性コラーゲン生物基質の使用 |
WO2009091683A1 (en) | 2008-01-17 | 2009-07-23 | Becton, Dickinson And Company | Valve for mixing of substances |
US8642831B2 (en) | 2008-02-29 | 2014-02-04 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
ES2421642T3 (es) | 2008-03-03 | 2013-09-04 | Omrix Biopharmaceuticals Ltd | Una esponja de gelatina que comprende un ingrediente activo, su preparación y uso |
EP2265728A4 (en) | 2008-04-03 | 2012-08-01 | Zymogenetics Inc | HEMOSTATIC MICROSPHERES |
EP2282718A2 (en) | 2008-04-25 | 2011-02-16 | Jay N. Schapira | Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration |
AU2009246306B2 (en) | 2008-05-14 | 2014-09-25 | Biolyph, Llc | Reagent preparation and dispensing device and methods for the same |
US20100048758A1 (en) | 2008-08-22 | 2010-02-25 | Boston Scientific Scimed, Inc. | Lubricious coating composition for devices |
DE102009004828B4 (de) | 2009-01-13 | 2010-12-09 | Lts Lohmann Therapie-Systeme Ag | Injektor mit verdrängbarem Stopfenteil |
JP5088342B2 (ja) | 2009-03-25 | 2012-12-05 | 三菱マテリアル株式会社 | 多孔質焼結体の製造方法 |
US20100256671A1 (en) | 2009-04-07 | 2010-10-07 | Biomedica Management Corporation | Tissue sealant for use in noncompressible hemorrhage |
US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
MX2011013795A (es) | 2009-06-16 | 2012-04-30 | Baxter Int | Esponja hemostatica. |
US8429831B2 (en) | 2009-09-04 | 2013-04-30 | Abbott Cardiovascular Systems Inc. | Drug-eluting coatings applied to medical devices by spraying and drying to remove solvent |
US20110092918A1 (en) | 2009-10-19 | 2011-04-21 | Ferrosan A/S | Malleable tip for applying an agent to a target site |
KR20120125465A (ko) | 2010-01-08 | 2012-11-15 | 프로피브릭스 비.브이. | 건조 분말 피브린 실란트 |
JP2011212182A (ja) | 2010-03-31 | 2011-10-27 | Terumo Corp | プレフィルドシリンジ |
ES2682302T3 (es) * | 2010-06-01 | 2018-09-19 | Baxter International Inc | Proceso para la producción de composiciones hemostáticas secas y estables |
KR101967085B1 (ko) | 2010-06-01 | 2019-04-08 | 백스터 인터내셔널 인코포레이티드 | 건조 및 안정한 지혈 조성물의 제조 방법 |
BR112012030463B1 (pt) | 2010-06-01 | 2021-08-24 | Baxter International Inc. | Processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, kit para administrar uma composição hemostática, e, grânulos revestidos com trombina |
CN106390186B (zh) * | 2011-04-27 | 2020-07-03 | 比奥马普公司 | 止血组合物 |
RU2013155713A (ru) | 2011-07-06 | 2015-08-20 | Профибрикс Бв | Составы для лечения ран |
EP2766060B1 (en) | 2011-10-11 | 2022-11-23 | Baxter International Inc. | Hemostatic composition |
MX346958B (es) | 2011-10-11 | 2017-04-06 | Baxter Int | Composición hemostatica. |
KR102102002B1 (ko) | 2011-10-11 | 2020-04-20 | 백스터 인터내셔널 인코포레이티드 | 지혈 조성물 |
US20130108671A1 (en) | 2011-10-27 | 2013-05-02 | Baxter Healthcare S.A. | Hemostatic compositions |
BR112014018127B1 (pt) | 2012-01-23 | 2021-03-23 | Bee Sight Limited | Seringa |
WO2013131520A2 (en) | 2012-03-06 | 2013-09-12 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
RU2636240C2 (ru) | 2012-06-12 | 2017-11-21 | Ферросан Медикал Дивайсиз А/С | Сухая гемостатическая композиция |
CA2893064C (en) | 2012-12-07 | 2021-05-04 | Baxter International Inc. | Hemostatic foam |
JP6390873B2 (ja) | 2013-06-21 | 2018-09-19 | フェッローサン メディカル ディバイス エー/エス | 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ |
RU2678592C1 (ru) | 2013-12-11 | 2019-01-30 | Ферросан Медикал Дивайсиз А/С | Сухая композиция, содержащая компонент, улучшающий экструзию |
BR112017007466B1 (pt) | 2014-10-13 | 2021-03-02 | Ferrosan Medical Devices A/S | método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca |
JP6747650B2 (ja) | 2014-12-24 | 2020-08-26 | フェロサン メディカル デバイシーズ エイ/エス | 第1の物質と第2の物質を保持し混合するためのシリンジ |
US10918796B2 (en) | 2015-07-03 | 2021-02-16 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
IL242984A0 (en) | 2015-12-08 | 2016-02-29 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, their preparation and how to use them |
-
2013
- 2013-06-12 RU RU2014153857A patent/RU2636240C2/ru active
- 2013-06-12 CN CN201380030067.3A patent/CN104349797B/zh active Active
- 2013-06-12 CA CA2874290A patent/CA2874290C/en active Active
- 2013-06-12 JP JP2015516467A patent/JP6394916B2/ja active Active
- 2013-06-12 BR BR112014030962A patent/BR112014030962A2/pt not_active Application Discontinuation
- 2013-06-12 EP EP13732818.3A patent/EP2825216B1/en active Active
- 2013-06-12 AU AU2013275758A patent/AU2013275758B2/en active Active
- 2013-06-12 EP EP15180748.4A patent/EP2977066A3/en not_active Withdrawn
- 2013-06-12 WO PCT/DK2013/050191 patent/WO2013185776A1/en active Application Filing
-
2014
- 2014-10-17 US US14/516,728 patent/US9265858B2/en active Active
- 2014-11-27 IN IN10106DEN2014 patent/IN2014DN10106A/en unknown
-
2015
- 2015-06-19 HK HK15105866.3A patent/HK1205008A1/xx unknown
- 2015-12-28 US US14/980,254 patent/US9999703B2/en active Active
-
2018
- 2018-04-26 US US15/963,795 patent/US10799611B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2825216A1 (en) | 2015-01-21 |
RU2636240C2 (ru) | 2017-11-21 |
US20180243468A1 (en) | 2018-08-30 |
HK1205008A1 (en) | 2015-12-11 |
US10799611B2 (en) | 2020-10-13 |
US20160158407A1 (en) | 2016-06-09 |
EP2825216B1 (en) | 2015-08-19 |
AU2013275758B2 (en) | 2015-03-12 |
WO2013185776A1 (en) | 2013-12-19 |
AU2013275758A1 (en) | 2015-01-29 |
RU2014153857A (ru) | 2016-08-10 |
US9265858B2 (en) | 2016-02-23 |
US9999703B2 (en) | 2018-06-19 |
EP2977066A2 (en) | 2016-01-27 |
IN2014DN10106A (ja) | 2015-08-21 |
BR112014030962A2 (pt) | 2017-06-27 |
JP2015519152A (ja) | 2015-07-09 |
CA2874290C (en) | 2020-02-25 |
CN104349797A (zh) | 2015-02-11 |
EP2977066A3 (en) | 2016-07-27 |
US20150037314A1 (en) | 2015-02-05 |
CN104349797B (zh) | 2017-10-27 |
CA2874290A1 (en) | 2013-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6394916B2 (ja) | 乾燥止血組成物 | |
JP6390873B2 (ja) | 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ | |
JP6489485B2 (ja) | 押し出し増強因子を含んでいる乾燥組成物 | |
JP6726852B2 (ja) | 止血および創傷治癒に使用するための乾燥組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141224 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160531 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160930 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170404 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170704 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20171212 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20180312 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180413 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180717 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180814 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6394916 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |