ES2421642T3 - Una esponja de gelatina que comprende un ingrediente activo, su preparación y uso - Google Patents

Una esponja de gelatina que comprende un ingrediente activo, su preparación y uso

Info

Publication number
ES2421642T3
ES2421642T3 ES09717197T ES09717197T ES2421642T3 ES 2421642 T3 ES2421642 T3 ES 2421642T3 ES 09717197 T ES09717197 T ES 09717197T ES 09717197 T ES09717197 T ES 09717197T ES 2421642 T3 ES2421642 T3 ES 2421642T3
Authority
ES
Spain
Prior art keywords
sponge
active ingredient
preparation
peptide
ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09717197T
Other languages
English (en)
Inventor
Israel Nur
Liliana Bar
Guy Tomer
Eyal Sheetrit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals Ltd
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Application granted granted Critical
Publication of ES2421642T3 publication Critical patent/ES2421642T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Abstract

Un método para fabricar una esponja de gelatina reticulada mejorada que comprende un ingrediente activo de proteína o péptido que comprende los pasos de: a) proporcionar una esponja de gelatina reticulada; b) aplicar homogéneamente un líquido que comprende un ingrediente activo de proteína o péptido a sólo una superficie de dicha esponja, en donde el volumen de la ingesta de líquido es igual a o menos del 5% del volumen de la esponja en a); y c) secar la esponja, en donde dicho paso de secado se lleva a cabo por horno de vacío, obteniendo de este modo una esponja de gelatina reticulada flexible, seca que comprende una capa estable de ingrediente activo de proteína o péptido en la mencionada superficie de la esponja.
ES09717197T 2008-03-03 2009-03-02 Una esponja de gelatina que comprende un ingrediente activo, su preparación y uso Active ES2421642T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3317408P 2008-03-03 2008-03-03
EP08102227 2008-03-03
PCT/IL2009/000236 WO2009109963A1 (en) 2008-03-03 2009-03-02 A gelatin sponge comprising an active ingredient, its preparation and use

Publications (1)

Publication Number Publication Date
ES2421642T3 true ES2421642T3 (es) 2013-09-04

Family

ID=39577821

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09717197T Active ES2421642T3 (es) 2008-03-03 2009-03-02 Una esponja de gelatina que comprende un ingrediente activo, su preparación y uso

Country Status (11)

Country Link
US (4) US8475812B2 (es)
EP (1) EP2252335B1 (es)
JP (1) JP5615719B2 (es)
KR (1) KR101541702B1 (es)
CN (1) CN101970021B (es)
AU (1) AU2009220808B2 (es)
CA (1) CA2717571C (es)
DK (1) DK2252335T3 (es)
ES (1) ES2421642T3 (es)
HK (1) HK1149724A1 (es)
WO (1) WO2009109963A1 (es)

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EP2252335B1 (en) 2008-03-03 2013-04-24 Omrix Biopharmaceuticals Ltd. A gelatin sponge comprising an active ingredient, its preparation and use
BR112012015029A2 (pt) 2009-12-22 2017-06-27 Lifebond Ltd matriz reticulada, método para controlar a formação de uma matriz, método ou matriz, método para vedar um tecido contra vazamento de um fluído corporal, agente hemostático ou vedante cirúrgico, composição para vedar um ferimento, uso da composição, composição para um veículo para entrega localizada de fármaco, composição para engenharia de tecido, e método para modificar uma composição
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CN103702645B (zh) 2011-05-24 2015-10-21 武田奈科明有限公司 卷起的胶原蛋白载体
JP6241624B2 (ja) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス 止血ペーストを収容する加圧容器
ES2610572T3 (es) 2012-05-24 2017-04-28 Takeda As Envase
EP2854735B1 (en) 2012-05-24 2019-02-13 Takeda AS Apparatus and process for providing a coiled collagen carrier
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KR102223275B1 (ko) * 2012-12-03 2021-03-09 옴릭스 바이오파머슈티컬스 리미티드 트롬빈 용액 및 이의 사용 방법
WO2014202760A2 (en) 2013-06-21 2014-12-24 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
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KR101495449B1 (ko) * 2013-11-12 2015-02-23 전북대학교산학협력단 혈소판 패치의 제조 방법
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin
EP3470094B1 (en) 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
CN103772753B (zh) * 2014-01-08 2016-05-04 天津科技大学 一种大豆肽卡拉胶可食复合膜及其制备方法
JP6726852B2 (ja) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス 止血および創傷治癒に使用するための乾燥組成物
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
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EP2252335B1 (en) 2008-03-03 2013-04-24 Omrix Biopharmaceuticals Ltd. A gelatin sponge comprising an active ingredient, its preparation and use

Also Published As

Publication number Publication date
US9427490B2 (en) 2016-08-30
EP2252335B1 (en) 2013-04-24
US20140120151A1 (en) 2014-05-01
CA2717571C (en) 2016-08-23
HK1149724A1 (en) 2011-10-14
US20160136322A1 (en) 2016-05-19
AU2009220808A1 (en) 2009-09-11
US8981058B2 (en) 2015-03-17
CN101970021A (zh) 2011-02-09
KR20100132966A (ko) 2010-12-20
CN101970021B (zh) 2015-01-28
DK2252335T3 (da) 2013-07-08
US20150196680A1 (en) 2015-07-16
KR101541702B1 (ko) 2015-08-04
JP5615719B2 (ja) 2014-10-29
US20110045034A1 (en) 2011-02-24
EP2252335A1 (en) 2010-11-24
WO2009109963A1 (en) 2009-09-11
JP2011513388A (ja) 2011-04-28
AU2009220808B2 (en) 2014-01-16
CA2717571A1 (en) 2009-09-11
US8475812B2 (en) 2013-07-02

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