NO20050537L - Anvendelse av HMGB1 i behandlingen av vevsskade og/eller for a fremme vevsreparasjon - Google Patents
Anvendelse av HMGB1 i behandlingen av vevsskade og/eller for a fremme vevsreparasjonInfo
- Publication number
- NO20050537L NO20050537L NO20050537A NO20050537A NO20050537L NO 20050537 L NO20050537 L NO 20050537L NO 20050537 A NO20050537 A NO 20050537A NO 20050537 A NO20050537 A NO 20050537A NO 20050537 L NO20050537 L NO 20050537L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- tissue
- hmgb1
- promote
- hmgbl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Marine Sciences & Fisheries (AREA)
- General Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
Abstract
Det beskrives et preparat omfattende en effektiv mengde HMGBl-protein eller fimksjonelle deler derav, eller HMGBl-ekspresjonsvektorer for behandlingen av vevsskade og/eller for å fremme vevsreparasjon og regenerering. Det er videre beskrevet et preparat omfattende en effektiv mengde av en antagonist av HMGBl-proteinet for behandlingen av bivirkninger indusert gjeimom nekrotisk vev, slik som rekruttering og aktivering av myeloidceller, tap av barrierefimksjonen til endotelia, ødem.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39399402P | 2002-07-03 | 2002-07-03 | |
PCT/IT2003/000265 WO2004004763A2 (en) | 2002-07-03 | 2003-04-29 | Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20050537L true NO20050537L (no) | 2005-02-01 |
Family
ID=30115667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20050537A NO20050537L (no) | 2002-07-03 | 2005-02-01 | Anvendelse av HMGB1 i behandlingen av vevsskade og/eller for a fremme vevsreparasjon |
Country Status (14)
Country | Link |
---|---|
US (1) | US20060035851A1 (no) |
EP (1) | EP1519957B1 (no) |
JP (1) | JP2005537253A (no) |
KR (1) | KR20050054907A (no) |
CN (1) | CN1671742A (no) |
AT (1) | ATE424416T1 (no) |
AU (1) | AU2003228099A1 (no) |
CA (1) | CA2491321A1 (no) |
DE (1) | DE60326453D1 (no) |
IL (1) | IL166022A0 (no) |
MX (1) | MXPA05000302A (no) |
NO (1) | NO20050537L (no) |
RU (1) | RU2005102593A (no) |
WO (1) | WO2004004763A2 (no) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
US7151082B2 (en) | 1999-02-11 | 2006-12-19 | The Feinstein Institute For Medical Research | Antagonists of HMG1 for treating inflammatory conditions |
US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
AU2004272607B2 (en) | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
AU2005264185A1 (en) * | 2004-07-20 | 2006-01-26 | Centro Cardiologico Monzino S.P.A. - Irccs | Use of HMGB1 for wound healing |
US8129130B2 (en) | 2004-10-22 | 2012-03-06 | The Feinstein Institute For Medical Research | High affinity antibodies against HMGB1 and methods of use thereof |
EP1812065A4 (en) | 2004-10-22 | 2009-09-02 | Medimmune Inc | HIGH AFFINITY ANTIBODIES AGAINST HMGB1 AND METHODS OF USE |
US7795314B2 (en) | 2005-06-01 | 2010-09-14 | Cytokine Pharmasciences, Inc. | Protective role of semapimod in necrotizing enterocolitis |
WO2007031100A1 (en) * | 2005-09-14 | 2007-03-22 | Ostini, Marco | Active immunotherapy of life-threatening systemic inflammation |
CA2631212A1 (en) | 2005-11-28 | 2007-07-05 | Medimmune, Llc | Antagonists of hmgb1 and/or rage and methods of use thereof |
US7829097B2 (en) | 2006-02-06 | 2010-11-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of HMGB1 for protection against ischemia reperfusion injury |
JP3882090B1 (ja) * | 2006-05-19 | 2007-02-14 | 国立大学法人 岡山大学 | 脳血管攣縮抑制剤 |
AU2014200688C1 (en) * | 2006-10-30 | 2016-04-21 | Genomix Co., Ltd. | Pharmaceuticals that promote functional regeneration of damaged tissues |
DK2055308T3 (en) * | 2006-10-30 | 2017-07-17 | Genomix Co Ltd | PHARMACEUTICALS FOR PROMOTING FUNCTIONAL REGENERATION OF DAMAGED TISSUE |
TW200902063A (en) | 2007-02-15 | 2009-01-16 | Univ Kumamoto | Therapeutic agent comprising antibody capable of specifically binding to human hmgb-1 as active ingredient |
JP5660889B2 (ja) * | 2008-04-30 | 2015-01-28 | 株式会社ジェノミックス | 末梢循環への骨髄由来多能性幹細胞動員薬 |
RU2010148785A (ru) * | 2008-04-30 | 2012-06-10 | Дженомикс Ко., Лтд. (Jp) | Фармацевтическое средство для стимуляции функциональной регенерации поврежденной ткани |
US9919010B2 (en) | 2008-04-30 | 2018-03-20 | Genomix Co., Ltd. | Method for collecting functional cells in vivo with high efficiency |
AU2010312537A1 (en) | 2009-10-28 | 2012-05-17 | Genomix Co., Ltd. | Tissue-regeneration promoter using recruitment of bone marrow mesenchymal stem cells and/or pluripotent stem cells in blood |
RU2012157399A (ru) * | 2010-06-18 | 2014-07-27 | КсайберСайенс ГмбХ | Пептиды в качестве активных агентов для стабилизации биологических барьеров |
CN102375064A (zh) * | 2010-08-26 | 2012-03-14 | 杭州华得森生物技术有限公司 | 用酶联免疫法检测人体中hmga2含量的体外诊断试剂盒 |
WO2012030919A2 (en) * | 2010-09-01 | 2012-03-08 | Thomas Jefferson University | Composition and method for muscle repair and regeneration |
ES2684718T3 (es) | 2011-04-26 | 2018-10-04 | StemRIM Inc. | Péptido para inducir regeneración de tejido y uso del mismo |
WO2014016417A1 (en) * | 2012-07-26 | 2014-01-30 | Ospedale San Raffaele Srl | Hmgb1 variants and uses thereof |
CA2889275C (en) * | 2012-10-25 | 2021-06-15 | Katsuto Tamai | Novel method for treating cardiac infarction using hmgb1 fragment |
RU2649069C2 (ru) * | 2012-10-25 | 2018-04-02 | Дженомикс Ко., Лтд. | Новый способ лечения повреждения спинного мозга с применением фрагмента hmgb1 |
CN103316378B (zh) * | 2013-06-27 | 2014-07-16 | 重庆大学 | 一种hmgb 1修饰的骨组织工程支架材料及其制备方法 |
KR102365492B1 (ko) | 2015-04-22 | 2022-02-18 | 삼성전자주식회사 | 웨어러블 기기 |
RU2768186C2 (ru) | 2015-12-11 | 2022-03-23 | Рупрехт-Карлс-Университет Гейдельберг | Комбинированные лекарственные средства, содержащие модуляторы pkm2 и hmgb1 |
CN109310741A (zh) * | 2016-04-29 | 2019-02-05 | 阿拉伊姆药品公司 | 用于预防和治疗与组织损伤相关的疾病和障碍的组织保护肽 |
CN106244589A (zh) * | 2016-08-01 | 2016-12-21 | 中国人民解放军第四军医大学 | 靶向hmgb1基因的rna干扰片段及其应用 |
TWI805565B (zh) * | 2017-01-27 | 2023-06-21 | 日商斯德武利姆股份有限公司 | 心肌病、陳舊性心肌梗塞及慢性心臟衰竭的治療藥物 |
BR112019021230A2 (pt) | 2017-04-25 | 2020-06-02 | Shionogi & Co., Ltd. | Peptídeos, composições que os compreende e uso dos mesmos |
WO2019107530A1 (ja) | 2017-12-01 | 2019-06-06 | 株式会社ステムリム | 炎症性腸疾患の治療薬 |
CN111381050B (zh) * | 2020-04-21 | 2023-06-20 | 南通大学 | Reg3β/ HMGB1环路调控EAM小鼠巨噬细胞再编程的实验方法 |
WO2023037562A1 (ja) * | 2021-09-07 | 2023-03-16 | 国立大学法人大阪大学 | 肺炎の治療薬 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19548122A1 (de) * | 1995-12-21 | 1997-06-26 | Joern Prof Dr Bullerdiek | Nukleinsäuresequenzen von Genen der High Mobility Group Proteine sowie Verwendungen derselben |
US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
US6610713B2 (en) * | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
CA2440480A1 (en) * | 2001-03-15 | 2002-09-26 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions |
US7754217B2 (en) | 2001-03-16 | 2010-07-13 | Bio3 Research Srl | HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
CA2447576C (en) * | 2001-05-15 | 2014-04-08 | North Shore-Long Island Jewish Research Institute | Use of hmg fragments as anti-inflammatory agents |
-
2003
- 2003-04-29 CA CA002491321A patent/CA2491321A1/en not_active Abandoned
- 2003-04-29 AU AU2003228099A patent/AU2003228099A1/en not_active Abandoned
- 2003-04-29 JP JP2004519162A patent/JP2005537253A/ja active Pending
- 2003-04-29 AT AT03725585T patent/ATE424416T1/de not_active IP Right Cessation
- 2003-04-29 KR KR1020057000004A patent/KR20050054907A/ko not_active Application Discontinuation
- 2003-04-29 DE DE60326453T patent/DE60326453D1/de not_active Expired - Lifetime
- 2003-04-29 EP EP03725585A patent/EP1519957B1/en not_active Expired - Lifetime
- 2003-04-29 WO PCT/IT2003/000265 patent/WO2004004763A2/en active Application Filing
- 2003-04-29 US US10/519,427 patent/US20060035851A1/en not_active Abandoned
- 2003-04-29 RU RU2005102593/15A patent/RU2005102593A/ru not_active Application Discontinuation
- 2003-04-29 CN CNA038178796A patent/CN1671742A/zh active Pending
- 2003-04-29 MX MXPA05000302A patent/MXPA05000302A/es not_active Application Discontinuation
-
2004
- 2004-12-28 IL IL16602204A patent/IL166022A0/xx unknown
-
2005
- 2005-02-01 NO NO20050537A patent/NO20050537L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2004004763A3 (en) | 2004-02-26 |
CA2491321A1 (en) | 2004-01-15 |
CN1671742A (zh) | 2005-09-21 |
WO2004004763A2 (en) | 2004-01-15 |
DE60326453D1 (de) | 2009-04-16 |
AU2003228099A1 (en) | 2004-01-23 |
RU2005102593A (ru) | 2005-10-10 |
US20060035851A1 (en) | 2006-02-16 |
JP2005537253A (ja) | 2005-12-08 |
ATE424416T1 (de) | 2009-03-15 |
EP1519957B1 (en) | 2009-03-04 |
IL166022A0 (en) | 2006-01-15 |
KR20050054907A (ko) | 2005-06-10 |
EP1519957A2 (en) | 2005-04-06 |
MXPA05000302A (es) | 2005-08-19 |
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