US5306501A - Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers - Google Patents

Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers Download PDF

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US5306501A
US5306501A US07791119 US79111991A US5306501A US 5306501 A US5306501 A US 5306501A US 07791119 US07791119 US 07791119 US 79111991 A US79111991 A US 79111991A US 5306501 A US5306501 A US 5306501A
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copolymer
aqueous
polyoxyalkylene
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Tacey X. Viegas
Lorraine E. Reeve
Robert S. Levinson
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MDV Technologies Inc
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Mediventures Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/944Gel

Abstract

Isotonic, iso-osmotic, pH balanced thermoreversible gels are ideal medical devices or vehicles for drug injection into the body of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the osmolality in the liquid state.

Description

This is a continuation-in-part of U.S. Ser. No. 07/517,277, filed May 1, 1990, now abandoned.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates to drug delivery systems and medical devices comprising an aqueous, injectable gel.

2. Description of the Prior Art

Over the years, methods have been developed to achieve the efficient delivery of a therapeutic drug to a mammalian body part requiring pharmaceutical treatment. Use of an aqueous liquid which can be applied at room temperature as a liquid but which forms a semisolid gel when warmed to body temperature has been utilized as a vehicle for drug delivery since such a system combines ease of application with greater retention at the site requiring treatment than would be the case if the aqueous composition were not converted to a gel as it is warmed to mammalian body temperature. In U.S. Pat. No. 4,188,373, PLURONIC® polyols are used in aqueous compositions to provide thermally gelling aqueous systems. Adjusting the concentration of the polymer provides the desired sol-gel transition temperature, that is, the lower the concentration of polymer, the higher the sol-gel transition temperature, after crossing a critical concentration minimum, below which a gel will not form.

In U.S. Pat. Nos. 4,474,751; '752; '753; and 4,478,822 drug delivery systems are described which utilize thermosetting gels; the unique feature of these systems is that both the gel transition temperature and/or the rigidity of the gel can be modified by adjustment of the MV-023C CIP pH and/or the ionic strength, as well as by the concentration of the polymer.

Other patents disclosing pharmaceutical compositions which rely upon an aqueous gel composition as a vehicle for the application of the drug are U.S. Pat. Nos. 4,883,660; 4,767,619; 4,511,563; and 4,861,760. Thermosetting gel systems are also disclosed in U.S. Pat. No. 4,911,926 for application to injured tissue of the thoracic or peritoneal cavities.

While the prior art is silent with respect to aqueous drug delivery vehicles and isotonicity thereof, osmotic drug delivery systems are disclosed in U.S. 4,439,196 which utilize a multi-chamber compartment for holding osmotic agents, adjuvants, enzymes, drugs, pro-drugs, pesticides, and the like. These materials are enclosed by semipermeable membranes so as to allow the fluids within the chambers to diffuse into the environment into which the osmotic drug delivery system is in contact. The drug delivery device can be sized for oral ingestion, implantation, rectal, vaginal, or ocular insertion for delivery of a drug or other beneficial substance. Since this drug delivery device relies on the permeability of the semipermeable membranes to control the rate of delivery of the drug, the drugs or other pharmaceutical preparations, by definition, are not isotonic with mammalian blood.

SUMMARY OF THE INVENTION

Drug delivery vehicles, drug delivery compositions, medical devices and processes for their use are disclosed. The pharmaceutical compositions contain pharmacologically active medicaments useful for injection intramuscularly or subcutaneously into the mammalian body. The use of the compositions of the invention without a drug component is indicated where an aqueous gel is desirable to separate injured tissue in a manner more gentle than can be accomplished using surgical instruments. The compositions of the invention provide a physiologically acceptable media having a buffered pH and an osmotically balanced vehicle so as to, preferably, provide an isotonic mixture having iso-osmotic and pH properties which are similar to bodily fluids, such as blood plasma. The pH and osmotic pressure of such bodily fluids is about pH 7.4 and 290 MOSM/kg. In addition, the pharmaceutical composition of the invention are, optionally, sterilized so as to insure that the pharmaceutical compositions of the invention do not provide a source of infection.

Polyphase systems are also useful and may contain non-aqueous solutes, non-aqueous solvents, and other non-aqueous additives. Homogeneous, polyphase systems can contain such additives as water insoluble high molecular weight fatty acids and alcohols, fixed oils, volatile oils and waxes, mono-, di-, and triglycerides, and synthetic, water insoluble polymers without altering the functionality of the system.

In a preferred embodiment, the compositions of the invention can be injected into the mammalian body as a low viscosity liquid at ambient temperatures which, upon contact with the mammalian body, forms a semisolid gel having a very high viscosity.

A wide variety of polyoxyalkylene block copolymers are suitable for the preparation of the pharmaceutical compositions of the invention. Generally, it is necessary to adjust the preferred polyoxyalkylene block copolymer concentration in aqueous solution so as to obtain the desired sol-gel transition temperature in order that the compositions can be provided as low viscosity liquids at ambient temperature, yet form semisolid gels at mammalian body temperatures. In addition to the concentration of the polymer, other suitable excipients must be added to provide the desired osmotic properties (i.e., iso-osmotic, hyperosmotic, or hypo-osmotic).

The useful polymers which provide the sol-gel characteristics of the pharmaceutical compositions of the invention are, preferably, polyoxyalkylene block copolymers.

DESCRIPTION OF THE DRAWING

The drawing provides a curve showing the osmolality in the solution state of a polyoxyalkylene copolymer, identified as Poloxamer 407, at various concentrations in a 0.1 molar TRIS hydrochloride buffer. The scale at the left side of the plot indicates the osmolality in the liquid state, while the scale on the right side of the plot indicates the osmolality of the composition when in the gelled state. Thus, curve A provides a graph showing the osmolality in the liquid state at various concentrations in grams per liter of the Poloxamer 407. Curve B shows the osmolality calculated for the gel state, assuming that the gelled Poloxamer 407 molecules do not contribute to the osmotic force. Curve A is obtained by measuring the effect upon the freezing point depression of the Poloxamer 407 solutions in comparison with a sample of purified water (deionized water). It is noted that the curves were obtained by fitting the osmolality and concentration of polymer to the quadratic equation, Y=A +Bx+Cx2, where Y is osmolality, x is concentration, and A, B, and C are constants. The relationship of concentration to osmolality is nonlinear in this system.

DETAILED DESCRIPTION OF THE INVENTION

It has been found that aqueous pharmaceutical vehicles containing a polyoxyalkylene block copolymer, which have the unique feature, in a preferred embodiment, of being liquid at ambient temperatures and transitioning at mammalian body temperatures to a semisolid gel, can be made isotonic or iso-osmotic (or hyperosmotic or hypoosmotic) and adjusted to the pH of mammlian body fluids, such as blood plasma. The pH and osmotic pressure of such bodily fluids are 7.4 and 290 mOsm/kg, respectively. It is, accordingly, advantageous to deliver by injection a pharmacologically active medicament to an area of the mammalian body requiring pharmacological treatment under pH and osmotic pressure conditions which match those of bodily fluids. The medical devices and pharmaceutical compositions of the invention are optionally provided in a sterile condition.

In addition to those polyoxyalkylene polymers described above, which are suitable in the formation of the pharmaceutical compositions of the invention, other polyxyalkylene polymers which form gels at low concentrations in water are suitable. One such polymer is described in U.S. Pat. No. 4,810,503, incorporated herein by reference. These polymers are prepared by capping conventional polyether polyols with an alpha-olefin epoxide having an average of about 20 to about 45 carbon atoms, or mixtures thereof. Aqueous solutions of these polymers gel in combination with surfactants, which can be ionic or nonionic. The combination of the capped polyether polymers and the surfactants provide aqueous gels at low concentrations of the capped polymer and surfactant, which generally do not exceed 10% by weight total. Detailed methods of preparing these aqueous gels are disclosed in U.S. Pat. No. 4,810,503. Preparation of said aqueous gels is generally described below. Preferred surfactants for use in preparing these gels are also disclosed in said patent.

A conventional copolymer polyether polyol is prepared by preparing block or heteric intermediate polymers of ethylene oxide and at least one lower alkylene oxide having 3 to 4 carbon atoms as intermediates. These are then capped with the alpha-olefin epoxide to prepare the polymers. Ethylene oxide homopolymers capped with said alpha-olefin oxides are also useful as intermediates.

The heteric copolymer intermediate is prepared by mixing ethylene oxide and at least one lower alkylene oxide having 3 to 4 carbon atoms with a low molecular weight active hydrogen-containing compound initiator having at least two active hydrogens and preferably, 2 to 6 active hydrogen atoms such as a polyhydric alcohol, containing from 2 to 10 carbon atoms and from 2 to 6 hydroxyl groups and heating said mixture to a temperature in the range of about 50° C. to 150° C., preferably from about 30 psig to 90 psig.

A block copolymer intermediate is prepared by reacting either the ethylene oxide or said alkylene oxide having 3 to 4 carbon atoms with said active hydrogen-containing compound followed by reaction with the other alkylene oxide.

The ethylene oxide and the alkylene oxides having from 3 to 4 carbon atoms are used in said intermediates in amounts so that the resulting polyether product will contain at least 10 percent and preferably about 70 to 90 percent, by weight, ethylene oxide residue. The ethylene oxide with said active hydrogen-containing compound. The reaction conditions for preparing the block copolymer and ethylene oxide homopolymer intermediates are similar to those for the heteric copolymer intermediate. The temperature and pressure are maintained in the above ranges for a period of about one hour to ten hours, preferably one to three hours.

The alpha-olefin oxides which are utilized to modify the conventional polyether intermediate of the prior art are those oxides and the commercially available mixtures thereof generally containing an average of about 20 to 45, preferably about 20 to 30, carbon atoms. The amount of alpha-olefin required to obtain the more efficient capped polyethers is generally about 0.3 to 10 percent, preferably about 4 to 8 percent, of the total weight of the polyethers.

Since the preparation of heteric and block copolymers of alkylene oxides and ethylene oxide homopolymers are well known in the art, further description of the preparation of said polymers is unnecessary. Further details of the preparation of heteric copolymers of lower alkylene oxide can be obtained in U.S. Pat. No. 3,829,506, incorporated herein by reference. Further information on the preparation of block copolymers of lower alkylene oxides can be obtained in U.S. Pat. Nos. 3,535,307; 3,036,118; 2,979,578; 2,677,700; and 2,675,619 incorporated herein by reference.

The surfactants may be ionic or nonionic and many surfactants and types of surfactants may be employed. While all surfactants may not be effective in the preparation of the isotonic gels of the instant invention, the fact that many are effective makes it a simple matter for one skilled in the art to select such surfactant with a minimum of trial and error.

The amounts of capped polyether polymer and surfactant may be as little as 1.0 percent by weight or less of each depending on the type and amount of the other component. There appears to be no maximum amount of either component then that dictated by economic considerations. However, the total amount of capped polymer and surfactant would generally not exceed 10 percent by weight.

Generally, the polyoxyalkylene block copolymers of the invention are defined as follows:

a polyoxyalkylene block copolyer of the formula

[Y(A).sub.n --E--H].sub.x                                  (I)

wherein A is a polyoxyalkylene moiety having an oxygen/carbon atom ratio of less than 0.5 x is at least 2, Y is derived from water or an organic compound containing x reactive hydrogen atoms, E is a polyoxyethylene moiety constituting at least 60% by weight of the copolymer, n has a value such that the minimum molecular weight is between about 500 to about 900, as determined by the hydroxyl number of an intermediate,

Y[(A).sub.n --H].sub.x                                     (II)

and the total average molecular weight of the copolymer is at least about 5,000.

Preferred are polyoxyalkylene block copolymers of the formula:

HO(C.sub.2 H.sub.4 O).sub.b (C.sub.4 H.sub.8 O).sub.a (C.sub.2 H.sub.4 O).sub.b                                                  (III)

wherein in III, a is an integer such that the hydrophobe base represented by (C4 H8 O)a has a molecular weight of at least about 500 as determined by hydroxyl number, the polyoxyethylene chain constituting at least about 70% by weight of the copolymer, and the copolymer having a total average molecular weight of at least 5,000 and most preferably at least 15,000, or

HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H                                                (IV)

wherein in IV, a is an integer such that the hydrophobe base represented by (C3 H6 O)a has a molecular weight of at least about 900 average molecular weight, as determined by hydroxyl number, the polyoxyethylene chain constituting at least about 70% by weight of the copolymer, and the copolymer having a total average molecular weight of at least 5,000 and most preferably at least about 15,000, or ##STR1## wherein in V, a and b are integers such that the copolymer has a hydrophobe molecular weight of at least about 1500, a hydrophile content of at least about 70%, and a total average molecular weight of at least 5,000 and most preferably at least about 15,000.

Most preferred are the polyoxyalkylene block copolymers of the formula: ##STR2## so that the methyl group is bonded to the carbon having a single hydrogen. These polymers are present, preferably, in the amount of about 10 to about 30% by weight of the total weight of the compositions of the invention.

The drug delivery vehicle of the present invention will contain from about 0.01% to about 60% by weight of the medicament or pharmaceutical from about 10 to about 50% of the polymer and from 80% to about 20% water. In special situations, however, the amounts may be varied to increase or decrease the dosage schedule.

If desired, the drug delivery vehicle may also contain preservatives, cosolvents, suspending agents, viscosity enhancing agents, ionic-strength and osmolality adjustors and other excipients in addition to buffering agents. Suitable water soluble preservatives which may be employed in the drug delivery vehicle are sodium bisulfite, sodium thiosulfate, ascorbate, benzalkonium chloride, chorobutanol, thimerosal, phenylmercuric borate, parabens, benzyl alcohol, phenylethanol and others. These agents may be present, generally, in amounts of about 0.001% to about 5% by weight and, preferably, in the amount of about 0.01 to about 2% by weight.

Suitable water soluble buffering agents are alkali or alkaline earth metal carbonates, phosphates, bicarbonates, citrates, borates, acetates, succinates and the like, such as sodium phosphate, citrate, borate, acetate, bicarbonate, carbonate and tromethamine (TRIS). These agents are present in amounts sufficient to maintain the pH of the system at 7.4±0.2 and preferably, 7.4. As such, the buffering agent can be as much as 5% on a weight basis of the total composition.

Many pharmaceutically active materials may be delivered by the drug delivery system of this invention. Preferably, the drug, or pharmaceutical, is water soluble. Some drugs will show greater solubility in the aqueous polymer system than others. Cosolvents can be used to enhance drug solubility, however, some drugs may be insoluble. These can often be suspended in the polymer vehicle with the aid of suitable suspending or viscosity enhancing agents.

Typically as stated previously, the present liquid drug delivery device can contain from about 0.01 to about 60% of the medicament, or pharmaceutical, on a weight to weight basis. Thus, from one gram of the liquid composition containing about 1 ml of solution, one would obtain about 0.1 mg to about 600 mg of drug.

Representative buffering agents or salts useful in maintaining the pH at about 7.4±0.2 are alkali or alkaline earth metal carbonates, chlorides, sulfates, phosphates, bicarbonates, citrates, borates, acetates, succinates and tromethamine (TRIS). Representative preservatives are sodium bisulfite, sodium thiosulfate, ascorbate, benzalkonium chloride, chlorobutanol, thimerosal, phenylmercuric borate, parabens, benzyl alcohol and phenyethanol.

With respect to the use of the pharmaceutical compositions of the invention for injection either subcutaneously or intramuscularly, the following are useful classes of drugs: antibacterial substances, antihistamines and decongestants, anti-inflammatories, antiparasitics, mydriatics, antiglaucoma drugs, carbonic anhydrase inhibitors, ophthalmic diagnostic agents, ophthalmic agents used as adjuvants in surgery, chelating agents, immunosuppressive agents, antimetabolites, antivirals, local anesthetics, antifungal, amoebicidal, or trichomonacidal agents, analgesics, antiarthritics, antiasthmatics, anticoagulants, anticonvulsants, antidepressants, antidiabetics, antieoplastics, antipsychotics, antihypertensives and muscle relaxants. Representative antibacterial substances are beta-lactam antibiotics, tetracyclines, chloramphenicol, neomycin, gramicidin, bacitracin, sulfonamides, aminoglycoside antibiotics, tobramycin, nitrofurazone, nalidixic acid and analogs and the antimicrobial combination of fluoroalanine/pentizidone. Representative antihistaminics and decongestants are perilamine, chlorpheniramine, tetrahydrozoline and antazoline. Representative anti-inflammatory drugs are cortisone, hydrocortisone, betamethasone, dexamethasone, fluocortolone, prednisolone, triamcinolone, indomethacin, sulindac and its salts and corresponding sulfide. A representative antiparasitic compound is invermectin. Representative antiviral compounds are acyclovir and interferon. Representative analgesic drugs are diflunisal, aspirin or acetaminophen. Representative antiarthritics are phenylbutazone, indomethacin, silindac, its salts and corresponding sulfide, dexamethasone, ibuprofen, allopurinol, oxyphenbutazone or probenecid. Representative astiasthma drugs are theophylline, ephedrine, beclomethasone dipropionate and epinephrine. Representative anticoagulants are heparin, bishydroxycoumarin, and warfarin. Representative anticonvulsants are diphenylhydantoin and diazepam. Rpresentative antidepressants are amitriptyline, chlordiazepoxide, perphenazine, protriptyline, imipramine and doxepin. Representative antidiabetics are insulin, somatostatin and its analogs, tolbutamide, tolazamide, acetohexamide and chlorpropamide. Representative antineoplastics are adriamcycin, fluorouracil, methotrexate and asparaginase. Representative antipsychotics are prochlorperazine, lithium carbonate, lithium citrate, thioridazine, molindone, fluphenazine, trifluoperazine, perphenazine, amitriptyline and trilupromazine. Representative anithypertensives are spironolactone, methyldopa, hydralazine, clonidine, chlorothiazide, deserpidine, timolol, propranolol, metoprolal, prazosin hydrochloride and reserpine. Representative muscle relaxants are succinylcholine chloride, dantrolene, cyclobenzaprine, methocarbamol and diazepam.

The preparation of the pharmaceutical drug delivery compositions of the invention are described below. The examples which follow were prepared according with the following preparation procedure. Since the polymer systems of this invention dissolve more completely at reduced temperatures, the preferred methods of solubilization are to add the required amount of polymer to the amount of water to be used. Generally after wetting the polymer by shaking, the mixture is capped and placed in a cold chamber or in a thermostatic container at about 0° C. to 10° C. in order to dissolve the polymer. The mixture can be stirred or shaken to bring about a more rapid solution of the polymer. The pharmacologically active medicaments and various additives such as buffers, salts, and preservatives can subsequently be added and dissolved. In some instances the pharmocologically active substance must be suspended since it is insoluble in water. The pH of 7.4±0.2 is obtained by the addition of appropriate buffering agents.

The following examples illustrate the various aspects of the invention but are not intended to limit its scope. Where not otherwise specified throughout this specification and claims, temperatures are given in degrees centigrade and parts, percentages, and proportions are by weight.

EXAMPLE 1

This Example formulation describes a composition of the invention characterized as iso-osmotic, sterile, and having a pH of 7.4±0.2. An aqueous solution was made of a polyoxyethylene-polyoxypropylene block copolymer having the structure generically shown above as Formula VI and having a polyoxypropylene hydrophobe base average molecular weight of about 4,000, a total average molecular weight of about 11,500, and containing oxyethylene groups in the amount of about 70% by weight of the total weight of copolymer. This copolymer (Formula VI below) is sold under the trademark PLURONIC® F-127 (also known as Poloxamer 407) by the BASF Corporation, Parsippany, N.J. A solution in TRIS hydrochloride buffer was made by dissolving said polymer and sodium alginate in cold (4° C.) buffer to give a concentration of 25% by weight in accordance with the cold process procedure described above for forming aqueous solutions. More specific solution procedures are described in "Artificial Skin I Preparation and Properties of PLURONIC F-127 Gels For Treatment of Burns", Journal of Biomedical Material Research 6, 527, 1974, incorporated herein by reference. The block copolymer has the formula: ##STR3## This formulation forms the basis for the Figure in which curve A is the determined osmolality of the formulation in the liquid state and curve B is the calculated osmolality of the formulation in the gelled state. It is noted that generally the formulation will gel at mammalian body temperatures only at concentrations of polymer exceeding 17%.

The formulation was sterilized by autoclaving at 121° C. and 15 psi for 15 minutes. The pH before autoclaving was found to be 7.3 and after autoclaving remained the same. The osmolality in the gelled state before autoclaving was determined to be 290±10 and after autoclaving 298±10 mOsm/kg. The gel strength (viscosity) in centipoise as measured at 37 degrees C using a Brookfield (spindle and cup) viscometer at 20 revolutions per minute was greater than 44,000 before autoclaving and greater than 44,000 after autoclaving.

EXAMPLE 2

This is an example of an iso-osmotic, isotonic, pH balanced, thermoreversible system, in which the active ingredient is dissolved.

The following antibiotic formulation was prepared to contain 3.5 mg of neomycin sulfate and 10,000 units of polymyxin B sulfate per gram of antibiotic formulation solution. The antibiotic formulation was prepared as follows:

______________________________________Ingredient           Percent by Weight______________________________________Neomycin sulfate     0.55Polymyxin B sulfate  0.12Glycerin             0.7Poloxamer 407 (BASF) 19.0Methyl/Propyl Parabens (9:1)                0.1TRIS hydrochloride buffer (0.1 molar)                79.53______________________________________

The formulation was prepared by dissolving the methyl/propyl paraben preservative, neomycin sulfate and polymyxin B sulfate by stirring in the required amount of TRIS hydrochloride buffer. These ingredients in a glass beaker were placed on ice and the Poloxamer 407 was added to the beaker slowly while stirring. After the Poloxamer 407 was completely dissolved, the formulation was stored at 4° C. The product obtained was characterized as clear, colorless and exhibiting gelation at the temperature of mammalian skin (33°±2° C.). The formulation was sterilized by autoclaving for 15 minutes at 15 psi and 121° C. The pH and osmolality of the product were as follows: pH 7.5 and osmolality of approximately 650 mOsm/kg in the liquid state. In the gelled state, the pH and osmolality of the preparation would be expected to be 7.5 and 290 mOsm/kg, respectively.

EXAMPLE 3

This is an example of an iso-osmotic, isotonic, pH balanced, thermoreversible system, in which the active ingredient is dispersed.

The following antibacterial formulation was prepared to contain one percent by weight of silver sulfadiazine.

______________________________________Ingredient         Percent by Weight______________________________________Silver Sulfadiazine              1.0Glycerin           0.25Xanthan Gum        0.33Poloxamer 407 (BASF)              18.66Methyl/Propyl Parabens (9:1)              0.1TRIS Maleate Buffer (0.05 molar)              79.72______________________________________

The formulation was prepared by levigating silver sulfadiazine and glycerin in a glass mortar. Weighed amounts of xanthan gum paste (2.5% in a buffer portion) were added with continued levigation. The Poloxamer 407 and the methyl/propyl paraben preservatives were added to the other buffer portion, in accordance with the cold process described above, to prepare an aqueous solution. This solution was weighed and mixed with a weighed amount of levigated mix. The mixing was achieved with a homogenizer and in a nitrogen environment. The product obtained was characterized as milky-white and exhibiting gelation at the temperature of mammalian skin (33°±2° C.). The pH of the product was 7.32 and the measured osmolality in the liquid state was 573 mOsm/Kg. The calculated osmolality in the gelled state was approximately 290 mOsm/kg, assuming that the gelled Poloxamer 407 molecules do not contribute to the osmotic force.

EXAMPLE 4 AND 5

Examples 2 and 3 are repeated substituting 2% by weight of polymer #2, as described in U.S. Pat. No. 4,810,503 and 4% by weight of surfactant #1, as described therein. The balance of the percentage of Poloxamer 407 used in Example 2 and 3 is made up with TRIS hydrochloride buffer. These formulations form gels at room temperature. Substantially similar pH and osmolality results were obtained.

While this invention has been described with reference to certain specific embodiments, it will be recognized by those skilled in the art that many variations are possible without departing from the scope and spirit of the invention, and it will be understood that it is intended to cover all changes and modifications of the invention, disclosed herein for the purpose of illustration, which do not constitute departures from the spirit and scope of the invention.

Claims (20)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
1. A process for treating a condition requiring the use of a medical device or pharmacological treatment which comprises injection into the body of a mammal a hyperosmotic, iso-osmotic, or hypo-osmotic aqueous composition, which is a liquid at room temperature or below and an aqueous gel with a desired osmolality at mammalian body temperature, said aqueous composition containing:
(1) about 20% to about 80% by weight of water and
(2) about 10% to about 50% by weight of a polyoxyalkylene block copolymer of formula
Y[(A).sub.n --E--H].sub.x                                  (I)
wherein A is a polyoxyalkylene moiety having an oxygen/carbon atom ratio of less than 0.5, x is at least 1, Y is derived from water or an organic compound containing x reactive hydrogen atoms, E is a polyoxyethylene moiety, n has a value such that the minimum molecular weight of A is between about 500, as determined by the hydroxyl number of an intermediate of formula
Y[(A).sub.n --H].sub.x                                     (II)
and the total average molecular weight of the polyoxyalkylene block copolymer is at least about 5,000;
wherein the osmolality of the composition in the liquid state is adjusted to achieve the desired value of the osmolality of the aqueous gel by assuming that the polyoxyalkylene block copolymer does not contribute to the osmolality in the aqueous gel.
2. The process of claim 1 wherein said Y in said polyoxyalkylene block copolymer is derived from a water soluble organic compound having 1 to about 6 carbon atoms and wherein said aqueous composition further contains a pharmacologically effective amount of a drug selected from the group consisting of antibacterials, decongestants, anti-inflammatories, miotics, anticholinergics, mydriatics, antiglaucoma drugs, carbonic anhydrase inhibitors, ophthalmic diagnostic agents, ophthalmic agents used as adjuvants in surgery, chelating agents, antivirals, local anesthetics, antifungals, amoebicidals, trichomonocidals, analgesics, immunosuppressive agents and antimetabolites.
3. The process of claim 1, wherein said y in said polyoxyalkylene block copolymer is derived from a water soluble organic compound having 1 to about 6 carbon atoms and wherein said aqueous composition further contains a pharmacologically effective amount of a drug selected from the group consisting of antiparasitics and antihistamines.
4. The process of claim 1 wherein said polyoxyalkylene moiety is derived from an alkylene oxide selected from the group consisting of butylene oxide, propylene oxide, and mixtures thereof and Y is derived from an organic compound selected from the group consisting of propylene glycol, glycerin, pentaerythritol, trimethylolpropane, ethylenediamine and mixtures thereof.
5. The process of claim 4 wherein said copolymer is a polyoxyethylene-polyoxypropylene block copolymer wherein said polyoxyethylene moiety constitutes at least about 70% by weight of the copolymer, the average molecular weight of A is at least about 1,200, and the total molecular weight of the copolymer is at least about 10,000.
6. The process of claim 5 wherein the intermediate of Formula II is prepared by initiation with propylene glycol and has a molecular weight of at least about 1,500.
7. The process of claim 6 wherein said polyoxyalkylene block copolymer has the formula
HO(C.sub.2 H.sub.4 O).sub.b (C.sub.4 H.sub.8 O).sub.a (C.sub.2 H.sub.4 O).sub.b H                                                (III)
wherein a and b are integers such that the hydrophobe base represented by (C4 H8 O)a has an average molecular weight of at least about 500 as determined by hydroxyl number, the polyoxyethylene chain constituting at least about 70% by weight of the polyoxyalkylene block copolymer, and the polyoxyalkylene block copolymer has a total average molecular weight of at least 5,000; or has the formula
HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H                                                (IV)
wherein a and b are integers such that the hydrophobe base represented by (C3 H6 O)a has an average molecular weight of at least about 900, as determined by hydroxyl number, the polyoxyethylene chain constituting at least about 70% by weight of the polyoxyalkylene block copolymer, and the polyoxyalkylene block copolymer having a total average molecular weight of at least 5,000; or has the formula ##STR4## wherein a and b are integers such that the polyoxyalkylene block copolymer has an average hydrophobe molecular weight of at least 1,500, a hydrophile content of at least about 70% by weight, and a total average molecular weight of at least about 5,000.
8. The process of claim 7 wherein said polyoxyalkylene block copolymer is ##STR5## present in the amount of about 10 to about 40% by weight of the total weight of said composition.
9. The process of claim 7 wherein said polyalkylene block copolymer is present in the amount of about 15 to about 30% by weight in said aqueous composition and wherein the pH is maintained at 7.4±0.2 and the osmolality in the aqueous gel is maintained at about 290 mOsm/kg.
10. The process of claim 7, wherein said total average molecular weight of said polyoxyalkylene block copolymer is at least about 15,000.
11. A process for treating a condition requiring the use of a medical device or pharmacological treatment which comprises injection into the body of a mammal a hyperosmotic, iso-osmotic, or hypo-osmotic aqueous composition which is a liquid at room temperature or below and an aqueous gel with a desired osmolality at mammalian body temperature, said aqueous composition containing
(1) a surfactant and
(2) a polyoxyalkylene polyether, said surfactant and said polyoxyalkylene polyether being present in a combined total amount not exceeding about 10 percent by weight and said polyoxyalkylene polyether having a molecular weight of about 10,000 to about 100,000 and being selected from the group consisting of
(A) polyoxyalkylene polyethers prepared by reacting ethylene oxide and at least one lower alkylene oxide having 3 to 4 carbon atoms with at least one active hydrogen-containing compound having from 3 to 10 carbon atoms and from 3 to 6 active hydrogens to prepare a heteric or block copolymer intermediate and further reacting said copolymer intermediate with at least one alpha-olefin oxide having an average carbon chain length of about 20 to 45 aliphatic carbon atoms and wherein said alpha-olefin oxide is present in the amount of about 0.3 to 10 percent by weight based upon the total weight of said polyether and
(B) polyoxyalkylene polyethers prepared by reacting ethylene oxide with at least one active hydrogen-containing compound having from 2 to 10 carbon atoms and from 2 to 6 active hydrogens to prepare a homopolymer intermediate and further reacting said homopolymer intermediate with at least one alpha-olefin oxide having an average carbon chain length of about 20 to 45 aliphatic carbon atoms and wherein said alpha-olefin oxide is present in the amount of about 0.3 to 10 percent by weight based on the total weight of said polyether;
wherein the osmolality of the aqueous composition in the liquid state is adjusted to achieve the desired value of the osmolality of the aqueous gel by assuming that the polyoxyalkylene polyether does not contribute to the osmolality in the aqueous gel.
12. The process of claim 11 wherein said aqueous composition further contains a pharmacologically effective amount of a drug selected from the group consisting of antibacterials, decongestants, anti-inflammatories, miotics, anticholinergics, mydriatics, antiglaucoma drugs, carbonic anhydrase inhibitors, ophthalmic diagnostic agents, ophthalmic agents used as adjuvants in surgery, chelating agents, antivirals, local anesthetics, antifungals, amoeticidals, trichomonocidals, analgesics, immunosuppressive agents and antimetabolites, wherein the surfactant is present at about 1% by weight or more, the polyoxyalkylene polyether is present at about 1% by weight or more, such that the combined amount of surfactant and polyoxyalkylene polyether is less than about 10% by weight, and the drug is present at about 0.01% to 60% by weight based on the total weight of the aqueous composition.
13. The process of claim 11, wherein said aqueous composition further contains a pharmacologically effective amount of a drug selected from the group consisting of antiparasitics and antihistamines.
14. The process of claim 11 wherein said polyether is prepared using a heteric copolymer intermediate and wherein the pH is maintained at 7.4±0.2 and the osmolality of the aqueous gel is maintained at about 290 mOsm/kg.
15. The process of claim 14 wherein said polyether is prepared using an alpha-olefin oxide having an average carbon chain length of about 20 to 30 carbon atoms, present in the amount of about 0.3 to 10 percent of the total weight of said polyether.
16. The process of claim 15 wherein said polyether contains a proportion of ethylene oxide residue to the residue of said lower alkylene oxide of about 70 to about 90 percent by weight of ethylene oxide residue to about 30 to about 10 percent by weight of said lower alkylene oxide residue.
17. The process of claim 16 wherein said polyether is prepared using propylene oxide as the lower alkylene oxide.
18. The process of claim 11 wherein said polyether is prepared suing a block copolymer intermediate.
19. The process of claim 18 wherein said polyether is prepared using an alpha-olefin oxide having an average carbon chain length of about 20 to 30 carbon atoms, present in the amount of about 0.3 to 10 percent of the total weight of said polyether.
20. The process of claim 11 wherein said polyether is polyether (B).
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