IL242984A0 - Thrombin microcapsules, preparation and uses thereof - Google Patents

Thrombin microcapsules, preparation and uses thereof

Info

Publication number
IL242984A0
IL242984A0 IL242984A IL24298415A IL242984A0 IL 242984 A0 IL242984 A0 IL 242984A0 IL 242984 A IL242984 A IL 242984A IL 24298415 A IL24298415 A IL 24298415A IL 242984 A0 IL242984 A0 IL 242984A0
Authority
IL
Israel
Prior art keywords
preparation
thrombin
microcapsules
thrombin microcapsules
Prior art date
Application number
IL242984A
Other languages
Hebrew (he)
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Priority to IL242984A priority Critical patent/IL242984A0/en
Publication of IL242984A0 publication Critical patent/IL242984A0/en
Priority to JP2018529535A priority patent/JP6918799B2/en
Priority to EP16822750.2A priority patent/EP3386487A1/en
Priority to BR112018011504A priority patent/BR112018011504A2/en
Priority to PCT/IL2016/000024 priority patent/WO2017098493A1/en
Priority to CN201680072297.XA priority patent/CN108366967B/en
Priority to AU2016367536A priority patent/AU2016367536B2/en
Priority to CA3007900A priority patent/CA3007900A1/en
Priority to KR1020187018990A priority patent/KR20180091035A/en
Priority to IL259185A priority patent/IL259185B/en
Priority to US16/184,321 priority patent/US10869912B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
IL242984A 2015-10-29 2015-12-08 Thrombin microcapsules, preparation and uses thereof IL242984A0 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL242984A IL242984A0 (en) 2015-12-08 2015-12-08 Thrombin microcapsules, preparation and uses thereof
KR1020187018990A KR20180091035A (en) 2015-12-08 2016-12-01 Thrombin microcapsule
PCT/IL2016/000024 WO2017098493A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
EP16822750.2A EP3386487A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
BR112018011504A BR112018011504A2 (en) 2015-12-08 2016-12-01 thrombin microcapsules
JP2018529535A JP6918799B2 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
CN201680072297.XA CN108366967B (en) 2015-12-08 2016-12-01 Thrombin Microcapsules
AU2016367536A AU2016367536B2 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
CA3007900A CA3007900A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
IL259185A IL259185B (en) 2015-12-08 2018-05-07 Thrombin microcapsules
US16/184,321 US10869912B2 (en) 2015-10-29 2018-11-08 Thrombin microcapsules, preparation and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL242984A IL242984A0 (en) 2015-12-08 2015-12-08 Thrombin microcapsules, preparation and uses thereof

Publications (1)

Publication Number Publication Date
IL242984A0 true IL242984A0 (en) 2016-02-29

Family

ID=59012760

Family Applications (2)

Application Number Title Priority Date Filing Date
IL242984A IL242984A0 (en) 2015-10-29 2015-12-08 Thrombin microcapsules, preparation and uses thereof
IL259185A IL259185B (en) 2015-12-08 2018-05-07 Thrombin microcapsules

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL259185A IL259185B (en) 2015-12-08 2018-05-07 Thrombin microcapsules

Country Status (9)

Country Link
EP (1) EP3386487A1 (en)
JP (1) JP6918799B2 (en)
KR (1) KR20180091035A (en)
CN (1) CN108366967B (en)
AU (1) AU2016367536B2 (en)
BR (1) BR112018011504A2 (en)
CA (1) CA3007900A1 (en)
IL (2) IL242984A0 (en)
WO (1) WO2017098493A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2657955C2 (en) 2012-03-06 2018-06-18 Ферросан Медикал Дивайсиз А/С Pressurised container containing haemostatic paste
RU2636240C2 (en) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Dry haemostatic composition
CN105358071B (en) 2013-06-21 2018-07-31 弗罗桑医疗设备公司 The dry composition of vacuum expansion and syringe for retaining the dry composition
WO2015086028A1 (en) 2013-12-11 2015-06-18 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
CN107206165B (en) 2014-12-24 2020-10-23 弗罗桑医疗设备公司 Syringe for holding and mixing first and second substances
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
BR112020011034A2 (en) 2017-12-29 2020-11-17 Baxter International Inc. spray-dried thrombin and methods for using and making spray-dried thrombin
EP3790600B1 (en) 2018-05-09 2023-12-27 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
IL263679A (en) * 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and ingredients for preventing tissue adhesion
CN116392394B (en) * 2023-05-18 2025-09-26 合肥芯能相变新材料科技有限公司 A probiotic microcapsule preparation device and preparation method thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
EP0713388B1 (en) 1993-08-06 1999-05-06 Opperbas Holding B.V. A method for high loading of vesicles with biopolymeric substances
WO1997044015A1 (en) * 1996-05-17 1997-11-27 Andaris Limited Microparticles and their use in wound therapy
EP0856317A1 (en) 1997-01-31 1998-08-05 Omrix Biopharmaceuticals S.A. A stabilized mixture comprising fibrinogen
US6121232A (en) 1997-01-31 2000-09-19 Omrix Biopharmaceuticals Sa Stabilized mixture comprising fibrinogen
GB9727102D0 (en) 1997-12-22 1998-02-25 Andaris Ltd Microparticles and their therapeutic use
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
WO2002095019A1 (en) 2001-05-21 2002-11-28 Omrix Biopharmaceuticals S.A. Removal of plasmin(ogen) from protein solutions
BRPI0621537B8 (en) 2006-04-10 2021-05-25 Ethicon Inc absorbable and reinforced multi-layer hemostatic dressing for dressing, and manufacturing method
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
AU2009236960A1 (en) * 2008-04-16 2009-10-22 The Chemo-Sero-Therapeutic Research Institute Method of producing thrombin-immobilized bioabsorbable sheet preparation
US9827205B2 (en) * 2008-12-12 2017-11-28 Mallinckrodt Pharma Ip Trading D.A.C. Dry powder fibrin sealant
WO2011083154A1 (en) * 2010-01-08 2011-07-14 Profibrix Bv Dry powder fibrin sealant
WO2011151386A1 (en) * 2010-06-01 2011-12-08 Baxter International Inc. Process for making dry and stable hemostatic compositions
EP2575775B1 (en) * 2010-06-01 2018-04-04 Baxter International Inc. Process for making dry and stable hemostatic compositions
US9212357B2 (en) * 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
BR112015017463A8 (en) 2013-03-07 2017-11-28 Profibrix Bv POWDER FORMULATION
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd Dry pad comprising thrombin and pectin

Also Published As

Publication number Publication date
IL259185B (en) 2021-07-29
KR20180091035A (en) 2018-08-14
AU2016367536A1 (en) 2018-05-17
WO2017098493A1 (en) 2017-06-15
JP6918799B2 (en) 2021-08-11
BR112018011504A2 (en) 2018-12-04
JP2019501893A (en) 2019-01-24
CA3007900A1 (en) 2017-06-15
EP3386487A1 (en) 2018-10-17
CN108366967B (en) 2021-03-12
CN108366967A (en) 2018-08-03
IL259185A (en) 2018-07-31
AU2016367536B2 (en) 2021-12-02

Similar Documents

Publication Publication Date Title
ZA201708561B (en) Microcapsules
SG10202109688XA (en) Novel lactobacillus having various functions, and use thereof
GB201512203D0 (en) Agents,uses and methods
EP3206781A4 (en) High strength microcapsules
IL242984A0 (en) Thrombin microcapsules, preparation and uses thereof
IL290114A (en) Pharmaceutical composition, preparation and uses thereof
GB201512215D0 (en) Agents,uses and methods
GB201408673D0 (en) Medicaments,uses and methods
ZA201801052B (en) Combinations and uses thereof
EP3414313A4 (en) Microcapsule
HUE056175T2 (en) Pharmaceutical compositions, preparation and uses thereof
IL252397A0 (en) Pharmaceutical composition, preparation and uses thereof
LT3229843T (en) Pharmaceutical composition, preparation and uses thereof
IL254241A0 (en) Etv2 and uses thereof
HUE047919T2 (en) Bioassimilable protein-melanin complex, preparation and uses
PL3386988T3 (en) Novel dihydropyranopyrimidinone derivatives, and use thereof
IL249073B (en) Chitin-glucan complex, its preparation, and uses
PL3122184T3 (en) Clomazone microcapsules, their preparation and use
HK1262546A1 (en) Thrombin microcapsules
GB201518375D0 (en) Agents,uses and methods
GB201512211D0 (en) Agents, uses and methods
GB201518198D0 (en) Lanthanum and uses thereof
HUP1500514A2 (en) New ppv1 strain and uses thereof
GB201502489D0 (en) Cells, preparation, uses, methods and components
AU2015900732A0 (en) Garments and Utilisation