IL259185B - Thrombin microcapsules - Google Patents

Thrombin microcapsules

Info

Publication number
IL259185B
IL259185B IL259185A IL25918518A IL259185B IL 259185 B IL259185 B IL 259185B IL 259185 A IL259185 A IL 259185A IL 25918518 A IL25918518 A IL 25918518A IL 259185 B IL259185 B IL 259185B
Authority
IL
Israel
Prior art keywords
thrombin
microcapsules
thrombin microcapsules
Prior art date
Application number
IL259185A
Other languages
Hebrew (he)
Other versions
IL259185A (en
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Publication of IL259185A publication Critical patent/IL259185A/en
Publication of IL259185B publication Critical patent/IL259185B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
IL259185A 2015-12-08 2018-05-07 Thrombin microcapsules IL259185B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562264432P 2015-12-08 2015-12-08
IL242984A IL242984A0 (en) 2015-12-08 2015-12-08 Thrombin microcapsules, preparation and uses thereof
PCT/IL2016/000024 WO2017098493A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules

Publications (2)

Publication Number Publication Date
IL259185A IL259185A (en) 2018-07-31
IL259185B true IL259185B (en) 2021-07-29

Family

ID=59012760

Family Applications (2)

Application Number Title Priority Date Filing Date
IL242984A IL242984A0 (en) 2015-10-29 2015-12-08 Thrombin microcapsules, preparation and uses thereof
IL259185A IL259185B (en) 2015-12-08 2018-05-07 Thrombin microcapsules

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL242984A IL242984A0 (en) 2015-10-29 2015-12-08 Thrombin microcapsules, preparation and uses thereof

Country Status (9)

Country Link
EP (1) EP3386487A1 (en)
JP (1) JP6918799B2 (en)
KR (1) KR20180091035A (en)
CN (1) CN108366967B (en)
AU (1) AU2016367536B2 (en)
BR (1) BR112018011504A2 (en)
CA (1) CA3007900A1 (en)
IL (2) IL242984A0 (en)
WO (1) WO2017098493A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104159527B (en) 2012-03-06 2017-04-12 弗罗桑医疗设备公司 Pressurized container containing haemostatic paste
CN104349797B (en) 2012-06-12 2017-10-27 弗罗桑医疗设备公司 Dry hemostatic composition
CA2912357C (en) 2013-06-21 2019-12-31 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
JP6489485B2 (en) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ／エス Dry composition containing an extrusion enhancing factor
CN106999621B (en) 2014-10-13 2020-07-03 弗罗桑医疗设备公司 Dry composition for hemostasis and wound healing
BR112017013565B1 (en) 2014-12-24 2021-12-28 Ferrosan Medical Devices A/S SYRINGE FOR RETENTION AND MIXING OF FIRST AND SECOND SUBSTANCES
CN107771093B (en) 2015-07-03 2021-06-15 弗罗桑医疗设备公司 Syringe for mixing two components and for maintaining vacuum under storage conditions
CN111787958A (en) 2017-12-29 2020-10-16 巴克斯特国际公司 Spray-dried thrombin and methods of using and making spray-dried thrombin
JP7395113B2 (en) 2018-05-09 2023-12-11 フェロサン メディカル デバイシーズ エイ／エス Method of preparing a hemostatic composition
IL263679A (en) * 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and compositions for preventing tissue adhesion

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
EP0815852A1 (en) 1993-08-06 1998-01-07 Opperbas Holding B.V. A method for high loading of vesicles with biopolymeric substances
AU702955B2 (en) * 1996-05-17 1999-03-11 Quadrant Healthcare (Uk) Limited Microparticles and their use in wound therapy
US6121232A (en) 1997-01-31 2000-09-19 Omrix Biopharmaceuticals Sa Stabilized mixture comprising fibrinogen
EP0856317A1 (en) 1997-01-31 1998-08-05 Omrix Biopharmaceuticals S.A. A stabilized mixture comprising fibrinogen
GB9727102D0 (en) 1997-12-22 1998-02-25 Andaris Ltd Microparticles and their therapeutic use
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
EE05485B1 (en) 2001-05-21 2011-10-17 Omrix Biopharmaceuticals S.A. Removal of plasma (i) n (ogen) from protein solutions
WO2007117237A1 (en) 2006-04-10 2007-10-18 Ethicon, Inc. A reinforced absorbable multilayered hemostatic wound dressing and method of making
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
CA2721335A1 (en) * 2008-04-16 2009-10-22 Ryoichi Kawamura Process for preparing bioabsorbable sheet preparation holding thrombin
US9827205B2 (en) * 2008-12-12 2017-11-28 Mallinckrodt Pharma Ip Trading D.A.C. Dry powder fibrin sealant
WO2011083154A1 (en) 2010-01-08 2011-07-14 Profibrix Bv Dry powder fibrin sealant
KR101814841B1 (en) * 2010-06-01 2018-01-03 백스터 인터내셔널 인코포레이티드 Process for making dry and stable hemostatic compositions
EP2575770B1 (en) * 2010-06-01 2017-03-22 Baxter International Inc Process for making dry and stable hemostatic compositions
US9212357B2 (en) * 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
AU2014224594B2 (en) 2013-03-07 2018-05-10 Mallinckrodt Pharma Ip Trading D.A.C. Powder formulation comprising thrombin and fibrinogen
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd Dry pad comprising thrombin and pectin

Also Published As

Publication number Publication date
AU2016367536A1 (en) 2018-05-17
IL242984A0 (en) 2016-02-29
IL259185A (en) 2018-07-31
KR20180091035A (en) 2018-08-14
AU2016367536B2 (en) 2021-12-02
CN108366967A (en) 2018-08-03
JP2019501893A (en) 2019-01-24
BR112018011504A2 (en) 2018-12-04
CN108366967B (en) 2021-03-12
JP6918799B2 (en) 2021-08-11
CA3007900A1 (en) 2017-06-15
WO2017098493A1 (en) 2017-06-15
EP3386487A1 (en) 2018-10-17

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