IL242984A0 - מיקרוקפסולות של תרומבין, הכנתן ואופן שימושן - Google Patents

מיקרוקפסולות של תרומבין, הכנתן ואופן שימושן

Info

Publication number
IL242984A0
IL242984A0 IL242984A IL24298415A IL242984A0 IL 242984 A0 IL242984 A0 IL 242984A0 IL 242984 A IL242984 A IL 242984A IL 24298415 A IL24298415 A IL 24298415A IL 242984 A0 IL242984 A0 IL 242984A0
Authority
IL
Israel
Prior art keywords
preparation
thrombin
microcapsules
thrombin microcapsules
Prior art date
Application number
IL242984A
Other languages
English (en)
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Priority to IL242984A priority Critical patent/IL242984A0/he
Publication of IL242984A0 publication Critical patent/IL242984A0/he
Priority to JP2018529535A priority patent/JP6918799B2/ja
Priority to EP16822750.2A priority patent/EP3386487A1/en
Priority to CN201680072297.XA priority patent/CN108366967B/zh
Priority to BR112018011504A priority patent/BR112018011504A2/pt
Priority to AU2016367536A priority patent/AU2016367536B2/en
Priority to PCT/IL2016/000024 priority patent/WO2017098493A1/en
Priority to CA3007900A priority patent/CA3007900A1/en
Priority to KR1020187018990A priority patent/KR20180091035A/ko
Priority to IL259185A priority patent/IL259185B/he
Priority to US16/184,321 priority patent/US10869912B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
IL242984A 2015-10-29 2015-12-08 מיקרוקפסולות של תרומבין, הכנתן ואופן שימושן IL242984A0 (he)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL242984A IL242984A0 (he) 2015-12-08 2015-12-08 מיקרוקפסולות של תרומבין, הכנתן ואופן שימושן
KR1020187018990A KR20180091035A (ko) 2015-12-08 2016-12-01 트롬빈 마이크로캡슐
BR112018011504A BR112018011504A2 (pt) 2015-12-08 2016-12-01 microcápsulas de trombina
EP16822750.2A EP3386487A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
CN201680072297.XA CN108366967B (zh) 2015-12-08 2016-12-01 凝血酶微胶囊
JP2018529535A JP6918799B2 (ja) 2015-12-08 2016-12-01 トロンビンマイクロカプセル
AU2016367536A AU2016367536B2 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
PCT/IL2016/000024 WO2017098493A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
CA3007900A CA3007900A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
IL259185A IL259185B (he) 2015-12-08 2018-05-07 מיקרו קפסולות של תרומבין
US16/184,321 US10869912B2 (en) 2015-10-29 2018-11-08 Thrombin microcapsules, preparation and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL242984A IL242984A0 (he) 2015-12-08 2015-12-08 מיקרוקפסולות של תרומבין, הכנתן ואופן שימושן

Publications (1)

Publication Number Publication Date
IL242984A0 true IL242984A0 (he) 2016-02-29

Family

ID=59012760

Family Applications (2)

Application Number Title Priority Date Filing Date
IL242984A IL242984A0 (he) 2015-10-29 2015-12-08 מיקרוקפסולות של תרומבין, הכנתן ואופן שימושן
IL259185A IL259185B (he) 2015-12-08 2018-05-07 מיקרו קפסולות של תרומבין

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL259185A IL259185B (he) 2015-12-08 2018-05-07 מיקרו קפסולות של תרומבין

Country Status (9)

Country Link
EP (1) EP3386487A1 (he)
JP (1) JP6918799B2 (he)
KR (1) KR20180091035A (he)
CN (1) CN108366967B (he)
AU (1) AU2016367536B2 (he)
BR (1) BR112018011504A2 (he)
CA (1) CA3007900A1 (he)
IL (2) IL242984A0 (he)
WO (1) WO2017098493A1 (he)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
EP3010419B1 (en) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
BR112016013322B1 (pt) 2013-12-11 2020-07-21 Ferrosan Medical Devices A/S métodos para preparação de uma composição seca e para reconstituir uma composição seca, composição seca, uso de uma composição seca, e, kit
RU2715235C2 (ru) 2014-10-13 2020-02-26 Ферросан Медикал Дивайсиз А/С Сухая композиция для использования при гемостазе и заживлении ран
CA2970710A1 (en) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CN107771093B (zh) 2015-07-03 2021-06-15 弗罗桑医疗设备公司 用于混合两种组分和用于在存储条件下保持真空的注射器
US11583610B2 (en) 2017-12-29 2023-02-21 Baxter International Inc. Spray-dried thrombin and methods of using and making spray-dried thrombin
CN112368028A (zh) 2018-05-09 2021-02-12 弗罗桑医疗设备公司 用于制备止血组合物的方法
IL263679A (he) * 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd ערכות, שיטות, ותרכיבים למניעת הידבקות ברקמות
CN116392394B (zh) * 2023-05-18 2025-09-26 合肥芯能相变新材料科技有限公司 一种益生菌微胶囊制备装置及其制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
DE69418334T2 (de) 1993-08-06 2000-01-27 Opperbas Holding B.V., Amsterdam Verfahren zur hohen beladung von vesikeln mit biopolymeren substanzen
WO1997044015A1 (en) * 1996-05-17 1997-11-27 Andaris Limited Microparticles and their use in wound therapy
US6121232A (en) 1997-01-31 2000-09-19 Omrix Biopharmaceuticals Sa Stabilized mixture comprising fibrinogen
EP0856317A1 (en) 1997-01-31 1998-08-05 Omrix Biopharmaceuticals S.A. A stabilized mixture comprising fibrinogen
GB9727102D0 (en) 1997-12-22 1998-02-25 Andaris Ltd Microparticles and their therapeutic use
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
ATE342353T1 (de) 2001-05-21 2006-11-15 Omrix Biopharm Sa Abtrennung von plasmin(ogen) aus proteinlösungen
JP5037603B2 (ja) 2006-04-10 2012-10-03 エシコン・インコーポレイテッド 強化された吸収性で多層の止血用創傷手当て用品および製造方法
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
AU2009236960A1 (en) * 2008-04-16 2009-10-22 The Chemo-Sero-Therapeutic Research Institute Method of producing thrombin-immobilized bioabsorbable sheet preparation
US9827205B2 (en) * 2008-12-12 2017-11-28 Mallinckrodt Pharma Ip Trading D.A.C. Dry powder fibrin sealant
CN102724968A (zh) 2010-01-08 2012-10-10 普罗菲布瑞克斯公司 干粉血纤蛋白密封剂
MX345479B (es) * 2010-06-01 2017-02-01 Baxter Int Inc * Proceso para elaborar composiciones hemostaticas secas y estables.
BR112012030455B1 (pt) * 2010-06-01 2021-08-17 Baxter Healthcare S.A. Processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, e, kit para administrar uma composição hemostática
US9212357B2 (en) * 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
CN105188740A (zh) 2013-03-07 2015-12-23 普罗菲布里克有限公司 包含凝血酶和纤维蛋白原的粉末制剂
IL229645A0 (he) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd תחבושת יבשה המכילה תרומבין ופקטין

Also Published As

Publication number Publication date
CA3007900A1 (en) 2017-06-15
IL259185B (he) 2021-07-29
AU2016367536A1 (en) 2018-05-17
CN108366967B (zh) 2021-03-12
JP2019501893A (ja) 2019-01-24
BR112018011504A2 (pt) 2018-12-04
WO2017098493A1 (en) 2017-06-15
KR20180091035A (ko) 2018-08-14
AU2016367536B2 (en) 2021-12-02
CN108366967A (zh) 2018-08-03
IL259185A (he) 2018-07-31
JP6918799B2 (ja) 2021-08-11
EP3386487A1 (en) 2018-10-17

Similar Documents

Publication Publication Date Title
ZA201708561B (en) Microcapsules
PH12022550299A1 (en) Novel lactobacillus having various functions, and use thereof
GB201512203D0 (en) Agents,uses and methods
EP3206781A4 (en) High strength microcapsules
IL242984A0 (he) מיקרוקפסולות של תרומבין, הכנתן ואופן שימושן
IL297057B2 (he) צירופים ושימושים בהם
IL290114A (he) תכשירים רוקחיים, הכנה ושימושים בהם
GB201512215D0 (en) Agents,uses and methods
GB201408673D0 (en) Medicaments,uses and methods
HUE056175T2 (hu) Gyógyászati készítmények, elõállításuk és alkalmazásaik
IL252397A0 (he) תכשירים רוקחיים, הכנה ושימושים בהם
EP3414313A4 (en) MICRO CAPSULE
PT3229843T (pt) Composição farmacêutica, a sua preparação e as suas utilizações
IL254241A0 (he) Etv2 ושימושים בו
PT3288575T (pt) Complexo de proteína-melanina bioassimilável, sua preparação e utilizações
PL3386988T3 (pl) Nowe pochodne dihydropiranopirymidynonu i ich zastosowanie
IL249073B (he) קומפלקס ציטין–גלוקאן, הכנתו ושימושים בו
PL3122184T3 (pl) Mikrokapsułki chlomazonu, ich wytwarzanie i zastosowanie
HK1262546A1 (en) Thrombin microcapsules
GB201518375D0 (en) Agents,uses and methods
GB201512211D0 (en) Agents, uses and methods
GB201518198D0 (en) Lanthanum and uses thereof
HUP1500514A2 (en) New ppv1 strain and uses thereof
GB201502489D0 (en) Cells, preparation, uses, methods and components
AU2015900732A0 (en) Garments and Utilisation