US2465357A - Therapeutic sponge and method of making - Google Patents

Therapeutic sponge and method of making Download PDF

Info

Publication number
US2465357A
US2465357A US549483A US54948344A US2465357A US 2465357 A US2465357 A US 2465357A US 549483 A US549483 A US 549483A US 54948344 A US54948344 A US 54948344A US 2465357 A US2465357 A US 2465357A
Authority
US
United States
Prior art keywords
sponge
foam
centigrade
gelatin
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US549483A
Inventor
John T Correll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to US549483A priority Critical patent/US2465357A/en
Application granted granted Critical
Publication of US2465357A publication Critical patent/US2465357A/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0036Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/104Gelatin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
    • C08J9/00Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/30Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by mixing gases into liquid compositions or plastisols, e.g. frothing with air
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/04Materials for stopping bleeding
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
    • C08J2389/00Characterised by the use of proteins; Derivatives thereof

Description

Patented Mar. 29, 1949 NT orriclz THERAPEUTIC SPONGE AND METHOD OF MAKING John T. Correll, Kalamazoo, Mich, assignor to- The Upjohn Company company of Michigan Kalamazoo, Mich., a

No Drawing. Application August 14, 1944,

Serial No. 549,483

6 Claims.

This invention relates to a liquid-permeable, water-insoluble, gelatin sponge having the general physical characteristics of a sponge but being absorbable by animal bodies.

In various aspects of the practice of medicine and surgery it is desirable to insert into various This portions of the body a porous substance. may carry a therapeutic agent and hold such therapeutic agent in contact with certain tissues or organs. This porous substance should be reasonably soft when wet, have many fine interstices in order to hold a quantity of the therapeutic agent and to discharge it slowly, and/or act as an efiicient absorbative agent for free flowing fluids in a wound area such as blood. and exudates. It is preferably assimilable by the body in order that the incision into which it is placed need not be kept open. It is also desirable to have such a porous and assimilable substance for use as a surgical sponge in order that absorbativc packs may be left, if desired, in situ when closing an operative area, or to remove the danger present when a nonabsorbable sponge is inadvertently left in an incision. It is necessary that this substance be insoluble in water in order that it may be freely soaked in aqueous therapeutic solutions or will absorb blood and other body exudates without being affected thereby and without undue dissolution. It is further desirable that such sponge have physical properties that permit it to be readily cut into pieces which conform in size and shape to the contour of the area being treated.

Accordingly, the principal object of this inventionis to provide a sponge-like substance which has large numbers of small interstices that may be cut into convenient swabs or packs and is substantially insoluble in water, but which will be readily absorbable by the human body.

It is a further object of this invention to provide a sponge-like substance of the type mentioned which can be-manufactured in an economical manner.

It is a further object of this invention to provides. sponge-like substance of the type mentioned which can be manufacturedin aneconomical manner and which will be sterile upon arriving at the end ofitsmanufacturing process and willnot. require additional processing to insure a. sterile condition.

'Among the various problems arising in the field of medicine and surgery, there is particularly the case of minimizing the presence of blood around a surgical incision. The flow of blood is commonly stopped, or slowed by the application of a coagulating agent, such as thrombin. However, when the coagulating agentis merely poured into the incision, it impedes surgical D- erations nearly as much as" the} blood itself, or, if clotting is produced, the resulting clot quickly washes away. To prevent this, it is commonly applied by soaking small sponges in the coagulating'agent and placing them strategically within the incision.

This is effective but it presents the problem that, upon closin the wound, these 'nonabsorbable sponges must be removed, which usually results in reinstating hemorrhage. There is also the constant danger of inadvertently leaving a sponge within the incision.

It is desired, therefore, to eliminate these hazards by providing a sponge. which will be equally effective in the useas described and which will cause no inconvenience or danger if it is not removed from theincision. Also, it is frequently undesirable to remove a sponge because of the danger of starting hemorrhage. Sometimes these new sponges will be deliberately left within an incision in order to keep a constant supply of therapeutic agent at a selected point therein, as well as to preclude hemorrhage due to removal. It might also be desirable to have such a sponge whose rate of absorption into the body will be controllable so that the surgeon can select one which will remain in place the length of time which he desires. The process hereinafter disclosed by which my sponges are made can be easily controlled to vary the absorbability of the sponges as desired within considerable limits but without otherwise substantially-changing their properties.

In practicing my invention I first prepare an aqueous solution containing. 3-10% by weight of gelatin, preferably a skin gelatin, although other types, such as bone gelatin, may be employed, and these need not be highly purified. This is prepared at a relatively warm temperature, such as centigrade, allowed to cool .to-35?-40centigrade. Then I add a smallamount of formalin (40% aqueous. solution of formaldehyde), between 10.0 and 0.01 per cent based on the gelatin in solution, and incubate the resulting solution at slightly above room temperature} ('30-37 centigrade) for approximately two hours. The material is then beaten vigorously, for about. 5-15 minutes to produce a firm foam of from' i to 8 times the volume of the original solution. This is placed on a monel wire screen in a drying oven and large quantities of air at about 30 to 33 centigrade and 10% humidity are circulated through it. i This is continued until the foam is dry. When thoroughly dry, the foam is heated to a temperature of .approximately 140 centigrade, and allowed to remain there for about water at 80 centigrade, and cooled the resulting solution to 35 centigrade. Then I added 0.03 cubic centimeter of 40 per cent formalin and incubated the resulting mixture at 37 centigrade for about 2 hours, The solution was beaten vigorously for about minutes, at which time it had formed a firm foam with a volume of about 600 cubic centimeters. The foam was then placed on screens in a drying oven at 33 centigrade and large quantities of substantially dry air relative humidity) circulated through said oven at the same temperature. This was continued until the foam was thoroughly dry, whereupon it was heated to 140"-145 centigrade and kept at such temperature for three hours. quantities above mentioned, produced about 500 cubic centimeters of a dry, sterile, liquid-permeable, water insoluble gelatin sponge which was firm when dry but softened without dissolving when saturated with water. The dry material was suiliciently firm to be out easily by a small knife into whatever shapes and sizes were desired. The final heat treatment may be interrupted for packaging purposes, if desired, without disadvantage.

In practicing my invention, certain variations will be found at times convenient. In dissolvin the gelatin, any temperature of water will be usable provided only it is somewhat below the boiling point and hot enough to dissolve the gelatin with reasonable rapidity, The gelatin may be swelled with cold water before dissolving, if desired. The temperature to which it is cooled should be in the general region of 35 to 40 centigrade. The amount of formalin added will control the hardness of the sponge and its rate of absorption into the body. The more formalin the harder will be the sponge and the more slowly it will absorb. Also, the higher the temperature employed up to a scorching range, or the longer the heating-period employed in the final step of processing the-sponge, correspondingly influence -the,physical properties of the sponge and its rate of physiologic absorption. Optimal ranges for these influencing factors appear to be 0.03 to 0.3 cubic centimeter of formalin per 5 grams of gelatin and 100 grams of water, and heating of the dry sponge at 130 to 150 centigrade for from 2 to .5 hours, In beating the mixture, any time is to be used which is required to secure the foam but this will ordinarily be somewhat less than minutes. In drying the foam, any temperature which will not melt the foam at the particular humidity of the air employed will be acceptable, but I have found that temperatures above centigrade tend to melt the foam and lower temperatures require too much time for drying without providing any noticeable advantage. The relative humidity of the air should not exceed about 15 per cent. The step of heating the dried foam to 140-l45 centigrade increases the water insolubility and this temperature appears to be quite critical. An appreciably higher temperature will scorch the sponge and a temperature much below 130 centigrade will not yield a prod- This, for the uot with satisfactory physical properties. The use of formaldehyde or other hardening agent may be dispensed with and the foam hardened and insolubilized by the heating step alone. This step also makes the sponge sterile.

It is not known exactly how the sponge prepared by the above described method is absorbed by the body, but it is an observed fact that it is so absorbed in from ten to ninety days, depending upon the above-suggested variations in man ner of making the sponge, and no trace remains. The sponge is digested in vitro by enzymatic action, as by pepsin trypsin, and other proteolytic enzymes.

Having fully described my invention, I claim:

1. In the preparation of a gelatin sponge, the process: Preparing a 5 per cent by weight aqueous solution of gelatin at a temperature above room temperature but substantially below boiling, cooling same to approximately 35 centigrade, adding an amount of formalin between 0.01 and 10.0 cubic centimeters thereof per cubic centimeters of gelatin in solution, incubating the same at approximately 37 centigrade for about 2 hours, whipping the same until a foam is formed, drying the foam-at 33 centigrade and 10 per cent humidity, heating the dry foam for approximately three hours at a temperature of approximately 140 centigrade.

2. In the preparation of a gelatin foam, the process: preparing an aqueous solution of gelatin and bringing same to room temperature, adding formaldehyde thereto in an amount between 0.03 and 0.1 grams of 40% aqueous solution thereof per 5 grams of gelatin, whipping same until foam is formed, passing dry air at a temperature below about 35 centigrade through the foam to remove substantially all water therefrom, and heating the dry foam for approximately three hours at a temperature between and centigrade.

3. In the preparation of a gelatin foam, the process: mixing a limited amount of formaldehyde into an aqueous gelatin solution, beating said mixture until a foam is formed, removing substantially all of the water from said foam at a temperature below about 35 centigrade, and heating said dry foam for a substantial period of time at a temperature of at least about 130' and not substantially exceeding-about centirade.

4. In the preparation of a gelatin foam, the steps which include: forming an aqueous gelatin solution, beating said solution until a foam is formed, removing at a temperature below about 35 centigrade substantially all of the water from said foam. and heating said dry foam for a substantial period of time at a temperature above about 130 centigrade but not sufficiently elevated to cause scorching of the foam.

5. In the preparation of a gelatin sponge, the

- process which includes: preparing a 5 per cent by weight aqueous solution of gelatin at a temperature above room temperature but substantially below boiling, cooling same to approximately 35 centigrade, adding an amount of formalin between 0.01 and 1.0 cubic centimeter thereof per 100 cubic centimeters of gelatin solution, incubating the same at approximately 37 centigrade for about two hours, whipping the same until a foam is formed, drying the foam at a temperature below about 35 centigrade at about 10 per cent humidity, and heating the dry foam for approximately three hours at a temperature be- /tween about 130 and about 145 centigrade.

6. A water-permeable surgical sponge having a matrix consisting essentially of gelatin sponge UNITED STATES PATENTS hardened to the point of water insolubility and 5223 gffi a1 g characterized by substantially complete biological 1 985994 Holcomb 1935 absorbability in a living animal body in between 5 1999641 sharp 1935 abut ten and ninety days' 2 036 913 Brown $11111- Aor. '1 1936 JOHN T. CORRELL 2,141,760 Mould Dec. 27, 1938 FOREIGN PATENTS REFERENCES CITED 10 Number Country Date The following references are of record in the 265,968 Great Britain 1927 file of this patent: 674,775 Germany 1939

US549483A 1944-08-14 1944-08-14 Therapeutic sponge and method of making Expired - Lifetime US2465357A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US549483A US2465357A (en) 1944-08-14 1944-08-14 Therapeutic sponge and method of making

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US549483A US2465357A (en) 1944-08-14 1944-08-14 Therapeutic sponge and method of making

Publications (1)

Publication Number Publication Date
US2465357A true US2465357A (en) 1949-03-29

Family

ID=24193202

Family Applications (1)

Application Number Title Priority Date Filing Date
US549483A Expired - Lifetime US2465357A (en) 1944-08-14 1944-08-14 Therapeutic sponge and method of making

Country Status (1)

Country Link
US (1) US2465357A (en)

Cited By (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2591927A (en) * 1948-10-06 1952-04-08 Sidney A Gladstone Obtaining tumor tissue specimen
US2712672A (en) * 1952-01-28 1955-07-12 Calcagno Luigi Process for preparing proteic sponges
US2731015A (en) * 1953-03-16 1956-01-17 Ohio Commw Eng Co Artificial sponge and method of making it
DE950751C (en) * 1952-02-01 1956-10-18 Behringwerke Ag A process for the preparation spontaneously and rapidly absorbent tampons of absorbable material
US2854978A (en) * 1956-07-24 1958-10-07 Ortho Pharma Corp Applicator
US2899362A (en) * 1959-08-11 Hemostatic sponges and method of
DE1105112B (en) * 1954-08-10 1961-04-20 Dr Luigi Calcagno A process for preparing Gelatineschwaemmen
US3121041A (en) * 1960-07-20 1964-02-11 Olin Mathieson Capsule containing a pharmaceutically useful radioactive material
US3127313A (en) * 1964-03-31 Method of making a radioactive
US3234091A (en) * 1955-07-08 1966-02-08 Ciba Geigy Corp Shaped medicaments and process for their manufacture
US3266054A (en) * 1963-07-05 1966-08-09 Jimenez Marcos Method for treatment of hernias
US3300470A (en) * 1963-10-04 1967-01-24 Swift & Co Reaction products of protein with cyanamide under acidic conditions
US3451394A (en) * 1961-04-04 1969-06-24 Ethicon Inc Radiating tanned and untanned collagen prosthesis with 5 to 25 megarads of ionizing radiation
US3516834A (en) * 1966-03-18 1970-06-23 Eastman Kodak Co Ionizing radiation sensitive photographic element comprising foamed gelatin-silver halide emulsion
US3799166A (en) * 1972-05-22 1974-03-26 A Marsan Starch type gel seals for ostomy patients
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
US4265233A (en) * 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
US4292972A (en) * 1980-07-09 1981-10-06 E. R. Squibb & Sons, Inc. Lyophilized hydrocolloio foam
US4341207A (en) * 1979-09-07 1982-07-27 Kingsdown Medical Consultants Limited Wound dressing
US4372314A (en) * 1980-09-15 1983-02-08 Wall W Henry Dental sponge
US4538603A (en) * 1982-04-22 1985-09-03 E. R. Squibb & Sons, Inc. Dressings, granules, and their use in treating wounds
US4708869A (en) * 1969-09-02 1987-11-24 The United States Of America As Represented By The Secretary Of The Army Persistent incapacitating chemical warfare composition and its use
US5039414A (en) * 1989-08-01 1991-08-13 Mueller Marc B Process for separating and/or recovering hydrocarbon oils from water using biodegradable absorbent sponges
US5795584A (en) * 1993-01-27 1998-08-18 United States Surgical Corporation Post-surgical anti-adhesion device
US5904717A (en) * 1986-01-28 1999-05-18 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US5935594A (en) * 1993-10-28 1999-08-10 Thm Biomedical, Inc. Process and device for treating and healing a tissue deficiency
US5981825A (en) * 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US6071301A (en) * 1998-05-01 2000-06-06 Sub Q., Inc. Device and method for facilitating hemostasis of a biopsy tract
US6162192A (en) * 1998-05-01 2000-12-19 Sub Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
WO2000078228A1 (en) * 1999-06-17 2000-12-28 Sub-Q, Inc. Absorbable sponge with contrasting agent
US6200328B1 (en) 1998-05-01 2001-03-13 Sub Q, Incorporated Device and method for facilitating hemostasis of a biopsy tract
US6315753B1 (en) 1998-05-01 2001-11-13 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6399380B1 (en) 1991-02-28 2002-06-04 Anti-Cancer, Inc. Native-state histoculturing skin extracellular support
WO2002072128A1 (en) * 2001-03-12 2002-09-19 Sub-Q, Inc. Cross-linked gelatin composition comprising a wetting agent
US20020156495A1 (en) * 1995-09-15 2002-10-24 Rodney Brenneman Apparatus and method for percutaneous sealing of blood vessel punctures
US20020187104A1 (en) * 2001-06-08 2002-12-12 Wyeth Calcuim phosphate delivery vehicles for osteoinductive proteins
US20020190226A1 (en) * 2001-03-12 2002-12-19 Mark Ashby Methods for sterilizing cross-linked gelatin compositions
US20030049826A1 (en) * 1986-07-01 2003-03-13 Genetics Institute, Inc. Novel BMP products
US6540735B1 (en) 2000-05-12 2003-04-01 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6544236B1 (en) 1999-02-10 2003-04-08 Sub-Q, Incorporated Device, system and method for improving delivery of hemostatic material
US6610026B2 (en) 1998-05-01 2003-08-26 Sub-Q, Inc. Method of hydrating a sponge material for delivery to a body
US20030162708A1 (en) * 2001-12-21 2003-08-28 Jorgen Wolff Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US20030170208A1 (en) * 2001-06-01 2003-09-11 Brian Clancy Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
US20040019330A1 (en) * 2001-11-08 2004-01-29 Sub-Q, Inc., A California Corporation Sheath based blood vessel puncture locator and depth indicator
US20040102730A1 (en) * 2002-10-22 2004-05-27 Davis Thomas P. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
WO2004053051A2 (en) * 2002-12-11 2004-06-24 Ferrosan A/S Gelatine-based materials as swabs
US20040138601A1 (en) * 2001-05-16 2004-07-15 Chalmers Susanna Elizabeth Wound dressings and wound treatment compositions
US20040142417A1 (en) * 1993-09-17 2004-07-22 Genetics Institute, Llc. Receptor proteins
US20040158287A1 (en) * 2000-07-14 2004-08-12 Cragg Andrew H. Sheath-mounted arterial plug delivery device
US20040176723A1 (en) * 2001-11-08 2004-09-09 Sing Eduardo Chi Pledget-handling system and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US20040192605A1 (en) * 1999-02-01 2004-09-30 Genetics Institute, Llc Methods and compositions for healing and repair of articular cartilage
US6846320B2 (en) 1998-05-01 2005-01-25 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US20050033360A1 (en) * 2001-11-08 2005-02-10 Sing Eduardo Chi Pledget-handling system and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US6863680B2 (en) 2001-11-08 2005-03-08 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US20050089579A1 (en) * 2003-09-12 2005-04-28 Rebecca Li Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
US20050175659A1 (en) * 2004-02-09 2005-08-11 Macomber Laurel R. Collagen device and method of preparing the same
US20050283256A1 (en) * 2004-02-09 2005-12-22 Codman & Shurtleff, Inc. Collagen device and method of preparing the same
US6984219B2 (en) 1999-09-23 2006-01-10 Mark Ashby Depth and puncture control for blood vessel hemostasis system
US6984623B2 (en) 1993-12-07 2006-01-10 Genetics, Institute Institute, LLC. Tendon-inducing compositions
US7008440B2 (en) 2001-11-08 2006-03-07 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US7029489B1 (en) 2001-05-18 2006-04-18 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture site
US7037322B1 (en) 2001-11-08 2006-05-02 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture with a staging tube
US20060252724A1 (en) * 2000-12-01 2006-11-09 Wyeth Method and composition for modulating bone growth
US20070009578A1 (en) * 2004-07-09 2007-01-11 Lene Moller Haemostatic composition comprising hyaluronic acid
US7189392B1 (en) 1999-10-15 2007-03-13 Genetics Institute, Llc Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
US20070073415A1 (en) * 2005-09-29 2007-03-29 Codman And Shurtleff, Inc. Dural graft and method of preparing the same
US7201725B1 (en) 2000-09-25 2007-04-10 Sub-Q, Inc. Device and method for determining a depth of an incision
US20070160543A1 (en) * 2004-01-30 2007-07-12 Lene Moller Haemostatic sprays and compositions
US7335219B1 (en) 2002-11-04 2008-02-26 Sub-Q, Inc. Hemostatic device including a capsule
US20080076722A1 (en) * 2006-09-27 2008-03-27 Hemostasis, Llc Hemostatic Agent and Method
US20080082084A1 (en) * 2006-09-29 2008-04-03 Hemostasis, Llc System and Method to Vent Gas From a Body Cavity
US20080139474A1 (en) * 1991-11-04 2008-06-12 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US20090035356A1 (en) * 2005-09-06 2009-02-05 Trung Bui-Khac Modified biodegradable polymers, preparation and use thereof for making biomaterials and dressings
US20090105137A1 (en) * 1991-11-04 2009-04-23 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US20090226391A1 (en) * 2008-03-04 2009-09-10 Hemostasis, Llc Hemostatic Sponge and Method of Manufacture
US20090269413A1 (en) * 2008-04-23 2009-10-29 Codman & Shurtleff, Inc. Flowable collagen material for dural closure
US7625352B1 (en) 1998-05-01 2009-12-01 Sub-Q, Inc. Depth and puncture control for system for hemostasis of blood vessel
US7695492B1 (en) 1999-09-23 2010-04-13 Boston Scientific Scimed, Inc. Enhanced bleed back system
US20100183582A1 (en) * 2003-08-07 2010-07-22 Ethicon, Inc. Hemostatic compositions containing sterile thrombin
US20110014290A1 (en) * 1995-09-15 2011-01-20 Boston Scientific Scimed, Inc. System and method for facilitating hemostasis with an absorbable sponge
US7875043B1 (en) 2003-12-09 2011-01-25 Sub-Q, Inc. Cinching loop
US20110021964A1 (en) * 2008-02-29 2011-01-27 Ferrosan Medical Devices A/S Device for Promotion of Hemostasis and/or Wound Healing
US20110052663A1 (en) * 2009-09-01 2011-03-03 Hemostasis, Llc Hemostatic Sponge with Enzyme and Method of Manufacture
US7955353B1 (en) 2002-11-04 2011-06-07 Sub-Q, Inc. Dissolvable closure device
WO2011144916A1 (en) 2010-05-20 2011-11-24 Fujifilm Manufacturing Europe Bv Hemostatic compositions
US8317821B1 (en) 2002-11-04 2012-11-27 Boston Scientific Scimed, Inc. Release mechanism
US8585646B2 (en) 2008-03-03 2013-11-19 Lexion Medical, Llc System and method to vent gas from a body cavity
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US948845A (en) * 1909-07-06 1910-02-08 Robert John Caldwell Manufacture of filling or stuffing material.
GB265968A (en) * 1926-02-09 1927-12-22 Erik Christian Bayer Method of producing porous materials and porous insulating materials produced by the said method
US1985994A (en) * 1932-01-13 1935-01-01 Johns Manville Porous material and process of making the same
US1999641A (en) * 1932-07-30 1935-04-30 Davis & Sharp Strand for suture and other purposes and method of making the same
US2036913A (en) * 1932-08-06 1936-04-07 Johns Manville Sound absorbing article
US2141760A (en) * 1938-08-01 1938-12-27 Tryit Novelty Company Imitation drink
DE674775C (en) * 1934-10-20 1939-04-21 Erik Christian Bayer A process for producing heat and sound insulating of a solution of animal glue

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US948845A (en) * 1909-07-06 1910-02-08 Robert John Caldwell Manufacture of filling or stuffing material.
GB265968A (en) * 1926-02-09 1927-12-22 Erik Christian Bayer Method of producing porous materials and porous insulating materials produced by the said method
US1985994A (en) * 1932-01-13 1935-01-01 Johns Manville Porous material and process of making the same
US1999641A (en) * 1932-07-30 1935-04-30 Davis & Sharp Strand for suture and other purposes and method of making the same
US2036913A (en) * 1932-08-06 1936-04-07 Johns Manville Sound absorbing article
DE674775C (en) * 1934-10-20 1939-04-21 Erik Christian Bayer A process for producing heat and sound insulating of a solution of animal glue
US2141760A (en) * 1938-08-01 1938-12-27 Tryit Novelty Company Imitation drink

Cited By (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3127313A (en) * 1964-03-31 Method of making a radioactive
US2899362A (en) * 1959-08-11 Hemostatic sponges and method of
US2591927A (en) * 1948-10-06 1952-04-08 Sidney A Gladstone Obtaining tumor tissue specimen
US2712672A (en) * 1952-01-28 1955-07-12 Calcagno Luigi Process for preparing proteic sponges
DE950751C (en) * 1952-02-01 1956-10-18 Behringwerke Ag A process for the preparation spontaneously and rapidly absorbent tampons of absorbable material
US2731015A (en) * 1953-03-16 1956-01-17 Ohio Commw Eng Co Artificial sponge and method of making it
DE1105112B (en) * 1954-08-10 1961-04-20 Dr Luigi Calcagno A process for preparing Gelatineschwaemmen
US3234091A (en) * 1955-07-08 1966-02-08 Ciba Geigy Corp Shaped medicaments and process for their manufacture
US2854978A (en) * 1956-07-24 1958-10-07 Ortho Pharma Corp Applicator
US3121041A (en) * 1960-07-20 1964-02-11 Olin Mathieson Capsule containing a pharmaceutically useful radioactive material
US3451394A (en) * 1961-04-04 1969-06-24 Ethicon Inc Radiating tanned and untanned collagen prosthesis with 5 to 25 megarads of ionizing radiation
US3266054A (en) * 1963-07-05 1966-08-09 Jimenez Marcos Method for treatment of hernias
US3300470A (en) * 1963-10-04 1967-01-24 Swift & Co Reaction products of protein with cyanamide under acidic conditions
US3516834A (en) * 1966-03-18 1970-06-23 Eastman Kodak Co Ionizing radiation sensitive photographic element comprising foamed gelatin-silver halide emulsion
US4708869A (en) * 1969-09-02 1987-11-24 The United States Of America As Represented By The Secretary Of The Army Persistent incapacitating chemical warfare composition and its use
US3799166A (en) * 1972-05-22 1974-03-26 A Marsan Starch type gel seals for ostomy patients
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
US4265233A (en) * 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
US4341207A (en) * 1979-09-07 1982-07-27 Kingsdown Medical Consultants Limited Wound dressing
US4292972A (en) * 1980-07-09 1981-10-06 E. R. Squibb & Sons, Inc. Lyophilized hydrocolloio foam
EP0044624A1 (en) * 1980-07-09 1982-01-27 E.R. Squibb & Sons, Inc. Lyophilized hydrocolloid foam
US4372314A (en) * 1980-09-15 1983-02-08 Wall W Henry Dental sponge
US4538603A (en) * 1982-04-22 1985-09-03 E. R. Squibb & Sons, Inc. Dressings, granules, and their use in treating wounds
US5904717A (en) * 1986-01-28 1999-05-18 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US20050159348A9 (en) * 1986-07-01 2005-07-21 Elizabeth Wang Methods of treatment of periodontal disease
US20040009916A1 (en) * 1986-07-01 2004-01-15 Elizabeth Wang Methods of treatment of periodontal disease
US7217691B2 (en) 1986-07-01 2007-05-15 Genetics Institute, Llc Methods of treatment of periodontal disease
US7300772B2 (en) 1986-07-01 2007-11-27 Genetics Institute, Llc BMP products
US20030049826A1 (en) * 1986-07-01 2003-03-13 Genetics Institute, Inc. Novel BMP products
US5039414A (en) * 1989-08-01 1991-08-13 Mueller Marc B Process for separating and/or recovering hydrocarbon oils from water using biodegradable absorbent sponges
US6399380B1 (en) 1991-02-28 2002-06-04 Anti-Cancer, Inc. Native-state histoculturing skin extracellular support
US7678885B2 (en) 1991-11-04 2010-03-16 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US20080139474A1 (en) * 1991-11-04 2008-06-12 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US20090105137A1 (en) * 1991-11-04 2009-04-23 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US5795584A (en) * 1993-01-27 1998-08-18 United States Surgical Corporation Post-surgical anti-adhesion device
US20040142417A1 (en) * 1993-09-17 2004-07-22 Genetics Institute, Llc. Receptor proteins
US7091007B2 (en) 1993-09-17 2006-08-15 Genetics Institute, Llc DNA molecules encoding BMP receptor proteins
US5935594A (en) * 1993-10-28 1999-08-10 Thm Biomedical, Inc. Process and device for treating and healing a tissue deficiency
US20070004005A1 (en) * 1993-12-07 2007-01-04 Genetics Institute, Llc Tendon-inducing compositions
US7365052B2 (en) 1993-12-07 2008-04-29 Genetics Institute, Llc. Tendon-inducing methods
US6984623B2 (en) 1993-12-07 2006-01-10 Genetics, Institute Institute, LLC. Tendon-inducing compositions
US6264701B1 (en) 1994-05-13 2001-07-24 Kensey Nash Corporation Device and methods for in vivo culturing of diverse tissue cells
US5981825A (en) * 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US20020156495A1 (en) * 1995-09-15 2002-10-24 Rodney Brenneman Apparatus and method for percutaneous sealing of blood vessel punctures
US7175646B2 (en) 1995-09-15 2007-02-13 Boston Scientific Scimed, Inc. Apparatus and method for percutaneous sealing of blood vessel punctures
US20110014290A1 (en) * 1995-09-15 2011-01-20 Boston Scientific Scimed, Inc. System and method for facilitating hemostasis with an absorbable sponge
US6447534B2 (en) 1998-05-01 2002-09-10 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US20030088271A1 (en) * 1998-05-01 2003-05-08 Cragg Andrew M. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US20030135237A1 (en) * 1998-05-01 2003-07-17 Cragg Andrew H. Device, system and method for improving delivery of hemostatic material
US6610026B2 (en) 1998-05-01 2003-08-26 Sub-Q, Inc. Method of hydrating a sponge material for delivery to a body
US6200328B1 (en) 1998-05-01 2001-03-13 Sub Q, Incorporated Device and method for facilitating hemostasis of a biopsy tract
US7753872B2 (en) 1998-05-01 2010-07-13 Boston Scientific Scimed, Inc. Device, system and method for improving delivery of hemostatic material
US6183497B1 (en) 1998-05-01 2001-02-06 Sub-Q, Inc. Absorbable sponge with contrasting agent
US7618567B2 (en) 1998-05-01 2009-11-17 Boston Scientific Scimed, Inc. Absorbable sponge with contrasting agent
US6162192A (en) * 1998-05-01 2000-12-19 Sub Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6071301A (en) * 1998-05-01 2000-06-06 Sub Q., Inc. Device and method for facilitating hemostasis of a biopsy tract
US7048710B1 (en) 1998-05-01 2006-05-23 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6440153B2 (en) 1998-05-01 2002-08-27 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US7625352B1 (en) 1998-05-01 2009-12-01 Sub-Q, Inc. Depth and puncture control for system for hemostasis of blood vessel
US6527734B2 (en) 1998-05-01 2003-03-04 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6315753B1 (en) 1998-05-01 2001-11-13 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6846320B2 (en) 1998-05-01 2005-01-25 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US7611479B2 (en) 1998-05-01 2009-11-03 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US8050741B2 (en) 1998-05-01 2011-11-01 Boston Scientific Scimed, Inc. Device and method for facilitating hemostasis of a biopsy tract
US20050113737A1 (en) * 1998-05-01 2005-05-26 Mark Ashby Device and method for facilitating hemostasis of a biopsy tract
US6440151B1 (en) 1998-05-01 2002-08-27 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US20050059080A1 (en) * 1998-05-01 2005-03-17 Sing Eduardo Chi Absorbable sponge with contrasting agent
US20100029908A1 (en) * 1998-05-01 2010-02-04 Boston Scientific Scimed, Inc. Absorbable sponge with contrasting agent
US20100036414A1 (en) * 1998-05-01 2010-02-11 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US20040192605A1 (en) * 1999-02-01 2004-09-30 Genetics Institute, Llc Methods and compositions for healing and repair of articular cartilage
US7323445B2 (en) 1999-02-01 2008-01-29 Genetics Institute, Llc Methods and compositions for healing and repair of articular cartilage
US6544236B1 (en) 1999-02-10 2003-04-08 Sub-Q, Incorporated Device, system and method for improving delivery of hemostatic material
WO2000078228A1 (en) * 1999-06-17 2000-12-28 Sub-Q, Inc. Absorbable sponge with contrasting agent
US7695492B1 (en) 1999-09-23 2010-04-13 Boston Scientific Scimed, Inc. Enhanced bleed back system
US6984219B2 (en) 1999-09-23 2006-01-10 Mark Ashby Depth and puncture control for blood vessel hemostasis system
US7189392B1 (en) 1999-10-15 2007-03-13 Genetics Institute, Llc Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
US6964658B2 (en) 2000-05-12 2005-11-15 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6540735B1 (en) 2000-05-12 2003-04-01 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US8696702B2 (en) 2000-07-14 2014-04-15 Boston Scientific Scimed, Inc. Sheath-mounted arterial plug delivery device
US20100049245A1 (en) * 2000-07-14 2010-02-25 Boston Scientific Scimed, Inc. Sheath-mounted arterial plug delivery device
US7621936B2 (en) 2000-07-14 2009-11-24 Boston Scientific Scimed, Inc. Sheath-mounted arterial plug delivery device
US20040158287A1 (en) * 2000-07-14 2004-08-12 Cragg Andrew H. Sheath-mounted arterial plug delivery device
US7201725B1 (en) 2000-09-25 2007-04-10 Sub-Q, Inc. Device and method for determining a depth of an incision
US20060252724A1 (en) * 2000-12-01 2006-11-09 Wyeth Method and composition for modulating bone growth
US7264772B2 (en) 2001-03-12 2007-09-04 Boston Scientific Scimed, Inc. Methods for sterilizing cross-linked gelatin compositions
WO2002072128A1 (en) * 2001-03-12 2002-09-19 Sub-Q, Inc. Cross-linked gelatin composition comprising a wetting agent
US8187625B2 (en) 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
US20020190226A1 (en) * 2001-03-12 2002-12-19 Mark Ashby Methods for sterilizing cross-linked gelatin compositions
US6849232B2 (en) 2001-03-12 2005-02-01 Sub-Q, Inc. Methods for sterilizing cross-linked gelatin compositions
US8524270B2 (en) 2001-03-12 2013-09-03 Boston Scientific Scimed, Inc. Cross-linked gelatin composition coated with a wetting agent
US8821918B2 (en) 2001-03-12 2014-09-02 Boston Scientific Scimed Inc. Cross-linked gelatin composition comprising a wetting agent
US20040138601A1 (en) * 2001-05-16 2004-07-15 Chalmers Susanna Elizabeth Wound dressings and wound treatment compositions
US7074981B2 (en) * 2001-05-16 2006-07-11 Susanna Elizabeth Chalmers Wound dressings and wound treatment compositions
US7029489B1 (en) 2001-05-18 2006-04-18 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture site
US7226587B2 (en) 2001-06-01 2007-06-05 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
US20030170208A1 (en) * 2001-06-01 2003-09-11 Brian Clancy Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
US20020187104A1 (en) * 2001-06-08 2002-12-12 Wyeth Calcuim phosphate delivery vehicles for osteoinductive proteins
US20100074876A1 (en) * 2001-06-08 2010-03-25 Wyeth Calcium phosphate delivery vehicles for osteoinductive proteins
US7622139B2 (en) 2001-06-08 2009-11-24 Wyeth Calcium phosphate delivery vehicles for osteoinductive proteins
US7413753B2 (en) 2001-06-08 2008-08-19 Wyeth Calcium phosphate delivery vehicles for osteoinductive proteins
US8003133B2 (en) 2001-06-08 2011-08-23 Wyeth Llc Calcium phosphate delivery vehicles for osteoinductive proteins
US20080096797A1 (en) * 2001-06-08 2008-04-24 Wyeth Calcium phosphate delivery vehicles for osteoinductive proteins
US7008440B2 (en) 2001-11-08 2006-03-07 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US20050033360A1 (en) * 2001-11-08 2005-02-10 Sing Eduardo Chi Pledget-handling system and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US7192436B2 (en) 2001-11-08 2007-03-20 Sub-Q, Inc. Pledget-handling system and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US20040176723A1 (en) * 2001-11-08 2004-09-09 Sing Eduardo Chi Pledget-handling system and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US20040019330A1 (en) * 2001-11-08 2004-01-29 Sub-Q, Inc., A California Corporation Sheath based blood vessel puncture locator and depth indicator
US7025748B2 (en) 2001-11-08 2006-04-11 Boston Scientific Scimed, Inc. Sheath based blood vessel puncture locator and depth indicator
US6863680B2 (en) 2001-11-08 2005-03-08 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US7037322B1 (en) 2001-11-08 2006-05-02 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture with a staging tube
US7037323B2 (en) 2001-11-08 2006-05-02 Sub-Q, Inc. Pledget-handling system and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US20030162708A1 (en) * 2001-12-21 2003-08-28 Jorgen Wolff Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US8283320B2 (en) 2001-12-21 2012-10-09 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostasis
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US20040102730A1 (en) * 2002-10-22 2004-05-27 Davis Thomas P. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US8317821B1 (en) 2002-11-04 2012-11-27 Boston Scientific Scimed, Inc. Release mechanism
US7955353B1 (en) 2002-11-04 2011-06-07 Sub-Q, Inc. Dissolvable closure device
US7335219B1 (en) 2002-11-04 2008-02-26 Sub-Q, Inc. Hemostatic device including a capsule
WO2004053051A2 (en) * 2002-12-11 2004-06-24 Ferrosan A/S Gelatine-based materials as swabs
US7955288B2 (en) 2002-12-11 2011-06-07 Ferrosan Medical Devices A/S Gelatine-based materials as swabs
US20060115805A1 (en) * 2002-12-11 2006-06-01 Hansen John E Gelatine-based materials as swabs
WO2004053051A3 (en) * 2002-12-11 2005-03-10 Ferrosan As Gelatine-based materials as swabs
US20100183582A1 (en) * 2003-08-07 2010-07-22 Ethicon, Inc. Hemostatic compositions containing sterile thrombin
US9005609B2 (en) 2003-08-07 2015-04-14 Ethicon, Inc. Hemostatic compositions containing sterile thrombin
US8507008B2 (en) 2003-09-12 2013-08-13 Etex Corporation Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
US7771755B2 (en) 2003-09-12 2010-08-10 Wyeth Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
US20100273706A1 (en) * 2003-09-12 2010-10-28 Wyeth and ETEX Corp. Injectable Calcium Phosphate Solid Rods and Pastes for Delivery of Osteogenic Proteins
US20050089579A1 (en) * 2003-09-12 2005-04-28 Rebecca Li Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
US7875043B1 (en) 2003-12-09 2011-01-25 Sub-Q, Inc. Cinching loop
US20070160543A1 (en) * 2004-01-30 2007-07-12 Lene Moller Haemostatic sprays and compositions
US7923031B2 (en) 2004-01-30 2011-04-12 Ferrosan Medical Devices A/S Haemostatic sprays and compositions
US20050175659A1 (en) * 2004-02-09 2005-08-11 Macomber Laurel R. Collagen device and method of preparing the same
US20090030526A1 (en) * 2004-02-09 2009-01-29 Codman & Shurtleff, Inc. Collagen device and method of preparing the same
US20050283256A1 (en) * 2004-02-09 2005-12-22 Codman & Shurtleff, Inc. Collagen device and method of preparing the same
US8795710B2 (en) 2004-02-09 2014-08-05 Codman & Shurtleff, Inc. Collagen device and method of preparing the same
US20070009578A1 (en) * 2004-07-09 2007-01-11 Lene Moller Haemostatic composition comprising hyaluronic acid
US8021684B2 (en) 2004-07-09 2011-09-20 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
US20090035356A1 (en) * 2005-09-06 2009-02-05 Trung Bui-Khac Modified biodegradable polymers, preparation and use thereof for making biomaterials and dressings
US20070073415A1 (en) * 2005-09-29 2007-03-29 Codman And Shurtleff, Inc. Dural graft and method of preparing the same
US20080208359A1 (en) * 2005-09-29 2008-08-28 Codman & Shurtleff, Inc. Dural graft and method of preparing the same
US7429241B2 (en) 2005-09-29 2008-09-30 Codman & Shurtleff, Inc. Dural graft and method of preparing the same
US20080076722A1 (en) * 2006-09-27 2008-03-27 Hemostasis, Llc Hemostatic Agent and Method
US9649482B2 (en) 2006-09-27 2017-05-16 Hemostasis, Llc Hemostatic agent and method
US8623842B2 (en) 2006-09-27 2014-01-07 Hemostasis, Llc Hemostatic agent and method
US8414550B2 (en) 2006-09-29 2013-04-09 Lexion Medical, Llc System and method to vent gas from a body cavity
US8608715B2 (en) 2006-09-29 2013-12-17 Lexion Medical, Llc System and method to vent gas from a body cavity
US20080082084A1 (en) * 2006-09-29 2008-04-03 Hemostasis, Llc System and Method to Vent Gas From a Body Cavity
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US20110021964A1 (en) * 2008-02-29 2011-01-27 Ferrosan Medical Devices A/S Device for Promotion of Hemostasis and/or Wound Healing
US8642831B2 (en) 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9821095B2 (en) 2008-03-03 2017-11-21 Lexion Medical, Llc System and method to vent gas from a body cavity
US8585646B2 (en) 2008-03-03 2013-11-19 Lexion Medical, Llc System and method to vent gas from a body cavity
US9061087B2 (en) 2008-03-04 2015-06-23 Hemostasis, Llc Method of making a hemostatic sponge wound dressing comprising subjecting the sponge to water vapor
US20090226391A1 (en) * 2008-03-04 2009-09-10 Hemostasis, Llc Hemostatic Sponge and Method of Manufacture
US20090269413A1 (en) * 2008-04-23 2009-10-29 Codman & Shurtleff, Inc. Flowable collagen material for dural closure
US8039591B2 (en) 2008-04-23 2011-10-18 Codman & Shurtleff, Inc. Flowable collagen material for dural closure
US20110052663A1 (en) * 2009-09-01 2011-03-03 Hemostasis, Llc Hemostatic Sponge with Enzyme and Method of Manufacture
WO2011144916A1 (en) 2010-05-20 2011-11-24 Fujifilm Manufacturing Europe Bv Hemostatic compositions
US9999703B2 (en) 2012-06-12 2018-06-19 Ferrosan Medical Devices A/S Dry haemostatic composition
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer

Similar Documents

Publication Publication Date Title
US3443261A (en) Prosthetic structures from microcrystalline collagen
Waltz et al. Sarcoma: A possible late result of effective radiation therapy for pituitary adenoma: Report of two cases
US3632361A (en) Water-insoluble microcrystalline collagen absorbent mat
Barvicč et al. Biologic properties and possible uses of polymer‐like sponges
US4597762A (en) Collagen preparation
DE3034273C2 (en)
US5326350A (en) Soft tissue closure systems
CA1146469A (en) Lyophilized hydrocolloid foam
US2899362A (en) Hemostatic sponges and method of
DE2657684C2 (en)
US3875937A (en) Surgical dressings of absorbable polymers
US3975567A (en) Surgical dressings
EP0030583B1 (en) Bone replacement material and process for producing a bone replacement material
US3767784A (en) Composition for the protection and treatment of injured body tissue and method of utilizing the same
KR100431659B1 (en) Wound dressing material containing silk fibroin and sericin as a main component and method for preparing same
Davidson Animal models for wound repair
Attwood Calcium alginate dressing accelerates split skin graft donor site healing
US2682873A (en) General purpose protective dressing
RU2369408C2 (en) Hemostatic composition comprising hyaluronic acid
AU2009239783B2 (en) Haemostatic material
JP2719671B2 (en) Wound dressing
Brandenberg et al. Chitosan: a new topical hemostatic agent for diffuse capillary bleeding in brain tissue
US3978266A (en) Surgical dressings
US3736646A (en) Method of attaching surgical needles to multifilament polyglycolic acid absorbable sutures
US4749689A (en) Hemostatic agent composed of collagen/gelatin and protamine