IT1282219B1 - Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa - Google Patents

Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Info

Publication number
IT1282219B1
IT1282219B1 IT95PD000244A ITPD950244A IT1282219B1 IT 1282219 B1 IT1282219 B1 IT 1282219B1 IT 95PD000244 A IT95PD000244 A IT 95PD000244A IT PD950244 A ITPD950244 A IT PD950244A IT 1282219 B1 IT1282219 B1 IT 1282219B1
Authority
IT
Italy
Prior art keywords
molecular weight
hyaluronic acid
low
preparation
pct
Prior art date
Application number
IT95PD000244A
Other languages
English (en)
Inventor
Davide Renier
Lanfranco Callegaro
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Publication of ITPD950244A0 publication Critical patent/ITPD950244A0/it
Priority to IT95PD000244A priority Critical patent/IT1282219B1/it
Priority to CZ19981889A priority patent/CZ291394B6/cs
Priority to IL12490996A priority patent/IL124909A/en
Priority to AU13749/97A priority patent/AU703332B2/en
Priority to HU9903666A priority patent/HU226949B1/hu
Priority to DE69604087T priority patent/DE69604087T2/de
Priority to SI9630118T priority patent/SI0868437T1/xx
Priority to PCT/EP1996/005701 priority patent/WO1997022629A1/en
Priority to JP52251197A priority patent/JP4094059B2/ja
Priority to IL14123096A priority patent/IL141230A/en
Priority to CA002240682A priority patent/CA2240682C/en
Priority to DK96944007T priority patent/DK0868437T3/da
Priority to US09/096,646 priority patent/US6020484A/en
Priority to EP96944007A priority patent/EP0868437B1/en
Priority to ES96944007T priority patent/ES2139402T3/es
Priority to AT96944007T priority patent/ATE184024T1/de
Publication of ITPD950244A1 publication Critical patent/ITPD950244A1/it
Application granted granted Critical
Publication of IT1282219B1 publication Critical patent/IT1282219B1/it
Priority to US09/426,536 priority patent/US6232303B1/en
Priority to GR990403066T priority patent/GR3031973T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IT95PD000244A 1995-12-20 1995-12-20 Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa IT1282219B1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT95PD000244A IT1282219B1 (it) 1995-12-20 1995-12-20 Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
JP52251197A JP4094059B2 (ja) 1995-12-20 1996-12-19 低い多分散指数を有するヒアルロン酸分画の調整方法
CA002240682A CA2240682C (en) 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index
AU13749/97A AU703332B2 (en) 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index
HU9903666A HU226949B1 (en) 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index
DE69604087T DE69604087T2 (de) 1995-12-20 1996-12-19 Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex
SI9630118T SI0868437T1 (en) 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index
PCT/EP1996/005701 WO1997022629A1 (en) 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index
CZ19981889A CZ291394B6 (cs) 1995-12-20 1996-12-19 Způsob přípravy frakce hyaluronové kyseliny s nízkým polydisperzním indexem
IL14123096A IL141230A (en) 1995-12-20 1996-12-19 Hyaluronic acid derivatives obtained from hyaluronic acid fraction having a low polydispersion index and pharmaceutical compositions and healthcare products containing them
IL12490996A IL124909A (en) 1995-12-20 1996-12-19 The process involving ultrasound and sodium hypochlorite in the preparation of a fraction of hyaluronic acid with a low polydispersity index
DK96944007T DK0868437T3 (da) 1995-12-20 1996-12-19 Fremgangsmåde til fremstilling af hyaluronsyrefraktion med et lavt polydispersionsindeks
US09/096,646 US6020484A (en) 1995-12-20 1996-12-19 Process for preparing a hyaluronic acid fraction having a low polydispersion index
EP96944007A EP0868437B1 (en) 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index
ES96944007T ES2139402T3 (es) 1995-12-20 1996-12-19 Un proceso para preparar una fraccion del acido hialuronico con un bajo indice de polidispersion.
AT96944007T ATE184024T1 (de) 1995-12-20 1996-12-19 Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex
US09/426,536 US6232303B1 (en) 1995-12-20 1999-10-26 Process for preparing a hyaluronic acid fraction having a low polydispersion index
GR990403066T GR3031973T3 (en) 1995-12-20 1999-11-29 A process for preparing a hyaluronic acid fraction having a low polydispersion index

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95PD000244A IT1282219B1 (it) 1995-12-20 1995-12-20 Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Publications (3)

Publication Number Publication Date
ITPD950244A0 ITPD950244A0 (it) 1995-12-20
ITPD950244A1 ITPD950244A1 (it) 1997-06-20
IT1282219B1 true IT1282219B1 (it) 1998-03-16

Family

ID=11391198

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95PD000244A IT1282219B1 (it) 1995-12-20 1995-12-20 Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Country Status (14)

Country Link
US (2) US6020484A (it)
EP (1) EP0868437B1 (it)
JP (1) JP4094059B2 (it)
AT (1) ATE184024T1 (it)
AU (1) AU703332B2 (it)
CZ (1) CZ291394B6 (it)
DE (1) DE69604087T2 (it)
DK (1) DK0868437T3 (it)
ES (1) ES2139402T3 (it)
GR (1) GR3031973T3 (it)
HU (1) HU226949B1 (it)
IL (1) IL124909A (it)
IT (1) IT1282219B1 (it)
WO (1) WO1997022629A1 (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
JPWO2003084571A1 (ja) * 2002-04-08 2005-08-11 電気化学工業株式会社 骨感染症治療用組成物
JP2005530768A (ja) * 2002-05-09 2005-10-13 メディジーンズ 血漿または血清を含有した創傷治療用医薬組成物
BR0310087A (pt) * 2002-05-17 2005-08-16 Wyeth Corp Veìculos sólidos injetáveis para ácido hialurÈnico para aplicação de proteìnas osteogênicas
WO2004004671A1 (en) * 2002-07-02 2004-01-15 Procyte Corporation Compositions containing peptide copper complexes and soft tissue fillers
US20060183709A1 (en) * 2005-02-15 2006-08-17 Ahmad Alkayali Preparation of low molecular weight hyaluronic acid as a food supplement
JP4576583B2 (ja) * 2005-03-22 2010-11-10 キユーピー株式会社 ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
US7323184B2 (en) * 2005-08-22 2008-01-29 Healagenics, Inc. Compositions and methods for the treatment of wounds and the reduction of scar formation
EP1992645A4 (en) 2006-02-24 2011-03-09 Q P Corp NOVEL HYALURONIC ACID WITH LOW MOLECULAR WEIGHT AND / OR SALT THEREOF, AND COSMETIC PREPARATION, PHARMACEUTICAL COMPOSITION AND EACH FOOD COMPOSITION USING THE SAME
EP2037874A1 (en) * 2006-06-28 2009-03-25 Novozymes Biopolymer A/S Compositions with several hyaluronic acid fractions for cosmetic and medical uses
WO2008003321A2 (en) * 2006-07-07 2008-01-10 Novozymes Biopolymer A/S Compositions with several hyaluronic acid fractions for cosmetic use
WO2008014787A1 (en) 2006-08-04 2008-02-07 Novozymes Biopolymer A/S Branched hyaluronic acid and method of manufacture
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
EP2209814B1 (en) * 2007-11-13 2017-01-25 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
US20130209531A1 (en) * 2010-06-08 2013-08-15 University Of Utah Research Foundation Applications of partially and fully sulfated hyaluronan
CN113512134B (zh) * 2021-07-30 2022-05-20 梅晔生物医药股份有限公司 一种全分子量分布的透明质酸钠及其制备方法和应用
JP7503278B1 (ja) 2024-02-09 2024-06-20 株式会社ブルー・スターR&D 低分子ヒアルロン酸の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
IN163192B (it) * 1983-10-11 1988-08-20 Fidia Spa
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
GB8713747D0 (en) * 1987-06-12 1987-07-15 Unilever Plc Skin treatment composition
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
JPH0675512B2 (ja) * 1989-03-20 1994-09-28 株式会社紀文食品 低重合度ヒアルロン酸アルカリ塩の製造方法
IT1247175B (it) * 1991-04-19 1994-12-12 Fidia Spa Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
IT1260148B (it) * 1992-04-17 1996-03-28 Fidia Spa Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
IT1268954B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Also Published As

Publication number Publication date
WO1997022629A1 (en) 1997-06-26
GR3031973T3 (en) 2000-03-31
ITPD950244A1 (it) 1997-06-20
DE69604087D1 (de) 1999-10-07
JP4094059B2 (ja) 2008-06-04
DK0868437T3 (da) 2000-03-13
US6232303B1 (en) 2001-05-15
ES2139402T3 (es) 2000-02-01
EP0868437A1 (en) 1998-10-07
ATE184024T1 (de) 1999-09-15
AU1374997A (en) 1997-07-14
EP0868437B1 (en) 1999-09-01
HU226949B1 (en) 2010-03-29
IL124909A (en) 2002-09-12
AU703332B2 (en) 1999-03-25
DE69604087T2 (de) 2000-02-24
CZ291394B6 (cs) 2003-02-12
HUP9903666A3 (en) 2001-03-28
US6020484A (en) 2000-02-01
JP2000502141A (ja) 2000-02-22
CZ188998A3 (cs) 1998-09-16
HUP9903666A2 (hu) 2000-03-28
IL124909A0 (en) 1999-01-26
ITPD950244A0 (it) 1995-12-20

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