ES2139402T3 - Un proceso para preparar una fraccion del acido hialuronico con un bajo indice de polidispersion. - Google Patents

Un proceso para preparar una fraccion del acido hialuronico con un bajo indice de polidispersion.

Info

Publication number
ES2139402T3
ES2139402T3 ES96944007T ES96944007T ES2139402T3 ES 2139402 T3 ES2139402 T3 ES 2139402T3 ES 96944007 T ES96944007 T ES 96944007T ES 96944007 T ES96944007 T ES 96944007T ES 2139402 T3 ES2139402 T3 ES 2139402T3
Authority
ES
Spain
Prior art keywords
hyaluronic acid
fraction
prepare
polydispersion index
low polydispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96944007T
Other languages
English (en)
Inventor
Lanfranco Callegaro
Davide Renier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anika Therapeutics SRL
Original Assignee
Fidia Advanced Biopolymers SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers SRL filed Critical Fidia Advanced Biopolymers SRL
Application granted granted Critical
Publication of ES2139402T3 publication Critical patent/ES2139402T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN PROCESO PARA PREPARAR UNA FRACCION DE ACIDO HIALURONICO CON UN PESO MOLECULAR PROMEDIO COMPRENDIDO ENTRE 5000 Y 300000 Y UN INDICE DE POLIDISPERSION INFERIOR A 1,7, QUE INCLUYE TRATAR EL ACIDO HIALURONICO DE ALTO PESO MOLECULAR DE PARTIDA, AL MISMO TIEMPO CON HIPOCLORITO SODICO Y CON ULTRASONIDOS.
ES96944007T 1995-12-20 1996-12-19 Un proceso para preparar una fraccion del acido hialuronico con un bajo indice de polidispersion. Expired - Lifetime ES2139402T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95PD000244A IT1282219B1 (it) 1995-12-20 1995-12-20 Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Publications (1)

Publication Number Publication Date
ES2139402T3 true ES2139402T3 (es) 2000-02-01

Family

ID=11391198

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96944007T Expired - Lifetime ES2139402T3 (es) 1995-12-20 1996-12-19 Un proceso para preparar una fraccion del acido hialuronico con un bajo indice de polidispersion.

Country Status (14)

Country Link
US (2) US6020484A (es)
EP (1) EP0868437B1 (es)
JP (1) JP4094059B2 (es)
AT (1) ATE184024T1 (es)
AU (1) AU703332B2 (es)
CZ (1) CZ291394B6 (es)
DE (1) DE69604087T2 (es)
DK (1) DK0868437T3 (es)
ES (1) ES2139402T3 (es)
GR (1) GR3031973T3 (es)
HU (1) HU226949B1 (es)
IL (1) IL124909A (es)
IT (1) IT1282219B1 (es)
WO (1) WO1997022629A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
WO2003084571A1 (fr) * 2002-04-08 2003-10-16 Denki Kagaku Kogyo Kabushiki Kaisha Composition therapeutique destinee aux maladies infectieuses des os
RU2308954C2 (ru) * 2002-05-09 2007-10-27 Медиджинез Фармацевтическая композиция для лечения ран, содержащая плазму или сыворотку крови
WO2003099992A2 (en) * 2002-05-17 2003-12-04 Wyeth Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
KR20050059003A (ko) * 2002-07-02 2005-06-17 프로사이트 코포레이션 펩티드 구리 착화합물 및 연조직 충전제를 함유하는조성물
US20060183709A1 (en) * 2005-02-15 2006-08-17 Ahmad Alkayali Preparation of low molecular weight hyaluronic acid as a food supplement
JP4576583B2 (ja) * 2005-03-22 2010-11-10 キユーピー株式会社 ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
US7323184B2 (en) * 2005-08-22 2008-01-29 Healagenics, Inc. Compositions and methods for the treatment of wounds and the reduction of scar formation
EP1992645A4 (en) * 2006-02-24 2011-03-09 Q P Corp NOVEL HYALURONIC ACID WITH LOW MOLECULAR WEIGHT AND / OR SALT THEREOF, AND COSMETIC PREPARATION, PHARMACEUTICAL COMPOSITION AND EACH FOOD COMPOSITION USING THE SAME
JP2009541372A (ja) * 2006-06-28 2009-11-26 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 複数のヒアルロン酸画分を含む化粧用と医療用の組成物
WO2008003321A2 (en) * 2006-07-07 2008-01-10 Novozymes Biopolymer A/S Compositions with several hyaluronic acid fractions for cosmetic use
CA2657823A1 (en) 2006-08-04 2008-02-07 Novozymes Biopolymer A/S Branched hyaluronic acid and method of manufacture
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
WO2009063291A1 (en) 2007-11-13 2009-05-22 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
US20130209531A1 (en) * 2010-06-08 2013-08-15 University Of Utah Research Foundation Applications of partially and fully sulfated hyaluronan
CN113512134B (zh) * 2021-07-30 2022-05-20 梅晔生物医药股份有限公司 一种全分子量分布的透明质酸钠及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
DE3482812D1 (de) * 1983-10-11 1990-08-30 Fidia Spa Fraktionen von hyaluronsaeure mit pharmazeutischer aktivitaet, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
GB8713747D0 (en) * 1987-06-12 1987-07-15 Unilever Plc Skin treatment composition
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
JPH0675512B2 (ja) * 1989-03-20 1994-09-28 株式会社紀文食品 低重合度ヒアルロン酸アルカリ塩の製造方法
IT1247175B (it) * 1991-04-19 1994-12-12 Fidia Spa Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
IT1260148B (it) * 1992-04-17 1996-03-28 Fidia Spa Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
IT1268954B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Also Published As

Publication number Publication date
CZ188998A3 (cs) 1998-09-16
AU703332B2 (en) 1999-03-25
EP0868437A1 (en) 1998-10-07
DE69604087D1 (de) 1999-10-07
JP2000502141A (ja) 2000-02-22
IT1282219B1 (it) 1998-03-16
GR3031973T3 (en) 2000-03-31
ITPD950244A0 (es) 1995-12-20
DE69604087T2 (de) 2000-02-24
DK0868437T3 (da) 2000-03-13
HU226949B1 (en) 2010-03-29
CZ291394B6 (cs) 2003-02-12
IL124909A (en) 2002-09-12
ITPD950244A1 (it) 1997-06-20
EP0868437B1 (en) 1999-09-01
HUP9903666A3 (en) 2001-03-28
JP4094059B2 (ja) 2008-06-04
US6232303B1 (en) 2001-05-15
ATE184024T1 (de) 1999-09-15
WO1997022629A1 (en) 1997-06-26
AU1374997A (en) 1997-07-14
HUP9903666A2 (hu) 2000-03-28
IL124909A0 (en) 1999-01-26
US6020484A (en) 2000-02-01

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