DE69604087D1 - Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex - Google Patents

Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex

Info

Publication number
DE69604087D1
DE69604087D1 DE69604087T DE69604087T DE69604087D1 DE 69604087 D1 DE69604087 D1 DE 69604087D1 DE 69604087 T DE69604087 T DE 69604087T DE 69604087 T DE69604087 T DE 69604087T DE 69604087 D1 DE69604087 D1 DE 69604087D1
Authority
DE
Germany
Prior art keywords
hyaluronic acid
pct
producing
acid fraction
polydispersion index
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69604087T
Other languages
English (en)
Other versions
DE69604087T2 (de
Inventor
Lanfranco Callegaro
Davide Renier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia Advanced Biopolymers SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers SRL filed Critical Fidia Advanced Biopolymers SRL
Publication of DE69604087D1 publication Critical patent/DE69604087D1/de
Application granted granted Critical
Publication of DE69604087T2 publication Critical patent/DE69604087T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69604087T 1995-12-20 1996-12-19 Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex Expired - Lifetime DE69604087T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95PD000244A IT1282219B1 (it) 1995-12-20 1995-12-20 Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
PCT/EP1996/005701 WO1997022629A1 (en) 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index

Publications (2)

Publication Number Publication Date
DE69604087D1 true DE69604087D1 (de) 1999-10-07
DE69604087T2 DE69604087T2 (de) 2000-02-24

Family

ID=11391198

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69604087T Expired - Lifetime DE69604087T2 (de) 1995-12-20 1996-12-19 Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex

Country Status (14)

Country Link
US (2) US6020484A (de)
EP (1) EP0868437B1 (de)
JP (1) JP4094059B2 (de)
AT (1) ATE184024T1 (de)
AU (1) AU703332B2 (de)
CZ (1) CZ291394B6 (de)
DE (1) DE69604087T2 (de)
DK (1) DK0868437T3 (de)
ES (1) ES2139402T3 (de)
GR (1) GR3031973T3 (de)
HU (1) HU226949B1 (de)
IL (1) IL124909A (de)
IT (1) IT1282219B1 (de)
WO (1) WO1997022629A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
JPWO2003084571A1 (ja) * 2002-04-08 2005-08-11 電気化学工業株式会社 骨感染症治療用組成物
US20050142208A1 (en) * 2002-05-09 2005-06-30 Won Min Yoo Pharmceutical composition for treatment of wounds conntaining blood plasma or serum
NZ536478A (en) * 2002-05-17 2008-02-29 Wyeth Corp Injectable or implantable solid, rod- shaped compositions for intraosseous delivery of osteogenic proteins
EP1534215A1 (de) * 2002-07-02 2005-06-01 Procyte Corporation Peptid-kupferkomplexe und weichgewebefüller enthaltende mittel
US20060183709A1 (en) * 2005-02-15 2006-08-17 Ahmad Alkayali Preparation of low molecular weight hyaluronic acid as a food supplement
JP4576583B2 (ja) * 2005-03-22 2010-11-10 キユーピー株式会社 ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
US7323184B2 (en) * 2005-08-22 2008-01-29 Healagenics, Inc. Compositions and methods for the treatment of wounds and the reduction of scar formation
JP5289936B2 (ja) * 2006-02-24 2013-09-11 キユーピー株式会社 新規な低分子ヒアルロン酸および／またはその塩、ならびにこれを用いた化粧料、医薬組成物および食品組成物
CA2654255A1 (en) * 2006-06-28 2008-01-03 Novozymes Biopolymer A/S Compositions with several hyaluronic acid fractions for cosmetic and medical uses
WO2008003321A2 (en) * 2006-07-07 2008-01-10 Novozymes Biopolymer A/S Compositions with several hyaluronic acid fractions for cosmetic use
EP2049572A1 (de) 2006-08-04 2009-04-22 Novozymes Biopolymer A/S Verzweigte hyaluronsäure und herstellungsverfahren dafür
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
ES2622834T3 (es) 2007-11-13 2017-07-07 Bio-Technology General (Israel) Ltd. Procedimiento de esterilización por filtración en estado diluido para biopolímeros viscoelásticos
US20130209531A1 (en) * 2010-06-08 2013-08-15 University Of Utah Research Foundation Applications of partially and fully sulfated hyaluronan
CN113512134B (zh) * 2021-07-30 2022-05-20 梅晔生物医药股份有限公司 一种全分子量分布的透明质酸钠及其制备方法和应用
JP7503278B1 (ja) 2024-02-09 2024-06-20 株式会社ブルー・スターR&D 低分子ヒアルロン酸の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
DE3482812D1 (de) * 1983-10-11 1990-08-30 Fidia Spa Fraktionen von hyaluronsaeure mit pharmazeutischer aktivitaet, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
GB8713747D0 (en) * 1987-06-12 1987-07-15 Unilever Plc Skin treatment composition
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
JPH0675512B2 (ja) * 1989-03-20 1994-09-28 株式会社紀文食品 低重合度ヒアルロン酸アルカリ塩の製造方法
IT1247175B (it) * 1991-04-19 1994-12-12 Fidia Spa Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
IT1260148B (it) * 1992-04-17 1996-03-28 Fidia Spa Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
IT1268954B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Also Published As

Publication number Publication date
ATE184024T1 (de) 1999-09-15
JP2000502141A (ja) 2000-02-22
IT1282219B1 (it) 1998-03-16
US6020484A (en) 2000-02-01
DE69604087T2 (de) 2000-02-24
EP0868437A1 (de) 1998-10-07
JP4094059B2 (ja) 2008-06-04
ITPD950244A1 (it) 1997-06-20
ITPD950244A0 (de) 1995-12-20
HUP9903666A2 (hu) 2000-03-28
IL124909A0 (en) 1999-01-26
HUP9903666A3 (en) 2001-03-28
WO1997022629A1 (en) 1997-06-26
DK0868437T3 (da) 2000-03-13
CZ291394B6 (cs) 2003-02-12
IL124909A (en) 2002-09-12
EP0868437B1 (de) 1999-09-01
AU1374997A (en) 1997-07-14
AU703332B2 (en) 1999-03-25
US6232303B1 (en) 2001-05-15
HU226949B1 (en) 2010-03-29
GR3031973T3 (en) 2000-03-31
CZ188998A3 (cs) 1998-09-16
ES2139402T3 (es) 2000-02-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: FIDIA FARMACEUTICI S.P.A., ABANO TERME, PADUA/PADO

8328 Change in the person/name/address of the agent

Representative=s name: SEITZ, R., DIPL.-ING.UNIV., PAT.-ANW., 80538 MUENC