ATE160352T1 - Verfahren zur herstellung von amino-1-hydroxy- alkyliden-1,1-bisphosphonsäuren - Google Patents
Verfahren zur herstellung von amino-1-hydroxy- alkyliden-1,1-bisphosphonsäurenInfo
- Publication number
- ATE160352T1 ATE160352T1 AT94927234T AT94927234T ATE160352T1 AT E160352 T1 ATE160352 T1 AT E160352T1 AT 94927234 T AT94927234 T AT 94927234T AT 94927234 T AT94927234 T AT 94927234T AT E160352 T1 ATE160352 T1 AT E160352T1
- Authority
- AT
- Austria
- Prior art keywords
- alkylidene
- hydroxy
- bisphosphonic acids
- producing amino
- producing
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11175193A | 1993-08-25 | 1993-08-25 | |
| US23964094A | 1994-05-09 | 1994-05-09 | |
| US08/286,151 US5510517A (en) | 1993-08-25 | 1994-08-04 | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE160352T1 true ATE160352T1 (de) | 1997-12-15 |
Family
ID=27381051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94927234T ATE160352T1 (de) | 1993-08-25 | 1994-08-24 | Verfahren zur herstellung von amino-1-hydroxy- alkyliden-1,1-bisphosphonsäuren |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5510517A (de) |
| EP (1) | EP0715631B1 (de) |
| JP (1) | JP3675818B2 (de) |
| KR (1) | KR100261202B1 (de) |
| CN (2) | CN1067079C (de) |
| AT (1) | ATE160352T1 (de) |
| AU (2) | AU692468B2 (de) |
| BR (1) | BR9407563A (de) |
| CA (1) | CA2169561C (de) |
| CY (1) | CY2086B1 (de) |
| CZ (1) | CZ290185B6 (de) |
| DE (1) | DE69406936T2 (de) |
| DK (1) | DK0715631T3 (de) |
| ES (1) | ES2109731T3 (de) |
| FI (1) | FI115526B (de) |
| GR (1) | GR3025450T3 (de) |
| HR (1) | HRP940479B1 (de) |
| HU (1) | HU217362B (de) |
| LV (1) | LV12189B (de) |
| NZ (1) | NZ273458A (de) |
| RO (1) | RO115524B1 (de) |
| RU (1) | RU2154647C2 (de) |
| SI (1) | SI0715631T1 (de) |
| WO (1) | WO1995006052A1 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5449819A (en) * | 1994-06-06 | 1995-09-12 | Merck & Co., Inc. | Process for removing waste pox, alendronate and its by products |
| US5589691A (en) * | 1994-06-06 | 1996-12-31 | Merck & Co., Inc. | Process for recovery and recycle of methanesulfonic acid and phosphorous acid |
| NZ334836A (en) * | 1996-10-04 | 2000-11-24 | Merck & Co Inc | Liquid alendronate formulations and their use in preventing bone resorption |
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| GB9800452D0 (en) * | 1998-01-10 | 1998-03-04 | Albright & Wilson | Preparation of phosphonic acid derivatives |
| US20030078211A1 (en) * | 1998-06-24 | 2003-04-24 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| WO1999067809A1 (en) | 1998-06-24 | 1999-12-29 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| US6331533B1 (en) | 1998-11-16 | 2001-12-18 | Merck & Co., Inc. | Method for inhibiting dental resorptive lesions |
| ES2153794B1 (es) * | 1999-08-06 | 2001-10-16 | Medichem Sa | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
| PE20011061A1 (es) | 2000-02-01 | 2001-11-20 | Procter & Gamble | Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato |
| US6562974B2 (en) | 2000-02-01 | 2003-05-13 | The Procter & Gamble Company | Process for making geminal bisphosphonates |
| ITMI20020908A1 (it) * | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione di sodio alendronato |
| BR0308901A (pt) * | 2002-05-10 | 2005-01-04 | Hoffmann La Roche | ácidos bisfosfÈnicos para tratamento e prevenção de osteoporose |
| ATE461205T1 (de) * | 2002-05-17 | 2010-04-15 | Teva Pharma | Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren |
| CA2487977A1 (en) * | 2002-06-06 | 2003-12-18 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases |
| JP4485117B2 (ja) * | 2002-06-27 | 2010-06-16 | 日東電工株式会社 | 保護剥離用フィルム |
| JP2006504679A (ja) * | 2002-08-28 | 2006-02-09 | メルク フロスト カナダ アンド カンパニー | 緑内障の治療においてｅｐ４受容体作動薬として使用するためのオキサゾリジン−２−オンおよびチアゾリジン−２−オン誘導体 |
| US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
| US20040206932A1 (en) * | 2002-12-30 | 2004-10-21 | Abuelyaman Ahmed S. | Compositions including polymerizable bisphosphonic acids and methods |
| US7452924B2 (en) * | 2003-08-12 | 2008-11-18 | 3M Espe Ag | Self-etching emulsion dental compositions and methods |
| CN1839114A (zh) | 2003-08-21 | 2006-09-27 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
| AU2004273672A1 (en) * | 2003-09-19 | 2005-03-31 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and a bisphosphonate |
| US7342060B2 (en) * | 2003-12-11 | 2008-03-11 | Dover Chemical Corporation | Process for manufacture of pentaerythritol diphosphites |
| US20050181043A1 (en) * | 2004-02-12 | 2005-08-18 | Indranil Nandi | Alendronate salt tablet compositions |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| AU2005269869B2 (en) * | 2004-07-08 | 2011-12-01 | 3M Innovative Properties Company | Dental methods, compositions, and kits including acid-sensitive dyes |
| AU2005272808B8 (en) * | 2004-08-11 | 2011-11-03 | 3M Deutschland Gmbh | Self-adhesive compositions including a plurality of acidic compounds |
| AU2006302797B2 (en) | 2005-03-02 | 2012-02-02 | Merck Canada Inc. | Composition for inhibition of cathepsin K |
| EP1883644A2 (de) * | 2005-05-06 | 2008-02-06 | Medichem, S.A. | Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof |
| US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
| AR058168A1 (es) * | 2005-11-07 | 2008-01-23 | Merck & Co Inc | Sintesis del alendronato de sodio trihidratado |
| WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| WO2007096896A1 (en) * | 2006-02-20 | 2007-08-30 | Alembic Limited | An improved process for the preparation of biphosphonic derivatives |
| EP2101716A2 (de) | 2006-12-13 | 2009-09-23 | 3M Innovative Properties Company | Verfahren zur verwendung einer dentalen zusammensetzung mit saurer komponente und lichtbleichbarem farbstoff |
| WO2008157050A1 (en) * | 2007-06-19 | 2008-12-24 | Albemarle Corporation | Processes for manufacturing bisphosphonic acids |
| CN101945853B (zh) | 2007-12-21 | 2014-08-20 | 配体药物公司 | 选择性雄激素受体调节剂(sarm)及其应用 |
| CN102124016A (zh) * | 2008-07-11 | 2011-07-13 | 斯索恩有限公司 | 制备1-羟基亚烷基-1，1-双膦酸的方法 |
| EP2192126B1 (de) | 2008-11-26 | 2013-03-27 | Synthon B.V. | Verfahren zur Herstellung von Zoledronsäure |
| US20100130746A1 (en) * | 2008-11-26 | 2010-05-27 | Martin Kas | Process for Making Zoledronic Acid |
| WO2011023280A1 (en) | 2009-08-28 | 2011-03-03 | Synthon B.V. | Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids |
| CA2778015C (en) * | 2009-10-26 | 2016-08-02 | Warner Chilcott Company, Llc | Bisphosphonate compounds for treating bone metabolism disorders |
| CA2738045C (en) | 2010-05-28 | 2019-02-19 | Simon Fraser University | Conjugate compounds, methods of making same, and uses thereof |
| US9592195B2 (en) | 2010-12-06 | 2017-03-14 | Effrx Pharmaceuticals Sa | Stable effervescent bisphosphonate formulations with rapid solubilization characteristics |
| EP2675440B1 (de) | 2011-02-14 | 2020-03-25 | Merck Sharp & Dohme Corp. | Cathepsin-cysteinproteasehemmer |
| FI20115315A0 (fi) * | 2011-04-01 | 2011-04-01 | Itae Suomen Yliopisto | Menetelmä metallien keräämiseksi |
| WO2015051479A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| RU2692799C2 (ru) | 2013-10-08 | 2019-06-27 | Мерк Шарп И Доум Корп. | Ингибиторы цистеинпротеаз катепсинов |
| WO2015120580A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| ES2864079T3 (es) | 2014-05-30 | 2021-10-13 | Pfizer | Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos |
| US9650414B1 (en) | 2014-05-30 | 2017-05-16 | Simon Fraser University | Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof |
| CN107849072B (zh) | 2015-06-12 | 2020-12-15 | 西蒙弗雷泽大学 | 酰胺连接的ep4激动剂-二膦酸盐化合物及其用途 |
| EP3827010B1 (de) | 2018-07-23 | 2025-08-27 | Brise Pharmaceuticals Co., Ltd. | Bisphosphonat-wirkstoff-konjugate |
| CN109456363A (zh) * | 2018-11-01 | 2019-03-12 | 南京海纳医药科技股份有限公司 | 一种米诺膦酸工艺杂质的制备方法 |
| AU2020257397B2 (en) | 2019-04-19 | 2026-02-26 | Ligand Pharmaceuticals Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| DD216465A1 (de) * | 1983-07-01 | 1984-12-12 | Agrochemie Piesteritz 4602 Wit | Verfahren zur herstellung substituierter alkanphosphonsaeuren |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
-
1994
- 1994-08-04 US US08/286,151 patent/US5510517A/en not_active Expired - Lifetime
- 1994-08-24 RU RU96107773/04A patent/RU2154647C2/ru active
- 1994-08-24 DE DE69406936T patent/DE69406936T2/de not_active Expired - Lifetime
- 1994-08-24 AU AU76743/94A patent/AU692468B2/en not_active Expired
- 1994-08-24 KR KR1019997012458A patent/KR100261202B1/ko not_active Expired - Lifetime
- 1994-08-24 RO RO96-00335A patent/RO115524B1/ro unknown
- 1994-08-24 HR HR940479A patent/HRP940479B1/xx not_active IP Right Cessation
- 1994-08-24 SI SI9430097T patent/SI0715631T1/xx unknown
- 1994-08-24 NZ NZ273458A patent/NZ273458A/en not_active IP Right Cessation
- 1994-08-24 WO PCT/US1994/009620 patent/WO1995006052A1/en not_active Ceased
- 1994-08-24 AT AT94927234T patent/ATE160352T1/de active
- 1994-08-24 JP JP50775895A patent/JP3675818B2/ja not_active Expired - Lifetime
- 1994-08-24 ES ES94927234T patent/ES2109731T3/es not_active Expired - Lifetime
- 1994-08-24 CA CA002169561A patent/CA2169561C/en not_active Expired - Fee Related
- 1994-08-24 CN CN94193725A patent/CN1067079C/zh not_active Expired - Lifetime
- 1994-08-24 DK DK94927234.8T patent/DK0715631T3/da active
- 1994-08-24 CZ CZ1996542A patent/CZ290185B6/cs not_active IP Right Cessation
- 1994-08-24 BR BR9407563A patent/BR9407563A/pt not_active IP Right Cessation
- 1994-08-24 EP EP94927234A patent/EP0715631B1/de not_active Expired - Lifetime
- 1994-08-24 HU HU9600429A patent/HU217362B/hu unknown
-
1996
- 1996-02-23 FI FI960851A patent/FI115526B/fi not_active IP Right Cessation
-
1997
- 1997-11-20 GR GR970402796T patent/GR3025450T3/el unknown
-
1998
- 1998-04-09 CY CY9800001A patent/CY2086B1/xx unknown
- 1998-08-12 AU AU79937/98A patent/AU714996B2/en not_active Expired
- 1998-10-12 LV LVP-98-213A patent/LV12189B/en unknown
-
2000
- 2000-08-03 CN CNB001225669A patent/CN1211392C/zh not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEFA | Change of the company name |