DE69431759D1 - Verfahren zur herstellung von n-methyl-3-(1-methyl-4-piperidinyl)-1h-indol-5-ethanesulfonamid - Google Patents
Verfahren zur herstellung von n-methyl-3-(1-methyl-4-piperidinyl)-1h-indol-5-ethanesulfonamidInfo
- Publication number
- DE69431759D1 DE69431759D1 DE69431759T DE69431759T DE69431759D1 DE 69431759 D1 DE69431759 D1 DE 69431759D1 DE 69431759 T DE69431759 T DE 69431759T DE 69431759 T DE69431759 T DE 69431759T DE 69431759 D1 DE69431759 D1 DE 69431759D1
- Authority
- DE
- Germany
- Prior art keywords
- methyl
- ethanesulfonamide
- indol
- piperidinyl
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- AMKVXSZCKVJAGH-UHFFFAOYSA-N naratriptan Chemical compound C12=CC(CCS(=O)(=O)NC)=CC=C2NC=C1C1CCN(C)CC1 AMKVXSZCKVJAGH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939320115A GB9320115D0 (en) | 1993-09-29 | 1993-09-29 | Process |
| PCT/EP1994/003216 WO1995009166A1 (en) | 1993-09-29 | 1994-09-27 | Process for the preparation of n-methyl-3-(1-methyl-4-piperidinyl)-14-indole-5-ethanesulphonamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69431759D1 true DE69431759D1 (de) | 2003-01-02 |
| DE69431759T2 DE69431759T2 (de) | 2003-07-03 |
Family
ID=10742727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69431759T Expired - Lifetime DE69431759T2 (de) | 1993-09-29 | 1994-09-27 | Verfahren zur herstellung von n-methyl-3-(1-methyl-4-piperidinyl)-1h-indol-5-ethanesulfonamid |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US5659040A (de) |
| EP (1) | EP0721453B1 (de) |
| JP (1) | JP3411284B2 (de) |
| CN (2) | CN1132509A (de) |
| AP (1) | AP529A (de) |
| AT (1) | ATE228124T1 (de) |
| AU (1) | AU682219B2 (de) |
| CA (1) | CA2170645C (de) |
| CO (1) | CO4290351A1 (de) |
| CZ (1) | CZ287581B6 (de) |
| DE (1) | DE69431759T2 (de) |
| DK (1) | DK0721453T3 (de) |
| ES (1) | ES2187534T3 (de) |
| FI (1) | FI111162B (de) |
| GB (1) | GB9320115D0 (de) |
| HK (1) | HK1004218A1 (de) |
| HR (1) | HRP940613B1 (de) |
| HU (1) | HU226828B1 (de) |
| IL (1) | IL111071A (de) |
| IS (1) | IS1877B (de) |
| MY (1) | MY117934A (de) |
| NO (1) | NO309324B1 (de) |
| NZ (1) | NZ274159A (de) |
| PE (1) | PE18195A1 (de) |
| PL (1) | PL178456B1 (de) |
| PT (1) | PT721453E (de) |
| RU (1) | RU2143428C1 (de) |
| SG (1) | SG49322A1 (de) |
| SI (1) | SI0721453T1 (de) |
| SK (1) | SK282234B6 (de) |
| WO (1) | WO1995009166A1 (de) |
| ZA (1) | ZA947516B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673827B1 (en) | 1999-06-29 | 2004-01-06 | The Uab Research Foundation | Methods of treating fungal infections with inhibitors of NAD synthetase enzyme |
| US6861448B2 (en) * | 1998-01-14 | 2005-03-01 | Virtual Drug Development, Inc. | NAD synthetase inhibitors and uses thereof |
| WO1999036422A1 (en) | 1998-01-14 | 1999-07-22 | The Uab Research Foundation | Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme |
| WO2006010079A2 (en) * | 2004-07-08 | 2006-01-26 | Dr. Reddy's Laboratories Ltd. | Process for preparing naratriptan hydrochloride |
| WO2006010078A2 (en) * | 2004-07-08 | 2006-01-26 | Dr. Reddy's Laboratories Ltd. | Polymorphic form of naratriptan hydrochloride |
| CN1315821C (zh) * | 2004-12-16 | 2007-05-16 | 上海美通生物科技有限公司 | 制备n－甲基－3－(1－甲基－4－哌啶基)－1,4－吲哚－5－乙硫胺的改进法 |
| WO2007050381A2 (en) * | 2005-10-24 | 2007-05-03 | Janssen Pharmaceutica, N.V. | 3-piperidin-4-yl-indole orl-1 receptor modulators |
| WO2009118753A2 (en) * | 2008-03-07 | 2009-10-01 | Usv Limited | Process for preparation of naratriptan hydrochloride |
| CN101676283A (zh) * | 2008-09-17 | 2010-03-24 | 北京德众万全药物技术开发有限公司 | 一种那拉曲坦的制备方法 |
| US8735589B2 (en) | 2009-08-20 | 2014-05-27 | Cipla Limited | Process for the synthesis of naratriptan |
| CN101792411B (zh) * | 2010-03-26 | 2012-05-30 | 常州晟永光电材料有限公司 | 一种合成乙磺酰胺的方法 |
| CN103073484B (zh) * | 2013-01-28 | 2014-10-22 | 山东诚创医药技术开发有限公司 | 一种甲哌卡因及其光学对映体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| PT88255B (pt) * | 1987-08-13 | 1995-03-01 | Glaxo Group Ltd | Processo para a preparacao de derivados do indole |
| GB8819024D0 (en) * | 1988-08-10 | 1988-09-14 | Glaxo Group Ltd | Chemical compounds |
| GB8903036D0 (en) * | 1989-02-10 | 1989-03-30 | Glaxo Group Ltd | Chemical compounds |
-
1993
- 1993-09-29 GB GB939320115A patent/GB9320115D0/en active Pending
-
1994
- 1994-09-26 IS IS4212A patent/IS1877B/is unknown
- 1994-09-26 PE PE1994251470A patent/PE18195A1/es not_active Application Discontinuation
- 1994-09-27 EP EP94928825A patent/EP0721453B1/de not_active Expired - Lifetime
- 1994-09-27 SG SG1996009269A patent/SG49322A1/en unknown
- 1994-09-27 DE DE69431759T patent/DE69431759T2/de not_active Expired - Lifetime
- 1994-09-27 CN CN94193590A patent/CN1132509A/zh active Pending
- 1994-09-27 HR HR940613A patent/HRP940613B1/xx not_active IP Right Cessation
- 1994-09-27 ZA ZA947516A patent/ZA947516B/xx unknown
- 1994-09-27 MY MYPI94002565A patent/MY117934A/en unknown
- 1994-09-27 NZ NZ274159A patent/NZ274159A/en not_active IP Right Cessation
- 1994-09-27 US US08/600,932 patent/US5659040A/en not_active Expired - Lifetime
- 1994-09-27 CA CA002170645A patent/CA2170645C/en not_active Expired - Fee Related
- 1994-09-27 WO PCT/EP1994/003216 patent/WO1995009166A1/en active IP Right Grant
- 1994-09-27 CZ CZ1996768A patent/CZ287581B6/cs not_active IP Right Cessation
- 1994-09-27 CO CO94043932A patent/CO4290351A1/es unknown
- 1994-09-27 PL PL94313740A patent/PL178456B1/pl not_active IP Right Cessation
- 1994-09-27 DK DK94928825T patent/DK0721453T3/da active
- 1994-09-27 RU RU96108268A patent/RU2143428C1/ru not_active IP Right Cessation
- 1994-09-27 JP JP51011095A patent/JP3411284B2/ja not_active Expired - Lifetime
- 1994-09-27 SK SK406-96A patent/SK282234B6/sk not_active IP Right Cessation
- 1994-09-27 AT AT94928825T patent/ATE228124T1/de active
- 1994-09-27 AU AU78101/94A patent/AU682219B2/en not_active Expired
- 1994-09-27 HU HU9600814A patent/HU226828B1/hu not_active IP Right Cessation
- 1994-09-27 PT PT94928825T patent/PT721453E/pt unknown
- 1994-09-27 ES ES94928825T patent/ES2187534T3/es not_active Expired - Lifetime
- 1994-09-27 SI SI9430433T patent/SI0721453T1/xx unknown
- 1994-09-28 IL IL11107194A patent/IL111071A/en not_active IP Right Cessation
- 1994-09-28 AP APAP/P/1994/000676A patent/AP529A/en active
-
1996
- 1996-03-26 FI FI961378A patent/FI111162B/fi not_active IP Right Cessation
- 1996-03-28 NO NO961252A patent/NO309324B1/no not_active IP Right Cessation
-
1997
- 1997-03-19 US US08/820,833 patent/US5786473A/en not_active Expired - Lifetime
-
1998
- 1998-04-24 HK HK98103467A patent/HK1004218A1/xx not_active IP Right Cessation
-
2000
- 2000-07-12 CN CN00120229A patent/CN1332166A/zh active Pending
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |