DE69406936D1 - Verfahren zur herstellung von amino-1-hydroxy-alkyliden-1,1-bisphosphonsäuren - Google Patents
Verfahren zur herstellung von amino-1-hydroxy-alkyliden-1,1-bisphosphonsäurenInfo
- Publication number
- DE69406936D1 DE69406936D1 DE69406936T DE69406936T DE69406936D1 DE 69406936 D1 DE69406936 D1 DE 69406936D1 DE 69406936 T DE69406936 T DE 69406936T DE 69406936 T DE69406936 T DE 69406936T DE 69406936 D1 DE69406936 D1 DE 69406936D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyliden
- hydroxy
- bisphosphonic acids
- producing amino
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11175193A | 1993-08-25 | 1993-08-25 | |
| US23964094A | 1994-05-09 | 1994-05-09 | |
| US08/286,151 US5510517A (en) | 1993-08-25 | 1994-08-04 | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
| PCT/US1994/009620 WO1995006052A1 (en) | 1993-08-25 | 1994-08-24 | Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69406936D1 true DE69406936D1 (de) | 1998-01-02 |
| DE69406936T2 DE69406936T2 (de) | 1998-06-04 |
Family
ID=27381051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69406936T Expired - Lifetime DE69406936T2 (de) | 1993-08-25 | 1994-08-24 | Verfahren zur herstellung von amino-1-hydroxy-alkyliden-1,1-bisphosphonsäuren |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5510517A (de) |
| EP (1) | EP0715631B1 (de) |
| JP (1) | JP3675818B2 (de) |
| KR (1) | KR100261202B1 (de) |
| CN (2) | CN1067079C (de) |
| AT (1) | ATE160352T1 (de) |
| AU (2) | AU692468B2 (de) |
| BR (1) | BR9407563A (de) |
| CA (1) | CA2169561C (de) |
| CY (1) | CY2086B1 (de) |
| CZ (1) | CZ290185B6 (de) |
| DE (1) | DE69406936T2 (de) |
| DK (1) | DK0715631T3 (de) |
| ES (1) | ES2109731T3 (de) |
| FI (1) | FI115526B (de) |
| GR (1) | GR3025450T3 (de) |
| HK (1) | HK1008883A1 (de) |
| HR (1) | HRP940479B1 (de) |
| HU (1) | HU217362B (de) |
| LV (1) | LV12189B (de) |
| NZ (1) | NZ273458A (de) |
| RO (1) | RO115524B1 (de) |
| RU (1) | RU2154647C2 (de) |
| SI (1) | SI0715631T1 (de) |
| WO (1) | WO1995006052A1 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5449819A (en) * | 1994-06-06 | 1995-09-12 | Merck & Co., Inc. | Process for removing waste pox, alendronate and its by products |
| US5589691A (en) * | 1994-06-06 | 1996-12-31 | Merck & Co., Inc. | Process for recovery and recycle of methanesulfonic acid and phosphorous acid |
| BR9712197A (pt) * | 1996-10-04 | 1999-08-31 | Merck & Co Inc | Formulação farmacêutica líquida aquosa e processos de preparação da mesma, e, de inibição de reabsorção de osso. |
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| GB9800452D0 (en) | 1998-01-10 | 1998-03-04 | Albright & Wilson | Preparation of phosphonic acid derivatives |
| US20030078211A1 (en) * | 1998-06-24 | 2003-04-24 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| US6432931B1 (en) | 1998-06-24 | 2002-08-13 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| US6331533B1 (en) | 1998-11-16 | 2001-12-18 | Merck & Co., Inc. | Method for inhibiting dental resorptive lesions |
| ES2153794B1 (es) | 1999-08-06 | 2001-10-16 | Medichem Sa | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
| PE20011065A1 (es) | 2000-02-01 | 2001-11-21 | Procter & Gamble | Proceso para fabricar bisfosfonatos geminales |
| US6410520B2 (en) | 2000-02-01 | 2002-06-25 | The Procter & Gamble Company | Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate |
| ITMI20020908A1 (it) * | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione di sodio alendronato |
| KR20060058151A (ko) * | 2002-05-10 | 2006-05-29 | 에프. 호프만-라 로슈 아게 | 골다공증 치료 및 예방용 비스포스폰산 |
| DE60331724D1 (de) * | 2002-05-17 | 2010-04-29 | Teva Pharma | Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren |
| WO2003103664A1 (en) * | 2002-06-06 | 2003-12-18 | Merck Frosst Canada & Co. | 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases |
| JP4485117B2 (ja) * | 2002-06-27 | 2010-06-16 | 日東電工株式会社 | 保護剥離用フィルム |
| AU2003258433A1 (en) * | 2002-08-28 | 2004-03-19 | Merck Frosst Canada Ltd | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma |
| US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
| US20040206932A1 (en) * | 2002-12-30 | 2004-10-21 | Abuelyaman Ahmed S. | Compositions including polymerizable bisphosphonic acids and methods |
| EP1653913B1 (de) * | 2003-08-12 | 2012-05-23 | 3M Innovative Properties Company | Selbstätzende dentalzusammensetzungen und verfahren |
| AU2004266740B2 (en) | 2003-08-21 | 2010-08-26 | Merck Frosst Canada Ltd | Cathepsin cysteine protease inhibitors |
| MXPA06003063A (es) * | 2003-09-19 | 2006-05-31 | Pfizer Prod Inc | Composiciones farmaceuticas y metodos que comprenden combinaciones de derivados de 2-alquiliden-19-nor-vitamina- d y un bisfosfonato. |
| US20050181043A1 (en) * | 2004-02-12 | 2005-08-18 | Indranil Nandi | Alendronate salt tablet compositions |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| US8465284B2 (en) * | 2004-07-08 | 2013-06-18 | 3M Innovative Properties Company | Dental methods, compositions, and kits including acid-sensitive dyes |
| KR101260525B1 (ko) * | 2004-08-11 | 2013-05-06 | 쓰리엠 도이칠란드 게엠베하 | 다수의 산성 화합물을 포함하는 자체-접착성 조성물 |
| US8722734B2 (en) | 2005-03-02 | 2014-05-13 | Merck Sharp & Dohme Corp. | Composition for inhibition of cathepsin K |
| EP1883644A2 (de) * | 2005-05-06 | 2008-02-06 | Medichem, S.A. | Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof |
| US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
| AR058168A1 (es) * | 2005-11-07 | 2008-01-23 | Merck & Co Inc | Sintesis del alendronato de sodio trihidratado |
| WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| EP1987046A1 (de) * | 2006-02-20 | 2008-11-05 | Alembic Limited | Verbessertes verfahren zur herstellung von biphosphonderivaten |
| WO2008076739A2 (en) | 2006-12-13 | 2008-06-26 | 3M Innovative Properties Company | Methods of using a dental composition having an acidic component and a photobleachable dye |
| CA2689504A1 (en) * | 2007-06-19 | 2008-12-24 | Albemarle Corporation | Processes for manufacturing bisphosphonic acids |
| PT2222636E (pt) | 2007-12-21 | 2013-07-16 | Ligand Pharm Inc | Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações |
| CN102124016A (zh) | 2008-07-11 | 2011-07-13 | 斯索恩有限公司 | 制备1-羟基亚烷基-1，1-双膦酸的方法 |
| EP2192126B1 (de) | 2008-11-26 | 2013-03-27 | Synthon B.V. | Verfahren zur Herstellung von Zoledronsäure |
| US20100130746A1 (en) * | 2008-11-26 | 2010-05-27 | Martin Kas | Process for Making Zoledronic Acid |
| EA201270328A1 (ru) | 2009-08-28 | 2012-09-28 | Синтон Б. В. | Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот |
| EP2493905B1 (de) * | 2009-10-26 | 2016-11-30 | Warner Chilcott Company, LLC | Bisphosphonatverbindungen zur behandlung von gestörtem knochenmetabolismus |
| CA2738045C (en) | 2010-05-28 | 2019-02-19 | Simon Fraser University | Conjugate compounds, methods of making same, and uses thereof |
| EP2648702B1 (de) | 2010-12-06 | 2019-03-06 | Effrx Pharmaceuticals SA | Stabile bisphosphonat-brauseformulierungen mit schneller löslichkeit |
| EP2675440B1 (de) | 2011-02-14 | 2020-03-25 | Merck Sharp & Dohme Corp. | Cathepsin-cysteinproteasehemmer |
| FI20115315A0 (fi) * | 2011-04-01 | 2011-04-01 | Itae Suomen Yliopisto | Menetelmä metallien keräämiseksi |
| WO2015054089A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2015051479A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2015120580A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| US9650414B1 (en) | 2014-05-30 | 2017-05-16 | Simon Fraser University | Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof |
| US10328082B2 (en) | 2014-05-30 | 2019-06-25 | Pfizer Inc. | Methods of use and combinations |
| EP3307747A4 (de) | 2015-06-12 | 2019-02-27 | Simon Fraser University | Amid-verlinkte ep4-agonist-bisphosphonatverbindungen und verwendungen davon |
| CN112867724A (zh) | 2018-07-23 | 2021-05-28 | 广州噢斯荣医药技术有限公司 | 二膦酸盐药物缀合物 |
| CN109456363A (zh) * | 2018-11-01 | 2019-03-12 | 南京海纳医药科技股份有限公司 | 一种米诺膦酸工艺杂质的制备方法 |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| DD216465A1 (de) * | 1983-07-01 | 1984-12-12 | Agrochemie Piesteritz 4602 Wit | Verfahren zur herstellung substituierter alkanphosphonsaeuren |
| US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
-
1994
- 1994-08-04 US US08/286,151 patent/US5510517A/en not_active Expired - Lifetime
- 1994-08-24 DE DE69406936T patent/DE69406936T2/de not_active Expired - Lifetime
- 1994-08-24 KR KR1019997012458A patent/KR100261202B1/ko not_active IP Right Cessation
- 1994-08-24 RO RO96-00335A patent/RO115524B1/ro unknown
- 1994-08-24 DK DK94927234.8T patent/DK0715631T3/da active
- 1994-08-24 SI SI9430097T patent/SI0715631T1/xx unknown
- 1994-08-24 CA CA002169561A patent/CA2169561C/en not_active Expired - Fee Related
- 1994-08-24 AU AU76743/94A patent/AU692468B2/en not_active Expired
- 1994-08-24 HU HU9600429A patent/HU217362B/hu unknown
- 1994-08-24 CN CN94193725A patent/CN1067079C/zh not_active Expired - Lifetime
- 1994-08-24 JP JP50775895A patent/JP3675818B2/ja not_active Expired - Lifetime
- 1994-08-24 ES ES94927234T patent/ES2109731T3/es not_active Expired - Lifetime
- 1994-08-24 AT AT94927234T patent/ATE160352T1/de active
- 1994-08-24 RU RU96107773/04A patent/RU2154647C2/ru active
- 1994-08-24 EP EP94927234A patent/EP0715631B1/de not_active Expired - Lifetime
- 1994-08-24 HR HR940479A patent/HRP940479B1/xx not_active IP Right Cessation
- 1994-08-24 WO PCT/US1994/009620 patent/WO1995006052A1/en active IP Right Grant
- 1994-08-24 BR BR9407563A patent/BR9407563A/pt not_active IP Right Cessation
- 1994-08-24 CZ CZ1996542A patent/CZ290185B6/cs not_active IP Right Cessation
- 1994-08-24 NZ NZ273458A patent/NZ273458A/en not_active IP Right Cessation
-
1996
- 1996-02-23 FI FI960851A patent/FI115526B/fi not_active IP Right Cessation
-
1997
- 1997-11-20 GR GR970402796T patent/GR3025450T3/el unknown
-
1998
- 1998-04-09 CY CY9800001A patent/CY2086B1/xx unknown
- 1998-08-03 HK HK98109618A patent/HK1008883A1/xx not_active IP Right Cessation
- 1998-08-12 AU AU79937/98A patent/AU714996B2/en not_active Expired
- 1998-10-12 LV LVP-98-213A patent/LV12189B/en unknown
-
2000
- 2000-08-03 CN CNB001225669A patent/CN1211392C/zh not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US |
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Ref document number: 715631 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., 07065-0900 RAHWAY, US Effective date: 20121213 |
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