DE69406936D1 - Verfahren zur herstellung von amino-1-hydroxy-alkyliden-1,1-bisphosphonsäuren - Google Patents
Verfahren zur herstellung von amino-1-hydroxy-alkyliden-1,1-bisphosphonsäurenInfo
- Publication number
- DE69406936D1 DE69406936D1 DE69406936T DE69406936T DE69406936D1 DE 69406936 D1 DE69406936 D1 DE 69406936D1 DE 69406936 T DE69406936 T DE 69406936T DE 69406936 T DE69406936 T DE 69406936T DE 69406936 D1 DE69406936 D1 DE 69406936D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyliden
- hydroxy
- bisphosphonic acids
- producing amino
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11175193A | 1993-08-25 | 1993-08-25 | |
| US23964094A | 1994-05-09 | 1994-05-09 | |
| US08/286,151 US5510517A (en) | 1993-08-25 | 1994-08-04 | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
| PCT/US1994/009620 WO1995006052A1 (en) | 1993-08-25 | 1994-08-24 | Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69406936D1 true DE69406936D1 (de) | 1998-01-02 |
| DE69406936T2 DE69406936T2 (de) | 1998-06-04 |
Family
ID=27381051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69406936T Expired - Lifetime DE69406936T2 (de) | 1993-08-25 | 1994-08-24 | Verfahren zur herstellung von amino-1-hydroxy-alkyliden-1,1-bisphosphonsäuren |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5510517A (de) |
| EP (1) | EP0715631B1 (de) |
| JP (1) | JP3675818B2 (de) |
| KR (1) | KR100261202B1 (de) |
| CN (2) | CN1067079C (de) |
| AT (1) | ATE160352T1 (de) |
| AU (2) | AU692468B2 (de) |
| BR (1) | BR9407563A (de) |
| CA (1) | CA2169561C (de) |
| CY (1) | CY2086B1 (de) |
| CZ (1) | CZ290185B6 (de) |
| DE (1) | DE69406936T2 (de) |
| DK (1) | DK0715631T3 (de) |
| ES (1) | ES2109731T3 (de) |
| FI (1) | FI115526B (de) |
| GR (1) | GR3025450T3 (de) |
| HK (1) | HK1008883A1 (de) |
| HR (1) | HRP940479B1 (de) |
| HU (1) | HU217362B (de) |
| LV (1) | LV12189B (de) |
| NZ (1) | NZ273458A (de) |
| RO (1) | RO115524B1 (de) |
| RU (1) | RU2154647C2 (de) |
| SI (1) | SI0715631T1 (de) |
| WO (1) | WO1995006052A1 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5449819A (en) * | 1994-06-06 | 1995-09-12 | Merck & Co., Inc. | Process for removing waste pox, alendronate and its by products |
| US5589691A (en) * | 1994-06-06 | 1996-12-31 | Merck & Co., Inc. | Process for recovery and recycle of methanesulfonic acid and phosphorous acid |
| AU723357B2 (en) * | 1996-10-04 | 2000-08-24 | Merck & Co., Inc. | Liquid alendronate formulations |
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| GB9800452D0 (en) * | 1998-01-10 | 1998-03-04 | Albright & Wilson | Preparation of phosphonic acid derivatives |
| US6432931B1 (en) | 1998-06-24 | 2002-08-13 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| US20030078211A1 (en) * | 1998-06-24 | 2003-04-24 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| US6331533B1 (en) | 1998-11-16 | 2001-12-18 | Merck & Co., Inc. | Method for inhibiting dental resorptive lesions |
| ES2153794B1 (es) * | 1999-08-06 | 2001-10-16 | Medichem Sa | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
| US6562974B2 (en) | 2000-02-01 | 2003-05-13 | The Procter & Gamble Company | Process for making geminal bisphosphonates |
| US6410520B2 (en) | 2000-02-01 | 2002-06-25 | The Procter & Gamble Company | Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate |
| ITMI20020908A1 (it) * | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione di sodio alendronato |
| KR20120065435A (ko) * | 2002-05-10 | 2012-06-20 | 에프. 호프만-라 로슈 아게 | 골다공증 치료 및 예방용 비스포스폰산 |
| ATE461205T1 (de) * | 2002-05-17 | 2010-04-15 | Teva Pharma | Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren |
| JP2005534653A (ja) * | 2002-06-06 | 2005-11-17 | メルク フロスト カナダ アンド カンパニー | 眼及び骨疾患の治療に於いてｅｐ４受容体作動薬として使用するための１，５−二置換イミダゾリジン−２−オン誘導体 |
| JP4485117B2 (ja) * | 2002-06-27 | 2010-06-16 | 日東電工株式会社 | 保護剥離用フィルム |
| EP1545517A1 (de) * | 2002-08-28 | 2005-06-29 | Merck Frosst Canada & Co. | Oxazolidin-2-on und thiazolidin-2-on-derivate zur verwendung als ep4-rezeptor-agonisten bei der behandlung von glaukom |
| US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
| US20040206932A1 (en) * | 2002-12-30 | 2004-10-21 | Abuelyaman Ahmed S. | Compositions including polymerizable bisphosphonic acids and methods |
| WO2005018581A2 (en) * | 2003-08-12 | 2005-03-03 | 3M Innovative Properties Company | Self-etching dental compositions and methods |
| EP1673336B1 (de) | 2003-08-21 | 2014-06-04 | Merck Canada Inc. | Cathepsincysteinproteasehemmer |
| CA2539359A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate |
| US20050181043A1 (en) * | 2004-02-12 | 2005-08-18 | Indranil Nandi | Alendronate salt tablet compositions |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| CA2573020A1 (en) * | 2004-07-08 | 2006-02-09 | 3M Innovative Properties Company | Dental methods, compositions, and kits including acid-sensitive dyes |
| EP1784155B1 (de) * | 2004-08-11 | 2011-09-28 | 3M Innovative Properties Company | Selbstklebende zusammensetzungen mit einer vielzahl von sauren verbindungen |
| EP1855674B1 (de) | 2005-03-02 | 2014-07-16 | Merck Sharp & Dohme Corp. | Zusammensetzung zur hemmung von cathepsin k |
| CA2606879A1 (en) * | 2005-05-06 | 2007-03-01 | Medichem, S.A. | Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof |
| US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
| AR058168A1 (es) * | 2005-11-07 | 2008-01-23 | Merck & Co Inc | Sintesis del alendronato de sodio trihidratado |
| WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| WO2007096896A1 (en) * | 2006-02-20 | 2007-08-30 | Alembic Limited | An improved process for the preparation of biphosphonic derivatives |
| EP2101716A2 (de) | 2006-12-13 | 2009-09-23 | 3M Innovative Properties Company | Verfahren zur verwendung einer dentalen zusammensetzung mit saurer komponente und lichtbleichbarem farbstoff |
| WO2008157050A1 (en) * | 2007-06-19 | 2008-12-24 | Albemarle Corporation | Processes for manufacturing bisphosphonic acids |
| EP2489656A1 (de) | 2007-12-21 | 2012-08-22 | Ligand Pharmaceuticals Inc. | Selektive Androgenrezeptormodulatoren (SARMS) und ihre Verwendung |
| US8026388B2 (en) * | 2008-07-11 | 2011-09-27 | Synthon Bv | Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids |
| US20100130746A1 (en) * | 2008-11-26 | 2010-05-27 | Martin Kas | Process for Making Zoledronic Acid |
| EP2192126B1 (de) | 2008-11-26 | 2013-03-27 | Synthon B.V. | Verfahren zur Herstellung von Zoledronsäure |
| EA201270328A1 (ru) | 2009-08-28 | 2012-09-28 | Синтон Б. В. | Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот |
| EP2493905B1 (de) | 2009-10-26 | 2016-11-30 | Warner Chilcott Company, LLC | Bisphosphonatverbindungen zur behandlung von gestörtem knochenmetabolismus |
| CA2738045C (en) | 2010-05-28 | 2019-02-19 | Simon Fraser University | Conjugate compounds, methods of making same, and uses thereof |
| BR112013010476B1 (pt) | 2010-12-06 | 2021-07-06 | Effrx Pharmaceuticals Sa | formulações efervescentes estáveis de bisfosfonato com características de solubilização rápida |
| EP2675440B1 (de) | 2011-02-14 | 2020-03-25 | Merck Sharp & Dohme Corp. | Cathepsin-cysteinproteasehemmer |
| FI20115315A0 (fi) * | 2011-04-01 | 2011-04-01 | Itae Suomen Yliopisto | Menetelmä metallien keräämiseksi |
| CN105593230B (zh) | 2013-10-08 | 2018-07-06 | 默沙东公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
| WO2015051479A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2015120580A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| KR20160147007A (ko) | 2014-05-30 | 2016-12-21 | 화이자 인코포레이티드 | 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체 |
| US9650414B1 (en) | 2014-05-30 | 2017-05-16 | Simon Fraser University | Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof |
| CN107849072B (zh) | 2015-06-12 | 2020-12-15 | 西蒙弗雷泽大学 | 酰胺连接的ep4激动剂-二膦酸盐化合物及其用途 |
| EP3827010A4 (de) | 2018-07-23 | 2022-03-16 | Brise Pharmaceuticals Co., Ltd. | Bisphosphonat-wirkstoff-konjugate |
| CN109456363A (zh) * | 2018-11-01 | 2019-03-12 | 南京海纳医药科技股份有限公司 | 一种米诺膦酸工艺杂质的制备方法 |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| DD216465A1 (de) * | 1983-07-01 | 1984-12-12 | Agrochemie Piesteritz 4602 Wit | Verfahren zur herstellung substituierter alkanphosphonsaeuren |
| US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
-
1994
- 1994-08-04 US US08/286,151 patent/US5510517A/en not_active Expired - Lifetime
- 1994-08-24 KR KR1019997012458A patent/KR100261202B1/ko not_active IP Right Cessation
- 1994-08-24 RU RU96107773/04A patent/RU2154647C2/ru active
- 1994-08-24 WO PCT/US1994/009620 patent/WO1995006052A1/en active IP Right Grant
- 1994-08-24 HU HU9600429A patent/HU217362B/hu unknown
- 1994-08-24 EP EP94927234A patent/EP0715631B1/de not_active Expired - Lifetime
- 1994-08-24 DE DE69406936T patent/DE69406936T2/de not_active Expired - Lifetime
- 1994-08-24 SI SI9430097T patent/SI0715631T1/xx unknown
- 1994-08-24 NZ NZ273458A patent/NZ273458A/en not_active IP Right Cessation
- 1994-08-24 JP JP50775895A patent/JP3675818B2/ja not_active Expired - Lifetime
- 1994-08-24 CZ CZ1996542A patent/CZ290185B6/cs not_active IP Right Cessation
- 1994-08-24 HR HR940479A patent/HRP940479B1/xx not_active IP Right Cessation
- 1994-08-24 RO RO96-00335A patent/RO115524B1/ro unknown
- 1994-08-24 DK DK94927234.8T patent/DK0715631T3/da active
- 1994-08-24 AU AU76743/94A patent/AU692468B2/en not_active Expired
- 1994-08-24 CA CA002169561A patent/CA2169561C/en not_active Expired - Fee Related
- 1994-08-24 AT AT94927234T patent/ATE160352T1/de active
- 1994-08-24 ES ES94927234T patent/ES2109731T3/es not_active Expired - Lifetime
- 1994-08-24 CN CN94193725A patent/CN1067079C/zh not_active Expired - Lifetime
- 1994-08-24 BR BR9407563A patent/BR9407563A/pt not_active IP Right Cessation
-
1996
- 1996-02-23 FI FI960851A patent/FI115526B/fi not_active IP Right Cessation
-
1997
- 1997-11-20 GR GR970402796T patent/GR3025450T3/el unknown
-
1998
- 1998-04-09 CY CY9800001A patent/CY2086B1/xx unknown
- 1998-08-03 HK HK98109618A patent/HK1008883A1/xx not_active IP Right Cessation
- 1998-08-12 AU AU79937/98A patent/AU714996B2/en not_active Expired
- 1998-10-12 LV LVP-98-213A patent/LV12189B/en unknown
-
2000
- 2000-08-03 CN CNB001225669A patent/CN1211392C/zh not_active Expired - Lifetime
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Legal Events
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US |
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| R081 | Change of applicant/patentee |
Ref document number: 715631 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., 07065-0900 RAHWAY, US Effective date: 20121213 |
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