CY2086B1 - Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acids - Google Patents

Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acids

Info

Publication number
CY2086B1
CY2086B1 CY9800001A CY9800001A CY2086B1 CY 2086 B1 CY2086 B1 CY 2086B1 CY 9800001 A CY9800001 A CY 9800001A CY 9800001 A CY9800001 A CY 9800001A CY 2086 B1 CY2086 B1 CY 2086B1
Authority
CY
Cyprus
Prior art keywords
producing
amino
idene
hydroxy
alkyl
Prior art date
Application number
CY9800001A
Other languages
English (en)
Inventor
Richard R Dauer
Lisa Dimichele
Mauricio Futran
Gerard R Kieczykowski
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27381051&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2086(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CY2086B1 publication Critical patent/CY2086B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CY9800001A 1993-08-25 1998-04-09 Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acids CY2086B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11175193A 1993-08-25 1993-08-25
US23964094A 1994-05-09 1994-05-09
US08/286,151 US5510517A (en) 1993-08-25 1994-08-04 Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

Publications (1)

Publication Number Publication Date
CY2086B1 true CY2086B1 (en) 2002-04-05

Family

ID=27381051

Family Applications (1)

Application Number Title Priority Date Filing Date
CY9800001A CY2086B1 (en) 1993-08-25 1998-04-09 Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acids

Country Status (24)

Country Link
US (1) US5510517A (de)
EP (1) EP0715631B1 (de)
JP (1) JP3675818B2 (de)
KR (1) KR100261202B1 (de)
CN (2) CN1067079C (de)
AT (1) ATE160352T1 (de)
AU (2) AU692468B2 (de)
BR (1) BR9407563A (de)
CA (1) CA2169561C (de)
CY (1) CY2086B1 (de)
CZ (1) CZ290185B6 (de)
DE (1) DE69406936T2 (de)
DK (1) DK0715631T3 (de)
ES (1) ES2109731T3 (de)
FI (1) FI115526B (de)
GR (1) GR3025450T3 (de)
HR (1) HRP940479B1 (de)
HU (1) HU217362B (de)
LV (1) LV12189B (de)
NZ (1) NZ273458A (de)
RO (1) RO115524B1 (de)
RU (1) RU2154647C2 (de)
SI (1) SI0715631T1 (de)
WO (1) WO1995006052A1 (de)

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US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
AU757104B2 (en) 1998-06-24 2003-01-30 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
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US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
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ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
KR20140021045A (ko) * 2002-05-10 2014-02-19 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
CN1665825A (zh) * 2002-05-17 2005-09-07 特瓦制药工业有限公司 用一定的稀释剂制备双膦酸
AU2003233731A1 (en) * 2002-06-06 2003-12-22 Xavier Billot 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
WO2004019938A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
AU2004266623B8 (en) * 2003-08-12 2011-10-27 3M Deutschland Gmbh Self-etching dental compositions and methods
JP4553899B2 (ja) 2003-08-21 2010-09-29 メルク フロスト カナダ リミテツド カテプシンシステインプロテアーゼ阻害剤
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US7342060B2 (en) * 2003-12-11 2008-03-11 Dover Chemical Corporation Process for manufacture of pentaerythritol diphosphites
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
JP5214242B2 (ja) * 2004-07-08 2013-06-19 スリーエム イノベイティブ プロパティズ カンパニー 歯科用の方法、組成物、および酸感受性色素を含むキット
US8722760B2 (en) * 2004-08-11 2014-05-13 3M Innovative Properties Company Self-adhesive compositions including a plurality of acidic compounds
PT1855674E (pt) 2005-03-02 2014-10-08 Merck Canada Inc Composição para a inibição de catepsina k
AR057291A1 (es) * 2005-05-06 2007-11-28 Medichem Sa Proceso para la preparacion de acidos bisfosfonicos geminales y las sales y/o hidratos farmaceuticamente aceptables de los mismos, una composicion farmaceutica que los contiene y el uso de esta en el tratamiento de la osteoporosis
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WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
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JP5507256B2 (ja) 2006-12-13 2014-05-28 スリーエム イノベイティブ プロパティズ カンパニー 酸性成分及び光退色性染料を有する歯科用組成物の使用方法
WO2008157050A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
EP2489656A1 (de) 2007-12-21 2012-08-22 Ligand Pharmaceuticals Inc. Selektive Androgenrezeptormodulatoren (SARMS) und ihre Verwendung
US8026388B2 (en) * 2008-07-11 2011-09-27 Synthon Bv Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
EP2192126B1 (de) 2008-11-26 2013-03-27 Synthon B.V. Verfahren zur Herstellung von Zoledronsäure
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
EP2470549B1 (de) 2009-08-28 2014-07-16 Synthon B.V. Verfahren zur herstellung von hydroxyalkyliden-1,1-biphosphonsäuren
US8314081B2 (en) * 2009-10-26 2012-11-20 Warner Chilcott Company, Llc Bisphosphonate compounds
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
WO2012078528A2 (en) 2010-12-06 2012-06-14 Effrx Pharmaceuticals Sa Stable effervescent bisphosphonate formulations with rapid solubilization characteristics
EP2675440B1 (de) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin-cysteinproteasehemmer
FI20115315A0 (fi) * 2011-04-01 2011-04-01 Itae Suomen Yliopisto Menetelmä metallien keräämiseksi
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
JP6454335B2 (ja) 2013-10-08 2019-01-16 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． カテプシンシステインプロテアーゼ阻害剤
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JP6649902B2 (ja) 2014-05-30 2020-02-19 ファイザー・インク 選択的アンドロゲン受容体モジュレーターとしてのカルボニトリル誘導体
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
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Also Published As

Publication number Publication date
JP3675818B2 (ja) 2005-07-27
HU217362B (hu) 2000-01-28
ATE160352T1 (de) 1997-12-15
FI960851L (fi) 1996-02-23
BR9407563A (pt) 1996-12-31
RO115524B1 (ro) 2000-03-30
EP0715631A1 (de) 1996-06-12
AU7993798A (en) 1998-10-15
HRP940479A2 (en) 1997-02-28
DK0715631T3 (da) 1997-12-22
CN1134703A (zh) 1996-10-30
CA2169561A1 (en) 1995-03-02
CN1067079C (zh) 2001-06-13
AU7674394A (en) 1995-03-21
HU9600429D0 (en) 1996-04-29
WO1995006052A1 (en) 1995-03-02
DE69406936T2 (de) 1998-06-04
HRP940479B1 (en) 2000-10-31
AU692468B2 (en) 1998-06-11
SI0715631T1 (en) 1998-02-28
NZ273458A (en) 1998-04-27
GR3025450T3 (en) 1998-02-27
KR100261202B1 (ko) 2000-07-01
AU714996B2 (en) 2000-01-13
US5510517A (en) 1996-04-23
LV12189B (en) 1999-02-20
RU2154647C2 (ru) 2000-08-20
FI960851A0 (fi) 1996-02-23
HUT75261A (en) 1997-05-28
HK1008883A1 (en) 1999-05-21
LV12189A (lv) 1998-12-20
ES2109731T3 (es) 1998-01-16
EP0715631B1 (de) 1997-11-19
CN1308082A (zh) 2001-08-15
CZ54296A3 (en) 1996-10-16
DE69406936D1 (de) 1998-01-02
JPH09501935A (ja) 1997-02-25
FI115526B (fi) 2005-05-31
CZ290185B6 (cs) 2002-06-12
CN1211392C (zh) 2005-07-20
CA2169561C (en) 2007-02-20

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