IT1268954B1 - Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche - Google Patents
Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceuticheInfo
- Publication number
- IT1268954B1 IT1268954B1 IT1994PD000042A ITPD940042A IT1268954B1 IT 1268954 B1 IT1268954 B1 IT 1268954B1 IT 1994PD000042 A IT1994PD000042 A IT 1994PD000042A IT PD940042 A ITPD940042 A IT PD940042A IT 1268954 B1 IT1268954 B1 IT 1268954B1
- Authority
- IT
- Italy
- Prior art keywords
- preparation
- pharmaceutical compositions
- hyaluronic acid
- enzymatic synthesis
- related pharmaceutical
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 229920002674 hyaluronan Polymers 0.000 title 1
- 229960003160 hyaluronic acid Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Materials Engineering (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1994PD000042A IT1268954B1 (it) | 1994-03-11 | 1994-03-11 | Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche |
| PCT/EP1995/000935 WO1995024497A2 (en) | 1994-03-11 | 1995-03-10 | Enzymatic preparation of polysaccharides |
| AU20699/95A AU2069995A (en) | 1994-03-11 | 1995-03-10 | Enzymatic preparation of polysaccharides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1994PD000042A IT1268954B1 (it) | 1994-03-11 | 1994-03-11 | Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITPD940042A0 ITPD940042A0 (it) | 1994-03-11 |
| ITPD940042A1 ITPD940042A1 (it) | 1995-09-11 |
| IT1268954B1 true IT1268954B1 (it) | 1997-03-18 |
Family
ID=11390593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1994PD000042A IT1268954B1 (it) | 1994-03-11 | 1994-03-11 | Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2069995A (it) |
| IT (1) | IT1268954B1 (it) |
| WO (1) | WO1995024497A2 (it) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462606B2 (en) | 2002-03-12 | 2008-12-09 | Fidia Farmaceutici S.P.A. | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455304B1 (en) | 1994-07-01 | 2002-09-24 | The Board Of Regents Of The University Of Oklahoma | Hyaluronate synthase gene and uses thereof |
| US7091008B1 (en) | 1994-07-01 | 2006-08-15 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase genes and expression thereof in Bacillus hosts |
| US6951743B2 (en) | 1997-10-31 | 2005-10-04 | University Of Oklahoma Board Of Regents | Hyaluronan synthase genes and expression thereof in bacillus hosts |
| WO1997020061A1 (en) * | 1995-11-30 | 1997-06-05 | The Scripps Research Institute | Synthesis of hyaluronic acid |
| IT1282219B1 (it) * | 1995-12-20 | 1998-03-16 | Fidia Advanced Biopolymers Srl | Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa |
| EP0861903A1 (en) * | 1997-02-22 | 1998-09-02 | Lansing, Manfred | Method for reversible immobilizing oligo and/or polysaccharides |
| DE69828193T2 (de) | 1997-10-31 | 2005-12-01 | The Board Of Regents Of The University Of Oklahoma, Norman | Hyaluronan synthase gen und seine verwendung |
| CN101113436B (zh) | 1997-10-31 | 2013-02-06 | 俄克拉何马大学董事会 | 透明质酸合酶基因及其应用 |
| US7223571B2 (en) | 1998-04-02 | 2007-05-29 | The Board Of Regents Of The Universtiy Of Oklahoma | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
| US20060188966A1 (en) | 1998-04-02 | 2006-08-24 | Deangelis Paul L | Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same |
| US7060469B2 (en) | 1998-04-02 | 2006-06-13 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
| US6987023B2 (en) | 1998-04-02 | 2006-01-17 | The Board Of Regents Of The University Of Oklahoma | DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use |
| AU774722B2 (en) * | 1998-04-02 | 2004-07-08 | Board Of Regents Of The University Of Oklahoma, The | Polymer grafting by polysaccharide synthases |
| US7094581B2 (en) | 1998-10-26 | 2006-08-22 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthases and methods of making and using same |
| IL143080A0 (en) | 1998-11-11 | 2002-04-21 | Univ Oklahoma | Polymer grafting by polysaccharide synthases |
| US7642071B2 (en) | 1999-04-01 | 2010-01-05 | The Board Of Regents Of The University Of Oklahoma | Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts |
| JP2003503160A (ja) * | 1999-06-30 | 2003-01-28 | ノバルティス アクチエンゲゼルシャフト | 眼科用成形物 |
| US7534589B2 (en) | 1999-11-10 | 2009-05-19 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
| KR100501584B1 (ko) | 2000-02-03 | 2005-07-18 | (주)케이비피 | 저분자 폴리만유로네이트의 제조방법, 혈청지질개선제로서의 이의 신규 용도 및 이를 함유하는 기능성식품 및 건강 보조 식품 |
| WO2004033472A1 (de) * | 2002-10-09 | 2004-04-22 | Westfälische Wilhelms-Universität Münster | Verfahren zur herstellung von monomeren uronsäuren, insbesondere d-mannuronsäure und d-guluronsäure, derivaten davon und deren verwendung als arzneimittel |
| DE10247073B4 (de) * | 2002-10-09 | 2010-08-05 | Mirshafiey, Abbas, Prof. Dr. | Verfahren zur Herstellung von monomeren Uronsäuren, insbesondere D-Mannuronsäure und D-Guluronsäure und deren Verwendung als Arzneimittel |
| WO2009063291A1 (en) | 2007-11-13 | 2009-05-22 | Bio-Technology General (Israel) Ltd. | Dilute filtration sterilization process for viscoelastic biopolymers |
| ITMI20072348A1 (it) * | 2007-12-17 | 2009-06-18 | Medichem Srl | Metodo per la rigenerazione cellulare di acido ialuronico e relativa composizione cosmetica |
| EP3184552B1 (en) | 2008-09-02 | 2020-08-12 | Tautona Group LP | Threads of hyaluronic acid, methods of making thereof and uses thereof |
| CN111676258A (zh) * | 2020-07-13 | 2020-09-18 | 南京恒道医药科技有限公司 | 一种连续制备分离玻璃酸钠的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO161573C (no) * | 1983-11-25 | 1989-08-30 | Miles Inc | Fremgangsmaate til fremstilling av hyaluronsyre. |
| CA2106301C (en) * | 1991-03-18 | 1999-04-06 | Chi-Huey Wong | Oligosaccharide enzyme substrates and inhibitors: method and compositions |
| CA2121365C (en) * | 1991-10-15 | 2000-11-28 | Chi-Huey Wong | Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of gdp-fucose |
| IT1260154B (it) * | 1992-07-03 | 1996-03-28 | Lanfranco Callegaro | Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) |
-
1994
- 1994-03-11 IT IT1994PD000042A patent/IT1268954B1/it active IP Right Grant
-
1995
- 1995-03-10 AU AU20699/95A patent/AU2069995A/en not_active Abandoned
- 1995-03-10 WO PCT/EP1995/000935 patent/WO1995024497A2/en active Application Filing
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462606B2 (en) | 2002-03-12 | 2008-12-09 | Fidia Farmaceutici S.P.A. | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
| US8178499B2 (en) | 2002-03-12 | 2012-05-15 | Fidia Farmaceutici S.P.A. | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
| US8178663B2 (en) | 2002-03-12 | 2012-05-15 | Fidia Farmaceutici S.P.A. | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995024497A3 (en) | 1995-11-16 |
| ITPD940042A0 (it) | 1994-03-11 |
| AU2069995A (en) | 1995-09-25 |
| ITPD940042A1 (it) | 1995-09-11 |
| WO1995024497A2 (en) | 1995-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970221 |