IT1247175B - Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. - Google Patents

Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.

Info

Publication number
IT1247175B
IT1247175B ITPD910077A ITPD910077A IT1247175B IT 1247175 B IT1247175 B IT 1247175B IT PD910077 A ITPD910077 A IT PD910077A IT PD910077 A ITPD910077 A IT PD910077A IT 1247175 B IT1247175 B IT 1247175B
Authority
IT
Italy
Prior art keywords
hyaluronic acid
fraction
purification
procedure
pure
Prior art date
Application number
ITPD910077A
Other languages
English (en)
Inventor
Aurelio Romeo
Silvana Lorenzi
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11389548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1247175(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fidia Spa filed Critical Fidia Spa
Priority to ITPD910077A priority Critical patent/IT1247175B/it
Publication of ITPD910077A0 publication Critical patent/ITPD910077A0/it
Priority to BR9205240A priority patent/BR9205240A/pt
Priority to HU9204012A priority patent/HU215193B/hu
Priority to SG1996005472A priority patent/SG46515A1/en
Priority to ES92908628T priority patent/ES2092971T3/es
Priority to KR1019920703262A priority patent/KR0178544B1/ko
Priority to AU15766/92A priority patent/AU653022B2/en
Priority to PL92297297A priority patent/PL168477B1/pl
Priority to EP92908628A priority patent/EP0535200B1/en
Priority to PCT/EP1992/000861 priority patent/WO1992018543A1/en
Priority to IL10161192A priority patent/IL101611A/en
Priority to AT92908628T priority patent/ATE186307T1/de
Priority to CS923771A priority patent/CZ282248B6/cs
Priority to CA002084875A priority patent/CA2084875C/en
Priority to DK92908628T priority patent/DK0535200T3/da
Priority to DE69230242T priority patent/DE69230242T2/de
Priority to JP4507997A priority patent/JP2580458B2/ja
Priority to RU92016520A priority patent/RU2128666C1/ru
Priority to SK3771-92A priority patent/SK280191B6/sk
Publication of ITPD910077A1 publication Critical patent/ITPD910077A1/it
Priority to NO924873A priority patent/NO305520B1/no
Priority to FI925756A priority patent/FI104973B/fi
Priority to UA93002144A priority patent/UA27229C2/uk
Publication of IT1247175B publication Critical patent/IT1247175B/it
Application granted granted Critical
Priority to IL11345395A priority patent/IL113453A0/xx
Priority to US08/439,437 priority patent/US5559104A/en
Priority to GR20000400131T priority patent/GR3032434T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invenzione ha per oggetto un nuovo procedimento per la preparazione di frazioni molto pure di acido ialuronico e dei suoi sali. Inoltre l'invenzione comprende una frazione specifica di acido ialuronico e suoi sali, in particolare il suo sale sodico, ottenibile con questo procedimento ed avente un peso molecolare mediocompreso in un intervallo ristretto di grandezze.Tale frazione (denominata "HYALOFTIL") trova un'interessante applicazione in chirurgia oftalmica: infatti il prodotto viene ottimamente tollerato, non è infiammatorio e non causa complicazioni post-operatorie. Inoltre il prodotto ha il vantaggio notevole di poter essere lasciato in situ dopo intervento chirurgico, senza indurre complicazioni post-operatorie.
ITPD910077A 1991-04-19 1991-04-19 Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. IT1247175B (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
ITPD910077A IT1247175B (it) 1991-04-19 1991-04-19 Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
SK3771-92A SK280191B6 (sk) 1991-04-19 1992-04-16 Frakcia kyseliny hyalurónovej, spôsob výroby frakc
AT92908628T ATE186307T1 (de) 1991-04-19 1992-04-16 Verfahren zur reinigung von hyaluronsäure und fraktion von reiner hyaluronsäurezur ophthalmischen verwendung.
DK92908628T DK0535200T3 (da) 1991-04-19 1992-04-16 Fremgangsmåde til oprensning af hyaluronsyre og fraktion af ren hyaluronsyre til oftalmiskanvendelse
SG1996005472A SG46515A1 (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
ES92908628T ES2092971T3 (es) 1991-04-19 1992-04-16 Procedimiento para la purificacion de acido hialuronico y fraccion de acido hialuronico puro para utilizacion oftalmologica.
KR1019920703262A KR0178544B1 (ko) 1991-04-19 1992-04-16 안과용 순수 히알우론산 분류물 및 그의 정제방법
AU15766/92A AU653022B2 (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
PL92297297A PL168477B1 (pl) 1991-04-19 1992-04-16 Sposób otrzymywania frakcji kwasu hialuronowego, sposób otrzymywania frakcji hialuronianu sodu oraz sposób oczyszczania kwasu hialuronowego lub jego soli PL PL PL PL PL PL
EP92908628A EP0535200B1 (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
PCT/EP1992/000861 WO1992018543A1 (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
IL10161192A IL101611A (en) 1991-04-19 1992-04-16 Process for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
BR9205240A BR9205240A (pt) 1991-04-19 1992-04-16 Procedimento para a purificacao de acido hialuronico e fracao de acido hialuronico puro para uso oftalmico
CS923771A CZ282248B6 (cs) 1991-04-19 1992-04-16 Způsob čištění kyseliny hyaluronové a frakce čisté kyseliny hyaluronové pro oftalmologické použití
CA002084875A CA2084875C (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
HU9204012A HU215193B (hu) 1991-04-19 1992-04-16 Eljárás szemészeti célra alkalmazható nagy tisztaságú hialuronsav-frakció és az ezt tartalmazó gyógyszerkészítmények előállítására
DE69230242T DE69230242T2 (de) 1991-04-19 1992-04-16 Verfahren zur Reinigung von Hyaluronsäure und Fraktion von reiner Hyaluronsäurezur ophthalmischen Verwendung.
JP4507997A JP2580458B2 (ja) 1991-04-19 1992-04-16 ヒアルロン酸の精製方法および眼科用の純粋なヒアルロン酸の分画
RU92016520A RU2128666C1 (ru) 1991-04-19 1992-04-16 Фракция гиалуроновой кислоты или ее соли, способ очистки этой фракции, способы получения этой фракции, фармацевтический препарат и средства, используемые в офтальмологии
NO924873A NO305520B1 (no) 1991-04-19 1992-12-16 FremgangsmÕte til rensing av hyaluronsyre og fraksjon av ren hyaluronsyre til oftalmologisk anvendelse
FI925756A FI104973B (fi) 1991-04-19 1992-12-18 Menetelmä hyaluronihapon puhdistamiseksi
UA93002144A UA27229C2 (uk) 1991-04-19 1993-06-16 Фракція гіалуронової кислоти або її солі для застосування в офтальмології, спосіб одержання фракції натрієвої солі гіалуронової кислоти та фармацевтичний препарат для використання в офтальмології
IL11345395A IL113453A0 (en) 1991-04-19 1995-04-20 Procedure for the purification of hydraluronic acid and fraction of pure hyaluronic acid for ophthalmic use
US08/439,437 US5559104A (en) 1991-04-19 1995-05-11 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
GR20000400131T GR3032434T3 (en) 1991-04-19 2000-01-19 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD910077A IT1247175B (it) 1991-04-19 1991-04-19 Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.

Publications (3)

Publication Number Publication Date
ITPD910077A0 ITPD910077A0 (it) 1991-04-19
ITPD910077A1 ITPD910077A1 (it) 1992-10-19
IT1247175B true IT1247175B (it) 1994-12-12

Family

ID=11389548

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD910077A IT1247175B (it) 1991-04-19 1991-04-19 Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.

Country Status (24)

Country Link
US (1) US5559104A (it)
EP (1) EP0535200B1 (it)
JP (1) JP2580458B2 (it)
KR (1) KR0178544B1 (it)
AT (1) ATE186307T1 (it)
AU (1) AU653022B2 (it)
BR (1) BR9205240A (it)
CA (1) CA2084875C (it)
CZ (1) CZ282248B6 (it)
DE (1) DE69230242T2 (it)
DK (1) DK0535200T3 (it)
ES (1) ES2092971T3 (it)
FI (1) FI104973B (it)
GR (1) GR3032434T3 (it)
HU (1) HU215193B (it)
IL (2) IL101611A (it)
IT (1) IT1247175B (it)
NO (1) NO305520B1 (it)
PL (1) PL168477B1 (it)
RU (1) RU2128666C1 (it)
SG (1) SG46515A1 (it)
SK (1) SK280191B6 (it)
UA (1) UA27229C2 (it)
WO (1) WO1992018543A1 (it)

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IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
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CN103442721A (zh) * 2011-03-02 2013-12-11 电气化学工业株式会社 含透明质酸或透明质酸盐的水溶液
JP5957442B2 (ja) * 2011-03-02 2016-07-27 デンカ株式会社 樹脂製バレルを有するシリンジ内にヒアルロン酸又はその塩を含む水溶液を充填してなるプレフィルドシリンジ
WO2012118193A1 (ja) * 2011-03-02 2012-09-07 電気化学工業株式会社 ヒアルロン酸またはその塩を含む水溶液
US9522162B2 (en) 2011-03-23 2016-12-20 University Of Utah Research Foundation Methods for treating or preventing urological inflammation
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ATE186307T1 (de) 1999-11-15
FI925756L (fi) 1992-12-18
BR9205240A (pt) 1993-08-31
PL168477B1 (pl) 1996-02-29
CZ282248B6 (cs) 1997-06-11
DE69230242D1 (de) 1999-12-09
WO1992018543A1 (en) 1992-10-29
JP2580458B2 (ja) 1997-02-12
IL101611A (en) 1996-06-18
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SK377192A3 (en) 1995-06-07
ES2092971T1 (es) 1996-12-16
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AU1576692A (en) 1992-11-17
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EP0535200A1 (en) 1993-04-07
AU653022B2 (en) 1994-09-15
ITPD910077A0 (it) 1991-04-19
HU215193B (hu) 1998-10-28
US5559104A (en) 1996-09-24
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