DK2838918T3 - Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler - Google Patents

Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler Download PDF

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Publication number
DK2838918T3
DK2838918T3 DK13720615.7T DK13720615T DK2838918T3 DK 2838918 T3 DK2838918 T3 DK 2838918T3 DK 13720615 T DK13720615 T DK 13720615T DK 2838918 T3 DK2838918 T3 DK 2838918T3
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methods
molecules
heterodimer
preparing
preparing heterodimer
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DK13720615.7T
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Danish (da)
English (en)
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Kruif Cornelis Adriaan De
Linda Johanna Aleida Hendriks
Ton Logtenberg
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Merus Nv
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1278—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK13720615.7T 2012-04-20 2013-04-19 Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler DK2838918T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261635935P 2012-04-20 2012-04-20
PCT/NL2013/050294 WO2013157954A1 (en) 2012-04-20 2013-04-19 Methods and means for the production of ig-like molecules

Publications (1)

Publication Number Publication Date
DK2838918T3 true DK2838918T3 (da) 2019-08-12

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ID=48289584

Family Applications (2)

Application Number Title Priority Date Filing Date
DK13720614.0T DK2838917T3 (da) 2012-04-20 2013-04-19 Fremgangsmåder og midler til frembringelse af heterodimere ig-lignende molekyler
DK13720615.7T DK2838918T3 (da) 2012-04-20 2013-04-19 Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler

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DK13720614.0T DK2838917T3 (da) 2012-04-20 2013-04-19 Fremgangsmåder og midler til frembringelse af heterodimere ig-lignende molekyler

Country Status (24)

Country Link
US (12) US20150196637A1 (enExample)
EP (4) EP2838917B1 (enExample)
JP (9) JP6393255B2 (enExample)
KR (9) KR102545770B1 (enExample)
CN (6) CN104520320B (enExample)
AU (4) AU2013249985B2 (enExample)
CA (2) CA2870821C (enExample)
CY (2) CY1122153T1 (enExample)
DK (2) DK2838917T3 (enExample)
EA (3) EA201491908A1 (enExample)
ES (2) ES2740749T3 (enExample)
HR (2) HRP20191446T1 (enExample)
HU (2) HUE045944T2 (enExample)
LT (2) LT2838918T (enExample)
MX (7) MX360109B (enExample)
NZ (4) NZ772318A (enExample)
PL (2) PL2838917T3 (enExample)
PT (2) PT2838917T (enExample)
RS (2) RS59260B1 (enExample)
SG (6) SG10201913634VA (enExample)
SI (2) SI2838917T1 (enExample)
SM (2) SMT201900493T1 (enExample)
WO (2) WO2013157954A1 (enExample)
ZA (2) ZA201407835B (enExample)

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SMT201900493T1 (it) 2019-11-13
JP2019022489A (ja) 2019-02-14
SG10201607371UA (en) 2016-10-28
US12123043B2 (en) 2024-10-22
EA202090591A3 (ru) 2020-12-30
KR20150035535A (ko) 2015-04-06
US20210071222A1 (en) 2021-03-11
CN104520319A (zh) 2015-04-15
ES2743399T3 (es) 2020-02-19
US9758805B2 (en) 2017-09-12
US20240344102A1 (en) 2024-10-17
PL2838918T3 (pl) 2019-11-29
SG11201406770WA (en) 2014-11-27
MX2024012548A (es) 2024-12-06
EP2838918B1 (en) 2019-06-05
PT2838918T (pt) 2019-08-23
HUE045945T2 (hu) 2020-02-28
JP2025109759A (ja) 2025-07-25
EP2838918A1 (en) 2015-02-25
LT2838918T (lt) 2019-09-10
AU2018201325B2 (en) 2020-02-06
MX2018012766A (es) 2021-11-16
JP2024180421A (ja) 2024-12-26
CN107383197A (zh) 2017-11-24
KR102545770B1 (ko) 2023-06-21
MX2014012700A (es) 2014-12-05
NZ630568A (en) 2017-06-30
US20230340556A1 (en) 2023-10-26
JP2020089366A (ja) 2020-06-11
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EP3594232A1 (en) 2020-01-15
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CN104520319B (zh) 2017-08-25
US20140140999A1 (en) 2014-05-22
JP6639464B2 (ja) 2020-02-05
MX360109B (es) 2018-10-23
AU2018201326A1 (en) 2018-03-15
CA2870821C (en) 2022-06-14
US20150196637A1 (en) 2015-07-16
SG11201406772YA (en) 2014-11-27
JP6781740B2 (ja) 2020-11-04
DK2838917T3 (da) 2019-08-26
KR20220046711A (ko) 2022-04-14
SMT201900488T1 (it) 2019-11-13
MX2025005214A (es) 2025-08-01
ES2740749T3 (es) 2020-02-06
KR20200126007A (ko) 2020-11-05
NZ799532A (en) 2023-07-28
EA201491908A1 (ru) 2015-03-31
KR102269650B1 (ko) 2021-06-28
US20170327860A1 (en) 2017-11-16
US9248181B2 (en) 2016-02-02
JP6272299B2 (ja) 2018-01-31
JP2015515275A (ja) 2015-05-28
SI2838918T1 (sl) 2019-11-29
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PL2838917T3 (pl) 2019-12-31
NZ772318A (en) 2023-06-30
NZ728228A (en) 2021-02-26
EP3594233A1 (en) 2020-01-15
ZA201407834B (en) 2015-12-23
AU2013249986B2 (en) 2017-11-23
CA2870821A1 (en) 2013-10-24
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CN107383197B (zh) 2021-12-10
JP6393255B2 (ja) 2018-09-19
JP2023060019A (ja) 2023-04-27
US20140072579A1 (en) 2014-03-13
HRP20191446T1 (hr) 2019-11-15
JP2020202854A (ja) 2020-12-24
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NZ630551A (en) 2017-11-24
CN104520320A (zh) 2015-04-15
AU2013249986A1 (en) 2014-11-06
US20150139996A1 (en) 2015-05-21
PT2838917T (pt) 2019-09-12
KR20200047724A (ko) 2020-05-07
KR20250025034A (ko) 2025-02-20
MX2014012701A (es) 2014-12-05
CA2871068A1 (en) 2013-10-24
HK1206039A1 (en) 2015-12-31
US20170369923A1 (en) 2017-12-28
SG10201607369QA (en) 2016-10-28
KR102104601B1 (ko) 2020-06-01
SI2838917T1 (sl) 2019-11-29
HK1206041A1 (en) 2015-12-31
ZA201407835B (en) 2015-12-23
EA035344B1 (ru) 2020-05-29
KR20150035534A (ko) 2015-04-06
HUE045944T2 (hu) 2020-02-28
CN114163530A (zh) 2022-03-11
CN104520320B (zh) 2018-05-01
EA201491909A1 (ru) 2015-03-31
AU2018201326B2 (en) 2020-02-06
NZ802035A (en) 2025-02-28
US20200017897A1 (en) 2020-01-16
US20130336981A1 (en) 2013-12-19
CA2871068C (en) 2022-06-14
EA202090591A2 (ru) 2020-08-31
WO2013157953A1 (en) 2013-10-24
JP7723694B2 (ja) 2025-08-14
RS59260B1 (sr) 2019-10-31
US20160177364A1 (en) 2016-06-23
AU2018201325A1 (en) 2018-03-15
CY1122118T1 (el) 2020-11-25
JP2018099119A (ja) 2018-06-28
SG10201913376XA (en) 2020-02-27
US9358286B2 (en) 2016-06-07
KR102382304B1 (ko) 2022-04-04
KR20200015756A (ko) 2020-02-12
US10752929B2 (en) 2020-08-25
MX2018012769A (es) 2021-11-16
AU2013249985A1 (en) 2014-11-06
AU2013249985B2 (en) 2017-11-23
KR20230093359A (ko) 2023-06-27
HRP20191409T1 (hr) 2019-11-15
US10329596B2 (en) 2019-06-25
JP7743173B2 (ja) 2025-09-24
EP2838917A1 (en) 2015-02-25
SG10201913634VA (en) 2020-03-30
JP2015514417A (ja) 2015-05-21
CN114163530B (zh) 2025-04-29
EP2838917B1 (en) 2019-06-05
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CN120383672A (zh) 2025-07-29
US11926859B2 (en) 2024-03-12

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