DK3312156T3 - Fremgangsmåder til fremstilling af (s)-1-(3-ethoxy-4-methoxyphenyl)-2-methansulfonylethylamin - Google Patents
Fremgangsmåder til fremstilling af (s)-1-(3-ethoxy-4-methoxyphenyl)-2-methansulfonylethylamin Download PDFInfo
- Publication number
- DK3312156T3 DK3312156T3 DK17197504.8T DK17197504T DK3312156T3 DK 3312156 T3 DK3312156 T3 DK 3312156T3 DK 17197504 T DK17197504 T DK 17197504T DK 3312156 T3 DK3312156 T3 DK 3312156T3
- Authority
- DK
- Denmark
- Prior art keywords
- methansulphonylethylamine
- methoxyphenyl
- ethoxy
- preparing
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/06—Sulfinamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261601226P | 2012-02-21 | 2012-02-21 | |
| EP13706898.7A EP2817288B1 (en) | 2012-02-21 | 2013-02-20 | Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3312156T3 true DK3312156T3 (da) | 2019-07-22 |
Family
ID=47755073
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18168969.6T DK3378850T3 (da) | 2012-02-21 | 2013-02-20 | Fremgangsmåder til fremstilling af (s)-1-(3-ethoxy-4-methoxyphenyl)-2-methansulfonylethylamin |
| DK17197504.8T DK3312156T3 (da) | 2012-02-21 | 2013-02-20 | Fremgangsmåder til fremstilling af (s)-1-(3-ethoxy-4-methoxyphenyl)-2-methansulfonylethylamin |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18168969.6T DK3378850T3 (da) | 2012-02-21 | 2013-02-20 | Fremgangsmåder til fremstilling af (s)-1-(3-ethoxy-4-methoxyphenyl)-2-methansulfonylethylamin |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US9187417B2 (da) |
| EP (4) | EP3312156B1 (da) |
| JP (1) | JP2015509496A (da) |
| KR (1) | KR101993248B1 (da) |
| CN (3) | CN107033042A (da) |
| AR (2) | AR090100A1 (da) |
| AU (1) | AU2013203283B2 (da) |
| BR (3) | BR122021020046B1 (da) |
| CA (1) | CA2864517A1 (da) |
| CO (1) | CO7061071A2 (da) |
| CR (1) | CR20140395A (da) |
| CY (2) | CY1121833T1 (da) |
| DK (2) | DK3378850T3 (da) |
| ES (3) | ES2675168T3 (da) |
| HK (1) | HK1205501A1 (da) |
| HR (2) | HRP20191249T1 (da) |
| HU (2) | HUE044192T2 (da) |
| IL (3) | IL234135A (da) |
| IN (1) | IN2014DN06740A (da) |
| LT (2) | LT3378850T (da) |
| MX (2) | MX350731B (da) |
| MY (1) | MY168296A (da) |
| NI (1) | NI201400093A (da) |
| NZ (1) | NZ628028A (da) |
| PH (1) | PH12014501865B1 (da) |
| PL (2) | PL3378850T3 (da) |
| PT (2) | PT3378850T (da) |
| RS (2) | RS59071B1 (da) |
| RU (1) | RU2632875C2 (da) |
| SG (1) | SG11201405035XA (da) |
| SI (2) | SI3378850T1 (da) |
| TR (1) | TR201910430T4 (da) |
| TW (1) | TW201336815A (da) |
| UA (1) | UA116773C2 (da) |
| WO (1) | WO2013126360A2 (da) |
| ZA (1) | ZA201405892B (da) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9126906B2 (en) * | 2012-02-21 | 2015-09-08 | Celgene Corporation | Asymmetric synthetic processes for the preparation of aminosulfone compounds |
| AR090100A1 (es) | 2012-02-21 | 2014-10-22 | Celgene Corp | Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina |
| WO2014204825A1 (en) | 2013-06-17 | 2014-12-24 | Celgene Corporation | Tablet formulations of (+)-2-[1 -(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| IN2014MU01283A (da) | 2014-04-04 | 2015-10-09 | Cadila Healthcare Ltd | |
| WO2015173792A1 (en) | 2014-05-11 | 2015-11-19 | Mapi Pharma Ltd. | Amorphous form of apremilast |
| EP2949645A1 (en) | 2014-05-28 | 2015-12-02 | LEK Pharmaceuticals d.d. | Processes for the preparation of ß-aminosulfone compounds |
| CN105622380B (zh) * | 2014-10-29 | 2020-06-30 | 南京安源生物医药科技有限公司 | 一种阿普斯特的制备方法及其中间体 |
| CN104447445B (zh) * | 2014-12-05 | 2016-07-06 | 新发药业有限公司 | 一种合成阿普斯特中间体的制备方法 |
| CN104744323B (zh) * | 2015-03-11 | 2016-08-31 | 中山奕安泰医药科技有限公司 | 一种阿普斯特手性胺中间体的合成工艺 |
| CN104761474B (zh) * | 2015-03-11 | 2016-11-30 | 中山奕安泰医药科技有限公司 | 一种阿普斯特手性胺中间体的合成方法 |
| CN104803897A (zh) * | 2015-04-23 | 2015-07-29 | 中山奕安泰医药科技有限公司 | 一种阿普斯特中间体的合成工艺 |
| WO2016174685A1 (en) * | 2015-04-27 | 2016-11-03 | Mylan Laboratories Limited | Process for the enantiomeric resolution of apremilast intermediates |
| EP3307711A1 (en) * | 2015-06-09 | 2018-04-18 | Dr. Reddy's Laboratories Ltd. | Process for preparation of apremilast and its intermediates |
| EP3106457A1 (en) | 2015-06-15 | 2016-12-21 | LEK Pharmaceuticals d.d. | A novel synthetic pathway towards apremilast |
| EP3144393A1 (en) | 2015-09-18 | 2017-03-22 | LEK Pharmaceuticals d.d. | A synthetic pathway towards apremilast |
| EP3356327A1 (en) | 2015-09-29 | 2018-08-08 | Pliva Hrvatska D.O.O. | Processes for the preparation of apremilast and intermediates thereof |
| US10399942B2 (en) | 2015-11-19 | 2019-09-03 | Alembic Pharmaceuticals Limited | Process and novel polymorphic form of Apremilast |
| CN105461602B (zh) * | 2015-11-27 | 2018-01-02 | 东华大学 | 手性S或R‑3‑乙氧基‑4‑甲氧基‑α‑[(甲磺酰基)甲基]苯甲醇的制备方法 |
| CN105330586B (zh) * | 2015-11-27 | 2017-12-22 | 东华大学 | 一种阿普斯特的制备方法 |
| WO2017094031A2 (en) * | 2015-12-04 | 2017-06-08 | Sun Pharmaceutical Industries Limited | Novel process for preparation of apremilast |
| CN106866475B (zh) * | 2015-12-11 | 2018-03-30 | 北大方正集团有限公司 | 一种阿普斯特中间体及其制备方法 |
| US10774041B2 (en) | 2016-04-15 | 2020-09-15 | Davuluri Ramamohan Rao | Process for the preparation of apremilast |
| US10196355B2 (en) | 2016-06-20 | 2019-02-05 | Johnson Matthey Public Limited Company | Forms of apremilast |
| CN106543050B (zh) * | 2016-09-28 | 2018-04-10 | 中南大学湘雅医院 | 一种阿普斯特中间体的合成工艺 |
| WO2018061034A1 (en) * | 2016-09-30 | 2018-04-05 | Sun Pharmaceutical Industries Limited | Novel process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine |
| US11000888B2 (en) | 2016-11-10 | 2021-05-11 | Sms Group Gmbh | Method for producing a metal strip in a cast-rolling installation |
| CN107445875A (zh) * | 2017-03-22 | 2017-12-08 | 陕西科技大学 | 一种用于制备阿普斯特的高纯度中间体的手性拆分方法 |
| HUE054270T2 (hu) | 2017-04-04 | 2021-08-30 | Quim Sintetica S A | Racém béta-aminoszulfon vegyületek |
| HUE051684T2 (hu) | 2017-04-04 | 2021-03-29 | Quim Sintetica S A | Racém béta-aminoszulfon vegyületek rezolválása |
| CN107827722B (zh) * | 2017-11-23 | 2021-02-19 | 中山奕安泰医药科技有限公司 | 一种3-乙氧基-4-甲氧基苯甲醛的合成方法 |
| CN107966509B (zh) * | 2017-11-23 | 2020-06-23 | 中山奕安泰医药科技有限公司 | 一种(s)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺的检测方法 |
| CN107976501B (zh) * | 2017-11-23 | 2020-08-25 | 中山奕安泰医药科技有限公司 | 一种1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺的检测方法 |
| CN107941945B (zh) * | 2017-11-23 | 2020-12-22 | 中山奕安泰医药科技有限公司 | 一种3-乙氧基-4-甲氧基苯甲腈的检测方法 |
| CN108008035B (zh) * | 2017-11-23 | 2020-07-07 | 中山奕安泰医药科技有限公司 | 3-乙氧基-4-甲氧基苯甲醛纯度的检测方法 |
| CN108084066A (zh) * | 2017-12-12 | 2018-05-29 | 中山大学 | 一种阿普斯特及对映异构体的合成方法 |
| JP6673614B1 (ja) * | 2018-10-16 | 2020-03-25 | 東芝エレベータ株式会社 | 防音装置 |
| CN113896674B (zh) * | 2021-09-01 | 2023-10-27 | 深圳华中科技大学研究院 | 一种阿普斯特的合成方法 |
| CN115850129B (zh) * | 2023-02-28 | 2023-05-16 | 凯莱英生命科学技术(天津)有限公司 | （s）-1-(3-乙氧基-4-甲氧基苯基)-2-（甲磺酰基）乙胺的制备方法 |
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| US3878252A (en) * | 1970-09-24 | 1975-04-15 | Burroughs Wellcome Co | Ring substituted beta-hydroxy-phenyethylmethyl sulphone or sulphoxide |
| GB1261455A (en) * | 1969-03-06 | 1972-01-26 | Burroughs Wellcome Co | Improvements in or relating to substituted acrylonitriles |
| DE2051871A1 (en) * | 1969-05-16 | 1971-11-18 | The Wellcome Foundation Ltd., London | Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents |
| NZ331875A (en) | 1996-03-22 | 2000-01-28 | Du Pont Pharm Co | Asymmetric synthesis of R-alpha-propyl-piperonyl amine and its analogs |
| US6020358A (en) | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| ZA200505308B (en) | 2002-12-30 | 2006-10-25 | Celgene Corp | Fluoroalkoxy-substituted 1, 3-Dihydro-Isoindolyl compounds and their pharmaceutical uses |
| US7208526B2 (en) | 2005-05-20 | 2007-04-24 | Hoffmann-La Roche Inc. | Styrylsulfonamides |
| WO2009094528A1 (en) * | 2008-01-25 | 2009-07-30 | High Point Pharmaceuticals, Llc | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS |
| MY155424A (en) * | 2008-09-10 | 2015-10-15 | Celgene Corp | Processes for the preparation of aminosulfone compounds |
| US8124646B2 (en) | 2009-06-18 | 2012-02-28 | Concert Pharmaceuticals, Inc. | Substituted isoindoline-1,3-dione derivatives |
| AR078581A1 (es) | 2009-10-09 | 2011-11-16 | Celgene Corp | Procesos para la preparacion de compuestos 2-(1-feniletil)isoindolin-1-ona |
| US9045417B2 (en) | 2011-01-14 | 2015-06-02 | Celgene Corporation | Isotopologues of isoindole derivatives |
| US9126906B2 (en) * | 2012-02-21 | 2015-09-08 | Celgene Corporation | Asymmetric synthetic processes for the preparation of aminosulfone compounds |
| AR090100A1 (es) * | 2012-02-21 | 2014-10-22 | Celgene Corp | Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina |
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2013
- 2013-02-19 AR ARP130100512A patent/AR090100A1/es active IP Right Grant
- 2013-02-20 LT LTEP18168969.6T patent/LT3378850T/lt unknown
- 2013-02-20 BR BR122021020046-7A patent/BR122021020046B1/pt active IP Right Grant
- 2013-02-20 ES ES13706898.7T patent/ES2675168T3/es active Active
- 2013-02-20 MY MYPI2014702288A patent/MY168296A/en unknown
- 2013-02-20 SI SI201331685T patent/SI3378850T1/sl unknown
- 2013-02-20 CN CN201710255841.0A patent/CN107033042A/zh active Pending
- 2013-02-20 CN CN202110092737.0A patent/CN112812044B/zh active Active
- 2013-02-20 MX MX2016016157A patent/MX350731B/es unknown
- 2013-02-20 EP EP17197504.8A patent/EP3312156B1/en active Active
- 2013-02-20 TW TW102105901A patent/TW201336815A/zh unknown
- 2013-02-20 EP EP18168969.6A patent/EP3378850B8/en active Active
- 2013-02-20 IN IN6740DEN2014 patent/IN2014DN06740A/en unknown
- 2013-02-20 US US13/771,164 patent/US9187417B2/en active Active
- 2013-02-20 UA UAA201410289A patent/UA116773C2/uk unknown
- 2013-02-20 WO PCT/US2013/026780 patent/WO2013126360A2/en active Application Filing
- 2013-02-20 MX MX2014010002A patent/MX344190B/es active IP Right Grant
- 2013-02-20 BR BR112014020444-6A patent/BR112014020444B1/pt active IP Right Grant
- 2013-02-20 PL PL18168969T patent/PL3378850T3/pl unknown
- 2013-02-20 DK DK18168969.6T patent/DK3378850T3/da active
- 2013-02-20 PL PL17197504T patent/PL3312156T3/pl unknown
- 2013-02-20 PT PT181689696T patent/PT3378850T/pt unknown
- 2013-02-20 SG SG11201405035XA patent/SG11201405035XA/en unknown
- 2013-02-20 KR KR1020147026186A patent/KR101993248B1/ko active IP Right Grant
- 2013-02-20 EP EP13706898.7A patent/EP2817288B1/en active Active
- 2013-02-20 CA CA2864517A patent/CA2864517A1/en not_active Withdrawn
- 2013-02-20 TR TR2019/10430T patent/TR201910430T4/tr unknown
- 2013-02-20 PT PT17197504T patent/PT3312156T/pt unknown
- 2013-02-20 BR BR122021020040-8A patent/BR122021020040B1/pt active IP Right Grant
- 2013-02-20 RS RS20190895A patent/RS59071B1/sr unknown
- 2013-02-20 ES ES17197504T patent/ES2735801T3/es active Active
- 2013-02-20 EP EP20150560.9A patent/EP3702347B1/en active Active
- 2013-02-20 DK DK17197504.8T patent/DK3312156T3/da active
- 2013-02-20 HU HUE17197504 patent/HUE044192T2/hu unknown
- 2013-02-20 RS RS20200185A patent/RS60036B1/sr unknown
- 2013-02-20 SI SI201331526T patent/SI3312156T1/sl unknown
- 2013-02-20 CN CN201380020005.4A patent/CN104245668B/zh active Active
- 2013-02-20 HU HUE18168969A patent/HUE048412T2/hu unknown
- 2013-02-20 JP JP2014558783A patent/JP2015509496A/ja active Pending
- 2013-02-20 AU AU2013203283A patent/AU2013203283B2/en active Active
- 2013-02-20 RU RU2014138037A patent/RU2632875C2/ru active
- 2013-02-20 NZ NZ628028A patent/NZ628028A/en unknown
- 2013-02-20 LT LTEP17197504.8T patent/LT3312156T/lt unknown
- 2013-02-20 ES ES18168969T patent/ES2773686T3/es active Active
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2014
- 2014-08-12 ZA ZA2014/05892A patent/ZA201405892B/en unknown
- 2014-08-14 IL IL234135A patent/IL234135A/en active IP Right Grant
- 2014-08-18 PH PH12014501865A patent/PH12014501865B1/en unknown
- 2014-08-20 NI NI201400093A patent/NI201400093A/es unknown
- 2014-08-21 CR CR20140395A patent/CR20140395A/es unknown
- 2014-08-21 CO CO14183628A patent/CO7061071A2/es unknown
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2015
- 2015-06-25 HK HK15106059.8A patent/HK1205501A1/xx unknown
- 2015-10-14 US US14/882,564 patent/US9586897B2/en active Active
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2017
- 2017-01-25 US US15/414,782 patent/US9688623B2/en active Active
- 2017-05-23 IL IL252459A patent/IL252459B/en active IP Right Grant
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2019
- 2019-07-11 CY CY20191100742T patent/CY1121833T1/el unknown
- 2019-07-12 HR HRP20191249TT patent/HRP20191249T1/hr unknown
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2020
- 2020-01-10 AR ARP200100066A patent/AR117963A2/es unknown
- 2020-02-13 HR HRP20200245TT patent/HRP20200245T1/hr unknown
- 2020-02-21 CY CY20201100163T patent/CY1122799T1/el unknown
- 2020-03-04 IL IL273050A patent/IL273050A/en active IP Right Grant
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