PL3378850T3 - Sposoby wytwarzania (s)-1-(3-etoksy-4-metoksyfenylo)-2-metanosulfonyloetyloaminy - Google Patents
Sposoby wytwarzania (s)-1-(3-etoksy-4-metoksyfenylo)-2-metanosulfonyloetyloaminyInfo
- Publication number
- PL3378850T3 PL3378850T3 PL18168969T PL18168969T PL3378850T3 PL 3378850 T3 PL3378850 T3 PL 3378850T3 PL 18168969 T PL18168969 T PL 18168969T PL 18168969 T PL18168969 T PL 18168969T PL 3378850 T3 PL3378850 T3 PL 3378850T3
- Authority
- PL
- Poland
- Prior art keywords
- methanesulfonylethylamine
- ethoxy
- processes
- preparation
- Prior art date
Links
- BXUJVINGXQGNFD-SNVBAGLBSA-N (1s)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethanamine Chemical compound CCOC1=CC([C@H](N)CS(C)(=O)=O)=CC=C1OC BXUJVINGXQGNFD-SNVBAGLBSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/06—Sulfinamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261601226P | 2012-02-21 | 2012-02-21 | |
| EP13706898.7A EP2817288B1 (en) | 2012-02-21 | 2013-02-20 | Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine |
| PCT/US2013/026780 WO2013126360A2 (en) | 2012-02-21 | 2013-02-20 | Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine |
| EP18168969.6A EP3378850B8 (en) | 2012-02-21 | 2013-02-20 | Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3378850T3 true PL3378850T3 (pl) | 2020-07-27 |
Family
ID=47755073
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17197504T PL3312156T3 (pl) | 2012-02-21 | 2013-02-20 | Procesy dla przygotowywania (s)-1-(3-etoksy-4-metoksyfenylo)-2-metanosulfonyloetyloaminy |
| PL18168969T PL3378850T3 (pl) | 2012-02-21 | 2013-02-20 | Sposoby wytwarzania (s)-1-(3-etoksy-4-metoksyfenylo)-2-metanosulfonyloetyloaminy |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17197504T PL3312156T3 (pl) | 2012-02-21 | 2013-02-20 | Procesy dla przygotowywania (s)-1-(3-etoksy-4-metoksyfenylo)-2-metanosulfonyloetyloaminy |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US9187417B2 (pl) |
| EP (4) | EP3378850B8 (pl) |
| JP (1) | JP2015509496A (pl) |
| KR (1) | KR101993248B1 (pl) |
| CN (3) | CN107033042A (pl) |
| AR (2) | AR090100A1 (pl) |
| AU (1) | AU2013203283B2 (pl) |
| BR (3) | BR112014020444B1 (pl) |
| CA (1) | CA2864517A1 (pl) |
| CO (1) | CO7061071A2 (pl) |
| CR (1) | CR20140395A (pl) |
| CY (2) | CY1121833T1 (pl) |
| DK (2) | DK3312156T3 (pl) |
| ES (4) | ES2675168T3 (pl) |
| HR (2) | HRP20191249T1 (pl) |
| HU (2) | HUE048412T2 (pl) |
| IL (3) | IL234135A (pl) |
| IN (1) | IN2014DN06740A (pl) |
| LT (2) | LT3312156T (pl) |
| MX (2) | MX344190B (pl) |
| MY (1) | MY168296A (pl) |
| NI (1) | NI201400093A (pl) |
| NZ (1) | NZ628028A (pl) |
| PH (1) | PH12014501865B1 (pl) |
| PL (2) | PL3312156T3 (pl) |
| PT (2) | PT3312156T (pl) |
| RS (2) | RS60036B1 (pl) |
| RU (1) | RU2632875C2 (pl) |
| SG (1) | SG11201405035XA (pl) |
| SI (2) | SI3378850T1 (pl) |
| SM (2) | SMT201900397T1 (pl) |
| TR (1) | TR201910430T4 (pl) |
| TW (1) | TW201336815A (pl) |
| UA (1) | UA116773C2 (pl) |
| WO (1) | WO2013126360A2 (pl) |
| ZA (1) | ZA201405892B (pl) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR090100A1 (es) * | 2012-02-21 | 2014-10-22 | Celgene Corp | Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina |
| US9126906B2 (en) * | 2012-02-21 | 2015-09-08 | Celgene Corporation | Asymmetric synthetic processes for the preparation of aminosulfone compounds |
| EP3010490A1 (en) | 2013-06-17 | 2016-04-27 | Celgene Corporation | Tablet formulations of (+)-2-[1 -(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| IN2014MU01283A (pl) | 2014-04-04 | 2015-10-09 | Cadila Healthcare Ltd | |
| EP3143004B1 (en) | 2014-05-11 | 2020-09-02 | Mapi Pharma Limited | Amorphous form of apremilast |
| EP2949645A1 (en) | 2014-05-28 | 2015-12-02 | LEK Pharmaceuticals d.d. | Processes for the preparation of ß-aminosulfone compounds |
| CN105622380B (zh) * | 2014-10-29 | 2020-06-30 | 南京安源生物医药科技有限公司 | 一种阿普斯特的制备方法及其中间体 |
| CN104447445B (zh) * | 2014-12-05 | 2016-07-06 | 新发药业有限公司 | 一种合成阿普斯特中间体的制备方法 |
| CN104744323B (zh) * | 2015-03-11 | 2016-08-31 | 中山奕安泰医药科技有限公司 | 一种阿普斯特手性胺中间体的合成工艺 |
| CN104761474B (zh) * | 2015-03-11 | 2016-11-30 | 中山奕安泰医药科技有限公司 | 一种阿普斯特手性胺中间体的合成方法 |
| CN104803897A (zh) * | 2015-04-23 | 2015-07-29 | 中山奕安泰医药科技有限公司 | 一种阿普斯特中间体的合成工艺 |
| WO2016174685A1 (en) * | 2015-04-27 | 2016-11-03 | Mylan Laboratories Limited | Process for the enantiomeric resolution of apremilast intermediates |
| EP3307711A1 (en) * | 2015-06-09 | 2018-04-18 | Dr. Reddy's Laboratories Ltd. | Process for preparation of apremilast and its intermediates |
| EP3106457A1 (en) | 2015-06-15 | 2016-12-21 | LEK Pharmaceuticals d.d. | A novel synthetic pathway towards apremilast |
| EP3144393A1 (en) * | 2015-09-18 | 2017-03-22 | LEK Pharmaceuticals d.d. | A synthetic pathway towards apremilast |
| EP3356327A1 (en) | 2015-09-29 | 2018-08-08 | Pliva Hrvatska D.O.O. | Processes for the preparation of apremilast and intermediates thereof |
| WO2017085568A1 (en) * | 2015-11-19 | 2017-05-26 | Alembic Pharmaceuticals Limited | An improved process and novel polymorphic form of apremilast |
| CN105330586B (zh) * | 2015-11-27 | 2017-12-22 | 东华大学 | 一种阿普斯特的制备方法 |
| CN105461602B (zh) * | 2015-11-27 | 2018-01-02 | 东华大学 | 手性S或R‑3‑乙氧基‑4‑甲氧基‑α‑[(甲磺酰基)甲基]苯甲醇的制备方法 |
| WO2017094031A2 (en) * | 2015-12-04 | 2017-06-08 | Sun Pharmaceutical Industries Limited | Novel process for preparation of apremilast |
| CN106866475B (zh) * | 2015-12-11 | 2018-03-30 | 北大方正集团有限公司 | 一种阿普斯特中间体及其制备方法 |
| US10774041B2 (en) | 2016-04-15 | 2020-09-15 | Davuluri Ramamohan Rao | Process for the preparation of apremilast |
| US10196355B2 (en) | 2016-06-20 | 2019-02-05 | Johnson Matthey Public Limited Company | Forms of apremilast |
| CN106543050B (zh) * | 2016-09-28 | 2018-04-10 | 中南大学湘雅医院 | 一种阿普斯特中间体的合成工艺 |
| WO2018061034A1 (en) * | 2016-09-30 | 2018-04-05 | Sun Pharmaceutical Industries Limited | Novel process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine |
| JP6684968B2 (ja) | 2016-11-10 | 2020-04-22 | エス・エム・エス・グループ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 連続鋳造圧延設備内において、金属的なストリップを製造するための方法 |
| CN107445875A (zh) * | 2017-03-22 | 2017-12-08 | 陕西科技大学 | 一种用于制备阿普斯特的高纯度中间体的手性拆分方法 |
| PT3606907T (pt) | 2017-04-04 | 2021-04-01 | Quim Sintetica S A | Compostos de beta-aminossulfona racémica |
| US11149003B2 (en) | 2017-04-04 | 2021-10-19 | Quimica Sintetica, S.A. | Resolution of racemic beta-aminosulfone compounds |
| CN107966509B (zh) * | 2017-11-23 | 2020-06-23 | 中山奕安泰医药科技有限公司 | 一种(s)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺的检测方法 |
| CN107976501B (zh) * | 2017-11-23 | 2020-08-25 | 中山奕安泰医药科技有限公司 | 一种1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺的检测方法 |
| CN108008035B (zh) * | 2017-11-23 | 2020-07-07 | 中山奕安泰医药科技有限公司 | 3-乙氧基-4-甲氧基苯甲醛纯度的检测方法 |
| CN107827722B (zh) * | 2017-11-23 | 2021-02-19 | 中山奕安泰医药科技有限公司 | 一种3-乙氧基-4-甲氧基苯甲醛的合成方法 |
| CN107941945B (zh) * | 2017-11-23 | 2020-12-22 | 中山奕安泰医药科技有限公司 | 一种3-乙氧基-4-甲氧基苯甲腈的检测方法 |
| CN108084066A (zh) * | 2017-12-12 | 2018-05-29 | 中山大学 | 一种阿普斯特及对映异构体的合成方法 |
| JP6673614B1 (ja) * | 2018-10-16 | 2020-03-25 | 東芝エレベータ株式会社 | 防音装置 |
| CN113896674B (zh) * | 2021-09-01 | 2023-10-27 | 深圳华中科技大学研究院 | 一种阿普斯特的合成方法 |
| JP2024545712A (ja) | 2021-12-21 | 2024-12-10 | ガンチョウ ヘメイ ファーマシューティカル カンパニー リミテッド | チオフェン誘導体の調製 |
| CN115850129B (zh) * | 2023-02-28 | 2023-05-16 | 凯莱英生命科学技术(天津)有限公司 | （s）-1-(3-乙氧基-4-甲氧基苯基)-2-（甲磺酰基）乙胺的制备方法 |
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|---|---|---|---|---|
| GB1261455A (en) * | 1969-03-06 | 1972-01-26 | Burroughs Wellcome Co | Improvements in or relating to substituted acrylonitriles |
| US3878252A (en) * | 1970-09-24 | 1975-04-15 | Burroughs Wellcome Co | Ring substituted beta-hydroxy-phenyethylmethyl sulphone or sulphoxide |
| DE2051871A1 (en) | 1969-05-16 | 1971-11-18 | The Wellcome Foundation Ltd., London | Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents |
| NZ331875A (en) | 1996-03-22 | 2000-01-28 | Du Pont Pharm Co | Asymmetric synthesis of R-alpha-propyl-piperonyl amine and its analogs |
| US6020358A (en) * | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| JP5269281B2 (ja) | 2002-12-30 | 2013-08-21 | セルジーン コーポレイション | フルオロアルコキシ置換１，３−ジヒドロイソインドリル化合物およびそれらの医薬としての使用 |
| US7208526B2 (en) | 2005-05-20 | 2007-04-24 | Hoffmann-La Roche Inc. | Styrylsulfonamides |
| KR101709141B1 (ko) * | 2008-01-25 | 2017-02-22 | 브이티브이 테라퓨틱스 엘엘씨 | ＴＮＦ-α 합성의 조절자 및 ＰＤＥ4 억제제로서 3고리 화합물 |
| CA2736171A1 (en) * | 2008-09-10 | 2010-03-18 | Celgene Corporation | Processes for the preparation of aminosulfone compounds |
| EA021019B1 (ru) * | 2009-06-18 | 2015-03-31 | Концерт Фармасьютикалс, Инк. | Дейтерированные производные изоиндолин-1,3-диона |
| NZ599147A (en) | 2009-10-09 | 2014-03-28 | Celgene Corp | Processes for the preparation of 2-(1-phenylethyl) isoindolin-1-one compounds |
| WO2012097116A2 (en) | 2011-01-14 | 2012-07-19 | Celgene Corporation | Isotopologues of isoindole derivatives |
| AR090100A1 (es) * | 2012-02-21 | 2014-10-22 | Celgene Corp | Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina |
| US9126906B2 (en) * | 2012-02-21 | 2015-09-08 | Celgene Corporation | Asymmetric synthetic processes for the preparation of aminosulfone compounds |
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2013
- 2013-02-19 AR ARP130100512A patent/AR090100A1/es active IP Right Grant
- 2013-02-20 ES ES13706898.7T patent/ES2675168T3/es active Active
- 2013-02-20 PL PL17197504T patent/PL3312156T3/pl unknown
- 2013-02-20 ES ES17197504T patent/ES2735801T3/es active Active
- 2013-02-20 HU HUE18168969A patent/HUE048412T2/hu unknown
- 2013-02-20 EP EP18168969.6A patent/EP3378850B8/en active Active
- 2013-02-20 PT PT17197504T patent/PT3312156T/pt unknown
- 2013-02-20 DK DK17197504.8T patent/DK3312156T3/da active
- 2013-02-20 CN CN201710255841.0A patent/CN107033042A/zh active Pending
- 2013-02-20 RU RU2014138037A patent/RU2632875C2/ru active
- 2013-02-20 SM SM20190397T patent/SMT201900397T1/it unknown
- 2013-02-20 ES ES18168969T patent/ES2773686T3/es active Active
- 2013-02-20 PL PL18168969T patent/PL3378850T3/pl unknown
- 2013-02-20 LT LTEP17197504.8T patent/LT3312156T/lt unknown
- 2013-02-20 SM SM20200107T patent/SMT202000107T1/it unknown
- 2013-02-20 TW TW102105901A patent/TW201336815A/zh unknown
- 2013-02-20 JP JP2014558783A patent/JP2015509496A/ja active Pending
- 2013-02-20 SG SG11201405035XA patent/SG11201405035XA/en unknown
- 2013-02-20 EP EP20150560.9A patent/EP3702347B1/en active Active
- 2013-02-20 MX MX2014010002A patent/MX344190B/es active IP Right Grant
- 2013-02-20 AU AU2013203283A patent/AU2013203283B2/en active Active
- 2013-02-20 SI SI201331685T patent/SI3378850T1/sl unknown
- 2013-02-20 MY MYPI2014702288A patent/MY168296A/en unknown
- 2013-02-20 HU HUE17197504 patent/HUE044192T2/hu unknown
- 2013-02-20 CN CN201380020005.4A patent/CN104245668B/zh active Active
- 2013-02-20 RS RS20200185A patent/RS60036B1/sr unknown
- 2013-02-20 EP EP13706898.7A patent/EP2817288B1/en active Active
- 2013-02-20 MX MX2016016157A patent/MX350731B/es unknown
- 2013-02-20 DK DK18168969.6T patent/DK3378850T3/da active
- 2013-02-20 BR BR112014020444-6A patent/BR112014020444B1/pt active IP Right Grant
- 2013-02-20 CA CA2864517A patent/CA2864517A1/en not_active Withdrawn
- 2013-02-20 CN CN202110092737.0A patent/CN112812044B/zh active Active
- 2013-02-20 NZ NZ628028A patent/NZ628028A/en unknown
- 2013-02-20 WO PCT/US2013/026780 patent/WO2013126360A2/en not_active Ceased
- 2013-02-20 LT LTEP18168969.6T patent/LT3378850T/lt unknown
- 2013-02-20 TR TR2019/10430T patent/TR201910430T4/tr unknown
- 2013-02-20 UA UAA201410289A patent/UA116773C2/uk unknown
- 2013-02-20 SI SI201331526T patent/SI3312156T1/sl unknown
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